CN104491737A - 一种治疗早期肝癌的中药配方 - Google Patents

一种治疗早期肝癌的中药配方 Download PDF

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CN104491737A
CN104491737A CN201410843100.0A CN201410843100A CN104491737A CN 104491737 A CN104491737 A CN 104491737A CN 201410843100 A CN201410843100 A CN 201410843100A CN 104491737 A CN104491737 A CN 104491737A
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潘振奎
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Abstract

本发明属于中医中药技术领域，特别涉及一种治疗早期肝癌的中药配方，由以下重量份数的中药原料配制而成：柴胡3-5份、蒲公英1-3份、蚤休2-4份、紫花地丁3-5份、佛手5-8份、玫瑰花5-8份、香橼3-5份、大蓟5-8份、郁金8-12份、莪术5-8份、三棱5-8份、黄药子5-8份、琥珀5-8份、牡蛎5-8份、沙苑子5-8份、鳖甲2-4份、田基黄2-4份、垂盆草2-4份、天南星1-3份、青皮1-3份、熟地2-4份、天冬1-3份、阿胶1-3份、墨旱莲1-3份和青木香1-3份，本发明通过中药的调理，舒肝解郁、补肾养阴，消癥散、清热解毒、活血化瘀、化痰利湿、软坚散结、补气养血和滋阴培元的功效，从而有效的治疗早期肝癌。

