CN104474376A - Traditional Chinese medicine capsules for treating colorectal cancer and preparation method of traditional Chinese medicine capsules - Google Patents
Traditional Chinese medicine capsules for treating colorectal cancer and preparation method of traditional Chinese medicine capsules Download PDFInfo
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Abstract
The invention discloses traditional Chinese medicine capsules for treating colorectal cancer. The traditional Chinese medicine capsules are prepared from the following medicinal materials in parts by weight: 10 parts of sophora flower, 10 parts of gynostemma pentaphylla, 10 parts of lotus pollen, 10 parts of scutellaria baicalensis, 10 parts of spirulina platensis, 20 parts of semen lepidii sativi, 30 parts of patrinia, 30 parts of purslane, 30 parts of raw coix seed, 15 parts of radix sophorae flavescentis, 10 parts of wild chilli, and 10 parts of fructus trichosanthis. A preparation method comprises the following steps: weighing the medicinal materials and placing the medicinal materials in a container, adding 8 times amount of water, decocting for 1.5 hours and filtering; adding 6 times amount of water in the filter residue, decocting for 1 hour and filtering; combining the filtrates, concentrating, drying, and filling in capsule shells. Clinical experiments prove that the traditional Chinese medicine capsules disclosed by the invention have the remarkable effect of improving colorectal cancer prognosis by selecting the proper medicinal materials and proportioning ratios, as well as are safe and free from toxic and side effects.
Description
Technical field
The present invention relates to a kind of Chinese medicine, be specifically related to a kind of Chinese medicinal capsule being used for the treatment of colorectal cancer and preparation method thereof.
Background technology
Colorectal cancer is one of modal digestive tract tumor, multidisciplinary synthesis treatment is advocated in its treatment at present, main method has operation, chemotherapy, radiotherapy, Biotherapeutics and Chinese medicine, and Chinese medicine has unique important effect in the multidisciplinary synthesis therapy system of colorectal cancer.The effective medicine of generally recognized as safe is still lacked at present for treatment colorectal cancer.
Summary of the invention
The present invention aims to provide a kind of Chinese medicinal capsule being used for the treatment of colorectal cancer and preparation method thereof, by selecting suitable medical material and proportioning thereof, reaches the remarkable efficacy contributing to PATIENTS WITH LARGE BOWEL rehabilitation, and safe without toxic side effect.
In order to achieve the above object, the present invention is by the following technical solutions: a kind of Chinese medicinal capsule being used for the treatment of colorectal cancer, is prepared from by the medical material of following weight proportion: 8 ~ 10 parts, Flos Sophorae, Herb Gynostemmae Pentaphylli 8 ~ 10 parts, Flos Nelumbinis pollen 8 ~ 10 parts, Radix Scutellariae 8 ~ 10 parts, special crisp spy pull youngster 8 ~ 10 parts, colza 16 ~ 20 parts of walking alone, Herba Patriniae 25 ~ 30 parts, Herba Portulacae 25 ~ 30 parts, Semen Coicis 25 ~ 30 parts, Radix Sophorae Flavescentis 12 ~ 15 parts, wild Fructus Capsici 0 ~ 10 part, Fructus Trichosanthis 0 ~ 10 part.
As preferably, be prepared from by the medical material of following weight proportion: 10 parts, Flos Sophorae, Herb Gynostemmae Pentaphylli 10 parts, Flos Nelumbinis pollen 10 parts, Radix Scutellariae 10 parts, special crisp spy pull youngster 10 parts, colza 20 parts of walking alone, Herba Patriniae 30 parts, Herba Portulacae 30 parts, Semen Coicis 30 parts, Radix Sophorae Flavescentis 15 parts.
As preferably, be prepared from by the medical material of following weight proportion: 10 parts, Flos Sophorae, Herb Gynostemmae Pentaphylli 10 parts, Flos Nelumbinis pollen 10 parts, Radix Scutellariae 10 parts, special crisp spy pull youngster 10 parts, colza 20 parts of walking alone, Herba Patriniae 30 parts, Herba Portulacae 30 parts, Semen Coicis 30 parts, Radix Sophorae Flavescentis 15 parts, Fructus Trichosanthis 10 parts.
As preferably, be prepared from by the medical material of following weight proportion: 10 parts, Flos Sophorae, Herb Gynostemmae Pentaphylli 10 parts, Flos Nelumbinis pollen 10 parts, Radix Scutellariae 10 parts, special crisp spy pull youngster 10 parts, colza 20 parts of walking alone, Herba Patriniae 30 parts, Herba Portulacae 30 parts, Semen Coicis 30 parts, Radix Sophorae Flavescentis 15 parts, wild Fructus Capsici 10 parts.
