CN104490855A - Dental chemical removal compound formula for root-canal filling of gutta pertscha - Google Patents
Dental chemical removal compound formula for root-canal filling of gutta pertscha Download PDFInfo
- Publication number
- CN104490855A CN104490855A CN201410782991.3A CN201410782991A CN104490855A CN 104490855 A CN104490855 A CN 104490855A CN 201410782991 A CN201410782991 A CN 201410782991A CN 104490855 A CN104490855 A CN 104490855A
- Authority
- CN
- China
- Prior art keywords
- gutta
- solution
- limonene
- root
- obtains
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004262 dental pulp cavity Anatomy 0.000 title claims abstract description 26
- 239000000126 substance Substances 0.000 title claims abstract description 14
- 238000011049 filling Methods 0.000 title claims abstract description 11
- 150000001875 compounds Chemical class 0.000 title abstract 4
- XMGQYMWWDOXHJM-JTQLQIEISA-N (+)-α-limonene Chemical compound CC(=C)[C@@H]1CCC(C)=CC1 XMGQYMWWDOXHJM-JTQLQIEISA-N 0.000 claims abstract description 32
- 230000001804 emulsifying effect Effects 0.000 claims abstract description 9
- 239000007788 liquid Substances 0.000 claims abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 8
- BEGBSFPALGFMJI-UHFFFAOYSA-N ethene;sodium Chemical group [Na].C=C BEGBSFPALGFMJI-UHFFFAOYSA-N 0.000 claims abstract description 5
- IYFATESGLOUGBX-YVNJGZBMSA-N Sorbitan monopalmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O IYFATESGLOUGBX-YVNJGZBMSA-N 0.000 claims abstract description 4
- -1 sorbitan aliphatic ester Chemical class 0.000 claims abstract description 4
- 239000000899 Gutta-Percha Substances 0.000 claims description 32
- 229920000588 gutta-percha Polymers 0.000 claims description 32
- 240000000342 Palaquium gutta Species 0.000 claims description 31
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
- 239000012153 distilled water Substances 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 5
- 239000002131 composite material Substances 0.000 claims description 4
- 238000009472 formulation Methods 0.000 claims description 4
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 3
- MORMPWNLQJTSOT-UHFFFAOYSA-L disodium;4-dodecyl-2-(4-sulfonatophenoxy)benzenesulfonate Chemical compound [Na+].[Na+].CCCCCCCCCCCCC1=CC=C(S([O-])(=O)=O)C(OC=2C=CC(=CC=2)S([O-])(=O)=O)=C1 MORMPWNLQJTSOT-UHFFFAOYSA-L 0.000 claims description 3
- 210000002969 egg yolk Anatomy 0.000 claims description 3
- 239000000194 fatty acid Substances 0.000 claims description 3
- 229930195729 fatty acid Natural products 0.000 claims description 3
- 238000011017 operating method Methods 0.000 claims description 3
- 238000001556 precipitation Methods 0.000 claims description 3
- 238000000746 purification Methods 0.000 claims description 3
- JHJUUEHSAZXEEO-UHFFFAOYSA-M sodium;4-dodecylbenzenesulfonate Chemical compound [Na+].CCCCCCCCCCCCC1=CC=C(S([O-])(=O)=O)C=C1 JHJUUEHSAZXEEO-UHFFFAOYSA-M 0.000 claims description 3
- 239000006185 dispersion Substances 0.000 claims description 2
- 239000012456 homogeneous solution Substances 0.000 claims 1
- 238000010008 shearing Methods 0.000 claims 1
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract description 10
- 238000000034 method Methods 0.000 abstract description 10
- 239000000839 emulsion Substances 0.000 abstract description 4
- 238000002360 preparation method Methods 0.000 abstract description 4
- 239000008346 aqueous phase Substances 0.000 abstract 2
- WBJQYNGHUCFXMA-QNPXGKNTSA-N (1R,6R,12S,15S,18S,21S,24S,27S,30S,33S,36S,39S,42R,47R,50S,53S,56S,59S,62S,65S,68S,71S,74R,80S,83S,88R)-6-[[(2S)-2-[[(2S)-6-amino-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-amino-4-carboxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]-4-oxobutanoyl]amino]-3-carboxypropanoyl]amino]-3-phenylpropanoyl]amino]-3-methylpentanoyl]amino]hexanoyl]amino]propanoyl]amino]-88-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-amino-5-carbamimidamidopentanoyl]amino]-4-methylsulfanylbutanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-4-carboxybutanoyl]amino]hexanoyl]amino]-65-(4-aminobutyl)-39,59,71-tris[(2S)-butan-2-yl]-12,24,53,68-tetrakis(3-carbamimidamidopropyl)-15,36,83-tris(2-carboxyethyl)-42-[[2-[[(2S)-1-[[(2S)-1-[[(1S)-1-carboxy-2-hydroxyethyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]carbamoyl]-62-(carboxymethyl)-30-(1H-indol-3-ylmethyl)-56-methyl-18,27,50-tris(2-methylpropyl)-7,10,13,16,19,22,25,28,31,34,37,40,49,52,55,58,61,64,67,70,73,76,79,82,85,87-hexacosaoxo-21,33,80-tri(propan-2-yl)-3,4,44,45,90,91-hexathia-8,11,14,17,20,23,26,29,32,35,38,41,48,51,54,57,60,63,66,69,72,75,78,81,84,86-hexacosazabicyclo[72.11.7]dononacontane-47-carboxylic