CN104524448B - A kind of Chinese medicine preparation preparation method for treating fatty liver and hyperlipidemia - Google Patents

A kind of Chinese medicine preparation preparation method for treating fatty liver and hyperlipidemia Download PDF

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Publication number
CN104524448B
CN104524448B CN201410794632.XA CN201410794632A CN104524448B CN 104524448 B CN104524448 B CN 104524448B CN 201410794632 A CN201410794632 A CN 201410794632A CN 104524448 B CN104524448 B CN 104524448B
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China
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parts
preparation
ethyl alcohol
hyperlipidemia
fatty liver
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CN201410794632.XA
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CN104524448A (en
Inventor
耿秀丽
马俊杰
王华民
吕宏迪
王希东
郝少君
孙建华
李献玉
李文俊
张正臣
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No371 Hospital Of Pla
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No371 Hospital Of Pla
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Abstract

The present invention provides a kind of Chinese medicine preparation preparation method for treating fatty liver and hyperlipidemia, including:(1) curcuma zedoary of certain mass, radix paeoniae rubra, hawthorn, gynostemma pentaphylla, Cassia occidentalis, giant knotweed, turmeric, Radix Astragali, matrimony vine are weighed;(2) water of 68 times of weight of the total weight of the nine traditional Chinese medicines of the above selection is taken to be decocted, it decocts three times, it boils 40 50 minutes every time, it filters and merges decoction liquor, it is concentrated into the inspissated juice of relative density 1.15 1.30 at a temperature of 80 DEG C, then the ethyl alcohol that mass percent concentration is 95% is added at ambient temperature, it is stirring while adding, then place 24 hours or more, extract supernatant;(3), the ethyl alcohol in supernatant is recycled, then gives back in the supernatant for harvest ethyl alcohol and sweetener is added, the pH value for adjusting solution is 5.0 7.0, finally adds suitable quantity of water;Filtering, sterilizing and filling.Chinese medicine preparation prepared by preparation method of the present invention can effectively treat fatty liver and hyperlipidemia, and cheap.