As preferably, be prepared from by the medical material of following weight proportion: 10 parts, Flos Sophorae, Herb Gynostemmae Pentaphylli 10 parts, Flos Nelumbinis pollen 10 parts, Radix Scutellariae 10 parts, special crisp spy pull youngster 10 parts, colza 20 parts of walking alone, Herba Patriniae 30 parts, Herba Portulacae 30 parts, Semen Coicis 30 parts, Radix Sophorae Flavescentis 15 parts, wild Fructus Capsici 10 parts, Fructus Trichosanthis 10 parts.
A kind of preparation method being used for the treatment of the Chinese medicinal capsule of colorectal cancer, comprise the steps: that Flos Sophorae, Herb Gynostemmae Pentaphylli, Radix Scutellariae, colza of walking alone, Herba Patriniae, Herba Portulacae, Semen Coicis, Radix Sophorae Flavescentis, wild Fructus Capsici, Fructus Trichosanthis are put into container by (1), add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate for subsequent use; (2) crisp for spy spy is pulled youngster's pulverization and put into container, add Flos Nelumbinis pollen, and add a small amount of Mel, stir, through seal of vessel, water proof heating 15 ~ 25min, takes out, obtains mastic for subsequent use; (3) by the filtrate obtained by above-mentioned steps (1) ~ (2) and mastic mixing, utilize modern advanced pharmacy science and technology, make capsule, obtain Chinese medicine preparation of the present invention.
The pharmacology analysis of each Chinese medicinal ingredients of the present invention is as follows:
Flos Sophorae [source] this product is the dry flower and alabastrum of leguminous plant Chinese scholartree.[nature and flavor] are bitter, are slightly cold.[return through] returns liver, large intestine channel.[function cures mainly] cooling blood for hemostasis, purging liver-fire.For having blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, spit blood, epistaxis, liver-heat conjunctival congestion, has a headache dizzy.
Herb Gynostemmae Pentaphylli [source] medical material Ji Yuan: be the herb of cucurbitaceous plant Herb Gynostemmae Pentaphylli.[nature and flavor] bitter in the mouth; Micro-sweet; Cool in nature.[return through] returns lung; Spleen; Kidney channel.[function cures mainly] heat clearing away; Tonify deficiency; Removing toxic substances.Main body void is weak; Nephrasthenia emission; Leukopenia; Hyperlipemia; Viral hepatitis; Chronic gastroenteritis; Chronic tracheitis.
Flos Nelumbinis pollen [function cures mainly] tranquilizing by nourishing the heart, hemostasis with astringents, controlling nocturnal emission with astringent drugs benefit essence, detoxicating intestine.
The dry root of Radix Scutellariae [source] labiate Radix Scutellariae.[function cures mainly] heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.
Special crisp spy pulls [source] medical material Ji Yuan: be the frond of the multiple spirulinas such as Oscillariaceae plant spirulina plalensis.[function cures mainly] alleviates the toxicity of cancer radiation, chemotherapy; Improve immunologic function; Reduce blood fat.The auxiliary treatment of main cancer; Hyperlipemia; Iron deficiency anemia; Diabetes; Malnutrition; Body is empty after being ill; As health food.
To walk alone the dry mature seed of colza [source] crucifer lepidium apetalum Willd.[nature and flavor] secondary is xeothermic, acrid in the mouth.[function cures mainly] raw dry heat-dissipating, replenishing essence, controlling nocturnal emission with astringent drugs, tonifying YANG, lactogenic, vision enhancing, antiinflammatory detumescent.Cure mainly raw property or lymphatic temperament disease, as seminal fluid is rare, seminal emission, premature ejaculation, positive disease, hypogalactia, visual deterioration, various inflammation swells.
Herba Patriniae [nature and flavor] is pungent, bitter, cool.[return through] enters stomach, large intestine, Liver Channel.[function cures mainly] heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, blood circulation promoting competent silt.For acute appendicitis, lung abscess and sore and toxic, the stagnant caused breast abdomen pain of the excess-heat stasis of blood, the diseases such as the stagnant stomachache of the stasis of blood in puerperal.
Herba Portulacae [source] this product is portulacaceous plant Herba Portulacae, with all herbal medicine.[nature and flavor] acid, cold.[function cures mainly] clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.For bacillary dysentery, acute gastroenteritis, acute appendicitis, mastitis, bleeding hemorrhoids, leucorrhea; Furuncle swelling toxin is controlled in external, eczema, herpes zoster.