acid Chemical compound CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](N)CCC(O)=O)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC2=O)C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC1=O)C(C)C)C(C)C)[C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CO)C(O)=O)C(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CCCNC(N)=N)[C@@H](C)O WBJQYNGHUCFXMA-QNPXGKNTSA-N 0.000 abstract 1
- LGNQGTFARHLQFB-UHFFFAOYSA-N 1-dodecyl-2-phenoxybenzene Chemical compound CCCCCCCCCCCCC1=CC=CC=C1OC1=CC=CC=C1 LGNQGTFARHLQFB-UHFFFAOYSA-N 0.000 abstract 1
- 230000007012 clinical effect Effects 0.000 abstract 1
- 239000008367 deionised water Substances 0.000 abstract 1
- 229910021641 deionized water Inorganic materials 0.000 abstract 1
- GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 abstract 1
- 239000012071 phase Substances 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 21
- 238000005516 engineering process Methods 0.000 description 6
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 5
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 229940087305 limonene Drugs 0.000 description 4
- 230000001988 toxicity Effects 0.000 description 4
- 231100000419 toxicity Toxicity 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 235000001510 limonene Nutrition 0.000 description 3
- 230000002101 lytic effect Effects 0.000 description 3
- 241001074085 Scophthalmus aquosus Species 0.000 description 2
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 239000011787 zinc oxide Substances 0.000 description 2
- GRWRWBPVDAEEOO-UHFFFAOYSA-N 1-methyl-1-prop-1-en-2-ylcyclohexane Chemical compound CC(=C)C1(C)CCCCC1 GRWRWBPVDAEEOO-UHFFFAOYSA-N 0.000 description 1
- 241000207199 Citrus Species 0.000 description 1
- 244000248349 Citrus limon Species 0.000 description 1
- 235000005979 Citrus limon Nutrition 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 240000001624 Espostoa lanata Species 0.000 description 1
- 235000009161 Espostoa lanata Nutrition 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- CYTYCFOTNPOANT-UHFFFAOYSA-N Perchloroethylene Chemical group ClC(Cl)=C(Cl)Cl CYTYCFOTNPOANT-UHFFFAOYSA-N 0.000 description 1
- 201000004328 Pulpitis Diseases 0.000 description 1
- 241001093501 Rutaceae Species 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- RSWGJHLUYNHPMX-ONCXSQPRSA-N abietic acid Chemical compound C([C@@H]12)CC(C(C)C)=CC1=CC[C@@H]1[C@]2(C)CCC[C@@]1(C)C(O)=O RSWGJHLUYNHPMX-ONCXSQPRSA-N 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 239000003519 biomedical and dental material Substances 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 231100000315 carcinogenic Toxicity 0.000 description 1
- 239000013522 chelant Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 235000020971 citrus fruits Nutrition 0.000 description 1
- 239000001071 citrus reticulata blanco var. mandarin Substances 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 238000010297 mechanical methods and process Methods 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000002631 root canal filling material Substances 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 229950011008 tetrachloroethylene Drugs 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
- A61K31/015—Hydrocarbons carbocyclic
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dental Preparations (AREA)
- Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)
Abstract
