CN104507461A - 通过亲脂性前体药物的选定制剂和粘膜给药来提高加兰他敏的脑生物利用度 - Google Patents

通过亲脂性前体药物的选定制剂和粘膜给药来提高加兰他敏的脑生物利用度 Download PDF

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Publication number
CN104507461A
CN104507461A CN201380039870.3A CN201380039870A CN104507461A CN 104507461 A CN104507461 A CN 104507461A CN 201380039870 A CN201380039870 A CN 201380039870A CN 104507461 A CN104507461 A CN 104507461A
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chemical substance
treatment
medicament
cognitive impairment
diseases associated
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阿尔弗雷德·梅里克
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Neurodyn Life Sciences Inc
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Neurodyn Life Sciences Inc
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Priority to CN201810140325.8A priority Critical patent/CN108245522A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
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    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
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    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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  • Pharmacology & Pharmacy (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Biomedical Technology (AREA)
  • Addiction (AREA)
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  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
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  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Physiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
CN201380039870.3A 2012-07-27 2013-07-29 通过亲脂性前体药物的选定制剂和粘膜给药来提高加兰他敏的脑生物利用度 Pending CN104507461A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810140325.8A CN108245522A (zh) 2012-07-27 2013-07-29 Gln-1062盐在制备治疗与认知障碍相关的脑疾病的药物中的应用

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261676348P 2012-07-27 2012-07-27
EP12178187 2012-07-27
US61/676,348 2012-07-27
EP12178187.6 2012-07-27
PCT/EP2013/065880 WO2014016430A1 (en) 2012-07-27 2013-07-29 Enhanced brain bioavailability of galantamine by selected formulations and transmucosal administration of lipophilic prodrugs

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201810140325.8A Division CN108245522A (zh) 2012-07-27 2013-07-29 Gln-1062盐在制备治疗与认知障碍相关的脑疾病的药物中的应用

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CN104507461A true CN104507461A (zh) 2015-04-08

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CN201380039870.3A Pending CN104507461A (zh) 2012-07-27 2013-07-29 通过亲脂性前体药物的选定制剂和粘膜给药来提高加兰他敏的脑生物利用度
CN201810140325.8A Pending CN108245522A (zh) 2012-07-27 2013-07-29 Gln-1062盐在制备治疗与认知障碍相关的脑疾病的药物中的应用

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CN201810140325.8A Pending CN108245522A (zh) 2012-07-27 2013-07-29 Gln-1062盐在制备治疗与认知障碍相关的脑疾病的药物中的应用

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US (1) US20150190401A1 (https=)
EP (2) EP3417862B1 (https=)
JP (2) JP6272857B2 (https=)
CN (2) CN104507461A (https=)
AU (1) AU2013294917B2 (https=)
CA (1) CA2878135C (https=)
DK (2) DK3417862T3 (https=)
ES (1) ES2700473T3 (https=)
HK (1) HK1206242A1 (https=)
IN (1) IN2015DN00229A (https=)
PL (2) PL3417862T3 (https=)
WO (1) WO2014016430A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116761612A (zh) * 2021-01-13 2023-09-15 阿尔法认知公司 α-1062葡糖酸盐的固体形式
CN119925285A (zh) * 2024-02-06 2025-05-06 阿尔法认知公司 包括苯加兰他敏的药物组合物及其用途和制备方法

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US20090253654A1 (en) 2005-09-22 2009-10-08 Galantos Pharma Gmbh Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment
ES2880399T3 (es) * 2012-07-27 2021-11-24 Neurodyn Life Sciences Inc Biodisponibilidad cerebral mejorada de galantamina mediante formulaciones seleccionadas y administración transmucosa de profármacos lipofílicos
AU2015258814B2 (en) 2014-05-16 2018-04-05 Synaptec Development Llc Clearance of amyloid ss
JP2020033304A (ja) * 2018-08-30 2020-03-05 医療法人ふじいやさか 薬剤又はサプリメント、組成物、及び水素供給器の使用
JP2022538608A (ja) * 2019-06-28 2022-09-05 ザ トラスティーズ オヴ ザ ユニヴァーシティー オヴ ペンシルバニア アルツハイマー病の治療のための鼻腔内ダントロレン投与
EP4337218A4 (en) * 2021-05-14 2025-01-22 Alpha Cognition Inc. SELF-PRESERVING COMPOSITIONS AND MULTI-PURPOSE DISPENSER FOR THE DELIVERY OF ALPHA-1062
EP4186509A1 (en) 2021-11-26 2023-05-31 Alpha Cognition Inc. Alpha-1062 for treating traumatic brain injury
JP2024541507A (ja) 2021-11-26 2024-11-08 アルファ コグニション インコーポレイティド 外傷性脳損傷を治療するためのａｌｐｈａ－１０６２
CN121443298A (zh) * 2023-05-25 2026-01-30 阿尔法认知公司 用于治疗持续性脑震荡后症状的苯加兰他敏
US12551491B1 (en) * 2025-07-23 2026-02-17 Alpha Cognition Inc. Dosage regimens for benzgalantamine

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US20090253654A1 (en) * 2005-09-22 2009-10-08 Galantos Pharma Gmbh Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment
CN102007129A (zh) * 2008-04-14 2011-04-06 加兰托斯医药有限责任公司 用作治疗人类脑疾病的前药的雪花胺衍生物

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CN1568184A (zh) * 2001-10-31 2005-01-19 辉瑞产品公司 烟碱乙酰胆碱受体激动剂在治疗多动腿综合征中的用途
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JP2009508903A (ja) * 2005-09-22 2009-03-05 ガラントス ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング 認知障害を伴う疾患の治療に用いるための脳血液関門透過性が改善されたコリン作用増強剤
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US20090253654A1 (en) * 2005-09-22 2009-10-08 Galantos Pharma Gmbh Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment
CN102007129A (zh) * 2008-04-14 2011-04-06 加兰托斯医药有限责任公司 用作治疗人类脑疾病的前药的雪花胺衍生物

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116761612A (zh) * 2021-01-13 2023-09-15 阿尔法认知公司 α-1062葡糖酸盐的固体形式
CN119925285A (zh) * 2024-02-06 2025-05-06 阿尔法认知公司 包括苯加兰他敏的药物组合物及其用途和制备方法

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PL2877165T3 (pl) 2019-05-31
HK1206242A1 (en) 2016-01-08
WO2014016430A1 (en) 2014-01-30
JP2015524423A (ja) 2015-08-24
EP3417862A1 (en) 2018-12-26
IN2015DN00229A (https=) 2015-06-12
ES2700473T3 (es) 2019-02-18
CN108245522A (zh) 2018-07-06
JP2018100272A (ja) 2018-06-28
EP2877165B1 (en) 2018-09-05
AU2013294917B2 (en) 2016-12-15
DK2877165T3 (da) 2019-01-02
US20150190401A1 (en) 2015-07-09
EP2877165A1 (en) 2015-06-03
PL3417862T3 (pl) 2021-11-22
JP6574002B2 (ja) 2019-09-11
EP3417862B1 (en) 2021-05-05
CA2878135A1 (en) 2014-01-30
JP6272857B2 (ja) 2018-01-31
AU2013294917A1 (en) 2015-01-22
CA2878135C (en) 2019-12-03
DK3417862T3 (da) 2021-07-12

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