CN103007338B - Application of gel material for dental cavity filling material after tooth extraction - Google Patents
Application of gel material for dental cavity filling material after tooth extraction Download PDFInfo
- Publication number
- CN103007338B CN103007338B CN201110300722.5A CN201110300722A CN103007338B CN 103007338 B CN103007338 B CN 103007338B CN 201110300722 A CN201110300722 A CN 201110300722A CN 103007338 B CN103007338 B CN 103007338B
- Authority
- CN
- China
- Prior art keywords
- gel
- chitosan
- poly
- rubber material
- copolymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Abstract
The invention discloses application of a gel material in tooth extraction. The application is characterized in that the gel is applied to a tooth socket after a tooth is extracted to promote bone healing and formation of a new bone; the gel material is temperature-sensitive hydrogel or solvent-sensitive gel; the phase transition temperature of the temperature-sensitive hydrogel is in a range of 25 to 36 DEG C, namely when the temperature is lower than the phase transition temperature, the gel material is liquid, and when the temperature is higher than the phase transition temperature, the gel material is solid; and the solvent-sensitive gel means that the gel material is not dissolved in water but easily dissolved in a solvent, and the gel material is liquid when being dissolved in the solvent and solid after the solvent is reduced.
Description
Technical field
The present invention relates to the processing of alveolus surgery tooth extraction wound and the field of oral implantology, especially relate to gel rubber material is applied to after dental extraction, to promote tooth extraction wound knitting and to induce the formation of new bone.
Background technology
Dental extraction is alveolus surgery modal operation clinically, dental extraction is as a kind of surgical operation, inevitably cause the damage in various degree of art district soft tissue and sclerous tissues, produce the reactions such as hemorrhage, pain, swelling, also can cause general reaction in various degree simultaneously, can cause intensifying or increasing the weight of of other system disease, also very easily occur the complication such as alveolus infection, pain.The wound producing after operation is called tooth extraction wound.The agglutination of tooth extraction wound needs for a long time, and is not often very smooth, in actual mechanical process, has clinically a lot of problems to be solved.The malaise symptoms such as after exodontia, people usually can produce that gingiva is rubescent, swelling, tenderness and spontaneous pain, conventionally through 3 to 10, its symptom just can alleviate gradually, and finally in exodontia nest, clot machine changes into the new bone of bone formation healing.But if after extraction, wound has residue to fall into when exposing or eating meal, can produce a lot of serious infection.Stay next empty tooth nest because do not have blood clot or blood clot to decompose in exodontia nest, can cause taking anaerobe as main mixed cell and infect, such as dry socket etc.In addition, the maintenance of the absorption of alveolar bone to disappearance district's artificial tooth reparation and implantation body after exodontia, attractive in appearance and function all can exert an influence.Therefore, for avoiding producing above-mentioned symptom, people wish tooth extraction wound quickly-healing, and the new bone in exodontia nest generates rapidly.After exodontia, the absorption of alveolar ridge causes the variation of jaw structure and shape directly to affect the quality that artificial tooth is repaired.Experts and scholars both domestic and external are finding always and are effectively reducing the method that the rear alveolar ridge of exodontia absorbs.
At present, while implementing tooth pulling surgery in clinical oral cavity, take following measure more, to ensure the success of operation, and avoid postoperative infection.For example, whether inquiry patient has the easily hemorrhage physiological conditions such as hypertension, carries out disinfection in the preoperative; In the preoperative and implement operation and time internal environment of oral cavity is carried out to antiinflammatory; In art, reduce operating time etc. as far as possible; Pulling out after tooth, cramming exodontia nest hemostasis prevention infection with cotton balls, on tooth extraction wound surface, in both sides alveolar ridge, advising patient to sting reject after tight a period of time with the gauze lap crossbearer of sterilization.But, due to individual physique difference, the molding speed difference of blood clot, the patient after a lot of exodontias is spuing after Cotton Gossypii, can cause wound to expose, and then cause and infect.But except cramming with cotton balls, clinically tooth extraction wound is not had to other better processing method at present.
Summary of the invention
The technical problem to be solved in the present invention is to find a kind of method that can substitute Cotton Gossypii and cram exodontia nest hemostasis after dental extraction, better to process tooth extraction wound, avoid antibacterial to infect, promote knitting, wound healing simultaneously and induce the formation of new bone, shorten the cycle of tooth extraction wound knitting.
