CN108703826A - It is a kind of to be molded endovascular stent system at once - Google Patents
It is a kind of to be molded endovascular stent system at once Download PDFInfo
- Publication number
- CN108703826A CN108703826A CN201810312649.5A CN201810312649A CN108703826A CN 108703826 A CN108703826 A CN 108703826A CN 201810312649 A CN201810312649 A CN 201810312649A CN 108703826 A CN108703826 A CN 108703826A
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- China
- Prior art keywords
- capsule
- mother bulb
- bulbec
- channel
- conduit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
- A61F2/958—Inflatable balloons for placing stents or stent-grafts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/105—Balloon catheters with special features or adapted for special applications having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
Abstract
It being molded endovascular stent system, including balloon system, transport system, drug stent system at once the present invention relates to a kind of；The balloon system includes mother bulb capsule and bulbec capsule, and the bulbec capsule setting is in female balloon interior, the axis collinear of the axis of the bulbec capsule and the mother bulb capsule；The surface surrounding of the mother bulb capsule is provided with equally distributed micropore, and the micropore is one-way conduction hole；The transport system includes conduit, and the conduit includes first passage, second channel, silk guide passage；The drug stent system includes temperature sensitivity degradable liquid substance, and the temperature sensitivity degradable liquid substance forms drug stent on the outside of the mother bulb capsule.It the advantage is that, eliminating holder mesh does not have the shortcomings that medicine, and locally load concentration is low and uniform for vascular wall, and endothelialization postpones caused by can reducing part load concentration height, and it is unstable to reduce the effect of local drug concentration unevenness causes；Degradable characteristic is suitble to treat repeatedly the patient of restenosis.
Description
Technical field
The present invention relates to the field of medical instrument technology, more particularly to a kind of molding endovascular stent system at once.
Background technology
Blood vessel is the pipeline that blood flows through, and is dispersed throughout whole body.When there is Serious Stenosis, occlusion in blood vessel especially artery,
Local organization may occur in which hypoxic-ischemic, necrosis or even decreased organ function even failure.Angioplasty is by various means
So that lesion vessels is led to again, restores local organization blood supply.
Common angioplasty has balloon dilatation, holder to put art etc., complete in addition to heart, skull cerebrovascular for treating
The vascular lesions such as the vascular lesion at other positions of body, especially limb vessel, liver vessel and renal artery stenosis.
Blood saccule dilatation is that distensible foley's tube is placed in narrow blood vessel section after percutaneous puncture blood vessel, is passed through
Blood vessel " is got through " in the physical expansion of sacculus.It is on the basis of balloon expandable shapes, in lesion merging that holder, which puts art,
Holder reduces blood vessel elasticity retraction and moulding again, the purpose for keeping tube chamber blood flow unobstructed to reach support stenosis occlusion section blood vessel,
Has the function of pre- anti-restenosis.
However existing holder places art, holder mesh does not have medicine, and locally load concentration is uneven for vascular wall, goes out
Current situation portion carries endothelialization caused by concentration height and postpones, and curative effect is unstable；Surgical procedure easily causes interlayer：Operation is complicated, operation
It is cumbersome, it repeatedly needs repeatedly to replace stent system when implantation, increases operating time, to increase radiation exposure, expense
It is high, be not suitable for the vascular treatment of Long lesion, endangium tearing that violence dilating sacculus brings can not be solved and interlayer is asked
Topic；Easily there is adherent bad problem and BVS breakage problems in biodegradable stent, and OCT is needed to assist.
Therefore, there is an urgent need for one kind, and vascular wall load concentration can be made low and uniform, and operation is easy, easy to operate, low-cost,
Solve the problems, such as the adherent bad endovascular stent of biodegradable stent.
Invention content
The purpose of the present invention is being directed to deficiency in the prior art, a kind of molding endovascular stent system at once is provided.
