CN104544069A - Preparation method for hemp seed oil microcapsules - Google Patents
Preparation method for hemp seed oil microcapsules Download PDFInfo
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Abstract
The invention discloses a preparation method for hemp seed oil microcapsules. The preparation method comprises the following steps: (1) preparation of a wall material solution : taking maltodextrin, modified starch, Arabic gum and saccharose as main wall materials, and mixing the main wall materials and water to prepare the wall material solution; (2) sterilization: sterilizing the wall material solution; (3) emulsification: mixing and emulsifying the sterilized wall material solution and hemp seed oil to obtain an emulsion; (4) drying: spray-drying the emulsion to obtain the hemp seed oil microcapsules. The hemp seed oil microcapsules prepared by the method have the advantages of high oil content, high encapsulation rate, good stability and long quality guarantee period; the method is simple, lower in cost and conductive to practical production and application, and brings better economic benefits.
Description
Technical field
The present invention relates to the preparation method of vegetable fat microcapsules, particularly relate to a kind of preparation method of fructus cannabis oil microcapsules.
Background technology
Fire fiber crops are annual moraceae plants, are one of original plants of China.Fire fiber crops are as a kind of " long-lived fiber crops " of preciousness, trace element containing needed by human such as abundant vegetable protein, lecithin and the vitamin E delayed senility in a large number, selenium, zinc, manganese, germanium, also containing the a-leukotrienes being described as " plant docosapentaenoic acid ", can suppress irritated, anti-inflammatory disappears bacterium, has the effect of the qi-restoratives that relaxes bowel, nourishes.The numb seed oil content of fire reaches 30% ~ 35%, and fructus cannabis oil-containing reaches more than 50%, and in fructus cannabis oil, unrighted acid accounts for more than 85% of TFA, and content of vitamin E is also quite high, has larger value of exploiting and utilizing.
Fructus cannabis oil is as the extract of fructus cannabis, there is the effects such as hypotensive, diuresis, analgesia, anti-inflammatory, antithrombus formation, treatment constipation, delay senility, Improving memory power, long-term eating has good auxiliary curative effect to chronic forms inflammation, paralysis, constipation, hypertension, high fat of blood and gynecological disease etc., and external application can have auxiliary curative effect to neurodermatitis.Autonomous county of the Bama of Guangxi Yao nationality of China is one of large long-lived area, the world five, this area's longevity causes is except superior natural ecological environment, may be relevant with the habits and customs of the long-term edible hemp benevolence oil of its uniqueness, it is reported this area's angiocardiopathy, the atonic constipation incidence of disease is extremely low.
Fire fiber crops cultivation history long, China fire fiber crops cultivated area and output position at the forefront in the world, but about the scientific research in fiery ramie product field delayed far away.Fructus cannabis oil is as the extract of the numb dry mature fruit of fire, it is a kind of functional grease being rich in unrighted acid, there is edible and medical value widely, meet the demand of current people to health diet, can be developed as a kind of new type functional oil resource, be there is good development prospect.At present, the research of China's fructus cannabis oil is at the early-stage, and there are abundant variety source and wide consumption market in China, therefore, to the research further study of fructus cannabis oil, particularly needs to be studied in the producing of fructus cannabis oil.
