CN104521999A - Synergistic acaricidal composition containing tebufenpyrad and ivermectin - Google Patents
Synergistic acaricidal composition containing tebufenpyrad and ivermectin Download PDFInfo
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- CN104521999A CN104521999A CN201410822856.7A CN201410822856A CN104521999A CN 104521999 A CN104521999 A CN 104521999A CN 201410822856 A CN201410822856 A CN 201410822856A CN 104521999 A CN104521999 A CN 104521999A
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- tebufenpyrad
- ivermectin
- ivermectin hcl
- mite
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Abstract
The invention relates to a synergistic acaricidal composition containing tebufenpyrad and ivermectin. The weight part ratio of the tebufenpyrad to the ivermectin is (20 to 1)-(1 to 20), and the sum of the weight of the tebufenpyrad and the ivermectin accounts for 5-80% of the weight of the acaricidal composition. The two active ingredients are compounded to achieve an obvious synergistic effect, and the synergistic acaricidal composition has excellent effects of controlling various mite pests on fruit trees, vegetables, cotton, tea trees and other crops, flowers and plants; the control effect is improved; and moreover, the amount of pesticides is reduced, so that the cost is reduced, the environmental pollution is reduced, the resistance management of the mite pests is promoted, and the composition has great economic benefits and social benefits in popularization and application.
Description
Technical field
The present invention relates to agricultural chemicals miticide composition and application thereof, specifically a kind of with tebufenpyrad and Ivermectin HCL for active ingredient Synergistic mite killing composition, be applied to the control of evil mite on fruit tree, cotton and vegetables.
Background technology
Tebufenpyrad, english common name: tebufenpyrad, be a kind of obligate miticide, belong to Mitochondria In Developing Flight Muscle of Insects respiration inhibitor, its mechanism of action suppresses electron transmission at I place, site, instead of the biogenic amine acted in insect bodies or acetylcholinergic receptor, neither as special muscle or never poison, its physiology drug effect is rapid, to two spotted spider mite ovum, becomes mite effect all better, lasting period can reach more than 40 days, has certain resistance of rainwater washing against ability.
Ivermectin HCL, english common name: ivermectin, the mechanism of action of Ivermectin HCL is mainly combined with the high-affinity being the chloride channel of valve without spinal animals nerve cell and muscle cell Glutamic Acid, thus cause cell membrane to the increase of chlorion permeability, cause nerve cell or muscle cell hyperpolarization, insect is benumbed or death, agriculturally can be used for the pest such as control vegetables diamond-back moth, fruit tree mites.
Mite class is the common insect of a class, and the crops such as danger to vegetables, fruit tree and cotton, often cause destructive disaster to crop.Evil mite occurs from generation to generation many, and fertility is strong, and under suitable temperature and humidity conditions, evil mite quantity increases rapidly in the short period of time exponentially, thus easily develops immunity to drugs to miticide, causes serious harm to crop simultaneously.
Different pesticide species composition carries out composite, is the common methods of control agriculture resistant insect evil mite.The present inventor is on the basis of a large amount of indoor virulences and field medicine effect test, the compounded formula screening of tebufenpyrad and Ivermectin HCL is conducted in-depth research, find that tebufenpyrad and Ivermectin HCL carry out composite, in certain proportion, there is obvious synergistic function, and to various harmful mite, there is outstanding control efficiency, after further study, the present invention is completed.
Summary of the invention
The object of the present invention is to provide a kind of Synergistic mite killing composition containing tebufenpyrad and Ivermectin HCL, be applied to the control of evil mite on fruit tree, cotton and vegetables.
Another object of the present invention is to the miticide composition containing tebufenpyrad and Ivermectin HCL, in use can reduce dosage, reduce the residual quantity of agricultural chemicals on crops, delay the drug-fast generation of mite pest, it can also be made to be used alone to compare than single dose to the control efficiency of various mite pest and to significantly improve, laborsaving, economical, reduce farmer's burdens.
Technical scheme of the present invention: a kind of Synergistic mite killing composition, active ingredient is made up of tebufenpyrad and Ivermectin HCL, the ratio of weight and number of tebufenpyrad and Ivermectin HCL is 20:1 ~ 1:20, tebufenpyrad and the percentage by weight of Ivermectin HCL weight summation in miticide composition are 5%-80%, and all the other are allow in agricultural chemicals to use and acceptable auxiliary element.
Composition pesticide of the present invention can adopt known method to be prepared into applicable any one formulation agriculturally used, and reasonable formulation is suspending agent, aqueous emulsion, microemulsion, water dispersible granules, wetting powder.
The auxiliary agent used in the present composition comprise solvent, dispersant, stabilizing agent, emulsifier, antifreezing agent, thickener etc. and other to be of value to active ingredient stable and play the known substance of drug effect in the formulation, all various compositions that are conventional in pesticidal preparations or permission use, be not particularly limited, concrete composition and consumption are determined by simple test according to recipe requirements.