To achieve the above object, the technical solution adopted by the present invention is that：
It is a kind of to be molded endovascular stent system, including balloon system, transport system, drug stent system at once；
The balloon system includes mother bulb capsule and bulbec capsule, and the bulbec capsule setting is in female balloon interior, the son
The axis collinear of the axis of sacculus and the mother bulb capsule, the mother bulb capsule is identical with the length of the bulbec capsule, the institute after expansion
The diameter for stating bulbec capsule is less than the diameter of the mother bulb capsule after expansion；
The surface surrounding of the mother bulb capsule is provided with equally distributed micropore, and the micropore is one-way conduction hole, is used for institute
It states mother bulb capsule and conveys substance from inside to outside；
The transport system includes conduit, and the conduit includes first passage, second channel, silk guide passage, the conduit
First end run through the mother bulb capsule and the bulbec capsule, the first passage connect with the bulbec capsule, the second channel
It is connect with the mother bulb capsule；
The drug stent system includes temperature sensitivity degradable liquid substance, the temperature sensitivity degradable liquid
Substance enters the inside of the mother bulb capsule from the second channel, and is oozed out to mother bulb capsule outside by the micropore,
Drug stent is formed on the outside of the mother bulb capsule.
Preferably, the second end of the conduit is provided with first pressure pump interface and second pressure pump interface, and described first
Pressure pump interface is connect with the first passage, and the second pressure pump interface is connect with the second channel.
Preferably, the conduit further includes third channel, and the third channel passes through for intravascular blood flow.
Preferably, the diameter of the first passage is less than the diameter of the second channel.
Preferably, the first passage is provided at least one liquid outlet with bulbec capsule junction.
Preferably, the second channel is provided at least one liquid outlet with mother bulb capsule junction.
Preferably, the temperature sensitivity degradable liquid substance is liquid mixture, and the liquid mixture is in temperature
It is in a liquid state when less than 20 DEG C, the liquid mixture is in solid-state when temperature is higher than 30 DEG C.
Preferably, the liquid mixture includes degradable liquid metal, inhibits cell cycle drug, anticoagulant.
Preferably, the liquid mixture further includes the endothelial cell of nanotechnology packaging.
Preferably, the conduit is composite conduit, is made of more conduits, the first passage, the second channel and institute
It is conduit to state silk guide passage, and the first passage, the second channel and the silk guide passage are fixedly connected.
The present invention is had the following technical effect that compared with prior art using above technical scheme：
The endovascular stent system of molding at once of the present invention, eliminating holder mesh does not have the shortcomings that medicine, and blood
Locally load concentration is low and uniform for tube wall, can reduce part and carry endothelialization delay caused by concentration height, it is dense to reduce topical remedy
The effect of degree unevenness causes is unstable；Degradable characteristic is suitble to treat repeatedly the patient of restenosis, it may be necessary to change cell
Period drug；It realizes flexible implantation, does not fear interlayer caused by surgical procedure：Since liquid squeezes out sacculus in blood vessel wall surface
Form hardening thing then can cover interlayer automatically as biological support；Operation is easy, and surgical procedure simplifies, and is not implanted into repeatedly
When need repeatedly replace stent system necessity, reduce operating time, reduce radiation exposure；It saves money, without post-processing ball
Capsule reduces number of holders, reduces surgery cost；It is suitble to the vascular treatment of Long lesion, bifurcated lesions and Small vessel is managed
Also there is good effect by upper, reduce restenosis probability；Technically having avoided medicinal balloon does not have support force, i.e. blood vessel bullet
Property retraction the problem of；Preferably resolve the endangium tearing and Problem of Interlayer that violence dilating sacculus is brought；Reduction can drop
The adherent bad problem of holder is solved, the breakage problem of BVS is not present, does not need OCT auxiliary, is not limited to non-complex coronary artery disease
Become, complex lesions can be extended to；For the CTO lesions easily perforated, which can have good vascular wall instant stopper to make
With reduction perforation risk is handled for high risk lesion.
Description of the drawings
Fig. 1 is the sectional view of the first embodiment of a preferred embodiment of the present invention.
Fig. 2 is the sectional view of second of embodiment of a preferred embodiment of the present invention.
Reference numeral therein is：Mother bulb capsule 1；Bulbec capsule 2；Conduit 3；First passage 4；Second channel 5；Silk guide passage 6；
Third channel 7；Micropore 8；Seal wire 9.
Specific implementation mode
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation describes, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, those of ordinary skill in the art obtained under the premise of not making creative work it is all its
His embodiment, shall fall within the protection scope of the present invention.
It should be noted that in the absence of conflict, the feature in embodiment and embodiment in the present invention can phase
Mutually combination.
