CN115400175B - Traditional Chinese medicine composition for treating chronic renal failure - Google Patents
Traditional Chinese medicine composition for treating chronic renal failure Download PDFInfo
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- CN115400175B CN115400175B CN202211086171.1A CN202211086171A CN115400175B CN 115400175 B CN115400175 B CN 115400175B CN 202211086171 A CN202211086171 A CN 202211086171A CN 115400175 B CN115400175 B CN 115400175B
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Abstract
The invention relates to a traditional Chinese medicine composition for treating chronic renal failure, which comprises oral uremic toxin detoxification powder and external kidney Hei paste, wherein the uremic toxin detoxification powder comprises the following medicinal materials in parts by weight: 15 parts of medicinal lychee seed, 5 parts of cordyceps militaris or cordyceps sinensis, wherein the kidney Hei paste comprises traditional Chinese medicine powder consisting of the following medicinal materials in parts by weight: 720 parts of safflower, 450 parts of pseudo-ginseng, 480 parts of rheum officinale, 720 parts of frankincense, 720 parts of myrrh, 600 parts of sappan wood, 600 parts of fructus Gardeniae, 450 parts of eupolyphaga, 480 parts of native copper, 300 parts of ligusticum wallichii, 360 parts of Chinese angelica, 360 parts of radix clematidis, 480 parts of rhizoma drynariae and 480 parts of amur corktree bark, wherein the kidney Hei plaster is applied to kidney Shu acupoint and surrounding skin of the waist when in use.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, and in particular belongs to a traditional Chinese medicine composition for treating chronic renal failure.
Background
It is counted that the disease is diabetes mellitus patients with 10-20 years. Clinical renal lesions occur in 50% of all ages. Diabetics die from renal failure in about 5% -15%. Diabetic renal failure has no great significance in kidney replacement. If the life is to be prolonged, the only clinical approach is "kidney dialysis", which is the so-called "kidney washing" by the common people. At present, almost all public hospitals in China are provided with a dialysis department, and many private clinics are also provided with a dialysis department. The number of patients is not too small, the true number is not published, and the patients are believed to be feelings of confusion.
According to Chen Guowei, the main code "modern emergency internal science" (page 358), shows: chronic renal failure dialysis (renal wash) indication:
(1) BUN (urea nitrogen) is more than or equal to 28.6mmol/L, (2) blood creatinine is more than or equal to 530.4umol/L, (3) Ccr is close to 10ml/min, and (4) serum potassium is more than or equal to 6.5mmol/L. (5) Has obvious water sodium retention or nervous system comprehensive complications.
Basic diagnosis and treatment Specification of common diseases in Guangdong province divides the clinical manifestations of diabetic nephropathy into phases 5:
stage I: in the early stages of diabetic nephropathy, only clinical manifestations of diabetes are seen.
Stage II: during microalbuminuria, the excretion rate of urine protein after activity is 20-200ug/min (or 30-300mg/24 h).
Stage III: early diabetic nephropathy, urinary protein excretion rate of more than 200ug/min (or 300mg/24 h), urinary protein excretion rate of more than 0.5g/24h, and mild hypertension.
Stage IV: clinically diabetic nephropathy, there is significant uroproteinuria, which is manifested as nephrotic syndrome.
V phase: end stage renal failure.
After diabetes enters the period of renal function impairment, some people progress very rapidly. Renal damage was not found until recently, and developed into uremia in less than a few months. At this time, no matter the Western medicine is, the curative effect is not ideal, and only kidney replacement or kidney dialysis can be performed.
The traditional Chinese medicine considers that uremia is a syndrome group of serious metabolic disturbance in various aspects of human body caused by renal excretion and regulation dysfunction due to kidney function weakness. The pathogenesis of the kidney disease is that the kidney function is gradually declined and spleen qi is deficient and the damp toxin is not excreted due to the chronic failure or the mistreatment of the kidney disease. The reverse and dry-up can lead to dizziness. The symptoms of dark complexion, frequent vomiting, dysphoria, coma, scanty stool, elevated blood pressure, wiry and thready pulse or thready pulse. This deficiency of the body resistance and excessive pathogenic factors, with the syndrome of yin-yang separation, may cause immediate death if there is no effective measure.
According to clinical observation, kidney function is basically progressive after being damaged, but the progress speed is fast and slow, and self-healing is almost impossible.
