CN104547833A - Orifice-opening nerve-soothing agent for improving intelligence of patients suffering from mental retardation and preparation method of orifice-opening nerve-soothing agent - Google Patents

Abstract

The invention discloses an orifice-opening nerve-soothing agent for improving intelligence of patients suffering from mental retardation. The agent is prepared from the following main raw materials in parts by weight: 15-20 parts of angelica sinensis, 10-15 parts of poria with hostwood, 1-3 parts of calculus bovis factitius, 8-12 parts of fructus galangae, 9-15 parts of fructus viticis, 15-30 parts of the fruit of Chinese wolfberry, 15-30 parts of cassia twig, 15-30 parts of fructus alpiniae oxyphyllae, 9-15 parts of Astragali Complanati Semen, 10-20 parts of cortex albiziae, 6-9 parts of Korean mondshood root, 15-20 parts of rhizoma acori graminei, 15-20 parts of lotus leaf, 3-6 parts of ruddle and 10-20 parts of polygala tenuifolia. The agent disclosed by the invention has the effects of promoting blood circulation to remove blood stasis, tonifying heart and kidney, replenishing essence and nourishing marrow and benefiting qi and nourishing blood and has an excellent curative effect of relieving mental retardation.

Description

improve sensible medicament and the preparation method of calming the nerves of retarded patient's intelligence

Technical field

The present invention relates to traditional Chinese medicine field, particularly relate to a kind of sensible medicament and preparation method of calming the nerves improving retarded patient's intelligence.

Background technology

Mental retardation occurs in developmental stage (referring generally to under-18s), and intellectual function is starkly lower than level of the same age, simultaneously with one group of disease of adaptive behavior defect.IQ (IQ) is lower than crowd's average 2.0 standard deviation (the IQ average of crowd is decided to be 100, and the IQ value of a standard deviation is 15), and general IQ is at 70(or 75) below be intelligence and be starkly lower than average level.Adaptive behavior comprises personal lifestyle ability and fulfils Social Responsibility two aspect.Mental retardation has various title: psychiatry is called mental retardation, oligophrenia, mental defect; Education, psychology are called mental retardation, intellectual deficiency; Pediatrics are called mental retardation, mental retardation, intelligent development obstacle; Special Education is called retarded, intelligent disability.

Generally mental retardation to be divided into slightly according to IQ, adaptive behavior defect, moderate, severe and pole severe level Four.1. low (psychiatry is also known as stupid): the IQ of mild mental is 50-70, defect that adaptive behavior is slight, and it is slightly slow to grow compared with normal in one's early years, and does not resemble normal youngster active, lacks interest to surrounding.Do things or follow rules docilely, or action is rough; Speech is grown slightly late, and abstractness vocabulary is grasped few; Analysis ability is poor, and problem of perception is shallow; School grade comparatively normal children is poor, energy reciting text, but can not correctly use, and arithmetic word problem completes difficulty; Reading and the billboard ability of practical tips and practicality can be obtained by specific education; General housework and simple specific works can be made after growing up; Lack one's own judgment, dependency is strong when anything crops up, is bad to deal with extraneous change, is subject to other people impact and domination; Society can be adapted under guidance.2. moderate mental retardation (also known as dull-witted): IQ is 35-49, adaptive behavior moderate defects, and whole growth compared with normal is slow; Language function hypoplasia, tells word unclear, and vocabulary is poor, and can only carry out simple concrete thinking, abstract conception is not easily set up; Poor to surrounding resolving ability, surface and the fragment phenomenon of things can only be familiar with; Reading and calculating aspect can not make progress; Through long-term business initiatives, education and training, simple life can be learned, basic hygienic habit, safety custom and simple hand skill.3. severe mental retardation (also known as imbecility): IQ is 20-34, adaptive behavior severe defect, in one's early years each side hypoevolutism; Pronounce ambiguous, speech is few, self-expression ability extreme difference; Abstract conception lacks, and understandability is low, emotional infantility; Action is very clumsy, has certain protection capability, can hide obvious danger; Through the habit training of system, simple life and hygienic habit can be formed, but living needs other people look after; When growing up, a little fixing and the simplest physical work can be done under supervision.4. pole severe mental retardation (also known as idiot): IQ is lower than 20, and adaptive behavior is defect extremely, and to surrounding, all do not understand; Lack language function, can cry out " father ", " mother " etc. at most, but really can not recognize parents, normal is unconscious yelping; Lack the instinct of self-protection, do not know to hide obvious danger, emotional responses is original; Sensation and consciousness obviously go down, and the remarkable obstacle of motor function, has one's fingers all thumbs or can not walk throughout one's life, often has multiply handicapped and epilepsy recurrent exerbation; Personal lifestyle can not process, and majority is die an early death, and survivor can respond to the Training Skills of trick.

At present; treat retarded medicine and method little; for the problems referred to above; the Chinese medicine preparation that patent document discloses a kind for the treatment of and raising intelligence of publication number CN 1352958 A (application number 00130239.6), the medicament that it is mainly made up of the material medicine of following parts by weight: Rhizoma Gastrodiae 10-30g, Ganoderma 10-30g, Semen Ziziphi Spinosae (parched) 10-20g, Semen Platycladi 6-10g, Radix Polygalae 6-10g, Cordyceps 3-6g, Calculus Bovis 1-3g, Rhizoma Alismatis 6-10g.Publication number CN 1151304 A(application number 95118400.8) patent document discloses a kind of pure and Natural intelligence enhancing agent, newfound a kind of medicine and pure natural nutritional type brain-tonifying health product for the treatment of retarded patient, this medicine or health care strain from Papilionaceae F. cauliflora Hemsl. plant through the former powder of F. cauliflora Hemsl. (be called for short IAP) that high-tech technology is extracted.Publication number CN 101347557 A(application number 200810118370.X) patent document discloses a kind of pharmaceutical composition for brain-care and its preparation method and application, mainly prepared by the raw material of following weight portion: Rhizoma Chuanxiong 4-6 part, Radix Salviae Miltiorrhizae 4-6 part, Arisaema Cum Bile 0.4-2 part, Radix Et Rhizoma Rhei 1-2 part, Pheretima 1-3 part, Fructus Ligustri Lucidi 2-4 part.

The prior art comprising above-mentioned patent documentation is also short of in treatment is retarded very much, although prior art possesses some special knowledge in treatment is retarded, specific aim is not strong, and curative effect is indefinite.

Summary of the invention

For the deficiencies in the prior art, an object of the present invention is to provide a kind of sensible medicament of calming the nerves improving retarded patient's intelligence, adopts Chinese crude drug comparatively common in the localities as raw material, can repair and supplementary cranial nerve, activate brain cell, promote the ability of brain cell regeneration.Another object of the present invention is just to provide the preparation method of above-mentioned sensible medicament of calming the nerves.