Description

一种治疗早期肝癌的中药配方
技术领域
本发明属于中医中药技术领域，特别涉及一种治疗早期肝癌的中药配方。
背景技术
肝癌是临床上最常见的恶性肿瘤之一，根据最新统计，全世界每年新发肝癌患者约六十万，居恶性肿瘤的第五位。肝癌在我国属于高发病，一般男性多于女性。中国是乙肝大国，我国的肝癌多在乙肝肝硬化的基础上发展而来，丙肝病人也在逐渐增加，乙肝后也会发展为肝癌。目前我国发病人数约占全球的半数以上，占全球肝癌病人的55％，已经成为严重威胁我国人民健康和生命的一大杀手，其危险性不容小视。而做好肝癌的早期诊断及治疗对于治疗肝癌非常重要。早期肝癌是指单个癌结节最大直径小于3cm或者两个癌结节合计最大直径小于3cm的原发性肝癌。肝癌的起病比较隐匿，早期一般没有任何症状，当患者出现明显的临床症状时，病情往往已属于中晚期。肝癌的典型症状发生率国内外报道基本相同，其首发症状以肝区疼痛最为常见，其次是上腹部包块。
肝癌的主要治疗方法有手术、放化疗及中药治疗，传统的治疗肝癌的方法是首选手术切除，但不是所有的肝癌患者都适合手术，只有心肺功能较好，肝脏肿瘤较局，没有转移条件的患者才适宜手术。中药治疗是近年来一个重要的肝癌治疗方法，不但具有抗肿瘤功效，还能提高人体免疫力。从而提高肝癌患者生活质量，延长病人生命，也是早期原发性肝癌治疗原则的保证。
发明内容
本发明提供一种治疗早期肝癌的中药配方，具有舒肝解郁、补肾养阴，消癥散、清热解毒、活血化瘀、化痰利湿、软坚散结、补气养血和滋阴培元的功效，从而有效的治疗肝癌，并可以治愈部分早期肝癌。
本发明的药物是由以下重量份数的中药为原料药制备获得的：
柴胡3-5份、蒲公英1-3份、蚤休2-4份、紫花地丁3-5份、佛手5-8份、玫瑰花5-8份、香橼3-5份、大蓟5-8份、郁金8-12份、莪术5-8份、三棱5-8份、黄药子5-8份、琥珀5-8份、牡蛎5-8份、沙苑子5-8份、鳖甲2-4份、田基黄2-4份、垂盆草2-4份、天南星1-3份、青皮1-3份、熟地2-4份、天冬1-3份、阿胶1-3份、墨旱莲1-3份和青木香1-3份。
本发明的中药配方，优选为按下述重量份数制备：柴胡4份、蒲公英2份、蚤休2份、紫花地丁4份、佛手6份、玫瑰花8份、香橼4份、大蓟8份、郁金10份、莪术6份、三棱6份、黄药子6份、琥珀6份、牡蛎6份、沙苑子8份、鳖甲3份、田基黄3份、垂盆草3份、天南星2份、青皮2份、熟地3份、天冬2份、阿胶2份、墨旱莲2份和青木香2份。
将上述各原料药制成本发明药物的具体制备方法是：
按上述重量份数取上述中药原料，琥珀、鳖甲、阿胶研末备用；将其他药材混合均匀，洗净，加水煎煮2次，每次加水量为药材重量的4～5倍，煎煮2～4h，合并煎液，并加入琥珀、鳖甲和阿胶粉末，得到本发明的治疗肝癌的中药汤剂。
用法：成人每次服用200-300mL，每日2次，饭后2小时温服，15天为一个疗程。
药理分析：
柴胡：苦，凉；微寒，无毒；入肝、胆经；疏肝解郁。
蒲公英：苦、甘、寒；肝、胃经；清热解毒、消肿散结。
蚤休：苦、寒；心、肝经；清热解毒，平喘止咳，熄风定惊；治痈肿，疔疮，瘰疬，喉痹，慢性气管炎，小儿惊风抽搐，蛇虫咬伤。
紫花地丁：苦、辛、寒；心、肝经；清热解毒、凉血消肿，用于痈肿疮毒、乳痈肠痈。
佛手：味辛、微苦，性温。肝、脾、胃、肺经。能舒肝解郁，理气和中，化痰。
玫瑰花：味甘微苦、性微温，归肝、脾、胃经。疏肝解郁、活血止痛。
香橼：辛、苦、酸、温；入肝、脾、胃经；具有疏肝理气，宽胸化痰，除湿和中；主治胸胁胀痛，咳嗽痰多，脘腹痞痛，食滞呕逆。
大蓟：甘、苦、寒；心、肝、胃经；活血止血、散瘀解毒、消痈。
郁金：辛、苦、寒；入心、肺、肝经；行气解郁，凉血破瘀。治胸腹胁肋诸痛，失心癫狂，热病神昏，吐血，衄血，尿血，血淋，妇女倒经，黄疸。
莪术：辛、苦，温。归肝、脾经；破血行气，消积止痛。用于血瘀腹痛、肝脾肿大、心腹胀痛，积聚，妇女血瘀经闭，跌打损伤作痛饮食积滞。
三棱：辛、苦，平。归肝、脾经。破血行气，消积止痛。用于症瘕痞块，瘀血经闭，食积胀痛。
黄药子：苦，辛，咸，性凉，有小毒。化痰散结，凉血止血。
琥珀：甘、平；入心、肝、膀胱经；镇静安神、活血散瘀、利尿通淋。
牡蛎：味咸；性微寒。重镇安神，潜阳补阴，软坚散结，收敛固涩。用于惊悸失眠，眩晕耳鸣，瘰疬痰核，徵瘕痞块，自汗盗汗，遗精崩带，胃痛泛酸。煅牡蛎收敛固涩。用于自汗盗汗，遗精崩带，胃痛吞酸。
沙苑子：甘、温；入肾、脾经；暖肾固精、缩尿、温脾开胃摄唾，用于下元虚寒、遗精遗尿、脾胃虚寒。