Product described in the invention can the form of finished product preparation provide, and namely in composition, each material mixes, and the composition of composition also can the form of single dose provide, and directly mixes in tank or bucket, be then diluted to required concentration before using.
Miticide composition of the present invention is applicable to various mite pest on the crops such as control fruit tree, vegetables, cotton.
The frequency of administration of miticide composition of the present invention and amount of application change with weather condition and crop condition change, can by the object using suitable formulation to reach control
Compared with prior art, the invention has the advantages that:
1, tebufenpyrad and Ivermectin HCL is composite has obvious synergistic function, is used alone the control efficiency that improve evil mite than single dose;
2, tebufenpyrad and the Ivermectin HCL mechanism of action different, evil mite drug-fast generation can be delayed;
3, tebufenpyrad and Ivermectin HCL two kinds of active ingredients composite, decrease Pesticide use amount, reduce use cost and alleviate pollution to environment.
Embodiment
In order to understand essence of the present invention better; below in conjunction with embodiment, content of the present invention is described further; but can not limitation of the present invention be considered as; the following stated is only for explaining the present invention; for not departing from amendment that the present invention's spirit and principle make, replacement or improvement, all belong to the scope of protection of present invention.
In the embodiment of the present invention, active ingredient adopts the former medicine of 93% tebufenpyrad, the former medicine of 95% Ivermectin HCL, and each component percentages described in embodiment is weight percentage.
Example of formulations 1:21% tebufenpyrad Ivermectin HCL suspending agent.
Tebufenpyrad 20%, Ivermectin HCL 1%, alkyl naphthalene formaldehyde condensation product sodium sulfonate 10%, Nekal BX 10%, CMC 1%, glycerine 2%, silicone oil 0.1%, deionized water supplies 100%.Above-mentioned active ingredient, dispersant, wetting agent, thickener, antifreezing agent, defoamer and deionized water are mixed, sand milling in high speed shear dispersion, sand mill, the high dispersive formed in water-medium, stable suspension system, can obtain 21% tebufenpyrad Ivermectin HCL suspending agent.
Example of formulations 2:11% tebufenpyrad spiral shell mite dibasic acid esters aqueous emulsion.
Tebufenpyrad 10%, Ivermectin HCL 1%, cocoa butter heptyl ester 20%, polyoxyethylene nonylphenol ether 15%, alkylnaphthalene sulfonate 5%, sodium sorbate 1%, glycerine 1%, deionized water supplies 100%.Above-mentioned active ingredient, solvent, emulsifier, dispersant and stabilizing agent are mixed to form oil phase, antifreezing agent dissolves and forms aqueous phase in water, slowly oil phase is added in aqueous phase under clipper effect, and continue to shear about 30 minutes, 11% tebufenpyrad Ivermectin HCL aqueous emulsion can be obtained.
Example of formulations 3:25% tebufenpyrad Ivermectin HCL microemulsion.
Tebufenpyrad 23%, Ivermectin HCL 2%, cyclohexanone 10%, DMF 10%, styrylphenol polyoxyethylene ether 15%, xylitol 1.5%, organosilicon 1.5%, thiophene ketone 2%, deionized water supplies 100%.Active ingredient solvent is dissolved completely, and then add emulsifier, stabilizing agent, bleeding agent, synergist mix, finally add deionized water, after fully stirring, 25% tebufenpyrad Ivermectin HCL microemulsion can be obtained.
Example of formulations 4:30% tebufenpyrad Ivermectin HCL wetting powder.
Tebufenpyrad 28%, Ivermectin HCL 2%, alkyl naphthalene formaldehyde condensation product sodium sulfonate 5%, calcium dodecyl benzene sulfonate 10%, diatomite supplies 100%.By above-mentioned, active ingredient, dispersant, wetting agent and filler are mixed, again through air-flow crushing after mechanical crushing, mix, 30% tebufenpyrad Ivermectin HCL wetting powder can be obtained.
Example of formulations 5:29% tebufenpyrad Ivermectin HCL water dispersible granules.
Tebufenpyrad 26%, Ivermectin HCL 3%, alkylphenol polyoxyethylene 10%, neopelex 10%, sodium carbonate 3%, polyvinyl alcohol 2%, kaolin supplies 100%.Above-mentioned active ingredient, dispersant, wetting agent, disintegrant, binding agent and filler are mixed, pulverize with micro jet, through mediating, then adding in fluidized-bed granulation dryer and carrying out granulation, drying, screening, 29% tebufenpyrad Ivermectin HCL water dispersible granules can be obtained.
Assays Example 1: tebufenpyrad and Ivermectin HCL are to the indoor joint toxicity measuring of panonychus citri
Test medicine adopts the former medicine of 93% tebufenpyrad and the former medicine of 95% Ivermectin HCL.
