SG11201408793XA - Methods related to real-time cancer diagnostics at endoscopy utilizing fiber-optic raman spectroscopy - Google Patents

Methods related to real-time cancer diagnostics at endoscopy utilizing fiber-optic raman spectroscopy

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Publication number
SG11201408793XA
SG11201408793XA SG11201408793XA SG11201408793XA SG11201408793XA SG 11201408793X A SG11201408793X A SG 11201408793XA SG 11201408793X A SG11201408793X A SG 11201408793XA SG 11201408793X A SG11201408793X A SG 11201408793XA SG 11201408793X A SG11201408793X A SG 11201408793XA
Authority
SG
Singapore
Prior art keywords
singapore
department
national university
international
ridge road
Prior art date
Application number
SG11201408793XA
Inventor
Zhiwei Huang
Khek Yu Ho
Mads Sylvest Bergholt
Wei Zheng
Khay Guan Yeoh
Shiyamala Duraipandian
Original Assignee
Univ Singapore
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Application filed by Univ Singapore filed Critical Univ Singapore
Publication of SG11201408793XA publication Critical patent/SG11201408793XA/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00163—Optical arrangements
    • A61B1/00165—Optical arrangements with light-conductive means, e.g. fibre optics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
    • G01N21/274—Calibration, base line adjustment, drift correction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/02—Operational features
    • A61B2560/0223—Operational features of calibration, e.g. protocols for calibrating sensors
    • A61B2560/0228—Operational features of calibration, e.g. protocols for calibrating sensors using calibration standards
    • A61B2560/0233—Optical standards
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G01J2003/4424—Fluorescence correction for Raman spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N2021/653—Coherent methods [CARS]
    • G01N2021/656—Raman microprobe
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/08—Optical fibres; light guides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/12—Circuits of general importance; Signal processing
    • G01N2201/127—Calibration; base line adjustment; drift compensation
    • G01N2201/12746—Calibration values determination
    • G01N2201/12753—Calibration values determination and storage
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/12—Circuits of general importance; Signal processing
    • G01N2201/129—Using chemometrical methods

Abstract

(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 9 January 2014 (09.01.2014) WIPOIPCT (10) International Publication Number WO 2014/007759 A1 (51) International Patent Classification: G01N21/65 (2006.01) A61B 6/00 (2006.01) A61B 5/00 (2006.01) G01N33/574 (2006.01) G01J3/44 (2006.01) (21) International Application Number: PCT/SG2013/000273 (22) International Filing Date: 2 July 2013 (02.07.2013) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 61/667,384 2 July 2012 (02.07.2012) US 1307338.2 23 April 2013 (23.04.2013) GB (71) Applicant: NATIONAL UNIVERSITY OF SINGA­ PORE [SG/SG]; 21 Lower Kent Ridge Road, Singapore 119077 (SG). (72) Inventors: HUANG, Zhiwei; c/o National University of Singapore, Faculty of Engineering, Department of Bioen- gineering, 21 Lower Kent Ridge Road, Singapore 119077 (SG). HO, Khek Yu; c/o National University of Singapore, Yong Loo Lin School of Medicine, Department of Medi­ cine, 21 Lower Kent Ridge Road, Singapore 119077 (SG). BERGHOLT, Mads Sylvest; c/o National University of Singapore, Faculty of Engineering, Department of Bioen- gineering, 21 Lower Kent Ridge Road, Singapore 119077 (SG). ZHENG, Wei; c/o National University of Singapore, Faculty of Engineering, Department of Bioengineering, 21 Lower Kent Ridge Road, Singapore 119077 (SG). YEOH, Khay Guan; c/o National University of Singapore, Yong Loo Lin School of Medicine, Department of Medicine, 21 Lower Kent Ridge Road, Singapore 119077 (SG). DURAIPANDIAN, Shiyamala; c/o National University of Singapore, Faculty of Engineering, Department of Bioen­ gineering, 21 Lower Kent Ridge Road, Singapore 119077 (SG). (74) Agent: AMICA LAW LLC; 30 Raffles Place, #18-03/04 Chevron House, Singapore 048622 (SG). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. [Continued on next page] (54) Title: METHODS RELATED TO REAL-TIME CANCER DIAGNOSTICS AT ENDOSCOPY UTILIZING FIBER-OPTIC RAMAN SPECTROSCOPY (57) Abstract: A method of achieving instrument inde­ pendent measurements for quantitative analysis of fiber­ optic Raman spectroscope system, the system compris­ ing laser source, spectroscope and a a a fiber optic probe to transmit light from the laser source to a target and re­ turn scattered light to the spectroscope, the method com­ prising transmitting light from the laser source to a standard target having a known spectrum, recording a calibration spectrum of the scattered light from the standard target, comparing the known spectrum and the calibration system and generating a probe and/or probe- system transfer function, and storing the transfer func­ tion. Further provided is a method of performing real­ time diagnostic Raman spectroscopy optionally in com­ bination with the other disclosed methods. 0\ i> i> o o [HuHnraaikm Distal tip of endoscope .L Epitfteflum Stroma WO 2014/007759 A11II llll IIII III III III llll III III Hill Hill II lllll llll 111 mill llll 111 llll (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17 (iv)) Published: — with international search report (Art. 21(3))
SG11201408793XA 2012-07-02 2013-07-02 Methods related to real-time cancer diagnostics at endoscopy utilizing fiber-optic raman spectroscopy SG11201408793XA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261667384P 2012-07-02 2012-07-02
GB1307338.2A GB2513343A (en) 2013-04-23 2013-04-23 Methods related to instrument-independent measurements for quantitative analysis of fiber-optic Raman spectroscopy
PCT/SG2013/000273 WO2014007759A1 (en) 2012-07-02 2013-07-02 Methods related to real-time cancer diagnostics at endoscopy utilizing fiber-optic raman spectroscopy

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SG11201408793XA true SG11201408793XA (en) 2015-01-29

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US (1) US9931039B2 (en)
EP (1) EP2870462B1 (en)
JP (1) JP6230077B2 (en)
KR (1) KR101947859B1 (en)
CN (1) CN104541153B (en)
CA (1) CA2917308C (en)
ES (1) ES2930428T3 (en)
GB (1) GB2513343A (en)
SG (1) SG11201408793XA (en)
WO (1) WO2014007759A1 (en)

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JP2015526135A (en) 2015-09-10
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