CN110314100A - It is a kind of for it is molten except in root canal cloves phenols charges remove Dinke composite formulations - Google Patents

It is a kind of for it is molten except in root canal cloves phenols charges remove Dinke composite formulations Download PDF

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Publication number
CN110314100A
CN110314100A CN201910624355.0A CN201910624355A CN110314100A CN 110314100 A CN110314100 A CN 110314100A CN 201910624355 A CN201910624355 A CN 201910624355A CN 110314100 A CN110314100 A CN 110314100A
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CN
China
Prior art keywords
parts
root canal
dinke
cloves
phenols
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CN201910624355.0A
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Chinese (zh)
Inventor
王林
秦颢
刘毅
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LONGLY BIOTECHNOLOGY (WUHAN) CO Ltd
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LONGLY BIOTECHNOLOGY (WUHAN) CO Ltd
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Priority to CN201910624355.0A priority Critical patent/CN110314100A/en
Publication of CN110314100A publication Critical patent/CN110314100A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00Preparations for dentistry
    • A61K6/50Preparations specially adapted for dental root treatment
    • A61K6/52Cleaning; Disinfecting
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00Preparations for dentistry
    • A61K6/50Preparations specially adapted for dental root treatment
    • A61K6/56Apical treatment

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  • Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dental Preparations (AREA)

Abstract

The invention discloses it is a kind of for it is molten except in root canal cloves phenols charges remove Dinke composite formulations, its of the invention raw material includes: 50-95 parts of tetrachloro-ethylene, 1-5 parts of sodium alginate, 1-5 parts of chitosan, 3-10 parts of creosote, 1-2 parts of citronellol, 1-2 parts of cosolvent, 1-2 parts of emulsifier and 1-2 parts of antioxidant by weight, and the present invention relates to tooth treatment technical field of pharmaceuticals.This for it is molten except in root canal cloves phenols charges remove Dinke composite formulations, it can be achieved by using tetrachloro-ethylene as major ingredient, cooperate traditional root canal file by using except Dinke, charges in root canal can effectively be removed, it is easy to operate, it helps himself freely to, operation is convenient for grasp, it is convenient to save time, good biocompatibility, toxic side effect is small, it is capable of providing good root-canal filling object dissolution removal ability, it realizes not only quick but also easily removes filler, achieve the purpose that thoroughly remove root canal filling material well, to greatly facilitate the treatment of dental patient.

