CN104491719A - 一种治疗宫颈癌的中药组合物 - Google Patents

一种治疗宫颈癌的中药组合物 Download PDF

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CN104491719A
CN104491719A CN201410779296.1A CN201410779296A CN104491719A CN 104491719 A CN104491719 A CN 104491719A CN 201410779296 A CN201410779296 A CN 201410779296A CN 104491719 A CN104491719 A CN 104491719A
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牟慧芳
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Abstract

本发明公开了一种治疗宫颈癌的中药组合物,属于中药技术领域,由下述原料制备而成:红花,茵陈,当归,枸杞子,鹿角,桃仁,赤芍,丹参,桂枝,肉桂,阳起石,黄连,土茯苓,山药,柴胡,枳壳,地骨皮,香附,郁金,玄参,牛膝,丹皮,连翘,蒲公英,知母,天南星,黄药子,斑蝥,猫爪草,夏枯草,蟅虫,莪术,三棱,人参,鹿茸,薏苡仁,桂圆,红豆。本发明将以上药物组合后,药效协同作用,具有补气养血、补益肝肾、消瘀生肌,并且有补中益气、补肺气、养胃津之功效,可调整人体阴阳平衡,排除癌毒素,祛邪扶正,很大程度的减少癌症患者的痛苦,无毒副,不易复发,真正做到治病固本。

Description

一种治疗宫颈癌的中药组合物
技术领域
本发明涉及一种治疗宫颈癌的中药组合物,属中药领域。
背景技术
宫颈癌是指子宫颈上皮细胞发生癌变,病穿透基底膜浸润间质组织,是全世界妇女最常见的恶性生殖道肿瘤。宫颈癌发病原因大多数和患者日常生活有关,比如病毒感染、性行为及分娩次数、其他生物学因素、其他行为因素都有可能会增加患病率。宫颈癌症状大多为阴道流血,早期多为接触性出血,中晚期为不规则阴道流血,经期延长、经量增多;绝经后不规则阴道流血,不同年龄阶段的患者,症状表现也会不同。宫颈癌症状除了阴道出血,多数患者会出现阴道排液(液体为白色或血性,可稀薄如水样或米泔状,或有腥臭)。晚期症状会出现不同的继发性症状。如尿频、尿急、便秘、下肢肿痛等。
宫颈癌的治疗主要是手术及放射治疗。尤其是鳞癌对放射治疗较敏感。近年来抗癌化学药物的迅猛发展,过去认为对宫颈癌无效的化疗,现已成为辅助治疗的常用方法,尤其在晚期或复发者。在手术或放疗前先用化疗,化疗后待癌灶萎缩或部分萎缩后再行手术或放疗,或者手术或化疗后再加用化疗,便可提高疗效。但是手术或者放疗对身体伤害很大或者有很大的毒副作用,会引起严重毒性反应;并且,身体情况较差或者年纪较大的患者不适于手术或者放疗。
发明内容
本发明的目的在于提供一种治疗宫颈癌的中药组合物,全部选用天然中草药,能够有效治疗宫颈癌。
本发明解决技术问题所采取的技术方案是:
一种治疗宫颈癌的中药组合物,其特征是,由以下重量的中药制成:
红花10-20克,茵陈10-15克,当归5-15克,枸杞5-15克,鹿角片5-15克,桃仁5-15克,赤芍5-15克,丹参5-15克,桂枝5-15克,肉桂5-15克,阳起石5-15克,黄连5-15克,土茯苓5-15克,山药15-25克,柴胡5-15克,枳壳5-15克,地骨皮5-15克,香附5-15克,郁金5-15克,玄参10-20克,牛膝5-15克,丹皮10-20克,连翘10-20克,蒲公英10-20克,知母10-20克,天南星5-15克,黄药子5-15克,斑蝥5-15克,猫爪草5-15克,夏枯草5-15克,蟅虫5-15克,莪术5-15克,三棱5-15克,人参10-20克,鹿茸10-20,薏苡仁10-20克,桂圆10-20克,红豆10-20克。
优选的,由以下重量的中药制成:
红花10克,茵陈10克,当归10克,枸杞子10克,鹿角10克,桃仁10克,赤芍10克,丹参10克,桂枝10克,肉桂10克,阳起石10克,黄连10克,土茯苓10克,山药10克,柴胡10克,枳壳10克,地骨皮10克,香附10克,郁金10克,玄参15克,牛膝10克丹皮15克,连翘15克,蒲公英15克,知母15克,天南星5克,黄药子5克,斑蝥5克,猫爪草5克,夏枯草5克,蟅虫5克,莪术5克,三棱5克,人参15克,鹿茸15克,薏苡仁15克,桂圆20克,红豆20克。
进一步的,由以下重量的中药制成:
红花15克,茵陈15克,当归10克,枸杞10克,鹿角片10克,桃仁10,克赤芍10克,丹参10克,桂枝10克,肉桂10克,阳起石10克,黄连10克,土茯苓10克,山药20克,柴胡10克,枳壳10克,地骨皮10克,香附10克,郁金10克,玄参15克,牛膝10克丹皮15克,连翘15克,蒲公英15克,知母15克,天南星10克,黄药子10克,斑蝥10克,猫爪草10克,夏枯草10克,蟅虫10克,莪术10克,三棱10克,人参15克,鹿茸15,薏苡仁15克,桂圆15克,红豆15克。
进一步的,由以下重量的中药制成:
红花20克,茵陈15克,当归15克,枸杞15克,鹿角片15克,桃仁15,克赤芍15克,丹参15克,桂枝15克肉桂15克,阳起石15克,黄连15克,土茯苓15克,山药25克,柴胡15克,枳壳15克,地骨皮15克,香附15克,郁金15克,玄参20克,牛膝15克,丹皮20克,连翘20克,蒲公英20克,知母20克,天南星15克,黄药子15克,斑蝥15克,猫爪草15克,夏枯草15克,蟅虫15克,莪术15克,三棱15克,人参20克,鹿茸20,薏苡仁20克,桂圆20克,红豆20克。
配制及服用方法:先将上述原料药用水浸泡2个半小时,砂锅大火煮20分钟,转文火煮15分钟,倒出药液;再加开水文火煮25分钟,倒出药液;两遍药液混一起,凉透,分别于早晚饭后半小时到一小时之内服用。连服15天为一疗程。
红花:辛,温。主治妇女病,通经、活血。
茵陈:性味归经:苦、辛,微寒;清热利湿,利胆,保护肝功能,解热,抗炎,降血脂。
当归:甘辛,温。入心、肝、脾经。补血和血,调经止痛,润燥滑肠。治月经不调,经闭腹痛,癥瘕结聚,崩漏;血虚头痛,眩晕,痿痹;肠燥便难,赤痢后重;痈疽疮窃,跌扑损伤。
枸杞子:甘,平。归肝、肾经。功能主治:滋补肝肾,益精明目。用于虚劳精亏,腰膝酸痛,眩晕耳鸣,内热消渴,血虚萎黄,目昏不明。
鹿角:性味咸,温。归肝、肾经。功能主治:温肾阳,强筋骨,行血消肿。用于阳痿遗精,腰脊冷痛,阴疽疮疡,乳痈初起,瘀血肿痛。
桃仁:苦甘,平。入心、肝、大肠经。破血行瘀,润燥滑肠。治经闭,癥瘕,热病蓄血,风痹,疟疾,跌打损伤,瘀血肿痛,血燥便秘。
赤芍:苦,微寒。归肝经。清热凉血,散瘀止痛。用于温毒发斑,吐血衄血,目赤肿痛,肝郁胁痛,经闭痛经,症瘕腹痛,跌扑损伤,痈肿疮疡。
丹参:苦,微寒。归心、肝经。用于祛瘀止痛,活血通经,清心除烦。用于月经不调,经闭痛经,症瘕积聚,胸腹刺痛,热痹疼痛,疮疡肿痛,心烦不眠;肝脾肿大,心绞痛。
桂枝:辛;甘;性温,归肺经,用于散寒解表;温通经脉;通阳化气。主风寒表证;寒湿痹痛;四肢厥冷;经闭痛经;症瘕结块;胸痹;心悸;痰饮;小便不利
肉桂:辛、甘,大热。归肾、脾、心、肝经。用于补火助阳,引火归源,散寒止痛,活血通经。用于阳痿,宫冷,腰膝冷痛,肾虚作喘,阳虚眩晕,目赤咽痛,心腹冷痛,虚寒吐泻,寒疝,奔豚,经闭,痛经。
阳起石:咸,温。入肾经。治下焦虚寒,腰膝冷痹,男子阳痿,女子宫冷,症瘕崩漏。
黄连:苦,寒。归心、脾、胃、肝、胆、大肠经。主治:清热燥湿,泻火解毒。用于湿热痞满,呕吐吞酸,泻痢,黄疸,高热神昏,心火亢盛,心烦不寐,血热吐衄,目赤,牙痛,消渴,痈肿疔疮;外治湿疹,湿疮,耳道流脓。酒黄连善清上焦火热。用于目赤,口疮。姜黄连清胃和胃止呕。用于寒热互结,湿热中阻,痞满呕吐。萸黄连舒肝和胃止呕。用于肝胃不和,呕吐吞酸。
土茯苓:甘、淡,平。归经:归肝、胃经。功能主治:除湿,解毒,通利关节。用于湿热淋浊,带下,痈肿,瘰疬,疥癣,梅毒及汞中毒所致的肢体拘挛,筋骨疼痛。
山药:甘,平。归脾、肺、肾经。功能主治:补脾养胃,生津益肺,补肾涩精。用于脾虚食少,久泻不止,肺虚喘咳,肾虚遗精,带下,尿频,虚热消渴。
柴胡:辛、微苦、微寒;归肝、胆经。解表退热,舒肝解郁,升举阳气。本品疏达善透,长于疏解肝胆郁热,又能疏肝理气,为治疗肝胆郁热、肝郁气滞所致胁肋疼痛要药。药理研究证实:柴胡有较强的解热、抗炎、抗菌、抗病毒、保肝、利胆、镇静、镇痛等作用。
枳壳:苦、辛、酸,温。归经:归脾、胃经。功能主治:理气宽中,行滞消胀。用于胸胁气滞,胀满疼痛,食积不化,痰饮内停;胃下垂,脱肛,子官脱垂。
地骨皮:甘,寒。归肺、肝、肾经。主治:凉血除蒸,清肺降火。用于阴虚潮热,骨蒸盗汗,肺热咳嗽,咯血,衄血,内热消渴。
香附:理气解郁,止痛调经。治肝胃不和,气郁不舒,胸腹胁肋胀痛,痰饮痞满,月经不调。
郁金:辛苦,凉。入心、肺、肝经。行气解郁,凉血破瘀,治胸腹胁肋诸痛,失心癫狂,热病神昏,吐血,黄疸。
玄参:甘、苦、咸,微寒。归肺、胃、肾经。功能主治:凉血滋阴,泻火解毒。用于热病伤阴,舌绛烦渴,温毒发斑,津伤便秘,骨蒸劳嗽,目赤,咽痛,瘰疠,白喉,痈肿疮毒。
牛膝:苦、酸,平。归肝、肾经。功能主治:补肝肾,强筋骨,逐瘀通经,引血下行。用于腰膝酸痛,筋骨无力,经闭症瘕,肝阳眩晕。
丹皮:清热,凉血,和血,消瘀。治热入血分,发斑,惊痫,吐、衄、便血,骨蒸劳热,经闭,癥瘕,痈疡,扑损。
连翘:苦,微寒。归经:归肺、心、小肠经。功能主治:清热解毒,消肿散结。用于痈疽,瘰疠,乳痈,丹毒,风热感冒,温病初起,温热入营,高热烦渴,神昏发斑,热淋尿闭。
蒲公英:苦、甘,寒。归肝、胃经。功能主治:清热解毒,消肿散结,利尿通淋。用于疔疮肿毒,乳痈,瘰疠,目赤,咽痛,肺痈,肠痈,湿热黄疸,热淋涩痛。
知母:苦、甘,寒。归经:归肺、胃、肾经。功能主治:清热泻火,生津润燥。用于外感热病,高热烦渴,肺热燥咳,骨蒸潮热,内热消渴,肠燥便秘。