In medicine and food compositions, the common formulation of vegetable fat preparation is soft capsule or microcapsules.If report in document " fructus cannabis oil progress " is about the microcapsules research of " cloud fiber crops No. ", its fructus cannabis oil and wall material are than being 3:4, wall material is gelatin and maltodextrin, its ratio is 4:6, add the emulsifying agent of 0.9%, proportioning is sucrose ester: monoglyceride=9:1, and the HLB value of emulsifying agent is 13.48.The microcapsule embedded rate 91.24% that last spraying dry obtains, oil content reaches 35.97%, and surface oil is 3.15%.Its embedding rate and oil content are not high, and surface oil is higher, illustrate that the microcapsules quality of gained is not ideal.Report the preparation method about seabuckthorn oil microcapsule in Chinese patent application CN103584081A " a kind of preparation method of seabuckthorn oil microcapsule ", its oil content can arrive 40.1%, reaches relatively high oil content.But gummi arabicum pulveratum needs in drying box dry to remove oxidizing ferment, complex process in its embedding process; The embedding stage needs to carry out adjust ph to 3.0-3.5 with HAc, whether the change of pH value has impact to come to a conclusion on microcapsule product, and microcapsules emulsion needs to maintain 45 ~ 55 DEG C in embedding process, distilled water is added after having adjusted pH value, its temperature will be cooled to 30 ~ 35 DEG C, the temperature that makes on the rocks is down to 10 DEG C rapidly afterwards, and the change of temperature is too complicated; Its drying mode is for dripping curing agent, natural sedimentation, vacuum freeze drying, and cost is high, and the cycle is long, may occur caking in various degree, poor fluidity.The preparation about linseed oil microcapsules and production method thereof is reported in Chinese patent application CN102934703A " a kind of linseed oil microcapsules and production method thereof ", its linseed oil carrying capacity can reach 45%, embedding rate >=90%, drugloading rate 19% in embodiment one, embedding rate can reach 95%; Drugloading rate 45% in example three, its embedding rate reduces to 90%; Visible, although better as composite wall material embedding effect using converted starch, maltodextrin and casein sodium, along with the raising of drugloading rate, embedding rate lowers very fast.Although its drugloading rate can reach 45%, its embedding rate only has 90%, can not carry out embedding protection well to linseed oil.
Summary of the invention
The object of the present invention is to provide a kind of preparation method of fructus cannabis oil microcapsules, the fructus cannabis oil microcapsules oil content that the method obtains is high, embedding rate is high, good stability, long shelf-life, and method is simple, and cost is lower, be conducive to production application, and bring good economic benefit.
For realizing object of the present invention, the present invention by the following technical solutions: a kind of preparation method of fructus cannabis oil microcapsules, comprises the following steps:
(1) prepare wall material solution: with maltodextrin, converted starch, Arabic gum and sucrose for main wall material, be mixed and made into wall material solution with water;
(2) sterilizing: sterilization treatment is carried out to wall material solution;
(3) emulsification: the wall material solution after sterilizing and fructus cannabis oil mixing and emulsifying obtain emulsion;
(4) dry: emulsion is spray-dried, obtain fructus cannabis oil microcapsules.
As an embodiment of the invention, in described wall material, maltodextrin, converted starch, Arabic gum and sucrose quality fraction are respectively:
Maltodextrin 40%-60%
Converted starch 20%-30%
Arabic gum 5%-15%
Sucrose 5%-15%.
Further, in described step (1), in wall material, also beta-schardinger dextrin-is comprised.As an embodiment of the invention, the mass fraction of described beta-schardinger dextrin-is greater than zero and is less than or equal to 5%.
In step of the present invention (1) wall material solution, solid quality degree is 40%-50%.
In step of the present invention (2), sterilising conditions is: sterilizing 30-50min at 75-95 DEG C of temperature.
In step of the present invention (3), after the wall material solution after sterilizing is cooled to 40-50 DEG C, mixes in the ratio that the mass ratio of wall material and fructus cannabis oil is 1:1-1:1.5 with fructus cannabis oil, be made into the emulsion that solid content is 30%-50%.
The present invention can do following improvement: before step of the present invention (4), increase high-pressure homogeneous treatment step, contact with the lipophilic group in wall material to be conducive to fructus cannabis oil, increase affinity between the two, to obtain the emulsion of stable homogeneous, improve wall material to the embedding effect of fructus cannabis oil.As one embodiment of the present of invention, the condition of described high-pressure homogeneous process is: first with pressure homogeneous 1-2 time of 10-30MPa, then with pressure homogeneous 2-3 time of 30-60MPa.