Description

A kind of Chinese medicine preparation preparation method for treating fatty liver and hyperlipidemia
Technical field
The present invention relates to technical field of traditional Chinese medicines more particularly to a kind of Chinese medicine preparations for treating fatty liver and hyperlipidemia Preparation method.
Background technology
Fatty liver is a kind of disease relatively conventional in modern diseases.The disease incidence up to 50% or so, and focus mostly in 30~60 years old males.Mild fatty liver is mostly without clinical symptoms.In, severe fatty liver have the performance of similar chronic hepatitis, can have Loss of appetite, lassitude and weak, Nausea and vomiting, hepatic region or upper right abdomen secret anguish, if cannot effectively treat, to eventually result in liver hard Change etc..Hyperlipidemia is a kind of rich people's disease for perplexing modern, it can increase the viscosity of blood, endangers blood circulation system and forms blood Pipe hardens.Hyperlipidemia can lead to coronary heart disease, hypertension.Eventually lead to diabetes, sudden death of heart disease, apoplexy etc..To being at present Only, Western medicine there is no prevention fatty liver and hyperlipidemia active drug, though and have some treat patients in terms of Chinese medicine composition, Using the Chinese medicine composition of current preparation method preparation, its curative effect is not good enough, therefore, needs the existing side for preparing Chinese medicine composition Method is improved, to improve curative effect.
Invention content
It is an object of the invention to solve the problems of the above-mentioned prior art, provide a kind of for treating fatty liver and height The Chinese medicine preparation preparation method of pionemia, the Chinese medicine preparation treatment patient outcome prepared using the preparation method are apparent.
A kind of Chinese medicine preparation preparation method for treating fatty liver and hyperlipidemia includes the following steps:
(1) curcuma zedoary of certain mass, radix paeoniae rubra, hawthorn, gynostemma pentaphylla, Cassia occidentalis, giant knotweed, turmeric, Radix Astragali, matrimony vine are weighed;
(2) it takes the water of 6-8 times of weight of the total weight of the nine traditional Chinese medicines of the above selection to be decocted, decocts three times, every time It boils 40-50 minutes, filters and merge decoction liquor, the inspissated juice of relative density 1.15-1.30 is concentrated at a temperature of 80 DEG C, The ethyl alcohol that mass percent concentration is 95% is added at ambient temperature again, it is stirring while adding, then place 24 hours or more, it carries Take supernatant;
(3), the ethyl alcohol in supernatant is recycled, then gives back in the supernatant for harvest ethyl alcohol and sweetener is added, adjusted molten The pH value of liquid is 5.0-7.0, finally adds suitable quantity of water;
(4), preparation can be completed in filtering, sterilizing and filling.
Further, the Chinese medicine preparation preparation method as described above for treating fatty liver and hyperlipidemia, the matter The addition for the ethyl alcohol that amount percent concentration is 95% is 1.2-2 times of the gross mass of inspissated juice.
Further, the Chinese medicine preparation preparation method for treating fatty liver and hyperlipidemia as described above, in step 1 The mass parts of each traditional Chinese medicinal components are:15 parts -75 parts of curcuma zedoary, 12 parts -60 parts of radix paeoniae rubra, 12 parts -60 parts of hawthorn, gynostemma pentaphylla 12 - 60 parts of part, 12 parts -60 parts of Cassia occidentalis, 15 parts -75 parts of giant knotweed, 12 parts -60 parts of turmeric, 15 parts -75 parts of Radix Astragali, matrimony vine 15 - 75 parts of part.
Provided by the present invention for treating the Chinese medicine preparation preparation method of fatty liver and hyperlipidemia, fat can be effectively treated Fat liver and hyperlipidemia, and it is cheap.
Specific implementation mode
To make the object, technical solutions and advantages of the present invention clearer, the technical solution below in the present invention carries out clear Chu is fully described by, it is clear that described embodiments are some of the embodiments of the present invention, instead of all the embodiments.It is based on Embodiment in the present invention, those of ordinary skill in the art are obtained every other without creative efforts Embodiment shall fall within the protection scope of the present invention.
The treatment fatty liver of the present invention and the Chinese medicine preparation preparation method of hyperlipidemia are as follows:
(1) 15 parts -75 parts of curcuma zedoary of selection, 12 parts -60 parts of radix paeoniae rubra, 12 parts -60 parts of hawthorn, 12 parts -60 parts of gynostemma pentaphylla, 12 parts -60 parts of Cassia occidentalis, 15 parts -75 parts of giant knotweed, 12 parts -60 parts of turmeric, 15 parts -75 parts of Radix Astragali, 15 parts -75 parts of matrimony vine;
(2) it takes the water of 6-8 times of weight of the total weight of the nine traditional Chinese medicines of the above selection to be decocted, decocts three times, every time It boils 40-50 minutes, filters and merge decoction liquor, be concentrated into the inspissated juice of relative density 1.15-1.30 (80 DEG C), then in room temperature Under the conditions of the ethyl alcohol that mass percent concentration is 95% is added, the addition of the ethyl alcohol is the 1.2-2 of the total weight of inspissated juice Times, it is stirring while adding, after addition, place 24 hours or more, extract supernatant;
(3), remaining ethyl alcohol in supernatant is recycled, gives back to and sweetener is added in the supernatant for harvest ethyl alcohol, adjusted molten The pH value of liquid is 5.0-7.0, and finally plus water stirs evenly standing;
(4), preparation can be completed in filtering, sterilizing and filling.
It is by using Chinese medicine preparation treatment curative effect prepared by preparation method of the present invention below:
Example 1:
Name:So-and-so tall gender:Female's age:61 years old addresses:Xinxiang Ma little Ying
