CN106923781A - A kind of Raman Gastroscope Diagnosis instrument - Google Patents
A kind of Raman Gastroscope Diagnosis instrument Download PDFInfo
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- CN106923781A CN106923781A CN201710193247.3A CN201710193247A CN106923781A CN 106923781 A CN106923781 A CN 106923781A CN 201710193247 A CN201710193247 A CN 201710193247A CN 106923781 A CN106923781 A CN 106923781A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/273—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the upper alimentary canal, e.g. oesophagoscopes, gastroscopes
- A61B1/2736—Gastroscopes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00002—Operational features of endoscopes
- A61B1/00011—Operational features of endoscopes characterised by signal transmission
- A61B1/00013—Operational features of endoscopes characterised by signal transmission using optical means
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00002—Operational features of endoscopes
- A61B1/00043—Operational features of endoscopes provided with output arrangements
- A61B1/00045—Display arrangement
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00112—Connection or coupling means
- A61B1/00117—Optical cables in or with an endoscope
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00131—Accessories for endoscopes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00163—Optical arrangements
- A61B1/00165—Optical arrangements with light-conductive means, e.g. fibre optics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
- A61B1/05—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances characterised by the image sensor, e.g. camera, being in the distal end portion
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
- A61B1/0661—Endoscope light sources
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Abstract
The invention discloses a kind of Raman Gastroscope Diagnosis instrument, including gastroscope imaging system and Raman Imaging System；Gastroscope imaging system includes light source and soft endoscope, and soft endoscope gathers image by the brightness of light source in stomach；Raman Imaging System is obtained in that the Raman spectrum of gastric tissue.During gastrocopy, whether the image in gastroscope imaging system collection stomach judges there is suspicious lesion in stomach according to image；Then suspicious lesions are detected by Raman Imaging System, the laser that laser sends passes to probe by Transmission Fibers, it is irradiated to and Raman signal is inspired at suspicious lesions, probe collection Raman signal simultaneously passes to spectroanalysis instrument, obtain Raman spectrum, Raman spectrum is corresponded with molecular structure, to having done the other detection of molecular level at suspicious lesions, can immediately arrive at the diagnostic result organized herein and whether lesion occurs.The Raman Gastroscope Diagnosis instrument realizes real-time, noninvasive, accurately Molecular pathological diagnosis while gastrocopy.
Description
Technical field
The present invention relates to technical field of medical instruments, in particular it relates to a kind of Raman Gastroscope Diagnosis instrument.
Background technology
Stomach cancer is one of common fatal disease of the mankind, is one of most common malignant tumour in the world today, especially
It is in East Asia Region.If early detection stomach cancer in gastroscopy procedures, you can significantly improve the survival rate of such crowd.
But, the gastroscope that current diagnosing gastric cancer is used is a kind of white light reflection endoscope system, largely can only be according to
Rely the vision in the mankind to be judged, and the structure change of tissue can only be observed, tissue occurs obvious
It is just distinguishable during change.Even the extremely abundant doctor of experience, depend merely on this technology of white light reflection endoscope system and judged,
The rate of precision of diagnosis is very low.
In order to improve the rate of precision of diagnosis, a kind of improved diagnostic method is pathological biopsy art, in the guiding of traditional gastroscope
Under, suspect tissue is cut off, delivering to pathology department carries out pathologic finding, by the processing routine of a series of complex, after general five days,
Final medical certificate can be taken.
The pathological biopsy method of this surgery excision formula has invasion, and time-consuming, laborious, and is unsuitable for high-risk
The gastric cancer screening of crowd, the patient that especially there is multiple lesion to stomach.
The content of the invention
It is an object of the invention to provide a kind of Raman Gastroscope Diagnosis instrument, the Raman Gastroscope Diagnosis instrument is while gastrocopy
Realize real-time, noninvasive, accurately Molecular pathological diagnosis.
In order to realize above-mentioned technical purpose, the invention provides a kind of Raman Gastroscope Diagnosis instrument, including gastroscope imaging system
And Raman Imaging System；
The gastroscope imaging system includes light source and soft endoscope, and the soft endoscope is by the brightness of the light source in stomach
Interior collection image；
The Raman Imaging System includes laser, probe, spectroanalysis instrument, Transmission Fibers；The laser is by the biography
Fibre is lost by laser transfer to the probe, Raman signal is inspired on gastric tissue so that the probe is irradiated to laser, institute
State Raman signal described in probe collection and pass to the spectroanalysis instrument, the spectroanalysis instrument pair by the Transmission Fibers
The Raman signal carries out the Raman spectrum that spectrum analysis obtains the gastric tissue；
The camera lens of the soft endoscope for being additionally provided with the gastroscope imaging system of popping one's head in, the soft endoscope and described
Transmission Fibers are in same flexible duct.
