CN104547933B - A kind of Chinese medicine composition and preparation method and purposes - Google Patents
A kind of Chinese medicine composition and preparation method and purposes Download PDFInfo
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- CN104547933B CN104547933B CN201510014162.5A CN201510014162A CN104547933B CN 104547933 B CN104547933 B CN 104547933B CN 201510014162 A CN201510014162 A CN 201510014162A CN 104547933 B CN104547933 B CN 104547933B
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Abstract
The invention discloses a kind of Chinese medicine composition and its preparation method and application, the Chinese medicine composition is mainly made of raw material of the part by weight by 200~600 parts of 307 317 parts of radix astragali, 620 630 parts of Rhizoma Corydalis (processed with vinegar), 307 317 parts of Angelica sinensis, 370 380 parts of the radix paeoniae rubrathe, 307 317 parts of Radix Salviae Miltiorrhizae, 307 317 parts of Ligusticum wallichii, 307 317 parts of curcuma zedoary, 245 255 parts of bush, 307 317 parts of reticulate millettia and pharmaceutically acceptable carrier.The Chinese medicine composition, which is used in, to be prepared in treatment varix of lower limb medicine, has good therapeutic effect to varix of lower limb.
Description
Technical field
The invention belongs to technical field of medicine, in particular it relates to a kind of Chinese medicine composition and its preparation side
Method and application.
Background technology
Varix of lower limb is more since superficial vein first is to valve (stock saphena valve) superficial vein caused by incompetence
Blood flow reflux, increases disease caused by veins of lower extremity pressure.Weak geneogenous wall of vein is also major reason, and patient often merges
There is the wall of vein defect of the whole body or limitation, in the case of vein pressure is increased, just produce tortuous, the expansion of vein.For a long time
Standing, fat and abdominal pressure etc. can increase the possibility of varication development generation because procatarxis can increase vein pressure.Morbidity
In early days, it is mostly the swollen uncomfortable and dull pain sense of lower limb acid, while has limbs sense of heaviness, it is easily weak.Above-mentioned sensation aggravates behind long station more,
By lying down, limb lifting can then be alleviated.Lesion middle and later periods, wall of vein are damaged, vein protuberance, expansion, it is tortuous, in earthworm sample outside
See, it is obvious with medial leg great saphenous vein traveling area.Course of disease elder, then there is nutrition and sexually revises in limb skin, such as furfur, scabies
Itch, pigmentation etc., or even form eczema and ulcer.With the differentiation of the state of an illness, can swell with the pain of blood vessel traveling, lower limb
The symptoms such as swollen, stasis dermatitis, superficial vein thrombus.Improvement of the existing medicine to above-mentioned symptom is out of condition.
The content of the invention
The object of the present invention is to provide a kind of Chinese medicine composition, and the Chinese medicine composition is to varix of lower limb therapeutic effect
It is good.
To reach above-mentioned purpose, the technical solution adopted by the present invention is as follows：
A kind of Chinese medicine composition, the Chinese medicine composition is mainly 307-317 parts of radix astragali by part by weight, Rhizoma Corydalis (processed with vinegar)
620-630 parts, 307-317 parts of Angelica sinensis, 370-380 parts of the radix paeoniae rubrathe, 307-317 parts of Radix Salviae Miltiorrhizae, 307-317 parts of Ligusticum wallichii, curcuma zedoary 307-317
Part, 245-255 parts of bush, the raw material of 200~600 parts of 307-317 parts of reticulate millettia and pharmaceutically acceptable carrier are made.
Preferably, the Chinese medicine composition is mainly 312 parts of radix astragali, 625 parts of Rhizoma Corydalis (processed with vinegar), Angelica sinensis by part by weight
312 parts, 375 parts of the radix paeoniae rubrathe, 312 parts of Radix Salviae Miltiorrhizae, 312 parts of Ligusticum wallichii, 312 parts of curcuma zedoary, 250 parts of bush, 312 parts of reticulate millettia and pharmaceutically may be used
The raw material for receiving 200~600 parts of carrier is made.
It is a further object of the invention to provide above-mentioned Chinese medicine composition to prepare treatment varix of lower limb medicine
In application.