A drug or method is developed that can prevent or delay entry into end-stage renal failure prior to uremia. Has great clinical significance.
Disclosure of Invention
The invention aims to overcome the defects of the prior art, and provides a traditional Chinese medicine composition for treating chronic renal failure, which can effectively prevent or delay entering end-stage renal failure by adopting a method of strengthening spleen and tonifying kidney and activating blood circulation to remove blood stasis in traditional Chinese medicine.
In order to achieve the above purpose, the technical scheme provided by the invention is as follows: the provided traditional Chinese medicine composition for treating chronic renal failure comprises an oral detoxication powder for treating chronic renal failure and a kidney Hei plaster for external use, wherein the detoxication powder for treating chronic renal failure comprises the following medicinal materials in parts by weight: 15 parts of medicinal lychee seed, 5 parts of cordyceps militaris or cordyceps sinensis, wherein the kidney Hei paste comprises traditional Chinese medicine powder consisting of the following medicinal materials in parts by weight: 720 parts of safflower, 450 parts of pseudo-ginseng, 480 parts of rheum officinale, 720 parts of frankincense, 720 parts of myrrh, 600 parts of sappan wood, 600 parts of fructus Gardeniae, 450 parts of eupolyphaga, 480 parts of native copper, 300 parts of ligusticum wallichii, 360 parts of Chinese angelica, 360 parts of radix clematidis, 480 parts of rhizoma drynariae and 480 parts of amur corktree bark, wherein the kidney Hei plaster is applied to kidney Shu acupoint and surrounding skin of the waist when in use.
Preferably, the uremic toxin detoxification powder is taken orally by boiling soup together with pig waists and rice washing water and removing residues.
Preferably, the kidney Hei plaster consists of a hot melt adhesive matrix, chinese medicinal powder and plaster auxiliary medicinal powder.
Preferably, the kidney Hei plaster is prepared from a hot melt adhesive matrix, chinese medicinal powder and plaster auxiliary material medicinal powder according to 1000: 300-350:100.
Preferably, the plaster auxiliary material powder consists of one or more of penetrant azone powder, far infrared ceramic powder, pain relieving powder, antiallergic powder and heat generating agent.
Preferably, the plaster auxiliary material medicinal powder comprises penetrant azone powder, far infrared ceramic powder, pain relieving powder, antiallergic powder and a heat generating agent according to the proportion of 20-40: 30-50: 10-30:10-20:1-3.
Preferably, the heating agent is capsaicin heating agent or oil vanilla heating agent.
Preferably, 1000g of hot melt adhesive matrix is heated and melted by the kidney Hei plaster, the melting temperature is within the range of 120-140 ℃ and cannot exceed 150 ℃ at most, the mixture is stirred while being melted, the mixture is fluidized after being completely melted, then the mixture is added with Chinese medicinal powder and plaster auxiliary material medicinal powder, and the mixture is covered with a separation film and flattened after being uniformly stirred.
The invention has the advantages that: provides a traditional Chinese medicine composition for treating chronic renal failure, which adopts the methods of strengthening spleen and tonifying kidney, activating blood and removing stasis in traditional Chinese medicine and can effectively prevent or delay uremia.
Oral powder for detoxication of urinary toxin
According to the theory of traditional Chinese medicine, kidneys are the congenital origin, and the residence of water and fire. The kidney yin and yang balance, yang qi transforming into water and fluid, and the body balance. If kidney yang is deficient and qi fails to transform water, water is flooded, and edema is caused around the body; heart-over lung-shot, palpitation and asthma; waist is the house of kidney and kidney yang deficiency, lumbago; when the fire of the gate is weakened, the limbs are not warm. The recipe of treating the syndrome of shaoyin cold in Shang Han Lun in Sheng Zhang Zhong Jing (Shang Han Lun) in Zhen Wu Shangnai is a representative recipe for treating edema due to kidney-yang deficiency by the following medical practitioner. In the recipe, fu Zi is the key herb for warming kidney, restoring yang and rescuing from adverse reaction. And the amount thereof is more than three times.
