CN104324102A - Traditional Chinese medicine for treating deep venous thrombosis and preparing method thereof - Google Patents
Traditional Chinese medicine for treating deep venous thrombosis and preparing method thereof Download PDFInfo
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- CN104324102A CN104324102A CN201410303528.6A CN201410303528A CN104324102A CN 104324102 A CN104324102 A CN 104324102A CN 201410303528 A CN201410303528 A CN 201410303528A CN 104324102 A CN104324102 A CN 104324102A
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Abstract
The invention relates to a traditional Chinese medicine for treating deep venous thrombosis and a preparing method of the traditional Chinese medicine. The traditional Chinese medicine comprises, by weight, 10 parts of astragalus membranaceus, 6 parts of folium artemisiae argyi, 6 parts of leonurus, 6 parts of lithospermum, 6-10 parts of oriental wormwood, 4 parts of radix angelicae, 8 parts of honeysuckle, 4 parts of roots of common peony, 4 parts of root barks of the peony trees, 4 parts of radix achyranthis bidentatae, 4 parts of roots of red-rooted salvia, 5 parts of cassia twig, 5 parts of angelica sinensis, 7 parts of pseudo-ginseng, 6 parts of cortex acanthopanacis, 4 parts of lycopodium clavatum, 4 parts of rhizoma atractylodis, 4 parts of peach kernels and 3 parts of safflower carthamus. The water extract and alcohol precipitate preparation technologies are adopted in the preparing method; the traditional Chinese medicine has the remarkable curative effect on the deep venous thrombosis. According to the traditional Chinese medicine, the water extract and alcohol precipitate preparation methods are adopted for extracting effective constituents in medicinal materials; on the premise that sufficient dissolution of the effective constituents is guaranteed, extracted impurities are removed to the greatest extent; the taking amount of the medicine is reduced; meanwhile, the possibility for preparing a plurality of dosage forms is increased.
Description
Technical field
The present invention relates to a kind of medicine of venous thrombosis, be specifically related to a kind of Chinese medicine for the treatment of venous thrombosis, the invention still further relates to the preparation method of this Chinese medicine.
Background technology
Venous thrombosis is common peripheral vascular disease, annual morbidity about 1.6 ‰, and in ascendant trend year by year, its, pulmonary infarction complication was the 3rd the common acute cause of death acute stage, and chronic phase causes the sequela such as suffering limb swelling, stasis dermatitis, intractable ulcus cruris to have a strong impact on patients ' life quality because vein valve destroys.Therefore, its study on prevention has become the emphasis in domestic and international peripheral angiopathy field.Tradition western medical treatment means mainly comprise the effective ways such as anticoagulant, thrombolytic, but there is the serious side effects such as irritated, hemorrhage and the shortcoming such as expensive.Chinese medicine has the advantages such as toxic and side effects is little, cheap, therefore becomes the focus of research and development medicine, but relates to multiple link due to its mechanism occurred, and causes lacking action target spot and mechanism square medicine definitely.
Summary of the invention
In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine for the treatment of venous thrombosis and preparation method thereof.
Technical scheme of the present invention is as follows:
Treat a Chinese medicine for venous thrombosis, be prepared from by following weight portion crude drug:
The Radix Astragali 10 parts, Folium Artemisiae Argyi 6 parts, Herba Leonuri 6 parts, Radix Arnebiae (Radix Lithospermi) 6 parts, Herba Artemisiae Scopariae 6 ~ 10 parts, the Radix Angelicae Dahuricae 4 parts, Flos Lonicerae 8 parts, Radix Paeoniae Rubra 4 parts, Cortex Moutan 4 parts, Radix Achyranthis Bidentatae 4 parts, Radix Salviae Miltiorrhizae 4 parts, Ramulus Cinnamomi 5 parts, Radix Angelicae Sinensis 5 parts, Radix Notoginseng 7 parts, Cortex Acanthopancis 6 parts, Herba Lycopodii 4 parts, Rhizoma Atractylodis 4 parts, 4 parts, Semen Persicae, 3 parts, Flos Carthami.
