CN104541153B - 涉及利用光纤拉曼光谱的内窥镜进行实时癌症诊断的方法 - Google Patents

涉及利用光纤拉曼光谱的内窥镜进行实时癌症诊断的方法 Download PDF

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CN104541153B
CN104541153B CN201380035488.5A CN201380035488A CN104541153B CN 104541153 B CN104541153 B CN 104541153B CN 201380035488 A CN201380035488 A CN 201380035488A CN 104541153 B CN104541153 B CN 104541153B
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fiber optic
probe
raman
raman spectroscopy
spectrometer
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CN104541153A (zh
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黄志伟
何凯俞
马兹·西尔维斯特·博格霍尔特
郑伟
杨凯关
西亚马拉·杜莱潘点
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National University of Singapore
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00163—Optical arrangements
    • A61B1/00165—Optical arrangements with light-conductive means, e.g. fibre optics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
    • G01N21/274—Calibration, base line adjustment, drift correction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/02—Operational features
    • A61B2560/0223—Operational features of calibration, e.g. protocols for calibrating sensors
    • A61B2560/0228—Operational features of calibration, e.g. protocols for calibrating sensors using calibration standards
    • A61B2560/0233—Optical standards
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G01J2003/4424—Fluorescence correction for Raman spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N2021/653—Coherent methods [CARS]
    • G01N2021/656—Raman microprobe
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/08—Optical fibres; light guides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/12—Circuits of general importance; Signal processing
    • G01N2201/127—Calibration; base line adjustment; drift compensation
    • G01N2201/12746—Calibration values determination
    • G01N2201/12753—Calibration values determination and storage
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/12—Circuits of general importance; Signal processing
    • G01N2201/129—Using chemometrical methods

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Theoretical Computer Science (AREA)
  • Mathematical Physics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Endoscopes (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Spectrometry And Color Measurement (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
CN201380035488.5A 2012-07-02 2013-07-02 涉及利用光纤拉曼光谱的内窥镜进行实时癌症诊断的方法 Active CN104541153B (zh)

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US201261667384P 2012-07-02 2012-07-02
US61/667,384 2012-07-02
GB1307338.2 2013-04-23
GB1307338.2A GB2513343A (en) 2013-04-23 2013-04-23 Methods related to instrument-independent measurements for quantitative analysis of fiber-optic Raman spectroscopy
PCT/SG2013/000273 WO2014007759A1 (en) 2012-07-02 2013-07-02 Methods related to real-time cancer diagnostics at endoscopy utilizing fiber-optic raman spectroscopy

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CN104541153B true CN104541153B (zh) 2017-12-05

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EP (1) EP2870462B1 (enExample)
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KR (1) KR101947859B1 (enExample)
CN (1) CN104541153B (enExample)
CA (1) CA2917308C (enExample)
ES (1) ES2930428T3 (enExample)
GB (1) GB2513343A (enExample)
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11699102B2 (en) 2017-02-28 2023-07-11 Verily Life Sciences Llc System and method for multiclass classification of images using a programmable light source
US12433488B2 (en) 2018-01-17 2025-10-07 14336186 Canada Corp. (Exclaro) System and methods for real time raman spectroscopy for cancer detection

