CN106691549A - Puncture biopsy needle with optical fiber probes - Google Patents
Puncture biopsy needle with optical fiber probes Download PDFInfo
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- CN106691549A CN106691549A CN201510495347.2A CN201510495347A CN106691549A CN 106691549 A CN106691549 A CN 106691549A CN 201510495347 A CN201510495347 A CN 201510495347A CN 106691549 A CN106691549 A CN 106691549A
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- optical fiber
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- biopsy needle
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Abstract
The invention relates to the field of medical equipment and oncology, and relates to a puncture biopsy needle with optical fiber probes. The puncture biopsy needle with optical fiber probes mainly comprises a host machine, a puncture needle, optical fiber probes and a display device, wherein the optical fiber probes are arranged on the outer edge of a needle core of the puncture biopsy needle. According to the puncture biopsy needle, the optical fiber probes are adopted to transmit lasers to the tip of the puncture biopsy needle, and therefore the real-time acquisition of Raman spectrum signals of pinpoint contact tissues or cells is achieved, and the signals are automatically analyzed and monitored. When the puncture biopsy needle is used, the Raman spectrum of the pinpoint tissues and cells can be monitored in real time in punctures, and by acquiring information of cancerous status and the like of the current needle tip contact tissues and cells through analyzing spectrum signals, tumors can be identified from normal tissues in real time in punctures, which helps doctors to find out cancerous tissues through biopsy more precisely, therefore the positive rate of biopsy is increased, complications caused by vascular injury and other normal tissue injuries are avoided, and the safety of punctures is improved.
Description
Technical field
The present invention relates to medicine equipment and oncology.It is related to a kind of new medical puncture biopsy needle, and in particular to a kind of puncture biopsy needle with optical fiber probe.The present invention adds the design of Raman fiber probe on the basis of original puncture biopsy needle, can be by the difference Intelligent Recognition tumor tissues and normal structure of real-time detection Raman spectrum；It is further useful for quick diagnosis innocent and malignant tumour.
Background technology
Prior art discloses the premise that oncological pathology diagnosis is oncotherapy.Aspiration biopsy is the main path for obtaining histopathology sample.Although the characteristics of usual aspiration biopsy has quick, easy, accurate, safe, economic, but due to lesion present position and its heterogeneity of structure, so that clinically the accuracy of aspiration biopsy materials and the security of puncture are affected, very hang-up is brought to clinical treatment.Clinical practice shows, current various puncture biopsy needles are still unable to Real time identification tumor tissues and normal structure, only by the experience of doctor, it is more difficult to precisely distinguish the boundary of tumor tissues and normal structure, therefore biopsy accuracy is govern, generally requiring multiple biopsy could be made a definite diagnosis.
Since the nineties, as the development of laser technology and the application of new detector technology are gradually ripe, the application of Raman spectroscopy is more and more extensive；Including tumor tissues it is by protein with regard to its basic chemical composition due to human organ tissue, nucleic acid, the biomolecule such as lipid and carbohydrate is constituted, and the molecule of different structure has different Raman spectral characteristics, thus different materials can be identified and distinguished between from the Raman signatures spectrum of material.According to the difference in the composition and molecular conformation of each composition in tumor tissues and normal structure so that the difference of raman scattering spectrum is captured by clinical fiber Raman spectral technique, internal Real time identification malignant tumour is used directly in and is possibly realized with normal structure.In recent years, studies have found that genetic algorithm is applied in Raman spectrum analysis, live body can be done to early stage cancerous tissue and is quickly recognized；The raman bandses that researcher's analysis identification cervical cancer tissues are obtained early diagnose the degree of accuracy 82.9% to cancer（Sensitivity 72.5% (29/40), specificity 89.2% (58/65)）”.Fiber Raman spectrum can provide the molecular structure information of tissue samples as a kind of optical technology；P. Crow etc. analyzes 29 220 Raman spectrums of frost carcinoma of urinary bladder sample, as a result shows that Fiber optic near infrared spectroscopy Raman spectrum can be used for the in-vitro diagnosis of TCCB.
Present situation based on prior art, present inventor intends providing the intelligent puncture needle of a kind of energy Real time identification cancerous issue and normal structure, improves the precision of aspiration biopsy as far as possible to reach, and further helps in quick diagnosis innocent and malignant tumour.
The content of the invention
It is an object of the invention to provide a kind of New Energy identification tumor tissues and the intelligent puncture biopsy needle of cell；Specifically related to a kind of puncture biopsy needle with optical fiber probe.
It is another object of the present invention to application, the intelligent puncture biopsy needle is used for Real time identification cancerous issue and normal structure in art, improves aspiration biopsy accuracy rate, further helps in quick diagnosis innocent and malignant tumour.
To reach above-mentioned purpose, the present invention uses following technical proposals：
A kind of puncture biopsy needle with optical fiber probe, it is main including control release laser and capture, the main frame for analyzing Raman spectrum, the puncture needle of trocar inner side profile fiber probe and the acoustic control touch screen display device with different colours signal lamp and audio prompting function；Connect LASER Light Source and spectroanalysis instrument in the optical fiber probe rear end, the raman spectral signal of puncture needle inner fibers probe tip position undertissue can be obtained, be used to recognize needle tip organize in one's power whether canceration, and with prompting function in a variety of forms.
More specifically, a kind of puncture needle with optical fiber probe of the invention, it is characterised in that it is mainly by main frame（1）, puncture needle（2）, optical fiber probe（3）Display（4）Composition, the optical fiber probe（3）It is arranged in puncture needle（2）The lateral border of nook closing member.
In the present invention, the puncture needle includes：The device that puncture biopsy needle, insertion puncture needle, lumbar puncture needle etc. are diagnosed or treated by puncture, in one embodiment of the present of invention, preferably puncture needle is puncture biopsy needle.
In the present invention, the main frame（1）It is the intelligent equipment for controlling laser release and spectrum capture and analytic function.
In the present invention, the optical fiber probe（3）It is made up of taper nano optical fibers probe, its end may be coupled to releasable laser and capture and analyze the main frame of Raman spectrum.
In the present invention, the optical fiber probe（3）Can be also made up of section nano optical fibers probe, its end may be coupled to releasable laser and capture and analyze the main frame of Raman spectrum.
In the present invention, the display（4）Be a kind of touch screen type have can be while being aided with reddish yellow green color signal lamp and audio prompting function.
In the present invention, the display（4）It is a kind of touch-sensitive display, in one embodiment of the present of invention, preferably touch-sensitive display adds red, yellow and green indicator lamp, and it represents tumor tissues, precancerous lesion and normal structure respectively；In one embodiment of the present of invention, further preferably touch-sensitive display supplemental audio prompting function.
The present invention is directed to the relatively low defect of one-time puncture biopsy success rate caused by prior art often cannot voluntarily recognize tumor tissues and normal structure with puncture biopsy needle, there is provided a kind of novel puncture biopsy pin with optical fiber probe, its trocar inner side is placed with optical fiber probe, laser signal can be conducted by optical fiber to the tissue of needle tip, tissue to current location carries out real-time monitoring and the capture of Raman spectrum, by cancerous issue and the Raman spectrum difference of normal structure, Real time identification cancerous issue and normal structure, it is easy to ensure accurately to get tumor tissues in art；The features such as puncture needle also has simple, easy to operate, easy to use and safe and reliable.
It is of the invention compared with traditional puncture needle, with following obvious prominent substantive distinguishing features and remarkable advantage：
1.
Intelligent puncture needle application optical fiber of the invention is sophisticated to puncture needle by Laser Transmission, so as to the collection to the tissue Raman spectral signal at needle tip, by computer calculate and and different tissues Raman spectrum data storehouse compare analyze judged in 3 seconds current organization whether canceration, so as to contribute to the position of cancerous issue in surgeon's real-time judge puncture process；By analyzing the cancerous state to judge current organization of contrast raman spectral signal and being shown in touch display screen, can respectively with red, yellow and green indicating lamp prompting malignant tissue, precancerous lesion and normal structure, it is aided with sound prompt function simultaneously, reminds the accurate biopsy cancerous issue of doctor.
2. novel intelligent puncture needle of the invention overcomes the deficiency of current conventional puncture needle None- identified tumor tissues and normal structure；The experience that doctor can thoroughly be changed by the preoperative imageological examination of tumor patient and individual is judged, and can not only help doctor precisely to obtain cancerous issue, can also reduce complication after puncture.
3. novel intelligent puncture needle of the invention is by real-time Raman spectrum analysis, the diagnostic function with replacement cytologic slide.
Brief description of the drawings
Fig. 1 is the schematic device of the intelligent puncture needle that taper nano optical fibers probe is combined in embodiments of the invention.
Specific embodiment
The preferred embodiments of the present invention combination detailed description is as follows：
Embodiment
1
As shown in figure 1, of the invention can recognize that tumor tissues and the intelligent puncture needle of cell include the main frame 1 and puncture needle 2 of control analysis Raman spectrum, taper nano optical fibers probe 3 and display 4, the optical fiber probe are added on this basis（3）It is arranged in puncture needle（2）The lateral border of nook closing member.
In the present embodiment, puncture needle is puncture biopsy needle, main frame（1）It is the intelligent equipment for controlling laser release and spectrum capture and analytic function；Optical fiber probe（3）It is made up of taper nano optical fibers probe, its end may be coupled to releasable laser and capture and analyze the main frame of Raman spectrum；The display（4）It is a kind of touch-sensitive display, red, yellow and green indicator lamp can be added, it represents tumor tissues, precancerous lesion and normal structure respectively；Can also supplemental audio prompting function；
The tip size of conical fiber probe described in the present embodiment 3 can reach 100 nanoscales, and it is distributed in puncture needle nook closing member tip outer rim, and the wherein terminal of optical fiber 3 can connect main frame 1 and display 4 with laser spectral analysis instrument function；When clinical implementation is punctured, the LASER Light Source of 633nm etc. is connected to using conical fiber 3, after connection light source, when puncture needle touches pathologic tissue areas, first pass through the raman spectral signal that the tissue that laser gets to puncture needle tip is obtained optical fiber current location, by analyzing the cancerous state of the judgement current organization of contrast raman spectral signal and being shown in touch display screen, can respectively by red, yellow and green indicating lamp prompting malignant tissue, precancerous lesion and normal structure, it is aided with sound prompt function simultaneously, reminding doctor carries out accurate biopsy cancerous issue, so as to improve the rate of correct diagnosis of cancerous issue.
Claims (10)
1. a kind of puncture biopsy needle with optical fiber probe, it is characterised in that the puncture biopsy needle it is main by：Main frame（1）, puncture needle（2）, optical fiber probe（3）Display（4）Composition, the optical fiber probe（3）It is arranged in puncture needle（2）The lateral border of nook closing member.
2. the puncture biopsy needle with optical fiber probe according to claim 1, it is characterised in that the puncture needle is selected from puncture biopsy needle, insertion puncture needle or lumbar puncture needle.
3. the puncture biopsy needle with optical fiber probe according to claim 1, it is characterised in that the main frame（1）It is the type intelligent apparatus for controlling laser release and spectrum capture and analytic function.
4. the puncture biopsy needle with optical fiber probe according to claim 2, it is characterised in that the puncture needle is puncture biopsy needle.
5. the puncture biopsy needle with optical fiber probe according to claim 1, it is characterised in that the optical fiber probe（3）It is made up of taper nano optical fibers probe, its end is connected to releasable laser and captures and analyze the main frame of Raman spectrum.
6. the puncture biopsy needle with optical fiber probe according to claim 1, it is characterised in that the optical fiber probe（3）It is made up of section nano optical fibers probe, its end is connected to releasable laser and captures and analyze the main frame of Raman spectrum.
7. the puncture biopsy needle with optical fiber probe according to claim 1, it is characterised in that the display（4）Be a kind of touch screen type have can be while being aided with reddish yellow green color signal lamp and audio prompting function.
8. the puncture biopsy needle with optical fiber probe according to claim 1, it is characterised in that the display（4）It is a kind of touch-sensitive display.
