CN104546863B - 头孢噻吩钠在制备抑制肿瘤细胞转移和扩散的药物中的应用 - Google Patents
头孢噻吩钠在制备抑制肿瘤细胞转移和扩散的药物中的应用 Download PDFInfo
- Publication number
- CN104546863B CN104546863B CN201510066508.6A CN201510066508A CN104546863B CN 104546863 B CN104546863 B CN 104546863B CN 201510066508 A CN201510066508 A CN 201510066508A CN 104546863 B CN104546863 B CN 104546863B
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- CN
- China
- Prior art keywords
- cell
- cephalothin sodium
- medicine
- diffusion
- cephalothin
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
10uM | 5uM | 1uM | 0.5uM | 阳性对照 | 阴性对照 | |
单个细胞平均面积 | 8314.96 | 12097.71 | 11081.12 | 9111.75 | 9285.58 | 6084.43 |
Ration | 136.66% | 198.83% | 182.12% | 149.76% | 152.61% | - |
空白对照 | 0.5μM | 1μM | 5μM | 10μM | |
HT29 ( % ) | 100±3.62 | 38.21±2.63 | 20.37±3.45 | 16.39±3.58 | 34.67±3.92 |
空白对照 | 0.5μM | 1μM | 5μM | 10μM | |
HT29 ( % ) | 100±4.17 | 39.21±3.58 | 22.64±4.18 | 230.89±4.08 | 36.71±5.12 |
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201510066508.6A CN104546863B (zh) | 2015-02-09 | 2015-02-09 | 头孢噻吩钠在制备抑制肿瘤细胞转移和扩散的药物中的应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN201510066508.6A CN104546863B (zh) | 2015-02-09 | 2015-02-09 | 头孢噻吩钠在制备抑制肿瘤细胞转移和扩散的药物中的应用 |
Publications (2)
Publication Number | Publication Date |
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CN104546863A CN104546863A (zh) | 2015-04-29 |
CN104546863B true CN104546863B (zh) | 2016-09-14 |
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CN201510066508.6A Expired - Fee Related CN104546863B (zh) | 2015-02-09 | 2015-02-09 | 头孢噻吩钠在制备抑制肿瘤细胞转移和扩散的药物中的应用 |
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CN (1) | CN104546863B (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108066345A (zh) * | 2016-11-14 | 2018-05-25 | 武汉华杰世纪生物医药有限公司 | 一种具有抗肿瘤作用的化合物 |
CN108338982A (zh) * | 2017-12-27 | 2018-07-31 | 天津国际生物医药联合研究院 | 头孢噻吩钠在抗白血病的药物中的应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100785601B1 (ko) * | 2003-11-21 | 2007-12-14 | 화이자 프로덕츠 인크. | 백신 아쥬반트로서의 항생제의 용도 |
US20120114670A1 (en) * | 2007-10-02 | 2012-05-10 | University Of Rochester | Methods and compositions related to synergistic responses to oncogenic mutations |
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2015
- 2015-02-09 CN CN201510066508.6A patent/CN104546863B/zh not_active Expired - Fee Related
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Publication number | Publication date |
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CN104546863A (zh) | 2015-04-29 |
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C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Application of cefalotin sodium in preparation of medicine for inhibiting tumour cell transfer and diffusion Effective date of registration: 20181116 Granted publication date: 20160914 Pledgee: Bank of Nanjing, Limited by Share Ltd, Nanjing branch Pledgor: Jiangsu Aogemu Biological Technology Co., Ltd. Registration number: 2018320000307 |
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PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20211208 Granted publication date: 20160914 Pledgee: Bank of Nanjing Limited by Share Ltd. Nanjing branch Pledgor: JIANGSU AOGEMU BIOLOGICAL TECHNOLOGY Co.,Ltd. Registration number: 2018320000307 |
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