In step of the present invention (4), spray drying condition is: atomizer rotating speed is 16000-22000rpm/min, EAT 170-200 DEG C, leaving air temp 75-95 DEG C, feeding temperature 55-75 DEG C, and charging rate is 30-60L/h.This drying condition is applicable to the drying of emulsion and emulsion.
The present invention also can make further improvements: after described step (4), increase the process of fructus cannabis oil microcapsules resistive connection, namely in fructus cannabis oil microcapsules, add anticaking agent, lump in storage to avoid fructus cannabis oil microcapsules as far as possible.Particularly, with fructus cannabis oil microcapsules gross mass for Calculation Basis, the addition of described anticaking agent is below 1.5%.As one embodiment of the present of invention, described anticaking agent is silica.
compared with prior art, the present invention has the following advantages:
(1) in preparation method provided by the invention with nontoxic, stable, the natural macromolecular material maltodextrin of good film-forming property, converted starch, Arabic gum and sucrose are that the wall material that primary raw material is formed embeds fructus cannabis oil, embedding rate is high, can up to more than 98%, and embed effective, the microcapsules oil content of gained is high, can 50% be reached, surface oil content low (0.90%-1.80%), peroxide value low (0.042-0.084 g/100g), acid number low (0.35-0.95 mg/g), only need the heat-sealing of inner PE bag, outside aluminium foil bag heat-sealing, more than 2 years can be preserved at 25 DEG C, at 40 DEG C, the physicochemical property of product is still stablized, every morphological index, biochemical indicator and microbiological indicator all meet national standard.
(2) the microcapsules bulk density that obtains of preparation method of the present invention is high, is greater than 0.5g/ml.
(3) preparation method's cost provided by the invention is low, is conducive to the economic worth improving fructus cannabis oil microcapsules.
Converted starch has many advantages such as emulsion emulsifiers state is good, all even embedding of particle dispersion is effective, and during as microcapsule wall material, effective, without the need to adding emulsifying agent and thickener again, technique is simple; And converted starch easily obtains, source is wide, and material price is low, effectively reduces production cost.And maltodextrin low viscous feature when there is high concentration, after coordinating with converted starch, can improve the solid concentration of system, rapid dehydration evaporation in spray-drying process, film forming speed is fast, reduces the loss of wall core, is conducive to the formation of cyst wall, reduces production cost.
(4) the present invention selects spray drying process, and rate of drying is high, the time is short, and production process is simple and flexibly, convenient operation and control, is easy to realize large-scale industrialized production.And products obtained therefrom purity is high and have well dispersed and dissolubility, low production cost.
(5) technological process of preparation method of the present invention is simple, and workable, microcapsules yield is high, and environmental protection is pollution-free, reproducible, can realize heavy industrialization consecutive production, is conducive to the popularization of product.
Accompanying drawing explanation
Figure 1 shows that the stereoscan photograph of the fructus cannabis oil microcapsules that preparation method of the present invention obtains.
Detailed description of the invention
Below content of the present invention is elaborated, to understand principle and advantage of the present invention better.
Definition:
Peroxide value: represent with the percentage of iodine, unit is g/100g, and namely in acid condition, the peroxide in fat and excessive KI react and generate I
2, use Na
2s
2o
3the I that titration generates
2, the peroxide value of grease is calculated according to its consumption.
Acid value: use acid-base neutralization reaction assay, with in and the milligram number of potassium hydroxide that consumes needed for 1g fat free fatty acid represent.
Water content: the water content of fructus cannabis oil microcapsules, measures by seasoning.