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6560485B2 (ja) * 2014-04-17 2019-08-14 ローム株式会社 診断システム
WO2014175223A1 (ja) 2013-04-22 2014-10-30 ローム株式会社 癌診断装置、診断システム、診断装置
GB201315195D0 (en) * 2013-08-23 2013-10-09 Perkinelmer Uk Ltd Identifying presence of substances
DE102014003386B4 (de) * 2014-03-07 2016-06-23 Celltool Gmbh Verfahren und Vorrichtung zur Qualitätskontrolle eines Blutprodukts
WO2015154187A1 (en) * 2014-04-08 2015-10-15 Polyvalor, Limited Partnership System and method for assessing a cancer status of biological tissue
ES2847230T3 (es) * 2014-07-02 2021-08-02 Nat Univ Singapore Sistema, aparato y procedimiento de espectroscopía RAMAN para analizar, caracterizar y/o diagnosticar un tipo o naturaleza de una muestra o un tejido, tal como un crecimiento anómalo
CN104116497B (zh) * 2014-07-22 2016-10-05 中国科学院自动化研究所 内窥式光学分子影像导航系统和多光谱成像方法
CA2959256A1 (en) * 2014-08-29 2016-03-03 Synaptive Medical (Barbados) Inc. Molecular cell imaging using optical spectroscopy
WO2016132367A1 (en) * 2015-02-19 2016-08-25 Ramot At Tel-Aviv University Ltd. Chest radiograph (cxr) image analysis
WO2017024145A1 (en) 2015-08-05 2017-02-09 Canon U.S.A., Inc. Forward and angle view endoscope
CN106691549A (zh) * 2015-08-13 2017-05-24 复旦大学附属肿瘤医院 一种带有光纤探针的穿刺活检针
CN106420041A (zh) * 2015-08-13 2017-02-22 复旦大学附属肿瘤医院 一种带有光纤探针的高频手术电刀
CN117434627A (zh) * 2015-08-26 2024-01-23 新加坡国立大学 用于保持微球体的膜
US11668653B2 (en) 2015-11-16 2023-06-06 Chemimage Corporation Raman-based immunoassay systems and methods
CN105534470B (zh) * 2015-12-22 2018-01-30 精微视达医疗科技（武汉）有限公司 一种共焦显微内窥镜系统及其调节方法
US10444146B2 (en) 2015-12-28 2019-10-15 Canon U.S.A., Inc. Optical probe, light intensity detection, imaging method and system
US10365229B2 (en) * 2015-12-31 2019-07-30 Kaiser Optical Systems, Inc. Real-time characterization of pharmaceutical tablet coatings using Raman spectroscopy
WO2017139657A1 (en) * 2016-02-12 2017-08-17 Canon U.S.A., Inc. Simple monolithic optical element for forward-viewing spectrally encoded endoscopy
CN109068969B (zh) * 2016-03-10 2021-08-27 比奥普-医疗有限公司 诊断组织的装置
KR101778047B1 (ko) * 2016-04-04 2017-09-13 스페클립스 주식회사 질병 진단과 피부 나이 측정이 가능한 시스템과 이에 사용되는 핸드피스
US11131622B2 (en) * 2016-05-06 2021-09-28 Sony Corporation Information processing device, information processing method, and information processing system
CN105997000B (zh) * 2016-05-30 2023-04-14 福建师范大学 一种基于纤维内窥镜的拉曼光谱检测装置及其实现方法
WO2017212307A1 (en) 2016-06-06 2017-12-14 Hajdu Imre Diagnostic medical device
US10321810B2 (en) 2016-06-13 2019-06-18 Canon U.S.A., Inc. Spectrally encoded endoscopic probe having a fixed fiber
JP2019527576A (ja) 2016-07-15 2019-10-03 キヤノン ユーエスエイ, インコーポレイテッドCanon U.S.A., Inc スペクトル符号化プローブ
US10429240B2 (en) 2016-07-29 2019-10-01 Viavi Solutions Inc. Transfer of a calibration model using a sparse transfer set
US10984519B2 (en) * 2016-08-03 2021-04-20 Panduit Corp. Method for evaluating the optical insertion loss of a mechanical splice joint of two optical fibers
CN106092996B (zh) * 2016-08-03 2024-03-15 复旦大学 一种基于自体荧光寿命的癌症诊断系统
WO2018057924A1 (en) 2016-09-23 2018-03-29 Canon U.S.A. Inc. Spectrally encoded endoscopy apparatus and methods
KR102684214B1 (ko) 2016-10-18 2024-07-10 삼성전자주식회사 스펙트럼 안정성 모니터링 장치 및 방법
JP2018094395A (ja) 2016-11-03 2018-06-21 キヤノン ユーエスエイ, インコーポレイテッドCanon U.S.A., Inc 診断用スペクトル符号化内視鏡検査装置およびシステム、ならびにこれらと共に使用するための方法
CN108169200B (zh) * 2016-12-07 2020-12-22 同方威视技术股份有限公司 用于校准拉曼光谱检测装置的方法
US10371642B2 (en) * 2016-12-08 2019-08-06 The Board Of Trustees Of The Leland Stanford Junior University Raman topography system and methods of imaging
CN106923781A (zh) * 2017-03-28 2017-07-07 戎创前沿科技(北京)有限公司 一种拉曼胃镜诊断仪
US10753805B2 (en) 2017-04-05 2020-08-25 Kaiser Optical Systems Inc. Radiation shield for near-infrared detectors
FR3065285B1 (fr) * 2017-04-14 2019-07-05 Commissariat A L'energie Atomique Et Aux Energies Alternatives Procede d’acquisition d’un spectre
US10801963B2 (en) 2018-08-22 2020-10-13 Paul Bartholomew Raman spectroscopy for minerals identification
WO2019030749A1 (en) 2017-08-06 2019-02-14 Biop - Medical Ltd Optical probe for cervical examination
CN107320062B (zh) * 2017-08-11 2023-07-25 山东大学齐鲁医院 一种带有活体实时拉曼光谱检测的膀胱镜及方法
KR102542371B1 (ko) * 2017-08-22 2023-06-13 라이카 바이오시스템즈 멜버른 피티와이 엘티디 조직 처리기에 의해 처리될 조직 샘플을 모니터링하는 시스템 및 방법
US10825152B2 (en) 2017-09-14 2020-11-03 Canon U.S.A., Inc. Distortion measurement and correction for spectrally encoded endoscopy
CN108007910B (zh) * 2017-12-28 2023-12-29 中国科学院合肥物质科学研究院 一种用于皮肤组织荧光光谱和后向散射光光谱原位测量的深度敏感光纤探针
CN108155936B (zh) * 2018-01-03 2023-05-26 成都航天通信设备有限责任公司 一种多通道综合数据链光纤测试方法
US11672425B2 (en) 2018-02-15 2023-06-13 Speclipse, Inc. Stand-alone apparatus and methods for in vivo detection of tissue malignancy using laser spectroscopy
KR102258181B1 (ko) * 2018-02-15 2021-05-28 스페클립스 주식회사 레이저 분광 기반의 인-비보 병변 조직 검출을 위한 넌-디스크리트 스펙트럼 분석 알고리즘 및 이를 위한 방법
KR102167946B1 (ko) * 2018-02-15 2020-10-20 스페클립스 주식회사 인-비보 병변 조직 검출을 위한 레이저 분광 기반의 독립 장치 및 방법
CN108287129A (zh) * 2018-03-22 2018-07-17 中国计量大学 多通道荧光谱生物气溶胶粒子的检测装置
US11754567B2 (en) * 2018-04-30 2023-09-12 City Of Hope Cancer detection and ablation system and method
US10928309B2 (en) 2018-06-29 2021-02-23 Viavi Solutions Inc. Cross-validation based calibration of a spectroscopic model
CN110957043A (zh) * 2018-09-26 2020-04-03 金敏 疾病预测系统
US11796475B2 (en) * 2018-10-16 2023-10-24 Polyvalor, Limited Partnership Methods for performing a Raman spectroscopy measurement on a sample and Raman spectroscopy systems
FI3870957T3 (fi) * 2018-10-23 2025-09-30 Amgen Inc Spektroskooppisten mallien automaattinen kalibrointi ja automaattinen ylläpito reaaliaikaisia ennustuksia varten
CN109259718B (zh) * 2018-11-06 2021-01-12 河南科技大学第一附属医院 一种可拆分组合的内窥镜检测系统
US11913875B2 (en) 2018-12-17 2024-02-27 Evonik Operations Gmbh Method for the identification of an incorrectly calibrated or non-calibrated infrared spectrometer
CN109730694A (zh) * 2019-01-08 2019-05-10 北京信息科技大学 一种诊断人体血管内斑块类型的拉曼光谱测量探针
CN109781701A (zh) * 2019-01-18 2019-05-21 拉曼兄弟(深圳)科技发展有限公司 一种基于拉曼光谱技术的甲状旁腺术中实时检测方法
US11726034B2 (en) 2019-03-07 2023-08-15 Missouri State University IR spectra matching methods
KR102375159B1 (ko) 2019-03-22 2022-03-16 스페클립스 주식회사 레이저 유도 붕괴 스펙트럼 분석을 이용하는 진단 방법 및 이를 수행하는 진단 장치