The present invention adopts following preparation method:
Take above medical material by weight, be soaked in the water of 8 times of volumes, fully soak 8 hours, high pressure concentrates boiling machine 120 DEG C and decocts 90 minutes, leaches medicinal liquid; Add 5 times of volume water again, high pressure concentrates boiling machine 120 DEG C and decocts 90 minutes, leaches medicinal liquid; The medicinal liquid leached twice merges, and heating is concentrated, and adding ethanol in concentrated solution to concentration of alcohol is 60%, fully mixes, precipitates overnight, leaching supernatant; Adding ethanol in precipitation to concentration of alcohol is 75%, fully mixes, precipitates overnight, leaching supernatant; Adding ethanol in precipitation to concentration of alcohol is 85%, fully mixes, precipitates overnight, leaching supernatant.Concentrated by the supernatant of three precipitate with ethanol leachings mixing final vacuum, spraying dry obtains medicated powder.
The present invention the basis of medicated powder after the drying can add the adjuvant pharmaceutically allowed, and makes other dosage form, as multiple dosage forms such as pill, tablet, capsule, oral liquid, drop pill, sustained-release preparations.
clinical data
Object of study
With reference to the diagnostic criteria that nineteen ninety-five CAIM's peripheral vascular disease Professional Committee works out, it is the simple deep venous thrombosis of lower limbs person of acute stage mixed type that case standard is included in this research in, and one-sided limbs morbidity, the course of disease is within 15d.Exclusion standard: do not meet above-mentioned standard and have hemorrhage or bleeding tendency person.200 examples are the acute stage DVT patient gone to a doctor in Hospital Attached to Shandong Chinese Medical Univ. year November in January, 2009 to 2010, and random digits table is divided into experimental group and positive controls.Experimental group patient 100 example, wherein male 58 example, women 42 example, the age (50 ± 14) year, 22 ~ 80 years old.Positive controls patient 100 example, male 54 example, women 46 example, the age (49 ± 13) year, 24 ~ 80 years old.2 groups of intercurrent disease positions, disease time compare without significant difference (
p>0.05).
Clinical manifestation;
1. symptom: thick swollen, pain, shank distending pain (heavy or light), groin pain, femoral triangle district tenderness,
Chest pain, out of breath, cough uncomfortable in chest, spitting of blood, heating, large dry stool;
2. sign: Pi Wen, region superficial vein filling, groin tenderness, femoral triangle district tenderness, Homans levy;
Drugs
Chinese medicine of the present invention, raw material of Chinese medicine derives from Hospital Attached to Shandong Chinese Medical Univ.'s Pharmaceutical Department.Urokinase injection (urokinase for injection) Li Zhu pharmaceutical factory, the accurate word H44020645 of traditional Chinese medicines, often props up 100,000 U; Low molecular heparin calcium injection (low-molecular-weight heparins calcium injection), GlaxoSmithKline PLC company, import drugs registration certificate H 20080480, often props up 0.4mL:4100AxaIU.
Administrated method
Positive controls gives quiet of urokinase 200,000 U, once a day, and continuous use 14d, low molecular heparin calcium 4100U subcutaneous injection, once a day, continuous use 14d.Experimental group is oral medicine of the present invention on the basis of positive controls medication, each potion, every day twice, continuous use 14d.
Observation index
(1) symptom such as pain, swollen sense, sense of heaviness, heating and color of the leather is dark red, Pi Wen increases, the expansion of pitting edema, superficial vein, femoral triangle district tenderness, Homan levies the positive, Neuhof levies the positive.(2) limb encloses mensuration: mixed type DVT patient thigh stage casing and shank stage casing limb enclose change obviously, and easily measure, so before the treatment and to measure on patient's patella upper limb shank stage casing, 15cm place limb under 15cm mid-thigh, patella lower edge after last medication and enclose.