The invention relates to a dental chemical removal compound formula for root-canal filling of gutta pertscha and a preparation technique. The preparation technique is characterized by comprising the following steps: (1) dissolving 2.572g of sorbitan aliphatic ester (Span40) and 70mg of protein lututrin in 70mL of D-limonene to obtain a D-limonene oily matter; (2) dissolving 3.36g of sodium ethylene diamine tetracetate (EDTA), 2.556g of dodecyl diphenyl ether sodium disulfonate and 2.092g of sodium dodecyl benzene sulfonate in deionized water (pH=8) to obtain an EDTA aqueous phase compound; and (3) slowly dropwise adding the aqueous phase liquid obtained in the step (2) into the oil phase liquid obtained in the step (1), simultaneously emulsifying by using an ultrasonic or high-shear force emulsifying machine, centrifugalizing an emulsion and abandoning precipitate to obtain the required emulsion compound. The clinical effect of the product obtained by the invention is similar to that of removing root-canal gutta pertscha by clinically using chloroform but has the biosafety which is uncomparable with chloroform.
Description
Technical field
The invention belongs to biomedical material technology, for needing a kind of chemical complex preparation technique removed by the gutta-percha class charges in primitive root pipe in clinical oral root canal.
Background technology
Root canal is the most effective Therapeutic Method thoroughly solving the diseases such as the irreversible inflammation of dental pulp, necrosis in current clinical oral.Along with the development of standardization root canal treatments, root canal is popularized at China's situation of all-level hospitals.Along with the increase of root canal tooth numbers, and the requirement of restoration of tooth technology to root canal therapy quality improves constantly, and increases gradually the case of again treating of former imperfection root canal.And the charges removed in former root canal be clinical in the most time-consuming, the most difficult, be also one of key link the most easily occurring again complication.
Gutta percha point and injection Warm gutta percha are be root canal filling material the most frequently used at present.It mainly contains the compositions such as gutta-percha (10-20%), zinc oxide (61-75%), Colophonium (1-4%), barium sulfate (10%).Gutta-percha is the support that its structure maintains, and when temperature reaches 56-64 DEG C, it becomes molten state.Therefore, current clinical employing local heat is the mechanical method removed also, but during operating cost and the easy root pipe side that occurs is worn.Adopt chemical method, Gutta percha material being dissolved is current most popular method.Chloroform is clinical gutta-percha solvent the most conventional, but chloroform is carcinogenic, hypertoxic, has potential threat and controversial to patient and doctor.Commercial " Dinke is removed " principle active component is tetrachloroethylene, although its toxicity is lower than chloroform, but still stronger.Gear division medicine society of Japan system reports a kind of gutta-percha solvent mixed by the volumetric ratio of 7:3 with D-limonene and normal hexane.Normal hexane has volatility, also has certain toxicity.Be used alone limonene relatively poor to the dissolubility of gutta-percha.
D-limonene [d-l monomethyl 1 (1 monomethyl vinyl) cyclohexane extraction)] be mainly derived from rutaceae, as Citrus, Fructus Citri Limoniae class peel, be a kind of plant base environmental protection organic solvent, there is good biological safety.Within 1994, limonene is by U.S.'s flavorant and extract AEM (Flavor and Extract Manufacture's Association of the United States, FEMA) assert that its toxicity belongs to GRAS (It is generally accepted safety) level, and edible through FDA approval.FAO(Food and Agriculture Organization of the United Nations) and WHO to D-twist lemon alkene use do not do particular provisions, therefore it is used widely in edible essence.Recently large quantity research finds that limonene has effect of good prevention and prohibition tumor promotion.Therefore, the safety gutta-percha lytic agent developed based on D mono-limonene has important clinical significance and application prospect.
Summary of the invention
There is carcinogenecity, toxicity problem in the root-canal filling gutta-percha chemolysis agent used for current clinical oral, the invention provides a kind of formula and the manufacture method with the root-canal filling gutta-percha lytic agent of biological safety.