In above-mentioned technical proposal, the vinegar Hu Yansuo refer to according to《Chinese Pharmacopoeia one》(version in 2010) page 130
And prepared by annex contents of page 20,21.
As the improvement to the Chinese medicine composition described in above-mentioned technical proposal, wherein the pharmaceutically acceptable carrier
Can be one or more of combinations of the derivative of dextrin, starch, cellulose, starch or cellulose etc..
It is still another object of the present invention to provide the preparation side of the Chinese medicine composition described in above-mentioned technical proposal
Method, the described method comprises the following steps：
1) each bulk pharmaceutical chemicals of the parts by weight are weighed；
2) when Rhizoma Corydalis (processed with vinegar) adds the 70% alcohol heat reflux extraction 3 of 6 times of amounts small, recycle ethanol and be concentrated under reduced pressure into 60
DEG C relative density is 1.15~1.20 thick paste；
3) Radix Salviae Miltiorrhizae is taken to add 6 times of amounts of ethanol, when circumfluence distillation 2 is small, filtration, recycles ethanol, be concentrated under reduced pressure into 60 DEG C of phases
To the thick paste that density is 1.15~1.20,8 times of amounts of dregs of a decoction water, when circumfluence distillation 2 is small, filtration, is concentrated under reduced pressure into 60 DEG C of phases
To the thick paste that density is 1.15~1.20；
4) radix astragali, Angelica sinensis, the radix paeoniae rubrathe, Ligusticum wallichii, curcuma zedoary, bush and reticulate millettia are mixed, adds 8 times of calorimetric refluxing extractions 3 of water small
When, filtration, is concentrated under reduced pressure into the thick paste that 60 DEG C of relative densities are 1.15~1.20；
5) using pharmaceutically acceptable carrier as base-material, put in Fluidbedgranulatingdrier；By step 2) -4) prepare thick paste
Mixing, sprays into Fluidbedgranulatingdrier, drying of pelletizing, to obtain the final product.
The preparation method of Chinese medicine preparation described in above-mentioned technical proposal, wherein the pharmaceutically acceptable carrier can be with
One or more of combinations of derivative for dextrin, starch, cellulose, starch or cellulose etc..
The Chinese medicine composition and its preparation of the present invention can effectively treat varix of lower limb.
Embodiment
To readily appreciate technical scheme, the present invention is made further below in conjunction with embodiment
It is bright.
Embodiment 1：
Radix astragali 307g, Rhizoma Corydalis (processed with vinegar) 620g, Angelica sinensis 307g, radix paeoniae rubrathe 370g, Radix Salviae Miltiorrhizae 307g, Ligusticum wallichii 307g, curcuma zedoary 307g,
Bush 245g, reticulate millettia 307g.Nine taste of the above, when Rhizoma Corydalis (processed with vinegar) adds the 70% alcohol heat reflux extraction 3 of 6 times of amounts small, recycling
Ethanol is simultaneously concentrated under reduced pressure into the thick paste that 60 DEG C of relative densities are 1.15~1.20；Radix Salviae Miltiorrhizae is taken to add 6 times of amounts of ethanol, circumfluence distillation
2 it is small when, filtration, recycles ethanol, is concentrated under reduced pressure into the thick paste that 60 DEG C of relative densities are 1.15~1.20, and the dregs of a decoction add 8 times of water amount,
When circumfluence distillation 2 is small, filtration, is concentrated under reduced pressure into the thick paste that 60 DEG C of relative densities are 1.15~1.20；By radix astragali, Angelica sinensis,
The radix paeoniae rubrathe, Ligusticum wallichii, curcuma zedoary, bush and reticulate millettia mixing, when adding 8 times of calorimetric refluxing extractions 3 of water small, filtration, is concentrated under reduced pressure into 60
DEG C relative density is 1.15~1.20 thick paste；Using the dextrin of 200g as base-material, put in Fluidbedgranulatingdrier；By above-mentioned system
Standby thick paste mixing, sprays into Fluidbedgranulatingdrier, drying of pelletizing.142 parts will be divided into after dried particle whole grain, point
Bag is not packaged into, and each bag is a dosage.