Efficacy evaluation
Clinical cure: symptom, sign disappear, ultrasonic display thrombosis disappears (recanalization rate 50% ~ 100%), and blood flow, flow restoration are normal.Effective: symptom disappears substantially, sign is clearly better, and thrombosis obviously reduces (recanalization rate 30% ~ ﹤ 50%).Progressive: symptom, sign alleviate, and thrombosis reduces (recanalization rate 20% ~ ﹤ 30%).Invalid: symptom, sign are without improvement, and ultrasonic display thrombosis is without significant change (recanalization rate < 20%).Instrument adopts GE-LOGIQ7 color Doppler ultrasonography in diagnosis system.
Statistical analysis
Application SPSS11.5 software is analyzed, and enumeration data adopts
x 2inspection; Measurement data with
± s represents, adopts One Way-ANOVA variance analysis, compares and adopt the inspection of Turkey method between 2 groups; Dependency Pearson correlation analysis between data, correlation coefficient (
rvalue) be just, represent positive correlation,
rvalue is negative, represents negative correlation.Each group of data
p<0.05 is difference significance.
Result
Table 1 is treated clinical symptoms between rear group and is compared
Table 2 is treated training inspection between rear group and is compared
each group of limb encloses and comparespositive treatment group and experimental group mid-thigh limb encloses and shank stage casing limb encloses without significant difference before treatment; After treatment, mid-thigh limb encloses and shank stage casing limb encloses and significantly reduces, with before treatment, more all there were significant differences; After experimental group treatment, mid-thigh limb encloses and shank stage casing limb encloses that to reduce comparatively positive treatment group more obvious, in table 3.
table 3 each group limb encloses and compares
Analysis of variance compares between two: compare with positive treatment group,
a
p <0.05; Compare with before treatment after the treatment of experimental group, positive treatment group,
b p<0.01; After treatment, experimental group compares with positive treatment group,
c p<0.01.
comparitive study
Above clinical data display, medicine of the present invention has significant curative effect to venous thrombosis.Medicine of the present invention adopts the effective ingredient in decoction and alcohol sedimentation technique extraction medical material, under the prerequisite of abundant stripping ensureing effective ingredient, removes the impurity extracted as far as possible, decreases the dose of medicine, meanwhile, add the probability preparing multiple dosage form.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described further.
Embodiment 1
Medical material is taken: the Radix Astragali 10 parts, Folium Artemisiae Argyi 6 parts, Herba Leonuri 6 parts, Radix Arnebiae (Radix Lithospermi) 6 parts, Herba Artemisiae Scopariae 6 ~ 10 parts, the Radix Angelicae Dahuricae 4 parts, Flos Lonicerae 8 parts, Radix Paeoniae Rubra 4 parts, Cortex Moutan 4 parts, Radix Achyranthis Bidentatae 4 parts, Radix Salviae Miltiorrhizae 4 parts, Ramulus Cinnamomi 5 parts, Radix Angelicae Sinensis 5 parts, Radix Notoginseng 7 parts, Cortex Acanthopancis 6 parts, Herba Lycopodii 4 parts, Rhizoma Atractylodis 4 parts, 4 parts, Semen Persicae, 3 parts, Flos Carthami by following weight portion, be soaked in the water of 8 times of volumes, abundant immersion 8 hours, high pressure concentrates boiling machine 120 DEG C and decocts 90 minutes, leaches medicinal liquid; Add 5 times of volume water again, high pressure concentrates boiling machine 120 DEG C and decocts 90 minutes, leaches medicinal liquid; The medicinal liquid leached twice merges, and heating is concentrated, and adding ethanol in concentrated solution to concentration of alcohol is 60%, fully mixes, precipitates overnight, leaching supernatant; Adding ethanol in precipitation to concentration of alcohol is 75%, fully mixes, precipitates overnight, leaching supernatant; Adding ethanol in precipitation to concentration of alcohol is 85%, fully mixes, precipitates overnight, leaching supernatant.Concentrated by the supernatant of three precipitate with ethanol leachings mixing final vacuum, spraying dry obtains medicated powder.