Technical scheme of the present invention is as follows:
1. the purposes of gel rubber material in dental extraction, is characterized in that described gel application in the tooth nest after exodontia to promote knitting and new bone formation; Wherein said gel rubber material is selected from: temperature sensitive type water gel or solvent responsive type gel; The phase transition temperature of described temperature sensitive type water gel is 25 DEG C of temperature in-36 DEG C of scopes, and when temperature is during lower than phase transition temperature, this gel rubber material is liquid, and when temperature is during higher than phase transition temperature, this gel rubber material is solid-state; Described solvent responsive type gel refers to that this gel rubber material is water insoluble, is soluble in other solvent, and in the time that it is dissolved in solvent, for liquid, after solvent reduces, it is solid-state.
2. according to 1 purposes, wherein said knitting is tooth extraction wound knitting.
3. according to 1 purposes, wherein said new bone formation is the new bone formation of induction of inducing after dental extraction in new bone formation and Dental Implant process.
4. according to the purposes of any one in 1-3, colloidal particle in wherein said gel rubber material accounts for gel rubber material gross weight: 10wt%-90wt%, preferably 20wt%-80wt%, more preferably 30wt%-70wt%, more preferably 40wt%-60wt%, surplus is disperse medium.
5. according to 4 purposes, wherein said temperature sensitive type water gel is selected from: poly N-isopropyl acrylamide gel, poly-N-isopropyl acrylamide-methyl methacrylate-methacrylic acid copolymer gel, the graft copolymer gel of poly-N-isopropyl acrylamide-poly 2-hydroxyethyl methacrylate, poly-N-isopropyl acrylamide-acrylic copolymer gel, NIPA-sodium acrylate copolymer gel, poly-N-isopropyl acrylamide-amino lactobionic acid gel, NIPA-poly 4 vinyl pyridine copolymer gel, poly-(NIPA-acrylic acid methyl ester .-propylene hydrazides)-sodium alginate copolymer gel, poloxamer gel, PGA gel, polylactide gel, poly (glycolide-co-lactide)-ethylene glycol copolymer gel, poly (glycolide-co-lactide)-polyethylene glycol-Acetic acid, hydroxy-, bimol. cyclic ester lactide triblock copolymer gel, Poly(D,L-lactide-co-glycolide gel, chitin hydrogel, carboxy chitin gel, chitosan gel rubber, low chitosan gel rubber, O-carboxymethyl chitin gel, N-carboxymethyl chitosan gel, CMC gel, hydroxyethyl chitosan gel, ethyl chitosan gel, butyl chitosan gel rubber, octyl group chitosan gel rubber, cetyl-chitosan gel, hydroxypropyl chitosan gel, chitosan quaternary ammonium salt gel, N-phthalyl chitosan gel rubber, ethoxy propyl group chitosan gel rubber, chitosan sulfate gels, xylan gel, pluronic-acrylate copolymer gel, gellan gum-hyaluronic acid polymer gel, carbomer gel, mono methoxy polyethylene glycol-polycaprolactone block polymer gel, N-isopropylacrylamide-chitosan polymer gel, alginate gel, gelatin, agar gel, collagen, carrageenin, methyl cellulose gel, hydroxypropyl emthylcellulose gel, polyphosphazene gel, chitosan-glycerophosphate gel, chitosan-polyvinyl alcohol-bicarbonate pluralgel, cellulose graft cyclodextrin gel, polyvinyl methyl ether gel, polymethyl acid gel, polyvinyl alcohol-vinyl acetate copolymerized body gel, polyvinyl alcohol gel, polycarboxylic acids gel, polyamide gels, poly-(N-vinyl alkylamine) gel, polyvinyl alcohol-chitosan plural gel, vinyl pyrrolidone-methacrylic acid-N, N dimethylamine ethyl ester copolymer gel, poly-N, N-oxalyl group acrylamide gel, propenoic acid beta-hydroxy propyl ester-vinylpyrrolidone copolymer gel, N-vinylpyridine borofluoride gel, N-methyl-4-vinylpridine Methylsulfate salt gel, poly-N-(methyl) acryloyl group amino-acid ester gel, soybean protein-carboxymethyl chitosan copolymer gel, sodium alginate-chitosan pluralgel, sodium alginate-gelatine-chitosan pluralgel, polyethers-chitosan plural gel, polyvinyl alcohol-chitosan-collagen copolymer gel, polyanion cellulose-hydroxypropyl emthylcellulose pluralgel, poly-anhydride gel, resinae gel, phenols gel etc.Preferred: polylactic acid gel, PLGA gel, poly-anhydride gel, polyamide gels, chitin hydrogel, cellulose graft cyclodextrin gel, polyvinyl methyl ether gel, carbomer gel, Sargassum polysaccharides gel, agar gel, poloxamer gel, chitosan-polyvinyl alcohol-bicarbonate pluralgel, polyvinyl alcohol gel, methyl cellulose gel etc.; More preferably: polylactic acid gel, PLGA gel, polyamide gels, poly-anhydride gel, poloxamer gel, Sargassum polysaccharides gel, polyvinyl alcohol gel etc.