The present invention is using D-limonene as gutta-percha main component---gutta-percha lytic agent, main inorganic composition---the zinc oxide of sodium ethylene diamine tetracetate (EDTA) chelant ties gutta-percha, form two aspects from Organic substance and inorganic matter, rapid damage gutta-percha structure, makes it collapse.In addition,---D-limonene and water miscible chelating agen---EDTA compound that employing emulsifying technology makes the mandarin oil of oiliness, makes stable emulsion dosage form.
concrete technical solution
Same claims.
advantageous Effects of the present invention is embodied in the following aspects
1, preparation method of the present invention is simple to operate, and controlling is good, and output is high, production environment close friend (room temperature condition, pollution-free).
2,the gutta-percha that the present invention obtains dissolves complex and has good biological safety.The safety FDA of main component D-limonene approves, the emulsifying agent that EDTA has used the present invention to use on clinical oral uses emulsified food is industrial, has comparatively safe performance.Therefore the reagent safety and reliability that ratio uses at present clinically in safety, is easily accepted by patient and dentist.
3,the new material Clinical practice that the present invention obtains is convenient, can at once use, and also can be enclosed in root pipe and in pulp cavity and use, safe and reliable.
Accompanying drawing explanation
fig. 1display obtain milky white stable with the chemical solution of D-limonene, the EDTA gutta-percha root-canal filling thing that is main component except complex.
fig. 2show chemical solution of the present invention except complex is to the solute effect of gutta-percha.Left figure is that gutta-percha has just inserted chemical solution of the present invention except in complex emulsion, and after right figure is presented at and inserts 5 min, the instant solution of gutta-percha is collapsed.
below by embodiment, the invention will be further described.
embodiment 1
1, the chemical solution of dental gutta-percha root-canal filling thing is except composite formulations and a manufacturing technology,comprise following operating procedure:
A: get commercially available D-limonene is 1.2 × 10Pa in vacuum, and under about 60 DEG C of conditions, distilling under reduced pressure, obtains the D-limonene (Rotary Evaporators, RE-52A, Shanghai Zhen Jie experimental facilities company limited) for subsequent use that purity is greater than 95%;
B: get purification D-limonene 70 mL that step A obtains, adds the proteineus yolk element of 70mg, makes it dissolve completely;
C: take 2.572 g sorbitan fatty acid esters (Span40), be dissolved in step B solution;
D: take 3.36 g sodium ethylene diamine tetracetates (EDTA), being dissolved in the distilled water of 20mL, is about 8 by sodium hydroxide adjust ph, obtains the EDTA solution of 0.5 M;
E: take 2.556g disodium 4-dodecyl-2,4 '-oxydibenzenesulfonate, 2.092 g dodecylbenzene sodium sulfonate are dissolved in the distilled water of 10 mL;
F: the solution that E step obtains is added in the solution of D step acquisition, make it be uniformly dispersed;
G: F step is obtained solution with the speed of 30 drops/sec, in the solution that instillation step C obtains, emulsifying in ultrasonic grinder, condition is as follows: 20-25KHz automatic frequency tracking, 950W(30%), random-amplitude bar (Φ 6), ultrasound works pattern: 5 s that work stop 1 s, be added dropwise to complete rear continuation ultrasonic emulsification 5 min.(ultrasonic grinder, SCIENTZ-
d, NingBo XinZhi Biology Science Co., Ltd);
F: mixed liquor centrifugal 5 min. under the condition of 10000 revs/min that G step obtains are abandoned precipitation, obtains milky white liquid;
H: preserve in the liquid seal that F step is obtained, lucifuge, room temperature, dry environment.
the chemical solution of dental gutta-percha root-canal filling thing of the present invention is except complex using method.