Surface oil: the oil mass that fructus cannabis oil surface of microcapsule dissociates accounts for the percentage of the gross weight of these fructus cannabis oil microcapsules.Fructus cannabis oil surface of microcapsule oil is soluble in 30 ~ 60 DEG C of benzinums, and other compositions of microcapsules are insoluble to 30 ~ 60 DEG C of benzinums, adopts 30 ~ 60 DEG C of benzinums to get final product release surface oil and microcapsules, thus obtains surface oil weight.In following examples, the assay method of surface oil is:
Take fructus cannabis oil microcapsules sample 10g(accurately to 0.002g) in 100ml conical flask, add 30ml30 ~ 60 DEG C benzinum, put in shaking table with the rotating speed of 200rmp concussion 5min, filter, filtrate is placed in and dries the 50ml evaporating dish to constant weight (accurately to 0.002g) at 105 DEG C of baking ovens in advance.Filter residue is transferred in former conical flask, adds 30 ~ 60 DEG C of benzinums, and put concussion in shaking table and wash twice, each benzinum addition is 10ml; Filter, evaporating dish, in above-mentioned evaporating dish, is placed in 60 DEG C of water-baths (water-bath distilled water) and evaporates desolventizing, after solvent eliminates, then dry to constant weight in 105 DEG C of constant temperature ovens by merging filtrate, and cooling, weighs.
X（%）=（W
1-W
2）/W×100%
In formula: surperficial oil content in X---grease microcapsule, %
W---style quality, g
W
1---the weight of evaporating dish after constant weight, g
W
2---evaporating dish and the weight leaching oil after constant weight, g.
Yield: fructus cannabis oil microcapsules account for the mass percent of wall material and wall core.
embodiment 1
(1) wall material solution is prepared: with maltodextrin 49%, converted starch 22%, Arabic gum 10%, beta-schardinger dextrin-5% and sucrose 14% for wall material, under room temperature, add in material-compound tank, add water and make the wall material solution that solid content is 43%.
(2) sterilizing: wall material solution is sterilizing 40 min in 75 DEG C of water-baths.
(3) emulsification: after the wall material solution after sterilizing is cooled to 50 DEG C, mix with fructus cannabis oil, its mesospore material and fructus cannabis oil mass ratio are 1:1.5, stir 15 min, make it fully mix, and add water and are made into the emulsion of solid content 45%.
(4) high-pressure homogeneous: emulsion high pressure homogenizer step (3) obtained is with pressure 20 MPa(200 bar) homogeneous 2 times, with pressure 50 MPa(500 bar) homogeneous 3 times, obtain the emulsion of stable homogeneous.
(5) spraying dry: the emulsion that step (4) obtains is carried out spraying dry, atomizer rotating speed is 18000rpm/min, EAT 180 DEG C, leaving air temp 80 DEG C, feeding temperature 70 DEG C, charging rate is 50 L/h, obtain fructus cannabis oil microcapsules, add the silica of 1.5%.
Result: peroxide value 0.078 g/100g of the fructus cannabis oil microcapsules obtained, acid number 0.77 mg/g, water content 0.78%, oil content is 40%, and surface oil is 0.45%, and embedding rate is 99.1%, yield 86.61%.
embodiment 2
(1) wall material solution is prepared: with maltodextrin 53%, converted starch 21%, Arabic gum 11%, beta-schardinger dextrin-5% and sucrose 10% for wall material, under room temperature, add in material-compound tank, add water and make the wall material solution that solid content is 43%.
(2) sterilizing: wall material solution sterilizing 35min in 85 DEG C of water-baths.
(3) emulsification: after the wall material solution after sterilizing is cooled to 50 DEG C, mix with fructus cannabis oil, its mesospore material and fructus cannabis oil mass ratio are 1:1.25, stir 15 min, make it fully mix, and add water and are made into the emulsion of solid content 47%.
(4) high-pressure homogeneous: emulsion high pressure homogenizer step (3) obtained is with pressure 25 MPa(250 bar) homogeneous 2 times, then with pressure 55 MPa(550 bar) homogeneous 2 times, obtain the emulsion of stable homogeneous.
(5) spraying dry: the emulsion spraying dry that step (4) is obtained, atomizer rotating speed is 20000rpm/min, EAT 190 DEG C, leaving air temp 90 DEG C, feeding temperature 70 DEG C, charging rate is 60 L/h, obtain fructus cannabis oil microcapsules, add the silica of 1.0%.