6. according to 4 purposes, wherein said solvent responsive type gel is selected from: Sucrose acetoisobutyrate gel, poly-asparagine gel, poly-(tert-butyl group carbon oxygen carboxymethyl) glutamic acid gel, polyaniline-polyethylene glycol-aniline triblock copolymer gel, guar gum, carboxymethyl propyl group guar gum; Solvent is selected from: one or more in the solution such as methanol, ethanol, dimethyl sulfoxide, EDTA, ethyl lactate, N-Methyl pyrrolidone.Preferably Sucrose acetoisobutyrate gel and polyaniline-polyethylene glycol-aniline triblock copolymer gel, solvent preferred alcohol.
7. according to 4 purposes, in wherein said gel rubber material, except colloidal particle and disperse medium, also comprise other component, it is selected from: one or more in hydroxyacetic acid, glycerol, glycerophosphate, acetin, the phosphate buffer that contains the pH7.4 of tween, alginate, calcium salt; Other component accounts for the 0-80wt% of gel rubber material gross weight, preferably 0-70wt%, more preferably 0-60wt%, more preferably 0-50wt%, more preferably 0-30wt%.
Technical scheme of the present invention can reach following technique effect:
1. gel rubber material of the present invention is applied in the tooth socket after dental extraction, not only can accelerates blood coagulation, induce new bone formation, can also be anticorrosion, granulation promoting broad-spectrum sterilization, medicine is evenly distributed in tooth socket, the generation of prevention infection and complication.
2. use gel rubber material of the present invention can well fill the tooth socket after exodontia, make wound reduce also can suppress the too much absorption of alveolar bone, make the damaged recovery of bone fast, enforcement tooth-planting art that can be early, shorten the whole cycle of Dental Implant, as implement Implant at once, described material also can promote the bone of implantation body to integrate.
3. gel rubber material of the present invention can be degraded in time, injection add stifled after without subsequent treatment; Due to its special character, also can all in tooth socket, remove at any time as the case may be.
Gel rubber material of the present invention is applied in dental extraction, is mainly based on following reason:
The gel rubber material that the present invention uses is temperature sensitive type water gel or solvent responsive type gel, and himself has bacteriostasis, and it can be degraded in time.
The characteristic of temperature sensitive type water gel is that gel rubber material becomes collosol state, is free-pouring liquid, is easy to injection when gel rubber material is in temperature during lower than phase transition temperature; Temperature is increased to phase transition temperature when above, and gel rubber material undergoes phase transition, and forms non-chemically crosslinked solid gel, is easy to cram.The phase transition temperature of this temperature sensitive type water gel is 25 DEG C of temperature in-36 DEG C of scopes, and above-mentioned phase transition process is reversible, and solid-state-liquid transformation can occur again in the time that temperature reduces.
Solvent responsive type gel rubber material is water insoluble, but is soluble in solvent, and after it is by dissolution with solvents, viscosity reduces, and forms the liquid form with mobility, is easy to injection; After this solution is injected in vivo, solvent reduces so that lose rapidly under the dilution of body fluid or in being exposed to air, and due to minimizing or the disappearance of solvent, in the aqueous environments of oral cavity, solvent responsive type gel rubber material is separated out with solid-state form, thereby crams exodontia nest.If do not feel like oneself, or other reason, can gargle with solvent, by solvent responsive type gel rubber material band outlet plenum.