The invention will be further described in the following with reference to the drawings and specific embodiments, but not as limiting to the invention.
The preferred embodiment of the present invention, as shown in Figure 1, a kind of being molded endovascular stent system, including ball at once
Bag system, transport system, drug stent system.
Balloon system includes primary and secondary sacculus, and primary and secondary sacculus includes mother bulb capsule 1 and bulbec capsule, and bulbec capsule is arranged in mother bulb capsule 1
Inside, the 1 coaxial setting of the axis collinear of the axis and mother bulb capsule 1 of bulbec capsule 2, i.e. bulbec capsule 2 and mother bulb capsule, the length of bulbec capsule 2
Degree is identical as the length of mother bulb capsule 1, and the diameter after bulbec capsule 2 expands is less than the diameter after mother bulb capsule 1 expands.
The axial direction of mother bulb capsule 1 and bulbec capsule 2 has a channel for running through 2 front-end and back-end of mother bulb capsule 1 and bulbec capsule, makes mother
Sacculus 1 and bulbec capsule 2 are in hollow form.
Specifically, bulbec capsule 2 expand after diameter and mother bulb capsule 1 expand after diameter difference range be 0.01mm~
3mm。
Mother bulb capsule 1 is compliant balloon or non-compliance sacculus, and bulbec capsule 2 is compliant balloon or non-compliance sacculus.
The surface surrounding of mother bulb capsule 1 is provided with equally distributed rows of micropore 8, and micropore 8 is one-way conduction hole, certain
It is connected under pressure, so that the substance inside mother bulb capsule 1 is passed through micropore 8 and flow to 1 outside of mother bulb capsule.
Micropore 8 can be in regularity distribution, can also be in that non-regularity is distributed.When micropore 8 is in regularity distribution, micropore
8 can linearly be distributed, and can also distribute as net shape.
Micropore 8 can be made of the ultrafiltration membrane of certain pore size.Using the ultrafiltration membrane with certain pore size, can make to mother bulb
Substance in capsule 1 is filtered so that under certain pressure effect, when the substance in mother bulb capsule 1 is flowed to outside mother bulb capsule 1, is kept away
Exempt from outside inert matter outflow mother bulb capsule 1.
Micropore 8 can also be provided with the micropore 8 for turning over platy structure, i.e. micropore 8 is filled by a plate substance, in a level pressure
Under the action of power, plate substance rotates, and opens micropore 8, so that the substance in mother bulb capsule 1 is passed through micropore 8 and flow to mother bulb capsule 1
Outside.
The pore size of micropore 8 is 0.01mm~1mm.
Balloon system further includes predilation sacculus, the axial tool of predilation sacculus there are one through predilation sacculus front end and
The channel of rear end.
Transport system includes conduit 3, and conduit 3 includes first passage 4, second channel 5, silk guide passage 6, first passage 4 with
Bulbec capsule 2 connects, and second channel 5 is connect with mother bulb capsule 1.
In the present invention, there are many ways of realization for conduit 3, wherein preferred, there are two types of embodiments.
The first embodiment is that conduit 3 is single catheter, and first passage 4, second channel 5, silk guide passage 6 are respectively provided with
Inside conduit 3.
Second of embodiment be：Conduit 3 is that more conduits are constituted, and first passage 4, second channel 5 and silk guide passage 6 are equal
For conduit, three conduits are fixedly connected by a variety of connection types.Such as continuously fixed using multiple fixing brackets, Gu
Fixed rack is rounded, and there are three holes for setting, are respectively used to first passage 4, second channel 5, silk guide passage 6 and pass through.
In a present embodiment, it is preferred that the first embodiment.
In the first embodiment, conduit 3 runs through mother bulb by the channel being arranged inside mother bulb capsule 1 and bulbec capsule 2
Capsule 1 and bulbec capsule 2, the i.e. first end of conduit 3 are through mother bulb capsule 1 and bulbec capsule 2 and expose.
The diameter range of conduit 3 is 0.5F~4F, i.e. 0.165mm~1.32mm.
The diameter of first passage 4 is less than the diameter of second channel 5.In the present embodiment, the diameter of first passage 4 and second
The ratio range of the diameter ratio in channel 5 is 1：1~1：10.