Embodiment 2：
Radix astragali 317g, Rhizoma Corydalis (processed with vinegar) 630g, Angelica sinensis 317g, radix paeoniae rubrathe 380g, Radix Salviae Miltiorrhizae 317g, Ligusticum wallichii 317g, curcuma zedoary 317g,
Bush 255g, reticulate millettia 317g.Nine taste of the above, when Rhizoma Corydalis (processed with vinegar) adds the 70% alcohol heat reflux extraction 3 of 6 times of amounts small, recycling
Ethanol is simultaneously concentrated under reduced pressure into the thick paste that 60 DEG C of relative densities are 1.15~1.20；Radix Salviae Miltiorrhizae is taken to add 6 times of amounts of ethanol, circumfluence distillation
2 it is small when, filtration, recycles ethanol, is concentrated under reduced pressure into the thick paste that 60 DEG C of relative densities are 1.15~1.20,8 times of dregs of a decoction water amount, heat
When refluxing extraction 2 is small, filtration, is concentrated under reduced pressure into the thick paste that 60 DEG C of relative densities are 1.15~1.20；By radix astragali, Angelica sinensis, red
Chinese herbaceous peony, Ligusticum wallichii, curcuma zedoary, bush and reticulate millettia mixing, when adding 8 times of calorimetric refluxing extractions 3 of water small, filtration, is concentrated under reduced pressure at 60 DEG C
Relative density is 1.15~1.20 thick paste；The dextrin of 600g is mixed as base-material, is put in Fluidbedgranulatingdrier；Will be above-mentioned
The thick paste mixing of preparation, sprays into Fluidbedgranulatingdrier, drying of pelletizing.142 parts will be divided into after dried particle whole grain,
Bag is packaged into respectively, and each bag is a dosage.
Embodiment 3：
Radix astragali 312g, Rhizoma Corydalis (processed with vinegar) 625g, Angelica sinensis 312g, radix paeoniae rubrathe 375g, Radix Salviae Miltiorrhizae 312g, Ligusticum wallichii 312g, curcuma zedoary 312g,
Bush 250g, reticulate millettia 312g.Nine taste of the above, when Rhizoma Corydalis (processed with vinegar) adds the 70% alcohol heat reflux extraction 3 of 6 times of amounts small, recycling
Ethanol is simultaneously concentrated under reduced pressure into the thick paste that 60 DEG C of relative densities are 1.15~1.20；Radix Salviae Miltiorrhizae is taken to add 6 times of amounts of ethanol, circumfluence distillation
2 it is small when, filtration, recycles ethanol, is concentrated under reduced pressure into the thick paste that 60 DEG C of relative densities are 1.15~1.20,8 times of dregs of a decoction water amount, heat
When refluxing extraction 2 is small, filtration, is concentrated under reduced pressure into the thick paste that 60 DEG C of relative densities are 1.15~1.20；By radix astragali, Angelica sinensis, red
Chinese herbaceous peony, Ligusticum wallichii, safflower, bush and reticulate millettia mixing, when adding 8 times of calorimetric refluxing extractions 3 of water small, filtration, is concentrated under reduced pressure at 60 DEG C
Relative density is 1.15-1.20 thick paste；Using the dextrin of 400g as base-material, put in Fluidbedgranulatingdrier；By above-mentioned preparation
Thick paste mixing, spray into Fluidbedgranulatingdrier, pelletize drying.142 parts will be divided into after dried particle whole grain, respectively
Bag is packaged into, each bag is a dosage.
Come that the present invention is further explained the Chinese medicine preparation be used to prepare that treatment lower limb are quiet below by way of specific test example
Possessed beneficial effect during arteries and veins varicose medicine：
First, method
1. clinical data
According to《Clinic diagnosis guide-surgery fascicle》,《Disease of tcm Standardization of diagnosis and curative effect》The diagnostic criteria of middle ulcer on the shank,
Selection is diagnosed as varix of lower limb, clinical syndrome differentiation is the patient 30 of qi stagnation and blood stasis type, includes this research：
Case selection inclusive criteria：(1), traditional Chinese and western medicine diagnostic criteria is met；(2), deep veins of lower limb ultrasound prompting Deep venou
Valvular function is normal, no thrombus；(3), 40-70 years old.