Because above-mentioned gel rubber material has special mushy stage property of transition, it can be injected when the liquid state in exodontia nest, it changes rapidly the solid-state tooth extraction wound of cramming in oral environment, can not only stop blooding, promote blood coagulation, wound is lowered, promote the healing of tooth extraction wound and the generation of new bone, and the antibacterial infection of having avoided wound to expose causing.In addition, the too much absorption that it can also suppress alveolar bone, forms the second best in quality implant bed bone form, and making to implement early Implant becomes possibility, shortens the cycle of Dental Implant.Above-mentioned gel rubber material is easy to use clinically, as patient does not feel well, can gargle its removing with cold water or solvent immediately.
Brief description of the drawings
Fig. 1: the X-ray examination result of blank group;
The X-ray examination result of Fig. 2: embodiment 1 experimental group.
Detailed description of the invention
Following embodiment is only representative test of the present invention, and temperature sensitive type water gel of the present invention and solvent responsive type gel can be because the difference of preparation method affects its purposes, and commercially available gel rubber material also can be for the present invention.
1. in vivo test:
Get body weight 180-220g, the adult rat that male and female are not limit, some, be divided at random two groups of experimental group and matched groups, to rat exodontia, and the periodontal tissue in tooth socket struck off, suitably use normal saline flushing, experimental group injection liquid gel rubber material, blank group is stopped blooding with sterilization lap.Postoperative respectively at the different time inspection of drawing materials.
2. detection method
1) alkali phosphatase (ALP) activity and determination of calcium content:
Get cold preservation specimen, its surperficial soft tissue is eliminated, weigh, put refiner, homogenate, 8000～10000rpm with the 2ml normal saline of ice pre-cooling, centrifugal 10～15 minutes, get supernatant 100 μ l, add 1～3mM 4-NPP, 30～50 μ l, hatch 10～15 minutes for 37 DEG C, add 1～3N NaOH, 40～50 μ l cessation reactions, ultraviolet spectrophotometer, wavelength 410nm place measure OD value, taking specimen weight in wet base as divisor, calculate the U/mg of the unit tissue (weight in wet base) of ALP.Get above-mentioned centrifuged deposit and add 0.5N HCl 2.5ml dissolving, HCl concentration is adjusted to 1% (wherein containing 10% strontium nitrate 2.5ml), atomic absorption spectrophotometer is surveyed calcium content, taking specimen weight in wet base as divisor, calculates calcium content μ g/mg tissue (weight in wet base).
Alkali phosphatase (ALP) is the desirable biochemical metabolism index of reflection bone metabolism situation, is a kind of phosphomonoesterase, and the ALP in skeleton is osteoplastic Specific marker.Calcium is the cation that in-vivo content is maximum, and skeleton is calcium warehouse maximum in body, and the variation of calcium content directly reflects the active degree of bone metabolism situation.
2) immunohistochemical detection:
Paraffin section routine dewaxes to water, 3%H
2o
2hatch 10～20 minutes with blocking-up, the endogenic peroxidase of deactivation in 37 DEG C, rinse 2～3 times containing the phosphate buffer of the pH7.4 of 0.05% tween 20, through the sealing of serum working solution, hatch 10～20 minutes for 37 DEG C, liquid inclines.Drip the streptomycin avidin working solution of peroxidase labelling, hatch 20～40 minutes in 37 DEG C, PBS rinses 2～3 times each 5～8 minutes, DAB dyeing, observed result.
3) X-ray examination:
By blank group and experimental group, carry out respectively X ray detection.
Embodiment 1-7
The preparation of Sargassum polysaccharides hydrogel material: the dissolving with hydrochloric acid by Sargassum polysaccharides with 0.1mol/L, be mixed with certain density solution, place in refrigerator for subsequent use.Take in the distilled water that a certain amount of sodium β-glycerophosphate is dissolved in 1mL, be mixed with aqueous solution.By Sargassum polysaccharides solution for subsequent use and sodium β-glycerophosphate aqueous solution, in ice bath, place 15min simultaneously.Then the aqueous solution of sodium β-glycerophosphate is dropwise splashed into syringe in the colloid solution that continues to stir, after mixing, continue to stir 20min, form Sargassum polysaccharides-sodium glycerophosphate hydrogel material, wherein Sargassum polysaccharides accounts for the 40wt% of gel gross weight, and sodium glycerophosphate accounts for 35wt%.Carry out respectively the detection of above-mentioned three kinds of methods.
