WO2017212307A1 - Diagnostic medical device - Google Patents

Diagnostic medical device Download PDF

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Publication number
WO2017212307A1
WO2017212307A1 PCT/IB2016/053303 IB2016053303W WO2017212307A1 WO 2017212307 A1 WO2017212307 A1 WO 2017212307A1 IB 2016053303 W IB2016053303 W IB 2016053303W WO 2017212307 A1 WO2017212307 A1 WO 2017212307A1
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WO
WIPO (PCT)
Prior art keywords
light source
unit
light
output unit
processing unit
Prior art date
Application number
PCT/IB2016/053303
Other languages
French (fr)
Inventor
Imre HAJDU
Original Assignee
Hajdu Imre
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hajdu Imre filed Critical Hajdu Imre
Priority to PCT/IB2016/053303 priority Critical patent/WO2017212307A1/en
Publication of WO2017212307A1 publication Critical patent/WO2017212307A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/43—Detecting, measuring or recording for evaluating the reproductive systems
    • A61B5/4306—Detecting, measuring or recording for evaluating the reproductive systems for evaluating the female reproductive systems, e.g. gynaecological evaluations
    • A61B5/4318—Evaluation of the lower reproductive system
    • A61B5/4331—Evaluation of the lower reproductive system of the cervix

Definitions

  • the subject of the invention is a diagnostic medical device advantageously for diagnosing carcinoma, cervix carcinoma, which includes light source control electronics, a light source connected to the light source control electronics, an input unit connected to the light source, an output unit, a processing unit connected to the output unit, and an evaluating unit connected to processing unit.
  • Known methods of examining the entire human body include various imaging techniques (X-ray, magnetic resonance, ultrasound, computer tomography, and heat camera). The mentioned methods are used for visual examinations.
  • the known methods of examining the cervix - cervix examination using devices, colposcopy, and biopsy, i.e. the taking of samples using thin needle - are also capable of diagnosing cervix carcinoma, but only the latter method is absolutely reliable. If the sampling indicates signs of cancerosis, further examinations are carried out to diagnose any possible metastasis.
  • the above-mentioned methods are visual examinations.
  • optical spectroscope is based on the principle of physics, discovered by Newton in 1666, that white light can be broken down into its component colours with a prism.
  • the great physicists of the 19" 1 century proved that such a breakdown may be achieved because light is composed of waves that have different wave lengths.
  • Optical components e.g. breaking parts
  • a spectroscope is a complex optical device that is used for such purposes. Another term in general use is 'spectrograph', which was used originally to describe a spectroscope that takes a photograph of the spectrum.
  • SG179311 Al uses a polarized light source for fluorescence spectroscopy.
  • the purpose of the invention is to eliminate the shortfalls of the known solutions and to create a device, and implement a procedure for its use, that is capable of providing even more information on diagnosing cervix carcinoma.
  • the inventive step is based on the recognition that an invention that is more advantageous than the previous ones may be achieved by implementing the device according to claim 1. This recognition allows us to determine the entire spectrum of the light reflected from the area under examination, so that diagnostic conclusions can be drawn therefrom.
  • the solution is a diagnostic medical device advantageously for diagnosing carcinoma, cervix carcinoma, which includes light source control electronics, a light source connected to the light source control electronics, an input unit connected to the light source, an output unit, a processing unit connected to the output unit, and an evaluating unit connected to processing unit.
  • a distinctive feature of the invention is that a diverging lens is connected to the output unit, and the diverging lens directs the light reflected from the examined area to the output unit, and the spectrum of the light emitted by the light source covers the visible spectrum.
  • the device has a processing unit that is fitted with a built-in spectroscope and an imaging unit, and the evaluating unit may be a computer typically.
  • the computer evaluates the measured data using software and various algorithms, and displays the output in a visual manner.
  • Another implementation form may be when the device is used to examine the surface of the cervix, primarily to diagnose cervix carcinoma.
  • the input unit, the diverging lens, and the output unit is placed into a tunnel, and the diverging lens is also connected to the input unit.
  • Another implementation form may be when the device is used to examine the surface of the entire body. In such a situation, one or more light source may be used, and the one or more input unit does not need to be connected to the diverging lens.
  • the light of the light source connected to the light source control electronics is directed to the examined area through the input unit, and the light reflected from the examined area is directed to the processing unit through the output unit, and the spectrum information is sent from the processing unit to the evaluating unit.
  • a distinctive feature of the application is that the light reflected from the examined area is directed into the output unit through a diverging lens.
  • Figure 1 shows a longitudinal section and structure of the implementation form according to claim 1.
  • Figure 2 shows a longitudinal section and structure of the implementation form according to claim 2.
  • Figure 1 shows a longitudinal section and the structure of the general implementation form according to claim 1.
  • the light from the examined area 10 enters the diverging lens 3.
  • the diverging lens 3 is connected to the processing unit 5 by the input unit 4.
  • the processing unit 5 is in wired or wireless connection with the evaluating unit 6.
  • the light source electronics 8 is connected to the processing unit 5, and the light source 1 is connected to the light source electronics 8.
  • the light source electronics 8 is fitted with an external light source switch 9.
  • the input unit 2 is connected to the light source 1.
  • Figure 2 shows a longitudinal section and the structure of the implementation form with endoscope according to claim 2.
  • the diverging lens 3 is connected to the processing unit 5 through the input unit 4, and it is connected to the light source 1 through the output unit 2.
  • the input unit 4 and the output unit 2 runs in the same tunnel 7.
  • the processing unit 5 is in wired or wireless connection with the evaluating unit 6.
  • the light source electronics 8 is connected to the processing unit 5, and the light source 1 is connected to the light source electronics 8.
  • the diverging lens may be replaced by another equivalent solution that directs the light reflected from the entire examined area into the output unit and directs the light from the input unit onto the entire examined area.
  • the external light sources may also be applied so that the internal own light source of the device is not used at all.
  • the external light sources may be even used independently from the device.
  • the processing unit typically consists of a light refracting unit and a light detecting unit, but it may be implemented with other equivalent structures as well, so that it detects the intensity of each light component with different wave lengths separately.
  • the described device has numerous advantages.
  • An advantage is that it provides spectrum related information regarding the entire examined area, and it also provides information for detecting any deformation.
  • Another advantage is that the light source has a wide spectrum, thereby providing even more information for diagnostic purposes.
  • diseases that are not yet visible and are not yet detectable by another diagnostic procedure may also be detected during the examination of the entire human body.
  • the unique symptoms of diseases e.g. the symptoms of anaemia, usually take a long time to develop and do not cause any serious complaints in the process, but there are certain signs that may give rise to suspicions regarding the disease.
  • the invention is used on the field of medical diagnostics, primarily to diagnose cervix carcinoma.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Veterinary Medicine (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

