JP2005232084A - Blood lipid-depressing agent, method for producing the same and healthy food having blood lipid-depressing activity - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a blood lipid-depressing agent hardly having side effects and effective for depressing the blood lipid. <P>SOLUTION: At least one of a fruit, a stem, a leaf or a root of Prinsepia utilis which is a plant of Rosaceae peculiar to the back country of Sichuan province is extracted by using a solvent such as petroleum ether. The extract of the Prinsepia utilis extracted thereby contains an unsaturated fatty acid and a fat-soluble vitamin, and when the extract as it is, concentrated or formed into a powder, or the like, is administered, effects of ameliorating hyperlipemia are provided. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  The present invention relates to a blood fat lowering agent effective for the improvement and prevention of hyperlipidemia, a method for producing the same, and a health food having a blood fat lowering action.

  Dietary therapy and exercise therapy are often used to treat so-called hyperlipidemia, where the amount of lipids dissolved in the blood is abnormally higher than the required amount. Therapy is used. As therapeutic agents, HMG-CoA reductase inhibitors, anion exchange resins, fibrate agents and the like are used (see Patent Document 1). In addition, taking herbal medicine may be attempted.

Sankyo Co., Ltd. “Basic knowledge of diseases to be seen”, searched on January 29, 2004, Internet <URL: http://www.sankyo.co.jp/medemiru/life/hl/hl13.html>

  These therapeutic agents can lower cholesterol and triglyceride levels, but due to the nature of the disease, they are often administered over a long period of time, so the side effects cannot be avoided. On the other hand, prescriptions suitable for individual symptoms and constitution are possible for traditional Chinese medicines, but the risk of side effects is low, but conversely, the effects are slow and small compared to the former therapeutic agents.

  Accordingly, the present invention provides a blood fat lowering agent capable of effectively lowering the level of cholesterol and triglycerides without worrying about side effects, a method for producing the same, and a health food having a blood fat lowering action. It is intended to do.

  In the present invention, the “Rhizobium tree” (Henkakuboku, also known as “Plum blossom”, nickname “Blue stab”, scientific name “Prinsepia Utilis Royle”), which is peculiar to the outback of Sichuan Province, China, is used. This extract from a flat-nuclear tree contains many kinds of biologically active substances such as unsaturated fatty acids essential for human body and fat-soluble vitamins A, D, E, and K. In particular, linoleic acid, linolenic acid, The proportion of the three types of unsaturated fatty acids of arachidonic acid is 1: 1: 0.8.

  Accordingly, the applicant has focused on the tabular wood having the above components and has come up with the idea of using the tabular wood as a blood fat lowering agent. That is, in order to achieve the above-mentioned object, as described in claim 1, an invention of a blood fat lowering agent comprising an extract of a tabular tree as an active ingredient and The invention is based on the invention of a method for producing a blood fat lowering agent in which an active ingredient is extracted by adding a predetermined solvent to at least one of fruits, stems, leaves, and roots.

In addition to the object of claim 2, the invention described in claim 3 is a method for concentrating the extracted active ingredient into a paste to obtain an effective blood fat lowering effect even when taken in a small amount. The production method involves drying and pulverizing.
On the other hand, the invention according to claim 4 combines the blood fat lowering agent according to claim 1 and a predetermined food in order to make it possible to ingest the extract of the tabular tree more naturally. Thus, the health food has a blood fat lowering action.

According to the present invention, the values of cholesterol and neutral fat are effectively reduced by unsaturated fatty acids and fat-soluble vitamins, etc. contained in the extract of nucleated wood, which is suitable for the improvement of hyperlipidemia. In addition, effects such as regulation of blood pressure, prevention of arteriosclerosis, elimination of toxins, and improvement of constipation are also obtained. Of course, there are no side effects. In particular, according to the invention of claim 4, in addition to these effects, by blending with a predetermined food to make a health food, it becomes possible to naturally ingest the extract of a flatwood tree without resistance, and hyperlipidemia The effect by applying to the diet can be expected.
According to the third aspect of the invention, in addition to the effect of the second aspect, the concentrated extract pulverized product is not only convenient for handling and taking, but also effective for lowering blood fat. Can be obtained.

  First, a tabular tree is collected, and an active ingredient is extracted from at least one of the fruit, stem, leaf, and root of the tabular tree using a predetermined solvent. As the solvent, petroleum ether, alcohols such as methanol and ethanol, hexane, cyclohexane, water and the like are used. As the extraction method, a reflux extraction method using a Soxhlet extractor or the like is often employed. The extraction time is preferably 1 to 5 hours, and the extraction temperature may be room temperature or may be heated at about 70 ° C to 80 ° C. Further, the extraction operation is not limited to once, and may be performed a plurality of times, and the solvent and the extraction method may be changed in the second and subsequent extraction operations. In addition, after concentrating this extract with a vacuum concentrator or the like to make a paste (concentrated extract), it may be dried and pulverized into a powder.