Above-mentioned purpose of the present invention is achieved through the following technical solutions:

Improve the sensible medicament of calming the nerves of retarded patient's intelligence, take off the primary raw material stating weight proportion and be prepared from: Radix Angelicae Sinensis 15-20 part; Poria cum Radix Pini 10-15 part; Artificial Calculus Bovis 1-3 part; Fructus Galangae 8-12 part; Fructus Viticis 9-15 part; Fructus Lycii 15-30 part; Ramulus Cinnamomi 15-30 part; Fructus Alpiniae Oxyphyllae 15-30 part; Semen Astragali Complanati 9-15 part; Cortex Albiziae 10-20 part; Radix Aconiti Coreani 6-9 part; Rhizoma Acori Graminei 15-20 part; Folium Nelumbinis 15-20 part; Haematitum 3-6 part; Radix Polygalae 10-20 part.

Improve the sensible medicament of calming the nerves of retarded patient's intelligence, preferred scheme is, takes off the primary raw material stating weight proportion and is prepared from: Radix Angelicae Sinensis 16-19 part; Poria cum Radix Pini 11-14 part; Artificial Calculus Bovis 1.5-2.5 part; Fructus Galangae 9-11 part; Fructus Viticis 11-13 part; Fructus Lycii 20-25 part; Ramulus Cinnamomi 20-25 part; Fructus Alpiniae Oxyphyllae 20-25 part; Semen Astragali Complanati 11-13 part; Cortex Albiziae 13-17 part; Radix Aconiti Coreani 7-8 part; Rhizoma Acori Graminei 16-19 part; Folium Nelumbinis 16-19 part; Haematitum 4-5 part; Radix Polygalae 13-17 part.

Improve the sensible medicament of calming the nerves of retarded patient's intelligence, the scheme be more preferably is, takes off the primary raw material stating weight proportion and is prepared from: Radix Angelicae Sinensis 18 parts; Poria cum Radix Pini 12 parts; Artificial Calculus Bovis 2 parts; Fructus Galangae 10 parts; Fructus Viticis 12 parts; Fructus Lycii 22 parts; Ramulus Cinnamomi 22 parts; Fructus Alpiniae Oxyphyllae 22 parts; Semen Astragali Complanati 12 parts; Cortex Albiziae 15 parts; Radix Aconiti Coreani 7.5 parts; Rhizoma Acori Graminei 18 parts; 18 parts, Folium Nelumbinis; Haematitum 4.5 parts; Radix Polygalae 15 parts.

Present invention also offers the preparation method sensible medicament of calming the nerves of retarded for above-mentioned improvement patient's intelligence being made pharmaceutically acceptable capsule, granule, pill and tablet.

The preparation method of the sensible sedative agent capsules of described improvement retarded patient intelligence, step is as follows:

(1) Haematitum is placed in mortar, grind into powder, is placed in glass container, add water stirring, inclines and get suspension, the coarse powder of sinking as above method repeatable operation 2-3 time, discard impurity, merge suspension, leave standstill 4-6 hour, the clear water on upper strata of inclining, get precipitation to dry, porphyrize, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(2) Radix Angelicae Sinensis, Radix Aconiti Coreani and Radix Polygalae are cut into the sheet of 0.3-0.5mm, are placed in non iron container, add the sorghum wine of 40-50o, soak 2-4 hour, put into and steam container water proof heating 2-3 hour;

(3) Poria cum Radix Pini, Fructus Galangae, Fructus Viticis and Semen Astragali Complanati are placed in glass container, soak and (preferably soak 3.5-4.5 hour in 3-5 hour, be more preferably immersion 4 hours), be placed in marmite, add step (2) gains, Fructus Lycii, Ramulus Cinnamomi, Fructus Alpiniae Oxyphyllae, Cortex Albiziae, Rhizoma Acori Graminei and Folium Nelumbinis, decoct with water twice, each decoction (preferably decocts 33-37 minute in 30-40 minute at every turn, be more preferably each decoction 35 minutes), merging filtrate;

(4) step (1) gained fine powder and artificial Calculus Bovis are joined in step (3) gained filtrate, mix homogeneously, be concentrated into relative density 1.10-1.20(45 DEG C) thick paste (be preferably concentrated into the thick paste of relative density 1.12-1.18, be more preferably the thick paste being concentrated into relative density 1.15), make the namely loose soft material that hands pinches agglomerating pressure, dry, pulverize, obtain medicated powder;

(5) step (4) gained medicated powder is measured according to 0.4-0.6g/ grain (preferred 0.45-0.55g/ grain, is more preferably 0.5g/ grain), be processed into capsule according to the preparation for processing of capsule.

According to preparation method recited above, preferred scheme is: the sorghum wine of the preferred 43-47o of step (2), is more preferably the sorghum wine of 45o.

Instructions of taking: each 2-4 grain, every day 2-3 time, 20 days courses for the treatment of.

The preparation method of the sensible medicament granule of calming the nerves of described improvement retarded patient intelligence, step is as follows:

(1) Haematitum is placed in mortar, grind into powder, is placed in glass container, add water stirring, inclines and get suspension, the coarse powder of sinking as above method repeatable operation 2-3 time, discard impurity, merge suspension, leave standstill 4-6 hour, the clear water on upper strata of inclining, get precipitation to dry, porphyrize, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(2) Radix Angelicae Sinensis, Radix Aconiti Coreani and Radix Polygalae are cut into the sheet of 0.3-0.5mm, be placed in non iron container, add the sorghum wine (sorghum wine of preferred 43-47o is more preferably the sorghum wine of 45o) of 40-50o, soak 2-4 hour, put into and steam container water proof heating 2-3 hour;

(3) Poria cum Radix Pini, Fructus Galangae, Fructus Viticis and Semen Astragali Complanati are placed in glass container, soak and (preferably soak 3.5-4.5 hour in 3-5 hour, be more preferably immersion 4 hours), be placed in marmite, add step (2) gains, Fructus Lycii, Ramulus Cinnamomi, Fructus Alpiniae Oxyphyllae, Cortex Albiziae, Rhizoma Acori Graminei and Folium Nelumbinis, decoct with water twice, each decoction (preferably decocts 33-37 minute in 30-40 minute at every turn, be more preferably each decoction 35 minutes), merging filtrate;

(4) step (1) gained fine powder and artificial Calculus Bovis are joined in step (3) gained filtrate; mix homogeneously; be concentrated into relative density 1.10-1.20(45 DEG C) thick paste (be preferably concentrated into the thick paste of relative density 1.12-1.18; be more preferably the thick paste being concentrated into relative density 1.15); add simple syrup, mixing, makes uniform granule; sterile packaged, every parcel 6g.

According to preparation method recited above, preferred scheme is: the consumption of the preferred simple syrup of step (4) is the 10%-20% of thick paste quality, and the consumption being more preferably simple syrup is 15% of thick paste quality.

Instructions of taking: each parcel, takes after melting, every day 2-3 time, 20 days courses for the treatment of by the warm water of 35-45 DEG C.