Optionally, the probe includes projecting light path and collects light path；The laser is irradiated to by the projecting light path
On the gastric tissue, the collection light path is collected the Raman signal for inspiring and passes to the spectroanalysis instrument.
Optionally, the projecting light path includes the first lens, the second lens and bandpass filter, and the laser is by described
First lens turn into directional light, the directional light by second lens focus to the gastric tissue, the bandpass filter
Piece is located between first lens and second lens.
Optionally, the collection light path includes collecting lens and pass filter long, and the Raman signal for inspiring first leads to
The pass filter long is crossed, then the Transmission Fibers is collected into through the collecting lens.
Optionally, the laser is 532nm semiconductor lasers or 785nm semiconductor lasers.
Optionally, bandwidth is provided with the laser and suppresses chip so that output bandwidth is less than 0.1nm.
Optionally, also including display, the soft endoscope is displayed in by the image in the probe collection stomach
On the display.
Optionally, the Raman spectrum of the spectroanalysis instrument output of the Raman Imaging System is through software analysis
Afterwards, show on the display.
The Raman Gastroscope Diagnosis instrument that the present invention is provided, including gastroscope imaging system and Raman Imaging System；Gastroscope imaging system
System includes light source and soft endoscope, and soft endoscope gathers image by the brightness of light source in stomach；Raman Imaging System bag
Include laser, probe, spectroanalysis instrument, Transmission Fibers；Laser transfer is given probe by laser by Transmission Fibers, to pop one's head in
It is irradiated to laser and Raman signal is inspired on gastric tissue, probe collection Raman signal simultaneously passes to spectrum point by Transmission Fibers
Analyzer, spectroanalysis instrument carries out the Raman spectrum that spectrum analysis obtains gastric tissue to Raman signal；Probe is additionally provided with gastroscope imaging
The camera lens of the soft endoscope of system, soft endoscope and Transmission Fibers are located in same flexible duct.
During gastrocopy, probe together enters in patient's body together with flexible duct, the figure in gastroscope imaging system collection stomach
Whether picture, judges there is suspicious lesion in stomach according to image；Then suspicious lesions are detected by Raman Imaging System, is swashed
The laser that light device sends passes to probe by Transmission Fibers, is irradiated to and Raman signal is inspired at suspicious lesions, probe collection
Raman signal simultaneously passes to spectroanalysis instrument, obtains Raman spectrum, and Raman spectrum is corresponded with molecular structure, to suspicious lesions
The other detection of molecular level has been done at place, can immediately arrive at the diagnostic result organized herein and whether lesion occurs.The Raman gastroscope is examined
Disconnected instrument realizes real-time, noninvasive, accurately Molecular pathological diagnosis while gastrocopy.
Brief description of the drawings
Accompanying drawing is, for providing a further understanding of the present invention, and to constitute the part of specification, with following tool
Body implementation method is used to explain the present invention together, but is not construed as limiting the invention.
Fig. 1 is a kind of structural representation of specific embodiment of Raman Gastroscope Diagnosis instrument provided by the present invention；
Wherein, the corresponding relation between the reference and component names in Fig. 1 is as follows：
Laser 1；Collector lens 2；Transmission Fibers 3；Probe 4；Sample 5；
Spectroanalysis instrument 6；Display 7；Soft endoscope 8；Camera lens 9.
Specific embodiment
Specific embodiment of the invention is described in detail below in conjunction with accompanying drawing.It should be appreciated that this place is retouched
The specific embodiment stated is merely to illustrate and explain the present invention, and is not intended to limit the invention.
Fig. 1 is refer to, Fig. 1 is a kind of structural representation of specific embodiment of Raman Gastroscope Diagnosis instrument provided by the present invention
Figure.
In a kind of specific embodiment, the invention provides a kind of Raman Gastroscope Diagnosis instrument, including gastroscope imaging system
And Raman Imaging System；Gastroscope imaging system includes light source and soft endoscope 8, and soft endoscope 8 exists by the brightness of light source
Collection image in stomach；Raman Imaging System includes laser 1, probe 4, spectroanalysis instrument 6, Transmission Fibers 3；Laser 1 passes through
Laser transfer to probe 4,4 is irradiated to laser to inspire Raman signal on gastric tissue, probe 4 by Transmission Fibers 3 to pop one's head in
Collect Raman signal and pass to spectroanalysis instrument 6 by Transmission Fibers 3, spectroanalysis instrument 6 carries out spectrum point to Raman signal
Analysis obtains the Raman spectrum of gastric tissue；Probe 4 is additionally provided with the camera lens 9 of the soft endoscope 8 of gastroscope imaging system, soft endoscope
8 and Transmission Fibers 3 in the same flexible duct.