There is aphasia in patient, upper left myasthenia of limbs is admitted to hospital, with dizziness, palpitaition, difference of receiving.Human health screening, blood pressure 170/ 100mmhg, sanity, aphasia, left center face tongue paralysis, white and greasy fur, Cervical Vessels are not heard and exception.Under upper left 4 grades of muscular strength, hypomyotonia, left side pathology sign are positive.Head CT shows that multiple cerebral, blood fat show total cholesterol 7.28mol/ L, triglyceride 2.19mol/L, high density cholesterol 1.22mol/L, low density cholesterol 4.70mol/L.Enter section's diagnosis:It is multiple Property cerebral infarction, hyperlipidemia.It is routinely given to symptomatic treatments such as anti-bolt, improvement brain blood circulations after entering section, while adding and using mouth of the present invention It takes liquid 20ml/ times, takes orally 3 times a day, blood fat is checked after 20 days and shows that 3.87mol/L, triglyceride 1.5mol/L, high density courage consolidate Alcohol 1.92mol/L, low density cholesterol 2.28mol/L, is obviously improved when being relatively admitted to hospital, significant in efficacy, advises usually low fat diet, after Continuous oral maintaining treatment.
Example 2:
Name:Yang's gender:The male age:58 years old addresses:Newly there is burst dizziness in electric cell patient in Xinxiang, left Side myasthenia of limbs is admitted to hospital, with dizziness, palpitaition, difference of receiving, existing coronary heart disease, atrial fibrillation disease official.Human health screening, blood pressure 150/90mmhg, Sanity, spirit is poor, and speech is fluent, and tongue nature is slightly dark, white and greasy fur, and Cervical Vessels are not heard and exception.5 grades of muscular strength under upper left, Hypomyotonia, left side pathology sign are positive.Head MRL shows that multiple cerebral, blood fat show total cholesterol 6.15mol/L, glycerine Three fat 2.95mol/L, high density cholesterol 0.75mol/L, low density cholesterol 4.36mol/L.Enter section's diagnosis:Cerebral infarction is high Pionemia.It is routinely given to symptomatic treatments such as anti-bolt, improvement brain blood circulations after entering section, while adding use oral solution of the present invention 20ml/ times, It takes orally 3 times a day, blood fat is checked after 20 days and shows 3.51mol/L, triglyceride 0.58mol/L, high density cholesterol 2.12mol/ L, low density cholesterol 1.78mol/L, is obviously improved when being relatively admitted to hospital, significant in efficacy, advises usually low fat diet, continues oral maintenance Treatment.
Example 3:
Name:So-and-so gender of Meng:Female's age:60 years old addresses:Xinxiang West Platform head
There is left limb hemiplegia 2 weeks in patient, and abdominal distension is received poor 10 days and is admitted to hospital, the past body obesity, 10 years high blood pressures Official, human health screening, weight 80KG, blood pressure 164/102mmhg, sanity, spirit is poor, and aphasia, abdominal distension, appetite is fine, No nausea is intended to spit, when feel nose heave, tongue nature is slightly dark, and tongue is greasy in vain, and stringy and hesitant pulse, neck is soft, 3 grades of muscular strength under upper right, and pathology sign in right side is negative. Head MRL shows that multiple cerebral, encephalatrophy, blood fat show total cholesterol 8.12mol/L, triglyceride 5.26mol/L, high density Cholesterol 0.79mol/L, low density cholesterol 5.53mol/L.Enter section's diagnosis:Cerebral infarction, hyperlipidemia.It is routinely given after entering section Anti- bolt improves the symptomatic treatments such as brain blood circulation, while adding use oral solution of the present invention 20ml/ times, takes orally 3 times a day, multiple after 20 days Fat of having a blood test shows 5.03mol/L, triglyceride 2.58mol/L, high density cholesterol 1.52mol/L, low density cholesterol 2.38mol/L is obviously improved when being relatively admitted to hospital, significant in efficacy, advises usually low fat diet, continues oral maintaining treatment.
Example 4:
Name:Slowly so-and-so gender:The male age:55 years old
There is dizzy, weak, right hypochondriac region discomfort in patient before last week, secret anguish gradually aggravates to be admitted to hospital, with loss of appetite, abdomen It is swollen, belch, hepatic region turgor;Previously there is high blood pressure medical history 10 years;History of coronary heart disease 5 years.Physical examination, 160/95mmhg, mind is clear, Spiritual poor, chronic face, auscultation of lung no abnormality seen, heart circle expand to left down, 70 beats/min of heart rate.A2>P2, abdominal distention, liver Palpation of spleen owes satisfaction, and Murphy signs are negative, have no liver distension of jugular vein.Other are checked:Electrocardio illustrates:Deficiency myocardial blood supply surpasses Sound prompts:Severe fatty liver;Chemically examine blood fat, total cholesterol 7.2mmol/L, triglyceride 4.8mmol/L, low-density lipoprotein 0.86mmol/L.Liver function:Glutamic-oxalacetic transaminease 51mmol/L, glutamic-pyruvic transaminase 78mmol/L, hepatitis B surface antigen (-) property surpass Sound prompts:Severe fatty liver;Clinical diagnosis:1 fatty liver (severe) 2, hyperlipidemia 3,2 grade 4 of hypertension, coronary heart disease;Main application Following therapy, reducing blood lipid, decompression, expansion of coronary artery wait symptomatic treatments, while adding and using oral solution of the present invention 20ml/ times, 3 times a day;Symptom is substantially reduced, and blood pressure stabilization is normal, and the aobvious amount of electrocardiogram degree of ischemia mitigates, under the aobvious amount of blood fat Drop, significantly effectively reach clinical cure standard, the 23rd day check blood fat, total cholesterol 4.8mmol/L, triglyceride 1.5mmol/L, Low-density albumen 3.21mmol/L, high-density protein 1.98mmol/L.It advises patient's low fat diet, moderate exercise to adhere to taking medicine, consolidates Gu curative effect.
Finally it should be noted that:The above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations;Although Present invention has been described in detail with reference to the aforementioned embodiments, it will be understood by those of ordinary skill in the art that:It still may be used With technical scheme described in the above embodiments is modified or equivalent replacement of some of the technical features; And these modifications or replacements, various embodiments of the present invention technical solution that it does not separate the essence of the corresponding technical solution spirit and Range.