Method one: first use the mechanical apparatus such as P brill to remove root canal orifice part gutta percha point, use syringe that product of the present invention is injected several in root canal orifice, use root canal file to coordinate simultaneously, find that gutta-percha softens, structural deterioration, conveniently can remove the gutta-percha charges in root pipe;
Method two: first use the mechanical apparatus such as P brill to remove root canal orifice part gutta percha point, use syringe that product of the present invention is injected several in root canal orifice, insert the cotton balls containing this product at pulp chamber intracavity simultaneously, further consultation after the temporary envelope nest hole a few days, can find that the gutta-percha in root pipe softens, very convenient removal.
embodiment 2
The chemical solution of dental gutta-percha root-canal filling thing, except composite formulations and a manufacturing technology, comprises following operating procedure:
A: get commercially available D-limonene is 1.2 × 10Pa in vacuum, and under about 60 DEG C of conditions, distilling under reduced pressure, obtains the D-limonene (Rotary Evaporators, RE-52A, Shanghai Zhen Jie experimental facilities company limited) for subsequent use that purity is greater than 95%;
B: get purification D-limonene 70 mL that step A obtains, adds the proteineus yolk element of 70mg, makes it dissolve completely;
C: get 2.572 g sorbitan fatty acid esters (Span40), be dissolved in step B solution;
D: taking 3.36g sodium ethylene diamine tetracetate (EDTA), be dissolved in the distilled water of 20mL, is about 8 by sodium hydroxide adjust ph, obtains the EDTA solution of 0.5 M;
E: take 2.556g disodium 4-dodecyl-2,4 '-oxydibenzenesulfonate 2.092g dodecylbenzene sodium sulfonate and be dissolved in the distilled water of 10 mL;
F: the solution that E step obtains is added in the solution of D step acquisition, make it be uniformly dispersed;
G: F step is obtained solution with the speed of 30 drops/sec, in the solution that instillation step C obtains, at high shear force dispersion emulsifying machine, rustless steel working head, rotating speed 10000r/mim, under room temperature condition, carries out emulsifying, is added dropwise to complete rear continuation emulsifying 20 min;
F: mixed liquor centrifugal 5 min under the condition of 10000 revs/min that G step is obtained, abandon precipitation, obtain milky white liquid;
H: preserve in the liquid seal that F step is obtained, lucifuge, room temperature, dry environment.
using method: with example 1.
Claims (1)
1. the chemical solution of dental gutta-percha root-canal filling thing is except a composite formulations, it is characterized in that comprising following operating procedure:
A: get commercially available D-limonene is 1.2 × 10 Pa in vacuum, under about 60 DEG C of conditions, distilling under reduced pressure, obtain purity be greater than 95% D-limonene for subsequent use;
B: get purification D-limonene 70 mL that step A obtains, adds the proteineus yolk element of 70mg, makes it dissolve completely;
C: take 2.572 g sorbitan fatty acid esters (Span40), be scattered in step B solution, obtains homogeneous solution;
D: taking 3.36g sodium ethylene diamine tetracetate (EDTA), be dissolved in the distilled water of 20mL, is about 8 by sodium hydroxide adjust ph, obtains the EDTA solution of 0.5 M;
E: take 2.556g disodium 4-dodecyl-2,4 '-oxydibenzenesulfonate, 2.092g dodecylbenzene sodium sulfonate is dissolved in the distilled water of 10 mL;
F: the solution that E step obtains is added in the solution of D step acquisition, make it be uniformly dispersed;
G: F step is obtained solution with the speed of 30 drops/sec, in the solution that instillation step C obtains, emulsifying in ultrasonic grinder, or emulsified in high-shearing dispersion emulsifying machine condition;
F: mixed liquor centrifugal 5 min under the condition of 10000 revs/min that G step is obtained, abandon precipitation, obtain milky white liquid, be the chemical solution of gutta-percha root-canal filling thing except complex;
H: preserve in the liquid seal that F step is obtained, lucifuge, room temperature, dry environment.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410782991.3A CN104490855B (en) | 2014-12-18 | 2014-12-18 | Dental chemical removal compound preparation method for root-canal filling of gutta pertscha |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410782991.3A CN104490855B (en) | 2014-12-18 | 2014-12-18 | Dental chemical removal compound preparation method for root-canal filling of gutta pertscha |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104490855A true CN104490855A (en) | 2015-04-08 |
| CN104490855B CN104490855B (en) | 2017-01-18 |
Family
ID=52932372
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410782991.3A Active CN104490855B (en) | 2014-12-18 | 2014-12-18 | Dental chemical removal compound preparation method for root-canal filling of gutta pertscha |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104490855B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110314100A (en) * | 2019-07-11 | 2019-10-11 | 朗力生物医药(武汉)有限公司 | It is a kind of for it is molten except in root canal cloves phenols charges remove Dinke composite formulations |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1087521A (en) * | 1993-06-12 | 1994-06-08 | 宁存德 | Multipurpose inner coating agent for tooth |
| JPH09169612A (en) * | 1995-12-20 | 1997-06-30 | Nippon Shika Yakuhin Kk | Dental root canal filler composition |
| CN103520004A (en) * | 2012-07-05 | 2014-01-22 | 宁存德 | Shellac root canal filling agent |
| JP5439642B2 (en) * | 2009-08-07 | 2014-03-12 | 学校法人東日本学園 | Bactericidal root canal sealer and preparation kit |
-
2014
- 2014-12-18 CN CN201410782991.3A patent/CN104490855B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1087521A (en) * | 1993-06-12 | 1994-06-08 | 宁存德 | Multipurpose inner coating agent for tooth |
| JPH09169612A (en) * | 1995-12-20 | 1997-06-30 | Nippon Shika Yakuhin Kk | Dental root canal filler composition |
| JP5439642B2 (en) * | 2009-08-07 | 2014-03-12 | 学校法人東日本学園 | Bactericidal root canal sealer and preparation kit |
| CN103520004A (en) * | 2012-07-05 | 2014-01-22 | 宁存德 | Shellac root canal filling agent |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110314100A (en) * | 2019-07-11 | 2019-10-11 | 朗力生物医药(武汉)有限公司 | It is a kind of for it is molten except in root canal cloves phenols charges remove Dinke composite formulations |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104490855B (en) | 2017-01-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017500374A5 (en) | ||
| CN104434620A (en) | Acne-removing composition and preparation method thereof | |
| CN114796038A (en) | Composition for rapidly removing acne, sterilizing and removing mites as well as preparation method and application thereof | |
| CN102274174B (en) | Oil suspension agent of benzimidazole medicine | |
| US2115492A (en) | Pharmaceutical products adapted for injection into the human body | |
| TW201416071A (en) | Antiseptic, antiseborrheic and exfoliating composition to remove or prevent acne | |
| CN104490855A (en) | Dental chemical removal compound formula for root-canal filling of gutta pertscha | |
| CN114681378A (en) | Blackhead-derived cosmetic composition and preparation method thereof | |
| CN101732204A (en) | Cosmetic composition for removing acnes, preparation and preparation method thereof | |
| CN103623003B (en) | A kind of ZHENZHU MINGMU DIYANYE and preparation method thereof | |
| RU2450816C2 (en) | Compositions of hyaluronic acid salt for epithelial damages | |
| CN108158938A (en) | A kind of Pimple removing scream of the ingredient containing American cockroach and preparation method thereof | |
| KR20150112439A (en) | Pharmaceutical composition for prophylaxis and treatment of acne, skin external preparation, and method for producing extract of physostegia virginiana | |
| CN103816083A (en) | Acne-removing mark-removing transparent emulsion containing basic fibroblast growth factor and preparation method thereof | |
| CN110101639A (en) | Vigor frost and preparation method thereof | |
| CN109288884A (en) | A kind of preparation method and application of the Helianthi extract with repair of releiving | |
| CN114949089A (en) | Formula and preparation process of mite-killing and bacteriostatic medicine | |
| CN108030792A (en) | A kind of preparation process of the liquid anti-inflammatory sterilized composition of the propolis containing honey | |
| CN107376003A (en) | One kind is used to treat dermopathic medical dressing | |
| JP6474624B2 (en) | Caries remover | |
| JP2012532926A (en) | Soap composition for acne treatment containing ginseng absolute essential oil | |
| CN105296229A (en) | Passion flower soap and preparation method thereof | |
| CN108310348A (en) | A kind of preparation method of breath freshening spraying medicament | |
| WO2014016644A1 (en) | "chemical composition to obtain a product to remove carious tissue and process to obtain a carious tissue removing product" | |
| WO2019233158A1 (en) | Traditional chinese medicine gel composition, preparation method and use thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |