CN104490893B - 一种治疗失眠的药物组合物 - Google Patents
一种治疗失眠的药物组合物 Download PDFInfo
- Publication number
- CN104490893B CN104490893B CN201410722860.6A CN201410722860A CN104490893B CN 104490893 B CN104490893 B CN 104490893B CN 201410722860 A CN201410722860 A CN 201410722860A CN 104490893 B CN104490893 B CN 104490893B
- Authority
- CN
- China
- Prior art keywords
- insomnia
- cure
- pharmaceutical composition
- compound
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 title claims abstract description 14
- 206010022437 insomnia Diseases 0.000 title claims abstract description 13
- 239000008194 pharmaceutical composition Substances 0.000 title abstract description 10
- 150000001875 compounds Chemical class 0.000 claims abstract description 20
- 239000003814 drug Substances 0.000 claims description 6
- 239000003937 drug carrier Substances 0.000 abstract description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 239000003085 diluting agent Substances 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 2
- 230000002421 anti-septic effect Effects 0.000 description 2
- -1 antiseptic Substances 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N lactose group Chemical group OC1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](O2)CO)[C@H](O1)CO GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 239000013641 positive control Substances 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 206010019233 Headaches Diseases 0.000 description 1
- 206010020852 Hypertonia Diseases 0.000 description 1
- 206010024642 Listless Diseases 0.000 description 1
- 229920000881 Modified starch Polymers 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- QGMRQYFBGABWDR-UHFFFAOYSA-M Pentobarbital sodium Chemical compound [Na+].CCCC(C)C1(CC)C(=O)NC(=O)[N-]C1=O QGMRQYFBGABWDR-UHFFFAOYSA-M 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000012050 conventional carrier Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 206010016256 fatigue Diseases 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000007951 isotonicity adjuster Substances 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 235000020094 liqueur Nutrition 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 239000004531 microgranule Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 229960002275 pentobarbital sodium Drugs 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 201000000980 schizophrenia Diseases 0.000 description 1
- 208000019116 sleep disease Diseases 0.000 description 1
- 230000004622 sleep time Effects 0.000 description 1
- 208000020685 sleep-wake disease Diseases 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000002557 soporific effect Effects 0.000 description 1
- 235000020354 squash Nutrition 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410722860.6A CN104490893B (zh) | 2014-12-02 | 2014-12-02 | 一种治疗失眠的药物组合物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410722860.6A CN104490893B (zh) | 2014-12-02 | 2014-12-02 | 一种治疗失眠的药物组合物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104490893A CN104490893A (zh) | 2015-04-08 |
CN104490893B true CN104490893B (zh) | 2016-01-06 |
Family
ID=52932408
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410722860.6A Active CN104490893B (zh) | 2014-12-02 | 2014-12-02 | 一种治疗失眠的药物组合物 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN104490893B (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105218465A (zh) * | 2015-11-14 | 2016-01-06 | 刘杰 | 一种治疗乳腺癌的药物组合物 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1546037A (zh) * | 2003-12-08 | 2004-11-17 | 南昌弘益科技有限公司 | 地西泮滴丸及其制备方法 |
US20080279784A1 (en) * | 2007-05-07 | 2008-11-13 | Questcor Pharmaceuticals, Inc. | Nasal administration of benzodiazepines |
-
2014
- 2014-12-02 CN CN201410722860.6A patent/CN104490893B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1546037A (zh) * | 2003-12-08 | 2004-11-17 | 南昌弘益科技有限公司 | 地西泮滴丸及其制备方法 |
US20080279784A1 (en) * | 2007-05-07 | 2008-11-13 | Questcor Pharmaceuticals, Inc. | Nasal administration of benzodiazepines |
Also Published As
Publication number | Publication date |
---|---|
CN104490893A (zh) | 2015-04-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C41 | Transfer of patent application or patent right or utility model | ||
CB03 | Change of inventor or designer information |
Inventor after: Zhang Yan Inventor before: Li Zhigang |
|
COR | Change of bibliographic data | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20151204 Address after: 226600 Haian, Nantong, Haian economic and Technological Development Zone, West Beihai Road, No. 4, No. Applicant after: LI FUJUN Address before: 050051 No. 118, cooperation Road, Shijiazhuang, Hebei Applicant before: Li Zhigang |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20200420 Address after: Room 1018, building 2, No. 85, Sandun Road, Xiangfu street, Gongshu District, Hangzhou City, Zhejiang Province Patentee after: HANGZHOU MEIYA PHARMACY Co.,Ltd. Address before: 226600, No. 4 West Beihai Road, Haian economic and Technological Development Zone, Haian County, Jiangsu, Nantong Patentee before: MEIYA PHARMACEUTICAL HAIAN Co.,Ltd. |
|
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20200702 Address after: 226600 No.40, Kanghua Road, Chengdong Town, Hai'an County, Nantong City, Jiangsu Province Patentee after: MEIYA PHARMACEUTICAL HAIAN Co.,Ltd. Address before: Room 1018, building 2, No. 85, Sandun Road, Xiangfu street, Gongshu District, Hangzhou City, Zhejiang Province Patentee before: HANGZHOU MEIYA PHARMACY Co.,Ltd. |