The preparation method of the sensible medicament pill of calming the nerves of described improvement retarded patient intelligence, step is as follows:

(1) Haematitum is placed in mortar, grind into powder, is placed in glass container, add water stirring, inclines and get suspension, the coarse powder of sinking as above method repeatable operation 2-3 time, discard impurity, merge suspension, leave standstill 4-6 hour, the clear water on upper strata of inclining, get precipitation to dry, porphyrize, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(2) Radix Angelicae Sinensis, Radix Aconiti Coreani and Radix Polygalae are cut into the sheet of 0.3-0.5mm, be placed in non iron container, add the sorghum wine (sorghum wine of preferred 43-47o is more preferably the sorghum wine of 45o) of 40-50o, soak 2-4 hour, put into and steam container water proof heating 2-3 hour;

(3) Poria cum Radix Pini, Fructus Galangae, Fructus Viticis and Semen Astragali Complanati are placed in glass container, soak and (preferably soak 3.5-4.5 hour in 3-5 hour, be more preferably immersion 4 hours), be placed in marmite, add step (2) gains, Fructus Lycii, Ramulus Cinnamomi, Fructus Alpiniae Oxyphyllae, Cortex Albiziae, Rhizoma Acori Graminei and Folium Nelumbinis, decoct with water twice, each decoction (preferably decocts 33-37 minute in 30-40 minute at every turn, be more preferably each decoction 35 minutes), merging filtrate;

(4) step (1) gained fine powder and artificial Calculus Bovis are joined in step (3) gained filtrate, mix homogeneously, be concentrated into relative density 1.10-1.20(45 DEG C) thick paste (be preferably concentrated into the thick paste of relative density 1.12-1.18, be more preferably the thick paste being concentrated into relative density 1.15), make the namely loose soft material that hands pinches agglomerating pressure, dry, pulverize, obtain medicated powder;

(5) Mel is placed in pot, temper with slow fire, endure to thick Deng Mel, add the medicated powder of step (4) gained, fully mix into ointment thoroughly, make that color and luster is consistent, evenly (preferred diameter is 3-5mm to size, being more preferably diameter is 4mm) elementary finished product ball, be placed in baking oven and slowly dry, take out, In Shadely naturally to dry in the shade, sterile packaged.

Instructions of taking: each 6-10 ball, every day 2-3 time, 20 days courses for the treatment of.

According to preparation method recited above, preferred scheme is: step (5) preferably Mel consumption is the 10%-20% of medicated powder quality, be more preferably that Mel consumption is medicated powder quality 15%.

The preparation method of the sensible medicament tablet of calming the nerves of described improvement retarded patient intelligence, step is as follows:

(1) Haematitum is placed in mortar, grind into powder, is placed in glass container, add water stirring, inclines and get suspension, the coarse powder of sinking as above method repeatable operation 2-3 time, discard impurity, merge suspension, leave standstill 4-6 hour, the clear water on upper strata of inclining, get precipitation to dry, porphyrize, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(2) Radix Angelicae Sinensis, Radix Aconiti Coreani and Radix Polygalae are cut into the sheet of 0.3-0.5mm, be placed in non iron container, add the sorghum wine (sorghum wine of preferred 43-47o is more preferably the sorghum wine of 45o) of 40-50o, soak 2-4 hour, put into and steam container water proof heating 2-3 hour;

(3) Poria cum Radix Pini, Fructus Galangae, Fructus Viticis and Semen Astragali Complanati are placed in glass container, soak and (preferably soak 3.5-4.5 hour in 3-5 hour, be more preferably immersion 4 hours), be placed in marmite, add step (2) gains, Fructus Lycii, Ramulus Cinnamomi, Fructus Alpiniae Oxyphyllae, Cortex Albiziae, Rhizoma Acori Graminei and Folium Nelumbinis, decoct with water twice, each decoction (preferably decocts 33-37 minute in 30-40 minute at every turn, be more preferably each decoction 35 minutes), merging filtrate;

(4) step (1) gained fine powder and artificial Calculus Bovis are joined in step (3) gained filtrate; mix homogeneously; be concentrated into relative density 1.10-1.20(45 DEG C) thick paste (be preferably concentrated into the thick paste of relative density 1.12-1.18; be more preferably the thick paste being concentrated into relative density 1.15); make the namely loose soft material that hands pinches agglomerating pressure; with fashion of extrusion by 18-26 eye mesh screen (preferred 20-24 eye mesh screen excessively; be more preferably 22 eye mesh screens); make single-size; dry; be pressed into lamellar, sugar coating.

Instructions of taking: each 2-3 sheet, every day 2-3 time, 20 days courses for the treatment of.

Technical advantage of the present invention is mainly reflected in:

1, the present invention adopts pure natural draft purification of tcm to form, and have blood circulation promoting and blood stasis dispelling, invigorating heart and kidney, marrow is supported in replenishing essence, effect of benefiting qi and nourishing blood, has good curative effect to alleviation is retarded.

2, the present invention acts on cerebral cortex, has activation, protects and repair the effect of neurocyte, activate brain cell, promote the ability of brain cell regeneration.

3, medicine source of the present invention is easy to get, and medical material is with low cost, can alleviate patient economy burden, and ordinary people can afford.

4, adopt Chinese crude drug comparatively common in the localities as raw material, have no side effect.

Detailed description of the invention

Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.

embodiment 1improve the sensible medicament of calming the nerves of retarded patient's intelligence, take off and state primary raw material and be prepared from (getting 50g for every part): Radix Angelicae Sinensis 15 parts; Poria cum Radix Pini 10 parts; Artificial Calculus Bovis 1 part; Fructus Galangae 8 parts; Fructus Viticis 9 parts; Fructus Lycii 15 parts; Ramulus Cinnamomi 15 parts; Fructus Alpiniae Oxyphyllae 15 parts; Semen Astragali Complanati 9 parts; Cortex Albiziae 10 parts; Radix Aconiti Coreani 6 parts; Rhizoma Acori Graminei 15 parts; 15 parts, Folium Nelumbinis; Haematitum 3 parts; Radix Polygalae 10 parts.

The preparation method of the sensible sedative agent capsules of above-mentioned improvement retarded patient intelligence, step is as follows:

(1) be placed in mortar by Haematitum, grind into powder, be placed in glass container, add water stirring, inclines and get suspension, the coarse powder sunk as above method repeatable operation 2 times, discards impurity, merges suspension, leaves standstill 5 hours, incline the clear water on upper strata, gets precipitation and dry, porphyrize, crosses 140 mesh sieves;

(2) Radix Angelicae Sinensis, Radix Aconiti Coreani and Radix Polygalae are cut into the sheet of 0.4mm, are placed in non iron container, add the sorghum wine of 45o, soak 3 hours, put into and steam container water proof and heat 2 hours;

(3) Poria cum Radix Pini, Fructus Galangae, Fructus Viticis and Semen Astragali Complanati are placed in glass container, soak 4 hours, be placed in marmite, add step (2) gains, Fructus Lycii, Ramulus Cinnamomi, Fructus Alpiniae Oxyphyllae, Cortex Albiziae, Rhizoma Acori Graminei and Folium Nelumbinis, decoct with water twice, each decoction 35 minutes, merging filtrate;

(4) step (1) gained fine powder and artificial Calculus Bovis are joined in step (3) gained filtrate, mix homogeneously, is concentrated into relative density 1.15(45 DEG C) thick paste, make the namely loose soft material that hands pinches agglomerating pressure, dry, pulverize, obtain medicated powder;

(5) step (4) gained medicated powder is measured according to 0.5g/ grain, be processed into capsule according to the preparation for processing of capsule.

Instructions of taking: each 3, every day 3 times, 20 days courses for the treatment of.

model case onesoviet Union XX, man, 9 years old, Laiwu City people from Laicheng district, Shandong Province.Just LEARNING TO WALK more than 3 years old, just lifts up one's voice for 5 years old.After kindergarten, teacher reflects him, and what all be can not learn, and does not also play together with child, is even him name and does not all have reaction.Remove examination in hospital, be diagnosed as mental retardation disease, be commonly called as retarded.From then on, one family starts to rush about, and within several years, get off can be described as and go bankrupt or broke, the state of an illness is not but felt any better, and can't to count up to the numeral within 50 more than 8 years old continuously.Usually dull expression, bradykinesia, can not number, and frequent sialorrhea, repeats to speak, do not listen instruction, can't take care of oneself.

Afterwards through the introduction of an infants ' parents, recognize that the present invention improves the curative effect of the sensible medicament of calming the nerves of retarded patient's intelligence pretty good, so take after gained of the present invention improves 2 courses for the treatment of of sensible sedative agent capsules (embodiment 1) of retarded patient's intelligence, the state of an illness is clearly better gradually.Continue again to take further consultation after 3 courses for the treatment of, oneself can wear the clothes, have a meal, and understandability, sports coordination ability comparatively before there is larger improvement, can say grandparents, Papa and Mama and the name of oneself, can oneself defecation, basic living can be taken care of oneself.

embodiment 2improve the sensible medicament of calming the nerves of retarded patient's intelligence, take off and state primary raw material and be prepared from (getting 45g for every part): Radix Angelicae Sinensis 16 parts; Poria cum Radix Pini 11 parts; Artificial Calculus Bovis 1.5 parts; Fructus Galangae 9 parts; Fructus Viticis 11 parts; Fructus Lycii 20 parts; Ramulus Cinnamomi 20 parts; Fructus Alpiniae Oxyphyllae 20 parts; Semen Astragali Complanati 11 parts; Cortex Albiziae 13 parts; Radix Aconiti Coreani 7 parts; Rhizoma Acori Graminei 16 parts; 16 parts, Folium Nelumbinis; Haematitum 4 parts; Radix Polygalae 13 parts.

The preparation method of the sensible medicament granule of calming the nerves of above-mentioned improvement retarded patient intelligence, step is as follows:

(1) be placed in mortar by Haematitum, grind into powder, be placed in glass container, add water stirring, inclines and get suspension, the coarse powder sunk as above method repeatable operation 2 times, discards impurity, merges suspension, leaves standstill 5 hours, incline the clear water on upper strata, gets precipitation and dry, porphyrize, crosses 140 mesh sieves;

(2) Radix Angelicae Sinensis, Radix Aconiti Coreani and Radix Polygalae are cut into the sheet of 0.4mm, are placed in non iron container, add the sorghum wine of 45o, soak 3 hours, put into and steam container water proof and heat 3 hours;

(3) Poria cum Radix Pini, Fructus Galangae, Fructus Viticis and Semen Astragali Complanati are placed in glass container, soak 4 hours, be placed in marmite, add step (2) gains, Fructus Lycii, Ramulus Cinnamomi, Fructus Alpiniae Oxyphyllae, Cortex Albiziae, Rhizoma Acori Graminei and Folium Nelumbinis, decoct with water twice, each decoction 35 minutes, merging filtrate;

(4) step (1) gained fine powder and artificial Calculus Bovis are joined in step (3) gained filtrate, mix homogeneously, is concentrated into relative density 1.15(45 DEG C) thick paste, add simple syrup, mixing, make uniform granule, sterile packaged, every parcel 6g.

Instructions of taking: each parcel, takes after melting, every day 3 times, 20 days courses for the treatment of by the warm water of 35-45 DEG C.

model case twoburnt XX, man, 8 years old, Weifang City of Shandong Province from Kuiwen District.Since birth till now, cannot shake right rolling in a left side, automatic control ground, walk very difficult, defecation can not be taken care of oneself, and needs adult to stare at always, sialorrhea of also often laughing foolishly, and communication capability is poor especially, does not substantially understand adult's word always.Remove examination in hospital, be diagnosed as retarded.

Take after gained of the present invention improves 2 courses for the treatment of of sensible medicament granule of calming the nerves (embodiment 2) of retarded patient's intelligence, the state of an illness is clearly better gradually.After continuing again to take 2 courses for the treatment of, substantially can oneself defecation, basic living can be taken care of oneself, and understandability, sports coordination ability comparatively before have larger improvement.

embodiment 3improve the sensible medicament of calming the nerves of retarded patient's intelligence, take off and state primary raw material and be prepared from (getting 20g for every part): Radix Angelicae Sinensis 19 parts; Poria cum Radix Pini 14 parts; Artificial Calculus Bovis 2.5 parts; Fructus Galangae 11 parts; Fructus Viticis 13 parts; Fructus Lycii 25 parts; Ramulus Cinnamomi 25 parts; Fructus Alpiniae Oxyphyllae 25 parts; Semen Astragali Complanati 13 parts; Cortex Albiziae 17 parts; Radix Aconiti Coreani 8 parts; Rhizoma Acori Graminei 19 parts; 19 parts, Folium Nelumbinis; Haematitum 5 parts; Radix Polygalae 17 parts.