  The extract (extracted solution or concentrated extract) of the tabular tree extracted in this way becomes a blood fat lowering agent. This may be taken as it is or in the form of tablets or capsules. By taking this, the value of serum total cholesterol and TG (neutral fat) decreases, and hyperlipidemia can be improved. In addition, since blood pressure can be adjusted and effects such as prevention of arteriosclerosis, elimination of toxins, and improvement of constipation can be expected, a wide range of medical and health effects can be obtained.

  On the other hand, it can also be set as the health food with a blood fat lowering effect by mix | blending this extract of a flat nucleus tree and another food in a predetermined ratio. As a blending ratio, for example, about 1 to 50% by weight of the whole food is desirable, but a value outside this range can be selected according to the type of food. In addition, examples of the form of blending include powdered and granulated granules, tablets, capsules, etc., but can also be blended into confectionery such as bread, noodles, jelly, dairy products, juices, and other foods. . If such a health food is used, it is possible to ingest an extract of a tabular tree without resistance in a daily meal, and a favorable effect can be expected if applied to a diet for hyperlipidemia.

  Examples of the present invention will be described below.

  After fresh or dried nucleated fruit is ground to a 20 mesh sieve, 100 g is placed in a Soxhlet extractor. Next, 200 ml of petroleum ether (30-60) is put into a solvent flask of a Soxhlet extractor, and extraction is performed by refluxing the solvent for 2 hours while heating at 70 ° C. with a heating device. Then, petroleum ether is collect | recovered and an extract (silent-nuclear wood oil) is obtained. In this example, 28 g of tabular wood oil was obtained.

  Instead of petroleum ether in Example 1, n-hexane is used as a solvent. The subsequent steps were the same as in Example 1. In this case, 28 g of tucrose oil was obtained.

  72 g of the fruit cake of the tabular tree used in Examples 1 and 2 is put into a Soxhlet extractor, and 200 ml of 80% alcohol is used as a solvent. Extraction was performed by refluxing the solvent for 4 hours to recover the alcohol, and the extract was concentrated with a vacuum concentrator to form a paste, and then the concentrated extract was dried, crushed to a 100-mesh sieve, A powder of nuclear wood extract was obtained.

  4 kg of the fruit residue remaining in Example 3 is placed in a Soxhlet extractor, 6 L of non-ionized water is placed in a solvent flask, and extraction is performed by refluxing the solvent for 4 hours. Thereafter, when filtered with anhydrous alcohol, a white flocculent precipitate appears. This was filtered and concentrated, then dried and pulverized to obtain 740 g of a white powder (crude polysaccharide). The extraction yield was 18.5%.

  Here we use the stems of tabular wood. 4 kg of crushed stalks were extracted in the same manner as in Example 3, to obtain 0.048 kg of powder of concentrated extract of stalks. The extraction yield was 1.2%.

  3.4 kg of the stem residue generated in Example 5 was extracted in the same manner as in Example 4 to obtain 0.2964 kg of powder of concentrated extract of stalk nucleus stems. The extraction yield was 7.8%.

  Here we use leaves of tabular nucleus trees. 4 kg of dried leaves were extracted in the same manner as in Example 3 to obtain 0.06 kg of powder of concentrated extract of leaf of a tabular tree. The extraction yield was 1.5%.

  The leaf debris 3.94 kg produced in Example 7 was extracted in the same manner as in Example 5 to obtain 0.453 kg of powder of concentrated extract of the leaf of a tabular tree. The extraction yield was 11.5%.

[Test example]
55 patients with hyperlipidemia were randomly divided into two groups, and one group of soft capsules obtained by encapsulating the tabular wood oil obtained in Example 1 with a soft capsule base in one group. One day, 2 g was taken, and the other group was taken 1.2 g of a commercially available Chinese herbal medicine per person per day, and a blood biochemical blood test was conducted one month later.
As a result, in the group taking the soft capsule of tabular wood oil, 25 people recovered blood fat normally, and in the group taking blood oil, 11 people recovered blood fat normally. There was a significant difference in blood fat lowering effect between the groups (P <0.05). In addition, the side effect of an example was not seen in the group which took the soft capsule of tabular wood oil.

Claims (4)

  A blood fat lowering agent comprising an extract of a tabular nucleus as an active ingredient.   A method for producing a blood fat lowering agent, comprising adding a predetermined solvent to at least one of fruits, stems, leaves, and roots of a tabular nucleus tree to extract an active ingredient.   The method for producing a blood fat lowering agent according to claim 2, wherein the extracted active ingredient is concentrated to form a paste, and then dried and pulverized. A health food having a blood fat lowering action, comprising the blood fat lowering agent according to claim 1 and a predetermined food.