CN104524448A - Preparation method of traditional Chinese medicine preparation for treating fatty liver and hyperlipidaemia - Google Patents
Preparation method of traditional Chinese medicine preparation for treating fatty liver and hyperlipidaemia Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention provides a preparation method of a traditional Chinese medicine preparation for treating fatty liver and hyperlipidaemia. The preparation method comprises the following steps: (1) weighing curcuma zedoary, roots of common peony, hawthorn, gynostemma pentaphylla, cassia occidentalis, polygonum cuspidatum, turmeric, astragalus membranaceus and wolfberries in a certain mass; (2) decocting with water of which the weight is 6-8 times the total weight of the nine medicines three times, 40-50 minutes every time, filtering and combining decocted liquids, concentrating at 80 DEG C to obtain concentrated juice with the relative density of 1.15-1.30, then adding 95wt% of ethanol at room temperature, stirring while adding, and then putting for over 24 hours and extracting a supernate; and (3) recovering ethanol in the supernate and then adding a sweetening agent into the supernate when ethanol is recovered, adjusting the pH of the solution to 5.0-7.0 and finally adding a proper amount of water; and filtering, sterilizing and filling. The traditional Chinese medicine preparation prepared by the invention can be used for effectively treating fatty liver and hyperlipidaemia and is low in price.
Description
Technical field
The present invention relates to technical field of Chinese medicines, particularly relate to a kind of Chinese medicine preparation preparation method being used for the treatment of fatty liver and hyperlipemia.
Background technology
Fatty liver is one disease comparatively common in modern diseases.This sick incidence rate can reach about 50%, and focuses mostly in the male of 30 ~ 60 years old.Mild fatty liver is many without clinical symptoms.In, severe fatty liver has the performance of similar chronic hepatitis, can have inappetence, lassitude and weak, Nausea and vomiting, hepatic region or upper right abdomen dull pain, if can not get effective treatment finally can cause liver cirrhosis etc.Hyperlipidemia is a kind of affluenza of puzzlement modern, and it can strengthen the viscosity of blood, and harm blood circulation forms sclerosis of blood vessels.Hyperlipidemia can cause coronary heart disease, hypertension.Finally cause diabetes, sudden death heart disease, apoplexy etc.Up to the present, Western medicine there is no the active drug of control fatty liver and hyperlipidemia, though and have some treatment patient aspects Chinese medicine composition, but its curative effect of Chinese medicine composition utilizing current preparation method to prepare is not good enough, therefore, the existing method preparing Chinese medicine composition is needed to be improved, to improve curative effect.
Summary of the invention
The object of the invention is to the defect solving the existence of above-mentioned prior art, provide a kind of Chinese medicine preparation preparation method being used for the treatment of fatty liver and hyperlipemia, patient outcome is obvious in the Chinese medicine preparation utilizing this preparation method to prepare treatment.
Be used for the treatment of a Chinese medicine preparation preparation method for fatty liver and hyperlipemia, comprise the following steps:
(1) Rhizoma Curcumae of certain mass, Radix Paeoniae Rubra, Fructus Crataegi, Herb Gynostemmae Pentaphylli, Semen Cassiae, Rhizoma Polygoni Cuspidati, Rhizoma Curcumae Longae, the Radix Astragali, Fructus Lycii is taken;
(2) water getting 6-8 times of weight of the gross weight of the above nine taste Chinese medicines chosen decocts, decoct three times, boil 40-50 minute at every turn, filter and merge decoction liquor, at the temperature of 80 DEG C, be concentrated into the concentrated juice of relative density 1.15-1.30, then add the ethanol that mass percent concentration is 95% at ambient temperature, limit edged stirs, then place more than 24 hours, extract supernatant;
(3), by the ethanol in supernatant reclaim, then give in the supernatant having reclaimed ethanol and add sweeting agent, the pH value regulating solution is 5.0-7.0, finally adds suitable quantity of water;
(4), filter, sterilizing, fill can complete preparation.
Further, be used for the treatment of the Chinese medicine preparation preparation method of fatty liver and hyperlipemia as above, described mass percent concentration to be the addition of the ethanol of 95% the be 1.2-2 of the gross mass of concentrated juice doubly.