Embodiment 2: prepare polyvinyl methyl ether-glycerol liquor gel by the method for embodiment 1, wherein polyvinyl methyl ether accounts for the 50wt% of gel gross weight, and glycerol accounts for 15wt%;
Embodiment 3: commercially available chitosan-polyvinyl alcohol-sodium bicarbonate composite aquogel, wherein chitosan-polyvinyl alcohol accounts for the 30wt% of gel gross weight, and sodium bicarbonate accounts for the 10wt% of gel gross weight;
Embodiment 4: commercially available polylactic acid hydrogel, wherein polylactic acid accounts for the 70wt% of gel gross weight;
Embodiment 5: solvent responsive type gel is from commercially available Sucrose acetoisobutyrate, and solvent is ethanol (accounting for the 70wt% of gel gross weight);
Embodiment 6: the polylactic acid temperature sensitive type water gel of hydroxyl acetic acid 60wt%, wherein polylactic acid accounts for the 20wt% of gel gross weight;
Embodiment 7: commercially available poloxamer hydrogel, wherein poloxamer accounts for the 90wt% of gel gross weight.
Testing result is in table 1 (testing result of embodiment 1-7 is expressed as experimental group 1-7).
Table 1.ALP activity and determination of calcium content result
Note: 1～7 group of difference of blank group and experiment has statistical significance, * P < 0.05, * * P < 0.01
Result shows: the gel rubber material of embodiment of the present invention 1-7 has good promotion bone wound healing, reduces or prevent the effect of frontal resorption.
Embodiment 1 immunohistochemical detection result shows: in one week rear tooth socket of blank group exodontia, hemocyte and early stage granulation are obviously less than experimental group, and find inflammatory cell.After exodontia surrounding, in experimental group, can see cube, polygonal osteoblast increases, obviously active near osseous tissue place osteoblast, start to have new osteogenesis; The knitting of blank group is bad, and the more fibroblast of fibroid sclerotin, bone source sexual cell mix, wherein visible neutrophilic granulocyte.
Embodiment 2-7 immunohistochemical detection result is identical with embodiment 1.
3) the X-ray examination result of embodiment 1 shows: observe through X ray, after exodontia surrounding, the boundary of tooth socket can see on X ray sheet, and in experimental group tooth socket, new bone formation is obvious; The new bone formation of entirety in blank group tooth socket is not obvious, bone trabecula is more chaotic.
The X-ray examination result of embodiment 2-7 is identical with embodiment 1.
Embodiment 8
Frontal resorption situation checks: select some of healthy adult mongrels, both sexes have concurrently, and body weight 15～20kg is divided into blank group and experimental group at random.After 2% Nembutal vein anesthetic, pull out both sides lower jaw the 2nd, 4 premolarss, in the tooth extraction wound of experimental group, insert various gel rubber materials, whole exodontia nest is filled up in compacting, and routine disinfection lap hemostasis for blank group is suitably peeled off cheek-tongue side mucoperiosteum after gingiva subtracts and drawn tight sewing-up cut over to one's side.In the form of postoperative 24 weekly check alveolar ridges and measure height of alveolar ridge.
Two groups of frontal resorption situation measurement results when table 8. the 24th week
Result shows that this tests gel rubber material used and have the effect of good promotion bone wound healing, and can suppress the absorption of alveolar bone.
