CN200951251Y - Double layered balloon catheter - Google Patents

Double layered balloon catheter Download PDF

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Publication number
CN200951251Y
CN200951251Y CN 200620040623 CN200620040623U CN200951251Y CN 200951251 Y CN200951251 Y CN 200951251Y CN 200620040623 CN200620040623 CN 200620040623 CN 200620040623 U CN200620040623 U CN 200620040623U CN 200951251 Y CN200951251 Y CN 200951251Y
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CN
China
Prior art keywords
sacculus
interior
shaft section
pipe
distal shaft
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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CN 200620040623
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Chinese (zh)
Inventor
李茂全
罗七一
石秀凤
张琳琳
张一�
杨海
葛泉波
吉美玲
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Microport Medical Shanghai Co Ltd
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Microport Medical Shanghai Co Ltd
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Priority to CN 200620040623 priority Critical patent/CN200951251Y/en
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Publication of CN200951251Y publication Critical patent/CN200951251Y/en
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Abstract

The utility model relates to a double layer balloon duct, which is characterized in that a balloon with a micropore connected with a single cavity is packed on the tube of the general balloon, which forms into a structure of a double layer balloon, tri-cavity tube, named double layer balloon duct. Wherein, the functions of the double layer are that the inner layer balloon can expand the vessel and the outer layer balloon made of unique micropore film can infiltrate and affect the therapy gene or medicine to vessels or target organs. The utility model can expand the narrow location of vessel and repair vascular endothelial simultaneously, inhibit hyperplasia of smooth muscle cell, avoid the coagulation of blood at the lesions locations as the double layer balloon duct is extracted immediately after operation, which greatly decreases the possibility of re-stenosis. Besides, the utility model decreases the operation cost, as diffuse lesions can be dealt in the same vessel only by a pipe.

Description

Double-layered balloon catheter
Technical field
This utility model relates to a kind of blood vessel internal shaping art instrument, specifically a kind of foley's tube, especially a kind of double-layered balloon catheter.
Background technology
Foley's tube is a kind of instrument of blood vessel internal shaping art.It is under the guiding of medical imaging device, with the percutaneous puncture technology foley's tube is inserted the narrow positions of blood vessel, carries out balloon expandable and expand under the strictness monitoring, makes the narrow positions of blood vessel obtain expansion, improves blood flow thereby recover lumen diameter.But, at postangioplasty the patient of 30-50% is arranged, because irregular vascular endothelial cell damage, cause tunica intima paraplasm, smooth muscle cell hyperplasia and make vascular restenosis.To this, metal rack and drug stent successively arise at the historic moment.Drug stent is to coat the medicine that can slowly discharge on the surface of metal rack, the hyperplasia that its purpose is to repair the endothelial injury of blood vessel and suppresses smooth muscle, and support is supported in the blood vessel for a long time, has fundamentally solved the problem of vascular restenosis after the plasty.It is a highly effective new technique of angiopathy, especially cardiovascular disease therapies in recent years.Blemish in an otherwise perfect thing be that for fear of the cohesion of blood on support internal layer surface, patient's blood vessel internal shaping postoperative of being expert at must be taken antiplatelet and anticoagulant medicine for a long time, and need place a plurality of drug stents to the blood vessel of diffuse lesion.The WO2005099804 patent has been introduced a kind of foley's tube of coating, and medicine is coated in the surface of sacculus, its objective is that sacculus delivers to diseased region with medicine in expansion in the narrow blood vessel, reaches the purpose that targeting is repaired damaged blood vessels.But, the shortcoming of medicine being delivered to pathological changes by balloon surface be sacculus return remove after, medicine is not washed away by blood flow immediately because of there being supporter, and the growth needs regular hour of endotheliocyte, want thoroughly to repair impaired blood vessel endothelium, must place the foley's tube of many coatings incessantly.This method not only bothers, and operating time is long, and same pathological changes is needed many conduit, increases patient's financial burden.
During the diffuse lesion vessels of this external treatment, if adopt the way of placing drug stent, not only operating difficulty is big to the pathological changes of this class, and needs the number of holders of placing many, causes expensive financial burden to the patient.
Summary of the invention
Technical problem to be solved in the utility model provides a kind of damage that not only can repair blood vessel endothelium in blood vessel dilating in the narrow positions, suppresses the hypertrophy of smooth muscle cell, and can treat the double-layered balloon catheter of diffuse lesion simultaneously, to overcome the Therapeutic Method trouble that prior art exists, operating time is long, and same pathological changes needed many conduit, increase patient's shortcomings such as financial burden.
The technical scheme of this utility model technical solution problem is as follows:
A kind of double-layered balloon catheter, its catheter body comprises a distal shaft section will and a distal shaft section, the near-end of described distal shaft section is connected with connecting device, the far-end of described distal shaft section will is provided with two sacculus---be installed with the outer sacculus of micropore on interior sacculus and the ball wall, the near-end of interior sacculus links to each other with the far-end of interior pipe, the near-end of outer sacculus links to each other with the far-end of outer tube, and the inside of interior sacculus is inserted with wire leading pipe, and the distal portion of interior sacculus and outer sacculus is connected with the distal seal of wire leading pipe in distal shaft section will; The inner chamber of wire leading pipe is a guidewire lumen, and its far-end is the inlet port of seal wire, and near-end is the outlet of seal wire; Between interior sacculus and the wire leading pipe, be fluid-through chamber between the outer wall of the inwall of interior pipe and wire leading pipe; Between interior sacculus and the outer sacculus, be injecting cavity between the outer wall of the inwall of outer tube and interior pipe, be positioned on the tube wall of wire leading pipe at sacculus position and be embedded with the development point.
Outer sacculus is partly or entirely made by the film that is installed with micropore.The material of film is medical macromolecular materials, on film, be installed with nanometer or micron-sized aperture, aperture and density are decided according to the gene of needs infiltrations or medicine, its effect is that a medicine that will play therapeutical effect is endosmosis on blood vessel wall by outer sacculus, and be blocked in the outer sacculus because of not passing aperture with other component that medicine is injected, improve the drug level of targeted therapy thus.Described gene or medicine can be synthetic drugs, also can form by taking from intravital certain component cultivation of patient.When for example needing to repair patient vessel's endothelium, can be expert at before the intervene operation separation in patient's body, extraction, inducing endothelial cell, cultivated and bred with medical approaches, vasopressing injection is in the double-layered balloon catheter injecting cavity then, be penetrated into by outer sacculus on patient's the damaged vessel walls, this patient's of taking from endotheliocyte is easy to growth on impaired blood vessel wall, do not have rejection, and blood vessel can be repaired fully.
Double-layered balloon catheter of the present utility model can be the quick exchange formula, also can be coaxial-type.
By guiding catheter and seal wire, double-layered balloon catheter is sent into diseased region during use, in fluid-through chamber, inject contrast solution, the full narrow blood vessel of internal layer balloon expandable; Meanwhile, outer sacculus is also expanded fully, and is close to blood vessel wall.The contrast solution of pumpback part then, reduce the pressure in the internal layer sacculus, make between internal layer sacculus and the outer sacculus and form the gap, inject gene or medicine with pressure injector in injecting cavity, gene or drug molecule that the outer sacculus that passes micropore will play therapeutical effect selectively are penetrated on the blood vessel wall.Can not injecting to repeated multiple times and pumpback gene or medicine under the prerequisite of blocking blood flow for a long time, till impaired blood vessel wall is repaired fully.The last remaining contrast solution of pumpback and gene or medicine are withdrawn from double-layered balloon catheter external, and treatment is promptly accused and finished.
This utility model is by covering the sacculus that one deck is installed with micropore outside common foley's tube (comprising one deck sacculus, a guidewire lumen, a fluid-through chamber), this sacculus connects its independent cavity, forms conduit---the double-layered balloon catheter that contains two-layer sacculus, three cavitys.The internal layer sacculus plays blood vessel dilating in the two-layer sacculus; Outer sacculus is made by the microporous membrane of uniqueness, can will play the gene of therapeutical effect or medicine by infiltration in the outer sacculus or affact on blood vessel wall, the target organ.Three cavitys are respectively the fluid-through chamber of guidewire lumen that the guiding seal wire passes, expansion internal layer sacculus and medicine or cell, gene are delivered to blood vessel wall and target organ by outer sacculus injecting cavity.This utility model can be repaired the damage of blood vessel endothelium in the narrow positions in blood vessel dilating, the hypertrophy that suppresses smooth muscle cell, the operation finish after this double-layered balloon catheter promptly withdraw from external, thereby avoided the cohesion of blood at diseased region, reduce the probability of restenosis to the utmost.Adopt double-layered balloon catheter of the present utility model in addition, a conduit just can solve the diffuse lesion of same blood vessel, reduces surgery cost greatly.
Description of drawings
Fig. 1 has shown the structural representation of quick exchange formula double-layered balloon catheter of the present utility model;
Fig. 2 has shown quick exchange formula double-layered balloon catheter of the present utility model sectional view longitudinally;
Fig. 3 is the A-A sectional view among Fig. 2, has shown the relative position relation of double-layered balloon and three cavitys;
Fig. 4 is the structure for amplifying sketch map of outer sacculus 2;
Fig. 5 has shown coaxial-type double-layered balloon catheter of the present utility model partial cross section figure longitudinally.
The specific embodiment
Below, will describe in more detail this utility model with reference to illustrated embodiment and accompanying drawing, it should be noted that these figure not strictness draw in proportion.Particularly show that for clear some sizes may be exaggerated or dwindle.Part corresponding or similar among the figure is usually with identical parameter symbolic representation.
As Fig. 1, Fig. 2 and shown in Figure 5, this utility model double-layered balloon catheter, its catheter body 20 comprises a distal shaft section will 21 and a distal shaft section 22, and the near-end of described distal shaft section 22 is connected with connecting device 6, is used in mode easily conduit being connected in expansion device.The far-end of described distal shaft section will 21 is provided with two sacculus---be installed with the outer sacculus 2 of micropore 16 on interior sacculus 1 and the ball wall, the near-end of interior sacculus 1 links to each other with the far-end of interior pipe 10, the near-end of outer sacculus 2 links to each other with the far-end of outer tube 9, the inside of interior sacculus 1 is inserted with wire leading pipe 11, and the distal portion of interior sacculus 1 and outer sacculus 2 is connected with the distal seal of wire leading pipe 11 in distal shaft section will 21; The inner chamber of wire leading pipe 11 is a guidewire lumen 3, and its far-end is the inlet port 7 of seal wire, and near-end is the outlet 12 of seal wire; Between interior sacculus 1 and the wire leading pipe 11, be fluid-through chamber 4 between the outer wall of the inwall of interior pipe 10 and wire leading pipe 11; Between interior sacculus 1 and the outer sacculus 2, be injecting cavity 5 between the outer wall of the inwall of outer tube 9 and interior pipe 10, be positioned on the tube wall of wire leading pipe 11 at sacculus position and be embedded with the point 8 that develops, the point 8 that develops is used for the accurate location of operation process conduit.The point 8 that develops can have one, is embedded the centre at sacculus inner guide wire pipe 11; The point 8 that develops also can have two, is embedded the far-end and the near-end of nearly sacculus in sacculus respectively.
As depicted in figs. 1 and 2, described double-layered balloon catheter is the quick exchange formula, the near-end of described wire leading pipe 11 stretches out from the outer tube 9 and interior pipe 10 tube walls of distal shaft section will proximal end, seal wire outlet 12 is arranged on the outer tube wall, the length of the length of wire leading pipe 11 and distal shaft section will 21 adapts, fluid-through chamber 4 extends to distal shaft section 22 near-ends from the inside of interior sacculus 1 always, communicates with an interface 14 of connecting device 6; Injecting cavity 5 extends to the near-end of distal shaft section 22 by the inside of outer sacculus 2, communicates with another interface 15 of connecting device 6, and described development point 8 has two, is embedded the far-end and the near-end of nearly sacculus in sacculus respectively.Pipe 17 and nearly interior pipe 13 in interior pipe 10 comprises far, pipe 17 and nearly interior pipe 13 communicate and are being tightly connected with wire leading pipe 11 intersections far, in just near pipe 13 with far away in pipe 17, wire leading pipe 11 carry out organic the combination intersecting parts with wire leading pipe 11, with the seriality of assurance fluid-through chamber 4.At distal shaft section 22 places, fluid-through chamber 4 is made of the inner chamber of pipe 13 near.Described nearly interior pipe 13 is a stainless steel tube.Between interior sacculus 1 and the outer sacculus 2, the inwall of outer tube 9 and far away between the outer wall of pipe 17, the inwall of outer tube 9 with near in to manage between 13 the outer wall be injecting cavity 5, injecting cavity 5 is extended to any position of distal shaft section 22 by distal shaft section will 21, be handled easily, present embodiment is preferably the near-end of distal shaft section 22, communicates with another interface 15 of connecting device 6.
The relative position of outer as seen from Figure 3 sacculus 2, interior sacculus 1 and wire leading pipe 11, and fluid-through chamber 4 that forms between them and injecting cavity 5, the inner chamber of wire leading pipe 11 is a guidewire lumen 3.
As seen from Figure 4: described outer sacculus 2 comprises the horn-like tapering 51,52 on a straight portion 53 and both sides; Straight portion 53 is seamless integral structures with tapering 51,52, or the branch body structure that connects in the mode of glue or laser weld.Described micropore 16 can be arranged on the straight portion 53, also can be arranged on the horn- like tapering 51 and 52 on both sides, also can all be provided with in the horn-like tapering 51 and 52 of straight portion 53 with both sides.
The material of outer sacculus 2 is medical macromolecular materials, as block copolymer PEBAX, polyethylene or the Merlon etc. of polyethers and polyamide.Nanometer that is installed with on the sacculus 2 or micron-sized micropore 16 outside, aperture and density thereof decide according to the gene of needs infiltration or medicine, and for example when the medicine that needs infiltration was endotheliocyte, preferably the aperture was 6~15 μ m, one-tenth porosity 5~60%.This micropore 16 can be made by laser boring or etching technique.
During actual the use, seal wire penetrates guidewire lumen 3 from the distal guide wire import 7 of double-layered balloon catheter 20, and passes from seal wire outlet 12.Double-layered balloon catheter 20 arrives the narrow positions of blood vessel along this seal wire.Contrast solution injects fluid-through chamber 4 by the interface 14 of connecting device 6, under the certain pressure interior sacculus 1 is expanded to about nominal diameter, and outer sacculus 2 is also expanded simultaneously, and is close to the inwall of lesion vessels.Pumpback part contrast solution, the pressure in reducing in the sacculus 1, the diameter of interior sacculus 1 also reduces thereupon, and outer sacculus 2 then is not affected, and the injecting cavity 5 in this moment between sacculus 1 and the outer sacculus 2 keeps certain volume.Medicine injects injecting cavity 5 by the interface 15 of connecting device 6, arrives in the outer sacculus 2, and is penetrated on the blood vessel wall by the micropore 16 on the outer sacculus 2.Kept in the injecting cavity 5 pressure about 3~5 minutes, the pumpback injection, injectable drug in injecting cavity 5 once more after about 3~5 minutes keeps pumpback medicine after 3~5 minutes, so repeatedly, till impaired blood vessel wall is repaired fully.To diffuse lesion vessels, can utilize same double-layered balloon catheter to treat piecemeal.
As shown in Figure 5, described double-layered balloon catheter is a coaxial-type, and the near-end of described wire leading pipe 11 is in the near-end of distal shaft section 22, communicates with an interface 18 of connecting device 6 '; Fluid-through chamber 4 extends to distal shaft section 22 near-ends from the inside of interior sacculus 1 always, communicates with an interface 14 of connecting device 6 '; Injecting cavity 5 extends to the near-end of distal shaft section 22 by distal shaft section will 21, communicates with another interface 15 of connecting device 6 '.