The pathogenesis of chronic nephritis is the deficiency of the spleen and kidney. Spleen qi deficiency can cause failure of transportation and transformation. On the one hand, qi and blood are not enough, qi deficiency causes weak blood circulation, blood circulation is slow, blood stasis is caused for a long time, and qi deficiency further causes yang deficiency, so that internal cold is generated. Cold congealing can also form blood stasis syndrome. On the other hand, spleen deficiency causes internal retention of water-dampness. Qi deficiency of the kidney leads to dysfunction of kidney qi. The kidney is a malfunction of keeping its essence and purging its coarse (under the Chinese yam strip of Shen Long Ben Cao Jing Shu), so that the toxicant such as coarse stays in the kidney collaterals. So as to block the kidney collaterals. Dampness and blood stasis etc. to dispel heat and toxic materials. Therefore, the pathogenesis of chronic nephritis is spleen-kidney qi deficiency and damp-heat stasis toxin internal arrest. Therefore, the decoction is treated by tonifying yang and restoring five decoction (medical correction prescription) with the effects of tonifying qi and activating blood. The medical staff of the past generations can obtain satisfactory effects. The dosage of the qi-tonifying medicine astragalus root in the prescription is 1-4 for each dose.
It can be seen that aconite root and astragalus root are important herbs for treating chronic nephritis by the traditional Chinese medicine.
Radix Aconiti lateralis Preparata is the lateral root of Aconitum carmichaeli (Linn.) kuntze belonging to Ranunculaceae, and has the flavor of da Xin and strong heat property. The main toxic component is aconitine. In clinical practice, fu Zi should be cooked. Decoction containing radix Aconiti lateralis has to be decocted for at least one hour. It is considered to have the key actions of restoring yang, rescuing adverse qi, dispelling cold and relieving pain.
The semen litchi is dry mature seed of fructus litchi of Sapindaceae. Belongs to pungent and warm medicinal materials, and enters kidney channels and liver channels to be cool and bitter in taste. The product has the effects of dispersing stagnated liver qi, promoting qi circulation, resolving hard mass, dispelling cold and relieving pain. Sometimes it is very effective to reach the effect of standing a pole. And the biggest characteristic is almost innocuity.
The treatment course is longer in consideration of chronic kidney function impairment. The lychee seeds with small toxicity and similar functions are used for replacing the aconite with larger toxicity, so that the curative effect is quite ideal.
Astragalus root, radix astragali, has the documented effect of (1) strengthening, so-called "tonifying qi", possibly associated with its action of sex hormones and action of stimulating the central nervous system. (2) Diuretic: however, the effective dosage range is smaller, and the dosage is too small or too large to reduce the urine volume. (3) Anti-nephritis: has certain anti-inflammatory effect on experimental nephritis, and is particularly helpful in proteinuria removal. (4) Depressurization: animal experiments prove that the antihypertensive effect can be related to dilating blood vessels.
Cordyceps militaris has sweet taste, and can nourish lung and kidney, stop bleeding, resolve phlegm, and treat senile weakness, anemia and weakness. Zhao Xuemin in "Ben Cao gang mu Mi Yi": cordyceps militaris can treat deficiency and impairment. The clinical medical effect of the Cordyceps militaris is not inferior to that of Cordyceps militaris (the original prescription is Cordyceps militaris, and the Cordyceps militaris is used for fixation and modification because of the expensive medicine), and the Cordyceps militaris contains rich cordycepic acid, cordycepin, ergosterol and the like, and has the functions of expanding trachea, calming, resisting various bacteria and reducing blood pressure. The cordycepic acid can also be used for treating cerebral thrombosis, cerebral embolism, vasospasm, cerebral hemorrhage, etc., and promoting metabolism and urination. Cordyceps polysaccharide can improve liver detoxification ability and protect liver.
The cordyceps militaris with better functions is used for replacing the astragalus.
The lychee seed and the cordyceps militaris are adopted as main medicines of the uremic antidote, and the practice proves that the effect is obvious.
It should be noted here that detoxification powder cannot be decocted with water for oral administration like general traditional Chinese medicine, and the pen person tries to decoction with water for oral administration, so that the result is basically no curative effect, and rice washing water and pig waists must be added for steaming and eating together for effective treatment. The reason is not elucidated yet. Whether the traditional Chinese medicine is related to certain vitamins in rice washing water and certain active substances in pig waists or not, whether the traditional Chinese medicine is in a shape supplementing form or not is considered later, and clinical observation shows that the traditional Chinese medicine has obvious reducing effect on urea nitrogen and creatinine after three times of administration.
Kidney Hei plaster:
in chronic renal failure (CFR), modern researches have shown that in chronic renal failure, blood viscosity is increased, blood is easily coagulated, and blood fat is increased, so that blood flow is slowed down, and the secondary glomerular filtration rate is reduced. The fibrinolytic system activity is reduced and fibrin is deposited in glomerular capillaries. Tissue hypoxia is easy to generate microvascular embolism and microcirculation disturbance, so that the kidney function is reduced, rheum officinale can improve amino acid metabolism, inhibit proliferation of mesangial cells, resist damage of kidney growth promoting factors to kidney tissues, inhibit tubular metabolism and promote excretion of intestinal ammoniated metabolites; the Chinese medicine for nourishing blood, promoting blood circulation, reducing blood platelet aggregation, reducing blood viscosity and K value, dilating blood vessel and increasing kidney blood flow has great effect on promoting blood circulation and removing blood stasis, such as Chinese angelica, hemlock parsley, safflower, pseudo-ginseng, clematis root, wood louse, drynaria rhizome, etc. It also has effects in nourishing liver and kidney, nourishing essence and blood, and improving overall condition.
Chronic nephritis is not a single disease, and its pathology and prognosis involve multiple systems, clinical manifestations, and pathological changes are also profound, cold and heat, and deficiency and excess are complicated. Optionally, exogenous pathogenic factors, damp-heat, etc. may be added, and cortex Phellodendri may be added to clear damp-heat in lower-jiao.
It is stated here that chronic nephritis approaches the end stage, especially in diabetic renal patients, who are already very weak. Kidney function is already poor. A large amount of oral medication may even further impair renal function. Because the oral medicine is no matter the Chinese medicine and the western medicine, the oral medicine is generally absorbed by intestinal tracts, detoxified by liver and excreted by kidneys mostly.
Because of the specific location of the kidneys, it is located on both sides of the spine, in close proximity to the abdominal posterior wall and ex vivo behind the peritoneum. Therefore, part of medicines can be designed to be used externally, so that the medicines can act on the kidneys without increasing the burden of the kidneys, and most of medicines for promoting blood circulation and removing blood stasis are designed to be used as medicine ways of black plaster.
The most commonly used transdermal agents in medicine today are dimethyl sulfoxide and azone. Dimethyl sulfoxide is an inert liquid, can dissolve various effective components of traditional Chinese medicines without damaging the components, and can deliver the medicines to deep tissues of a human body. Azone has stronger penetrability than dimethyl sulfoxide by 5-10 times, but is more active than dimethyl sulfoxide, and has no adverse effect on the treatment effect. Has obvious curative effect.
Drawings
FIG. 1 is an assay report of case 1;
FIG. 2 is an assay report of case 1;
FIG. 3 is an assay report of case 2;
FIG. 4 is a case 2 assay report;
FIG. 5 is a case 3 assay report;
FIG. 6 is an assay report of case 3;
FIG. 7 is an assay report of case 4;
FIG. 8 is an assay report of case 4;
FIG. 9 is a member of a physician association in the inventor's global license;
Detailed Description
The invention is further described below with reference to the accompanying drawings. The following examples are only for more clearly illustrating the technical aspects of the present invention, and are not intended to limit the scope of the present invention.
Example 1: a Chinese medicinal composition for treating chronic renal failure comprises an oral detoxication powder for treating chronic renal failure and a kidney Hei plaster for external use, wherein the detoxication powder for treating chronic renal failure comprises the following medicinal materials in parts by weight: 15 parts of medicinal lychee seed, 5 parts of cordyceps militaris or cordyceps sinensis, wherein the kidney Hei paste comprises traditional Chinese medicine powder consisting of the following medicinal materials in parts by weight: 720 parts of safflower, 450 parts of pseudo-ginseng, 480 parts of rheum officinale, 720 parts of frankincense, 720 parts of myrrh, 600 parts of sappan wood, 600 parts of fructus Gardeniae, 450 parts of eupolyphaga, 480 parts of native copper, 300 parts of ligusticum wallichii, 360 parts of Chinese angelica, 360 parts of radix clematidis, 480 parts of rhizoma drynariae and 480 parts of amur corktree bark, wherein the kidney Hei plaster is applied to waist Shenshu acupoint and surrounding skin when in use; the uremic toxin detoxification powder is taken orally by boiling soup together with pig waist and rice washing water and removing residues.
The kidney Hei plaster consists of 1000g of hot melt adhesive matrix, 300-350 g of traditional Chinese medicine powder and 100g of plaster auxiliary material powder. Heating and melting 1000g of hot melt adhesive matrix, wherein the melting temperature is not higher than 150 ℃ at the highest within the range of 120-140 ℃, stirring while melting, turning into a fluidized state after complete melting, adding the traditional Chinese medicine powder and the plaster auxiliary material powder, uniformly stirring, covering a separation film in the middle of plaster cloth, and flattening.
The plaster auxiliary material medicinal powder consists of one or more of penetrant azone powder, far infrared ceramic powder, pain relieving powder, antiallergic powder and a heating agent, wherein the heating agent is capsaicin heating agent or oil vanilla heating agent.
Example 2: a Chinese medicinal composition for treating chronic renal failure comprises an oral detoxication powder for treating chronic renal failure and a kidney Hei plaster for external use, wherein the detoxication powder for treating chronic renal failure comprises the following medicinal materials in parts by weight: 15 parts of medicinal lychee seed, 5 parts of cordyceps militaris or cordyceps sinensis, wherein the kidney Hei paste comprises traditional Chinese medicine powder consisting of the following medicinal materials in parts by weight: 720 parts of safflower, 450 parts of pseudo-ginseng, 480 parts of rheum officinale, 720 parts of frankincense, 720 parts of myrrh, 600 parts of sappan wood, 600 parts of fructus Gardeniae, 450 parts of eupolyphaga, 480 parts of native copper, 300 parts of ligusticum wallichii, 360 parts of Chinese angelica, 360 parts of radix clematidis, 480 parts of rhizoma drynariae and 480 parts of amur corktree bark, wherein the kidney Hei plaster is applied to waist Shenshu acupoint and surrounding skin when in use; the uremic toxin detoxification powder is taken orally by boiling soup together with pig waist and rice washing water and removing residues.
The kidney Hei plaster consists of 1000g of hot melt adhesive matrix, 300-350 g of traditional Chinese medicine powder and 100g of plaster auxiliary material powder. Heating and melting 1000g of hot melt adhesive matrix, wherein the melting temperature is not higher than 150 ℃ at the highest within the range of 120-140 ℃, stirring while melting, turning into a fluidized state after complete melting, adding the traditional Chinese medicine powder and the plaster auxiliary material powder, uniformly stirring, covering a separation film in the middle of plaster cloth, and flattening.
The plaster auxiliary material medicinal powder comprises penetrant azone powder, far infrared ceramic powder, pain relieving powder, antiallergic powder and a heat generating agent according to the proportion of 20-40: 30-50: 10-30:10-20:1-3. The heating agent is capsaicin heating agent or oil vanilla heating agent.
Example 3:
the inventor Li Yiqian, now a physician in the middle of the planner city of Guangdong, also a member of the medical community in the global license, healed multiple patients with the present formulation, and the following 4 cases were treated by the method of the present invention.
Case 1
Qin Mou Male, 48 years (2015 years)
2015 12 month 9 day chemical experiment report (see fig. 1): urea nitrogen 19.82, creatinine 834.32.
The treatment with the method of the present invention was started on day 2015, 12 and 11.
2015 12 month 14 day chemical experiment report (see fig. 2): urea nitrogen 18.45, creatinine 649.
After 3 days of treatment, creatinine was reduced by 200 units.
Case 2
Chen Mou Male 46 years (2015)
Hospital exam at 11 months 29 2015 (see fig. 3), urea nitrogen 20.77, creatinine 354, and then begin to listen to the orders and receive treatment with the method of the present invention.
Hospital examination of 2016, 1 and 8 days, urea nitrogen 17.14, creatinine 403 and total protein 52.7.
2016, 2 months, 1 day (see fig. 4): urea nitrogen 16.80, creatinine 442.
Case 3
Qin Mou Male, 68 years old
Hospital query 2/5/2020 (see fig. 6): urea nitrogen 11.54, creatinine 212, total protein 48.6 (systemic edema).
Hospital hospitalization for 3 months and 17 days: urea nitrogen 11.35, creatinine 211.62.
Hospital check 5/29/2020: urea nitrogen 15.32, creatinine 234.9, total protein 54.8.