WO2020245748A1 (en) * 2019-06-03 2020-12-10 Polyvalor, Limited Partnership Methods and systems for assessing a phenotype of a biological tissue of a patient using raman spectroscopy
JP7430778B2 (ja) 2019-08-05 2024-02-13 ジャイラス エーシーエムアイ インク ディー／ビー／エー オリンパス サージカル テクノロジーズ アメリカ レーザ療法の信号調整送達
DE112020003746T5 (de) 2019-08-05 2022-04-28 Gyrus Acmi, Inc. D/B/A Olympus Surgical Technologies America Steuerung des abstands zwischen laserfaser und ziel
WO2021034456A2 (en) * 2019-08-16 2021-02-25 Paul Bartholomew Raman spectroscopy for minerals identification
BR112022006093A2 (pt) * 2019-10-02 2022-06-21 Chemimage Corp Fusão de imageamento químico molecular com geração de imagens rgb
KR102068279B1 (ko) * 2019-10-04 2020-01-20 주식회사 루닛 이미지 분석 방법 및 시스템
JP7676374B2 (ja) * 2019-10-25 2025-05-14 アムジエン・インコーポレーテツド ラマン分光法に基づいて生物学的生成物を同定するための構成可能なハンドヘルド式生物学的分析装置
BR112022011380A2 (pt) * 2019-12-18 2022-08-23 Chemimage Corp Sistemas e métodos de combinar modalidades de imagem para detecção aprimorada de tecido
EP4096505A1 (en) * 2020-01-29 2022-12-07 King's College London Raman spectroscopy method and system
CN111281313A (zh) * 2020-03-05 2020-06-16 中国科学院长春光学精密机械与物理研究所 基于拉曼光谱的病灶在线检测系统
WO2022051741A2 (en) * 2020-08-26 2022-03-10 Baylor College Of Medicine End expandable optical fiber bundle
CN112089404B (zh) * 2020-10-10 2022-04-05 南京航空航天大学 一种内窥OCT-Raman双模成像装置及成像方法
KR102514246B1 (ko) * 2021-03-26 2023-03-27 전주대학교 산학협력단 머신러닝에 기반한 x-선 상 척추 회전각도 측정시스템 및 이를 이용한 측정방법
CN112881364B (zh) * 2021-03-29 2025-03-28 中国计量大学 一种内嵌金纳米粒子的sers微流检测器
CN113624734B (zh) * 2021-06-25 2024-08-13 港湾之星健康生物(深圳)有限公司 兼具灵敏度和响应速度的拉曼光谱检测方法与系统
US20240377315A1 (en) * 2021-10-01 2024-11-14 Trinamix Gmbh Multi single detector application specific spectrometer
GB202203993D0 (en) * 2022-03-22 2022-05-04 Keit Ltd Methods of analysing a sample and calibrating a spectrometer
CN114965425B (zh) * 2022-05-16 2024-12-03 重庆大学 基于迭代自适应加权算法的绝缘油拉曼光谱基线扣除方法和系统
EP4309568A1 (en) * 2022-07-19 2024-01-24 Canostix GmbH Method and apparatus for spectroscopic cancer screening
WO2025010030A1 (en) * 2023-07-06 2025-01-09 Agency For Science, Technology And Research Optical arrangement, device and non-invasive method for analyzing a skin sample
CN116849612B (zh) * 2023-07-07 2024-01-09 广东省新黄埔中医药联合创新研究院 一种多光谱舌象图像采集分析系统
IT202300018600A1 (it) 2023-09-11 2025-03-11 Univ Degli Studi Roma La Sapienza Dispositivo chirurgico sensorizzato e metodo di funzionamento di tale dispositivo
CN117152362B (zh) * 2023-10-27 2024-05-28 深圳市中安视达科技有限公司 内窥镜多光谱的多路成像方法、装置、设备及存储介质
KR20250117519A (ko) 2024-01-26 2025-08-05 경희대학교 산학협력단 표면증강 라만분광법 센서 및 이의 제조방법
FR3159837A1 (fr) * 2024-03-04 2025-09-05 Commissariat A L' Energie Atomique Et Aux Energies Alternatives Procédé de caractérisation d’une sonde optique
CN118211058B (zh) * 2024-05-16 2024-08-16 南京诺源医疗器械有限公司 基于拉曼光谱信号特征峰提取的数据处理方法
CN118896942B (zh) * 2024-07-23 2025-11-28 北京航空航天大学 一种体表无创肿瘤检测方法、装置及介质
CN119715494B (zh) * 2024-12-24 2025-09-16 北京合鲸科技发展有限公司 一种手持拉曼光谱仪
CN119770001B (zh) * 2025-02-20 2025-11-11 中国工程物理研究院激光聚变研究中心 基于iccd和光纤式门控的拉曼光谱系统