The kernel that Semen Coicis [source] is grass Semen Coicis.[nature and flavor] are sweet; Light; Be slightly cold.[return through] spleen; Lung; Kidney channel.The spleen invigorating of [function cures mainly] dampness removing; Arthralgia relieving by relaxing muscles and tendons; Clearing away heat and discharging pus.Main edema; Foot gas; Dribbling urination; Damp-warm diseases; To have loose bowels leukorrhagia; Rheumatic arthralgia; The contracture of muscle arteries and veins; Lung abscess; Intestinal carbuncle; Verruca plana.
Radix Sophorae Flavescentis [source] this product is the dry root of leguminous plant Radix Sophorae Flavescentis.[nature and flavor] are bitter, cold.[return through] GUIXIN, liver, stomach, large intestine, urinary bladder channel.[function cures mainly] heat clearing and damp drying, parasite killing, diuresis.For hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy.
Wild Fructus Capsici [source] is Solanaceae nightshade Herba Solani Nigri, with all herbal medicine.[nature and flavor] are bitter, cold.Slightly poisonous.[function cures mainly] heat-clearing and toxic substances removing, inducing diuresis to remove edema.For cat fever, toothache, chronic bronchitis, dysentery, urinary system infection, mastitis, leucorrhea, cancer; Carbuncle furuncle furuncle is controlled in external, pemphigus, venom.
Fructus Trichosanthis [source] medical material Ji Yuan: be the fruit of cucurbitaceous plant Fructus Trichosanthis.[nature and flavor] sweet in the mouth; Micro-hardship; Cold in nature.[return through] returns lung; Stomach; Large intestine channel.[function cures mainly] removing heat-phlegm; Wide born of the same parents' eliminating stagnation; Moisturize laxation.Main cough due to lung-heat; The thoracic obstruction; Quench one's thirst; Constipation; Carbuncle sore tumefacting virus.
The present invention compared with prior art, has following beneficial effect:
1, Chinese medicine preparation of the present invention for treatment colorectal cancer cure rate high and safe without toxic side effect, and can related complication be prevented.Between formula medical material, compatibility is rigorous, the synergistic function produced after not only making full use of compatibility of drugs, and avoid pharmaceutically-active mutual Hangzhoupro short of money and offset or slacken original effect, more note selecting the compatibility of drugs application that can alleviate or eliminate the strong of medicine or toxic and side effects, firmly avoid the mutual compatibility of medicine and produce toxic reaction or strong side effect.By scientific compatibility, not only complicated in the state of an illness, when fast changing, the present invention can not only effectively organize and implement reasonable treatment, make it reach medicine to remove to disease, and for prevent disease progress, in invade internal organs also have good preventive effect, very valuable on clinical application.
2, Chinese medicine preparation of the present invention selects high-quality Chinese crude drug to make, and selected medical material compatibility is suitable, meets Chinese medicine and modern medicine study theory, and utilize modern medicine pharmaceutical technology to make, safe without toxic side effect, reach the object for the treatment of both the principal and secondary aspects of a disease, clinic is applied.
Detailed description of the invention
In order to understand better and implement the present invention, further illustrate the present invention below in conjunction with specific embodiment.
Embodiment 1
Take: 10 grams, Flos Sophorae, Herb Gynostemmae Pentaphylli 10 grams, Flos Nelumbinis pollen 10 grams, Radix Scutellariae 10 grams, special crisp spy pull youngster 10 grams, colza 20 grams of walking alone, Herba Patriniae 30 grams, Herba Portulacae 30 grams, Semen Coicis 30 grams, Radix Sophorae Flavescentis 15 grams, wild Fructus Capsici 10 grams, Fructus Trichosanthis 10 grams.As follows: Flos Sophorae, Herb Gynostemmae Pentaphylli, Radix Scutellariae, colza of walking alone, Herba Patriniae, Herba Portulacae, Semen Coicis, Radix Sophorae Flavescentis, wild Fructus Capsici, Fructus Trichosanthis are put into container by (1), add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate for subsequent use; (2) crisp for spy spy is pulled youngster's pulverization and put into container, add Flos Nelumbinis pollen, and add a small amount of Mel, stir, through seal of vessel, water proof heating 15 ~ 25min, takes out, obtains mastic for subsequent use; (3) by the filtrate obtained by above-mentioned steps (1) ~ (2) and mastic mixing, utilize modern advanced pharmacy science and technology, make capsule, obtain Chinese medicine preparation of the present invention.
