CN104547210B - A kind of tcm product prevented and cure Car-sickness - Google Patents

Abstract

The invention discloses a kind of tcm product prevented and cure Car-sickness, 1) anise, the cordate houttuynia of 15 parts by weight, the mountain chrysanthemum of 12 parts by weight, the Momordica grosvenori of 2 parts by weight of 25 parts by weight are taken, smashes, is put into pressure pan, the pure water of identical weight is added, 4kgf/cm is forced into², make its pressure uniform, and 10 15min are kept, recover normal pressure, filtering obtains extract solution；2) ultrasonication：By step 1) obtain extract solution, the 10min of ultrasonication 5,40 50 DEG C of operative temperature, power is 300W；3) material allocation：By step 2) filtering of obtained solution, filtrate and pure water are according to 1:2 weight, than mixing, is 35 with citric acid adjustment pH；4) step 3) after obtained solution filtering through UHT instantaneous sterilizations, sterile filling obtains the tcm product that a kind of composition is simple, effect significantly prevents and cure Car-sickness.

Description

A kind of tcm product prevented and cure Car-sickness

Technical field

The present invention relates to technical field of traditional Chinese medicines, more particularly to a kind of tcm product prevented and cure Car-sickness.

Background technology

Carsickness, English name motion sickness also cry motion sickness, train sickness, pelagism, air-sickness, universe cinetosis Disease, when being automobile, steamer or airplane motion it is produced jolt, wave or rotate etc. it is any type of accelerate, stimulate people The vestibular nerve of body and the disease occurred.Patient feels epigastric discomfort at the beginning, after having nausea, pale complexion, cold sweat, soon has Dizziness, mental depression, salivary secretion increase and vomitted.This disease often by bus, navigation, flight and other run several minutes to several small When after occur.Epigastric discomfort is felt at the beginning, after having nausea, pale complexion, cold sweat, soon there is dizziness, mental depression, saliva point Secrete and increase and vomit.Severe patient can have drop in blood pressure, breathing deep and slow, nystagmus.Serious vomiting causes dehydration and electrolyte It is disorderly.The general dozens of minutes after out of service or deceleration of symptom and disappearance or mitigation in a few houres.After repeatedly morbidity, symptom It can instead mitigate, not occur even.

The symptom of motion sickness often gradually develops, and from having a stomach upset nausea, is in a cold sweat, finally to vomiting.Motion sickness It is preventable, although everyone constitution is different with sensitivity, some people are particularly sensitive, but has method help These easy carsick people avoid the occurrence of the situation of motion sickness.(1) strengthen taking exercises, strengthen vestibular organ tolerance.Cinetosis The multiple vestibular organ of being born in of disease is than more sensitive people.Therefore, it is usually to note taking exercises more, do rotary head more, bend over to turn round and under The action such as crouching, to increase the tolerance of vestibular organ.(2) stuff oneself, fatigue, sleep insufficiency, air it is dirty, nervous and The special odor such as gasoline and oil smoke may all promote generation and the exacerbation of symptoms of motion sickness, therefore avoid these undesirable elements. (3) special vestibular exercise.Can be such as repeated multiple times to train by ship, by bus by rehabilitation training prevention of motion sickness, to improve vestibular Adaptability of the organ to irregular movement.In addition, some activities can often be participated in by fearing the people of carsickness, especially contribute to The sports items of position of human body balance are adjusted, such as swing, slide, horizontal bar ＆ parallel bars, sports events of rolling on pad can improve vestibular apparatus The adaptability of official.(4) ride, by ship when should try one's best limitation head movement, can by head rest on chair with back it is fixed, with reduction The stimulation of acceleration, particularly rotates sexual stimulus.If being possible to, prostration as far as possible.(5) bad visual stimulus is avoided.By bus When it is few toward watching outside window, by bus, by ship when reading be easier to induce motion sickness, therefore close the eyes for rest and can reduce the hair of motion sickness It is raw.

It can take happy containing buccal tablet etc. before by bus, with prevention of motion sickness.Cholinolytic class medicine has suppression to make to cerebral cortex With dizziness and vomiting can be prevented.Such as Chinese patent CN101766559B, disclose it is a kind of have mosquito repellent, relax the muscles and stimulate the blood circulation, carsickness-proof It is 3-10 parts of camphor of dissolving, vitamin E 0.1-2 in cruel 100 parts of phthalic acid diformazan Deng the multifunctional skin-protection oil of effect Part, 3-5 parts of salicylic acid first vinegar, 5-10 parts of eucalyptus oil, 3 parts of caryophyllus oil, 3-15 parts of menthol, appropriate essence.The traditional Chinese medical science is of extensive knowledge and profound scholarship, Developing the tcm product prevented and cure Car-sickness has good market prospects.

The content of the invention

The technical problem to be solved in the present invention is for the existing product composition that prevents and cure Car-sickness is complicated or effect is unstable etc. It is not enough to be formulated the tcm product that simple, effect significantly prevents and cure Car-sickness there is provided a kind of.

The present invention is achieved through the following technical solutions：

A kind of tcm product prevented and cure Car-sickness, is prepared by the following preparation method：

1) anise, the cordate houttuynia of 15 parts by weight, the mountain chrysanthemum of 12 parts by weight, the Momordica grosvenori of 2 parts by weight of 25 parts by weight are taken, Smash, be put into pressure pan, add the pure water of identical weight, be forced into 4kgf/cm², make its pressure uniform, and keep 10- 15min, recovers normal pressure, and filtering obtains extract solution；

2) ultrasonication：By step 1) obtain extract solution, ultrasonication 5-10min, 40-50 DEG C of operative temperature, work( Rate is 300W；

3) material allocation：By step 2) filtering of obtained solution, filtrate and pure water are according to 1:2 weight is used than mixing Citric acid adjustment pH is 3-5；

4) step 3) obtain solution filtering after through UHT instantaneous sterilizations, sterile filling.

Anise of the present invention, cordate houttuynia, mountain chrysanthemum and Momordica grosvenori, are fresh or drying.

The present invention uses plant for raw material completely, wherein：

Anistree (scientific name：Illicium verum), also known as Chinese anise, aniseed and anise are that Chinese anise mesh is anistree A kind of plant of section's Illicium, its dry fruit is one of Chinese dishes and the flavoring of south east asia culinary art, and star aniseed powder refers to Dried anistree crush is obtained.Anistree fruit contains containing volatile oil, fat oil, protein, resin etc., and extract is fennel Containing fennel oil 1.7-2.7% in oil, wherein seed, the star anise oil content of dry fruit and cured leaf is respectively 12-13%, 1.6- 1.8%.The main component of fennel oil is anisole (Anethole), anisaldehyde (Anisaldehyde) and fenchone (Anisylacetone), safrole (Safrole), phellandrene etc..Fennel oil energy stimulating gastrointestinal neural blood vessel, promotes digestive juice Secretion, increases gastrointestinal peristalsis, there is stomach invigorating, promoting the circulation of qi, helps to alleviate spasm, mitigates pain；Phellandrene can promote marrow Cell maturation is simultaneously released into peripheral blood, plays the role of obvious increasing leukocyte, mainly raises neutrophil leucocyte, can be used for Leukopenia.

Cordate houttuynia, English name HERBA HOUTTUYNIAE are the herbal medicine that Chinese Pharmacopoeia is included, and herbal medicine source is saururus chinensis Section's plant heartleaf houttuynia (Classification system：Houttuynia cordata Thunb.) dry aerial parts.The luxuriant flower spike of summer cauline leaf Tapped when many, remove impurity, dry.Herbal medicine character：Stem is in oblate cylindricality, distortion, long 20-35cm, diameter 0.2-0.3cm；Table Face brown color, tool vertical rib several, section is obvious, has remaining fibrous root on the section of bottom；Matter is crisp, frangibility.Leaf alternate, blade convolution wrinkle Contracting, in heart, long 3-5cm, wide 3-4.5cm after flattening；Tip is tapering, full edge；Upper surface darker yellow green is to burgundy, lower surface Celadon or taupe brown；Petiole is elongated, and base portion and stipule symphysis are into sheath shape.Spike basidixed, yellowish-brown.Rub broken bear the odor of fish with the hands Taste.Cordate houttuynia is pungent, cold, return lung warp.Can clearing heat and detoxicating, detumescence treatment sore, promoting urination and removing dampness, clearing away heat to cure dysentery, stomach strengthening and digestion promoting, use Lung carbuncle, sore swollen toxin, hemorrhoidal hemorrhage, retention of heat in the spleen and stomach for controlling real heat, heat toxin, damp evil, disease heat to suffer from etc..Modern pharmacology tests table Bright, this product has the effect such as antibacterial, antiviral, raising immunity of organisms, diuresis.

Mountain chrysanthemum, also known as hill chrysanthemum, LUBIANJU, FLOS CHRYSANTHEMI INDICI, the bitter heart of a lotus seed etc., it is composite family Chrysanthemum herbaceos perennial, distribution In northeast, North China, Central China, south China and southwestern each province, hillside, wilderness, roadside are born in.It, which is spent, has splendid medicinal health effect It is a kind of healthy tea with high consumption value.Chrysanthemum indicum is the capitulum of feverfew mother chrysanthemum.It is cool in nature, bitter, Pungent, return lung liver two passes through, wind and heat dispersing, subdhing swelling and detoxicating, treatment anemopyretic cold, pneumonia, the disease chrysanthemum indicum such as hypertension, aphtha, erysipelas It is distributed widely in the ground such as China northeast, North China, northwest, East China, southwest, wild resource enriches.Mountain chrysanthemum is containing in alantol, chrysanthemum indicum The various active composition such as ester, amino acid, trace element.Its aqueous extract has obvious protective function to cardiovascular system, can improve Cardiac output, increases myocardial oxygen consumption, protects the normal physiological function of ischemic myocardium.Mountain chrysanthemum water extract and steam distillation The blue-green volatile oil of extraction to various pathogens, virus have killing or inhibitory activity, water extract to staphylococcus aureus, The inhibitory activity of shigella dysenteriae, EHEC, typhoid bacillus etc. is better than volatile oil；And have anti-inflammatory, anti-oxidant, analgesic activities. With clearing heat and detoxicating, detumescence.To staphylococcus aureus, corynebacterium diphtheriae, streptococcus, Pseudomonas aeruginosa, puncture Shigella, influenza disease Poison, there is inhibitory action.

Momordica grosvenori, also known as LAHANGUO, balloonvine heartseed herb, Semen Momordicae, invaluable, arhat table, naked tortoise bar, mainly originate in Guangxi Zhuang Yongfu county Longjiang township of Guilin City of autonomous region of race and the mountain area of hundred Shou Deng towns and Lingui, wherein Yongfu county are the township of Momordica grosvenori, arhat Fruit is the rare local and special products in Guilin.Momordica grosvenori, is akala herbaceous plant, and its stem tuber is loose, and perennation is the distinctive treasure of China Your cucurbitaceous plant, have the title of the good fruit of good medicine.Momordica grosvenori is described as " angle fruit " by people, and fruits nutrition value is very high, containing rich Rich vitamin C (containing 400-500 milligrams in every 100 grams of fresh fruits) and glucoside, fructose, glucose, protein, lipid etc..Work( It can cure mainly：Clearing lung-heat ease constipation, control pertussis, phlegm-fire cough, the dry constipation of blood.①《The south of the Five Ridges is gathered medicinal herbs record》：" reason phlegm-fire cough, and pig essence Meat decoct soup takes it."②《Guangxi Chinese medicinal herbal》：" cough-relieving heat-clearing, cool blood ease constipation.Control cough, the dry stomach energy constipation of blood etc.." its purposes is wide General, enjoy a good market both at home and abroad market, enjoys a very good reputation in the international market.

The present invention is using anise, cordate houttuynia, the prescription of mountain chrysanthemum, by stimulating nerve endings, paralysis peripheral vestibular impression Device, so as to mitigate the stimulation produced during the movement of the vehicles such as vehicle, these stimulations make the capsule marble of vestibular utricle and sacculus Cell produces deformation electric discharge, transmits and perceives to maincenter, the generation of these vestibular electric signals, is delivered in certain limit and time People will not produce adverse reaction, reach the purpose prevented and cure Car-sickness, be the suitable patient of diabetes in order to adjust mouthfeel using Momordica grosvenori Person takes.

Compared with prior art, the present invention has advantages below：

The compositions such as polysaccharide, alkaloid in the 1st, present invention use HIGH PRESSURE TREATMENT raw material, raw material are decomposed completely, dissolution so that Nutrition is more easily absorbed.

2nd, the present invention then uses ultrasonic wave extraction again after using HIGH PRESSURE TREATMENT raw material, and what ultrasonic wave extraction was utilized is Strong mechanical shearing effect, can promote the dissolution of nutritional ingredient in raw material.

Embodiment

With specific embodiment, the invention will be further described below, but the invention is not limited in these embodiments.

Embodiment 1

A kind of tcm product prevented and cure Car-sickness, is prepared by the following preparation method：

1) 25kg anises, 15kg cordate houttuynias, 12kg mountain chrysanthemums, 2kg Momordica grosvenoris are taken, smashes, is put into pressure pan, phase is added With the pure water of weight, 4kgf/cm is forced into², make its pressure uniform, and 10min is kept, recover normal pressure, filtering is extracted Liquid；

2) ultrasonication：By step 1) obtain extract solution, ultrasonication 5min, 50 DEG C of operative temperature, power is 300W；

3) material allocation：By step 2) filtering of obtained solution, filtrate and pure water are according to 1:2 weight is used than mixing Citric acid adjustment pH is 3-5；

4) step 3) obtain solution filtering after through UHT instantaneous sterilizations, sterile filling.

Embodiment 2

A kind of tcm product prevented and cure Car-sickness, is prepared by the following preparation method：

1) 25kg anises, 15kg cordate houttuynias, 12kg mountain chrysanthemums, 2kg Momordica grosvenoris are taken, smashes, is put into pressure pan, phase is added With the pure water of weight, 4kgf/cm is forced into², make its pressure uniform, and 15min is kept, recover normal pressure, filtering is extracted Liquid；

2) ultrasonication：By step 1) obtain extract solution, ultrasonication 8min, 45 DEG C of operative temperature, power is 300W；

3) material allocation：By step 2) filtering of obtained solution, filtrate and pure water are according to 1:2 weight is used than mixing Citric acid adjustment pH is 3-5；

4) step 3) obtain solution filtering after through UHT instantaneous sterilizations, sterile filling.

Embodiment 3

A kind of tcm product prevented and cure Car-sickness, is prepared by the following preparation method：

1) 25kg anises, 15kg cordate houttuynias, 12kg mountain chrysanthemums, 2kg Momordica grosvenoris are taken, smashes, is put into pressure pan, phase is added With the pure water of weight, 4kgf/cm is forced into², make its pressure uniform, and 12min is kept, recover normal pressure, filtering is extracted Liquid；

2) ultrasonication：By step 1) obtain extract solution, ultrasonication 10min, 40 DEG C of operative temperature, power is 300W；

3) material allocation：By step 2) filtering of obtained solution, filtrate and pure water are according to 1:2 weight is used than mixing Citric acid adjustment pH is 3-5；

4) step 3) obtain solution filtering after through UHT instantaneous sterilizations, sterile filling.

Experimental example：Clinical test

1st, applied code is selected

It is all by bus, by ship or aircraft has carsick phenomenon person alternatively standard；

2nd, diagnostic criteria

It is all feel dizzy by bus, by ship or during aircraft, have a stomach upset, Nausea and vomiting, body are felt bad or other uncomfortable persons It is diagnosed as carsickness；

3rd, evaluation criteria

Symptom resolution：Using being ridden in an automobile after the present invention, the sensation of aircraft, ship without any discomfort, all are as before；

Symptom mitigation：Carsick phenomenon mitigates or substantially mitigated；

It is invalid：Carsick phenomenon is without any improvement, using preceding with using rear indifference；

4th, therapeutic scheme

Trip drinks embodiment 3, each 250mL for 30-60 minute by bus, before ship or aircraft, and sets control group progress effect Contrast, control group takes hydrobromic acid Anisodus luridus；

5th, result

The embodiment of the present invention 3 is better than control group.

Claims (1)

1. a kind of tcm product prevented and cure Car-sickness, it is characterised in that be prepared by the following preparation method：

1) anise, the cordate houttuynia of 15 parts by weight, the mountain chrysanthemum of 12 parts by weight, the Momordica grosvenori of 2 parts by weight of 25 parts by weight are taken, is beaten It is broken, it is put into pressure pan, adds the pure water of identical weight, be forced into 4kgf/cm², make its pressure uniform, and keep 10- 15min, recovers normal pressure, and filtering obtains extract solution；

2) ultrasonication：By step 1) obtain extract solution, ultrasonication 5-10min, 40-50 DEG C of operative temperature, power is 300W；

3) material allocation：By step 2) filtering of obtained solution, filtrate and pure water are according to 1:2 weight uses lemon than mixing Acid adjustment pH is 3-5；

4) step 3) obtain solution filtering after through UHT instantaneous sterilizations, sterile filling.