9. the puncture biopsy needle with optical fiber probe according to claim 8, it is characterised in that the touch-sensitive display sets up red, the yellow and green indicator lamp for representing tumor tissues, precancerous lesion and normal structure respectively.
10. the puncture biopsy needle with optical fiber probe according to claim 8, it is characterised in that the touch-sensitive display sets up audio alert function.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510495347.2A CN106691549A (en) | 2015-08-13 | 2015-08-13 | Puncture biopsy needle with optical fiber probes |
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| CN201510495347.2A CN106691549A (en) | 2015-08-13 | 2015-08-13 | Puncture biopsy needle with optical fiber probes |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107684441A (en) * | 2017-09-29 | 2018-02-13 | 黄志伟 | A kind of Raman microprobe device with fine needle aspiration biopsy's function |
| CN109394255A (en) * | 2018-12-14 | 2019-03-01 | 邱军 | A kind of intelligence hepatopathy check device |
| CN110916728A (en) * | 2019-12-10 | 2020-03-27 | 武汉大学中南医院 | Puncture biopsy method and device based on optical fiber transmission type fluorescence life guidance |
| CN111728674A (en) * | 2020-06-11 | 2020-10-02 | 武汉理工大学 | Optical fiber probe human tissue information online monitoring system based on Raman scattering |
| CN114601506A (en) * | 2022-03-30 | 2022-06-10 | 北京中研智创新技术研究院有限公司 | Brain tissue detection system based on artificial intelligence recognition and Raman spectrum |
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| CN104107069A (en) * | 2013-04-16 | 2014-10-22 | 南方医科大学南方医院 | Ultrasonic microscopic examination system for mediastinal lesions |
| CN104321018A (en) * | 2012-05-22 | 2015-01-28 | 皇家飞利浦有限公司 | Ultrasound image display set-up for remote display terminal |
| CN104541153A (en) * | 2012-07-02 | 2015-04-22 | 新加坡国立大学 | Methods related to real-time cancer diagnostics at endoscopy utilizing fiber-optic raman spectroscopy |
| CN204909588U (en) * | 2015-08-13 | 2015-12-30 | 复旦大学附属肿瘤医院 | Aspiration biopsy needle with optical fiber probe |
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2015
- 2015-08-13 CN CN201510495347.2A patent/CN106691549A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104321018A (en) * | 2012-05-22 | 2015-01-28 | 皇家飞利浦有限公司 | Ultrasound image display set-up for remote display terminal |
| CN104541153A (en) * | 2012-07-02 | 2015-04-22 | 新加坡国立大学 | Methods related to real-time cancer diagnostics at endoscopy utilizing fiber-optic raman spectroscopy |
| CN104107069A (en) * | 2013-04-16 | 2014-10-22 | 南方医科大学南方医院 | Ultrasonic microscopic examination system for mediastinal lesions |
| CN204909588U (en) * | 2015-08-13 | 2015-12-30 | 复旦大学附属肿瘤医院 | Aspiration biopsy needle with optical fiber probe |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107684441A (en) * | 2017-09-29 | 2018-02-13 | 黄志伟 | A kind of Raman microprobe device with fine needle aspiration biopsy's function |
| CN109394255A (en) * | 2018-12-14 | 2019-03-01 | 邱军 | A kind of intelligence hepatopathy check device |
| CN109394255B (en) * | 2018-12-14 | 2019-09-03 | 邱军 | A kind of intelligence hepatopathy check device |
| CN110916728A (en) * | 2019-12-10 | 2020-03-27 | 武汉大学中南医院 | Puncture biopsy method and device based on optical fiber transmission type fluorescence life guidance |
| CN111728674A (en) * | 2020-06-11 | 2020-10-02 | 武汉理工大学 | Optical fiber probe human tissue information online monitoring system based on Raman scattering |
| CN114601506A (en) * | 2022-03-30 | 2022-06-10 | 北京中研智创新技术研究院有限公司 | Brain tissue detection system based on artificial intelligence recognition and Raman spectrum |
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Application publication date: 20170524 |