Result: peroxide value 0.083 g/100g of the fructus cannabis oil microcapsules obtained, acid number 0.61 mg/g, water content 0.78%, oil content is 44.4%, and surface oil is 0.93%, and embedding rate is 98.14%, yield 87.14%.
embodiment 3
(1) wall material solution is prepared: with maltodextrin 57%, converted starch 21%, Arabic gum 10%, beta-schardinger dextrin-5% and sucrose 6% for wall material, under room temperature, add in material-compound tank, add water and make the wall material solution that solid content is 43%.
(2) sterilizing: wall material solution sterilizing 30min in 95 DEG C of water-baths.
(3) emulsification: after the wall material solution after sterilizing is cooled to 50 DEG C, mix with fructus cannabis oil, its mesospore material and fructus cannabis oil mass ratio are 1:1, stir 15 min, make it fully mix, and add water and are made into the emulsion of solid content 50%.
(4) high-pressure homogeneous: emulsion high pressure homogenizer step (3) obtained is with pressure 30MPa(300bar) homogeneous 2 times, then pressure 60MPa(600bar) homogeneous 2 times, obtain the emulsion of stable homogeneous, 50 DEG C of insulation 60min.
(5) spraying dry: the emulsion spraying dry that step (4) is obtained, atomizer rotating speed is 16000rpm/min, EAT 180 DEG C, leaving air temp 80 DEG C, feeding temperature 60 DEG C, charging rate is 40L/h, obtain fructus cannabis oil microcapsules, add the silica of 0.5%.
Result: peroxide value 0.069 g/100g of the fructus cannabis oil microcapsules obtained, acid number 0.43 mg/g, water content 0.97%, oil content is 50%, and surface oil is 1.19%, and embedding rate is 97.62%, yield 88.27%.
embodiment 4
(1) wall material solution is prepared: with maltodextrin 40%, converted starch 30%, Arabic gum 12%, beta-schardinger dextrin-3% and sucrose 15% for wall material, under room temperature, add in material-compound tank, add water and make the wall material solution that solid content is 45%.
(2) sterilizing: wall material solution sterilizing 30min in 95 DEG C of water-baths.
(3) emulsification: after the wall material solution after sterilizing is cooled to 50 DEG C, mix with fructus cannabis oil, its mesospore material and fructus cannabis oil mass ratio are 1:1, stir 15 min, make it fully mix, and add water and are made into the emulsion of solid content 50%.
(4) high-pressure homogeneous: emulsion high pressure homogenizer step (3) obtained is with pressure 30MPa(300bar) homogeneous 2 times, then with pressure 60MPa(600bar) homogeneous 2 times, obtain the emulsion of stable homogeneous, 50 DEG C of insulation 60min.
(5) spraying dry: the emulsion spraying dry that step (4) is obtained, atomizer rotating speed is 16000rpm/min, EAT 185 DEG C, leaving air temp 85 DEG C, feeding temperature 65 DEG C, charging rate is 45L/h, obtain fructus cannabis oil microcapsules, add the silica of 1.2%.
Result: peroxide value 0.069 g/100g of the fructus cannabis oil microcapsules obtained, acid number 0.43 mg/g, water content 0.84%, oil content is 50%, and surface oil is 0.66%, and embedding rate is 98.68%, yield 88.13%.
embodiment 5
(1) wall material solution is prepared: with maltodextrin 45%, converted starch 30%, Arabic gum 9%, beta-schardinger dextrin-3% and sucrose 13% for wall material, under room temperature, add in material-compound tank, add water and make the wall material solution that solid content is 50%.
(2) sterilizing: wall material solution sterilizing 30min in 85 DEG C of water-baths.
(3) emulsification: after the wall material solution after sterilizing is cooled to 50 DEG C, mix with fructus cannabis oil, its mesospore material and fructus cannabis oil mass ratio are 1:1.5, stir 15 min, make it fully mix, and add water and are made into the emulsion of solid content 50%.