Claims (2)

1. a kind of Chinese medicine preparation preparation method for treating fatty liver and hyperlipidemia, which is characterized in that include the following steps:
(1) curcuma zedoary of certain mass, radix paeoniae rubra, hawthorn, gynostemma pentaphylla, Cassia occidentalis, giant knotweed, turmeric, Radix Astragali, matrimony vine are weighed;
(2) it takes the water of 6-8 times of weight of the total weight of the nine traditional Chinese medicines of the above selection to be decocted, decocts three times, boil every time 40-50 minutes, decoction liquor is filtered and merged, is concentrated into the inspissated juice of relative density 1.15-1.30 at a temperature of 80 DEG C, then The ethyl alcohol that mass percent concentration is 95% is added under room temperature, it is stirring while adding, then place 24 hours or more, in extraction Clear liquid;
(3) ethyl alcohol in supernatant is recycled, then gives back in the supernatant for harvest ethyl alcohol and sweetener is added, adjusts the PH of solution Value is 5.0-7.0, finally adds suitable quantity of water;
(4) preparation can be completed in filtering, sterilizing and filling;Wherein:The mass parts of each traditional Chinese medicinal components are in step 1:15 parts of curcuma zedoary- 75 parts, 12 parts -60 parts of radix paeoniae rubra, 12 parts -60 parts of hawthorn, 12 parts -60 parts of gynostemma pentaphylla, 12 parts -60 parts of Cassia occidentalis, giant knotweed 15 - 75 parts of part, 12 parts -60 parts of turmeric, 15 parts -75 parts of Radix Astragali, 15 parts -75 parts of matrimony vine.
2. the Chinese medicine preparation preparation method according to claim 1 for treating fatty liver and hyperlipidemia, feature exists In the addition for the ethyl alcohol that the mass percent concentration is 95% is 1.2-2 times of the gross mass of inspissated juice.
CN201410794632.XA 2014-12-18 A kind of Chinese medicine preparation preparation method for treating fatty liver and hyperlipidemia Expired - Fee Related CN104524448B (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101244157A (en) * 2007-02-15 2008-08-20 南京万舜源生物科技有限公司 Natural plants extract, preparation method and application thereof
CN102423413A (en) * 2012-01-04 2012-04-25 陈伯明 Medicament for treating hyperlipemia and fatty liver and preventing atherosclerosis as well as applications thereof
CN103705854A (en) * 2013-12-30 2014-04-09 郭兰春 Semen cassiae, fructus lycii and glossy privet fruit oral solution with functions of tonifying liver and reducing fat

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101244157A (en) * 2007-02-15 2008-08-20 南京万舜源生物科技有限公司 Natural plants extract, preparation method and application thereof
CN102423413A (en) * 2012-01-04 2012-04-25 陈伯明 Medicament for treating hyperlipemia and fatty liver and preventing atherosclerosis as well as applications thereof
CN103705854A (en) * 2013-12-30 2014-04-09 郭兰春 Semen cassiae, fructus lycii and glossy privet fruit oral solution with functions of tonifying liver and reducing fat

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
140味降脂中药治疗高脂血症的用药规律分析;钟周等;《湖南中医药大学学报》;20150131;第35卷(第1期);第64-66页 *

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CB03 Change of inventor or designer information

Inventor after: Geng Xiuli

Inventor after: Zhang Zhengchen

Inventor after: Ma Junjie

Inventor after: Wang Huamin

Inventor after: Lv Hongdi

Inventor after: Wang Xidong

Inventor after: Hao Shaojun

Inventor after: Sun Jianhua

Inventor after: Li Xianyu

Inventor after: Li Wenjun

Inventor before: Geng Xiuli

Inventor before: Lv Hongdi

Inventor before: Wang Xidong

Inventor before: Hao Shaojun

Inventor before: Sun Jianhua

Inventor before: Li Xianyu

Inventor before: Li Wenjun

Inventor before: Zhang Zhengchen

GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20180831

Termination date: 20201218