Further, be used for the treatment of the Chinese medicine preparation preparation method of fatty liver and hyperlipemia as above, in step 1, the mass parts of each Chinese medicinal components is: Rhizoma Curcumae 15 parts-75 parts, Radix Paeoniae Rubra 12 parts-60 parts, Fructus Crataegi 12 parts-60 parts, Herb Gynostemmae Pentaphylli 12 parts-60 parts, Semen Cassiae 12 parts-60 parts, Rhizoma Polygoni Cuspidati 15 parts-75 parts, 12 parts-60 parts, Rhizoma Curcumae Longae, the Radix Astragali 15 parts-75 parts, Fructus Lycii 15 parts-75 parts.
The Chinese medicine preparation preparation method being used for the treatment of fatty liver and hyperlipemia provided by the invention, can effectively treat fatty liver and hyperlipemia, and low price.
Detailed description of the invention
For making the object, technical solutions and advantages of the present invention clearly, below technical scheme in the present invention be clearly and completely described, obviously, described embodiment is the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
The Chinese medicine preparation preparation method for the treatment of fatty liver of the present invention and hyperlipemia is as follows:
(1) Rhizoma Curcumae 15 parts-75 parts is chosen, Radix Paeoniae Rubra 12 parts-60 parts, Fructus Crataegi 12 parts-60 parts, Herb Gynostemmae Pentaphylli 12 parts-60 parts, Semen Cassiae 12 parts-60 parts, Rhizoma Polygoni Cuspidati 15 parts-75 parts, 12 parts-60 parts, Rhizoma Curcumae Longae, the Radix Astragali 15 parts-75 parts, Fructus Lycii 15 parts-75 parts;
(2) water getting 6-8 times of weight of the gross weight of the above nine taste Chinese medicines chosen decocts, decoct three times, boil 40-50 minute at every turn, filter and merge decoction liquor, be concentrated into the concentrated juice of relative density 1.15-1.30 (80 DEG C), add the ethanol that mass percent concentration is 95% more at ambient temperature, the addition of described ethanol is 1.2-2 times of the gross weight of concentrated juice, and limit edged stirs, after interpolation, place more than 24 hours, extract supernatant;
(3), by the ethanol remained in supernatant reclaim, give in the supernatant having reclaimed ethanol and add sweeting agent, the pH value regulating solution is 5.0-7.0, and finally adding water, it is standing to stir evenly;
(4), filter, sterilizing, fill can complete preparation.
Below the Chinese medicine preparation treatment curative effect by adopting preparation method of the present invention to prepare:
Example 1:
Name: so-and-so sex tall: female's age: 61 years old address: Xinxiang Ma little Ying
Patient occurs that aphasia, left upper extremity are unable and is admitted to hospital, with dizziness, cardiopalmus, poor appetite.Human health screening, blood pressure 170/100mmhg, sanity, aphasia, LC face tongue paralysis, white and greasy fur, Cervical Vessels is not heard and exception.Muscular strength 4 grades under upper left, hypomyotonia, left side pathology levies the positive.Head CT shows multiple infarct, and blood fat shows T-CHOL 7.28mol/L, triglyceride 2.19mol/L, HDL-C 1.22mol/L, low density cholesterol 4.70mol/L.Enter section's diagnosis: multiple infarct, hyperlipemia.After entering section, routine is given to thromboembolism preventing, is improved the symptomatic treatments such as brain blood circulation, add simultaneously and use oral liquid of the present invention 20ml/ time, every day 3 times is oral, within 20 days, checks blood fat afterwards and shows 3.87mol/L, triglyceride 1.5mol/L, HDL-C 1.92mol/L, low density cholesterol 2.28mol/L, obviously improves when being comparatively admitted to hospital, evident in efficacy, advise low fat diet at ordinary times, continue oral maintaining treatment.