Claims (10)
1. gel rubber material is filled a purposes for tooth nest material after as dental extraction, it is characterized in that described gel rubber material to be applied in the tooth socket after exodontia to promote tooth extraction wound knitting, wound healing and the new bone formation of induction, wherein said gel rubber material is selected from: temperature sensitive type water gel or solvent responsive type gel, the phase transition temperature of described temperature sensitive type water gel is 25 DEG C of temperature in-36 DEG C of scopes, and when temperature is during lower than phase transition temperature, this gel rubber material is liquid, and when temperature is during higher than phase transition temperature, this gel rubber material is solid-state, described solvent responsive type gel refers to that this gel rubber material is water insoluble, is soluble in other solvent of non-water, and in the time that it is dissolved in solvent, for liquid, after solvent reduces, it is solid-state, wherein said temperature sensitive type water gel is selected from: poly N-isopropyl acrylamide gel, poly-N-isopropyl acrylamide-methyl methacrylate-methacrylic acid copolymer gel, the graft copolymer gel of poly-N-isopropyl acrylamide-poly 2-hydroxyethyl methacrylate, poly-N-isopropyl acrylamide-acrylic acid copolymer hydrogel gel, NIPA-sodium acrylate copolymer gel, poly-N-isopropyl acrylamide-amino lactobionic acid gel, NIPA-poly 4 vinyl pyridine copolymer gel, poly-(NIPA-acrylic acid methyl ester .-propylene hydrazides)-sodium alginate copolymer gel, poloxamer gel, poly (glycolide-co-lactide)-polyethylene glycol-Acetic acid, hydroxy-, bimol. cyclic ester lactide triblock copolymer gel, Poly(D,L-lactide-co-glycolide gel, chitin hydrogel, carboxy chitin gel, chitosan gel rubber, O-carboxymethyl chitin gel, N-carboxymethyl chitosan gel, CMC gel, hydroxyethyl chitosan gel, ethyl chitosan gel, butyl chitosan gel rubber, octyl group chitosan gel rubber, cetyl-chitosan gel, hydroxypropyl chitosan gel, chitosan quaternary ammonium salt gel, N-phthalyl chitosan gel rubber, ethoxy propyl group chitosan gel rubber, chitosan sulfate gels, xylan gel, pluronic-acrylate copolymer gel, gellan gum-hyaluronic acid polymer gel, carbomer gel, mono methoxy polyethylene glycol-polycaprolactone block polymer gel, N-isopropylacrylamide-chitosan polymer gel, alginate gel, gelatin, agar gel, collagen, carrageenin, methyl cellulose gel, hydroxypropyl emthylcellulose gel, polyphosphazene gel, chitosan-glycerophosphate gel, chitosan-polyvinyl alcohol-bicarbonate pluralgel, cellulose graft cyclodextrin gel, polyvinyl methyl ether gel, polymethyl acid gel, polyvinyl alcohol-vinyl acetate copolymerized body gel, polyvinyl alcohol gel, poly-(N-vinyl alkylamine) gel, polyvinyl alcohol-chitosan plural gel, vinyl pyrrolidone-methacrylic acid-N, N dimethylamine ethyl ester copolymer gel, poly-N, N-oxalyl group acrylamide gel, propenoic acid beta-hydroxy propyl ester-vinylpyrrolidone copolymer gel, N-vinylpyridine borofluoride gel, N-methyl-4-vinylpridine Methylsulfate salt gel, poly-N-(methyl) acryloyl group amino-acid ester gel, soybean protein-carboxymethyl chitosan copolymer gel, sodium alginate-chitosan pluralgel, sodium alginate-gelatine-chitosan pluralgel, polyethers-chitosan plural gel, polyvinyl alcohol-chitosan-collagen copolymer gel, polyanion cellulose-hydroxypropyl emthylcellulose pluralgel, phenols gel, described solvent responsive type gel is selected from: Sucrose acetoisobutyrate gel, poly-asparagine gel, poly-(tert-butyl group carbon oxygen carboxymethyl) glutamic acid gel, polyaniline-polyethylene glycol-aniline triblock copolymer gel, guar gum, carboxymethyl propyl group guar gum, solvent is selected from: one or more in methanol, ethanol, dimethyl sulfoxide, EDTA, ethyl lactate, N-Methyl pyrrolidone.
2. according to the purposes of claim 1, wherein said new bone formation is to implement to induce the new bone formation of induction in new bone formation and Dental Implant process after dental extraction.
3. according to the purposes of claim 1 or 2, the colloidal particle in wherein said gel rubber material accounts for gel rubber material gross weight: 10wt%-90wt%, surplus is disperse medium.
4. according to the purposes of claim 3, wherein said temperature sensitive type water gel is selected from: polycarboxylic acids gel, poly-anhydride gel, polyamide gels, PLGA gel, chitin hydrogel, cellulose graft cyclodextrin gel, polyvinyl methyl ether gel, carbomer gel, Sargassum polysaccharides gel, agar gel, poloxamer gel, chitosan-polyvinyl alcohol-bicarbonate pluralgel, polyvinyl alcohol gel, methyl cellulose gel.