鳖甲：滋阴潜阳，软坚散结，退热除蒸。用于阴虚发热，劳热骨蒸，虚风内动，经闭，癓瘕，久疟疟母。
田基黄：甘、微苦，微寒。归肝、脾经。清热利湿；凉血活血；解毒消肿。主黄疸；泻痢；目赤；吐血；血淋；白带；崩漏；痛经；闭经；咽喉肿痛；痈肿疮毒；流火；瘰疬；跌打；蛇虫咬伤。
垂盆草：甘、淡，凉。有利湿退黄，清热解毒之功效。常用于湿热黄疸，小便不利，痈肿疮疡。
天南星：苦、辛，温；有毒。归肺、肝、脾经。燥湿化痰，祛风止痉，散结消肿。用于顽痰咳嗽，风痰眩晕，中风痰壅，口眼歪斜，半身不遂，癫痫，惊风，破伤风。生用外治痈肿，蛇虫咬伤。
青皮：苦、辛、寒；归肝、胆、胃经；有疏肝破气，消积化滞的功效。
熟地：甘，微温。归肝、肾经。补血养阴，填精益髓。
天冬：性寒，味甘，微苦。具有养阴清热，润肺滋肾的功效。
阿胶：补血滋阴，润燥，止血。用于血虚萎黄，眩晕心悸，心烦不眠，肺燥咳嗽。
墨旱莲：甘、酸寒。肝、肾经；滋补肝肾；凉血止血。
青木香：辛、苦、寒。肝、胃经；行气止痛、解毒消肿。
本发明的中药配方中，琥珀活血化瘀，利尿通淋；莪术、三棱、黄药子破血行气、消积止痛；辅以佛手、玫瑰花、郁金、柴胡、青皮、香橼疏肝解郁、消积止痛、活血、凉血、止血；活肝中之血瘀，行气散瘀，气血顺畅则肝脏软化；配伍蒲公英、垂盆草、紫花地丁入肝经，清热解毒，凉血消肿，镇静安神；鳖甲、牡蛎潜阳补阴，软坚散结，收敛固涩；阿胶、天冬、熟地、沙苑子壮肾阳、益肾精；肾水足则心神安定，疏泄功能正常，诸药合成，相得益彰，具有活血化瘀、行气导滞、软坚散结、疏肝解郁之功效，治疗肝癌具有显著的效果。
本发明以上述药物组方，具有舒肝解郁、补肾养阴，消癥散、清热解毒、活血化瘀、化痰利湿、软坚散结、补气养血和滋阴培元的功效，从而有效的治疗早期肝癌。
疗效判断：
一、临床观察
1、临床资料：选自2012年1月至2014年4月收治肝癌患者共200余例，其中早期肝癌患者100例纳入本研究范围，年龄为45-55岁，平均48岁。
2、诊断标准：以我国卫生部编的《中国常见恶性肿瘤诊治规范》中的原发性肝癌诊断标准为依据。其中，早期肝癌是指单个癌结节最大直径小于3cm或者两个癌结节合计最大直径小于3cm的原发性肝癌。
3、治疗用药：服用本发明药物制成的汤剂，分两次早晚服用，12天为1个疗程。
4、疗效评定标准：按照卫生部《中国常见恶性肿瘤诊治规范》中原发性肝癌疗效评定标准，以患者治疗前与治疗后B超或CT进行对照比较，以完全缓解(CR)、部分缓解(PR)、稳定(SD)、进展(PD)进行疗效评定。
5、治疗结果：完全缓解62例，部分缓解19例，稳定19例，进展0例。有效率(CR+PR)为81％，稳定率(CR+PR+SD)为100％。
附几例病例作进一步说明：
病例1：梁某某，男性，50岁，2013年3月前来就诊，自述腹部闷胀，消化不良，有时恶心、呕吐，发热，肝区持续性疼痛，经腹部CT检查发现肿瘤大小为2cm×3cm，确诊为肝癌早期，服用本发明的药物，两个疗程后，患者腹部闷胀、发热、恶心症状明显减轻，食欲增加，经检查肿瘤缩小为1cm×2cm，病情好转。继续服用6个疗程，肝区经检查肿瘤消失。随访1年无复发。
病例2：刘某某，男性，48岁，2013年5月前来就诊，患者自述肝区胀痛不适、食欲下降、消瘦4个月，B超、CT检查肝部发现肿瘤，约3×3cm大小。经服用本发明药物水煎服，每天一剂，分早晚两次服用，服用4个疗程后，患者症状减轻，经检查肿瘤缩小为1.5cm×1.3cm，病情好转。继续服用6个疗程，肝区经检查肿瘤小于0.7×0.8cm。继续服用6个疗程复查，肿瘤消失痊愈，随访半年无复发。
具体实施方式
实施例1：
本实施例的治疗早期肝癌的中药配方，由以下重量份数的中药原料配制而成：：柴胡4份、蒲公英2份、蚤休2份、紫花地丁4份、佛手6份、玫瑰花8份、香橼4份、大蓟8份、郁金10份、莪术6份、三棱6份、黄药子6份、琥珀6份、牡蛎6份、沙苑子8份、鳖甲3份、田基黄3份、垂盆草3份、天南星2份、青皮2份、熟地3份、天冬2份、阿胶2份、墨旱莲2份和青木香2份。
本发明的中药配方，按下述方法制备：
按上述重量份数取上述中药原料，琥珀、鳖甲和阿胶研末备用；将其他药材混合均匀，洗净，加水煎煮2次，每次加水量为药材重量的4倍，煎煮3h，合并煎液，并加入琥珀、鳖甲和阿胶粉末，得到本发明的治疗早期肝癌的中药汤剂。
用法：成人每次服用250mL，每日2次，饭后2小时温服，15天为一个疗程。

Claims (2)

1.一种治疗早期肝癌的中药配方，其特征在于由以下重量份数的中药配比而成：柴胡3-5份、蒲公英1-3份、蚤休2-4份、紫花地丁3-5份、佛手5-8份、玫瑰花5-8份、香橼3-5份、大蓟5-8份、郁金8-12份、莪术5-8份、三棱5-8份、黄药子5-8份、琥珀5-8份、牡蛎5-8份、沙苑子5-8份、鳖甲2-4份、田基黄2-4份、垂盆草2-4份、天南星1-3份、青皮1-3份、熟地2-4份、天冬1-3份、阿胶1-3份、墨旱莲1-3份和青木香1-3份。
2.根据权利要求1所述的治疗早期肝癌的中药配方，其特征在于由以下重量份数的中药配比而成：柴胡4份、蒲公英2份、蚤休2份、紫花地丁4份、佛手6份、玫瑰花8份、香橼4份、大蓟8份、郁金10份、莪术6份、三棱6份、黄药子6份、琥珀6份、牡蛎6份、沙苑子8份、鳖甲3份、田基黄3份、垂盆草3份、天南星2份、青皮2份、熟地3份、天冬2份、阿胶2份、墨旱莲2份和青木香2份。
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CN105327283A (zh) * 2015-12-01 2016-02-17 青岛市肿瘤医院 一种治疗早期肝癌的中药配方
CN105326994A (zh) * 2015-12-01 2016-02-17 青岛市肿瘤医院 一种治疗肝气郁结型早期肝癌的中药配方
CN105535898A (zh) * 2016-01-07 2016-05-04 青岛市肿瘤医院 一种治疗脾虚湿困型早期肝癌的中药配方
CN105582466A (zh) * 2015-12-31 2016-05-18 崔鹏 一种治疗肝癌早期的中药配方
CN110898192A (zh) * 2019-08-22 2020-03-24 文一兵 一种治疗肝癌的中药配方及其制备方法

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Publication number Priority date Publication date Assignee Title
CN105327283A (zh) * 2015-12-01 2016-02-17 青岛市肿瘤医院 一种治疗早期肝癌的中药配方
CN105326994A (zh) * 2015-12-01 2016-02-17 青岛市肿瘤医院 一种治疗肝气郁结型早期肝癌的中药配方
CN105582466A (zh) * 2015-12-31 2016-05-18 崔鹏 一种治疗肝癌早期的中药配方
CN105535898A (zh) * 2016-01-07 2016-05-04 青岛市肿瘤医院 一种治疗脾虚湿困型早期肝癌的中药配方
CN110898192A (zh) * 2019-08-22 2020-03-24 文一兵 一种治疗肝癌的中药配方及其制备方法

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