Example 2:
Name: Yang's sex: man's age: 58 years old address: Xin electricity community, Xinxiang patient occurs that burst is dizzy, and left side myasthenia of limbs is admitted to hospital, with dizziness, cardiopalmus, poor appetite, the sick official of existing coronary heart disease, atrial fibrillation.Human health screening, blood pressure 150/90mmhg, sanity, spirit is poor, and speech is fluent, and body of the tongue is slightly dark, white and greasy fur, and Cervical Vessels is not heard and exception.Muscular strength 5 grades under upper left, hypomyotonia, left side pathology levies the positive.Head MRL shows multiple infarct, and blood fat shows T-CHOL 6.15mol/L, triglyceride 2.95mol/L, HDL-C 0.75mol/L, low density cholesterol 4.36mol/L.Enter section's diagnosis: cerebral infarction, hyperlipemia.After entering section, routine is given to thromboembolism preventing, is improved the symptomatic treatments such as brain blood circulation, add simultaneously and use oral liquid of the present invention 20ml/ time, every day 3 times is oral, within 20 days, checks blood fat afterwards and shows 3.51mol/L, triglyceride 0.58mol/L, HDL-C 2.12mol/L, low density cholesterol 1.78mol/L, obviously improves when being comparatively admitted to hospital, evident in efficacy, advise low fat diet at ordinary times, continue oral maintaining treatment.
Example 3:
Name: the Meng so-and-so sex: female's age: 60 years old address: Xinxiang West Platform head
There is left limb hemiplegia 2 weeks in patient, abdominal distention, poor appetite are admitted to hospital for 10 days, previously obesity, 10 years hypertension officials, human health screening, body weight 80KG, blood pressure 164/102mmhg, sanity, spirit is poor, aphasia, abdominal distention, appetite still can, without feel sick tending to vomit, time feel nose heave, body of the tongue is slightly dark, and tongue is greasy in vain, stringy and hesitant pulse, neck is soft, and muscular strength 3 grades under upper right, right side pathology levies feminine gender.Head MRL shows multiple infarct, brain atrophy, and blood fat shows T-CHOL 8.12mol/L, triglyceride 5.26mol/L, HDL-C 0.79mol/L, low density cholesterol 5.53mol/L.Enter section's diagnosis: cerebral infarction, hyperlipemia.After entering section, routine gives thromboembolism preventing, improves the symptomatic treatments such as brain blood circulation, add simultaneously and use oral liquid of the present invention 20ml/ time, every day 3 times is oral, within 20 days, checks blood fat afterwards and shows 5.03mol/L, triglyceride 2.58mol/L, HDL-C 1.52mol/L, low density cholesterol 2.38mol/L, obviously improves when being comparatively admitted to hospital, evident in efficacy, advise low fat diet at ordinary times, continue oral maintaining treatment.
Example 4:
Name: so-and-so sex of Xu: man's age: 55 years old
Patient occurred dizzy, weak before last week, right hypochondriac region is uncomfortable, and dull pain increases the weight of to be admitted to hospital gradually, with inappetence, and abdominal distention, belch, hepatic region distension; Previously there is hypertension medical history 10 years; History of coronary heart disease 5 years.Have a medical check-up, 160/95mmhg, mind is clear, and spirit is poor, and chronic face, auscultation of lung no abnormality seen, heart circle expands to left down, heart rate 70 beats/min.A2>P2, abdominal tympanites, liver palpation of spleen owe satisfied, and Murphy levies feminine gender, has no liver distension of jugular vein.Other check: electrocardio illustrates: deficiency myocardial blood supply, ultrasonic prompting: severe fatty liver; Chemical examination blood fat, T-CHOL 7.2mmol/L, triglyceride 4.8mmol/L, low density lipoprotein, LDL 0.86mmol/L.Liver function: glutamic oxaloacetic transaminase, GOT 51mmol/L, glutamate pyruvate transaminase 78mmol/L, hepatitis B surface antigen (-) property, ultrasonic prompting: severe fatty liver; Clinical diagnosis: 1 fatty liver (severe) 2, hyperlipidemia 3, hypertension 2 grade 4, coronary heart disease; The following Therapeutic Method of main application, blood fat reducing, blood pressure lowering, coronary artery dilator blood vessel, waits symptomatic treatment, adds simultaneously and uses oral liquid of the present invention 20ml/ time, every day 3 times; Symptom obviously alleviates, and blood pressure stabilization is normal, and the electrocardiogram degree of ischemia amount of showing alleviates, and the aobvious amount of blood fat declines, significantly effectively reach clinical cure standard, the 23rd day check blood fat, T-CHOL 4.8mmol/L, triglyceride 1.5mmol/L, low-density albumen 3.21mmol/L, high-density protein 1.98mmol/L.Advise patient's low fat diet, moderate exercise, adhere to taking medicine, consolidate curative effect.
Last it is noted that above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of various embodiments of the present invention technical scheme.
