CN104491740B - 一种治疗肝癌的中药组合物及其制备方法 - Google Patents
一种治疗肝癌的中药组合物及其制备方法 Download PDFInfo
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Abstract
本发明提供一种低毒高效的治疗肝癌的中药组合物,其由以下重量份的26味中药组成:柴胡30‑60、斑蝥30‑60、佛手20‑40、莪术20‑40、姜黄30‑60、川芎20‑40、牡蛎20‑40、木香10‑30、陈皮30‑60、香附30‑60、昆布30‑60、白花蛇舌草30‑60、川楝子20‑40、芍药10‑30、蚤休10‑30、龙葵10‑30、蟾酥20‑40、山慈菇30‑60、龙胆草30‑60、麦冬30‑60、马钱子10‑30、大黄10‑30、麝香10‑30、海马20‑40、枳壳10‑30、甘草10‑30。在动物实验和临床实验上均取得了明显的抑制肝癌发展的效果,且副作用低,患者治疗痛苦小。
Description
技术领域
本发明涉及一种中药组合物,具体的涉及一种治疗肝癌的中药组合物及其制备方法。
背景技术
肝是五脏之一,其生理功能包括解毒、代谢、分泌胆汁、免疫防御等,肝脏对来自体内和体外的许多非营养性物质如各种药物、毒物以及体内某些代谢产物,具有生物转化作用,是人体的重要器官。肝癌即肝脏恶性肿瘤,目前我国是全球肝癌发病率最高和病死数最多的国家,而肝癌的发生是多因素、多步骤的复杂过程,受环境和因此双重因素影响,肝炎病毒的感染、黄曲霉素、饮水污染、酒精、肝硬化都与肝癌发病相关。
目前西医对于肝癌的治疗通常为手术治疗、放疗、化疗等。其中能够手术治疗的病人仅为早期肝癌,由于肝癌发现时多已是中晚期,且由于肝脏的重要作用,及肝脏原位移植的难度和成本,无法通过彻底切除肝脏以保证肝癌细胞的彻底切除,能够通过手术治疗的肝癌患者比例较低,手术切除后也不能解决肝内复发病灶或多中心病灶的清除问题,手术创口还可能会加剧未完全切除的肿瘤细胞向肝脏其他部位、甚至身体其他脏器的转移。因此,目前临床上西医多采用放疗、化疗的手段治疗肝癌。放疗、化疗所存在的主要问题是其过于严重的副作用,严重制约了临床上放疗、化疗对于肝癌的治疗效果,虽然目前对于肿瘤的靶向放疗、靶向化疗已取得了很大进展,一定程度上降低了放疗、化疗的副作用,但由于技术和成本等原因无法在我国肝癌患者中大面积使用,如曲妥珠单抗(赫赛汀)单支售价就已超过了两万元,使很多的中国癌症患者无力承担相关治疗费用。
从中医的角度肝脏主疏泄,藏血。中医虽本无肝癌之名,但 中医对肝癌的认识渊源已久,在中医理论中肝癌属于 “肝积”、“肝壅”、“肥气”、“痞气”、“积气”、“积聚”、“疒徵瘕”、“鼓胀”、“胁痛”、“黄疸”等范畴。论其病因病机《医宗必读・积聚篇》曰:“积之成也,正气不足,而后邪气踞之”。《诸病源候论・积聚病诸候》曰:“积聚者,由阴阳不和,脏腑虚弱,受于风邪,搏于脏腑之气所为也”。由此可见,肝癌的病因不外乎正气的不足和邪气的留滞,而以正气的虚弱为主,多表现为肝脾同病、气滞血瘀、湿热毒邪内蕴之证,晚期多表现为阴液枯竭、瘀毒互结、水湿内停之候。因此,“虚、瘀、毒”是肝癌发生、发展的三大关键因素。目前中药借助其源于天然、副作用低、价格低廉等优势已经开始用于肝癌等多种癌症的治疗,如柴胡疏肝散、茵陈蒿汤加减等,但其仅为临床放疗、化疗的辅助手段,效果主要体现于减轻肝癌患者疼痛,降低放疗、化疗副作用,提高患者生活质量,对于癌细胞的杀伤作用不明显。为了继续提高中药对于肝癌的治疗效果,应当在保持低毒的同时需要研究对于肝癌细胞具有更高杀伤作用的中药组合物。
发明内容
针对肝癌患者以气血亏虚为本,气血湿热瘀毒互结为标的虚实错杂的病机特点,本发明采用健脾益气、养血柔肝、滋补阴液的方法,提供了一种抗肝癌效果更好的中药组合物及其制备方法和应用。
一方面本发明提供了一种具有优异肝癌治疗效果的中药组合物,由以下重量份的原料药制成:
柴胡30-60、斑蝥30-60、佛手20-40、莪术20-40、姜黄30-60、川芎20-40、牡蛎20-40、木香10-30、陈皮30-60、香附30-60、昆布30-60、白花蛇舌草30-60、川楝子20-40、芍药10-30、蚤休10-30、龙葵10-30、蟾酥20-40、山慈菇30-60、龙胆草30-60、麦冬30-60、马钱子10-30、大黄10-30、麝香10-30、海马20-40、枳壳10-30、甘草10-30。
所述治疗肝癌的中药组合物,优选由以下重量份的原料药制成:
柴胡40-50、斑蝥40-50、佛手30-35、莪术30-35、姜黄40-50、川芎30-35、牡蛎30-35、木香15-25、陈皮40-50、香附40-50、昆布40-50、白花蛇舌草40-50、川楝子30-35、芍药15-25、蚤休15-25、龙葵15-25、蟾酥30-35、山慈菇40-50、龙胆草40-50、麦冬40-50、马钱子15-25、大黄15-25、麝香15-25、海马30-35、枳壳10-20、甘草10-20。
所述中药组合物,更优选的由以下重量份的原料药制成:
柴胡50、斑蝥50、佛手30、莪术30、姜黄40、川芎35、牡蛎35、木香15、陈皮40、香附40、昆布40、白花蛇舌草50、川楝子30、芍药25、蚤休25、龙葵15、蟾酥35、山慈菇50、龙胆草40、麦冬50、马钱子15、大黄15、麝香15、海马30、枳壳20、甘草20。
另一方面,本发明提供一种治疗肝癌的中药组合物的制备方法,包括以下步骤:
(1)备料,称取所述配比的原料药;
(2)粉碎,蟾酥、麝香粉碎备用;
(3)煎制,除蟾酥、麝香外,所有原料药加水5-10倍煎煮2-3小时,过滤,滤液备用,药渣继续加水5-8倍煎煮1-2小时,过滤得滤液,药渣弃去,两次滤液合并,减压浓缩至25℃时相对密度为1.2-1.3的浓缩液,加入蟾酥、麝香粉末,混合后即得。
本发明的有益效果:本发明提供的肝癌治疗中药组合物具有标本兼治,尤其具有明显加强的肝癌细胞抑制活性,可适合临床早、中、晚各期肝癌的治疗。
具体实施方式
下面结合具体实施例对本发明做进一步的说明。
实施例1 肝癌治疗中药组合物
称取如下重量份的中药:柴胡50、斑蝥50、佛手30、莪术30、姜黄40、川芎35、牡蛎35、木香15、陈皮40、香附40、昆布40、白花蛇舌草50、川楝子30、芍药25、蚤休25、龙葵15、蟾酥35、山慈菇50、龙胆草40、麦冬50、马钱子15、大黄15、麝香15、海马30、枳壳20、甘草20。
其中蟾酥、麝香粉碎,其余中药中加入8倍量的水倍煎煮2小时,过滤,滤液备用,药渣继续加5倍量的水煎煮1小时,过滤得滤液,药渣弃去,两次滤液合并,减压浓缩至25℃时相对密度为1.2的浓缩液,加入蟾酥、麝香粉末,混合后即得,分早晚两次服用。
实施例2肝癌治疗中药组合物
称取如下重量份的中药:柴胡30、斑蝥30、佛手20、莪术20、姜黄30、川芎20、牡蛎20、木香10、陈皮30、香附30、昆布30、白花蛇舌草30、川楝子20、芍药10、蚤休10、龙葵10、蟾酥20、山慈菇30、龙胆草30、麦冬30、马钱子10、大黄10、麝香10、海马20、枳壳10、甘草10。
其中蟾酥、麝香粉碎,其余中药中加入8倍量的水倍煎煮2小时,过滤,滤液备用,药渣继续加5倍量的水煎煮1小时,过滤得滤液,药渣弃去,两次滤液合并,减压浓缩至25℃时相对密度为1.2的浓缩液,加入蟾酥、麝香粉末,混合后即得,分早晚两次服用。
实施例3肝癌治疗中药组合物
称取如下重量份的中药:柴胡60、斑蝥60、佛手40、莪术40、姜黄60、川芎40、牡蛎40、木香30、陈皮60、香附60、昆布60、白花蛇舌草60、川楝子40、芍药30、蚤休30、龙葵30、蟾酥40、山慈菇60、龙胆草60、麦冬60、马钱子30、大黄30、麝香30、海马40、枳壳30、甘草30。
其中蟾酥、麝香粉碎,其余中药中加入8倍量的水倍煎煮2小时,过滤,滤液备用,药渣继续加5倍量的水煎煮1小时,过滤得滤液,药渣弃去,两次滤液合并,减压浓缩至25℃时相对密度为1.2的浓缩液,加入蟾酥、麝香粉末,混合后即得,分早晚两次服用。
实施例4 H22(肝癌)体内抑瘤活性实验
昆明小鼠体重19-22g,雌雄各半,随机分成6组,分别为对照组、实施例1组、实施例2组、实施例3组、柴胡疏肝散和紫杉醇组,每组10只,接种H22肝癌细胞,接种24小时后,腹腔给药,给药剂量均为100mg/kg/d,其中对照组为相同体积生理盐水,连续给药7d,停药24小时后称取小鼠体重,并处死小鼠,称取小鼠瘤重,计算抑瘤率、体重增长率;
抑瘤率=(1-实验组平均瘤重/对照组平均瘤重)×100%
体重增长率=(实验组平均体重/对照组平均体重-1)×100%
表1、肝癌治疗中药组合物对H22肝癌的体内抑制效果
表1试验结果显示了在H22的小鼠体内模型上,柴胡疏肝散的抑瘤作用不明显,而本发明的中药组合物取得了明显优于相同剂量的柴胡疏肝散的H22抑瘤率,并且其抑瘤率也仅稍低于本领域的经典抗癌药物紫杉醇。
表2肝癌治疗中药组合物对小鼠体重增长率的影响
表2的体重实验结果显示了给药7天后相对于对照组,本申请实施例1-3
及柴胡疏肝散组小鼠体重均有一定程度的增长,只有紫杉醇组小鼠体重低于对
照组,表明了本发明实施例1-3的中药组合物相对于紫杉醇组具有更低的副作用。
实施例6 典型病例
患者孙某,男,57岁,腹胀、疼痛,确诊为肝癌晚期,三次化疗后白细胞2800,体重减轻10公斤,恶心呕吐,无法继续进行化疗,后给予实施例1中药组合物每日一剂,分早晚两次服用,连续服用两个月后,腹胀、疼痛减轻,饮食正常,体重相对于最后一次化疗增长4公斤,白细胞4200,复查肝部阴影缩小。
患者李某,男,49岁,晚期肝癌,两次化疗后因恶心呕吐、体重减轻等副作用停止化疗,后给予实施例1中药组合物每日一剂,分早晚两次服用,连续服用两个月后,饮食正常,相对于最后一次化疗体重增长3公斤,复查肝部阴影缩小。
患者高某,女,62岁,晚期肝癌,三次化疗后副作用严重,恶心呕吐,体重减轻15公斤,白细胞3100,停止化疗,后给予实施例3中药组合物每日一剂,分早晚两次服用,连续服用两个月后,恶心呕吐消失,相对于最后一次化疗体重增长5公斤,复查肝部阴影缩小。
患者王某,女,67岁,晚期肝癌,四次化疗后肝癌复发,腹胀、疼痛,后给予实施例3中药组合物每日一剂,分早晚两次服用,连续服用两个月后,腹胀、疼痛减轻,复查肝部阴影缩小。
本发明中药组合物在动物实验与临床实验上均显示在较低的毒副作用基础上还具有了良好的肝癌治疗效果,可有效抑制肝癌的继续发展,减轻患者痛苦。
Claims (6)
1.一种治疗肝癌的中药组合物,其特征在于由以下重量份的原料药制成:柴胡50、斑蝥50、佛手30、莪术30、姜黄40、川芎35、牡蛎35、木香15、陈皮40、香附40、昆布40、白花蛇舌草50、川楝子30、芍药25、蚤休25、龙葵15、蟾酥35、山慈菇50、龙胆草40、麦冬50、马钱子15、大黄15、麝香15、海马30、枳壳20、甘草20。
2.如权利要求1所述的治疗肝癌的中药组合物,其特征在于由以下重量份的原料药制成:柴胡30、斑蝥30、佛手20、莪术20、姜黄30、川芎20、牡蛎20、木香10、陈皮30、香附30、昆布30、白花蛇舌草30、川楝子20、芍药10、蚤休10、龙葵10、蟾酥20、山慈菇30、龙胆草30、麦冬30、马钱子10、大黄10、麝香10、海马20、枳壳10、甘草10。
3.如权利要求1所述的治疗肝癌的中药组合物,其特征在于由以下重量份的原料药制成:柴胡60、斑蝥60、佛手40、莪术40、姜黄60、川芎40、牡蛎40、木香30、陈皮60、香附60、昆布60、白花蛇舌草60、川楝子40、芍药30、蚤休30、龙葵30、蟾酥40、山慈菇60、龙胆草60、麦冬60、马钱子30、大黄30、麝香30、海马40、枳壳30、甘草30。
4.如权利要求1-3任一项所述的治疗肝癌的中药组合物的制备方法,其特征在于包括如下步骤:(1)备料,称取权利要求1-3任一项所述配比的原料药;(2)粉碎,蟾酥、麝香粉碎备用;(3)煎制,除蟾酥、麝香外,所有原料药加水5-10倍煎煮2-3小时,过滤,滤液备用,药渣继续加水5-8倍煎煮1-2小时,过滤得滤液,药渣弃去,两次滤液合并,减压浓缩至25℃时相对密度为1.2-1.3的浓缩液,加入蟾酥、麝香粉末,混合后即得。
5.如权利要求4所述的治疗肝癌的中药组合物的制备方法,其特征在于:前后两次煎煮的加水量分别为8倍和5倍。
6.如权利要求4所述的治疗肝癌的中药组合物的制备方法,其特征在于25℃时浓缩液的相对密度为1.2。
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