CN108403535A - Purple perilla tender leaf extract and its application - Google Patents
Purple perilla tender leaf extract and its application Download PDFInfo
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- CN108403535A CN108403535A CN201810587172.1A CN201810587172A CN108403535A CN 108403535 A CN108403535 A CN 108403535A CN 201810587172 A CN201810587172 A CN 201810587172A CN 108403535 A CN108403535 A CN 108403535A
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- purple perilla
- tender leaf
- skin
- leaf extract
- moisture
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
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- Life Sciences & Earth Sciences (AREA)
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- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Birds (AREA)
- Epidemiology (AREA)
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- Microbiology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The present invention provides a kind of preparation method of purple perilla tender leaf extract, the method is selected from the group：Decoction, refluxing extraction, dipping, diacolation and combination thereof；Extraction solvent is selected from：Water, ethyl alcohol, polyalcohol and the similar solvent of other polarity or combination thereof.The invention also discloses purple perilla tender leaf extracts as having effects that application of the moisture-keeping function additive in skin preparations for extenal use and include the skin preparations for extenal use of purple perilla tender leaf extract.
Description
Technical field
The present invention relates to field of plant extraction, and in particular to purple perilla tender leaf extract and its answering in terms of skin moisture-keeping
With.
Background technology
Skin refers to tissue of the body surface packet outside muscle, is the maximum organ of human body, mainly carries protection body
Body perspires, feels the functions such as cold and hot and pressure.Skin covers whole body, and it is micro- from cause of disease to protect in human body respectively tissue and organ
The invasion of the mechanical damages such as the external substances such as biology and physics, effectively resist environmental stimuli；Skin also maintains human body
The loss of moisture, electrolyte and nutriment etc. effectively maintains the stabilization of human internal environment, is the natural screen for protecting human body
Barrier.
The skin emolliency of health, smooth, high resilience, this is largely attributed to the fact that moisture sufficient in skin, skin
Water content it is very high, account for the 18-20% of whole body weight.When moisture content of skin is less than 10%, just will appear it is dry, coarse very
To being chapped from the cold, and environmental drying, skin water oil is unbalance, the cleaning reasons such as excessively can all lead to skin dehydration.When the excessive dehydration of skin
When, skin barrier can be broken, prevent it from playing the role of being sufficiently reserved moisture.Skin moisture insufficient for a long time, can lead
Dry skin is caused, accelerates skin aging, various skin problems then occurs；In addition moisture content of skin is sufficient or improves
Skin physiology environment, the prerequisite for promoting skin metabolism.Therefore, keep the moistening of skin outstanding in skin daily nursing
It is important.
Currently, there are two types of skin moisture-keeping approach, one is the losses for preventing moisture, and one is the absorptions to moisturize.Just
In the case of often, skin must first absorb sufficient moisture, then sufficient moisture is preserved.Therefore, moisture absorption is skin moisture-keeping
Prerequisite.Combination of the moisture absorption of skin mainly by the moisture absorption factor and hydrone inside skin and in external use skin care is complete
At.Strong with water molecules power, moisture absorption amount is larger, and moisture-keeping function is good.
Recently as consumer to the growing interest of own health and safety, the cosmetics relative to many biochemical synthesis
Effect raw material, it is distinguished from natural, effect and can be more favored by daily edible raw material.
The red Soviet Union of purple perilla (Perilla frutescens (L.) Britt.) alias, red Soviet Union, purple Soviet Union, fragrant Soviet Union, are Labiatae
Perilla annual herb plant, be the traditional drug-food plant in China and health ministry is promulgated in the first batch be both food again
It is one of 60 kinds of articles of drug.Purple perilla exists as a kind of Chinese traditional herbs with more than one thousand years applicating history, pharmacological action
It is in successive dynasties works to record more.Property pungent-warm；Return lung, the spleen channel.With inducing sweat and dispelling exogenous evils, effect during promoting the circulation of qi is wide.Purple perilla not still medicine
Food dual purpose plant, and it is important industrial crops.Because of its distinctive active material and nutritional ingredient, becomes one kind and receiving the world
The multi-purpose plant of concern, in nutrition and health care, iundustrial oil, perfume industry, food antiseptic, flavoring agent exploitation, nectar source production etc.