If examination worm is from the panonychus citri mite of citrus orchard collection through indoor feeding 3 generation.
Test method employing leaf butterfly spray-on process (with reference to " NY/T 1154.13-2008 farm-chemical indoor determination test rule insecticide. the 13rd part: leaf butterfly spray-on process ").Concrete operation method is as follows:
Each single dose and Mixed Pharmacy are arranged 5 different concentration gradients (on the basis of preliminary experiment result, if panonychus citri mite lethality in the scope of 5%-90% by geometric progression setting).
Choose the Citrus leaf that growth is consistent, make leaf butterfly with card punch, in culture dish, place a wet sponge block, it puts filter paper, foliation butterfly on filter paper, every ware puts 2 pieces of leaf butterflies, if selecting healthy, that Individual Size is consistent panonychus citri mite is inoculated on leaf butterfly, every leaf butterfly inoculates 20.
Under the culture dish being connected to leaf butterfly is placed in potter spray tower, spray under 50PSI pressure, spray amount is 1ml, culture dish is taken out after sedimentation 1min, then the culture dish processed is put into 12H/12H illumination box to cultivate, 48h checks dead mite number, calculates lethality.Often 4 repetitions are established in process, and establish the process of clear water blank.
Statistical analysis is carried out, by calculating the LC of each medicament with DPS statistical analysis software
50evaluate the acaricidal activity of each medicament, and calculate the co-toxicity coefficient (CTC value) of mixture according to the abundant method of Sun Yun.
Actual measurement toxicity index (ATI)=(standard agent LC
50/ reagent agent LC
50) × 100.
In theoretical toxicity index (TTI)=A medicament toxicity index × mixture A percentage composition+B medicament toxicity index × mixture in the percentage composition of B.
Co-toxicity coefficient (CTC)=[the theoretical toxicity index (TTI) of mixture actual measurement toxicity index (ATI)/mixture] × 100.
According to the NY/T11547.7-2006 insecticide combination effect criteria for classifying: co-toxicity coefficient (CTC) >=120 shows as synergistic effect; Co-toxicity coefficient (CTC)≤80 shows as antagonism; 80 < co-toxicity coefficient (CTC) < 120 show as summation action.
As can be seen from Table 1, when tebufenpyrad and Ivermectin HCL are composite in the scope of 20:1 ~ 1:20 (by weight), co-toxicity coefficient (CTC) is all greater than 120, if show obvious synergistic function to panonychus citri mite.Visible tebufenpyrad and Ivermectin HCL is composite has reasonability and feasibility.
If table 1, tebufenpyrad and Ivermectin HCL are to the indoor joint toxicity measuring result of panonychus citri mite
Assays Example 2: tebufenpyrad and the composite field control effectiveness test to panonychus citri of Ivermectin HCL.
Adopt 21% tebufenpyrad Ivermectin HCL suspending agent (example of formulations 1) for preventing and treating panonychus citri, investigation insect population radix before dispenser, after medicine, 3d, 7d, 14d, 30d investigate residual mite number of living respectively, 2 strains are looked in investigation Shi Mei community, every strain looks into 5 blades respectively by orientation, 4, the four corners of the world, every community looks into 40 blades altogether, records mite number of living, and calculates control efficiency.Control efficiency computational methods are as follows:
Control efficiency (%)=(1-CK
1× Pt
1/ CK
2× Pt
2) × 100.
Wherein: CK
1represent insect population number before the medicine of check plot; Pt
1represent insect population number after treatment region medicine;
CK
2represent insect population number after the medicine of check plot; Pt
2represent insect population number before treatment region medicine;
The result of the test of table 2,21% tebufenpyrad Ivermectin HCL suspending agent control panonychus citri
21% tebufenpyrad Ivermectin HCL suspending agent uses after 1000 ~ 2000 times of 3d, 7d, 14d, 30d and all 1000 times and 0.5% Ivermectin HCL missible oil single dose will be used to use 500 times apparently higher than the tebufenpyrad suspending agent single dose same period 20% to the preventive effect of panonychus citri as can be seen from Table 2, can improve panonychus citri preventive effect compared with illustrating that tebufenpyrad and Ivermectin HCL are composite and being used alone with two kinds of single doses, after medicine, 30d preventive effect still reaches more than 80% simultaneously, illustrate to have good lasting effect, duration of test does not find that this compound drug produces poisoning to oranges and tangerines.
Assays Example 3: tebufenpyrad and the composite field control effectiveness test to cotton Tetranychus cinnabarinus of Ivermectin HCL.