The invention is a diagnostic medical device advantageously for diagnosing carcinoma, cervix carcinoma, which includes light source electronics (8), a light source (1) connected to the light source electronics (8), an input unit (2) connected to the light source (1) and directing the light of the light source (1) to the examined area (10), an output unit (4) directing the light reflected from the examined area (10) to the processing unit (5), a processing unit connected to the output unit (5), and an evaluating unit connected to processing unit (6). It is characterized in that a diverging lens (3) is connected to the output unit (4) so that it directs the light reflected from the examined area (10) to the output unit (4), and the spectrum of the light of the light source (1) covers the visible spectrum.

Description

Diagnostic medical device
The subject of the invention is a diagnostic medical device advantageously for diagnosing carcinoma, cervix carcinoma, which includes light source control electronics, a light source connected to the light source control electronics, an input unit connected to the light source, an output unit, a processing unit connected to the output unit, and an evaluating unit connected to processing unit.
The state of the art includes the following solutions:
Known methods of examining the entire human body include various imaging techniques (X-ray, magnetic resonance, ultrasound, computer tomography, and heat camera). The mentioned methods are used for visual examinations.
The known methods of examining the cervix - cervix examination using devices, colposcopy, and biopsy, i.e. the taking of samples using thin needle - are also capable of diagnosing cervix carcinoma, but only the latter method is absolutely reliable. If the sampling indicates signs of cancerosis, further examinations are carried out to diagnose any possible metastasis. The above-mentioned methods are visual examinations.
Actually, the operation of all modern optical spectroscopes is based on the principle of physics, discovered by Newton in 1666, that white light can be broken down into its component colours with a prism. The great physicists of the 19"1 century proved that such a breakdown may be achieved because light is composed of waves that have different wave lengths. Optical components (e.g. breaking parts) direct components with different wave lengths into different directions - a phenomenon called dispersion in physics -, meaning that they can be used to produce a spectrum, i.e. an image of the light source sorted by wave length. A spectroscope is a complex optical device that is used for such purposes. Another term in general use is 'spectrograph', which was used originally to describe a spectroscope that takes a photograph of the spectrum.
The solution described in international patent description No. WO2010070133 A2 applies the Raman process to a cytology sample to diagnose malign tumours. The solution described in American patent description No. US20120259229A1 applies the
Raman process to the skin.
The solution described in American publication document No. US6080584A applies fluorescence spectroscopy to tissue samples in order to diagnose cancerosis and praecancerosis. The solution described in Singapore patent description No.
SG179311 Al uses a polarized light source for fluorescence spectroscopy.
The solution described in international patent document No. WO2005069887A2 uses fluorescence spectroscopy on skin surfaces. The solution described in American publication document No. US20130018237A1 uses the Raman process on skin surfaces. The solutions described in American patent descriptions Nos. US20040152992A1 and US20150335248A1 both use in vivo endoscopic Raman process to detect malign tumours.
The solution described in American patent description No. US20120041290A1 is noteworthy, as it uses polarized multispectral light source for endoscopic spectroscopy.
The solutions described in international patent description No. W09748329A1 and American patent description No. US5991653A use endoscopic Raman process to diagnose uterus cancer.
The solutions described in American patent description No. US5699795A and Canadian patent description No. CA2215207A1 use fluorescence spectroscopy to diagnose uterus cancer.
The solutions described in American patent descriptions Nos. US5467767A and US2007083122A1 also use fluorescence spectroscopy to diagnose benign tumours.
The purpose of the invention is to eliminate the shortfalls of the known solutions and to create a device, and implement a procedure for its use, that is capable of providing even more information on diagnosing cervix carcinoma. The inventive step is based on the recognition that an invention that is more advantageous than the previous ones may be achieved by implementing the device according to claim 1. This recognition allows us to determine the entire spectrum of the light reflected from the area under examination, so that diagnostic conclusions can be drawn therefrom.
In line with the set purpose, the most general implementation form of the solution according to the invention may be implemented according to claim 1. The various implementation forms are described in the sub-claims. In general, the solution is a diagnostic medical device advantageously for diagnosing carcinoma, cervix carcinoma, which includes light source control electronics, a light source connected to the light source control electronics, an input unit connected to the light source, an output unit, a processing unit connected to the output unit, and an evaluating unit connected to processing unit. A distinctive feature of the invention is that a diverging lens is connected to the output unit, and the diverging lens directs the light reflected from the examined area to the output unit, and the spectrum of the light emitted by the light source covers the visible spectrum.
The device has a processing unit that is fitted with a built-in spectroscope and an imaging unit, and the evaluating unit may be a computer typically. The computer evaluates the measured data using software and various algorithms, and displays the output in a visual manner.
Another implementation form may be when the device is used to examine the surface of the cervix, primarily to diagnose cervix carcinoma. In such a situation, the input unit, the diverging lens, and the output unit is placed into a tunnel, and the diverging lens is also connected to the input unit.
Another implementation form may be when the device is used to examine the surface of the entire body. In such a situation, one or more light source may be used, and the one or more input unit does not need to be connected to the diverging lens.
During general use of the invention, the light of the light source connected to the light source control electronics is directed to the examined area through the input unit, and the light reflected from the examined area is directed to the processing unit through the output unit, and the spectrum information is sent from the processing unit to the evaluating unit. A distinctive feature of the application is that the light reflected from the examined area is directed into the output unit through a diverging lens. The invention is presented below in more detail through implementation forms and with drawings.
Figure 1 shows a longitudinal section and structure of the implementation form according to claim 1.
Figure 2 shows a longitudinal section and structure of the implementation form according to claim 2.
Figure 1 shows a longitudinal section and the structure of the general implementation form according to claim 1. The light from the examined area 10 enters the diverging lens 3. The diverging lens 3 is connected to the processing unit 5 by the input unit 4. The processing unit 5 is in wired or wireless connection with the evaluating unit 6. The light source electronics 8 is connected to the processing unit 5, and the light source 1 is connected to the light source electronics 8. The light source electronics 8 is fitted with an external light source switch 9. The input unit 2 is connected to the light source 1.
Figure 2 shows a longitudinal section and the structure of the implementation form with endoscope according to claim 2. The diverging lens 3 is connected to the processing unit 5 through the input unit 4, and it is connected to the light source 1 through the output unit 2. The input unit 4 and the output unit 2 runs in the same tunnel 7. The processing unit 5 is in wired or wireless connection with the evaluating unit 6. The light source electronics 8 is connected to the processing unit 5, and the light source 1 is connected to the light source electronics 8.
The diverging lens may be replaced by another equivalent solution that directs the light reflected from the entire examined area into the output unit and directs the light from the input unit onto the entire examined area.
The external light sources may also be applied so that the internal own light source of the device is not used at all. The external light sources may be even used independently from the device.
The processing unit typically consists of a light refracting unit and a light detecting unit, but it may be implemented with other equivalent structures as well, so that it detects the intensity of each light component with different wave lengths separately.
The described device has numerous advantages. An advantage is that it provides spectrum related information regarding the entire examined area, and it also provides information for detecting any deformation. Another advantage is that the light source has a wide spectrum, thereby providing even more information for diagnostic purposes.
These advantages make it possible to diagnose cervix carcinoma by examining the cervix even before it becomes visible visually. (Visually visible methods include, for example, the use of a microscope or colposcope.) The detection and treatment of a tumour or deformation at an early stage is less burdensome for the patient. The device supports the doctor carrying out the examination to produce a quick and accurate diagnosis. It also makes the examination more comfortable for the patient.
Similarly, diseases that are not yet visible and are not yet detectable by another diagnostic procedure may also be detected during the examination of the entire human body. The unique symptoms of diseases, e.g. the symptoms of anaemia, usually take a long time to develop and do not cause any serious complaints in the process, but there are certain signs that may give rise to suspicions regarding the disease.
The invention is used on the field of medical diagnostics, primarily to diagnose cervix carcinoma.
In addition to the above examples, the invention may be implemented in other forms and with other production processes within the scope of protection.