Usage and dosage: oral, every day 2 times, each 1 time sooner or later, each 1, warm water delivery service after meal.
Embodiment 2
Take: 10 grams, Flos Sophorae, Herb Gynostemmae Pentaphylli 10 grams, Flos Nelumbinis pollen 10 grams, Radix Scutellariae 10 grams, special crisp spy pull youngster 10 grams, colza 20 grams of walking alone, Herba Patriniae 30 grams, Herba Portulacae 30 grams, Semen Coicis 30 grams, Radix Sophorae Flavescentis 15 grams, wild Fructus Capsici 10 grams, Fructus Trichosanthis 10 grams.
Preparation method, the usage and dosage of the present embodiment are identical with embodiment 1.
Embodiment 3
Take: 10 grams, Flos Sophorae, Herb Gynostemmae Pentaphylli 10 grams, Flos Nelumbinis pollen 10 grams, Radix Scutellariae 10 grams, special crisp spy pull youngster 10 grams, colza 20 grams of walking alone, Herba Patriniae 30 grams, Herba Portulacae 30 grams, Semen Coicis 30 grams, Radix Sophorae Flavescentis 15 grams, wild Fructus Capsici 10 grams, Fructus Trichosanthis 10 grams.
Preparation method, the usage and dosage of the present embodiment are identical with embodiment 1.
Clinical data:
1, case selection:
Selected the routine clinical observation of PATIENTS WITH LARGE BOWEL 108 in my institute's diagnosis and treatment since 2013, clinical symptoms all meets standard listed by colorectal cancer.Patient is divided into treatment group and matched group two groups at random, treatment group 54 example, matched group 54 example.The course of disease, the degrees of symptoms for the treatment of group and matched group two groups of cases are basically identical, without significant difference, have comparability.
2, medicament selection:
Treatment group takes the Chinese medicinal capsule preparation obtained by the embodiment of the present invention 1, oral, every day 2 times, each 1 time sooner or later, each 1, warm water delivery service after meal; Within 30 days, be 1 course for the treatment of, take 1 ~ 3 course for the treatment of continuously.
Matched group adopts conventional western medicine Comprehensive Treatment, the course for the treatment of same treatment group.
3 courses for the treatment of are treated in continuous smelting, contrast two groups of curative effects.
3, efficacy determination:
(1) cure: Clinical symptom and sign disappears completely, lab testing value recovers normal.
(2) take a turn for the better: clinical symptoms is clearly better, lab testing value comparatively treats precursor to normally.
(3) do not heal: clinical symptoms is without improvement, and lab testing value nothing compared with before treatment takes a turn for the better.
4, result:
Select in the treatment group of the embodiment of the present invention 1 Chinese medicinal capsule, cure 1 example, take a turn for the better 38 examples, and do not heal 15 examples, cure rate 1.8%, total effective rate 72.2%.
Cure 0 example in matched group, take a turn for the better 14 examples, and do not heal 40 examples, cure rate 0%, total effective rate 25.9%.Laggard line trace in 6 months is followed up a case by regular visits to, and has 1 example recurrence.
Above result display, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.
Obviously, the above embodiment of the present invention is only for example of the present invention is clearly described, and is not the restriction to embodiments of the present invention.For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description.Here cannot give exhaustive to all embodiments.Every belong to technical scheme of the present invention the apparent change of extending out or variation be still in the row of protection scope of the present invention.
Claims (6)
1. one kind is used for the treatment of the Chinese medicinal capsule of colorectal cancer, it is characterized in that, be prepared from by the medical material of following weight proportion: 8 ~ 10 parts, Flos Sophorae, Herb Gynostemmae Pentaphylli 8 ~ 10 parts, Flos Nelumbinis pollen 8 ~ 10 parts, Radix Scutellariae 8 ~ 10 parts, special crisp spy pull youngster 8 ~ 10 parts, colza 16 ~ 20 parts of walking alone, Herba Patriniae 25 ~ 30 parts, Herba Portulacae 25 ~ 30 parts, Semen Coicis 25 ~ 30 parts, Radix Sophorae Flavescentis 12 ~ 15 parts, wild Fructus Capsici 0 ~ 10 part, Fructus Trichosanthis 0 ~ 10 part.