5. according to the purposes of claim 3, wherein said temperature sensitive type water gel is selected from: polylactic acid gel, PLGA gel, polyamide gels, poly-anhydride gel, poloxamer gel, Sargassum polysaccharides gel, polyvinyl alcohol gel.
6. according to the purposes of claim 3, wherein said solvent responsive type gel is selected from: Sucrose acetoisobutyrate gel or polyaniline-polyethylene glycol-aniline triblock copolymer gel, solvent is selected from ethanol.
7. according to the purposes of claim 3, the colloidal particle in described gel rubber material accounts for gel rubber material gross weight: 20wt%-80wt%, surplus is disperse medium.
8. according to the purposes of claim 3, the colloidal particle in described gel rubber material accounts for gel rubber material gross weight: 30wt%-70wt%, surplus is disperse medium.
9. according to the purposes of claim 3, in wherein said gel rubber material, except colloidal particle and disperse medium, also comprise other component, it is selected from: one or more in hydroxyacetic acid, glycerol, glycerophosphate, acetin, the phosphate buffer that contains the pH7.4 of tween, alginate, calcium salt; Other component accounts for the 0-80wt% of gel rubber material gross weight.
10. according to the purposes of claim 9, other component accounts for the 0-60wt% of gel rubber material gross weight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110300722.5A CN103007338B (en) | 2011-09-28 | 2011-09-28 | Application of gel material for dental cavity filling material after tooth extraction |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110300722.5A CN103007338B (en) | 2011-09-28 | 2011-09-28 | Application of gel material for dental cavity filling material after tooth extraction |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103007338A CN103007338A (en) | 2013-04-03 |
| CN103007338B true CN103007338B (en) | 2014-10-22 |
Family
ID=47956798
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201110300722.5A Active CN103007338B (en) | 2011-09-28 | 2011-09-28 | Application of gel material for dental cavity filling material after tooth extraction |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103007338B (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106310347B (en) * | 2015-06-30 | 2019-05-14 | 中国科学院上海硅酸盐研究所 | A kind of responsive to temperature type skin wound dressing and its preparation method and application |
| TWI561570B (en) * | 2016-02-05 | 2016-12-11 | Chen Ming Hung | The formula of solvent-evaporated forming hydrogel matrix and its manufacturing method |
| CN105622903B (en) * | 2016-03-16 | 2017-09-29 | 四川大学 | A kind of responsive to temperature type multicomponent block polymer and its preparation method and application |
| CN108057128A (en) * | 2017-12-12 | 2018-05-22 | 常州美帛纺织品有限公司 | A kind of preparation method of medical sodium alginate composite membrane |
| CN108703826A (en) * | 2018-04-09 | 2018-10-26 | 复旦大学附属华山医院 | It is a kind of to be molded endovascular stent system at once |
| CN109224120B (en) * | 2018-10-17 | 2021-08-03 | 西北大学 | In-situ injectable temperature-sensitive response hydroxypropyl chitosan composite hydrogel for lacrimal passage embolism and preparation method and application thereof |
| CN109663146A (en) * | 2019-02-01 | 2019-04-23 | 浙江大学 | A kind of antibacterial, the temperature sensitive chitosan gel rubber dressing of injection type and preparation method thereof |
| KR102093660B1 (en) * | 2019-07-08 | 2020-03-26 | (주)리젠바이오참 | Temperature-sensitive tissue adhesion prevention hydrogel composition and its manufacturing method |
| CN111632189B (en) * | 2020-05-27 | 2021-12-14 | 深圳先进技术研究院 | Injectable hydrogel hemostatic based on marine-derived gelatin, and application method thereof |
| CN111803701A (en) * | 2020-06-15 | 2020-10-23 | 中国人民解放军海军特色医学中心 | Preparation method of antibacterial drug-loaded cyclo-gamma-polyglutamic acid modified hydrogel |
| CN111803702A (en) * | 2020-06-15 | 2020-10-23 | 中国人民解放军海军特色医学中心 | Preparation method of growth factor-loaded cyclo-gamma-polyglutamic acid modified hydrogel |
| CN112023123B (en) * | 2020-09-09 | 2022-03-11 | 烟台博昊信息科技有限公司 | Antibacterial gel material for oral restoration and preparation method thereof |