Claims

1. Diagnostic medical device advantageously for diagnosing carcinoma, cervix carcinoma, which includes light source electronics (8), a light source (1) connected to the light source electronics (8), an input unit (2) connected to the light source (1) and directing the light of the light source (1) to the examined area (10), an output unit (4) directing the light reflected from the examined area (10) to the processing unit (5), a processing unit connected to the output unit (5), and an evaluating unit connected to processing unit (6), characterized in that a diverging lens (3) is connected to the output unit (4) so that it directs the light reflected from the examined area (10) to the output unit (4), and the spectrum of the light of the light source (1) covers the visible spectrum.
2. The device according to claim 1, characterized in that it is fitted with a tunnel (7) that includes the input unit (2) and the output unit (4), and the diverging lens (3) is connected to the input unit (2) as well.
3. The device according to claim 1, characterized in that it is fitted with an external light source switch (9).
PCT/IB2016/053303 2016-06-06 2016-06-06 Diagnostic medical device WO2017212307A1 (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019220438A1 (en) * 2018-05-14 2019-11-21 Mobileodt, Ltd. Method and system for purple light imaging

Citations (17)

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Publication number Priority date Publication date Assignee Title
US5467767A (en) 1991-11-25 1995-11-21 Alfano; Robert R. Method for determining if tissue is malignant as opposed to non-malignant using time-resolved fluorescence spectroscopy
CA2215207A1 (en) 1995-03-31 1996-10-03 Board Of Regents, The University Of Texas System Probe for the detection of cervical neoplasias using fluorescence spectroscopy
US5699795A (en) 1995-03-31 1997-12-23 Board Of Regents, The University Of Texas System Optical probe for the detection of cervical neoplasia using fluorescence spectroscopy and apparatus incorporating same
WO1997048329A1 (en) 1996-06-19 1997-12-24 Board Of Regents, The University Of Texas System Near-infrared raman spectroscopy for in vitro and in vivo detection of cervical precancers
US6080584A (en) 1996-12-02 2000-06-27 The Research Foundation Of City College Of New York Method and apparatus for detecting the presence of cancerous and precancerous cells in a smear using native fluorescence spectroscopy
US20040152992A1 (en) 2003-01-21 2004-08-05 Haishan Zeng In vivo raman endoscopic probe and methods of use
WO2005069887A2 (en) 2004-01-16 2005-08-04 The City College Of The University Of New York Micro-scale compact device for in vivo medical diagnosis combining optical imaging and point fluorescence spectroscopy
US20070083122A1 (en) 2005-09-29 2007-04-12 Research Foundation Of The City University Of New York Phosphorescence and fluorescence spectroscopy for detection of cancer and pre-cancer from normal/benign regions
US20070161876A1 (en) * 2005-11-18 2007-07-12 Spectrx, Inc. Method and apparatus for rapid detection and diagnosis of tissue abnormalities
WO2010070133A2 (en) 2008-12-18 2010-06-24 Dublin Institute Of Technology A diagnostic instrument for cervical cancer screening
US20120041290A1 (en) 2009-01-23 2012-02-16 Beth Israel Deaconess Medical Center, Inc Endoscopic polarized multispectral light scattering scanning method
SG179311A1 (en) 2010-09-22 2012-04-27 Univ Singapore Methods and apparatus relating to integrated nir fluorescence and reflectance imaging and spectroscopy with polarization for improving tissue diagnosis and characterization
US20120259229A1 (en) 2009-12-17 2012-10-11 British Columbia Cancer Agency Branch Apparatus and methods for in vivo tissue characterization by raman spectroscopy
US20130018237A1 (en) 2010-01-07 2013-01-17 Rsp Systems A/S Apparatus for non-invasive in vivo measurement by raman spectroscopy
WO2013132400A1 (en) * 2012-03-08 2013-09-12 Koninklijke Philips N.V. Apparatus for determining a property of a tissue
US20130253335A1 (en) * 2012-03-08 2013-09-26 Dermasensor, Inc. Optical process and apparatus for non-invasive detection of melanoma
US20150335248A1 (en) 2012-07-02 2015-11-26 National University Of Singapore Methods related to real-time cancer diagnostics at endoscopy utilizing fiber-optic raman spectroscopy

Patent Citations (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5467767A (en) 1991-11-25 1995-11-21 Alfano; Robert R. Method for determining if tissue is malignant as opposed to non-malignant using time-resolved fluorescence spectroscopy
US5991653A (en) 1995-03-14 1999-11-23 Board Of Regents, The University Of Texas System Near-infrared raman spectroscopy for in vitro and in vivo detection of cervical precancers
CA2215207A1 (en) 1995-03-31 1996-10-03 Board Of Regents, The University Of Texas System Probe for the detection of cervical neoplasias using fluorescence spectroscopy
US5699795A (en) 1995-03-31 1997-12-23 Board Of Regents, The University Of Texas System Optical probe for the detection of cervical neoplasia using fluorescence spectroscopy and apparatus incorporating same
WO1997048329A1 (en) 1996-06-19 1997-12-24 Board Of Regents, The University Of Texas System Near-infrared raman spectroscopy for in vitro and in vivo detection of cervical precancers
US6080584A (en) 1996-12-02 2000-06-27 The Research Foundation Of City College Of New York Method and apparatus for detecting the presence of cancerous and precancerous cells in a smear using native fluorescence spectroscopy
US20040152992A1 (en) 2003-01-21 2004-08-05 Haishan Zeng In vivo raman endoscopic probe and methods of use
WO2005069887A2 (en) 2004-01-16 2005-08-04 The City College Of The University Of New York Micro-scale compact device for in vivo medical diagnosis combining optical imaging and point fluorescence spectroscopy
US20070083122A1 (en) 2005-09-29 2007-04-12 Research Foundation Of The City University Of New York Phosphorescence and fluorescence spectroscopy for detection of cancer and pre-cancer from normal/benign regions
US20070161876A1 (en) * 2005-11-18 2007-07-12 Spectrx, Inc. Method and apparatus for rapid detection and diagnosis of tissue abnormalities
WO2010070133A2 (en) 2008-12-18 2010-06-24 Dublin Institute Of Technology A diagnostic instrument for cervical cancer screening
US20120041290A1 (en) 2009-01-23 2012-02-16 Beth Israel Deaconess Medical Center, Inc Endoscopic polarized multispectral light scattering scanning method
US20120259229A1 (en) 2009-12-17 2012-10-11 British Columbia Cancer Agency Branch Apparatus and methods for in vivo tissue characterization by raman spectroscopy
US20130018237A1 (en) 2010-01-07 2013-01-17 Rsp Systems A/S Apparatus for non-invasive in vivo measurement by raman spectroscopy
SG179311A1 (en) 2010-09-22 2012-04-27 Univ Singapore Methods and apparatus relating to integrated nir fluorescence and reflectance imaging and spectroscopy with polarization for improving tissue diagnosis and characterization
WO2013132400A1 (en) * 2012-03-08 2013-09-12 Koninklijke Philips N.V. Apparatus for determining a property of a tissue
US20130253335A1 (en) * 2012-03-08 2013-09-26 Dermasensor, Inc. Optical process and apparatus for non-invasive detection of melanoma
US20150335248A1 (en) 2012-07-02 2015-11-26 National University Of Singapore Methods related to real-time cancer diagnostics at endoscopy utilizing fiber-optic raman spectroscopy

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019220438A1 (en) * 2018-05-14 2019-11-21 Mobileodt, Ltd. Method and system for purple light imaging

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