During actual the use, seal wire penetrates guidewire lumen 3 from the far-end 7 of double-layered balloon catheter 20, and passes from the interface 18 of connecting device 6 '.Double-layered balloon catheter 20 arrives the narrow positions of blood vessel along this seal wire.Contrast solution injects fluid-through chamber 4 by the interface 14 of connecting device 6 ', under the certain pressure interior sacculus 1 is expanded to about nominal diameter, and outer sacculus 2 is also expanded simultaneously, and is close to the inwall of lesion vessels.Pumpback part contrast solution, the pressure in reducing in the sacculus 1, the diameter of interior sacculus 1 also reduces thereupon, and outer sacculus 2 then is not affected, and the injecting cavity 5 in this moment between sacculus 1 and the outer sacculus 2 keeps certain volume.Medicine injects injecting cavity 5 by the interface 15 of connecting device 6 ', arrives in the outer sacculus 2, and is penetrated on the blood vessel wall by the micropore 16 on the outer sacculus 2.Kept in the injecting cavity 5 pressure about 3~5 minutes, the pumpback injection, injectable drug in injecting cavity 5 once more after about 3~5 minutes keeps pumpback medicine after 3~5 minutes, so repeatedly, till impaired blood vessel wall is repaired fully.To diffuse lesion vessels, can utilize same double-layered balloon catheter to treat piecemeal.

Claims (9)

1. a double-layered balloon catheter (20), its catheter body comprises a distal shaft section will (21) and a distal shaft section (22), the near-end of described distal shaft section (22) is connected with connecting device (6), it is characterized in that, the far-end of described distal shaft section will (21) is provided with two sacculus---be installed with the outer sacculus (2) of micropore (16) on interior sacculus (1) and the ball wall, the near-end of interior sacculus (1) links to each other with the far-end of interior pipe (10), the near-end of outer sacculus (2) links to each other with the far-end of outer tube (9), the inside of interior sacculus (1) is inserted with wire leading pipe (11), and the distal portion of interior sacculus (1) and outer sacculus (2) is connected with the distal seal of wire leading pipe (11) in distal shaft section will (21); The inner chamber of wire leading pipe (11) is guidewire lumen (3), and its far-end is the inlet port (7) of seal wire, and near-end is the outlet (12) of seal wire; Between interior sacculus (1) and the wire leading pipe (11), be fluid-through chamber (4) between the outer wall of the inwall of interior pipe (10) and wire leading pipe (11); Between interior sacculus (1) and the outer sacculus (2), be injecting cavity (5) between the outer wall of the inwall of outer tube (9) and interior pipe (10), be positioned on the tube wall of wire leading pipe (11) at sacculus position and be embedded with development point (8).
2. double-layered balloon catheter according to claim 1, it is characterized in that, described double-layered balloon catheter is the quick exchange formula, the near-end of described wire leading pipe (11) stretches out from the outer tube (9) and interior pipe (10) tube wall of distal shaft section will proximal end, seal wire outlet (12) is arranged on the outer tube wall, the length of the length of wire leading pipe (11) and distal shaft section will (21) adapts, fluid-through chamber (4) extends to distal shaft section (22) near-end always from the inside of interior sacculus (1), communicate with an interface (14) of connecting device (6); Injecting cavity (5) extends to the near-end of distal shaft section (22) by the inside of outer sacculus (2), communicates with another interface (15) of connecting device (6).
3. double-layered balloon catheter according to claim 2, it is characterized in that, interior manage (10) comprise far interior pipe (17) and closely interior manage (13), pipe (17) and nearly interior pipe (13) communicate and are being tightly connected with wire leading pipe (11) intersection in far away, locate in distal shaft section (22), fluid-through chamber (4) is made of the inner chamber of pipe (13) near.
4. double-layered balloon catheter according to claim 3 is characterized in that, described nearly interior pipe (13) is a stainless steel tube.
5. double-layered balloon catheter according to claim 1 is characterized in that described double-layered balloon catheter is a coaxial-type, and the near-end of described wire leading pipe (11) is in the near-end of distal shaft section (22), communicates with an interface (18) of connecting device (6 '); Fluid-through chamber (4) extends to distal shaft section (22) near-end always from the inside of interior sacculus (1), communicate with an interface (14) of connecting device (6 '); Injecting cavity (5) extends to the near-end of distal shaft section (22) by distal shaft section will (21), communicates with another interface (15) of connecting device (6 ').
6. double-layered balloon catheter according to claim 1 is characterized in that, described development point (8) has one, is embedded the centre at sacculus inner guide wire pipe (11); Or two, be embedded in sacculus the far-end and the near-end of nearly sacculus respectively.