| CN112608431A (en) * | 2020-11-03 | 2021-04-06 | 华南理工大学 | Ion-conductive hydrogel and preparation method and application thereof |
| CN113797385B (en) * | 2021-08-18 | 2022-05-24 | 山东大学 | Chitosan/polyethylene glycol hydrogel and preparation method and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2112177A1 (en) * | 2007-01-17 | 2009-10-28 | Kuraray Medical Inc. | Polymerizable monomer-containing composition |
| CN101636420A (en) * | 2007-01-17 | 2010-01-27 | 日本可乐丽医疗器材株式会社 | Polymerizable monomer, polymerizable composition and dental material |
-
2011
- 2011-09-28 CN CN201110300722.5A patent/CN103007338B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2112177A1 (en) * | 2007-01-17 | 2009-10-28 | Kuraray Medical Inc. | Polymerizable monomer-containing composition |
| CN101636420A (en) * | 2007-01-17 | 2010-01-27 | 日本可乐丽医疗器材株式会社 | Polymerizable monomer, polymerizable composition and dental material |
Non-Patent Citations (1)
| Title |
|---|
| 马志伟，张勇杰，吴织芬，王荣，朱浩，李媛，许杰，刘青.缓释骨形态发生蛋白-2的壳聚糖温敏凝胶促进牙周组织再生的实验研究.《华西口腔医学杂志》.2008,第26卷(第1期), * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103007338A (en) | 2013-04-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103007338B (en) | Application of gel material for dental cavity filling material after tooth extraction | |
| Muzzarelli et al. | Reconstruction of parodontal tissue with chitosan | |
| Cao et al. | Bone regeneration using photocrosslinked hydrogel incorporating rhBMP-2 loaded 2-N, 6-O-sulfated chitosan nanoparticles | |
| CN104888263B (en) | Biocompatible hemostatic prevents adhesion, promoting healing, the closed modified starch material of surgery | |
| CN103347901B (en) | Glucan composition | |
| CA2817405C (en) | Medical absorbable hemostatic material for bone wounds and preparation method therefor | |
| Huja et al. | Effects of short-term zoledronic acid treatment on bone remodeling and healing at surgical sites in the maxilla and mandible of aged dogs | |
| CN106492285A (en) | Injectable Acellular cartilaginous matrix particulate and its application in implant | |
| Malik et al. | Thyroxine-loaded chitosan/carboxymethyl cellulose/hydroxyapatite hydrogels enhance angiogenesis in in-ovo experiments | |
| CN103006444A (en) | Use of gel material in therapeutic process of dental disease | |
| CN108837184A (en) | A kind of composite membrane and preparation method thereof for Guided Bone Regeneration | |
| CN102120033A (en) | Collagen sustained-release carrier material for promoting repair of various traumas in oral and maxillofacial regions and method for preparing same | |
| CN106492288A (en) | Injectable de- cellular fat matrix particles and its application in implant | |
| CN107158452A (en) | A kind of bone surface of a wound hemostatic composition and its preparation method and application | |
| CN104693476B (en) | A kind of biodegradable medical sthptic sponge and preparation method thereof | |
| CN103830111A (en) | Polylactic acid aquagel and application thereof | |
| Venkatesan et al. | Clinical efficacy of amniotic membrane with biphasic calcium phosphate in guided tissue regeneration of intrabony defects-a randomized controlled clinical trial | |
| Abdul-Monem et al. | Light-cured hyaluronic acid composite hydrogels using riboflavin as a photoinitiator for bone regeneration applications | |
| CN103830767A (en) | Sucrose acetate isobutyrate gel and application thereof | |
| CN110755695A (en) | Chitosan gel with physiological responsiveness and application thereof in uterine cavity anti-adhesion | |
| Lee et al. | Orodispersible hyaluronic acid film delivery for oral wound healing in rats | |
| Yin et al. | Advanced biomaterials for promoting endometrial regeneration | |
| Johri et al. | Effect of amniotic membrane and platelet‐rich fibrin membrane on bone healing post endodontic surgery: An ultrasonographic, randomized controlled study | |
| CN109125812A (en) | A kind of composite membrane and preparation method thereof for Guided Bone Regeneration | |
| Yuan et al. | Observation on the effect of bone grafting alone and guided tissue regeneration combined with bone grafting to repair periodontal intraosseous defects |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |