CN104547091B - It is a kind of to treat medicine of Osteoarthritis and preparation method thereof - Google Patents

Abstract

The invention discloses a kind of medicine for treating Osteoarthritis, the medicine is made up of the red sage root, giant knotweed, caulis lonicerae, the windproof, root bark of tree peony, radix scutellariae, the root of Chinese clematis, bark of ash, barrenwort and auxiliary material.The present invention has the effect of promoting blood circulation, dispelling wind and eliminating dampness, clearing away heat to and alleviating pain.Osteoarthritis for being mainly used in caused by liver and kidney deficiency, rheumatism retardance and blood stasis and causing etc., symptoms include bone joint pain, bone weight is difficult to be lifted, arthroncus, textured bone.The curative effect of medication being made significantly, has no toxic side effect.

Description

It is a kind of to treat medicine of Osteoarthritis and preparation method thereof

Technical field

The present invention relates to a kind of medicine for treating Osteoarthritis and preparation method thereof, belong to the field of medicine technology.

Background technology

Osteoarthritis is a kind of chronic progressive osteoarthropathy, is more common in the elderly.It is broken with chronic progressive cartilage Bad and new bone formation is the degenerative disease of main feature.Definition of the American society of rheumatism to Osteoarthritis be：One group has Different pathogeny but there are similar physiology, morphology and the disease of clinical manifestation.Cartilage lesion not only occurs for the disease, also tires out And whole joint, including subchondral bone, ligament, capsular ligament, synovial membrane and periarticular muscles, final cartilage degeneration, fiber Change, be broken, ulcer and whole articular surface are damaged.The lighter influences work and quality of life；Severe patient can cause people maimed, lose work Ability, life is rough takes care of oneself.With population increasingly aging, increasing people suffers from Osteoarthritis.

With population increasingly aging, increasing people suffers from Osteoarthritis.According to epidemiology survey China 60 years old Above crowd's knee osteoarthritis illness rate is up to 49%.But this sick complex genesis, cured so far without highly effective medicine, Medicine workable for the osteoarthritis diagnosis and treatment guide formulated according to rheumatology branch of Chinese Medical Association, only for control symptom NSAIDs and improve Glucosamine Sulphate, diacerein, sodium hyaluronate injection etc. of the state of an illness, do not reach much The purpose of effective symptom management.Modern medicine thinks that osteoarthritis is that one kind is sexually revised and articular cartilage side with articular cartilage Edge osteoproliferation, causes arthralgia, and swelling is stiff, the chornic arthritis of the performance such as deformity and dysfunction.Its definite hair Interpretation of the cause, onset and process of an illness system is not yet illustrated, may be with aging, and wound, inflammation is fat, dysbolism, the correlation such as inherent cause.In recent years, develop With use articular cartilage protectiveness medicine, such as diacerein, Glucosamine Sulphate delays the pathologic process of osteoarthritis；Or Person prevents and treats osteoarthritis with cytokine mAbs body or gene, although have a certain curative effect, but drug price is sufficiently expensive and secondary makees With big.

At present, clinically Osteoarthritis treatment is mainly drug therapy and operative treatment.Medicine is big used in drug therapy Part is analgestic, antipyretic-antalgic agent, cortin, hyaluronic acid and aminoglucose carbohydrate supplementation material, and such preparation is long-term Drug resistance and toxic side effect can be produced by taking.Operative treatment can give the heavy psychology of patient and economic pressures burden.But it is so far Only, heumatism or knee numbness are specially controlled without a kind of good Chinese patent drug（Osteoarthritis）, although there are some Chinese patent drugs to can be used for heumatism, such as The safe capsule of the multiple recovering particles of Gulingtongbi Pill, day numbness, gram numbness bone, Sialon rheumatism soft capsule, Bitongping for pains of numbness capsule, Yitongshu oral liquid, The red piece of zhuanggushenjin capsule, bone and kidney health oral liquid and the leaves of pulse plants.These preparation weak points：Containing the big medicine of toxic component, such as Vomiting nut, datura flower, monkshood, radix aconiti agrestis etc..In Singapore, even if prohibiting, Chinese patent drug is made of these medicines is not disabling, but not Taken suitable for long-time.And heumatism be chronic disease produce after want long-time medication treatment；Function specific aim is not strong, is not directed to The interpretation of the cause, onset and process of an illness, illness design prescription, its indication has rheumatism, rheumatoid, cervical spondylopathy, lumbar vertebra disease etc., be anodyne；Preparation Technique is not advanced, and effective ingredient is difficult to identify；Flavour of a drug number is more.

Therefore, a kind of effectively treatment Osteoarthritis is invented, the small medicine of toxic side effect has great importance.

The content of the invention

It is an object of the invention to provide a kind of medicine for treating Osteoarthritis and preparation method thereof.The medicine has The effect of promoting blood circulation, dispelling wind and eliminating dampness, clearing away heat to and alleviating pain.The Bones and joints for being mainly used in caused by liver and kidney deficiency, rheumatism retardance and blood stasis and causing Inflammation etc., symptoms include bone joint pain, bone weight is difficult to be lifted, arthroncus, textured bone.

To solve above technical problem, the present invention is realized using following technical scheme：

A kind of medicine for treating Osteoarthritis, is calculated in parts by weight, mainly by 5-20 parts of the red sage root, 5-20 parts of giant knotweed, 5-20 parts of caulis lonicerae, windproof 4-15 parts, 4-15 parts of the root bark of tree peony, 4-15 parts of radix scutellariae, 5-20 parts of the root of Chinese clematis, 4-15 parts of bark of ash, barrenwort 4-15 parts and auxiliary material are made.

In the medicine of aforementioned therapies Osteoarthritis, calculate in parts by weight, mainly by 9-15 parts of the red sage root, giant knotweed 9-15 Part, 9-15 parts of caulis lonicerae, windproof 6-12 parts, 6-12 parts of the root bark of tree peony, 6-12 parts of radix scutellariae, 9-15 parts of the root of Chinese clematis, 6-12 parts of bark of ash, excessive sheep 6-12 parts of the leaves of pulse plants and auxiliary material are made.

Specifically, in the medicine of aforementioned therapies Osteoarthritis, calculate in parts by weight, mainly by 12 parts of the red sage root, tiger 12 parts of cane, 12 parts of caulis lonicerae, windproof 9 parts, 9 parts of the root bark of tree peony, 9 parts of radix scutellariae, 12 parts of the root of Chinese clematis, 9 parts of bark of ash, 9 parts of barrenwort and auxiliary material It is made.

The preparation method of the medicine of aforementioned therapies Osteoarthritis, proportionally weigh the red sage root, giant knotweed, caulis lonicerae, it is windproof, Acceptable pharmaceutic adjuvant is combined in the root bark of tree peony, radix scutellariae, the root of Chinese clematis, bark of ash and barrenwort, with medicine, and according to routine Preparation method is processed, and corresponding pharmaceutical preparation is made.

In the preparation method of the medicine of aforementioned therapies Osteoarthritis, the red sage root, giant knotweed, caulis lonicerae, the windproof, root bark of tree peony, Huang are taken A kind of reed mentioned in ancient books, the root of Chinese clematis, bark of ash and barrenwort, add the 6-12 times of water measured, decoct 1-3 times, each 1-3 hours, and decocting liquid filtration, filtrate is dense Shorten clear cream into, be combined with acceptable pharmaceutic adjuvant in medicine, and be processed according to conventional preparation method, made Into corresponding pharmaceutical preparation.

In the preparation method of the medicine of aforementioned therapies Osteoarthritis, the red sage root, giant knotweed, caulis lonicerae, the windproof, root bark of tree peony, Huang are taken A kind of reed mentioned in ancient books, the root of Chinese clematis, bark of ash and barrenwort, add water to cook it is secondary, for the first time plus 10 times of amount decoctings are boiled 2 hours, second plus 8 times of amount water Decoct 1.5 hours, collecting decoction, filtration, relative density is 1.20~1.25 clear cream when filtrate is concentrated into 60 DEG C；With in medicine Acceptable pharmaceutic adjuvant is combined, and is processed according to conventional preparation method, and corresponding pharmaceutical preparation is made.

In the preparation method of the medicine of aforementioned therapies Osteoarthritis, the pharmaceutical preparation is granule, capsule or piece Agent.

In the preparation method of the medicine of aforementioned therapies Osteoarthritis, the granule is prepared：Take the red sage root, giant knotweed, Caulis lonicerae, the windproof, root bark of tree peony, radix scutellariae, the root of Chinese clematis, bark of ash and barrenwort, add water to cook secondary, the decoctings of 10 times of amounts of addition for the first time Boil 2 hours, add 8 times of amount decoctings to boil for the second time 1.5 hours, collecting decoction, decocting liquid filtration, relative density when filtrate is concentrated into 60 DEG C For 1.20~1.25 clear cream, the dextrin of the amount of being made 20%, 20% soluble starch and 0.15% sweetener is taken to add above-mentioned In clear cream, mix, particle is made with 75% ethanol, dries wet granular at 65 DEG C, whole grain, fill, produce.

In the preparation method of the medicine of aforementioned therapies Osteoarthritis, the capsule is prepared：Take the red sage root, giant knotweed, bear Winter rattan, the windproof, root bark of tree peony, radix scutellariae, the root of Chinese clematis, bark of ash and barrenwort, add water to cook secondary, the water that 10 times of addition for the first time is measured, decoct Boil 2 hours, the water of second plus 8 times amount is decocted 1.5 hours；Collecting decoction, decocting liquid filtration, filtrate is concentrated into relative at 60 DEG C Density is 1.20~1.25 clear cream, takes the dextrin of the amount of being made 10%, 10% soluble starch and 3% magnesium stearate to add State in clear cream, mix, with 75% alcohol granulation, dry wet granular at 65 DEG C, whole grain, fill, produce capsule.

In the preparation method of the medicine of aforementioned therapies Osteoarthritis, the tablet is prepared：Take the red sage root, giant knotweed, bear Winter rattan, the windproof, root bark of tree peony, radix scutellariae, the root of Chinese clematis, bark of ash and barrenwort, add water to cook secondary, the water that 10 times of addition for the first time is measured, decoct Boil 2 hours, the water of second plus 8 times amount is decocted 1.5 hours；Collecting decoction, decocting liquid filtration, filtrate is concentrated into relative at 60 DEG C Density is 1.20~1.25 clear cream, and clear cream adds the starch and 10% carboxymethyl cellulose of the amount of being made 20%, mixes, with 70% Alcohol granulation, tabletting is coated, produced.

