CN104510668B - Moisture-keeping composition and its preparation method and application - Google Patents
Moisture-keeping composition and its preparation method and application Download PDFInfo
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Abstract
The present invention relates to a kind of moisture-keeping composition and its preparation method and application, moisture-keeping composition includes moisturizing active component, and the moisturizing active component at least includes prinsepia utilis royle oil and blue or green bur polysaccharide, and the weight ratio of prinsepia utilis royle oil and blue or green bur polysaccharide is 0.5 ~ 10:1.The present invention compounds prinsepia utilis royle oil and blue or green bur polysaccharide in specific proportions, with synergistic function, when other conditions are identical, all has more preferable moistening effect using any of which using combination ratio.Moisture-keeping composition of the present invention has good effect in terms of moisturizing, suitable for being applied in cosmetics, health products and medicine, especially can be applied in cosmetics, and different consumptions are added according to the different type of preparation.
Description
Technical field
The present invention relates to moisture-keeping composition and preparation method thereof.
Background technology
The barrier function of skin sparing interior tissue depends on the hydration moisture-retaining capacity of skin, and the moisture storage capacity of skin accounts for whole body
18%-20%.Temperature change and pressure that air-conditioning, environmental pollution, Seasonal conversion are brought, and skin senescence, metabolism slow down
It can all cause skin excessive water to be lost in etc. factor, make coarse skin, dim mute, the dry line of formation, trigger many skin problems.Prevent
Moisture of skin is excessively lost in, and is for the health of the good skin barrier function of holding and skin, or even the outward appearance of skin beauty
It is very important.
In order to reach holding moisture of skin, the lost purpose of excessive water is reduced, adds and protects generally in skin preparations for extenal use
Wet composition.NMF species is a lot, and conventional moisturizing ingredient can be divided into enclosed type NMF and the major class of hygroscopicity NMF two.
The effect of enclosed type NMF is by skin surface formation film layer, stopping moisture of skin evaporation, so that cuticula keeps one
Fixed water content, this class NMF includes mineral oil and wax such as vaseline, vegetable oil and animal tallow such as lanolin, phosphatide,
Cholesterol etc..Hygroscopicity NMF be a class be similar to epidermis in NMF, can with water strength combine and reaching makes
The effect of cuticula moisturizing.Such moisturizing ingredient has：NMF, protein, polysaccharide, ceramide, various vitamins
Deng.The problems such as NMF of animal and mineral origin easily causes allergic, skin irritatin, natural moisture preserving is found from plant
Agent meets people to coming from the demands of natural cosmetics.
Green grass or young crops is pierced as rose family Prinsepia Royle plant Prinsepia utilis Prinsepia utilis, also known as buy oil fruit, passion fruit etc..It is blue or green
Thorn production Yunnan, Guizhou, Sichuan, Tibet.It is born in hillside, wasteland, mountain valley or roadside etc., 1000-2560 meters of height above sea level.Buckie this
Smooth, Nepal, Bhutan and north India are also distributed.Green grass or young crops thorn stem, leaf, fruit, root can be used as medicine, and taste micro-pungent has promoting blood circulation, disappeared
The effects such as swollen analgesic, treatment bullet wound.Green grass or young crops thorn seed is rich in grease, general oil yield 30% or so.
Traditionally, application of the blue or green bur in existing more than one thousand years among the people.Prinsepia utilis royle oil is applied on skin, can prevent mosquito
The lump of bruises and sprains formation is bitten or eliminated, chapped skin, itch is prevented and cures pernio；It can be pressed down with prinsepia utilis royle oil rubbing head hair
Epilation processed, plays the role of to make white hair blackening；Human body skin localized burn and scald, affected part is applied to prinsepia utilis royle oil to prevent
Wound infection, accelerates wound healing and preventing from scar.It is among the people in locality, the skin of ewborn infant is smeared with prinsepia utilis royle oil, makes skin
The dry and comfortable lubrication of skin, and coming off for baby lanugo can be promoted.According to patent retrieval, application of the green grass or young crops bur in terms of cosmetics at present is equal
Using prinsepia utilis royle oil as research object.In modern products application, prinsepia utilis royle oil is also mostly applied, and develop its moisturizing,
Crease-resistant the effects such as.