During gastrocopy, probe 4 together enters in patient's body together with flexible duct, the figure in gastroscope imaging system collection stomach
Whether picture, judges there is suspicious lesion in stomach according to image；Then suspicious lesions are detected by Raman Imaging System, is swashed
The laser that light device 1 sends passes to probe 4 by Transmission Fibers 3, is irradiated to and Raman signal is inspired at suspicious lesions, probe 4
Collect Raman signal and simultaneously pass to spectroanalysis instrument 6, obtain Raman spectrum, Raman spectrum is corresponded with molecular structure, pair can
Doubtful lesion has done the other detection of molecular level, can immediately arrive at the diagnostic result organized herein and whether lesion occurs.
Probe 4 is provided with the camera lens 9 of soft endoscope 8, can carry out gastrocopy, meanwhile, the probe 4 can also transmit sharp
Light and collection Raman signal, carry out Raman detection, and Raman detection utilizes Raman spectrum, can accomplish dividing for molecular pathology aspect
Analysis, detection speed is fast, can replace pathological analysis.
Then the Raman Gastroscope Diagnosis instrument is directly used in Raman spectrum using the suspicious lesions in gastroscope imaging positioning stomach
Sight glass technology carries out real-time assessment.According to tissue biological's intramolecular intrinsic Raman signal change, carry out can for guiding doctor
The biopsy of mucosal tissue is doubted, quick and clear and definite identification is lesion in stomach.The Raman Gastroscope Diagnosis instrument is in the same of gastrocopy
Shi Shixian is real-time, noninvasive, accurately Molecular pathological diagnosis.
In further specific embodiment, probe 4 includes projecting light path and collects light path；Laser is shone by projecting light path
It is mapped on gastric tissue, collection light path is collected the Raman signal for inspiring and passes to spectroanalysis instrument 6.
The probe 4 includes two sets of light paths, and a set of light path guiding laser is irradiated on gastric tissue 5, is irradiated on gastric tissue 5
After inspire Raman signal, another set of light path collects the Raman signal for inspiring, and passes to spectroanalysis instrument 6 and carry out spectrum point
Analysis.Probe 4 had both realized the projection of laser, and the collection of Raman signal is realized again.
Probe 4 is connected with laser 1 and spectroanalysis instrument 6 respectively by two Transmission Fibers 3, the biography of connecting laser 1
Lose fine 3 to be connected with projecting light path, the Transmission Fibers 3 for connecting spectroanalysis instrument 6 are connected with light path is collected.
It is a kind of preferred embodiment in, projecting light path include the first lens, the second lens and bandpass filter, laser warp
The first lens are crossed as directional light, directional light is by the second lens focus to gastric tissue, bandpass filter is located at the first lens
And second between lens.
The laser passed over by Transmission Fibers 3 is focused on gastric tissue by the first lens and the second lens, is irradiated
By the process for focusing on again when on to gastric tissue, the energy of laser is all converged in focus, and shone directly into stomach group
Knit and compare, enhance the intensity of laser, the effect of irradiation is more preferable.Bandpass filter, helps to import exciting light, anti-stop signal
Light is returned.
In another preferred embodiment, collecting light path includes collecting lens and pass filter long, the Raman for inspiring
Signal first passes through pass filter long, is then collected into Transmission Fibers 3 through collecting lens.
The Raman signal for inspiring needs to be analyzed, and can be collected by probe 4, is then passed to spectrum analysis
Instrument 6 carries out spectrum analysis, collects the collecting lens in light path, can collect Raman signal in Transmission Fibers 3, and by transmission
Optical fiber 3 passes to spectroanalysis instrument 6.While collecting Raman signal by collecting lens, veiling glare can also be effectively shielded,
Increase the signal to noise ratio of Raman signal.Pass filter long can stop that exciting light will not be returned, it is ensured that flashlight passes through.
In above-mentioned each specific embodiment, laser 1 is 532nm semiconductor lasers or 785nm semiconductor lasers
Device.
Using the laser of 532nm, the laser of 532nm has good resonant check to imitate for the Raman signal of biological tissue
Should, the degree of accuracy of test can be increased.Furthermore it is also possible to using the laser of 785nm or other near-infrared wavelengths.