天南星:性味苦、辛,温;有毒。归肺、肝、脾经。功能主治:燥湿化痰,祛风止痉,散结消肿。用于顽痰咳嗽,风痰眩晕,中风痰壅,口眼歪斜,半身不遂,癫痫,惊风,破伤风。生用外治痈肿,蛇虫咬伤。
黄药子:性味苦、辛,凉。有小毒。功能主治:解毒消肿,化痰散结,凉血止血。用于甲状腺肿大,淋巴结结核,咽喉肿痛,吐血,咯血,百日咳,癌肿;外用治疮疖。
斑蝥:性味辛,热;有大毒。归肝、胃、肾经。功能主治:破血消癓,功毒蚀疮,引赤发泡。用于癓瘕肿块,积年顽癣,瘰疬,赘疣,痈疽不溃,恶疮死肌。
猫爪草:性味甘、辛,温。归肝、肺经。功能主治:散结,消肿。用于瘰疬未溃、淋巴结结核。
夏枯草:性味辛、苦,寒。归肝、胆经。功能主治:清火,明目,散结,消肿。用于目赤肿痛,目珠夜痛,头痛眩晕,瘰疬,瘿瘤,乳痈肿痛;甲状腺肿大,淋巴结结核,乳腺增生,高血压。
蟅虫:咸,寒,有毒。入心、肝、脾三经。功能主治:逐瘀,破积,通络,理伤。治症瘕积聚,血滞经闭,产后瘀血腹痛,跌打损伤,木舌,重舌。
莪术:性味辛、苦,温。归肝、脾经。功能主治:行气破血,消积止痛。用于燀瘕痞块,瘀血经闭,食积胀痛;早期宫颈癌。
三棱:性味辛、苦,平。归肝、脾经。功能主治:破血行气,消积止痛。用于症瘕痞块,瘀血经闭,食积胀痛。
人参:味甘,微温,无毒。入脾、肺经。大补元气,固脱生津,安神。治劳伤虚损,食少,倦怠,反胃吐食,大便滑泄,虚咳喘促,自汗暴脱,惊悸,健忘,眩晕头痛,阳痿,尿频,消渴,妇女崩漏,小儿慢惊,及久虚不复,一切气血津液不足之证。
鹿茸:甘、咸,温。归肾、肝经。功能主治:壮肾阳,益精血,强筋骨,调冲任,托疮毒。用于阳痿滑精,宫冷不孕,羸瘦,神疲,畏寒,眩晕耳鸣耳聋,腰脊冷痛,筋骨痿软,崩漏带下,阴疽不敛。
薏苡仁:甘淡,凉。入脾、肺、肾经。健脾,补肺,清热,利湿。治泄泻,湿痹,筋脉拘挛,屈伸不利,水肿,脚气,肺痿,肺痈,肠痈,淋浊,白带。
桂圆:补心脾,益气血,健脾胃,养肌肉。思虑伤脾,头昏,失眠,心悸怔忡,虚赢,病后或产后体虚,及由于脾虚所致之下血失血症。
红豆:性平,味苦,有小毒。:理气,通经。治疝气,腹痛,血滞经闭,健脾止泻,利水消肿。
此中药配方治疗宫颈癌对患者身体的损害较小,可以有效治疗宫颈癌,防止复发和转移,且无毒副作用,中医在治疗中更注重顾全整体及患者的脏腑、气血、津液、经脉等诸多方面的平衡,起到治病求本的作用。
以下结合临床资料及典型病例对本发明的有益效果进一步说明。
一、临床观察
1、临床资料:选择宫颈癌患者130例,临床符合宫颈癌的诊断标准,年龄30-55岁,平均年龄42岁。
2、诊断标准:以我国卫生部编的《中国常见恶性肿瘤诊治规范》中的宫颈癌诊断标准为依据。临床分期均属Ⅱ期、Ⅲ期、Ⅳ期。符合《中国常见恶性肿瘤诊治规范》的标准及客观疗效评定标准,采用WHO标准进行评定。
3、治疗方法:服用本发明药物,水煎煮,分两次早晚服用。15天为1个疗程。
4、疗效评定标准:按照卫生部《中国常见恶性肿瘤诊治规范》宫颈癌疗效评定标准,以患者治疗前与治疗后B超或CT进行对照比较:
完全缓解(CR):所有病变完全消失并持续4周以上;
部分缓解(PR):肿瘤病灶最大垂直两径乘积缩小≥50%,并维持4周以上;
稳定(SD):肿瘤缩小或增大均未超过50%;
进展(PD):肿瘤病灶增大超过50%,或出现新病灶
5、治疗结果:完全缓解92例,部分缓解18例,稳定17例,进展3例。稳定率(CR+PR+SD)为97.5%。
6、讨论
综上所述,本发明用于治疗宫颈癌的药物,经临床试验证明此药物,可有效治疗宫颈癌,抑制宫颈癌发展,明显改善患者症状、体征,无明显毒副作用。
二、典型病例
病例1:张某某,女,32岁。患者近两年来有同房后出血,没有去就诊。半个月以来有不明原因的阴道流液,伴有异味。到当地医院就诊,妇科检查发现宫颈有菜花样肿物,并有接触性出血,活检病理提示宫颈中分化鳞癌。经服用本发明治疗宫颈癌的中药是三个疗程后,阴道流液基本消失,宫颈菜花状肿物有明显减小,继续服用三个疗程,症状基本消失,身体恢复正常,体质也有所改善。
病例2:徐某某,50岁。患者2005年确诊为宫颈高分化腺癌,放疗治疗后病情反复,经服用次发明中药2个疗程,阴道流血、下腹坠痛有所改善,继续服用2个疗程,阴道流血、下腹坠痛症状有明显改善,再次服用2个疗程,症状已经完全消失,恢复正常,睡眠以及消化系统都得到很大的改善,皮肤也红润很多。随访一年无复发。
病例3:孙某,患者平素月经规则,5月前无明显诱因下出现经间期阴道不规则流血,量少,色较暗,无血块,未见肉样组织经阴道流出,持续至今,白带量较多,色黄,偶有臭味,畏寒,发热,头晕,乏力,腹痛,腹胀,外阴瘙痒脓,尿频、尿急、尿痛。服用此发明中药两个疗程,白带减少,异味消失,头晕乏力,腹痛症状也有所减轻,外阴瘙痒症状消失,继续服用两个疗程,上述情况基本消失,无畏寒现象,最后巩固两个疗程,已经完全康复,体质得到改善,精力充沛了许多。随访1年无复发。
具体实施方式
实施例1:
一种治疗宫颈癌的中药组合物,由以下重量的中药制成:
红花10克,茵陈10克,当归10克,枸杞10克,鹿角10克,桃仁10克,赤芍10克,丹参10克,桂枝10克,肉桂10克,阳起石10克,黄连10克,土茯苓10克,山药10克,柴胡10克,枳壳10克,地骨皮10克,香附10克,郁金10克,玄参15克,牛膝10克,丹皮15克,连翘15克,蒲公英15克,知母15克,天南星5克,黄药子5克,斑蝥5克,猫爪草5克,夏枯草5克,蟅虫5克,莪术5克,三棱5克,人参15克,鹿茸15克,薏苡仁15克,桂圆20克,红豆20克。
配制及服用方法:先将上述原料药用水浸泡2个半小时,砂锅大火煮20分钟,转文火煮15分钟,倒出药液;再加开水文火煮25分钟,倒出药液;两遍药液混一起,凉透,分别于早晚饭后半小时到一小时之内服用。连服15天为一疗程。
实施例2:
一种治疗宫颈癌的中药组合物,由下述重量的原料药制成:
红花15克,茵陈15克,当归10克,枸杞10克,鹿角片10克,桃仁10,克赤芍10克,丹参10克,桂枝10克,肉桂10克,阳起石10克,黄连10克,土茯苓10克,山药20克,柴胡10克,枳壳10克,地骨皮10克,香附10克,郁金10克,玄参15克,牛膝10克丹皮15克,连翘15克,蒲公英15克,知母15克,天南星10克,黄药子10克,斑蝥10克,猫爪草10克,夏枯草10克,蟅虫10克,莪术10克,三棱10克,人参15克,鹿茸15,薏苡仁15克,桂圆15克,红豆15克。
配制及服用方法:同例1。
实施例3:
一种治疗宫颈癌的中药组合物,由下述重量的原料药制成:
红花20克,茵陈15克,当归15克,枸杞15克,鹿角片15克,桃仁15克,赤芍15克,丹参15克,桂枝15克肉桂15克,阳起石15克,黄连15克,土茯苓15克,山药25克,柴胡15克,枳壳15克,地骨皮15克,香附15克,郁金15克,玄参20克,牛膝15克,丹皮20克,连翘20克,蒲公英20克,知母20克,天南星15克,黄药子15克,斑蝥15克,猫爪草15克,夏枯草15克,蟅虫15克,莪术15克,三棱15克,人参20克,鹿茸20,薏苡仁20克,桂圆20克,红豆20克。
配制及服用方法:同例1。

Claims (4)

1.一种治疗宫颈癌的中药组合物,其特征是,由以下重量的中药制成:
红花10-20克,茵陈10-15克,当归5-15克,枸杞5-15克,鹿角片5-15克,桃仁5-15克,赤芍5-15克,丹参5-15克,桂枝5-15克,肉桂5-15克,阳起石5-15克,黄连5-15克,土茯苓5-15克,山药15-25克,柴胡5-15克,枳壳5-15克,地骨皮5-15克,香附5-15克,郁金5-15克,玄参10-20克,牛膝5-15克,丹皮10-20克,连翘10-20克,蒲公英10-20克,知母10-20克,天南星5-15克,黄药子5-15克,斑蝥5-15克,猫爪草5-15克,夏枯草5-15克,庶虫5-15克,莪术5-15克,三棱5-15克,人参10-20克,鹿茸10-20,薏苡仁10-20克,桂圆10-20克,红豆10-20克。
2.根据权利要求1所述的治疗宫颈癌的中药组合物,其特征是,由以下重量的中药制成:
红花10克,茵陈10克,当归10克,枸杞10克,鹿角10克,桃仁10克,赤芍10克,丹参10克,桂枝10克,肉桂10克,阳起石10克,黄连10克,土茯苓10克,山药10克,柴胡10克,枳壳10克,地骨皮10克,香附10克,郁金10克,玄参15克,牛膝10克,丹皮15克,连翘15克,蒲公英15克,知母15克,天南星5克,黄药子5克,斑蝥5克,猫爪草5克,夏枯草5克,庶虫5克,莪术5克,三棱5克,人参15克,鹿茸15克,薏苡仁15克,桂圆20克,红豆20克。
3.根据权利要求1所述的治疗宫颈癌的中药组合物,其特征是,由以下重量的中药制成:
红花15克,茵陈15克,当归10克,枸杞10克,鹿角片10克,桃仁10,克赤芍10克,丹参10克,桂枝10克,肉桂10克,阳起石10克,黄连10克,土茯苓10克,山药20克,柴胡10克,枳壳10克,地骨皮10克,香附10克,郁金10克,玄参15克,牛膝10克丹皮15克,连翘15克,蒲公英15克,知母15克,天南星10克,黄药子10克,斑蝥10克,猫爪草10克,夏枯草10克,庶虫10克,莪术10克,三棱10克,人参15克,鹿茸15,薏苡仁15克,桂圆15克,红豆15克。
4.根据权利要求1所述的治疗宫颈癌的中药组合物,其特征是,由以下重量的中药制成:
红花20克,茵陈15克,当归15克,枸杞15克,鹿角片15克,桃仁15克,赤芍15克,丹参15克,桂枝15克肉桂15克,阳起石15克,黄连15克,土茯苓15克,山药25克,柴胡15克,枳壳15克,地骨皮15克,香附15克,郁金15克,玄参20克,牛膝15克,丹皮20克,连翘20克,蒲公英20克,知母20克,天南星15克,黄药子15克,斑蝥15克,猫爪草15克,夏枯草15克,庶虫15克,莪术15克,三棱15克,人参20克,鹿茸20,薏苡仁20克,桂圆20克,红豆20克。
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