Medicine of the present invention is by the red sage root, giant knotweed, caulis lonicerae, the windproof, root bark of tree peony, radix scutellariae, the root of Chinese clematis, bark of ash and barrenwort system Into.Wherein, the red sage root is that dicotyledon Lamiaceae Salvia belongs to perennial vertical herbage plant, and its root is a kind of Chinese medicine.Nature and flavor Hardship, is slightly cold.The thoughts of returning home, Liver Channel.The effect of having stasis-dispelling and pain-killing, invigorate blood circulation, relieving restlessness that clears away heart-fire.For irregular menstruation, closed dysmenorrhea, disease Lump in the abdomen is gathered, chest and abdomen shouting pain, hot numbness pain, sore swell and ache curative, dysphoria and insomnia；Hepatosplenomegaly, angina pectoris.Giant knotweed is polygonaceae plant giant knotweedPolygonum CuspidatumSieb. etZucc. dry rhizome and root.Mildly bitter flavor, cold nature.Return liver, courage, lung channel, Removing dampness through diuresis and removing jaundice, clearing heat and detoxicating, blood stasis removing analgesic is relieving cough and reducing sputum.For jaundice with damp-heat pathogen, stranguria with turbid discharge, under band, arthralgia pain due to rheumatism, carbuncle sore tumefacting virus, Scald, Amenorrhea, abdominal mass, instep plays damage, cough with lung heat.Caulis lonicerae also known as big climbing fig, bigcatkin willow rattan, Japanese Stephania Root, perennial half Evergreen voluble shrub, stem is hollow, the close raw pubescence of sprout.Leaf is to life；It is close by pubescence；Matter is crisp, frangibility, section yellow-white, It is hollow.Odorless, old branch mildly bitter flavor, spray is lightly seasoned.Impurity is removed, is cleaned, vexed profit, segment, is dried.With clearing heat and detoxicating, dispelling wind The curative effect of dredging collateral.Available for warm disease heating, sore and toxic, toxic-heat and blood stasis, beriberoid pyretic arthralgia.It is windproof, alias copper rue, Hui Yun, return grass, Hundred, hundred kinds.Herbaceos perennial, it is liked nice and cool weather, resisted cold, drought-resistant.Windproof Gen Kesheng is used.Pungent, sweet, property is micro- Temperature.Expel pathogenic wind from the body surface, effect of expel endogenous wind to relieve convulsion, only convulsion.The root bark of tree peony, also known as moutan bark.For ranunculaceae peony dry root skin.It is raw With or fry use.《Compendium of Materia Medica》：" nourishing Yin and falling fire, solution spot poison, throat, diuresis stasis.Descendant is specially to control mutually fire with amur cork tree, I do not know that the work(of the root bark of tree peony more wins.Red colored person's profit, the person of spending in vain mends, and people also seldom realizes, and preferably distinguishes it." modern study, contained paeonol and Glucosides constituents beyond it have antiinflammatory action；The methanolic extract of moutan bark has suppression Platelet；Paeonol has town The central inhibitory actions and antiatherosclerosis, diuresis, antiulcer etc. such as quiet, cooling, antipyretic, analgesia, spasmolysis are acted on.Radix scutellariae （Classification system：Scutellaria baicalensisGeorgi）, alias Radix Scutellariae, tsuchikane tea root are lamiaceae labiatae scutellarias Herbaceos perennial；The root of radix scutellariae is used as medicine, bitter, cold in nature, have heat-clearing and damp-drying drug, purging intense heat and detonicating, hemostasis, it is antiabortive the effects such as.It is main Control warm heat disease, the infection of the upper respiratory tract, cough with lung heat, neonatal jaundice caused by dampness-heat, pneumonia, dysentery, hemoptysis, hot eyes, fetal irritability, hypertension, The diseases such as carbuncle swells furuncle sore.The clinical antibiotic property of radix scutellariae is better than the coptis, and does not develop immunity to drugs.The root of Chinese clematis, its root and stem enter medical instrument There are wind-damp dispelling, degrading the channel, the bone that disappears to obstruct.Its new purposes is constantly found in modern clinic practice, such as treatment courage Calculus, calcaneal spur, talagia, cancer of the esophagus etc..Root is used as medicine, can wind-damp dispelling, diuresis, stimulate the menstrual flow, ease pain, control that chill is damp and hot, inclined head Pain, jaundice edema, the hard larynx of fish-bone, waist and knee legs and feet crymodynia.Fresh strain energy treating acute tonsillitis, sphagitis；Effect a radical cure filariasis, external application Control toothache.Bark of ash（Gentiana macrophyllaPall）, alias：Gentiana macrophylla, great Ye bark of ash, RADIX GENTIANAE MACROPHYLLAE.Pungent, hardship, It is flat.Return stomach, liver, gallbladder channel, wind-damp dispelling, clearing away damp-heat, stopping numbness pain.For muscle arteries and veins contraction, skeletal pain, afternoon tidal fever, infantile malnutrition Heating.Barrenwort, bitter and puckery flavor, suitable insomniac uses.Tonifying kidney and strengthening yang, dispelling wind and eliminating dampness.Control impotence not lift, inclined wind is unsuccessful, urine Drip is drenched, muscles and bones contraction is anxious, cough, after being ill glaucoma, toothache caused by fire of deficiency type, hemiplegia, waist-leg weakness, arthralgia pain due to rheumatism, four limbs are meciless.

Said medicine prescription is played promoting blood circulation, dispelling wind and eliminating dampness, effect of clearing away heat to and alleviating pain by the present invention altogether.For treating liver Deficiency of the kidney is empty, rheumatism retardance and blood stasis and osteoarthritis for causing etc., symptoms include bone joint pain, and bone weight is difficult to be lifted, arthroncus, and bone becomes Shape.And determined curative effect, toxic side effect is small.

The present invention has carried out substantial amounts of experimental study, is below the result of experimental study of the present invention：

Experimental example 1：Anti- regression to rabbit knee degenerative osteoarthropathy model acts on experiment

1. experimental animal selects 8~14 2.0~2.5kg of monthly age rabbit 28, male and female half and half are real by Guiyang College of Traditional Chinese Medicine Test animal housing's supply.Quality certification number SCXK（Guizhou Province）2002—0001.

2. medicine, dosage and medication：Granule of the present invention（Prepared according to the method for embodiment 1）.Control group medicine Thing zhuanggu guanjie pill, southern pharmaceutical factory produces [authentication code:(87) quasi- word K4-No. 03 of medicine is defended in Guangdong], 60g/bottle.Press body Surface area calculates dose (D2=D1 × R2/R1), grinds quantitatively feeding in feed.

3. animal packet：After buying rabbit nursing 7 days, animal is randomly divided into A, B, C, D4 group, every group 7.A groups (are controlled Treatment group):After modeling success, granule of the present invention is fed, is within 30 days 1 course for the treatment of, 2 course for the treatment of B groups (control group) is fed altogether:After modeling success, Zhuanggu guanjie pill is fed, is within 30 days 1 course for the treatment of, 2 courses for the treatment of is fed altogether.C groups (blank group):After modeling success, it is not administered, makees same with A, B group Phase blank control.D groups (normal group):Not modeling, concurrent control is made for 3 groups with A, B, C.

4. modeling method：3 groups of rabbit of A, B, C, which are taken its left back knee joint with plaster cast, to be stretched position and fixes, it is right after knee For own control side.D groups do not make any processing.4 groups of single cage raisings under the same conditions.By each group rabbit point when braking is full 6 weeks One is not put to death not at random, to observe modeling situation, is removed each group plaster fixing after modeling success.Plaster cast is noted in modeling Situation, bites if any loosening or being stung by rabbit, should retighten in time.

5. observation index：

（1）Gross examination of skeletal muscle：Treat after two courses for the treatment of, put to death each group rabbit, take rabbit knee sample to visually observe substantially feelings Condition.

（2）Tectology qualitative and quantitative analysis：Rabbit is put to death after modeling 6 weeks and after 2 courses for the treatment of of treatment respectively, and immediately Complete knee joint sample is cut, cartilage and bone tissue, capsular ligament, the synovial membrane of medial side of tibial plateau articular surface, 10% formal is taken Woods is fixed, and carries out conventional section, HE dyeing.Pathologic changes are observed under an optical microscope, and cartilage is changed with mircrometer gauge Situation carries out quantitative analysis.

6. result：

（1）Gross examination of skeletal muscle：Blank group (C), articular cartilage surface gloss density lowers, in faint yellow;Tactile softer, joint Surface imperfection, has spur to be formed；Capsular ligament, synovial membrane have to be thickened in various degree；Knuckle synovia is reduced, and has fibre around articular cartilage Dimension property adhesion, the visible a small amount of rotten to the corn point of articular cartilage surface.Control group (B), articular cartilage is in faint yellow, synovial membrane and capsular ligament increasing There is fibrous adherence around thickness, indivedual visible small rotten to the corn points of articular cartilage surface, articular cartilage.Treatment group (A), it is seen that Ge Bieguan Cartilage paler colour is saved, synovial membrane and capsular ligament are also thickened, but it is light compared with B, C group in degree, and the visible edge ossiculum having is gone to live in the household of one's in-laws on getting married, and is closed Save cartilage surface and change unobvious.Adhesion is slighter around articular cartilage, and cartilage has no substantially rotten to the corn point.Normal group (D), joint Cartilage surface is smooth, is creamy white, tough and flexible.

（2）Tectology qualitative analysis：

Under normal group (D), light microscope, articular cartilage can clearly be divided into top layer, layer of dividing a word with a hyphen at the end of a line, width and penetrate layer and cartilage base Matter calcified layer.The damp line of visible waveform between layer and calcified layer is penetrated in width.Blank group (C), articular cartilage surface is thinning, and cartilage is shallow Face fibrillation denaturation, cartilage surface is coarse, and sees crack and strip off, and cartilage cell's irregular arrangement, level is disorderly, normal cartilage 4 stratum boundaries limit is difficult identification.Visible cell is dispersed in hyperplasia in calcified layer, and the damp heading line off of majority section, subchondral bone shows as girder Bone thickening, bone capsule sample becomes, blood vessel dilatation, hyperemia, erythrocyte accumulation in Haversian canal.Control group (B), articular cartilage surface is thick Rough, hyperplasia that articular chondrocytes are slight, cell arrangement owes rule, and the 4 stratum boundaries limit of cartilage lacks unity and coherence, but can still recognize.Calcification Layer has a small amount of cell to be dispersed in hyperplasia, and damp line part is present.Blood vessel is slightly expanded in subchondral bone Haversian canal, has erythrocyte accumulation to show As.Treatment group (A), top layer cartilage cell has obvious division and proliferation, and several cells or nucleus are located in same cartilage cavities, increase Raw cartilage cell is in ellipse circular.The stratum boundary of cartilage 4 limit is clearer, indivedual performance cartilage cell's irregular arrangements.Being counted up to damp line more Whole, indivedual imperfect, Haversian canal blood vessel has no expansion.The total lesion of A groups is substantially lighter than B, C group.

（3）Tectology quantitative observation

Itself left and right control blank group (C) Ipsilateral articular cartilage through thickness and non-calcified cartilage thickness are relatively good for side and substantially shown Reduce, difference has highly significant meaning (P<0.01), and calcified cartilage thickness then increased, difference significance (P< 0.05)；Control group (B) articular cartilage through thickness or so changes in contrast is little, difference nonsignificance, (P>, but non-calcium 0.05) Cartilage thickness Ipsilateral is relatively good for side and reduced, and calcified cartilage thickness is relatively good for side and increased, and both (divide difference significance Other P<0.05,P<0.01)；Treatment group (A) articular cartilage through thickness Ipsilateral is relatively good for side and increased, difference significance (P< 0.05), it is mainly shown as that non-calcified cartilage thickness Ipsilateral is relatively good for side and substantially increased, difference has highly significant meaning (P<0.01), Calcified cartilage thickness or so contrast difference's nonsignificance (P>0.05), it is shown in Table 1.

Each group UZ/CZ odds ratios are compared with both normal group (D) and treatment group (A) difference nonsignificance (P>0.05), and The UZ/CZ odds ratios of normal group, treatment group and blank group are compared with difference has highly significant meaning (P<0.01), control group and sky White group UZ/CZ odds ratios are compared with difference nonsignificance (P>0.05) 2, are shown in Table.

&&：Variance analysis p<0.01;**:Q examines P<0.01;#:Q examines P>0.05.

Conclusion：From upper experiment, the present invention has anti-regression to act on to rabbit knee degenerative osteoarthropathy model.

Experimental example 2：Anxious poison experimental study

1. experimental method：

Kunming mouse, through prerun, gives gavage of small white mouse medicine agent of the present invention（Carried out according to the method for embodiment 1 Prepare）Equal 1mL/20g, death is not caused, the concentration and administered volume for being limited to medicine can not increase, it is impossible to measure median lethal dose (LD50), thus carry out maximum tolerance determination experiment.The healthy Kunming mouse 20 of selection, weight (20 ± 2) g, male and female are each Divide 2 times in half, with 24 hours and gavage pharmaceutical composition paste of the present invention, 1mL/ times, total amount reaches 100mL/kg, equivalent to 163g/kg crude drugs.200 times of this dosage equivalent to Coming-of-Age Day dosing.

2. experimental result

Mouse had no adverse reaction, whole bouncings, weight increase, no death to observation post administration 7 days.

Compared with prior art, the present invention is from the red sage root, giant knotweed, caulis lonicerae, the windproof, root bark of tree peony, radix scutellariae, the root of Chinese clematis, bark of ash With barrenwort prescription.With promoting blood circulation, dispelling wind and eliminating dampness, the effect of clearing away heat to and alleviating pain.Be mainly used in caused by liver and kidney deficiency, rheumatism retardance and Blood stasis and osteoarthritis for causing etc., symptoms include bone joint pain, bone weight is difficult to be lifted, arthroncus, textured bone.The curative effect of medication being made Significantly, toxic side effect is small, reaches goal of the invention.