Exclusion standard：(1), diabetes and other serious disease persons；(2), the person that has lower-limb deep veins thrombus；(3), other after
The varix of lower limb of hair property reason.
Treatment method：All patients give embodiment 1-3 preparation Chinese medicine composition, 1 bag/time, 3 times/day, the course for the treatment of 8 weeks.
Observation index：Observe pretherapy and post-treatment patient main clinic symptoms change (lower extremity swelling and distension is heavy, rope bar, color
It is plain calm).The pretherapy and post-treatment hemorheology change of laboratory examination.Forbid having promoting blood circulationization using other during all patient's treatments
The stasis of blood, the medicine for promoting microcirculation.
2. statistical method
All data carry out variance analysis using SPSS13.0 statistical analysis softwares, are as a result represented with x ± s, with P<
0.05 is statistically significant for difference.
2nd, result
1. pretherapy and post-treatment cardinal symptom changes
30 patients are after treatment, and cardinal symptom swelling is heavy, rope bar, pigmentation have improvement before relatively treating,
There is significant difference.It is shown in Table 1.
1. pretherapy and post-treatment cardinal symptom of table improves situation【Number of cases (%)】
| Project | Number of cases | Disappear | Improve | It is unchanged |
| Swelling is heavy | 30 | 10(33.3) | 18(60.0) | 2(6.7) |
| Rope bar | 30 | 6(20.0) | 22(73.3) | 2(6.7) |
| Pigmentation | 30 | 7(23.3) | 19(63.3) | 4(13.3) |
2nd, pretherapy and post-treatment hemorheology situation of change
After treatment, the hemorheology of patient improves obvious, blood viscosity, packed cell volume, fibrinogen, red blood cell
Sedimentation rate is significantly improved before relatively treating.It is shown in Table 2.
The pretherapy and post-treatment hemorheology in patients situation of change of table 2. (n=30,)
| Project | Before treatment | After treatment |
| Whole blood viscosity height is cut (mpa.s) | 5.52±0.75 | 2.81±0.78** |
| Whole blood viscosity undercut (mpa.s) | 12.53±1.67 | 8.23±1.79* |
| Plasma viscosity (mpa.s) | 2.61±0.39 | 1.45±0.42** |
| Packed cell volume (%) | 48.39±5.56 | 41.96±5.77* |
| Fibrinogen (g/L) | 4.39±1.28 | 3.11±1.25* |
| Erythrocyte sedimentation rate (ESR) (mm/h) | 26.97±10.20 | 17.35±8.16* |
Compared with before treatment, * p ＜ 0.05, * * p ＜ 0.01
3rd, conclusion
Varix of lower limb is because of superficial veins of lower limb valve insufficiency, makes intravenous thrombosis, and the distal vein stasis of blood is stagnant,
Then wall of vein is expanded, and irregular expansion and distortion occurs, caused by causing superficial veins of lower limb extravasated blood.Chinese medicine composition of the present invention
Function qi and activate blood circulation, removing blood stasis for promoting tissue regeneration, remove obstruction in channels to relieve pain, and can promote blood circulation, and it is stagnant to improve the vein stasis of blood.This observation indicate that,
Chinese medicine composition of the present invention has obvious effect to eliminating the cardinal symptoms such as heavy patient's swelling, rope bar, pigmentation, treats
Hemorheological indexes are also significantly improved afterwards, so as to illustrate that Chinese medicine composition of the present invention has very varix of lower limb
The effect of good.
It should be noted last that the above embodiments are merely illustrative of the technical solutions of the present invention and it is unrestricted.Although ginseng
The present invention is described in detail according to embodiment, it will be apparent to an ordinarily skilled person in the art that the technical side to the present invention
Case technical scheme is modified or replaced equivalently, without departure from the spirit and scope of technical solution of the present invention, it should all cover in the present invention
Right among.
Claims (5)
1. a kind of Chinese medicine composition for being used to treat varix of lower limb, it is characterised in that the Chinese medicine composition is by weight ratio
Example is 307-317 parts of radix astragali, 620-630 parts of Rhizoma Corydalis (processed with vinegar), 307-317 parts of Angelica sinensis, 370-380 parts of the radix paeoniae rubrathe, Radix Salviae Miltiorrhizae 307-317
Part, 307-317 parts of Ligusticum wallichii, 307-317 parts of curcuma zedoary, 245-255 parts of bush, 307-317 parts of reticulate millettia and pharmaceutically acceptable load
The raw material that 200~600 parts of body is made.