7. double-layered balloon catheter according to claim 1 is characterized in that, described outer sacculus (2) comprises horn-like tapering (51), (52) on a straight portion (53) and both sides; Straight portion (53) and tapering (51) and (52) are seamless integral structures, or the branch body structure that connects in the mode of glue or laser weld.
8. double-layered balloon catheter according to claim 7, it is characterized in that, described micropore (16) is arranged on the straight portion (53), or is arranged on the horn-like tapering (51) and (52) on both sides, or is arranged on the horn-like tapering (51) and (52) on straight portion (53) and both sides.
9. according to claim 1 or 8 described double-layered balloon catheters, it is characterized in that the aperture of described micropore (16) is 6~15 μ m, become porosity 5~60%.
CN 200620040623 2006-03-29 2006-03-29 Double layered balloon catheter Expired - Lifetime CN200951251Y (en)

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Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102258825A (en) * 2010-05-28 2011-11-30 微创医疗器械(上海)有限公司 Percutaneous transluminal coronary angioplasty (PTCA) balloon catheter
CN103027750A (en) * 2012-11-23 2013-04-10 刘宗军 Electrical ablation balloon radiofrequency catheter in percutaneous renal artery
CN103239795A (en) * 2013-05-13 2013-08-14 上海凯利泰医疗科技股份有限公司 Guide-wire-free bending controllable balloon catheter device and use method thereof
CN108703826A (en) * 2018-04-09 2018-10-26 复旦大学附属华山医院 It is a kind of to be molded endovascular stent system at once
CN108837283A (en) * 2018-04-12 2018-11-20 上海市东方医院 Stem bronchi cell precise positioning slow-released system
CN109091746A (en) * 2018-10-10 2018-12-28 上海康德莱医疗器械股份有限公司 A kind of infusion of medicine foley's tube
CN109171833A (en) * 2018-09-21 2019-01-11 王铁功 A kind of closure of blood flow freeze mode double side walls sacculus, foley's tube
CN112516438A (en) * 2020-12-03 2021-03-19 广东博迈医疗器械有限公司 Double-acting balloon catheter
CN112770790A (en) * 2018-08-03 2021-05-07 奈克塞罗医学有限公司 Purified pentagalloylglucose and delivery device
WO2021217697A1 (en) * 2020-04-29 2021-11-04 童妍(上海)医疗器械有限公司 Drug-release balloon catheter and drug release method therefor

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102258825A (en) * 2010-05-28 2011-11-30 微创医疗器械(上海)有限公司 Percutaneous transluminal coronary angioplasty (PTCA) balloon catheter
CN102258825B (en) * 2010-05-28 2014-09-10 上海微创医疗器械(集团)有限公司 Balloon catheter
CN103027750A (en) * 2012-11-23 2013-04-10 刘宗军 Electrical ablation balloon radiofrequency catheter in percutaneous renal artery
CN103027750B (en) * 2012-11-23 2015-02-11 刘宗军 Electrical ablation balloon radiofrequency catheter in percutaneous renal artery
CN103239795A (en) * 2013-05-13 2013-08-14 上海凯利泰医疗科技股份有限公司 Guide-wire-free bending controllable balloon catheter device and use method thereof
CN108703826A (en) * 2018-04-09 2018-10-26 复旦大学附属华山医院 It is a kind of to be molded endovascular stent system at once
CN108837283A (en) * 2018-04-12 2018-11-20 上海市东方医院 Stem bronchi cell precise positioning slow-released system
CN112770790A (en) * 2018-08-03 2021-05-07 奈克塞罗医学有限公司 Purified pentagalloylglucose and delivery device
US11331102B2 (en) 2018-08-03 2022-05-17 Nectero Medical, Inc. Purified pentagalloyl glucose and devices for delivery
CN109171833A (en) * 2018-09-21 2019-01-11 王铁功 A kind of closure of blood flow freeze mode double side walls sacculus, foley's tube
CN109091746A (en) * 2018-10-10 2018-12-28 上海康德莱医疗器械股份有限公司 A kind of infusion of medicine foley's tube
WO2021217697A1 (en) * 2020-04-29 2021-11-04 童妍(上海)医疗器械有限公司 Drug-release balloon catheter and drug release method therefor
CN112516438A (en) * 2020-12-03 2021-03-19 广东博迈医疗器械有限公司 Double-acting balloon catheter

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