Adopt 25% tebufenpyrad Ivermectin HCL microemulsion (example of formulations 3) for preventing and treating cotton Tetranychus cinnabarinus, investigation insect population radix before dispenser, after medicine, 3d, 7d, 14d, 30d investigate residual mite number of living respectively, 2 strains are looked in investigation Shi Mei community, every strain looks into 5 blades respectively by orientation, 4, the four corners of the world
Each community looks into 40 blades altogether, records mite number of living, and calculates control efficiency.Control efficiency computational methods are as follows:
Control efficiency (%)=(1-CK
1× Pt
1/ CK
2× Pt
2) × 100.
Wherein: CK
1represent insect population number before the medicine of check plot; Pt
1represent insect population number after treatment region medicine;
CK
2represent insect population number after the medicine of check plot; Pt
2represent insect population number before treatment region medicine;
Table 3,25% tebufenpyrad Ivermectin HCL microemulsion control cotton Tetranychus cinnabarinus result of the test
25% tebufenpyrad Ivermectin HCL microemulsion uses after 1000 ~ 2000 times of 3d, 7d, 14d, 30d and all 1000 times and 0.5% Ivermectin HCL missible oil single dose will be used to use 500 times apparently higher than the tebufenpyrad suspending agent single dose same period 20% to the preventive effect of cotton Tetranychus cinnabarinus as can be seen from Table 3, can improve cotton Tetranychus cinnabarinus preventive effect compared with illustrating that tebufenpyrad and Ivermectin HCL are composite and being used alone with two kinds of single doses, after medicine, 30d preventive effect still reaches more than 80% simultaneously, illustrate to have good lasting effect, duration of test does not find that this compound drug produces poisoning to cotton.
In sum, the present invention adopts two kinds of active components to be the compound acaricide composition of tebufenpyrad and Ivermectin HCL, compared with existing unitary agent, not only there is obvious synergistic effect, also have good miticidal effect, the lasting period is long, to Crop securify, the drug-fast generation of harmful mite can be slowed down, be worth applying in agricultural production.
Claims (3)
1. one kind contains the Synergistic mite killing composition of tebufenpyrad and Ivermectin HCL, it is characterized in that: active ingredient is made up of tebufenpyrad and Ivermectin HCL, the ratio of weight and number of tebufenpyrad and Ivermectin HCL is 20:1 ~ 1:20, and tebufenpyrad and the percentage by weight of Ivermectin HCL weight summation in miticide composition are 5%-80%.
2. a kind of Synergistic mite killing composition containing tebufenpyrad and Ivermectin HCL according to claim 1, is characterized in that: make the formulation suspending agent, aqueous emulsion, microemulsion, water dispersible granules or the wetting powder that are applicable to agriculturally using during practical application.
3. a kind of Synergistic mite killing composition containing tebufenpyrad and Ivermectin HCL according to claim 1 and 2 is used for agriculturally preventing and treating the application in various harmful mite.
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| CN201410822856.7A CN104521999B (en) | 2014-12-25 | 2014-12-25 | A kind of Synergistic mite killing composition containing tebufenpyrad and Ivermectin HCL |
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| CN104521999A true CN104521999A (en) | 2015-04-22 |
| CN104521999B CN104521999B (en) | 2018-02-16 |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1947508A (en) * | 2006-11-05 | 2007-04-18 | 深圳诺普信农化股份有限公司 | Miticide contg. abamectin and tebrfenpyrad synergistic building effect |
| CN101203135A (en) * | 2005-04-28 | 2008-06-18 | 拜尔农作物科学股份公司 | Combinations of pesticidal active substance combinations |
| CN101606517A (en) * | 2009-07-27 | 2009-12-23 | 深圳诺普信农化股份有限公司 | A kind of farm chemical emulsion preparation |
| WO2010046463A1 (en) * | 2008-10-23 | 2010-04-29 | Basf Se | Use of selected insecticides on cultivated plants |
| CN101933518A (en) * | 2003-11-14 | 2011-01-05 | 拜尔农作物科学股份公司 | Active agent combinations with insecticidal and acaricidal properties |
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2014
- 2014-12-25 CN CN201410822856.7A patent/CN104521999B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101933518A (en) * | 2003-11-14 | 2011-01-05 | 拜尔农作物科学股份公司 | Active agent combinations with insecticidal and acaricidal properties |
| CN101203135A (en) * | 2005-04-28 | 2008-06-18 | 拜尔农作物科学股份公司 | Combinations of pesticidal active substance combinations |
| CN1947508A (en) * | 2006-11-05 | 2007-04-18 | 深圳诺普信农化股份有限公司 | Miticide contg. abamectin and tebrfenpyrad synergistic building effect |
| WO2010046463A1 (en) * | 2008-10-23 | 2010-04-29 | Basf Se | Use of selected insecticides on cultivated plants |
| CN101606517A (en) * | 2009-07-27 | 2009-12-23 | 深圳诺普信农化股份有限公司 | A kind of farm chemical emulsion preparation |
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