First passage 4 is connect with bulbec capsule 2, and junction is provided at least one liquid outlet, and liquid outlet is arranged in son
The middle part of sacculus 2.A diameter of 0.01mm~0.05mm of liquid outlet.
Second channel 5 is connect with mother bulb capsule 1, and junction is provided at least one liquid outlet, and liquid outlet is arranged in son
The outside of sacculus 2.A diameter of 0.01mm~0.05mm of liquid outlet.
Further, as shown in Fig. 2, conduit 3 further includes third channel 7, for when mother bulb capsule 1 is expanded, making blood
It is flowed by third channel 7, reduces the injury that bloodstream blocking generates.
The second end of conduit 3 is provided with first pressure pump interface and second pressure pump interface (not shown), the first pressure
Power pump interface is connect with first passage 4, and second pressure pump interface is connect with second channel 5, first pressure pump interface and a pressure
Pump connection, second pressure pump interface are connect with another compression pump.
Transport system further includes hypotube (not shown), and conduit 3 is arranged inside hypotube.
Drug stent system includes temperature sensitivity degradable liquid substance, and temperature sensitivity degradable substance is logical from second
Road 5 enters the inside of mother bulb capsule 1, and under pressure, is stretched from the inside of mother bulb capsule 1 to the outside of mother bulb capsule 1 by micropore 8
Go out, and drug stent is formed in 1 outside of mother bulb capsule.
Temperature sensitivity degradable liquid substance is in a liquid state based on degradable liquid metal in certain temperature range,
It is in solid-state in certain temperature range.
In the present embodiment, when temperature is less than 20 DEG C, temperature sensitivity degradable liquid substance is in a liquid state；When temperature height
When 30 DEG C, temperature sensitivity can boundary liquid substance be in solid-state, and in certain temperature with temperature increase coagulability reinforce.
In addition to degradable liquid metal, temperature sensitivity degradable liquid substance further includes inhibiting cell cycle drug and resisting
Solidifying drug.It includes the drugs such as sirolimus, rapamycin, Taxane family wherein to inhibit cell cycle drug, and these drugs
It is packed for lipid nanometer.Anticoagulant includes heparin, low molecular weight heparin etc..
Further, temperature sensitivity degradable liquid substance can also include the endothelial cell of nanotechnology packaging.
At once the application method of the molding endovascular stent system of the present embodiment is as follows：Seal wire 9 enters at vascular lesion；It will
Predilation sacculus is sent into along seal wire 9 at vascular lesion, and carries out predilation, and predilation pressure is larger；After the completion of predilation,
Predilation sacculus is withdrawn from, the primary and secondary sacculus slightly longer than predilation length of balloon is selected, the silk guide passage 6 of conduit 3 is directed at seal wire
9, so that primary and secondary sacculus is reached lesion along seal wire 9；Using compression pump by second pressure pump interface and second channel 5 to
Delivery temperature sensibility degradable liquid substance in mother bulb capsule 1 makes mother bulb capsule 1 expand；Diameter and blood after mother bulb capsule 1 is expanded
When the ratio between pipe diameter reaches 0.8~1, conveyed into bulbec capsule 2 by first pressure pump interface and first passage 4 using compression pump
Physiological saline and contrast agent mix reagent make bulbec capsule 2 expand；The expansion of bulbec capsule 2 makes the pressure inside mother bulb capsule 1 quickly increase
Add, when pressure increase to a certain extent when, temperature sensitivity degradable liquid substance is by the micropore 8 of mother bulb capsule 1 to mother bulb capsule
Outer 1 side exudation, is evenly distributed on the inner wall of lesion vessels, and under the action of body temperature, gradually solidifies, form drug branch
Frame；Effect after a certain period of time, first discharges the compression pump of bulbec capsule 2, then discharges the compression pump of mother bulb capsule 1, and primary and secondary sacculus is withdrawn from；
Or according to the state of an illness or operation needs, above-mentioned surgical procedure is repeated several times.
The foregoing is merely preferred embodiments of the present invention, are not intended to limit embodiments of the present invention and protection model
It encloses, to those skilled in the art, should can appreciate that all with made by description of the invention and diagramatic content
Equivalent replacement and obviously change obtained scheme, should all be included within the scope of the present invention.