The present invention is further illustrated by the following examples, but not as limitation of the present invention.

Embodiment：

Embodiment 1：

Prescription：Red sage root 12g, giant knotweed 12g, caulis lonicerae 12g, windproof 9g, root bark of tree peony 9g, radix scutellariae 9g, root of Chinese clematis 12g, bark of ash 9g, Barrenwort 9g.

Technique：The red sage root, giant knotweed, caulis lonicerae, the windproof, root bark of tree peony, radix scutellariae, the root of Chinese clematis, bark of ash and barrenwort are taken, two are added water to cook Secondary, the decocting that 10 times of amounts are added for the first time is boiled 2 hours, adds 8 times of amount decoctings to boil for the second time 1.5 hours, collecting decoction, decocting liquid filter Cross, relative density is 1.20~1.25 clear cream when filtrate is concentrated into 60 DEG C, take dextrin, the 20% soluble shallow lake of the amount of being made 20% Powder and 0.15% Aspartame are added in above-mentioned clear cream, mix, particle is made with 75% ethanol, wet granular is done at 65 DEG C Dry, whole grain, filling produces granule.

Usage and dosage：Orally.Three times per day, a 15g~30g.

Embodiment 2：

Prescription：Red sage root 20g, giant knotweed 20g, caulis lonicerae 20g, windproof 15g, root bark of tree peony 15g, radix scutellariae 15g, root of Chinese clematis 20g, bark of ash 15g, barrenwort 15g.

Technique：The red sage root, giant knotweed, caulis lonicerae, the windproof, root bark of tree peony, radix scutellariae, the root of Chinese clematis, bark of ash and barrenwort are taken, two are added water to cook It is secondary, the water of 10 times of amounts is added for the first time, is decocted 2 hours, and the water of second plus 8 times amount is decocted 1.5 hours；Collecting decoction, decocting liquid Filtration, relative density is 1.20~1.25 clear cream when filtrate is concentrated into 60 DEG C, takes dextrin, 10% solubility of the amount of being made 10% Starch and 3% magnesium stearate are added in above-mentioned clear cream, are mixed, with 75% alcohol granulation, are dried wet granular at 65 DEG C, whole Grain, filling, every 0.5g produces capsule.

Usage and dosage：Orally.Three times per day, one time 2~4.

Embodiment 3：

Prescription：Red sage root 15g, giant knotweed 15g, caulis lonicerae 15g, windproof 10g, root bark of tree peony 10g, radix scutellariae 10g, root of Chinese clematis 15g, bark of ash 10g, barrenwort 10g.

Technique：The red sage root, giant knotweed, caulis lonicerae, the windproof, root bark of tree peony, radix scutellariae, the root of Chinese clematis, bark of ash and barrenwort are taken, two are added water to cook It is secondary, the water of 10 times of amounts is added for the first time, is decocted 2 hours, and the water of second plus 8 times amount is decocted 1.5 hours；Collecting decoction, decocting liquid Filtration, relative density is 1.20~1.25 clear cream when filtrate is concentrated into 60 DEG C, and clear cream adds the starch and 10% of the amount of being made 20% Carboxymethyl cellulose, mix, use 70% alcohol granulation, tabletting is coated, and every 0.5g produces tablet.

Usage and dosage：Orally.Three times per day, one time 2~4.

Claims (8)

1. a kind of medicine for treating Osteoarthritis, it is characterised in that：Calculate in parts by weight, by 12 parts of the red sage root, 12 parts of giant knotweed, 12 parts of caulis lonicerae, windproof 9 parts, 9 parts of the root bark of tree peony, 9 parts of radix scutellariae, 12 parts of the root of Chinese clematis, 9 parts of bark of ash, 9 parts of barrenwort and auxiliary material are made.

2. a kind of preparation method of the medicine for the treatment of Osteoarthritis as claimed in claim 1, it is characterised in that：Proportionally claim Take acceptable in the red sage root, giant knotweed, caulis lonicerae, the windproof, root bark of tree peony, radix scutellariae, the root of Chinese clematis, bark of ash and barrenwort, with medicine medicinal Auxiliary material is combined, and is processed according to conventional preparation method, and corresponding pharmaceutical preparation is made.