The content of the invention
The technical problems to be solved by the invention are to provide a kind of with synergistic function, the excellent moisturizing of moistening effect
Composition.
Present invention simultaneously relates to the application of above-mentioned composition and preparation method.
To solve above technical problem, a kind of technical scheme that the present invention takes is：
A kind of moisture-keeping composition, including moisturizing active component, particularly, the moisturizing active component at least include prinsepia utilis royle oil
Weight ratio with blue or green bur polysaccharide, and prinsepia utilis royle oil and blue or green bur polysaccharide is 0.5~10:1.
Preferably, the weight ratio of prinsepia utilis royle oil and blue or green bur polysaccharide is 0.5~6:1.It is highly preferred that prinsepia utilis royle oil is pierced with blue or green
The weight ratio of fruit polysaccharide is 2~6:1, most preferably, the weight ratio of prinsepia utilis royle oil and blue or green bur polysaccharide is 1~3:1.
The moisture-keeping composition of the present invention has good effect in terms of moisturizing, suitable in cosmetics, health products and medicine
Using especially can be applied in cosmetics, different consumptions added according to the different type of preparation.
The present invention relates particularly to a kind of external skin moisturizer, and it contains the above-mentioned moisture-keeping composition of the present invention.
General, the mass content that the moisturizing active component accounts for the external skin moisturizer is 1~20%.It is preferred that
Ground, the mass content that moisturizing active component accounts for external skin moisturizer is 5~15%.
According to the present invention, bur oil, blue or green bur polysaccharide can be prepared using conventional means known in this field, can also
It is commercially available.
The another technical scheme that the present invention takes is：A kind of preparation method of above-mentioned moisture-keeping composition, it includes following
Step：
(1) using blue or green bur seed as raw material, prinsepia utilis royle oil and oil meal are obtained through solvent impregnated extraction, by what is remained in oil meal
Solvent is removed, stand-by；
(2) oil meal obtained by step (1) is boiled in boiling water, bits is filtered off after boiling, retained filtrate, three are added after filtrate concentration
Monoxone, takes off albumen at 0~10 DEG C, and centrifugation, supernatant adds alkali to neutralize, flowing water dialysis, concentration, and adding ethanol makes system second
Alcohol mass content is 75%~85%, and precipitation is freeze-dried to obtain bur polysaccharide.
According to a specific and preferred aspect, in step (1), the solvent is petroleum ether, and step (1) is embodied such as
Under：Blue or green bur seed is taken, is dried, is crushed, is extracted three times, soaked 6~8 days every time with petroleum ether soaking at room temperature, after the completion of immersion,
Petroleum ether extract is concentrated in vacuo, and is reclaimed petroleum ether, is obtained prinsepia utilis royle oil, and the oil meal after being extracted through petroleum ether, volatilization is complete
The petroleum ether of residual is removed, it is stand-by.
According to another specific and preferred aspect, in step (2), the de- albumen is set to be carried out at 0~5 DEG C, the dialysis
Time is 30~60 hours, and the ethanol of the addition is the ethanol of volumn concentration 95%.
According to the present invention, in moisture-keeping composition moisturizing active component can also include other one or more of activity into
Point.Other active components can be such as panthenol, dipotassium glycyrrhizinate, allantoin, niacinamide, NAP, three colors
Violet extract, Sodium Hyaluronate, tocopherol acetate, undecylenoyl phenylalanine etc..In addition, such description is in order to just
It is not composition is limited to the application or listed application specifically noted in understanding.
According to the present invention, the skin preparations for extenal use is typically used for the general designation concept of all the components outside skin, for example
Can be cosmetic combination or pharmaceutical compositions.Can be foundation make up material, facial dressing in the cosmetic combination
Makeup material, body cosmetic preparation, hair nursing cosmetic preparation etc., to its formulation without specifically limited, can rationally be selected according to different purposes
Select.
Bu Tong also allowing containing different cosmeceutical aspects according to formulation and purpose in the cosmetic combination
Medium or matrix excipients.
Can be used for cosmetics, dermatology or the pharmaceutically acceptable excipient of skin preparations for extenal use of the present invention can be
Aqueous phase, oil phase, gel, water bag wax pattern emulsion, the form of emulsion oil-in-water or water-in-oil emulsion.Aqueous phase is one or more
The mixture of water-soluble or dispersed component, it can be at room temperature liquid, semi-solid or solid.Excipient includes or can be with
For the form of the suspension in water or water-alcohol excipient, dispersion liquid or solution, it can contain thickener or gel.This
The suitable product form of knowledge-chosen and the group wherein included that art personnel can be grasped based on those skilled in the art
Point.
The cosmetic combination can include aqueous phase, and the aqueous phase can be organic containing water or water and at least one hydrophily
The mixture of solvent, described hydrophilic organic solvent such as alcohol, the straight or branched especially containing 2-5 carbon atom is rudimentary
Monohydric alcohol, such as ethanol or propyl alcohol；Polyalcohol, such as propane diols, sorbierite, glycerine, panthenol or polyethylene glycol and its mixture.
When cosmetic combination is emulsion form, said composition can also optionally include surfactant.
The cosmetic combination can also include film forming polymer, such as polyurethanes, polyacrylic acid homopolymer or
Copolymer, polyester, resin and/or silicone resin based on hydrocarbon.It can dissolve a polymer in or be scattered in cosmetics and be subjected to
Excipient in and optionally merge with plasticizer.
Cosmetic combination of the present invention can also include oil phase, and described oil phase contains oil-soluble at room temperature for liquid
Or oil-dispersing property component and/or at room temperature be oily or wax-like material, such as wax, semisolid, natural gum and its mixture.The oil
Organic solvent mutually can also be contained.
Generally it is liquid at room temperature, suitable oily matter includes：From the oil based on hydrocarbon of animal, such as perhydrogenating
Squalene；The triglyceride of the C4-10 aliphatic acid of vegetable oil based on hydrocarbon, such as liquid, such as enanthic acid or Trivent OCG
Class, or oil, such as sunflower oil, corn oil, soybean oil, grape-kernel oil, castor oil, avocado oil, caprylic/capric triglyceride
Class, jojoba oil；The straight or branched hydro carbons of mineral or synthesis source, such as liquid paraffin and its derivant, vaseline；Synthesis
The esters of esters and ethers, particularly fatty alcohol, such as isopropyl myristate, palmitic acid 2- ethylhexyls, stearic acid 2- are pungent
Base dodecyl ester, isostearyl isostearate ester；Hydroxylating esters, such as lactic acid isooctadecanol ester, octyl hydroxystearate,
Octyl hydroxystearate, hydroxy stearic acid octyldodecyl, the enanthic acid esters of fatty alcohol, sad esters and capric acid lipid；
Polyalcohol esters, such as propylene, the heptanoate of neopentyl glycol two, the isononoate of diethylene glycol (DEG) two and pentaerythritol ester
Class；Aliphatic alcohols containing C 12-26, such as octyldodecanol, 2- butyl octanol, 2- hexyl decyl alcohols, 2- undecyls ten
Five alkanols, oleyl alcohol；Fluorocarbon oil and/or fluorosilicon oil based on part hydrocarbon, silicone oil, at room temperature for liquid or semisolid volatility or
Non-volatile straight chain or cyclo-methicone, such as X 2-1401 and dimethyl silicone polymer, its
Choosing includes phenyl, such as Silicone DC 556, siloxanes and its mixture.
Cosmetic combination of the present invention can be further comprising any component being usually used in cosmetic field.These components
Including preservative, water phase thickener (polysaccharide biopolymer, synthetic polymer) and fatty phase thickener, aromatic, hydrophily
With lipophilic active agent and its mixture.
The composition of the present invention can be configured to any suitable product form.This kind of product form includes, but does not limit
In aerosol spray, creme, emulsion, solid, liquid, dispersion, foam, gel, toner, mousse, ointment, pulvis,
Patch, brilliantine, solution, hand press pump-type spray, club, facial mask and hygenic towelette.The composition of the present invention can be passed through
Various methods well-known in the art are advantageously available for preparing or produced as cosmetics, dermatology or medicine local application
Product.
The skin preparations for extenal use of the present invention can include one or more following ingredients：Anti-allergic agent, antimicrobial, antioxygen
Agent, chelating agent, colouring agent depigmentation, emollient, emulsifying agent, excoriation agent, film forming agent, spices, NMF, insect drive
Keep away agent, lubricant, pharmaceutically active agents, humidizer, photostabilizer, preservative, skin conditioner, skin penetration enhancer, sun-screening agent, stably
Agent, surfactant, thickener, viscosity modifier, vitamin or its any combination.
Due to the use of above technical scheme, the present invention has following advantage compared with prior art：
The present invention compounds prinsepia utilis royle oil and blue or green bur polysaccharide in specific proportions, with synergistic function, at other
When part is identical, all there is more preferable moistening effect using any of which using combination ratio.
Embodiment
Below to be described in further details in conjunction with specific embodiments to the present invention.It should be understood that these embodiments are used to say
The bright basic principles, principal features and advantages of the present invention, and the present invention is not limited by the following examples.Used in embodiment
Implementation condition can do further adjustment according to specific requirement, and unreceipted implementation condition is usually the condition in normal experiment.
Raw materials used embodiment is industrial goods.
Embodiment 1：The extraction of prinsepia utilis royle oil
The extraction of prinsepia utilis royle oil reduces unsaturated fat in prinsepia utilis royle oil as far as possible by the way of low-temperature extraction in the present invention
The loss of acid.Blue or green bur seed is taken, is dried, is crushed.Extracted three times with petroleum ether soaking at room temperature, every time immersion 7 days.Immersion is completed
Afterwards, petroleum ether extract is concentrated in vacuo, and is reclaimed petroleum ether, is obtained prinsepia utilis royle oil.Oil meal after being extracted through petroleum ether, is evaporated completely
The full petroleum ether for removing residual, the extraction as the blue or green bur polysaccharide of next step.
Embodiment 2：It is prepared by blue or green bur polysaccharide
The prinsepia utilis royle oil dregs of rice about 30g is taken, 300ml boiling water boilings are added 3 times, each filtrate is merged, about 300ml is concentrated into, plus
Trichloroacetic acid takes off albumen at 4 DEG C；Centrifugation, supernatant NaOH is neutralized, flowing water dialysis 2d；About 150ml is concentrated into, 95% second is added
Alcohol makes system alcohol content up to 75%；Pellet frozen it is dry blue or green bur polysaccharide -1.
Embodiment 3：It is prepared by blue or green bur polysaccharide
Residue about 30g after blue or green bur alcohol extracting is taken, 300ml boiling water boilings are added 3 times, each filtrate is merged, is concentrated into about
300ml, plus trichloroacetic acid take off albumen at 4 DEG C；Centrifugation, supernatant NaOH is neutralized, flowing water dialysis 2d；About 150ml is concentrated into, plus
Entering 95% ethanol makes system alcohol content up to 80%；Pellet frozen it is dry blue or green bur polysaccharide -2.
Embodiment 4：It is prepared by blue or green bur polysaccharide
The prinsepia utilis royle oil dregs of rice about 30g is taken, 300ml boiling water boilings are added 3 times, each filtrate is merged, about 300ml is concentrated into, plus
Trichloroacetic acid takes off albumen at 4 DEG C；Centrifugation, supernatant NaOH is neutralized, flowing water dialysis 2d；About 150ml is concentrated into, 95% second is added
Alcohol makes system alcohol content up to 85%；Pellet frozen it is dry blue or green bur polysaccharide -3.
Embodiment 5：Sugared content is determined
Using sulfuric acid-phynol method, with trap at spectrophotometric determination 490nm after colour developing, using glucose as control, paint
Standard curve processed, calculates sugared content in blue or green bur polysaccharide.
1. standard curve, is made：Dextran standards (or glucose) 20mg accurately is weighed in 500ml volumetric flasks, is added water
To scale, 0.4,0.6,0.8,1.0,1.2,1.4,1.6 and 1.8ml is drawn respectively, is respectively mended with distilled water to 2.0ml, Ran Houjia
Enter 6% phenol 1.0ml and concentrated sulfuric acid 5.0ml, shake up cooling, room temperature places 20 minutes with after 490nm densitometrics, with
2.0ml water is blank by same color operation, and abscissa is polysaccharide micrograms, and ordinate is OD value, obtains standard curve.