Claims (10)
1. a kind of being molded endovascular stent system at once, which is characterized in that including balloon system, transport system, drug stent system
System；
The balloon system includes mother bulb capsule (1) and bulbec capsule (2), and bulbec capsule (2) setting is in the mother bulb capsule (1)
Portion, the axis collinear of the axis of the bulbec capsule (2) and the mother bulb capsule (1), the length and the bulbec of the mother bulb capsule (1)
The length of capsule (2) is identical, and the diameter of the bulbec capsule (2) after expansion is less than the diameter of the mother bulb capsule (1) after expansion；
The surface surrounding of the mother bulb capsule (1) is provided with equally distributed micropore (8), and the micropore (8) is one-way conduction hole, is used
Substance is conveyed from inside to outside in the mother bulb capsule (1)；
The transport system includes conduit (3), and the conduit (3) includes first passage (4), second channel (5), silk guide passage
(6), the first end of the conduit (3) run through the mother bulb capsule (1) and the bulbec capsule (2), the first passage (4) with it is described
Bulbec capsule (2) connects, and the second channel (5) connect with the mother bulb capsule (1)；
The drug stent system includes temperature sensitivity degradable liquid substance, the temperature sensitivity degradable liquid substance
Enter the inside of the mother bulb capsule (1) from the second channel (5), and by the micropore (8) on the outside of the mother bulb capsule (1)
Exudation forms drug stent on the outside of the mother bulb capsule (1).
2. according to claim 1 be molded endovascular stent system at once, which is characterized in that the second of the conduit (3)
End is provided with first pressure pump interface and second pressure pump interface, and the first pressure pump interface connects with the first passage (4)
It connects, the second pressure pump interface is connect with the second channel (5).
3. according to claim 1 be molded endovascular stent system at once, which is characterized in that the conduit (3) further includes
Third channel (7), the third channel (7) pass through for intravascular blood flow.
4. according to claim 1 be molded endovascular stent system at once, which is characterized in that the first passage (4)
Diameter is less than the diameter of the second channel (5).
5. it is according to claim 1 at once be molded endovascular stent system, which is characterized in that the first passage (4) with
Bulbec capsule (2) junction is provided at least one liquid outlet.
6. it is according to claim 1 at once be molded endovascular stent system, which is characterized in that the second channel (5) with
Mother bulb capsule (1) junction is provided at least one liquid outlet.
7. according to claim 1 be molded endovascular stent system at once, which is characterized in that the temperature sensitivity can drop
Solution liquid substance is liquid mixture, and the liquid mixture is in a liquid state when temperature is less than 20 DEG C, and the liquid mixture exists
Temperature is in solid-state when being higher than 30 DEG C.
8. according to claim 7 be molded endovascular stent system at once, which is characterized in that the liquid mixture includes
Degradable liquid metal inhibits cell cycle drug, anticoagulant.
9. according to claim 8 be molded endovascular stent system at once, which is characterized in that the liquid mixture also wraps
Include the endothelial cell of nanotechnology packaging.
10. according to claim 1 be molded endovascular stent system at once, which is characterized in that the conduit (3) is compound
Conduit is made of more conduits, and the first passage (4), the second channel (5) and the silk guide passage (6) are conduit, institute
First passage (4), the second channel (5) and the silk guide passage (6) is stated to be fixedly connected.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810312649.5A CN108703826A (en) | 2018-04-09 | 2018-04-09 | It is a kind of to be molded endovascular stent system at once |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810312649.5A CN108703826A (en) | 2018-04-09 | 2018-04-09 | It is a kind of to be molded endovascular stent system at once |
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| Publication Number | Publication Date |
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| CN108703826A true CN108703826A (en) | 2018-10-26 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN201810312649.5A Pending CN108703826A (en) | 2018-04-09 | 2018-04-09 | It is a kind of to be molded endovascular stent system at once |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109568771A (en) * | 2019-01-28 | 2019-04-05 | 山东省肿瘤防治研究院（山东省肿瘤医院） | A kind of alimentary canal double-layer seal formula balloon tube |
| CN114010917A (en) * | 2021-11-05 | 2022-02-08 | 广东博迈医疗科技股份有限公司 | Double-medicine administration balloon |
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Application publication date: 20181026 |