CN1044970C - 鸡胆口服液的制备方法 - Google Patents

鸡胆口服液的制备方法 Download PDF

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CN1044970C
CN1044970C CN95117694A CN95117694A CN1044970C CN 1044970 C CN1044970 C CN 1044970C CN 95117694 A CN95117694 A CN 95117694A CN 95117694 A CN95117694 A CN 95117694A CN 1044970 C CN1044970 C CN 1044970C
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chicken
add
present
oral
oral liquor
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CN1149460A (zh
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张德桐
李雨晴
邵坤范
雷晓利
王春霖
戴金柱
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Zhanjiang Bokang ocean Biotechnology Co. Ltd.
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JILIN INSTITUTE OF BIOLOGY
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Abstract

本发明属于用于治疗咳嗽的鸡胆口服液的方法。
本发明选择资源丰富的鸡胆作原料，以精制的去蛋白鸡胆汁或鸡胆浸膏，添加蜂蜜、蔗糖、甜菊甙矫味剂制成口服液体药物制剂。具有镇咳、去痰、消炎、平喘作用。该口服液鹅去氧胆酸含量为0.01%至10.00%(W/V)，pH4.5～7.5。

Description

鸡胆口服液的制备方法
本发明属于用于治疗咳嗽的鸡胆口服液的制备方法。
咳嗽是由于呼吸道受到刺激如炎症，异物等，而引起的一种生理反射，对这类疾病的治疗，主要是排出呼吸道分泌物或异物，常用药物有可待因、咳必清，这类药多适用于无痰的干咳，对有痰的咳嗽一般不宜，甚至因影响痰液排出而加重病情，而且多伴随有口干、头晕、恶心、腹部不适等副作用，80年代上世的“蛇胆川贝液”临床反应较好，且有镇咳、祛痰作用，但因蛇作为保护动物，所以蛇胆资源日趋紧张，受限，且成本渐高。
本发明的目的是选择资源丰富的鸡胆作原料，以精制的去蛋白鸡胆汁或鸡胆浸膏，添加蜂蜜、蔗糖、甜菊甙矫味剂制成口服液体药物制剂，具有镇咳、祛痰、消炎、平喘作用。
本发明选择经检疫健康的新鲜或速冻的鸡胆汁，经浓缩至原体积1/3，然后加入95％乙醇使醇的浓度达50％-90％，过滤沉淀，滤液回收乙醇，得鸡胆浸膏，测定鹅去氧胆酸含量为0.01％至10.00％W/V,pH4.5-7.5，取2.5％W/V鸡胆浸膏50g，蜂蜜100g，蔗糖100g，甜菊甙5g，加水800ml，搅拌加热至溶解，添加2％W/V滑石粉，煮沸5分钟，加入对羟基苯甲酸乙酯0.5g，搅拌补足水量至1000ml，调pH4.5-7.5过滤分装，溶液为淡黄色澄清液体，味苦、微甜。
本发明制备的鸡胆口服液镇咳、祛痰、消炎、平喘作用确切，显著，治疗起效时间快，无副作用，原料丰富易得，是理想的止咳药品。
本发明提供的实施例如下：
实施例1：取经检疫健康的新鲜鸡胆汁加热浓缩至原体积的1/3，加入95％乙醇，使醇浓度达50％，过滤沉淀，取滤液回收乙醇，重复一次，得鸡胆浸膏，调整含量至2.5％W/V取2.5％W/V鸡胆浸膏50g，蜂蜜100g，蔗糖100g，水800ml，搅拌加热至溶解，添加2％W/V滑石粉，煮沸5分钟，加入羟基苯甲酸乙酯0.5g，搅拌，补足水量至1000ml，调节pH4.5过滤，分装得含鹅去氧胆酸0.11％W/V的淡黄色鸡胆的服液。
实施例2：
使醇浓度达70％,pH调至6，其余同实施例1，得鹅去氧胆酸含量0.11％W/V的黄色鸡胆口服液。
实施例3：
使醇浓度达90％,pH调至7.5，其余同实施例1，得鹅去氧胆酸含0.11％W/V的黄色鸡胆口服液。

Claims (1)

1．一种鸡胆口服液的制备方法，是取新鲜的鸡胆汁经浓缩，加乙醇，过滤得到浸膏，再加蜂蜜、蔗糖、甜菊甙水、加滑石粉煮沸加入对羟基苯甲酸乙酯补足水量得口服液，其特征在于该口服液的鹅去氧胆酸含量为0.11％W/V,PH4.5-7.5。
CN95117694A 1995-11-04 1995-11-04 鸡胆口服液的制备方法 Expired - Fee Related CN1044970C (zh)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1311838C (zh) * 2005-03-02 2007-04-25 吉林省东北亚药业股份有限公司 一种用于镇咳、祛痰、平喘、消炎的中药制剂

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010095366A (ko) * 2000-03-23 2001-11-07 김홍국 담즙에서 추출한 성분을 포함하는 기관지 이완 효능제
CN107468776A (zh) * 2017-08-31 2017-12-15 温美群 一种具有止咳作用的口服液及其制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1102326A (zh) * 1994-03-03 1995-05-10 昌邑县中医院 一种治疗小儿咳嗽的中药

Patent Citations (1)

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CN1102326A (zh) * 1994-03-03 1995-05-10 昌邑县中医院 一种治疗小儿咳嗽的中药

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1311838C (zh) * 2005-03-02 2007-04-25 吉林省东北亚药业股份有限公司 一种用于镇咳、祛痰、平喘、消炎的中药制剂

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