The preparation method of the sensible medicament pill of calming the nerves of above-mentioned improvement retarded patient intelligence, step is as follows:

(1) be placed in mortar by Haematitum, grind into powder, be placed in glass container, add water stirring, inclines and get suspension, the coarse powder sunk as above method repeatable operation 3 times, discards impurity, merges suspension, leaves standstill 5 hours, incline the clear water on upper strata, gets precipitation and dry, porphyrize, crosses 140 mesh sieves;

(2) Radix Angelicae Sinensis, Radix Aconiti Coreani and Radix Polygalae are cut into the sheet of 0.4mm, are placed in non iron container, add the sorghum wine of 45o, soak 3 hours, put into and steam container water proof and heat 3 hours;

(3) Poria cum Radix Pini, Fructus Galangae, Fructus Viticis and Semen Astragali Complanati are placed in glass container, soak 4 hours, be placed in marmite, add step (2) gains, Fructus Lycii, Ramulus Cinnamomi, Fructus Alpiniae Oxyphyllae, Cortex Albiziae, Rhizoma Acori Graminei and Folium Nelumbinis, decoct with water twice, each decoction 35 minutes, merging filtrate;

(4) step (1) gained fine powder and artificial Calculus Bovis are joined in step (3) gained filtrate, mix homogeneously, is concentrated into relative density 1.15(45 DEG C) thick paste, make the namely loose soft material that hands pinches agglomerating pressure, dry, pulverize, obtain medicated powder;

(5) Mel is placed in pot, temper with slow fire, endure to thick Deng Mel, add the medicated powder of step (4) gained, fully mix into ointment thoroughly, make that color and luster is consistent, the elementary finished product ball of size evenly (diameter is 4mm), be placed in baking oven and slowly dry, take out, In Shadely naturally to dry in the shade, sterile packaged.

Instructions of taking: each 10 balls, every day 3 times, 20 days courses for the treatment of.

model case threewhite XX, female, 6 years old, Dezhou City Shandong Province people from Linyi County.Although more than 6 years old, IQ is similar with the child more than one or two years old.Usually express one's feelings very dull, the simple questions such as where, how old bradykinesia oneself has been all are not known, even to the ability that personage does not also distinguish, not being familiar with the Papa and Mama of oneself, to the ability that anything is not refused, can only determining whether to have enough with checking for feeding father and mother.Remove examination in hospital, be diagnosed as retarded.

Take after gained of the present invention improves 2 courses for the treatment of of sensible medicament pill of calming the nerves (embodiment 3) of retarded patient's intelligence, symptom is clearly better, and can react to some extent sometimes to surroundings, when funny she play time, occasional is laughed at.After continuing again to take 2 courses for the treatment of, substantially can oneself defecation, and also understandability, sports coordination ability comparatively before have larger improvement.

embodiment 4improve the sensible medicament of calming the nerves of retarded patient's intelligence, take off and state primary raw material and be prepared from (getting 10g for every part): Radix Angelicae Sinensis 18 parts; Poria cum Radix Pini 12 parts; Artificial Calculus Bovis 2 parts; Fructus Galangae 10 parts; Fructus Viticis 12 parts; Fructus Lycii 22 parts; Ramulus Cinnamomi 22 parts; Fructus Alpiniae Oxyphyllae 22 parts; Semen Astragali Complanati 12 parts; Cortex Albiziae 15 parts; Radix Aconiti Coreani 7.5 parts; Rhizoma Acori Graminei 18 parts; 18 parts, Folium Nelumbinis; Haematitum 4.5 parts; Radix Polygalae 15 parts.

The preparation method of the sensible medicament tablet of calming the nerves of above-mentioned improvement retarded patient intelligence, step is as follows:

(1) be placed in mortar by Haematitum, grind into powder, be placed in glass container, add water stirring, inclines and get suspension, the coarse powder sunk as above method repeatable operation 3 times, discards impurity, merges suspension, leaves standstill 5 hours, incline the clear water on upper strata, gets precipitation and dry, porphyrize, crosses 140 mesh sieves;

(2) Radix Angelicae Sinensis, Radix Aconiti Coreani and Radix Polygalae are cut into the sheet of 0.4mm, are placed in non iron container, add the sorghum wine of 45o, soak 3 hours, put into and steam container water proof and heat 3 hours;

(3) Poria cum Radix Pini, Fructus Galangae, Fructus Viticis and Semen Astragali Complanati are placed in glass container, soak 4 hours, be placed in marmite, add step (2) gains, Fructus Lycii, Ramulus Cinnamomi, Fructus Alpiniae Oxyphyllae, Cortex Albiziae, Rhizoma Acori Graminei and Folium Nelumbinis, decoct with water twice, each decoction 35 minutes, merging filtrate;

(4) step (1) gained fine powder and artificial Calculus Bovis are joined in step (3) gained filtrate; mix homogeneously; be concentrated into relative density 1.15(45 DEG C) thick paste; make the namely loose soft material that hands pinches agglomerating pressure; with fashion of extrusion by 22 eye mesh screens, make single-size, dry; be pressed into lamellar, sugar coating.

Instructions of taking: each 3, every day 3 times, 20 days courses for the treatment of.

The pharmacological effect of each crude drug is respectively:

Radix Angelicae Sinensis: sweet in the mouth, pungent, micro-hardship, warm in nature.Return liver, the heart, spleen channel.For the dry root of umbelliferae angelica.Having enriches blood invigorates blood circulation, menstruction regulating and pain relieving, effect of loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.

Poria cum Radix Pini: sweet in the mouth, light, property is put down.Be the Chinese medicine product of plant Poria, former plant multiparasitization is on Pinus massoniana Lamb or Duan Mu.There is effect of eliminating dampness by diuresis, spleen invigorating, mind calming.For mind calming, calm the nerves, diuretic, palpitation with fear of having a guilty conscience, forgetful, insomnia, infantile convulsion, dysuria.

Artificial Calculus Bovis: bitter in the mouth, micro-sweet.Being made up of bilein, cholic acid, Hyodeoxycholic Acid, taurine, bilirubin, cholesterol, trace element etc., is yellow loose powder.Have heat clearing away, removing toxic substances, reduces phlegm. effect of arresting convulsion.For tired hot delirium.In silence, children's is hot infantile convulsion suddenly, laryngopharynx swelling and pain, aphtha of the mouth and tongue, carbuncle furuncle for coma.

Fructus Galangae: acrid in the mouth, warm in nature.Return board, lung meridian.For the dry mature fruit of zingiberaceous plant Rhizoma Alpiniae Galangae.There is dampness cold expelling, effect helped digestion of being amusing.For coldness and pain in the epigastrium, food stagnation distension, vomiting lets out dirt, drinking too much.

Fructus Viticis: acrid in the mouth, hardship, cold nature.Return bladder, liver, stomach warp.For the dry mature fruit of Verbenaceae Vitex rotundifolia or wild pepper.There is dispelling wind and heat pathogens, effect of the clear sharp head.For anemopyretic cold headache, gingivitis, the many tear of conjunctival congestion, poor vision, has a dizzy spell.

Fructus Lycii: sweet in the mouth, property is put down.Return liver, kidney channel.For the dry mature fruit of plant of Solanaceae lycium barbarum.There is nourishing the liver and kidney, effect of replenishing vital essence to improve eyesight.For asthenia damage of essence, doctor's knee joint soreness, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.

Ramulus Cinnamomi: acrid in the mouth, sweet, warm in nature.GUIXIN, lung, urinary bladder channel.For the dry twig of canella Cortex Cinnamomi.There is diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, effect of the flat gas that spins.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.

Fructus Alpiniae Oxyphyllae: acrid in the mouth, warm in nature.Return spleen, kidney channel.For the dry mature fruit of zingiberaceous plant.Containing volatile oil: sesquiterpenoidss such as eucalyptol, zingiberene, zingiberols, containing abundant support one's family life B and the elements such as life C, and the manganese of trace, zinc, potassium, sodium, calcium, magnesium, phosphorus, ferrum, copper of supporting one's family.Have and warming spleen and stopping diarrhaly take the photograph saliva, effect of warming the kidney controlling nocturnal emission with astringent drugs reducing urination.Have loose bowels for spleen-cold syndrome, cold type of pain in abdomen, the many salivas of mouth, enuresis due to deficiency of the kidney, frequent micturition, seminal emission nebulousurine.

Semen Astragali Complanati: sweet in the mouth, warm in nature.For the seed of leguminous plant astragatus complanatus.There is the liver and the kidney tonifying, effect of improving eyesight controlling nocturnal emission with astringent drugs.For deficiency of the liver and kindey, soreness of waist and knee joint, blurred vision, seminal emission premature ejaculation, the enuresis, hematuria, leucorrhea is many, and lung committee kidney is cold, frequent micturition, energy improving eyesight, longue etc.

Cortex Albiziae: sweet in the mouth, property is put down.GUIXIN, liver, lung meridian.For the dry bark of leguminous plant Herba Albiziae.There is resolving stagnation for tranquilization, effect of promoting blood circulation and detumescence.For irritability, melancholy insomnia, lung abscess skin ulcer swells, and falls and flutters the pain of injury.

Radix Aconiti Coreani: Xin Gan, heat.Return lung, spleen two warp.For the tuber of Ranunculaceae Aconitum Radix Aconiti Coreani.Containing hypaconitine and the still undetermined Guan-fubase A of chemical constitution, guanfu base B, Radix Aconiti Coreani C prime, Radix Aconiti Coreani D prime and Radix Aconiti Coreani penta element.Dispel the wind expectorant, by cold-damp, and arresting convulsion epilepsy.Control middle wind-phlegm to stop up, facial hemiparalysis, headache, epilepsy, rheumatic arthralgia, tetanus, skin infection scabies, skin pruritus.

Rhizoma Acori Graminei: another name Rhizoma Acori Graminei, prosperous grass, spring snow, water Rhizoma Acori Graminei etc.Acrid in the mouth, hardship, warm in nature.GUIXIN, stomach warp.For the dry rhizome of acorus gramineus araceae plant.There is removing dampness appetizing, eliminating phlegm of having one's ideas straightened out, effect of refreshment Fructus Alpiniae Oxyphyllae.Not hungry for gastral cavity painful abdominal mass, a mouthful dysentery of keeping silent, the insane disease of coma, forgetful deafness.

Folium Nelumbinis: bitter in the mouth, property is put down.Return liver, spleen, stomach warp.For the dried leaves of nymphaeaceae plant lotus.There is clearing away summer-heat, sending up the lucid YANG, effect of cooling blood for hemostasis.For multiple hemorrhage and puerperal blood faints.

Haematitum: bitter in the mouth, sweet, property is put down.Return liver, stomach, heart born of the same parents warp.There is suppressing the hyperactive liver town inverse, effect of cooling blood for hemostasis.For eructation vomiting, dysphagia and regurgitation, asthma, infantile convulsion, spits blood, epistaxis, hemorrhoidal hamorrhage, hemorrhoid complicated by anal fistula, bleeding not during menses.

Radix Polygalae: bitter in the mouth, pungent, warm in nature.GUIXIN, kidney, lung meridian.For the dry root of milk wort Radix Polygalae or ovum leaf Radix Polygalae.There is Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, effect of detumescence.The insomnia and dreamful sleep caused for disarmony between the heart and kidney, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain.

test example:improve the examination of curative effect of the sensible medicament of calming the nerves (embodiment 4) of retarded patient's intelligence for gained of the present invention, we have done toxicity test and clinical trial, and concrete condition is as follows:

toxicity test acute toxicity testselect SPF level kunming mice, raise in square transparent mouse cage, the drinking-water that guarantee is sufficient and food, raise 2-3 days before experiment, to adapt to experimental situation, and observes its normal growth activity and health status.Need the feeding room to mice, cage tool, drinking bottle etc. to carry out disinfection before raising, before administration, fasting can't help water 12 hours.Select the mice 20 of normal health, male and female half and half, body weight 18-22g, ensure female not producing, without pregnant.Gastric perfusion needle is used to carry out gavage to mice: the sensible medicament tablet warm water of calming the nerves gained of the present invention being improved retarded patient's intelligence melts, gastric perfusion needle is inserted by animal bicker, general depth of needle 2.5-3cm, every mouse stomach 0.3ml medicinal liquid, the reaction of close observation mice after administration, observes 15 days, and experimental animal does not find poisoning manifestations, without dead, dissect obviously not abnormal, judge that the present invention improves the sensible medicament of calming the nerves of retarded patient's intelligence to the nontoxic level in the true border of Mouse Acute Toxicity.

long term toxicity testselect SPF level kunming mice, raise in square transparent mouse cage, the drinking-water that guarantee is sufficient and food, raise 2-3 days before experiment, to adapt to experimental situation, and observes its normal growth activity and health status.The feeding room to mice, cage tool, drinking bottle etc. is needed to carry out disinfection before raising.Before administration, fasting can't help water 12 hours.Select the mice 20 of normal health, male and female half and half, body weight 18-22g, same guarantee is female does not produce, without pregnant.Take the sensible medicament tablet of calming the nerves that gained of the present invention improves retarded patient's intelligence, melt with warm water, every mice controls dosage 1g every day, continuous use 7 weeks, and drug withdrawal was observed after 3 weeks, weigh weekly once during administration, can be observed amount of drinking water appetite all normal, body weight increases, without dead or moribund animals, the index such as hair, behavior, defecation, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of mice all has no significant effect, and internal organs naked eyes do not find difference change.Histological indications shows, medication 7 weeks and drug withdrawal be after 3 weeks, and Organs of Mice, all without obviously changing, illustrating that the present invention improves the sensible medicament of calming the nerves of retarded patient's intelligence very little to toxicity after mice long-term prescription, also not having difference to react, application safety after drug withdrawal.

clinical trial:in order to verify that gained of the present invention improves the curative effect of the sensible medicament of calming the nerves (embodiment 4) of retarded patient's intelligence, we have done contrast test in March ,-2011 in August, 2008.

General data: screening 200 routine retarded patients, man 106 example, female 94 example; Minimal ages 4 years old, max age 22 years old, 9.4 years old mean age; 4-10 year 135 people, 11-22 year 65 people.Be divided into experimental group and matched group Liang Ge group (wherein experimental group 150 people, matched group 50 people) at random.Two groups are compared there was no significant difference (P > 0.05), have comparability in sex, age, the course of disease, state of an illness scoring etc.

Diagnostic criteria: 1. intelligence is starkly lower than level of the same age, namely IQ is lower than average 2 standard deviations, below 70; 2. there is social skill, the adaptive functions defect such as verbal communication, daily life are looked after, individual stand-alone capability, its degree than child of the same age cultural context desired by standard much lower; 3. fell ill before 18 years old.4. Delayed motor, abnormal posture and postural reflex exception, dystonia, neural reflex are extremely.

Usage and dosage: two groups of patients unify dietary standards.Experimental group takes the sensible medicament tablet of calming the nerves that gained of the present invention improves retarded patient's intelligence, each 2, every day 3 times, 20 days courses for the treatment of.Matched group: adopt other treatment mode (as piracetam, divalvon-D sheet etc.), wherein piracetam: oral each 0.8-1.6g (2-4 sheet), every day 3 times, 4-8 week is a course for the treatment of; Child's consumption reduces by half.Divalvon-D sheet: each 0.1g-0.2g(1-2 sheet of oral adult), 3 times on the 1st; The each 0.05-0.1g of child (1/2-1 sheet), 3 times on the 1st.

Criterion of therapeutical effect: recovery from illness: promote more than 20 persons though reached normal intellect level after measured or do not reached normal intellect level IQ value (IQ).Effective: not reach normal intellect level after measured but IQ value (IQ) promotes 0-20 person.Invalid: IQ value (IQ) is substantially unchanged after measured.

5 courses for the treatment of of medication treatment, observe latter 1 year for the treatment of.Adopt the matched group of other treatment mode and take the Comparison of therapeutic that gained of the present invention improves the experimental group of the sensible medicament of calming the nerves of retarded patient's intelligence, result is as shown in table 1:

Table 1

efficacy analysis:as can be seen from Table 1, take the inefficiency that gained of the present invention improves the sensible medicament of calming the nerves of retarded patient's intelligence and be only 4%, cure rate is up to 70%, effective percentage is up to 96%, and adopt other treatment mode have 26% inefficiency, cure rate only reaches 38%, and effective percentage is also only 74%.Experiment shows that gained of the present invention improves the curative effect of the sensible medicament of calming the nerves of retarded patient's intelligence more significantly, and cure rate is high, and inefficiency is low.

Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (10)

1. improve the sensible medicament of calming the nerves of retarded patient's intelligence, it is characterized in that, take off the primary raw material stating weight proportion and be prepared from: Radix Angelicae Sinensis 15-20 part; Poria cum Radix Pini 10-15 part; Artificial Calculus Bovis 1-3 part; Fructus Galangae 8-12 part; Fructus Viticis 9-15 part; Fructus Lycii 15-30 part; Ramulus Cinnamomi 15-30 part; Fructus Alpiniae Oxyphyllae 15-30 part; Semen Astragali Complanati 9-15 part; Cortex Albiziae 10-20 part; Radix Aconiti Coreani 6-9 part; Rhizoma Acori Graminei 15-20 part; Folium Nelumbinis 15-20 part; Haematitum 3-6 part; Radix Polygalae 10-20 part.

2. the sensible medicament of calming the nerves of improvement according to claim 1 retarded patient intelligence, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: Radix Angelicae Sinensis 16-19 part; Poria cum Radix Pini 11-14 part; Artificial Calculus Bovis 1.5-2.5 part; Fructus Galangae 9-11 part; Fructus Viticis 11-13 part; Fructus Lycii 20-25 part; Ramulus Cinnamomi 20-25 part; Fructus Alpiniae Oxyphyllae 20-25 part; Semen Astragali Complanati 11-13 part; Cortex Albiziae 13-17 part; Radix Aconiti Coreani 7-8 part; Rhizoma Acori Graminei 16-19 part; Folium Nelumbinis 16-19 part; Haematitum 4-5 part; Radix Polygalae 13-17 part.

3. the sensible medicament of calming the nerves of improvement according to claim 1 retarded patient intelligence, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: Radix Angelicae Sinensis 18 parts; Poria cum Radix Pini 12 parts; Artificial Calculus Bovis 2 parts; Fructus Galangae 10 parts; Fructus Viticis 12 parts; Fructus Lycii 22 parts; Ramulus Cinnamomi 22 parts; Fructus Alpiniae Oxyphyllae 22 parts; Semen Astragali Complanati 12 parts; Cortex Albiziae 15 parts; Radix Aconiti Coreani 7.5 parts; Rhizoma Acori Graminei 18 parts; 18 parts, Folium Nelumbinis; Haematitum 4.5 parts; Radix Polygalae 15 parts.

4., according to the sensible medicament of calming the nerves of the arbitrary described improvement retarded patient intelligence of claim 1-3, it is characterized in that, this sensible medicament of calming the nerves is made pharmaceutically acceptable capsule, and preparation method is:

(1) Haematitum is placed in mortar, grind into powder, is placed in glass container, add water stirring, inclines and get suspension, the coarse powder of sinking as above method repeatable operation 2-3 time, discard impurity, merge suspension, leave standstill 4-6 hour, the clear water on upper strata of inclining, get precipitation to dry, porphyrize, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(2) Radix Angelicae Sinensis, Radix Aconiti Coreani and Radix Polygalae are cut into the sheet of 0.3-0.5mm, are placed in non iron container, add the sorghum wine of 40-50o, soak 2-4 hour, put into and steam container water proof heating 2-3 hour;

(3) Poria cum Radix Pini, Fructus Galangae, Fructus Viticis and Semen Astragali Complanati are placed in glass container, soak and (preferably soak 3.5-4.5 hour in 3-5 hour, be more preferably immersion 4 hours), be placed in marmite, add step (2) gains, Fructus Lycii, Ramulus Cinnamomi, Fructus Alpiniae Oxyphyllae, Cortex Albiziae, Rhizoma Acori Graminei and Folium Nelumbinis, decoct with water twice, each decoction (preferably decocts 33-37 minute in 30-40 minute at every turn, be more preferably each decoction 35 minutes), merging filtrate;

(4) step (1) gained fine powder and artificial Calculus Bovis are joined in step (3) gained filtrate, mix homogeneously, be concentrated into relative density 1.10-1.20(45 DEG C) thick paste (be preferably concentrated into the thick paste of relative density 1.12-1.18, be more preferably the thick paste being concentrated into relative density 1.15), make the namely loose soft material that hands pinches agglomerating pressure, dry, pulverize, obtain medicated powder;

(5) step (4) gained medicated powder is measured according to 0.4-0.6g/ grain (preferred 0.45-0.55g/ grain, is more preferably 0.5g/ grain), be processed into capsule according to the preparation for processing of capsule.

5. the preparation method of the sensible medicament of calming the nerves of improvement according to claim 4 retarded patient intelligence, is characterized in that: the sorghum wine of the preferred 43-47o of step (2), is more preferably the sorghum wine of 45o.

6., according to the sensible medicament of calming the nerves of the arbitrary described improvement retarded patient intelligence of claim 1-3, it is characterized in that, this sensible medicament of calming the nerves is made pharmaceutically acceptable granule, and preparation method is:

(1) Haematitum is placed in mortar, grind into powder, is placed in glass container, add water stirring, inclines and get suspension, the coarse powder of sinking as above method repeatable operation 2-3 time, discard impurity, merge suspension, leave standstill 4-6 hour, the clear water on upper strata of inclining, get precipitation to dry, porphyrize, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(2) Radix Angelicae Sinensis, Radix Aconiti Coreani and Radix Polygalae are cut into the sheet of 0.3-0.5mm, be placed in non iron container, add the sorghum wine (sorghum wine of preferred 43-47o is more preferably the sorghum wine of 45o) of 40-50o, soak 2-4 hour, put into and steam container water proof heating 2-3 hour;

(3) Poria cum Radix Pini, Fructus Galangae, Fructus Viticis and Semen Astragali Complanati are placed in glass container, soak and (preferably soak 3.5-4.5 hour in 3-5 hour, be more preferably immersion 4 hours), be placed in marmite, add step (2) gains, Fructus Lycii, Ramulus Cinnamomi, Fructus Alpiniae Oxyphyllae, Cortex Albiziae, Rhizoma Acori Graminei and Folium Nelumbinis, decoct with water twice, each decoction (preferably decocts 33-37 minute in 30-40 minute at every turn, be more preferably each decoction 35 minutes), merging filtrate;

(4) step (1) gained fine powder and artificial Calculus Bovis are joined in step (3) gained filtrate; mix homogeneously; be concentrated into relative density 1.10-1.20(45 DEG C) thick paste (be preferably concentrated into the thick paste of relative density 1.12-1.18; be more preferably the thick paste being concentrated into relative density 1.15); add simple syrup, mixing, makes uniform granule; sterile packaged, every parcel 6g.

7. the preparation method of the sensible medicament of calming the nerves of improvement according to claim 6 retarded patient intelligence, is characterized in that: the consumption of the preferred simple syrup of step (4) is the 10%-20% of thick paste quality, and the consumption being more preferably simple syrup is 15% of thick paste quality.

8., according to the sensible medicament of calming the nerves of the arbitrary described improvement retarded patient intelligence of claim 1-3, it is characterized in that, this sensible medicament of calming the nerves is made pharmaceutically acceptable pill, and preparation method is:

(1) Haematitum is placed in mortar, grind into powder, is placed in glass container, add water stirring, inclines and get suspension, the coarse powder of sinking as above method repeatable operation 2-3 time, discard impurity, merge suspension, leave standstill 4-6 hour, the clear water on upper strata of inclining, get precipitation to dry, porphyrize, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(2) Radix Angelicae Sinensis, Radix Aconiti Coreani and Radix Polygalae are cut into the sheet of 0.3-0.5mm, be placed in non iron container, add the sorghum wine (sorghum wine of preferred 43-47o is more preferably the sorghum wine of 45o) of 40-50o, soak 2-4 hour, put into and steam container water proof heating 2-3 hour;

(3) Poria cum Radix Pini, Fructus Galangae, Fructus Viticis and Semen Astragali Complanati are placed in glass container, soak and (preferably soak 3.5-4.5 hour in 3-5 hour, be more preferably immersion 4 hours), be placed in marmite, add step (2) gains, Fructus Lycii, Ramulus Cinnamomi, Fructus Alpiniae Oxyphyllae, Cortex Albiziae, Rhizoma Acori Graminei and Folium Nelumbinis, decoct with water twice, each decoction (preferably decocts 33-37 minute in 30-40 minute at every turn, be more preferably each decoction 35 minutes), merging filtrate;

(4) step (1) gained fine powder and artificial Calculus Bovis are joined in step (3) gained filtrate, mix homogeneously, be concentrated into relative density 1.10-1.20(45 DEG C) thick paste (be preferably concentrated into the thick paste of relative density 1.12-1.18, be more preferably the thick paste being concentrated into relative density 1.15), make the namely loose soft material that hands pinches agglomerating pressure, dry, pulverize, obtain medicated powder;

(5) Mel is placed in pot, temper with slow fire, endure to thick Deng Mel, add the medicated powder of step (4) gained, fully mix into ointment thoroughly, make that color and luster is consistent, evenly (preferred diameter is 3-5mm to size, being more preferably diameter is 4mm) elementary finished product ball, be placed in baking oven and slowly dry, take out, In Shadely naturally to dry in the shade, sterile packaged.

9. the preparation method of the sensible medicament of calming the nerves of improvement according to claim 8 retarded patient intelligence, is characterized in that: step (5) preferably Mel consumption is the 10%-20% of medicated powder quality, be more preferably that Mel consumption is medicated powder quality 15%.

10., according to the sensible medicament of calming the nerves of the arbitrary described improvement retarded patient intelligence of claim 1-3, it is characterized in that, this sensible medicament of calming the nerves is made pharmaceutically acceptable tablet, and preparation method is:

(1) Haematitum is placed in mortar, grind into powder, is placed in glass container, add water stirring, inclines and get suspension, the coarse powder of sinking as above method repeatable operation 2-3 time, discard impurity, merge suspension, leave standstill 4-6 hour, the clear water on upper strata of inclining, get precipitation to dry, porphyrize, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(2) Radix Angelicae Sinensis, Radix Aconiti Coreani and Radix Polygalae are cut into the sheet of 0.3-0.5mm, be placed in non iron container, add the sorghum wine (sorghum wine of preferred 43-47o is more preferably the sorghum wine of 45o) of 40-50o, soak 2-4 hour, put into and steam container water proof heating 2-3 hour;

(3) Poria cum Radix Pini, Fructus Galangae, Fructus Viticis and Semen Astragali Complanati are placed in glass container, soak and (preferably soak 3.5-4.5 hour in 3-5 hour, be more preferably immersion 4 hours), be placed in marmite, add step (2) gains, Fructus Lycii, Ramulus Cinnamomi, Fructus Alpiniae Oxyphyllae, Cortex Albiziae, Rhizoma Acori Graminei and Folium Nelumbinis, decoct with water twice, each decoction (preferably decocts 33-37 minute in 30-40 minute at every turn, be more preferably each decoction 35 minutes), merging filtrate;

(4) step (1) gained fine powder and artificial Calculus Bovis are joined in step (3) gained filtrate; mix homogeneously; be concentrated into relative density 1.10-1.20(45 DEG C) thick paste (be preferably concentrated into the thick paste of relative density 1.12-1.18; be more preferably the thick paste being concentrated into relative density 1.15); make the namely loose soft material that hands pinches agglomerating pressure; with fashion of extrusion by 18-26 eye mesh screen (preferred 20-24 eye mesh screen excessively; be more preferably 22 eye mesh screens); make single-size; dry; be pressed into lamellar, sugar coating.