After which the treatment with the method of the invention is started.
Recheck 9/8: urea nitrogen 8.20, creatinine 158, total protein 57.3.
2021, 1-4 (see fig. 5): urea nitrogen 7.87, creatinine 178, total protein 61.9 (edema disappeared).
The treatment is still under treatment until now, the urea nitrogen is kept within 10 points, and the creatinine is not more than 200, so that normal life and work can be realized.
Case 4
He Mou Male, 71 years (2020)
There is a history of diabetes for more than 10 years, and in recent years, insulin injection has been used for hypoglycemic treatment.
The disease is characterized in that urine is found to be 555mg/24h after the concave edema below the knee joint of the double lower limbs is found in the last half month before 18 days in 3 months in 2020, urine glucose++, urine protein+ are found in hospitals, and the disease is planned to be diagnosed in the period III of diabetic nephropathy. Thereafter, treatment with the method of the present invention was started, and the study was repeated 6 by 6 months 2020 (see FIG. 7): urine sugar+, urine protein (+/-), 10mg/24h, and the rest are all normal; renal function examination, blood glucose 10.16, urea nitrogen, creatinine, etc. all normal range, edema disappeared, had been basically healed. Continuing to consolidate the treatment until the treatment is stopped at the end of 6 months. After that, twenty days of treatment are consolidated every three months to half a year, so that no special discomfort exists.
Finally, it should be noted that: it is apparent that the above examples are only illustrative of the present invention and are not limiting of the embodiments. Other variations or modifications of the above teachings will be apparent to those of ordinary skill in the art. It is not necessary here nor is it exhaustive of all embodiments. And obvious variations or modifications thereof are contemplated as falling within the scope of the present invention.
Claims (6)
1. The traditional Chinese medicine composition for treating chronic renal failure is characterized by comprising oral uremic detoxification powder and external kidney Hei paste, wherein the uremic detoxification powder is prepared from the following medicinal materials in parts by weight: 15 parts of medicinal lychee seed, 5 parts of cordyceps militaris or cordyceps sinensis, wherein the kidney Hei paste is traditional Chinese medicine powder prepared from the following medicinal materials in parts by weight: 720 parts of safflower, 450 parts of pseudo-ginseng, 480 parts of rheum officinale, 720 parts of frankincense, 720 parts of myrrh, 600 parts of sappan wood, 600 parts of fructus Gardeniae, 450 parts of eupolyphaga, 480 parts of native copper, 300 parts of ligusticum wallichii, 360 parts of Chinese angelica, 360 parts of radix clematidis, 480 parts of rhizoma drynariae and 480 parts of amur corktree bark, wherein the kidney Hei plaster is applied to waist Shenshu acupoint and surrounding skin when in use; the uremic toxin detoxification powder is taken orally by boiling soup together with pig waist and rice washing water and removing residues.
2. The traditional Chinese medicine composition for treating chronic renal failure according to claim 1, wherein the kidney Hei plaster consists of a hot melt adhesive matrix, traditional Chinese medicine powder and plaster auxiliary material powder.
3. The traditional Chinese medicine composition for treating chronic renal failure according to claim 2, wherein the kidney Hei plaster is prepared from a hot melt adhesive matrix, traditional Chinese medicine powder and plaster auxiliary material powder according to a proportion of 1000: 300-350:100.
4. The traditional Chinese medicine composition for treating chronic renal failure according to claim 3, wherein the plaster auxiliary material powder consists of one or more of penetrant azone powder, far infrared ceramic powder, pain relieving powder, antiallergic powder and exothermic agent.
5. The composition of claim 4, wherein the exothermic agent is capsaicin exothermic agent or oil vanilla exothermic agent.
6. The composition of claim 3, wherein the kidney Hei plaster is prepared by melting 1000g of the hot melt adhesive matrix by heating at a temperature of 120-140 deg.c, stirring while melting, turning to a fluidized state after complete melting, adding the powder of the Chinese medicine and the powder of the plaster auxiliary material, stirring uniformly, covering with a isolating film, and flattening.
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国家中医药管理局组织.《全国名老中医药专家传承工作室建设成果概览 第1辑》.中国中医药出版社,2016,第218页右栏第2段. * |
慢性肾功能衰竭中药灌肠的临床观察及护理;唐雅文;护理学杂志;-(05);第298页 * |
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