Claims (3)
1. be used for the treatment of a Chinese medicine preparation preparation method for fatty liver and hyperlipemia, it is characterized in that, comprise the following steps:
(1) Rhizoma Curcumae of certain mass, Radix Paeoniae Rubra, Fructus Crataegi, Herb Gynostemmae Pentaphylli, Semen Cassiae, Rhizoma Polygoni Cuspidati, Rhizoma Curcumae Longae, the Radix Astragali, Fructus Lycii is taken;
(2) water getting 6-8 times of weight of the gross weight of the above nine taste Chinese medicines chosen decocts, decoct three times, boil 40-50 minute at every turn, filter and merge decoction liquor, at the temperature of 80 DEG C, be concentrated into the concentrated juice of relative density 1.15-1.30, then add the ethanol that mass percent concentration is 95% at ambient temperature, limit edged stirs, then place more than 24 hours, extract supernatant;
(3), by the ethanol in supernatant reclaim, then give in the supernatant having reclaimed ethanol and add sweeting agent, the pH value regulating solution is 5.0-7.0, finally adds suitable quantity of water;
(4), filter, sterilizing, fill can complete preparation.
2. the Chinese medicine preparation preparation method being used for the treatment of fatty liver and hyperlipemia according to claim 1, is characterized in that, described mass percent concentration to be the addition of the ethanol of 95% the be 1.2-2 of the gross mass of concentrated juice doubly.
3. the Chinese medicine preparation preparation method being used for the treatment of fatty liver and hyperlipemia according to claim 1, it is characterized in that, in step 1, the mass parts of each Chinese medicinal components is: Rhizoma Curcumae 15 parts-75 parts, Radix Paeoniae Rubra 12 parts-60 parts, Fructus Crataegi 12 parts-60 parts, Herb Gynostemmae Pentaphylli 12 parts-60 parts, Semen Cassiae 12 parts-60 parts, Rhizoma Polygoni Cuspidati 15 parts-75 parts, 12 parts-60 parts, Rhizoma Curcumae Longae, the Radix Astragali 15 parts-75 parts, Fructus Lycii 15 parts-75 parts.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410794632.XA CN104524448B (en) | 2014-12-18 | A kind of Chinese medicine preparation preparation method for treating fatty liver and hyperlipidemia |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410794632.XA CN104524448B (en) | 2014-12-18 | A kind of Chinese medicine preparation preparation method for treating fatty liver and hyperlipidemia |
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| Publication Number | Publication Date |
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| CN104524448A true CN104524448A (en) | 2015-04-22 |
| CN104524448B CN104524448B (en) | 2018-08-31 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106421550A (en) * | 2016-11-30 | 2017-02-22 | 上海市同仁医院 | Traditional Chinese medicine composition for treating fatty liver and preparation method of traditional Chinese medicine composition for treating fatty liver |
| CN106581589A (en) * | 2017-02-22 | 2017-04-26 | 中国中医科学院 | Pharmaceutical composition for treating HIV hyperlipemia and preparation method thereof |
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| CN101244157A (en) * | 2007-02-15 | 2008-08-20 | 南京万舜源生物科技有限公司 | Natural plants extract, preparation method and application thereof |
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| CN101244157A (en) * | 2007-02-15 | 2008-08-20 | 南京万舜源生物科技有限公司 | Natural plants extract, preparation method and application thereof |
| CN102423413A (en) * | 2012-01-04 | 2012-04-25 | 陈伯明 | Medicament for treating hyperlipemia and fatty liver and preventing atherosclerosis as well as applications thereof |
| CN103705854A (en) * | 2013-12-30 | 2014-04-09 | 郭兰春 | Semen cassiae, fructus lycii and glossy privet fruit oral solution with functions of tonifying liver and reducing fat |
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| 钟周等: "140味降脂中药治疗高脂血症的用药规律分析", 《湖南中医药大学学报》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106421550A (en) * | 2016-11-30 | 2017-02-22 | 上海市同仁医院 | Traditional Chinese medicine composition for treating fatty liver and preparation method of traditional Chinese medicine composition for treating fatty liver |
| CN106581589A (en) * | 2017-02-22 | 2017-04-26 | 中国中医科学院 | Pharmaceutical composition for treating HIV hyperlipemia and preparation method thereof |
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