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5357336A (en) * 1991-08-08 1994-10-18 The Dow Chemical Company Method and apparatus for multivariate characterization of optical instrument response
US5638172A (en) * 1994-05-27 1997-06-10 Eastman Chemical Company On-line quantitative analysis of chemical compositions by raman spectrometry
JPH09145619A (ja) * 1995-09-20 1997-06-06 Kdk Corp 散乱光等の分光測定方法及び装置
US6031232A (en) * 1995-11-13 2000-02-29 Bio-Rad Laboratories, Inc. Method for the detection of malignant and premalignant stages of cervical cancer
CN1105296C (zh) * 1996-08-22 2003-04-09 伊斯曼化学公司 定量监测化学组合物的组份的方法
US5850623A (en) * 1997-03-14 1998-12-15 Eastman Chemical Company Method for standardizing raman spectrometers to obtain stable and transferable calibrations
US6351306B1 (en) * 1999-10-19 2002-02-26 Kaiser Optical Systems, Inc. Optical measurement probe calibration configurations
US6621574B1 (en) * 2000-05-25 2003-09-16 Inphotonics, Inc. Dual function safety and calibration accessory for raman and other spectroscopic sampling
JP4588324B2 (ja) * 2002-04-05 2010-12-01 マサチユセツツ・インスチチユート・オブ・テクノロジイ 組織測定用プローブ
US7647092B2 (en) * 2002-04-05 2010-01-12 Massachusetts Institute Of Technology Systems and methods for spectroscopy of biological tissue
WO2006064446A1 (en) * 2004-12-15 2006-06-22 Koninklijke Philips Electronics N.V. Calibration of optical analysis making use of multivariate optical elements
US7583378B2 (en) * 2006-02-23 2009-09-01 Itt Manufacturing Enterprises, Inc. Spectrograph calibration using known light source and Raman scattering
CN103278491B (zh) * 2009-11-25 2017-07-07 欧普图斯(苏州)光学纳米科技有限公司 用基于纳米结构的光谱检测方法检测化学物和生化物杂质
CN102725624A (zh) * 2009-12-17 2012-10-10 不列颠哥伦比亚癌症分社 用于通过拉曼光谱进行的体内组织表征的设备和方法
CN102297856B (zh) * 2010-06-25 2015-09-30 清华大学 用于自动校准拉曼光谱检测系统的方法及拉曼光谱检测系统
DE102011077564B4 (de) 2011-06-15 2016-08-25 Sirona Dental Systems Gmbh Verfahren zur optischen dreidimensionalen Vermessung eines dentalen Objekts

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11699102B2 (en) 2017-02-28 2023-07-11 Verily Life Sciences Llc System and method for multiclass classification of images using a programmable light source
US12433488B2 (en) 2018-01-17 2025-10-07 14336186 Canada Corp. (Exclaro) System and methods for real time raman spectroscopy for cancer detection

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