A kind of zinc yellow extract oral liquid and preparation technology of brain-nourishing intelligence-benefiting
Technical field
The invention belongs to the Chinese medicine health care product field, particularly a kind of zinc yellow extract oral liquid and preparation technology of brain-nourishing intelligence-benefiting.
Background technology
Zinc is the important composition composition of many enzymes in body, has enhancing development, improves the effect such as the sense of taste.During shortage, growth retardation, impotence generandi, wound are difficult for healing, body is weak, also conjunctivitis, stomatitis, glossitis, anorexia, chronic diarrhea, gustatory anesthesia and nervous symptoms etc. can occur.Zinc is particularly important to upgrowth and development of children.Zinc gluconate is zinc supplement, is mainly used in baby and old age, the growth retardation that the gravid woman causes because of zinc deficiency, malnutrition, apositia, the diseases such as recurrent oral ulceration.Main Ingredients and Appearance as Zinc Gluuconate Oral Solution, zinc gluconate and Rhizoma Polygonati also have other compatibility, as " compound formulation for the treatment of nutritional iron deficiency anemia " CN94118569.9, it mainly is comprised of the Six-element Chinese drug-treated group such as Rhizoma Polygonati, Fructus Crataegi, Radix Salviae Miltiorrhizae, Rhizoma Atractylodis, Semen Lablab Album, Fructus Schisandrae Chinensis and zinc gluconate etc., and it has the spleen QI invigorating that continues, hereby sun is enriched blood and directly supplemented the necessary ferrum of human body, the effect of zinc element; " a kind of compound recipe and preparation method and application with kidney invigorating and Yang strengthening function " CN200810019371.9 and for example, by the effective compound recipe that forms of spice such as Arillus Longan, Rhizoma Polygonati, Concha Ostreae, Sanguis cervi powder, Fructus Alpiniae Oxyphyllae, Fructus Lycii, Fructus Rubi, Semen Sesami Nigrum, Semen Euryales, Rhizoma Dioscoreae, Cortex Cinnamomi, zinc gluconate, can bone and muscle strengthening, building body, cerebral function improvement, eliminate lethargy, the effects such as hypomnesis.
Summary of the invention
The zinc yellow extract oral liquid and the preparation technology that the purpose of this invention is to provide a kind of resisting fatigue, hypermnesis, calm the nerves.
One of technical solution of the present invention is:
It is to be made by the raw material that comprises following weight parts: 45-55 parts of zinc gluconate, and 12-18 parts of Rhizoma Polygonatis, 12-16 parts of Fructus Lycii, 12-16 parts of Radix Polygalaes, 12-16 parts of Fructus Jujubaes, 12-16 parts of Semen Juglandis,
Stone12-16 parts of Rhizoma Acori Gramineis, 25-35 parts of Concha Haliotidis, 12-16 parts of Poria cum Radix Pinis, 5-9 parts, Herba Albiziae, 8-12 parts of Rhizoma Dioscoreaes, 4-6 parts, Radix Glycyrrhizae, 90-110 parts of citric acids, 90-110 parts of xanthan gum, 450-500 parts of white sugars, 1000-1200 parts, water.
Two of technical solution of the present invention is:
First with Rhizoma Polygonati, Fructus Lycii, Radix Polygalae, Fructus Jujubae, Semen Juglandis, Rhizoma Acori Graminei, Concha Haliotidis, Poria cum Radix Pini, Herba Albiziae, Rhizoma Dioscoreae, Radix Glycyrrhizae, after adding water and respectively decocting secondary, the rear filtration of removing slag, after concentrated, let cool, add ethanol, stir evenly and placed 18-36 hours, after ethanol to be recycled, filtrate is concentrated into the extractum shape, and separately with zinc gluconate, white sugar is dissolved in water, is added in extractum, stir evenly to dissolving fully, dilute with water, filter, then add water; Cold preservation, filter, and is packaged in 10 milliliters of bottles and seals; Sterilizing and get final product with boiling water.
Rhizoma Polygonati supplementing QI and nourishing YIN in side of the present invention, tonify without causing stagnation, clothes can promote brain function to recover for a long time; Semen Juglandis, Rhizoma Acori Graminei brain-strengthening power, beneficial intelligence; The Fructus Jujubae invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind; Radix Polygalae, Herba Albiziae, Poria cum Radix Pini's mind tranquilizing and the heart calming; Fructus Lycii, nutritious Chinese yam Liver and kidney, spleen invigorating benefit essence; The liver heat removing of Concha Haliotidis suppressing the hyperactive liver; Join Radix Glycyrrhizae and middle nourishing the stomach.All medicines share, and play altogether the merit of brain-nourishing intelligence-benefiting, nourishing QI and blood, mind tranquilizing and the heart calming.
In side, zinc gluconate is zinc supplement, is mainly used in the growth retardation that children's causes because of zinc deficiency, the diseases such as malnutrition.
On probation through 282 children, result is as follows.
1, basic condition: amount to 282 children, mostly substantially meet heart syndrome of spleen-deficiency scope described in " the dialectical reference standard of Chinese medicine deficiency-syndrome " (in May, 1986 revision), but symptom is all lighter.All medication persons are divided into two groups at random, oral liquid group (embodiment 1) 167 examples, contrast (sucrose solution) group 115 examples.
2, Therapeutic Method: oral liquid group, matched group equal every day is oral twice, each 20ml.Be 1 month the course for the treatment of.
3, the curative effect determinate standard deficiency of both the heart and spleen has the deficient symptoms such as lassitude, malaise, bradykinesia, dreaminess, forgetful, lack of appetite mostly, on probation according to the child after related symptoms alleviate degree and formulate curative effect determinate standard.
1. produce effects: symptom, sign are obviously improved.
2. effective: symptom, sign all take a favorable turn.
3. invalid: symptom, sign are without obviously improving or adding severe one.
4, statistical method adopts t check and ⅹ
2Check.
5, result
Two groups of medication person's Clinical efficacy comparisons, produce effects 58 examples in oral liquid group 167 examples, effective 93 examples, invalid 16 examples, total effective rate is 90.4%; Produce effects 0 example in matched group 115 examples, effective 8 examples, invalid 107 examples, total effective rate 7.0%.Show oral liquid group total effective rate greater than matched group by above data, through t check, two groups of difference tool statistical significances (P<0.001).
The specific embodiment
The present invention can specifically implement by the technology that illustrates in summary of the invention, can conduct further description the present invention by the following examples, yet scope of the present invention is not limited to following embodiment.
Embodiment 1:
Get 50 parts of zinc gluconate, 15 parts of Rhizoma Polygonatis, 15 parts of Fructus Lycii, 15 parts of Radix Polygalaes, 15 parts of Fructus Jujubaes, 15 parts of Semen Juglandis,
Stone15 parts of Rhizoma Acori Gramineis, 30 parts of Concha Haliotidis, 15 parts of Poria cum Radix Pinis, 7 parts, Herba Albiziae, 10 parts of Rhizoma Dioscoreaes, 5 parts, Radix Glycyrrhizae, 100 parts of citric acids, 100 parts of xanthan gum, 500 parts of white sugars, 1000 parts, water.
Preparation technology: first with Rhizoma Polygonati, Fructus Lycii, Radix Polygalae, Fructus Jujubae, Semen Juglandis, Rhizoma Acori Graminei, Concha Haliotidis, Poria cum Radix Pini, Herba Albiziae, Rhizoma Dioscoreae, Radix Glycyrrhizae, after adding water and respectively decocting secondary, the rear filtration of removing slag, after concentrated, let cool, add ethanol, stir evenly and placed 18-36 hours, after ethanol to be recycled, filtrate is concentrated into the extractum shape, and separately with zinc gluconate, white sugar is dissolved in water, is added in extractum, stir evenly to dissolving fully, dilute with water, filter, then add water; Cold preservation, filter, and is packaged in 10 milliliters of bottles and seals; Sterilizing and get final product with boiling water.
Embodiment 2:
55 parts of zinc gluconate, 12 parts of Rhizoma Polygonatis, 16 parts of Fructus Lycii, 12 parts of Radix Polygalaes, 16 parts of Fructus Jujubaes, 12 parts of Semen Juglandis,
Stone16 parts of Rhizoma Acori Gramineis, 25 parts of Concha Haliotidis, 16 parts of Poria cum Radix Pinis, 5 parts, Herba Albiziae, 12 parts of Rhizoma Dioscoreaes, 4 parts, Radix Glycyrrhizae, 110 parts of citric acids, 90 parts of xanthan gum, 500 parts of white sugars, 1000 parts, water.
Preparation method such as embodiment 1.
Embodiment 3:
45 parts of zinc gluconate, 18 parts of Rhizoma Polygonatis, 12 parts of Fructus Lycii, 16 parts of Radix Polygalaes, 12 parts of Fructus Jujubaes, 16 parts of Semen Juglandis,
Stone12 parts of Rhizoma Acori Gramineis, 35 parts of Concha Haliotidis, 12 parts of Poria cum Radix Pinis, 9 parts, Herba Albiziae, 8 parts of Rhizoma Dioscoreaes, 6 parts, Radix Glycyrrhizae, 90 parts of citric acids, 110 parts of xanthan gum, 450 parts of white sugars, 1200 parts, water.
Preparation method such as embodiment 1.
Embodiment 4:
48 parts of zinc gluconate, 16 parts of Rhizoma Polygonatis, 14 parts of Fructus Lycii, 14 parts of Radix Polygalaes, 14 parts of Fructus Jujubaes, 14 parts of Semen Juglandis,
Stone14 parts of Rhizoma Acori Gramineis, 32 parts of Concha Haliotidis, 14 parts of Poria cum Radix Pinis, 8 parts, Herba Albiziae, 9 parts of Rhizoma Dioscoreaes, 5 parts, Radix Glycyrrhizae, 95 parts of citric acids, 95 parts of xanthan gum, 480 parts of white sugars, 1100 parts, water.
Preparation method such as embodiment 1.