3. the preparation method of the medicine of Osteoarthritis is treated as claimed in claim 2, it is characterised in that：Take the red sage root, giant knotweed, bear Winter rattan, the windproof, root bark of tree peony, radix scutellariae, the root of Chinese clematis, bark of ash and barrenwort, add the 6-12 times of water measured, decoct 1-3 times, each 1-3 is small When, decocting liquid filtration, filtrate is condensed into clear cream, is combined with acceptable pharmaceutic adjuvant in medicine, and according to conventional system Preparation Method is processed, and corresponding pharmaceutical preparation is made.

4. the preparation method of the medicine of Osteoarthritis is treated as claimed in claim 3, it is characterised in that：Take the red sage root, giant knotweed, bear Winter rattan, the windproof, root bark of tree peony, radix scutellariae, the root of Chinese clematis, bark of ash and barrenwort, add water to cook it is secondary, for the first time plus 10 times of amount decoctings to boil 2 small When, second plus 8 times of amount decoctings boil 1.5 hours, collecting decoction, filtration, when filtrate is concentrated into 60 DEG C relative density be 1.20~ 1.25 clear cream；It is combined, and is processed according to conventional preparation method with acceptable pharmaceutic adjuvant in medicine, is made Into corresponding pharmaceutical preparation.

5. the preparation method of the medicine of Osteoarthritis is treated as any one of claim 2-4, it is characterised in that：It is described Pharmaceutical preparation is granule, capsule or tablet.

6. the preparation method of the medicine of Osteoarthritis is treated as claimed in claim 5, it is characterised in that：The granule is so Prepare：Take the red sage root, giant knotweed, caulis lonicerae, the windproof, root bark of tree peony, radix scutellariae, the root of Chinese clematis, bark of ash and barrenwort, add water to cook it is secondary, first The secondary decocting for adding 10 times of amounts is boiled 2 hours, adds 8 times of amount decoctings to boil for the second time 1.5 hours, collecting decoction, decocting liquid filtration, filtrate is dense Relative density is 1.20~1.25 clear cream when being reduced to 60 DEG C, takes the dextrin of the amount of being made 20%, 20% soluble starch and 0.15% Sweetener add in above-mentioned clear cream, mix, particle be made with 75% ethanol, dries wet granular at 65 DEG C, whole grain, fill, Produce.

7. the preparation method of the medicine of Osteoarthritis is treated as claimed in claim 5, it is characterised in that：The capsule is so made It is standby：The red sage root, giant knotweed, caulis lonicerae, the windproof, root bark of tree peony, radix scutellariae, the root of Chinese clematis, bark of ash and barrenwort are taken, secondary, first time is added water to cook The water of 10 times of amounts is added, is decocted 2 hours, the water of second plus 8 times amount is decocted 1.5 hours；Collecting decoction, decocting liquid filtration, filtrate Relative density is 1.20~1.25 clear cream when being concentrated into 60 DEG C, takes the dextrin of the amount of being made 10%, 10% soluble starch and 3% Magnesium stearate add in above-mentioned clear cream, mix, with 75% alcohol granulation, dry wet granular at 65 DEG C, whole grain, fill, i.e., Obtain capsule.

8. the preparation method of the medicine of Osteoarthritis is treated as claimed in claim 5, it is characterised in that：The tablet is so made It is standby：The red sage root, giant knotweed, caulis lonicerae, the windproof, root bark of tree peony, radix scutellariae, the root of Chinese clematis, bark of ash and barrenwort are taken, secondary, first time is added water to cook The water of 10 times of amounts is added, is decocted 2 hours, the water of second plus 8 times amount is decocted 1.5 hours；Collecting decoction, decocting liquid filtration, filtrate Relative density is 1.20~1.25 clear cream when being concentrated into 60 DEG C, and the starch and 10% carboxymethyl that clear cream adds the amount of being made 20% are fine Dimension element, is mixed, and uses 70% alcohol granulation, and tabletting is coated, produced.