Description

It is a kind of for it is molten except in root canal cloves phenols charges remove Dinke composite formulations
Technical field
The present invention relates to tooth treatment technical field of pharmaceuticals, specially a kind of to remove cloves phenols charges in root canal for molten Remove Dinke composite formulations.
Background technique
The success or not of root canal treatment is whether to completely remove the pathogeny stimulant in pulp cavity and root canal and tightly fills Root canal is filled out, to achieve the purpose that prevent periapical tissue from infecting again, however, finding that a large amount of root canals are controlled in daily clinic diagnosis The case of failure is treated, a portion is that patient comes discovery of going to a doctor after causing the positive signs such as pain, swelling, odontoseisis , another part is found due to taking the photograph X-ray film when repairing needs or routine inspection, is broken with or without apical area sclerotin It is bad, the reason of root canal treatment fails key factor be the curtailment of filler, density deficiency or both and and to have in root canal It, in the case that these root canal treatment failure needs row root canal re-treatment, successfully preservation is suffered from tooth and is filled dependent on original root canal The abundant removal of filling chock material thoroughly removes root canal filling material, then prepared bacteria removal and pathological tissues, re-starts strict Root-canal filling prevents from infecting again, when removing original root canal filling material, due to the complexity of root canal system, and original root-canal filling Material is not easy to remove completely, and clinical treatment operation needs to consume Dentist a large amount of time and energy, increases simultaneously The physician office visits of patient and time.
Sufficiently original filler plays an important role in the success of root canal re-treatment in removal root canal, is used alone and passes The root canal file larger workload of system, operating difficulties, have at present electronic file can improve remove root-canal filling object effect, but expense compared with Height, in economically less developed region Difficulty, disclosed by the invention to remove Dinke double solvents, effective component is tetrachloro-ethylene, Cooperate traditional root canal file by using except Dinke, can effectively remove charges in root canal, it is easy to operate, it helps himself freely to, operates Convenient for grasping, it is convenient to save time, and good biocompatibility, toxic side effect is small, is capable of providing good root-canal filling object dissolution removal Ability, at the same it is existing for it is molten except in root canal cloves phenols charges except Dinke viscosity it is smaller, pole in use Easily in trickling to the oral cavity of patient, patient is made to be easy to swallow down combination drug, so that the treatment zone to patient is next great It is inconvenient.
Summary of the invention
(1) the technical issues of solving
In view of the deficiencies of the prior art, the present invention provides it is a kind of for it is molten except in root canal cloves phenols charges remove fourth Gram composite formulations solve traditional root canal filling material removal larger workload, operating difficulties, costly, in economy The problem of under-developed area Difficulty.
(2) technical solution
In order to achieve the above object, the present invention is achieved by the following technical programs: one kind is for molten except cloves in root canal Phenols charges remove Dinke composite formulations, and raw material includes: 50-95 parts of tetrachloro-ethylene, sodium alginate 1-5 by weight Part, 1-5 parts of chitosan, 3-10 parts of creosote, 1-2 parts of citronellol, 1-2 parts of cosolvent, 1-2 parts of emulsifier and 1-2 parts of antioxidant.
Preferably, raw material includes following component: 73 parts of tetrachloro-ethylene, 3 parts of sodium alginate, 3 parts of chitosan, creosote 6 Part, 2 parts of citronellol, 1.5 parts of cosolvent, 1.5 parts of emulsifier and 1.5 parts of antioxidant.
Preferably, raw material includes following component: 50 parts of tetrachloro-ethylene, 1 part of sodium alginate, 1 part of chitosan, creosote 10 Part, 2 parts of citronellol, 2 parts of cosolvent, 2 parts of emulsifier and 2 parts of antioxidant.
Preferably, raw material includes following component: 95 parts of tetrachloro-ethylene, 5 parts of sodium alginate, 5 parts of chitosan, creosote 3 Part, 1 part of citronellol, 1 part of cosolvent, 1 part of emulsifier and 1 part of antioxidant.
Preferably, the cosolvent is one of sodium salicylate, p-aminobenzoic acid or acetamide or a variety of combinations.