(4) high-pressure homogeneous: emulsion high pressure homogenizer step (3) obtained is with pressure 30MPa(300bar) homogeneous 2 times, then with pressure 60MPa(600bar) homogeneous 2 times, obtain the emulsion of stable homogeneous, 50 DEG C of insulation 60min.
(5) spraying dry: the emulsion spraying dry that step (4) is obtained, atomizer rotating speed is 16000rpm/min, EAT 190 DEG C, leaving air temp 90 DEG C, feeding temperature 75 DEG C, charging rate is 40L/h, obtain fructus cannabis oil microcapsules, add the silica of 0.3%.
Result: peroxide value 0.069 g/100g of the fructus cannabis oil microcapsules obtained, acid number 0.43 mg/g, water content 0.92%, oil content is 50%, and surface oil is 0.52%, and embedding rate is 98.96%, yield 87.69%.
embodiment 6
(1) wall material solution is prepared: with maltodextrin 55%, converted starch 25%, Arabic gum 6%, beta-schardinger dextrin-5% and sucrose 9% for wall material, under room temperature, add in material-compound tank, add water and make the wall material solution that solid content is 40%.
(2) sterilizing: wall material solution sterilizing 30min in 95 DEG C of water-baths.
(3) emulsification: after the wall material solution after sterilizing is cooled to 50 DEG C, mix with fructus cannabis oil, its mesospore material and fructus cannabis oil mass ratio are 1:1.3, stir 15 min, make it fully mix, and add water and are made into the emulsion of solid content 50%.
(4) high-pressure homogeneous: emulsion high pressure homogenizer step (3) obtained is with pressure 30MPa(300bar) homogeneous 2 times, then with pressure 60MPa(600bar) homogeneous 2 times, obtain the emulsion of stable homogeneous, 50 DEG C of insulation 60min.
(5) spraying dry: the emulsion spraying dry that step (4) is obtained, atomizer rotating speed is 16000rpm/min, EAT 170 DEG C, leaving air temp 80 DEG C, feeding temperature 60 DEG C, charging rate is 50L/h, obtain fructus cannabis oil microcapsules, add the silica of 0.8%.
Result: peroxide value 0.069 g/100g of the fructus cannabis oil microcapsules obtained, acid number 0.43 mg/g, water content 0.99%, oil content is 50%, and surface oil is 1.27%, and embedding rate is 97.46%, yield 87.89%.
embodiment 7
(1) wall material solution is prepared: with maltodextrin 57%, converted starch 21%, Arabic gum 10%, beta-schardinger dextrin-5% and sucrose 7% for wall material, under room temperature, add in material-compound tank, add water and make the wall material solution that solid content is 43%.
(2) sterilizing: wall material solution sterilizing 30min in 95 DEG C of water-baths.
(3) emulsification: after the wall material solution after sterilizing is cooled to 50 DEG C, mix with fructus cannabis oil, its mesospore material and fructus cannabis oil mass ratio are 1:1.4, stir 15 min, make it fully mix, and add water and are made into the emulsion of solid content 50%.
(4) high-pressure homogeneous: emulsion high pressure homogenizer step (3) obtained is with pressure 20MPa(200bar) homogeneous 2 times, then with pressure 30MPa(300bar) homogeneous 2 times, obtain the emulsion of stable homogeneous, 50 DEG C of insulation 60min.
(5) spraying dry: emulsion spraying dry step (4) obtained, atomizer rotating speed is 22000rpm/min, EAT 200 DEG C, leaving air temp 90 DEG C, feeding temperature 70 DEG C, and charging rate is 35L/h, obtains fructus cannabis oil microcapsules.
Result: peroxide value 0.074 g/100g of the fructus cannabis oil microcapsules obtained, acid number 0.44 mg/g, water content 1.01%, oil content is 50%, and surface oil is 1.29%, and embedding rate is 97.42%, yield 88.04%.
embodiment 8
(1) wall material solution is prepared: with maltodextrin 60%, converted starch 22%, Arabic gum 12% and sucrose 6% for wall material, under room temperature, add in material-compound tank, add water and make the wall material solution that solid content is 43%.
(2) sterilizing: wall material solution sterilizing 45min in 85 DEG C of water-baths.
(3) emulsification: after the wall material solution after sterilizing is cooled to 50 DEG C, mix with fructus cannabis oil, its mesospore material and fructus cannabis oil mass ratio are 1:1, stir 15 min, make it fully mix, and add water and are made into the emulsion of solid content 50%.
(4) high-pressure homogeneous: emulsion high pressure homogenizer step (3) obtained is with pressure 15MPa(150bar) homogeneous 2 times, then with pressure 50MPa(500bar) homogeneous 2 times, obtain the emulsion of stable homogeneous, 50 DEG C of insulation 60min.
(5) spraying dry: emulsion spraying dry step (4) obtained, atomizer rotating speed is 16000rpm/min, EAT 170 DEG C, leaving air temp 80 DEG C, feeding temperature 60 DEG C, and charging rate is 40L/h, obtains fructus cannabis oil microcapsules.
Result: peroxide value 0.082 g/100g of the fructus cannabis oil microcapsules obtained, acid number 0.47 mg/g, water content 0.98%, oil content is 50%, and surface oil is 1.51%, and embedding rate is 96.98%, yield 87.79%.
The present invention can summarize with other the concrete form without prejudice to spirit of the present invention or principal character.Above-mentioned embodiment of the present invention all can only be thought explanation of the present invention instead of restriction, therefore every above embodiment is done according to substantial technological of the present invention any trickle amendment, equivalent variations and modification, all belong in the scope of technical solution of the present invention.
Claims (10)
1. a preparation method for fructus cannabis oil microcapsules, is characterized in that, comprises the following steps:
(1) prepare wall material solution: with maltodextrin, converted starch, Arabic gum and sucrose for main wall material, be mixed and made into wall material solution with water;
(2) sterilizing: sterilization treatment is carried out to wall material solution;
(3) emulsification: the wall material solution after sterilizing and fructus cannabis oil mixing and emulsifying obtain emulsion;
(4) dry: emulsion is spray-dried, obtain fructus cannabis oil microcapsules.
2. the preparation method of fructus cannabis oil microcapsules according to claim 1, it is characterized in that, in described wall material, maltodextrin, converted starch, Arabic gum and sucrose quality fraction are respectively:
Maltodextrin 40%-60%
Converted starch 20%-30%
Arabic gum 5%-15%
Sucrose 5%-15%.
3. the preparation method of fructus cannabis oil microcapsules according to claim 1 or 2, is characterized in that, in described step (1), also comprise beta-schardinger dextrin-in wall material.
4. the preparation method of fructus cannabis oil microcapsules according to claim 3, it is characterized in that, the mass fraction of described beta-schardinger dextrin-is greater than zero and is less than or equal to 5%.
5. the preparation method of fructus cannabis oil microcapsules according to any one of Claims 1-4, it is characterized in that, in described step (1) wall material solution, solid quality degree is 40%-50%.
6. the preparation method of fructus cannabis oil microcapsules according to claim 5, it is characterized in that, in described step (2), sterilising conditions is: sterilizing 30-50min at 75-95 DEG C of temperature.
7. the preparation method of fructus cannabis oil microcapsules according to claim 6, it is characterized in that, in described step (3), after wall material solution after sterilizing is cooled to 40-50 DEG C, mix in the ratio that the mass ratio of wall material and fructus cannabis oil is 1:1-1:1.5 with fructus cannabis oil, be made into the emulsion that solid content is 30%-50%.
8. the preparation method of fructus cannabis oil microcapsules according to claim 1 or 7, it is characterized in that, high-pressure homogeneous treatment step is increased before step (4), the condition of this high-pressure homogeneous process is: first with pressure homogeneous 1-2 time of 10-30MPa, then with pressure homogeneous 2-3 time of 30-60MPa.
