CN211749542U - Endoscopic Raman spectrum detection device for intracavity tissue - Google Patents
Endoscopic Raman spectrum detection device for intracavity tissue Download PDFInfo
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- CN211749542U CN211749542U CN201921866518.8U CN201921866518U CN211749542U CN 211749542 U CN211749542 U CN 211749542U CN 201921866518 U CN201921866518 U CN 201921866518U CN 211749542 U CN211749542 U CN 211749542U
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Abstract
The utility model provides an endoscopic Raman spectrum detection device for intracavity tissues, which comprises a handheld probe, wherein the handheld probe is provided with a probe bracket and an optical fiber probe; the probe bracket comprises a handheld part and a hollow probe guide pipe, and the handheld part is connected to one end of the probe guide pipe; the head end and the tail end of the probe guide pipe are both of an open structure, one end of the probe guide pipe corresponding to the handheld part is an inlet end, and the other end of the probe guide pipe is a detection end; the optical fiber probe penetrates through the inlet end and is fixed in the probe guide tube. The utility model is suitable for a nasopharynx endoscope does not occupy nasopharynx endoscope's biopsy channel, reserves the passageway of biopsy channel and extraction intracavity mucus for the doctor, and handheld probe can not only use with the empty endoscope cooperation that has the biopsy hole, but also can detect nasopharyngeal tissue together with endoscope or the hard nasopharynx mirror that does not have the biopsy hole. The utility model can also be applied to stomatoscope, hysteroscope, etc., thereby satisfying the observation requirements of different parts in the human body cavity.
Description
[ technical field ] A method for producing a semiconductor device
The utility model particularly relates to an endoscopic Raman spectrum detection device for intracavity tissues.
[ background of the invention ]
Nasopharyngeal carcinoma is one of the malignant tumors that occur in the head and neck, mainly in some countries in fujian province, guangdong province, hong kong, southeast asia, and asia in china. Early nasopharyngeal carcinoma is difficult to be detected because the nasopharyngeal carcinoma has no obvious symptoms at the early stage and is located in the deep part of the head and neck. By the time nasopharyngeal carcinoma is diagnosed, more than 70% of patients with nasopharyngeal carcinoma are in the middle and advanced stage. The survival rate of the patients with early nasopharyngeal carcinoma exceeds 90 percent, and the survival rate of the patients with late nasopharyngeal carcinoma is lower than 30.3 percent. Therefore, early diagnosis of nasopharyngeal carcinoma becomes a key to the treatment of nasopharyngeal carcinoma. Conventional diagnostic methods include: nasopharyngoscope examination, Magnetic Resonance Imaging (MRI), Computed Tomography (CT), tissue biopsy, etc., but these methods have disadvantages of high cost, long time, secondary injury, and the need to rely on the clinical experience of a doctor, and it is difficult to make an early diagnosis of nasopharyngeal carcinoma.
The Raman spectrum technology is a nondestructive optical detection technology, obtains the Raman spectrum of tissues through the interaction between light and the tissues, and has diagnostic significance for diseases of human tissues by providing very important biochemical information through the Raman spectrum. Therefore, the Raman spectrum detection research of human tissues is of great significance for early nondestructive cancer screening.
However, the conventional nasopharyngeal endoscope raman spectrum detection device adopts a fiber endoscope, the biopsy hole of the fiber endoscope is large, an optical probe is relatively easy to install, the raman spectrum can be detected based on the biopsy channel, but the fiber endoscope is easy to damage, and the raman spectrum detection is adopted, the fiber probe must pass through an instrument of the endoscope biopsy channel to enter the human body cavity, and the fiber probe occupies the biopsy channel for clamping and taking a pathological examination sample, and can not extract mucus in the cavity through the biopsy hole, so that abnormal tissues can not be found in a blurred field of view under white light, even if the abnormal tissues are found, the mucus can interfere with the detection of the raman signal, the signal to noise ratio is reduced, in addition, the steering angle of the fiber probe based on the endoscope biopsy channel depends on the endoscope, and because the fiber probe is limited by the bending angle of the endoscope, the fiber endoscope cannot be flexibly operated, blind areas can be caused, the, the measured signal is a blood signal. At present, a nasopharynx fiberscope is replaced by a nasopharynx electronic endoscope with high observed definition, and a biopsy hole of the nasopharynx electronic endoscope is smaller or has no biopsy channel. For nasopharynx electron mirror without biopsy hole, there is no biopsy channel, and the existing raman probe passing through the biopsy hole is unusable, so it is urgently needed to develop a device for performing nasopharynx tissue spectrum detection by closely combining with the electron nasopharynx mirror.
[ Utility model ] content
In order to overcome the defects of the prior equipment, the utility model provides an endoscopic Raman spectrum detection device for intracavity tissues.
The utility model discloses a realize like this: an endoscopic Raman spectrum detection device for intracavity tissues comprises a handheld probe, a probe support and a fiber-optic probe, wherein the handheld probe is provided with the probe support and the fiber-optic probe; the probe bracket comprises a handheld part and a hollow probe guide pipe, and the handheld part is connected to one end of the probe guide pipe; the head end and the tail end of the probe guide pipe are both of an open structure, one end of the probe guide pipe corresponding to the handheld part is an inlet end, and the other end of the probe guide pipe is a detection end; the optical fiber probe penetrates through the inlet end and is fixed in the probe guide tube.
Furthermore, a fastening piece is arranged at the position, corresponding to the inlet end, of the probe guide pipe, the optical fiber probe is connected into the probe guide pipe in a sliding mode, and the optical fiber probe is fixed into the probe guide pipe through the fastening piece.
Furthermore, a quartz glass column is arranged at the detection end of the probe guide pipe, and the optical fiber probe is closely attached to the quartz glass column.
Furthermore, the front end of the quartz glass column is provided with a fillet.
Further, handheld portion includes handle and finger hole, the lower extreme of handle is located in the finger hole.
Further, the optical fiber probe comprises a Raman excitation optical fiber, a plurality of Raman collection optical fibers, a fluorescence/reflection excitation optical fiber and a fluorescence/reflection collection optical fiber; the plurality of Raman collection optical fibers enclose a circle; the Raman excitation optical fiber, the fluorescence/reflection excitation optical fiber and the fluorescence/reflection collection optical fiber are arranged in an equilateral triangle and are all positioned in the circle.
Furthermore, the front end face of the Raman excitation fiber is coated with a low-pass film which allows laser with one wavelength to pass through, and the front end of the Raman collection fiber is provided with a high-pass filter which can cut off the excitation light and allows Raman scattered light with larger wavelength to pass through.
Further, the device also comprises a Raman spectrometer, a Raman excitation light source, a white light source, a fluorescence excitation light source, a reflection/fluorescence spectrometer and a detector; the Raman spectrometer is connected with the output ends of the plurality of Raman collecting optical fibers; the output end of the Raman excitation light source is connected with the Raman excitation optical fiber; the white light source and the fluorescence excitation light source are connected with the input end of the fluorescence/reflection excitation optical fiber through a first filter; the reflection/fluorescence spectrometer is connected with the output end of the fluorescence/reflection collection optical fiber through the filter wheel; the Raman spectrometer and the reflection/fluorescence spectrometer are both connected with the detector.
The utility model has the advantages that: does not depend on an endoscope, does not occupy a biopsy channel, reserves a biopsy channel and a channel for extracting mucus in a cavity for a doctor, and is suitable for being combined with a nasopharynx electronic endoscope without a biopsy hole; the handheld probe can be matched with an empty endoscope with a biopsy hole for use, can also be used for detecting nasopharyngeal tissues together with an endoscope without a biopsy hole or a nasopharynx hard mirror, can also be made into a hard mirror form, and realizes accurate measurement of multiple angles by utilizing a steering lens; the signal to noise ratio is improved, the pollution of the probe is avoided, and the service life of the probe is prolonged; the Raman spectrum detection can be realized, and the sensitivity and specificity of the detection are improved. The utility model can also be applied to endoscopes with different types of functions, such as nasopharyngoscope, stomatoscope, hysteroscope, etc., thereby satisfying the observation requirements of different parts in the human body cavity.
[ description of the drawings ]
The invention will be further described with reference to the following examples with reference to the accompanying drawings.
Fig. 1 is a schematic structural diagram of the endoscopic raman spectroscopy apparatus for intracavity tissue of the present invention.
Fig. 2 is a schematic structural diagram of the middle probe bracket of the present invention.
Fig. 3 is a schematic structural diagram of the middle optical fiber probe of the present invention.
Fig. 4 is a schematic structural diagram of a preferred embodiment of the hand-held probe of the present invention.
Fig. 5 is a usage state diagram of the endoscopic raman spectroscopy apparatus for intraluminal tissue of the present invention.
[ detailed description ] embodiments
Referring to fig. 1 to 5, an endoscopic raman spectroscopy apparatus 100 for detecting an intracavity tissue includes a hand-held probe 1, a raman spectrometer 2, a raman excitation light source 3, a white light source 4, a fluorescence excitation light source 5, a reflection/fluorescence spectrometer 6, a detector (not shown), and an endoscope system 7; the hand-held probe 1 has a probe holder 11 and a fiber-optic probe 12.
Referring to fig. 1 and 2 again, the probe holder 11 includes a hand-held portion 111 and a hollow probe guide tube 112, the hand-held portion 111 is connected to one end of the probe guide tube 112; handheld portion 111 includes handle 111a and finger hole 111b, finger hole 111b locates the lower extreme of handle 111 a. The head and the tail of the probe guide tube 112 are both open structures, one end of the probe guide tube 112 corresponding to the hand-held part 111 is an inlet end 1121, and the other end is a probing end 1122; the fiber optic probe 12 passes through the inlet end 1121 and is secured within a probe conduit 112 and extends to the probing end 1122. A fastening piece 8 is disposed on the probe guide tube 112 corresponding to the inlet end 1121, the fiber optic probe 12 is slidably connected in the probe guide tube 112, and the fiber optic probe 12 is fixed in the probe guide tube 112 through the fastening piece 8. The optical fiber probe 12 can be turned along with the tightening piece 8, and the length of the optical fiber probe 12 entering the channel of the probe bracket 11 can be adjusted, so that when the optical fiber probe 12 enters the human body cavity for detection, the end surface of the detection end 1122 of the optical fiber probe does not contact the mucosal tissue in the human body cavity, and medical risks such as bleeding and infection caused by damage to the mucosal tissue in the cavity are avoided; the fastening piece 8 can be a locking nut, the optical fiber probe 12 and the probe bracket 11 are fixed through the fastening piece 8, deviation of measurement point positions caused by lateral tilting, movement and the like of the optical fiber probe 12 in the measurement process can be prevented, and the positioning precision of the optical fiber probe 12 to the focus is improved.
Referring to fig. 1, 2 and 3, in a preferred embodiment, a quartz glass column 9 is disposed at the probing end 1122 of the probe guide 112, and the optical fiber probe 12 abuts against the quartz glass column 9. The front end of the quartz glass column is provided with a fillet; this prevents the quartz glass column from being inserted into tissue inside the cavity when the probe 1122 is in the cavity. The front end face of the quartz glass column 9 is plated with the reflection increasing film, the quartz glass column 9 not only limits the distance between the optical fiber probe 12 and the tissue to obtain a stable tissue signal in an optical cavity, the probe bracket 11 and the quartz glass column 9 can avoid the direct contact between the optical fiber probe 12 and the tissue, the cleanliness of the front end of the optical fiber probe 12 is protected, the signal collection efficiency is ensured, meanwhile, when the next patient is detected, the probe bracket 11 can be directly replaced, the optical fiber probe 12 does not need to be cleaned again, and therefore the service life of the optical fiber probe 12 is prolonged, and the detection time is shortened. The probe holder 11 is made of stainless steel or other rigid and biocompatible materials, and can directly contact the tissue in the human body cavity.
Referring to fig. 1 and 3 again, the fiber-optic probe 12 includes a raman excitation fiber 121, a plurality of raman collecting fibers 122, a fluorescence/reflectance excitation fiber 123 and a fluorescence/reflectance collecting fiber 124; the plurality of raman collection fibers 122 enclose a circle O; the raman excitation fiber 121, the fluorescence/reflectance excitation fiber 123, and the fluorescence/reflectance collection fiber 124 are arranged in an equilateral triangle and are all located within the circle O. The middle parts of the raman excitation fiber 121, the raman collection fiber 122, the fluorescence/reflectance excitation fiber 123 and the fluorescence/reflectance collection fiber 124 are integrated into a beam combining fiber, and are fixed at the detection end 1122 by a metal sleeve. The three middle optical fibers are in an equilateral triangle structure, so that collected multispectral can be converged on the same detection point. The Raman spectrometer 2 is connected with the output ends of a plurality of Raman collection optical fibers 122; the output end of the Raman excitation light source 3 is connected with a Raman excitation optical fiber 121; the white light source 4 and the fluorescence excitation light source 5 are connected with the input end of the fluorescence/reflection excitation optical fiber 123 through a first filter 101; the reflection/fluorescence spectrometer 6 is connected with the output end of the fluorescence/reflection collection optical fiber 124 through the filter wheel 102; the Raman spectrometer 2 and the reflection/fluorescence spectrometer 6 are both connected with a detector. The detector is connected to a display 103. The fiber-optic probe 12 can acquire the reflection spectrum, fluorescence spectrum and raman spectrum signals of the tissue in the cavity, wherein the raman signal excitation and receiving part is formed by plating a low-pass film which allows the excitation light with one wavelength to pass through on the end surface of the raman excitation fiber 121, and a high-pass filter which can cut off the excitation light and allow the raman scattered light with a larger wavelength to pass through is adopted at the front end of the raman collection fiber 122 and then assembled together. The low wave number (200-2000 cm) of the reflection spectrum, the fluorescence spectrum and the Raman spectrum can be collected-1Finger print) and high wave number (2600-3500 cm)-1High wave number) to achieve the full-range spectrum detection of the tissue in the cavity and improve the detection efficiency. The utility model uses the white light source 4 asThe reflection spectrum detection of the excitation light source and the fluorescence spectrum detection of the blue light source as the excitation light.
Referring to fig. 1 and 5 again, the endoscope system 7 includes an endoscope 71, a second filter 72, a xenon lamp light source 73 and a data processor 74, wherein the endoscope 71, the second filter 72 and the xenon lamp light source 73 are connected in sequence; the endoscope 71, the data processor 74 and the display 103 are connected in sequence. The xenon lamp light source 73 outputs white light as illumination light of the endoscope 71 to illuminate the tissue in the cavity, the data processor 74 can record the white light optical image observed under the endoscope 71 in real time, and the optical fiber probe 12 simultaneously enters the cavity to collect the spectrum signal to be processed in real time and displayed through the display device. The optical fiber probe 12 and the endoscope 71 can enter the human body cavity to reach the tissue to be detected at the same time to obtain the white light image of the tissue in the cavity and the spectrum signals such as the reflection spectrum, the fluorescence spectrum, the Raman spectrum and the like, thereby realizing the simultaneous detection of various optical signals. When the endoscope 71 is a nasopharyngoscope, the nasopharyngoscope is slowly inserted along one nasal cavity of a human body after disinfection treatment, the probe support 11 is inserted from the other nasal cavity of the human body, the nasopharyngoscope is guided to reach the vicinity of a nasopharyngoscope tissue under the guidance of a white light image displayed on the display 103, observation and spectrum collection of an optical image are carried out, then a white light excitation light source is started, fluorescence imaging is collected, so that a doctor can respectively observe the white light image of the nasopharyngoscope tissue under white light illumination, and when the doctor finds suspicious lesion tissues in the image observation process, a reflection spectrum under the white light illumination and a fluorescence spectrum under the blue light illumination are collected and observed on the display 103; meanwhile, the handheld probe support 11 can be in contact with a tissue, the 785nm Raman excitation light source 3 is started to emit laser, the suspicious tissue is excited through the excitation optical fiber, Raman spectrum signals of the tissue are collected through the collection optical fiber and transmitted to the Raman spectrometer 2 for detection, the nasopharyngeal Raman detection is realized, and optical images and spectrum signals can be processed through the detector and stored in real time.
Referring to fig. 4, the present invention can enter the body cavity separately from the electronic endoscope 71 to perform multispectral measurement of the tissue in the body cavity, and can be used in conjunction with the current clinical endoscope 71 and pharyngoscope examination to quickly obtain high-quality multispectral signals of the nasopharyngeal tissue, and to effectively detect the nasopharyngeal cancerous tissue at the molecular level. When the method is applied to the detection of nostrils at two sides, one side is used for observing images, and the other side is used for collecting Raman signals, so that the collection efficiency of Raman light can be improved. The utility model discloses a handheld probe 1 can not only use with the empty endoscope cooperation that has the biopsy hole, but also can detect nasopharyngeal tissue with the endoscope or the nasopharynx hard mirror that do not have the biopsy hole together, also can make the hard mirror form. The utility model discloses a handheld probe 1 and nasopharynx scope ally oneself with and use, do not occupy the biopsy passageway, can combine with the nasopharynx electron mirror that does not have the biopsy at present, realized the high combination with clinical nasopharynx mirror inspection, have very high clinical application and worth. The utility model can also be applied to endoscopes 71 with different types of functions, such as nasopharyngoscope, stomatoscope, hysteroscope, etc., thereby satisfying the observation requirements of different parts in the human body cavity; the hand-held probe can also be suitable for multispectral detection of skin, biopsy tissues and the like in the human body, the coverage range of the Raman spectrum detection system is wide, and the Raman spectrum of a fingerprint area and a high-wavenumber area can be detected simultaneously; provides an effective clinical detection tool for nondestructive and rapid diagnosis of living tissues.
Claims (9)
1. An endoscopic Raman spectrum detection device for intracavity tissues is characterized in that: the device comprises a handheld probe, a probe support and a fiber-optic probe, wherein the handheld probe is provided with the probe support and the fiber-optic probe; the probe bracket comprises a handheld part and a hollow probe guide pipe, and the handheld part is connected to one end of the probe guide pipe; the head end and the tail end of the probe guide pipe are both of an open structure, one end of the probe guide pipe corresponding to the handheld part is an inlet end, and the other end of the probe guide pipe is a detection end; the optical fiber probe penetrates through the inlet end and is fixed in the probe guide tube.
2. The endoscopic raman spectroscopy apparatus for intraluminal tissue according to claim 1, wherein: the probe guide pipe is provided with a fastening piece corresponding to the inlet end, the optical fiber probe is connected in the probe guide pipe in a sliding mode, and the optical fiber probe is fixed in the probe guide pipe through the fastening piece.
3. The endoscopic raman spectroscopy apparatus for intraluminal tissue according to claim 1, wherein: the probe end of the probe guide pipe is provided with a quartz glass column, and the optical fiber probe is closely connected to the quartz glass column.
4. The endoscopic raman spectroscopy apparatus for intraluminal tissue according to claim 3, wherein: and the front end of the quartz glass column is provided with a fillet.
5. The endoscopic raman spectroscopy apparatus for intraluminal tissue according to claim 1, wherein: the probe holder is made of stainless steel or a rigid, biocompatible material.
6. The endoscopic raman spectroscopy apparatus for intraluminal tissue according to claim 1, wherein: the handheld portion comprises a handle and finger holes, and the finger holes are formed in the lower end of the handle.
7. The endoscopic raman spectroscopy apparatus for intraluminal tissue according to claim 1, wherein: the optical fiber probe comprises a Raman excitation optical fiber, a plurality of Raman collection optical fibers, a fluorescence/reflection excitation optical fiber and a fluorescence/reflection collection optical fiber; the plurality of Raman collection optical fibers enclose a circle; the Raman excitation optical fiber, the fluorescence/reflection excitation optical fiber and the fluorescence/reflection collection optical fiber are arranged in an equilateral triangle and are all positioned in the circle.
8. The endoscopic raman spectroscopy apparatus for intraluminal tissue according to claim 7, wherein: the front end face of the Raman excitation optical fiber is plated with a low-pass film which allows laser with one wavelength to pass through, and the front end of the Raman collection optical fiber is provided with a high-pass filter which can cut off the excitation light and allows Raman scattered light with longer wavelength to pass through.
9. The endoscopic raman spectroscopy apparatus for intraluminal tissue according to claim 7, wherein: the device also comprises a Raman spectrometer, a Raman excitation light source, a white light source, a fluorescence excitation light source, a reflection/fluorescence spectrometer and a detector; the Raman spectrometer is connected with the output ends of the plurality of Raman collecting optical fibers; the output end of the Raman excitation light source is connected with the Raman excitation optical fiber; the white light source and the fluorescence excitation light source are connected with the input end of the fluorescence/reflection excitation optical fiber through a first filter; the reflection/fluorescence spectrometer is connected with the output end of the fluorescence/reflection collection optical fiber through the filter wheel; the Raman spectrometer and the reflection/fluorescence spectrometer are both connected with the detector.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921866518.8U CN211749542U (en) | 2019-11-01 | 2019-11-01 | Endoscopic Raman spectrum detection device for intracavity tissue |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921866518.8U CN211749542U (en) | 2019-11-01 | 2019-11-01 | Endoscopic Raman spectrum detection device for intracavity tissue |
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| CN211749542U true CN211749542U (en) | 2020-10-27 |
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| CN201921866518.8U Expired - Fee Related CN211749542U (en) | 2019-11-01 | 2019-11-01 | Endoscopic Raman spectrum detection device for intracavity tissue |
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