Preferably, the antioxidant is the combination of one or both of thio-2 acid dibasic acid esters or double Lauryl Alcohol esters.
Preferably, the emulsifier is in sucrose ester, sorbose alcohol ester, lauric monoglyceride or methyl glycol fatty acid ester One or more combinations.
Preferably, preparation method specifically includes the following steps:
S1, tetrachloro-ethylene, sodium alginate, chitosan, the wood for measuring corresponding weight ratio part respectively by weighing equipment first Evaporate oil, citronellol, cosolvent, emulsifier and antioxidant, then each component after measurement is poured into storage tank save with It is standby to use;
S2, tetrachloro-ethylene, creosote and citronellol that step S1 is measured successively are poured into mixing agitator, is with revolving speed 400-500r/min, temperature stir 30-50min under conditions of being 26-32 DEG C, enable tetrachloro-ethylene, creosote and citronellol It is adequately mixed, to obtain premixed liquid;
S3, the cosolvent by step S1 is measured, sodium alginate, chitosan, emulsifier and antioxidant are added sequentially to step In the premixed liquid of S2 preparation, 1-2h is stirred with the revolving speed of 700-800r/min, so that each assistant medicament and premixed liquid be made to carry out It is sufficiently mixed stirring, to obtain double solvents;
S4, double solvents made from step S3 is subjected to filling process by bottle placer, then carries out quality inspection and packaging, most Sell or be put in storage afterwards storage.
Preferably, application method specifically includes the following steps:
T1. it is first turned on pulp cavity, exposure root canal orifice, dry cavities prevent saliva from flowing into;
T2, appropriate double solvents is put in pulp cavity, keep pulp cavity completely wet, but is no more than liquid spilling, then use broach Root canal orifice is found, liquid is imported in root canal, primitive root is gradually removed and fills material, it is longer that the liquid and root fill material time of contact, more easily goes Except raw material;
Double solvents is added dropwise at any time when T3, operation, pull lift action repeatedly is done in root canal, to dissolve filling material;
T4, original are filled after object is completely dissolved removal, then do root canal preparation, and be cleaned and dried root canal.
(3) beneficial effect
The present invention provides it is a kind of for it is molten except in root canal cloves phenols charges remove Dinke composite formulations.With it is existing Technology compared to have it is following the utility model has the advantages that
(1), this be used for it is molten except in root canal cloves phenols charges except Dinke composite formulations, raw material is by weight It include: 50-95 parts of tetrachloro-ethylene, 1-5 parts of sodium alginate, 1-5 parts of chitosan, 3-10 parts of creosote, 1-2 parts of citronellol, hydrotropy 1-2 parts of 1-2 parts of agent, 1-2 parts of emulsifier and antioxidant are, it can be achieved that by using tetrachloro-ethylene as major ingredient, by using except fourth Gram traditional root canal file of cooperation, can effectively remove charges in root canal, easy to operate, help himself freely to, operation is time saving convenient for grasping Between it is convenient, good biocompatibility, toxic side effect is small, is capable of providing good root-canal filling object dissolution removal ability, realizes both Filler quickly and is easily removed, has achieved the purpose that thoroughly remove root canal filling material well, to significantly facilitate The treatment of dental patient can greatly increase the toughness of combination drug by the way that sodium alginate and chitosan are added in ingredient, It avoids and easily trickles in use to the oral cavity of patient well, patient is made to be easy to swallow down combination drug, The case where causing damages to the health of patient, to ensure that the normal treatment of the safety of patient.