2. the Chinese medicine composition described in claim 1, it is characterised in that the Chinese medicine composition is radix astragali 312 by part by weight
Part, 625 parts of Rhizoma Corydalis (processed with vinegar), 312 parts of Angelica sinensis, 375 parts of the radix paeoniae rubrathe, 312 parts of Radix Salviae Miltiorrhizae, 312 parts of Ligusticum wallichii, 312 parts of curcuma zedoary, bush 250
The raw material of 200~600 parts of part, 312 parts of reticulate millettia and pharmaceutically acceptable carrier is made.
3. Chinese medicine composition according to claim 1 or 2, it is characterised in that the pharmaceutically acceptable carrier for dextrin,
One or more of combinations in starch, cellulose and its derivates.
4. the preparation method of any Chinese medicine compositions of claim 1-3, the described method comprises the following steps：
1) each bulk pharmaceutical chemicals of the parts by weight are weighed；
2) when Rhizoma Corydalis (processed with vinegar) adds the 70% alcohol heat reflux extraction 3 of 6 times of amounts small, recycle ethanol and be concentrated under reduced pressure into 60 DEG C of phases
To the thick paste that density is 1.15~1.20；
3) Radix Salviae Miltiorrhizae is taken to add 6 times of amounts of ethanol, when circumfluence distillation 2 is small, filtration, recycles ethanol, be concentrated under reduced pressure into relatively close at 60 DEG C
The thick paste for 1.15~1.20 is spent, the dregs of a decoction add 8 times of amounts of water, and when circumfluence distillation 2 is small, filtration, is concentrated under reduced pressure into opposite at 60 DEG C
Density is 1.15~1.20 thick paste；
4) radix astragali, Angelica sinensis, the radix paeoniae rubrathe, Ligusticum wallichii, curcuma zedoary, bush and reticulate millettia are mixed, when adding 8 times of calorimetric refluxing extractions 3 of water small, filter
Cross, be concentrated under reduced pressure into the thick paste that 60 DEG C of relative densities are 1.15~1.20；
5) using pharmaceutically acceptable carrier as base-material, put in Fluidbedgranulatingdrier；By step 2) -4) prepare thick paste mix
Close, spray into Fluidbedgranulatingdrier, drying of pelletizing, to obtain the final product.
5. any Chinese medicine compositions of claim 1-3 are preparing the application in treating varix of lower limb medicine.
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| CN104888104B (en) * | 2015-05-22 | 2018-05-25 | 青岛市胶州中心医院 | One kind is for cirsoid pharmaceutical composition of nursing for treating and preparation method thereof |
| CN105726895A (en) * | 2016-05-10 | 2016-07-06 | 郑植 | Traditional Chinese medicine for treating varicosity |
| CN115770279B (en) * | 2022-11-24 | 2023-11-21 | 上海中医药大学附属曙光医院 | Traditional Chinese medicine composition for treating chronic lower limb vein diseases, decoction and preparation thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2051576A (en) * | 1979-07-05 | 1981-01-21 | Geistlich Soehne Ag Fur Chemis | Compositions for the care of the legs |
| CN103860741A (en) * | 2012-12-13 | 2014-06-18 | 青岛信立德中药技术研究开发有限公司 | Lower limb varicose vein treatment traditional Chinese medicine |
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2015
- 2015-01-12 CN CN201510014162.5A patent/CN104547933B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2051576A (en) * | 1979-07-05 | 1981-01-21 | Geistlich Soehne Ag Fur Chemis | Compositions for the care of the legs |
| CN103860741A (en) * | 2012-12-13 | 2014-06-18 | 青岛信立德中药技术研究开发有限公司 | Lower limb varicose vein treatment traditional Chinese medicine |
Non-Patent Citations (1)
| Title |
|---|
| 中药治疗老年性下肢静脉曲张并发血栓性浅静脉炎12例;郑天贵等;《广西中医药》;20010228;第24卷(第1期);第41页 * |
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