2. a kind of Chinese medicinal capsule being used for the treatment of colorectal cancer according to claim 1, it is characterized in that, be prepared from by the medical material of following weight proportion: 10 parts, Flos Sophorae, Herb Gynostemmae Pentaphylli 10 parts, Flos Nelumbinis pollen 10 parts, Radix Scutellariae 10 parts, special crisp spy pull youngster 10 parts, colza 20 parts of walking alone, Herba Patriniae 30 parts, Herba Portulacae 30 parts, Semen Coicis 30 parts, Radix Sophorae Flavescentis 15 parts.
3. a kind of Chinese medicinal capsule being used for the treatment of colorectal cancer according to claim 1, it is characterized in that, be prepared from by the medical material of following weight proportion: 10 parts, Flos Sophorae, Herb Gynostemmae Pentaphylli 10 parts, Flos Nelumbinis pollen 10 parts, Radix Scutellariae 10 parts, special crisp spy pull youngster 10 parts, colza 20 parts of walking alone, Herba Patriniae 30 parts, Herba Portulacae 30 parts, Semen Coicis 30 parts, Radix Sophorae Flavescentis 15 parts, Fructus Trichosanthis 10 parts.
4. a kind of Chinese medicinal capsule being used for the treatment of colorectal cancer according to claim 1, it is characterized in that, be prepared from by the medical material of following weight proportion: 10 parts, Flos Sophorae, Herb Gynostemmae Pentaphylli 10 parts, Flos Nelumbinis pollen 10 parts, Radix Scutellariae 10 parts, special crisp spy pull youngster 10 parts, colza 20 parts of walking alone, Herba Patriniae 30 parts, Herba Portulacae 30 parts, Semen Coicis 30 parts, Radix Sophorae Flavescentis 15 parts, wild Fructus Capsici 10 parts.
5. a kind of Chinese medicinal capsule being used for the treatment of colorectal cancer according to claim 1, it is characterized in that, be prepared from by the medical material of following weight proportion: 10 parts, Flos Sophorae, Herb Gynostemmae Pentaphylli 10 parts, Flos Nelumbinis pollen 10 parts, Radix Scutellariae 10 parts, special crisp spy pull youngster 10 parts, colza 20 parts of walking alone, Herba Patriniae 30 parts, Herba Portulacae 30 parts, Semen Coicis 30 parts, Radix Sophorae Flavescentis 15 parts, wild Fructus Capsici 10 parts, Fructus Trichosanthis 10 parts.
6. one kind is used for the treatment of the preparation method of the Chinese medicinal capsule of colorectal cancer, it is characterized in that, comprise the steps: that Flos Sophorae, Herb Gynostemmae Pentaphylli, Radix Scutellariae, colza of walking alone, Herba Patriniae, Herba Portulacae, Semen Coicis, Radix Sophorae Flavescentis, wild Fructus Capsici, Fructus Trichosanthis are put into container by (1), add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate for subsequent use; (2) crisp for spy spy is pulled youngster's pulverization and put into container, add Flos Nelumbinis pollen, and add a small amount of Mel, stir, through seal of vessel, water proof heating 15 ~ 25min, takes out, obtains mastic for subsequent use; (3) by the filtrate obtained by above-mentioned steps (1) ~ (2) and mastic mixing, utilize modern advanced pharmacy science and technology, make capsule, obtain Chinese medicine preparation of the present invention.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410792643.4A CN104474376A (en) | 2014-12-19 | 2014-12-19 | Traditional Chinese medicine capsules for treating colorectal cancer and preparation method of traditional Chinese medicine capsules |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410792643.4A CN104474376A (en) | 2014-12-19 | 2014-12-19 | Traditional Chinese medicine capsules for treating colorectal cancer and preparation method of traditional Chinese medicine capsules |
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Citations (2)
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| WO2005095463A1 (en) * | 2004-03-26 | 2005-10-13 | Glycogenesys, Inc. | Modified pectins, compositions and methods related thereto |
| CN104027666A (en) * | 2014-06-12 | 2014-09-10 | 纪英 | Traditional Chinese medicine (TCM) for treating colon cancer and preparation method thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005095463A1 (en) * | 2004-03-26 | 2005-10-13 | Glycogenesys, Inc. | Modified pectins, compositions and methods related thereto |
| CN104027666A (en) * | 2014-06-12 | 2014-09-10 | 纪英 | Traditional Chinese medicine (TCM) for treating colon cancer and preparation method thereof |
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| Title |
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| 南京中医药大学: "《中药大辞典（第二版）》", 30 June 2014 * |
| 故晓峰: "《恶性肿瘤中医食疗验方》", 31 January 1999 * |
| 罗卓洲: "《中医中老年养生保健》", 30 April 2014 * |
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