2. 1 gram of sample plus the grinding of 1ml 15%TCA solution, are taken, then adds a little 5%TCA solution grinding, supernatant is in 10
In milliliter centrifuge tube, then add a little 5%TCA solution grinding, supernatant, is repeated 3 times.Last time by residue one play into from
Heart pipe.Note：Total solution does not get higher than 10 milliliters.
3., centrifuge, 3000 revs/min of rotating speed, totally three times.15 minutes for the first time, take supernatant.Take within each 5 minutes twice afterwards
Supernatant is into 25 milliliters of taper colorimetric cylinders.Last filtrate is kept for 18 milliliters or so.
4., water-bath, shakes up, water-bath 2 is small in 96 DEG C of water-baths after 2 milliliters of 6mol/L hydrochloric acid are added into colorimetric cylinder
When.
5., constant volume samapling.2 milliliters of 6mol/L sodium hydroxides are added after water-bath, after being cooled down with flowing water to shake up.It is settled to 25 millis
In the volumetric flask risen.0.2ml sample liquid is drawn, is mended with distilling to 2.0ml, then adds 6% phenol 1.0ml and the concentrated sulfuric acid
5.0ml, shakes up cooling room temperature and places 20 minutes with after 490nm densitometrics.Determine every time and take double sample controls.With standard curve
Calculate polyoses content.
6., result：Regression equation is computed for Y=7.4898X-0.00442, R2=0.9996, glucan concentration 0~
With absorbance in well linear in the range of 105.0 μ g/mL.Sample absorbance is measured in the same method, calculating obtains blue or green bur polysaccharide -1
Middle total sugar content is 33.85%, and total sugar content is that total sugar content is in 40.38%, blue or green bur polysaccharide -3 in blue or green bur polysaccharide -2
38.67%.
Embodiment 6：Emollient cream containing prinsepia utilis royle oil and blue or green bur polysaccharide
Conventionally, it is formulated according to table 1 and prepares moistening for the prinsepia utilis royle oil comprising different proportion and blue or green bur polysaccharide
Frost：
Table 1
Embodiment 7：The moisture-keeping functions evaluation of the emollient cream of embodiment 6
When every kind of composition is applied one time, in order to test the long moisturizing performance of composition, by severalization in embodiment 6
Cosmetic compositions are applied to the complaint dry skin of 30 30-40 Sui or firmly believe the face of the men and women with Dry
And inner forearm.After 24 hours, using moisture of skin tester (CM820ourage Khazaka electronic GmbH,
Germany) determine the skin moisture content of each subject.Before applying and starting, using moisture of skin tester in steady temperature and
The skin moisture content of each subject is determined under conditions of constant humidity (24 DEG C and 40% humidity), and as reference value, is surveyed
It is fixed apply after at once and after applying the skin moisture content of 2 hours, 4 hours and 8 hours change.Measurement result is shown in down
In table 2.
Use the assay method of moisture of skin tester
Principle：Determine the water ion degree in epiderm skin to determine performance of keeping humidity by using sensor, represented with numerical value
Measurement result, and calculate moisture.
1) probe of moisture of skin tester is placed in skin part to be measured.
2) when probe extrudes skin, the electric capacity of skin will be included on screen with numerical value by sensor.
3) after once determining, sensor is wiped using dust-free paper, the measure at another position is then carried out.
Table 2
According to test result, the emollient cream containing different proportion prinsepia utilis royle oil and blue or green bur polysaccharide all has good skin
Moistening effect.Meanwhile, in the case of total amount of adding identical, the sample containing prinsepia utilis royle oil and blue or green bur polysaccharide has more preferable
Moistening effect, especially permanent moistening effect is more notable, such as formula 3, formula containing prinsepia utilis royle oil and blue or green bur polysaccharide
4th, formula 5 has than 1 (containing only blue or green bur polysaccharide) of formula and the more longlasting moistening effect of 2 (containing only prinsepia utilis royle oils) of formula.It is former
Cause is probably that the formula containing blue or green bur composite extract all has contribution at two aspects of enclosed type moisturizing and hygroscopicity moisturizing.
The present invention is described in detail above, its object is to allow the personage for being familiar with this art to understand this
The content of invention is simultaneously carried out, and it is not intended to limit the scope of the present invention, all Spirit Essence institutes according to the present invention
The equivalent change or modification of work, should all cover within the scope of the present invention.