(2), this be used for it is molten except in root canal cloves phenols charges except Dinke composite formulations, preparation method specifically wraps Include following steps: S1, first by weighing equipment measure respectively the tetrachloro-ethylene of corresponding weight ratio part, sodium alginate, chitosan, Then each component after measurement is poured into storage tank and is saved by creosote, citronellol, cosolvent, emulsifier and antioxidant In case using, S2, tetrachloro-ethylene, creosote and citronellol that step S1 is measured successively are poured into mixing agitator, with revolving speed For 400-500r/min, temperature stirs 30-50min under conditions of being 26-32 DEG C, enables tetrachloro-ethylene, creosote and citronellol It is enough adequately mixed, to obtain premixed liquid, S3, is successively added cosolvent, emulsifier and antioxidant that step S1 is measured Enter in the premixed liquid prepared to step S2,1-2h is stirred with the revolving speed of 700-800r/min, to make each assistant medicament and pre- Mixed liquid carries out being sufficiently mixed stirring, to obtain double solvents, S4, carries out double solvents made from step S3 by bottle placer Then filling process carries out quality inspection and packaging, finally sell or be put in storage storage, it can be achieved that preparing by simple preparation process Double solvents greatly reduces the production cost of double solvents, while by using double solvents, can facilitate well will be filled Material removal.
Detailed description of the invention
Fig. 1 is the data statistic figure of application experiment of the present invention.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other Embodiment shall fall within the protection scope of the present invention.
Referring to Fig. 1, the embodiment of the present invention provides three kinds of technical solutions: one kind is for molten except cloves phenols filling in root canal Object specifically includes following embodiment except the preparation method of Dinke composite formulations:
Embodiment 1
S1,3 parts of 73 parts of tetrachloro-ethylenes, sodium alginate of corresponding weight ratio part, first measured by weighing equipment respectively first 3 parts, 6 parts creosotes of shell amine, 2 parts of citronellols, 1.5 parts of cosolvents, 1.5 parts of emulsifiers and 1.5 parts of antioxidant, after then measuring Each component pour into storage tank and save in case using, cosolvent is sodium salicylate, p-aminobenzoic acid and acetamide Composition, antioxidant are the composition of thio-2 acid dibasic acid esters and double Lauryl Alcohol esters, and emulsifier is sucrose ester, D-sorbite The composition of rouge, lauric monoglyceride and methyl glycol fatty acid ester;
S2, tetrachloro-ethylene, creosote and citronellol that step S1 is measured successively are poured into mixing agitator, is with revolving speed 450r/min, temperature stir 40min under conditions of being 30 DEG C, are able to carry out tetrachloro-ethylene, creosote and citronellol adequately Mixing, to obtain premixed liquid;
S3, the cosolvent by step S1 is measured, sodium alginate, chitosan, emulsifier and antioxidant are added sequentially to step In the premixed liquid of S2 preparation, 1.5h is stirred with the revolving speed of 750r/min, so that it is abundant to carry out each assistant medicament and premixed liquid It is mixed, to obtain double solvents;
S4, double solvents made from step S3 is subjected to filling process by bottle placer, then carries out quality inspection and packaging, most Sell or be put in storage afterwards storage.
Embodiment 2
S1,1 part of 50 parts of tetrachloro-ethylenes, sodium alginate of corresponding weight ratio part, first measured by weighing equipment respectively first 1 part, 10 parts creosotes of shell amine, 2 parts of citronellols, 2 parts of cosolvents, 2 parts of emulsifiers and 2 parts of antioxidant, then will be each after measurement Component, which is poured into storage tank, save in case using, and cosolvent is the composition in sodium salicylate and acetamide, and antioxidant is Thio-2 acid dibasic acid esters, emulsifier are the composition of sucrose ester and methyl glycol fatty acid ester;
S2, tetrachloro-ethylene, creosote and citronellol that step S1 is measured successively are poured into mixing agitator, is with revolving speed 400r/min, temperature stir 30min under conditions of being 26 DEG C, are able to carry out tetrachloro-ethylene, creosote and citronellol adequately Mixing, to obtain premixed liquid;
S3, the cosolvent by step S1 is measured, sodium alginate, chitosan, emulsifier and antioxidant are added sequentially to step In the premixed liquid of S2 preparation, 1h is stirred with the revolving speed of 700r/min, so that it is sufficiently mixed to carry out each assistant medicament and premixed liquid Stirring is closed, to obtain double solvents;
S4, double solvents made from step S3 is subjected to filling process by bottle placer, then carries out quality inspection and packaging, most Sell or be put in storage afterwards storage.
Embodiment 3
S1,5 parts of 95 parts of tetrachloro-ethylenes, sodium alginate of corresponding weight ratio part, first measured by weighing equipment respectively first 5 parts, 3 parts creosotes of shell amine, 1 part of citronellol, 1 part of cosolvent, 1 part of emulsifier and 1 part of antioxidant, then by each group after measurement It pours in separately and carries out saving in storage tank in case using, cosolvent is sodium salicylate, and antioxidant is double Lauryl Alcohol esters, and emulsifier is Sucrose ester;
S2, tetrachloro-ethylene, creosote and citronellol that step S1 is measured successively are poured into mixing agitator, is with revolving speed 500r/min, temperature stir 50min under conditions of being 32 DEG C, are able to carry out tetrachloro-ethylene, creosote and citronellol adequately Mixing, to obtain premixed liquid;
S3, the cosolvent by step S1 is measured, sodium alginate, chitosan, emulsifier and antioxidant are added sequentially to step In the premixed liquid of S2 preparation, 2h is stirred with the revolving speed of 800r/min, so that it is sufficiently mixed to carry out each assistant medicament and premixed liquid Stirring is closed, to obtain double solvents;
S4, double solvents made from step S3 is subjected to filling process by bottle placer, then carries out quality inspection and packaging, most Sell or be put in storage afterwards storage.
The present invention is a kind of for the molten application method for removing Dinke composite formulations except cloves phenols charges in root canal, has Body the following steps are included:
T1. it is first turned on pulp cavity, exposure root canal orifice, dry cavities prevent saliva from flowing into;
T2, appropriate double solvents is put in pulp cavity, keep pulp cavity completely wet, but is no more than liquid spilling, then use broach Root canal orifice is found, liquid is imported in root canal, primitive root is gradually removed and fills material, it is longer that the liquid and root fill material time of contact, more easily goes Except raw material;
Double solvents is added dropwise at any time when T3, operation, pull lift action repeatedly is done in root canal, to dissolve filling material;
T4, original are filled after object is completely dissolved removal, then do root canal preparation, and be cleaned and dried root canal.
Application test
Certain dental treatment outpatient service prepares three groups of double solvents using 1-3 of the embodiment of the present invention, then chooses four odontopathy and suffers from Person carries out application test, wherein three groups of double solvents, which are respectively adopted, in three patients carries out going for cloves phenols filler in root canals It removes, and a patient is removed using conventional root canal file, records each group removal time removal situation during the experiment.
By table Fig. 1 it is found that the double solvents removal time prepared using embodiment 1 is most short, and remove it is clean, without any residual Object is stayed, and the double solvents for using embodiment 2 and embodiment 3 to prepare is shorter than the conventional method removal time, and removes completely, adopts The used time longest of cloves phenols filler in root canal is removed with conventional root canal file, and removal is not clean, there is residue, therefore, The present invention can be achieved by using tetrachloro-ethylene to cooperate traditional root canal file by using except Dinke as major ingredient, can be effectively clear It is easy to operate except charges in root canal, it helps himself freely to, operation is convenient for grasping, and it is convenient to save time, good biocompatibility, and poison is secondary to be made With small, it is capable of providing good root-canal filling object dissolution removal ability, realizes and not only removes quickly but also easily filler, very It is good to have achieved the purpose that thoroughly remove root canal filling material, to greatly facilitate the treatment of dental patient.
It should be noted that, in this document, relational terms such as first and second and the like are used merely to a reality Body or operation are distinguished with another entity or operation, are deposited without necessarily requiring or implying between these entities or operation In any actual relationship or order or sequence.Moreover, the terms "include", "comprise" or its any other variant are intended to Non-exclusive inclusion, so that the process, method, article or equipment including a series of elements is not only wanted including those Element, but also including other elements that are not explicitly listed, or further include for this process, method, article or equipment Intrinsic element.
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with A variety of variations, modification, replacement can be carried out to these embodiments without departing from the principles and spirit of the present invention by understanding And modification, the scope of the present invention is defined by the appended.

Claims (9)

1. it is a kind of for it is molten except in root canal cloves phenols charges remove Dinke composite formulations, it is characterised in that: its raw material is pressed Weight part ratio includes: 50-95 parts of tetrachloro-ethylene, 1-5 parts of sodium alginate, 1-5 parts of chitosan, 3-10 parts of creosote, citronellol 1-2 Part, 1-2 parts of cosolvent, 1-2 parts of emulsifier and 1-2 parts of antioxidant.
2. it is according to claim 1 it is a kind of for it is molten except in root canal cloves phenols charges remove Dinke composite formulations, It is characterized by: its raw material includes following component: 73 parts of tetrachloro-ethylene, 3 parts of sodium alginate, 3 parts of chitosan, 6 parts of creosote, perfume 2 parts of thatch alcohol, 1.5 parts of cosolvent, 1.5 parts of emulsifier and 1.5 parts of antioxidant.
3. it is according to claim 1 it is a kind of for it is molten except in root canal cloves phenols charges remove Dinke composite formulations, It is characterized by: its raw material includes following component: 50 parts of tetrachloro-ethylene, 1 part of sodium alginate, 1 part of chitosan, 10 parts of creosote, 2 parts of citronellol, 2 parts of cosolvent, 2 parts of emulsifier and 2 parts of antioxidant.
4. it is according to claim 1 it is a kind of for it is molten except in root canal cloves phenols charges remove Dinke composite formulations, It is characterized by: its raw material includes following component: 95 parts of tetrachloro-ethylene, 5 parts of sodium alginate, 5 parts of chitosan, 3 parts of creosote, perfume 1 part of thatch alcohol, 1 part of cosolvent, 1 part of emulsifier and 1 part of antioxidant.
5. it is according to any one of claims 1-4 it is a kind of for it is molten except in root canal cloves phenols charges except Dinke it is multiple Close composition formula, it is characterised in that: the cosolvent is one of sodium salicylate, p-aminobenzoic acid or acetamide or a variety of Combination.
6. it is according to any one of claims 1-4 it is a kind of for it is molten except in root canal cloves phenols charges except Dinke it is multiple Close composition formula, it is characterised in that: the antioxidant is one or both of thio-2 acid dibasic acid esters or double Lauryl Alcohol esters Combination.
7. it is according to any one of claims 1-4 it is a kind of for it is molten except in root canal cloves phenols charges except Dinke it is multiple Close composition formula, it is characterised in that: the emulsifier is sucrose ester, sorbose alcohol ester, lauric monoglyceride or propylene glycol fatty One of acid esters or a variety of combinations.
8. it is according to any one of claims 1-4 it is a kind of for it is molten except in root canal cloves phenols charges except Dinke it is multiple Close composition formula, it is characterised in that: preparation method specifically includes the following steps:
S1, first by weighing equipment measure respectively the tetrachloro-ethylene of corresponding weight ratio part, sodium alginate, chitosan, creosote, Then each component after measurement is poured into storage tank and save in case making by citronellol, cosolvent, emulsifier and antioxidant With;
S2, tetrachloro-ethylene, creosote and citronellol that step S1 is measured successively are poured into mixing agitator, is 400- with revolving speed 500r/min, temperature stir 30-50min under conditions of being 26-32 DEG C, are able to carry out tetrachloro-ethylene, creosote and citronellol Adequately mixing, to obtain premixed liquid;
S3, the cosolvent by step S1 is measured, sodium alginate, chitosan, emulsifier and antioxidant are added sequentially to step S2 system In standby premixed liquid, 1-2h is stirred with the revolving speed of 700-800r/min, so that it is abundant to carry out each assistant medicament and premixed liquid It is mixed, to obtain double solvents;
S4, double solvents made from step S3 is subjected to filling process by bottle placer, then carries out quality inspection and packaging, finally goes out Sell or be put in storage storage.
9. it is according to claim 8 it is a kind of for it is molten except in root canal cloves phenols charges remove Dinke composite formulations, It is characterized by: its application method specifically includes the following steps:
T1. it is first turned on pulp cavity, exposure root canal orifice, dry cavities prevent saliva from flowing into;
T2, appropriate double solvents is put in pulp cavity, keep pulp cavity completely wet, but is no more than liquid spilling, then found with broach Root canal orifice imports liquid in root canal, gradually removes primitive root and fills material, and it is longer that the liquid and root fill material time of contact, easier removal original Material;
Double solvents is added dropwise at any time when T3, operation, pull lift action repeatedly is done in root canal, to dissolve filling material;
T4, original are filled after object is completely dissolved removal, then do root canal preparation, and be cleaned and dried root canal.
CN201910624355.0A 2019-07-11 2019-07-11 It is a kind of for it is molten except in root canal cloves phenols charges remove Dinke composite formulations Pending CN110314100A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61134306A (en) * 1984-12-03 1986-06-21 Sumitomo Chem Co Ltd Dental adhesive
CN104490855A (en) * 2014-12-18 2015-04-08 李柏霖 Dental chemical removal compound formula for root-canal filling of gutta pertscha

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61134306A (en) * 1984-12-03 1986-06-21 Sumitomo Chem Co Ltd Dental adhesive
CN104490855A (en) * 2014-12-18 2015-04-08 李柏霖 Dental chemical removal compound formula for root-canal filling of gutta pertscha

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
无: "武汉朗力生物除丁克(10ml)", 《个人图书馆,HTTP://WWW.360DOC.CN/MIP/585789513.HTML》 *
朗力生物医药(武汉)有限公司: "除丁克溶液", 《朗力生物医药(武汉)有限公司企业标准》 *

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