Aspect has the value of higher utilization.Modern scientific research show perilla leaf contain protein, flavonoids, terpene,
The chemical compositions such as phenolic acid class, pigment, essential oil.The flavonoids and polyphenol components contained in perilla leaf can effectively remove oxygen
Free radical plays senile-resistant efficacy.Containing volatile oil, flavones ingredient and carotenoid etc. in perilla leaf, to large intestine bar
Bacterium, staphylococcus aureus have certain inhibiting effect.
The present invention investigates the moisture-keeping function and purple perilla and purple perilla of purple perilla and purple perilla tender leaf for the first time using purple perilla as research object
The power of tender leaf moisture-keeping function.It is an unexpected discovery of the invention that purple perilla tender leaf extract has excellent moisture-keeping function, it can conduct
Functional additive is added in skin preparations for extenal use and realizes moistening effect.
Invention content
Present invention firstly discovers that purple perilla tender leaf extract has excellent moisture-keeping function, it is suitable as functional additive addition
Moistening effect is realized in skin preparations for extenal use.Purple perilla tender leaf extract of the present invention can preferably keep moisture of skin, favorably
In the moisture-keeping function of skin.Purple perilla tender leaf extract is also used as functional additive and is added in cosmetics to use simultaneously, uses
In skin nursing, influence of the drying factor to skin is reduced.
The evaluation method that this research uses mainly is placed in the drier of constant temperature and humidity with the sample containing certain moisture and is done
Dry, timing weighs the increase of sample quality, weighs up the moisture-holding capacity of sample, by comparative analysis, compares different sample moisture retentions
Size.The moisture-keeping efficacy additive screened in the way of this, preferably keeps moisture of skin, is conducive to the guarantor of skin
Wet effect.
On the one hand, the present invention provides a kind of preparation method of purple perilla tender leaf extract, the method is selected from the group：It decocts
It boils, refluxing extraction, dipping, diacolation and combination thereof.
In a preferred embodiment, the Extraction solvent that purple perilla tender leaf extract of the invention uses is selected from：Water, ethyl alcohol,
Polyalcohol and the similar solvent of other polarity or combination thereof.In preferred embodiment, what extraction process used
Extraction solvent can be the ethyl alcohol of 60-90 (v/v), the ethyl alcohol of the present invention preferably 80% (v/v).
On the other hand, the present invention provides a kind of purple perilla tender leaf extracts extracted using the method for the invention.
On the other hand, the application the present invention provides the purple perilla tender leaf extract in skin moisture-keeping.
On the other hand, the present invention provides the purple perilla tender leaf extracts in the skin preparations for extenal use with skin moisture-keeping effect
In application.
In a preferred embodiment, the skin preparations for extenal use is selected from：Mildy wash, toner, lotion, cream, facial mask.
On the other hand, the present invention provides a kind of skin preparations for extenal use, and it includes purple perilla tender leaf extracts of the present invention.
In a preferred embodiment, weight percent of the extract in skin preparations for extenal use is 0.0001%-20% (w/w).
In one preferred embodiment, weight percent of the extract in skin preparations for extenal use is 0.001%-20% (w/
w).In one preferred embodiment, weight percent of the extract in skin preparations for extenal use is 0.001%-10%
(w/w).In one preferred embodiment, weight percent of the extract in skin preparations for extenal use is 0.01-1 (w/
w).In one preferred embodiment, weight percent of the extract in skin preparations for extenal use is 0.01-0.3 (w/
w)。
Detailed description of the invention
The definition of perilla leaf (also referred to as purple perilla old leaf) includes：High 30~100cm, leaf grow 4~11cm, wide 2~10cm, color
It is purple, not broken, fragrance is dense, without branch obstruct.
The definition of purple perilla tender leaf includes：Picking is from high 4.5~18cm, and tool 3-6 is to blade.
The purple perilla tender leaf extract of the present invention can be as the additive application with moisture-keeping efficacy in skin preparations for extenal use, guarantor
Health food and medicine.In a specific embodiment, purple perilla tender leaf extract of the invention, which can be used as, has moisturizing work(
The additive application of effect is in cosmetics.In a specific embodiment, the cosmetics are selected from：Mildy wash, toner,
Lotion, cream, gel, facial mask.Different dosages is added according to the different type of preparation.