9. the preparation method of fructus cannabis oil microcapsules according to claim 8, it is characterized in that, fructus cannabis oil microcapsules resistive connection treatment step is increased after described step (4), namely in fructus cannabis oil microcapsules, anticaking agent is added, with fructus cannabis oil microcapsules gross mass for Calculation Basis, the addition of described anticaking agent is below 1.5%; Described anticaking agent is silica.
10. the preparation method of fructus cannabis oil microcapsules according to claim 9, it is characterized in that, in described step (4), spray drying condition is: atomizer rotating speed is 16000-22000rpm/min, EAT 180-200 DEG C, leaving air temp 75-95 DEG C, feeding temperature 55-75 DEG C, charging rate is 30-50L/h.
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| CN108486713A (en) * | 2018-03-22 | 2018-09-04 | 詹晨燕 | A kind of ultra-fine nylon yarn and preparation method thereof |
| CN109549191A (en) * | 2017-09-26 | 2019-04-02 | 无限极（中国）有限公司 | A kind of fructus cannabis oil microcapsules and its preparation method and application |
| CN109619487A (en) * | 2018-10-26 | 2019-04-16 | 华中农业大学 | Composition and preparation method thereof with function of relaxing bowel |
| CN109705979A (en) * | 2019-01-22 | 2019-05-03 | 双凯食品配料（昆山）有限公司 | A kind of application of microcapsules technology in pig ester oil powder |
| CN111466448A (en) * | 2020-04-14 | 2020-07-31 | 劲牌持正堂药业有限公司 | Preparation method of high-water-solubility fructus cannabis extract |
| CN111643377A (en) * | 2020-07-23 | 2020-09-11 | 中国热带农业科学院南亚热带作物研究所 | Hemp oil nano microcapsule and preparation method and application thereof |
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| CN112545036A (en) * | 2020-12-11 | 2021-03-26 | 广西科技大学 | Garlic fruit oil microcapsule and preparation method thereof |
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| US20220087972A9 (en) * | 2016-04-15 | 2022-03-24 | Sre Wellness, Inc. | Cannabinoid Compositions |
| CN109549191A (en) * | 2017-09-26 | 2019-04-02 | 无限极（中国）有限公司 | A kind of fructus cannabis oil microcapsules and its preparation method and application |
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| CN111466448A (en) * | 2020-04-14 | 2020-07-31 | 劲牌持正堂药业有限公司 | Preparation method of high-water-solubility fructus cannabis extract |
| CN111643377A (en) * | 2020-07-23 | 2020-09-11 | 中国热带农业科学院南亚热带作物研究所 | Hemp oil nano microcapsule and preparation method and application thereof |
| CN111643377B (en) * | 2020-07-23 | 2023-08-11 | 中国热带农业科学院南亚热带作物研究所 | Hemp seed oil nano microcapsule and preparation method and application thereof |
| CN112167598A (en) * | 2020-10-15 | 2021-01-05 | 吉源(淮北)食品科技有限公司 | Preparation method of microcapsule particle slow-release coating essence |
| CN114431471A (en) * | 2020-10-19 | 2022-05-06 | 中恩（天津）医药科技有限公司 | Oil microcapsule powder, preparation method and application |
| CN112545036A (en) * | 2020-12-11 | 2021-03-26 | 广西科技大学 | Garlic fruit oil microcapsule and preparation method thereof |
| CN114711427A (en) * | 2020-12-22 | 2022-07-08 | 云南汉盟制药有限公司 | Microcapsule and preparation method and application thereof |
| CN112726212A (en) * | 2020-12-24 | 2021-04-30 | 罗莱生活科技股份有限公司 | Nicotinamide skin-care textile and preparation method thereof |
| CN113180223A (en) * | 2021-04-19 | 2021-07-30 | 幺麻子食品股份有限公司 | Preparation method of zanthoxylum schinifolium oil microcapsule and preparation method of zanthoxylum schinifolium monosodium glutamate |
| CN113951486A (en) * | 2021-11-01 | 2022-01-21 | 北京麦克基普健康科技有限公司 | Whole fructus cannabis powder and preparation method and application thereof |
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