In further specific embodiment, bandwidth is provided with laser 1 and suppresses chip so that output bandwidth is less than
0.1nm。
Bandwidth suppression technology is employed inside laser 1, output bandwidth can be made very narrow, reach 0.05nm, be much better than biography
The 0.1nm of system, so as to improve Raman signal intensity, increases the accuracy and accuracy for judging.
In another specific embodiment, also including display 7, soft endoscope 8 gathers the figure in stomach by probe 4
Picture, and show on the display 7.
Soft endoscope 8 is by the image in the stomach of the collection of probe 4 by that can be directly displayed at display after image procossing
On device 7, doctor determines whether suspicious lesions by observation, such as suspects that there are suspicious lesions, changeable use Raman image in somewhere
System carries out real-time assessment, and whether identification there occurs lesion, draw diagnostic result herein.
Further, after the Raman spectrum of the output of spectroanalysis instrument 6 of Raman Imaging System is through software analysis, it is displayed in aobvious
Show on device 7.
Every kind of tissue has a Raman spectrum of oneself, the Raman signal of Raman Imaging System collection by after spectrum analysis,
Compared with each Raman spectrum, determine that the tissue is normal tissue or pathological tissues.The process of comparison analysis can pass through
Software in main frame is realized, while the analysis process can be presented on the display 7, and by display 7 directly give whether
It is the signal of normal structure.
It is understood that the embodiment of above principle being intended to be merely illustrative of the present and the exemplary implementation for using
Mode, but the invention is not limited in this.For those skilled in the art, essence of the invention is not being departed from
In the case of god and essence, various changes and modifications can be made therein, and these variations and modifications are also considered as protection scope of the present invention.
Claims (8)
1. a kind of Raman Gastroscope Diagnosis instrument, it is characterised in that including gastroscope imaging system and Raman Imaging System；
The gastroscope imaging system includes light source and soft endoscope, and the soft endoscope is by the brightness of the light source in stomach
Interior collection image；
The Raman Imaging System includes laser, probe, spectroanalysis instrument, Transmission Fibers；The laser is by the biography
Fibre is lost by laser transfer to the probe, Raman signal is inspired on gastric tissue so that the probe is irradiated to laser, institute
State Raman signal described in probe collection and pass to the spectroanalysis instrument, the spectroanalysis instrument pair by the Transmission Fibers
The Raman signal carries out the Raman spectrum that spectrum analysis obtains the gastric tissue；
The camera lens of the soft endoscope for being additionally provided with the gastroscope imaging system of popping one's head in, the soft endoscope and described
Transmission Fibers are in same flexible duct.
2. Raman Gastroscope Diagnosis instrument as claimed in claim 1, it is characterised in that the probe includes projecting light path and collects light
Road；The laser is irradiated on the gastric tissue by the projecting light path, and the light path of collecting collects the drawing for inspiring
Graceful signal transmission gives the spectroanalysis instrument.
3. Raman Gastroscope Diagnosis instrument as claimed in claim 2, it is characterised in that the projecting light path includes the first lens, the
Two lens and bandpass filter, the laser turn into directional light by first lens, and the directional light is by described second
To on the gastric tissue, the bandpass filter is located between first lens and second lens lens focus.
4. Raman Gastroscope Diagnosis instrument as claimed in claim 2, it is characterised in that the collection light path includes collecting lens and length
Pass filter, the Raman signal for inspiring first passes through the pass filter long, is then collected into institute through the collecting lens
State Transmission Fibers.
5. the Raman Gastroscope Diagnosis instrument as described in any one of Claims 1-4, it is characterised in that the laser is 532nm half
Conductor laser or 785nm semiconductor lasers.
6. Raman Gastroscope Diagnosis instrument as claimed in claim 5, it is characterised in that bandwidth is provided with the laser and suppresses core
Piece so that output bandwidth is less than 0.1nm.
7. Raman Gastroscope Diagnosis instrument as claimed in claim 1, it is characterised in that also including display, the soft endoscope
The image in stomach is gathered by the probe, and is shown on the display.
8. Raman detection system as claimed in claim 7, it is characterised in that the spectrum analysis of the Raman Imaging System
After software analysis, display is on the display for the Raman spectrum of instrument output.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107941782A (en) * | 2017-12-11 | 2018-04-20 | 南京航空航天大学 | Can endoscopic fiber Raman microprobe and detection device |
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| CN106404741A (en) * | 2016-10-11 | 2017-02-15 | 北京信息科技大学 | Enhanced Raman spectrum liquid detection method based on double hollow-core fibers |
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| CN107941782A (en) * | 2017-12-11 | 2018-04-20 | 南京航空航天大学 | Can endoscopic fiber Raman microprobe and detection device |
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