In some preferred embodiments, the dosage of purple perilla tender leaf extract can be in the skin preparations for extenal use
0.001%-20% (w/w).Preferred weight percent is 0.01%-20% (w/w).Preferred weight percent is
0.01%-10% (w/w).Preferred weight percent is 0.1%-5% (w/w).In some preferred embodiment party of the invention
In formula, the dosage of purple perilla tender leaf extract can be 0.001%-10% (w/w), 0.002%-10% in the skin preparations for extenal use
(w/w), 0.003%-10% (w/w), 0.01%-10% (w/w), 0.02%-10% (w/w), 0.03%-10% (w/w),
0.1%-10% (w/w), 0.2%-10% (w/w), 0.3%-10% (w/w).In some preferred embodiments of the invention,
The dosage of purple perilla tender leaf extract can be 0.001%-1% (w/w), such as 0.002%-1% (w/ in the skin preparations for extenal use
W), 0.003%-1% (w/w), 0.01%-1% (w/w), 0.02%-1% (w/w), 0.03%-1% (w/w), 0.1%-1%
(w/w), 0.2%-1% (w/w), 0.3%-1% (w/w).
In another aspect of this invention, a kind of skin preparations for extenal use with moisture-keeping efficacy, the skin preparations for extenal use are provided
Including the purple perilla tender leaf extract and the acceptable excipient of cosmetic field that are prepared according to the method for the present invention.
The skin preparations for extenal use is typically used for the general designation concept of all the components outside skin, such as can be cosmetic preparation
Composition or pharmaceutical compositions.Can be foundation make up material, facial dressing cosmetic preparation, body in the cosmetic combination
Makeup material, hair nursing cosmetic preparation etc. can be reasonably selected to its dosage form without specifically limited according to different purposes.
Bu Tong also contain what different cosmeceutical levels allowed according to dosage form and purpose in the cosmetic combination
Medium or matrix excipients.
It can be used for cosmetics, dermatology or the pharmaceutically acceptable excipient of Dermatologic preparation composition of the present invention
For water phase, oil phase, gel, water packet wax pattern lotion, the form of emulsion oil-in-water or water-in-oil emulsion.Water phase is a kind of or more
The mixture of the water-soluble or dispersed component of kind, can be liquid, semisolid or solid under room temperature (25 DEG C).Excipient packet
It includes or can be the form of suspension in water or water-alcohol excipient, dispersion liquid or solution, thickener or solidifying can be contained
Jelly.The suitable product form of knowledge-chosen that those skilled in the art can be grasped based on those skilled in the art, wherein wrapping
The component contained.
The composition may include water phase, which can contain water or water and at least one hydrophilic organic solvent
Mixture, the hydrophilic organic solvent such as alcohol, the rudimentary unitary of linear chain or branched chain especially containing 2-5 carbon atom
Alcohol, such as ethyl alcohol or propyl alcohol；Polyalcohol, such as propylene glycol, sorbierite, glycerine, panthenol or polyethylene glycol and its mixture.
When the composition of invention is emulsion form, the composition can also optionally include surfactant.
The composition can also include film forming polymer, such as polyurethanes, polyacrylic acid homopolymer or copolymerization
Object, polyester, resin and/or silicone resin based on hydrocarbon.It can dissolve a polymer in or be scattered in the acceptable tax of cosmetics
Optionally merge in shape agent and with plasticizer.
The composition of the present invention can also include oil phase, and the oil phase contains molten for the oil of liquid under room temperature (25 DEG C)
Property or oil-dispersing property component and/or at room temperature be oily or wax-like substance, such as wax, semisolid, natural gum and its mixture.It should
Oil phase can also contain organic solvent.
Usually it is liquid at room temperature, suitable oily matter includes：From the oil based on hydrocarbon of animal, such as perhydrogenating
Squalene；Vegetable oil based on hydrocarbon, such as the triglyceride of the C4-10 aliphatic acid of liquid, such as enanthic acid or Trivent OCG
Class, or oil, such as sunflower oil, corn oil, soybean oil, grape seed oil, castor oil, avocado oil, caprylic/capric triglyceride
Class, jojoba oil；The linear chain or branched chain hydro carbons of mineral or synthesis source, such as liquid paraffin and its derivant, vaseline；Synthesis
The esters of esters and ethers, especially fatty alcohol, such as isopropyl myristate, palmitic acid 2- ethylhexyls, stearic acid 2- are pungent
Base dodecyl ester, isostearyl isostearate ester；Hydroxylating esters, for example, lactic acid isooctadecanol ester, octyl hydroxystearate,
Octyl hydroxystearate, hydroxy stearic acid octyldodecyl, the enanthic acid esters of fatty alcohol, sad esters and capric acid lipid；
Polyalcohol esters, such as propylene, two heptanoate of neopentyl glycol, two isononoate of diethylene glycol (DEG) and pentaerythritol ester
Class；Aliphatic alcohols containing C12-26, such as octyldodecanol, 2- butyl octanol, 2- hexyl decyl alcohols, 2- undecyls 15
Alkanol, oleyl alcohol；Fluorocarbon oil based on part hydrocarbon and/or fluorosilicon oil, silicone oil are at room temperature liquid or semisolid volatility or non-
Volatile straight chain or cyclo-methicone, such as X 2-1401 and dimethyl silicone polymer, optionally
Including phenyl, such as Silicone DC 556, siloxanes and its mixture.
The composition of the present invention can further include any component being usually used in cosmetic field.These components include
Preservative, water phase thickener (extract biopolymer, synthetic polymer) and fatty phase thickener, aromatic, hydrophily and
Lipophilic active agent and its mixture.
The composition of the present invention can also include other particle phase, and the particle can be mutually in cosmetic composition
The pigment and/or pearling agent and/or filler used.
Pigment can reside in composition, and suitable inorganic pigment includes titanium oxide, zirconium oxide and cerium oxide and oxygen
Change zinc, iron oxide and barba hispanica；Suitable organic pigment includes barium, strontium, calcium and aluminum lake and carbon black.
Pearling agent can reside in composition, and suitable pearling agent includes being coated with titanium oxide, iron oxide or natural face
The mica of material.
Filler can reside in composition, and suitable filler includes talcum powder, silica, zinc stearate, cloud
Mother, kaolin, nylon powder, polyethylene powders, Teflon, starch, borazon, copolymer microsphere, such as silicone resin
Microballon.
The oil phase of the present composition can include or mixtures thereof one or more waxes, natural gum.Wax includes based on hydrocarbon
Wax, fluorine wax and/or siloxane wax, and plant, mineral, animal and/or synthesis source can be derived from.Suitable wax includes bee
Wax, Brazil wax, candelila wax, paraffin, microwax, ceresine；Synthetic wax includes polyethylene wax, the siloxanes containing C16-45
Wax.Natural gum is generally dimethyl silicone polymer or sodium carboxymethylcellulose or extraction species, and semi-solid material is generally base
In the compound of hydrocarbon, such as lanolin and its derivative.
The composition of the present invention can be configured to any suitable product form.This kind of product form includes, but unlimited
In aerosol spray, creme, lotion, solid, liquid, dispersion, foam, gel, toner, mousse, ointment, pulvis,
Patch, brilliantine, solution, hand press pump spray, club, facial mask and hygenic towelette.The composition of the present invention can be passed through
Various methods well-known in the art are advantageously available for preparing or be produced as cosmetics, dermatology or drug local application
Product.
The Dermatologic preparation composition of the present invention may include one or more following ingredients：It is anti-allergic agent, antimicrobial
Agent, antioxidant, chelating agent, colorant depigmentation, emollient, emulsifier, excoriation agent, film forming agent, fragrance, moisturizing
Agent, lubricant, pharmaceutically active agents, humidizer, photostabilizer, preservative, skin conditioner, skin penetration enhancer, is prevented insect repellent
Shine agent, stabilizer, surfactant, thickener, viscosity modifier, vitamin or its arbitrary combination.
Specific implementation mode
Purple perilla tender leaf extract is not directed in document has effects that skin moisture-keeping, does not also refer to as with moisturizing
The additive of function is added in cosmetics.Present inventors discovered unexpectedly that：Purple perilla tender leaf extract has excellent guarantor
Wet effect can be added to skin preparations for extenal use as the additive with moisture-keeping efficacy, especially in cosmetics, be protected for skin
It is wet.
With reference to specific embodiment, the present invention is further explained.It should be appreciated, however, that these embodiments are only used for
It is bright the present invention and be not meant to limit the scope of the invention.The test method of actual conditions is not specified in the following example, usually
According to normal condition, or according to the normal condition proposed by manufacturer.Unless otherwise indicated, all percentage and number be by weight
Meter.
The purple perilla tender leaf used in following embodiment is provided to be commercially available by Shanghai Gao Xinhua glass Instrument Ltd.；Purple perilla
Leaf (also referred to as purple perilla old leaf) is commercially available, is provided by Shanghai Gao Xinhua glass Instrument Ltd..
Embodiment 1：The preparation of purple perilla tender leaf extract
Purple perilla tender leaf 100g is weighed, is impregnated 24 hours with 10 times of 80% ethyl alcohol, filter paper filtering, filtrate water-bath at 55 DEG C is returned
Stream is concentrated into 100g, and 4 DEG C stand 12 hours.Then, it at 4 DEG C, is centrifuged 15 minutes under the conditions of 10000rpm, filter paper filtering, filtrate
Water-bath reflux concentration, obtains 7.28g purple perilla tender leaf extracts at 55 DEG C, spare.
Embodiment 2：The preparation of perilla leaf extract
Perilla leaf 100g is weighed, is impregnated 24 hours with 10 times of 80% ethyl alcohol, filter paper filtering, filtrate water-bath at 55 DEG C flows back
It is concentrated into 100g, 4 DEG C stand 12 hours.It at 4 DEG C, is centrifuged 15 minutes under the conditions of 10000rpm, filter paper filtering, filtrate is at 55 DEG C
Water-bath reflux concentration, obtains 5.02g perilla leaf extracts, spare.
Embodiment 3：The moisturizing of purple perilla (tender) leaf extract is evaluated
Embodiment 1 purple perilla tender leaf extract 0.1g and 2 perilla leaf extract 0.1g of embodiment are weighed, small plate is respectively placed in
In, it is put into RH80% driers, the accurate weighing example weight after 24 hours, 48 hours, 72 hours, 96 hours, repeats 3
It is secondary.The water absorption rate of every sample is calculated by placing the weight difference of front and back sample, it is outer come comparative sample absorption by water absorption rate size
The ability of boundary's moisture, water absorption rate is bigger, and expression moisture sorption effect is better.
Hydroscopicity (%)=(M2-M1)/M1 × 100%
M1 --- sample dry weight (g) before moisture absorption
M2 --- example weight (g) after moisture absorption
Table 1
Hydroscopicity Vitro Experimental Results show that purple perilla (tender) leaf has in various degree under different humidity exposure times, to moisture
Absorption.Under identical humidity exposure time, such as 24 hours, the hydroscopicity of purple perilla tender leaf was 2.33 times of the hydroscopicity of perilla leaf；Such as 48 is small
When, the hydroscopicity of purple perilla tender leaf is 2.03 times of the hydroscopicity of perilla leaf；Such as 72 hours, the hydroscopicity of purple perilla tender leaf was perilla leaf
1.93 times of hydroscopicity；Such as 96 hours, the hydroscopicity of purple perilla tender leaf was 1.87 times of the hydroscopicity of perilla leaf, illustrates perilla leaf and purple perilla
Tender leaf all has certain moisture retention, and the moisture retention of purple perilla tender leaf is stronger than perilla leaf.
The purple perilla tender leaf extract prepared in Example 1 is used for the preparation of skin preparations for extenal use.The skin preparations for extenal use is excellent
It is selected as cosmetic composition, such as toner, Essence, creams etc..The purple perilla tender leaf extract 0.001%-20% (w/
w).Preferred weight percent is 0.01%-20% (w/w).Preferred weight percent is 0.01%-10% (w/w).Most
Preferred weight percent is 0.1%-5% (w/w).
It is the embodiment and its these dosage forms of the concrete application containing purple perilla tender leaf extract in skin preparations for extenal use below
Formula and preparation method."-" indicates no added in following table.
Embodiment 4：The preparation of moisturiser
| Ingredient | % concentration (weight) |
| Purple perilla (tender) leaf extract | 1.0 |
| Glyceryl stearate citrate | 4.0 |
| Stearine | 2.0 |
| Cetostearyl alcohol | 2.0 |
| Mineral oil | 10.0 |
| Caprylic/capric triglyceride | 5.0 |
| 1,3 butylene glycol | 7.0 |
| Preservative, essence | In right amount |
| Water | To 100.0 |
Preparation method：Purple perilla (tender) leaf extract first is dissolved with 1,3-BDO, is then added in water, stirs evenly,
Obtain water phase.By Glyceryl stearate citrate, stearine, cetostearyl alcohol, caprylic/capric triglyceride, mine
Object oil is added in oil phase pot, is heated to 75 DEG C -80 DEG C, stirs evenly, obtains oil phase.Oil phase is slowly added in water phase, not
Stop stirring, uniformly after preservative and essence is added, stir evenly to get.
Embodiment 5：The preparation of lotion
Embodiment 6：The preparation of toner
Embodiment 7：The preparation of Essence
Embodiment 8：The preparation of facial mask
Embodiment 9：The preparation of eye cream
Embodiment 10：The preparation of aerosol (cleaning bubble)
Embodiment 11：The preparation of spraying
Embodiment 12：The preparation of shower cream
Embodiment 13：The preparation of facial cleanser
Claims (9)
1. a kind of preparation method of purple perilla tender leaf extract, the method are selected from the group：Decoction, refluxing extraction, dipping, diacolation with
And combination thereof.
2. the method as described in claim 1, which is characterized in that Extraction solvent is selected from：Water, ethyl alcohol, polyalcohol and other poles
The similar solvent of property or combination thereof.
3. the method as described in claim 1, which is characterized in that Extraction solvent is the ethyl alcohol that volumetric concentration is 80%.
4. the purple perilla tender leaf extract being prepared such as any one of claim 1-3 the methods.
5. application of the purple perilla tender leaf extract as claimed in claim 4 in skin moisture-keeping.
6. application of the purple perilla tender leaf extract as claimed in claim 4 in the skin preparations for extenal use with skin moisture-keeping effect.
7. application as claimed in claim 6, which is characterized in that the skin preparations for extenal use is selected from：Mildy wash, toner, lotion,
Cream, facial mask.
8. a kind of skin preparations for extenal use, it includes purple perilla tender leaf extracts as claimed in claim 4.
9. skin preparations for extenal use as claimed in claim 8, which is characterized in that the skin preparations for extenal use includes 0.001-20 weight %
Purple perilla tender leaf extract.
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| CN201810587172.1A CN108403535A (en) | 2018-06-08 | 2018-06-08 | Purple perilla tender leaf extract and its application |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810587172.1A CN108403535A (en) | 2018-06-08 | 2018-06-08 | Purple perilla tender leaf extract and its application |
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ID=63141567
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| CN110638702A (en) * | 2019-09-24 | 2020-01-03 | 中北大学 | Perilla essence hand cream and preparation method thereof |
| CN110664638A (en) * | 2019-09-24 | 2020-01-10 | 中北大学 | Perilla frutescens essence mask and preparation method thereof |
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| CN105012185A (en) * | 2015-07-28 | 2015-11-04 | 广州市科能化妆品科研有限公司 | Cosmetic and application of perilla extract in cosmetic as transdermal penetration enhancer |
| CN105055510A (en) * | 2015-09-14 | 2015-11-18 | 青岛大学 | Effective part of perilla leaf resisting hyperuricemia and preparation method and application thereof |
| CN107213048A (en) * | 2016-12-23 | 2017-09-29 | 翁绍瑀 | A kind of purple perilla skin care item and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110638702A (en) * | 2019-09-24 | 2020-01-03 | 中北大学 | Perilla essence hand cream and preparation method thereof |
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Application publication date: 20180817 |