Claims (9)
1. a kind of moisture-keeping composition, including moisturizing active component, it is characterised in that：The moisturizing active component at least includes blue or green thorn
Fruit oil and blue or green bur polysaccharide, and the weight ratio of the prinsepia utilis royle oil and blue or green bur polysaccharide is 0.5~10:1.
2. moisture-keeping composition according to claim 1, it is characterised in that：The weight of the prinsepia utilis royle oil and blue or green bur polysaccharide
Than for 0.5~6:1.
3. moisture-keeping composition according to claim 2, it is characterised in that：The weight of the prinsepia utilis royle oil and blue or green bur polysaccharide
Than for 1~3:1.
4. a kind of external skin moisturizer, it is characterised in that：Contain the moisture-keeping composition described in claim 1 or 2 or 3.
5. external skin moisturizer according to claim 4, it is characterised in that：The moisturizing active component accounts for described outer
It is 1~20% with the mass content of skin moisture-keeping product.
6. external skin moisturizer according to claim 5, it is characterised in that：The moisturizing active component accounts for described outer
It is 5~15% with the mass content of skin moisture-keeping product.
7. the preparation method of the moisture-keeping composition described in a kind of claim 1 or 2 or 3, it is characterised in that comprise the following steps：
(1) using blue or green bur seed as raw material, prinsepia utilis royle oil and oil meal are obtained through solvent impregnated extraction, it is molten by what is remained in oil meal
Agent is removed, stand-by；
(2) oil meal obtained by step (1) is boiled in boiling water, bits is filtered off after boiling, retained filtrate, trichlorine is added after filtrate concentration
Acetic acid, takes off albumen at 0~10 DEG C, and centrifugation, supernatant adds alkali to neutralize, flowing water dialysis, concentration, and adding ethanol makes system ethanol
Mass content is 75%~85%, and precipitation is freeze-dried to obtain blue or green bur polysaccharide.
8. preparation method according to claim 7, it is characterised in that：In step (1), the solvent is petroleum ether, step
(1) it is embodied as follows：Blue or green bur seed is taken, is dried, is crushed, is extracted three times with petroleum ether soaking at room temperature, 6~8 is soaked every time
My god, after the completion of immersion, petroleum ether extract is concentrated in vacuo, and is reclaimed petroleum ether, prinsepia utilis royle oil is obtained, after being extracted through petroleum ether
Oil meal, volatilization removes the petroleum ether of residual completely, stand-by.
9. preparation method according to claim 7, it is characterised in that：In step (2), make the de- albumen at 0~5 DEG C
Carry out, the dialysis time is 30~60 hours, the ethanol of the addition is the ethanol of volumn concentration 95%.
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| CN105919842A (en) * | 2016-03-29 | 2016-09-07 | 高小娜 | Prinsepiautilisroyle body cleaner |
| CN106691942B (en) * | 2017-01-24 | 2021-04-02 | 广州市科能化妆品科研有限公司 | Sunscreen repair cosmetic composition and preparation method and application thereof |
| CN109260057A (en) * | 2018-11-08 | 2019-01-25 | 妃瑶生物科技（上海）有限公司 | A kind of extracting method of prinsepia utilis royle oil composition |
| CN109364132B (en) * | 2018-12-20 | 2021-04-27 | 文山合丰生物科技有限公司 | Method for extracting effective components from prinsepia utilis royle |
| CN109700909A (en) * | 2019-03-19 | 2019-05-03 | 孟召阳 | A kind of preparation method of quick-acting plaster |
| CN114699355B (en) * | 2022-06-07 | 2022-08-26 | 云南英格生物技术有限公司 | Anti-allergy composition of prunus humilis bunge and preparation method and application thereof |
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| CN102406576A (en) * | 2011-10-28 | 2012-04-11 | 何黎 | Prinsepia utilis Royle oil-containing functional skin care product and preparation method thereof |
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| JP2005232084A (en) * | 2004-02-19 | 2005-09-02 | Kin Din | Blood lipid-depressing agent, method for producing the same and healthy food having blood lipid-depressing activity |
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| CN102406576A (en) * | 2011-10-28 | 2012-04-11 | 何黎 | Prinsepia utilis Royle oil-containing functional skin care product and preparation method thereof |
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