Claims (2)
1. treat a Chinese medicine for venous thrombosis, it is characterized in that, be prepared from by following weight portion crude drug:
The Radix Astragali 10 parts, Folium Artemisiae Argyi 6 parts, Herba Leonuri 6 parts, Radix Arnebiae (Radix Lithospermi) 6 parts, Herba Artemisiae Scopariae 6 ~ 10 parts, the Radix Angelicae Dahuricae 4 parts, Flos Lonicerae 8 parts, Radix Paeoniae Rubra 4 parts, Cortex Moutan 4 parts, Radix Achyranthis Bidentatae 4 parts, Radix Salviae Miltiorrhizae 4 parts, Ramulus Cinnamomi 5 parts, Radix Angelicae Sinensis 5 parts, Radix Notoginseng 7 parts, Cortex Acanthopancis 6 parts, Herba Lycopodii 4 parts, Rhizoma Atractylodis 4 parts, 4 parts, Semen Persicae, 3 parts, Flos Carthami.
2. Chinese medicine according to claim 1, is characterized in that, takes above medical material by weight, is soaked in the water of 8 times of volumes, fully soaks 8 hours, and high pressure concentrates boiling machine 120 DEG C and decocts 90 minutes, leaches medicinal liquid; Add 5 times of volume water again, high pressure concentrates boiling machine 120 DEG C and decocts 90 minutes, leaches medicinal liquid; The medicinal liquid leached twice merges, and heating is concentrated, and adding ethanol in concentrated solution to concentration of alcohol is 60%, fully mixes, precipitates overnight, leaching supernatant; Adding ethanol in precipitation to concentration of alcohol is 75%, fully mixes, precipitates overnight, leaching supernatant; Adding ethanol in precipitation to concentration of alcohol is 85%, fully mixes, precipitates overnight, leaching supernatant; Concentrated by the supernatant of three precipitate with ethanol leachings mixing final vacuum, spraying dry obtains medicated powder.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104667181A (en) * | 2015-02-10 | 2015-06-03 | 青岛市中心医院 | Traditional Chinese medicine for treating sequela of deep venous thrombosis |
| CN104740168A (en) * | 2015-04-01 | 2015-07-01 | 青岛大学附属医院 | Traditional Chinese medicine formula for treating phlebothrombosis after cesarean section |
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| CN102727615A (en) * | 2012-07-06 | 2012-10-17 | 王彬 | Traditional Chinese medicine for treating deep venous thrombosis and method for preparing traditional Chinese medicine |
| CN103110728A (en) * | 2013-03-21 | 2013-05-22 | 高思山 | Traditional Chinese medicine for treating deep venous thrombosis and preparation method of traditional Chinese medicine |
| CN103356817A (en) * | 2012-04-02 | 2013-10-23 | 韩凤云 | Formula for treating acute thrombophlebitis |
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| CN1340351A (en) * | 2000-08-31 | 2002-03-20 | 张泽国 | Powdered medicine 'Tongluosan' and its preparing process |
| CN103356817A (en) * | 2012-04-02 | 2013-10-23 | 韩凤云 | Formula for treating acute thrombophlebitis |
| CN102727615A (en) * | 2012-07-06 | 2012-10-17 | 王彬 | Traditional Chinese medicine for treating deep venous thrombosis and method for preparing traditional Chinese medicine |
| CN103110728A (en) * | 2013-03-21 | 2013-05-22 | 高思山 | Traditional Chinese medicine for treating deep venous thrombosis and preparation method of traditional Chinese medicine |
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| CN104667181A (en) * | 2015-02-10 | 2015-06-03 | 青岛市中心医院 | Traditional Chinese medicine for treating sequela of deep venous thrombosis |
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Application publication date: 20150204 |