CN104474366A - Pharmaceutical composition for treating porcine malignant edema and preparation method thereof - Google Patents

Pharmaceutical composition for treating porcine malignant edema and preparation method thereof Download PDF

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Publication number
CN104474366A
CN104474366A CN201410694470.2A CN201410694470A CN104474366A CN 104474366 A CN104474366 A CN 104474366A CN 201410694470 A CN201410694470 A CN 201410694470A CN 104474366 A CN104474366 A CN 104474366A
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weight portion
radix
herba
pharmaceutical composition
mastic
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CN201410694470.2A
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郝常宝
黄河
李鑫
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Shandong New Hope Liuhe Group Co Ltd
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Shandong New Hope Liuhe Group Co Ltd
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/804—Rehmannia
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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Abstract

The invention provides a pharmaceutical composition for treating porcine malignant edema and a preparation method thereof. The pharmaceutical composition comprises the following medicinal raw materials: dried radix rehmanniae, radix scrophulariae, moutan barks, lithospermum, folium sennae, aloe, bunge cherry seeds, ramulus mori, Chinese starjasmine stems, erodium stephanianum willd, poria cocos, semen coicis, stigma of corn, calabash, shepherd purse, tetrapanax papyriferus, pyrrosia lingua, rush, herba aristolochiae, pericarpium arecae, rhizoma nardostachyos, paederia scandens, fructus oryzae germinates, uniflower swisscentaury roots, Indian rorippa herb, scabrid smallhooked hedyotis herb, white chinaure herb, scrophulariaceae limnophila rugosa, storax and concha meretricis sea cyclinae. The traditional Chinese medicine composition has the functions of primarily removing heat to cool blood and inducing diuresis to alleviate edema and secondarily preventing bacteria and disinfecting, and can be used for improving the porcine disease resistance and enhancing the immunity while treating porcine malignant edema. The pharmaceutical composition for treating porcine malignant edema has the advantages of being strong in medicament pertinence, direct to focus by efficacy, cheap, free of medicinal residues and toxin, safe and convenient, comprehensive in function and the like.

Description

A kind ofly be used for the treatment of pharmaceutical composition of pig malignant edema and preparation method thereof
Technical field
The present invention relates to field of veterinary, be particularly a kind ofly used for the treatment of pharmaceutical composition of pig malignant edema and preparation method thereof.
Background technology
Malignant edema (Malignat edema) is the acute infectious disease of the microbial multiple domestic animal of multiple shuttle being master by clostridium septicum.Sick feature is that sharply gas inflammatory edema locally occurs wound, and with heating and whole body toxemia.There is generation primary disease countries in the world, and Chinese Pigs also has Sporadic cases.
Pathogenic bacteria: the cause of disease of primary disease is clostridium septicum in fusobacterium (Clostridium), clostridieum welchii, Nuo Weishi clostridium and clostridium histolyticum etc., but in malignant edema case, have 60% separable to clostridium septicum, next is clostridieum welchii, and Nuo Weishi clostridium and clostridium histolyticum only account for 5%.1. clostridium septicum is strict anaerobes, is the Gram-positive escherichia coli of the blunt circle in two ends, can not forms pod membrane, can form brood cell, and brood cell is positioned at thalline central authorities or near-end, and brood cell is oval or circle, is greater than thalline shape as shuttle shape; There are all flagellums, can move.In the medium thalline singly or in short chain shape, if the thalline on the peritoneum or liver surface of dead animal, often form long filament without joint microbend or articulate long-chain shape, this feature has diagnostic value.It is 37 ~ 40 DEG C that this bacterium cultivates optimum temperature, well-grown in the culture medium being added with blood, serum or saccharide.In β haemolysis on blood agar; In anaerobism liver bouillon, well-grown, evenly muddy, last top is limpid, forms canescence flocculent deposit, sinks.This bacterium energy glucose fermentation, maltose, single toffee, fructose, salicin, lactose, produce sour aerogenesis; Azymic sucrose, dulcitol and mannitol; Reduction nitrate, solidifies slowly to litmus milk, does not produce indole and hydrogen sulfide, MR and VP negative.This bacterium can produce multiple extracellular toxin, mainly α, β, γ, δ 4 kinds of extracellular toxins, and alpha toxin is lecithinase, has necrosis, lethal and haemolysis, is the primary toxins of this bacterium; β toxin is deoxyribonuclease, has and kills leukocyte effect; γ and δ toxin has the hemolysin activity of hyaluronidase and not oxytolerant respectively, and they can make vascular permeability strengthen, and make inflammatory seep, and constantly organize diffusion towards periphery, makes muscular tissue downright bad, and infection is spread along the fascia face of muscle.This bacterium extensively exists at nature, has a large amount of antibacterial, can pollute feeding environment and soil in the intestinal of animal and feces.This bacterium spore resistance is to external world very strong, and general sterilization medicinal liquid needs just can kill for a long time; In sterilization medicinal liquid, 10% ~ 20% Eusol, 3% ~ 5% sulphuric acid, carbolic acid mixture, 3% ~ 5% sodium hydroxide, can kill this bacterium thalline at short notice.2. clostridieum welchii (also known as bacillus perfringens) is the Gram-positive escherichia coli of the blunt circle in two ends, singly or become way double-line, seldom there is short chain; Atrichia, can not move; Oval brood cell, is positioned at thalline central authorities or near-end, thalline is expanded; Most bacterial strain can form pod membrane.This bacterium requires not tight to anaerobic condition, ordinary culture medium can grow, if add blood, glucose, grows better; In sheep blood agar culture medium, can grow circle, neat in edge, Lycoperdon polymorphum Vitt to Lycoperdon polymorphum Vitt yellow, smooth surface, translucent bacterium colony, periphery of bacterial colonies has zone of hemolysis.In anaerobism liver bouillon, grow vigorous, cultivate 5 ~ 6h for 37 DEG C, namely see that culture medium is muddy, produce a large amount of gas.This bacterium energy glucose fermentation, maltose, lactose, sucrose, fructose and galactose, produce sour aerogenesis; Azymic salicin, dulcitol, mannitol and rhamnose; Liquefy gelatin, indole produces negative, and " the violent fermentation " of milk culturemedium, produces a large amount of gas and make clot disruption become porous spongy, is washed into several sections or be ejected outside pipe time serious, is the outstanding biochemical characteristic of this bacterium.
Epidemiology: the pathogen of primary disease extensively exists and gives nature, more in livestock intestinal tract sweetening of the soil, becomes the source of infection.Ill domestic animal can not immediate contagion healthy animal, but can pollute external environment.During the edematous site generation ulceration of ill domestic animal, discharge a large amount of pathogen with edematous fluid or slough, contaminated environment.The primary disease route of infection mainly due to wound, castration, bite, dock, surgical operation, the sterilization such as practise midwifery be tight, pollute bacterial spore and infect, causing morbidity, especially with deep wounds, and there is slough, causing anoxia, more susceptible disease.
Clinical symptoms: face and examine visible two kinds of sick types.A kind of is traumatic infection, and show as local diffuse inflammatory edema, the initial stage is solid, has hotness, pain, after become not hot, palpation local is more soft, and firmly visible edema depression, during for twisting, has obvious crepitation; Risings of sick pig performance body temperature, lassitude, appetite are given up the General Symptoms such as exhausted, severe one death in 1 ~ 2 day.Another kind is gastric pattern, and epidemic disease of also expressing one's gratification type, is mainly infected by gastric mucosa, makes gastric mucosa swelling, thickens, and is formed so-called " rubber stomach ".Sometimes pathogenic bacteria also can enter blood flow, is transferred to certain muscle, and limping of arching appears gas inflammatory edema and in local, and General Symptoms is obvious; This case is often in acute process, how dead at 1 ~ 2 day.
Pathological change: cut open the visible site of pathological change diffusivity edema of inspection, cut affected part as seen between subcutaneous and muscle connective tissue have dirty yellow or bronzing liquid-soaked, its sour in the mouth is smelly, and containing bubble; Muscle is in white, and seemingly boiled the same, soft being easy to is torn, and what have is crineous.Organa parenchymatosum's degeneration, the heart, liver, kidney cloudy swelling; Lymphadenectasis, particularly infects the acute enlargement of lymph node of local, and tangent plane is congested, hemorrhage.Blood clotting is bad, and there is volume hydrops in pericardium and abdominal cavity.As being stomach infections, then see thickened stomach wall, matter as rubber-like, therefore has the title of " rubber stomach ".Gastric mucosa flushing, swelling, be filled with pale red and mixed alveolate liquid under mucosa and between muscle layer.Hepatic tissue is mostly also containing bubble.
Differential Diagnosis: face the feature of examining according to primary disease, pathological anatomical change and be combined with wound when occurring, can suspect for primary disease, but needs to carry out lab testing and just can make a definite diagnosis.Antibacterial smear, dyeing, microscopy get pathological changes edematous fluid and tissue, and particularly liver tunicle does contact or smear, with Gram staining method dyeing, and microscopy.In the staining section of liver, can see the Gram-positive escherichia coli of microbend long filament shape arrangement, this is significant in diagnosis.Bacteria distribution is cultivated and is got local edema liquid or hepatic tissue pathological material of disease, is inoculated in anaerobism liver bouillon culture medium, and cultivate 24h for 37 DEG C, liver bouillon is evenly muddy, and produces gas, has precipitation; On glucose blood agar, in faint β haemolysis; Divide pure antibacterial can do biochemical test further.Animal inoculation test is got pathological material of disease and is made 1:10 emulsion suspension liquid, the laboratory animals such as inoculation rabbit, Cavia porcellus, mice or Columba livia, intramuscular injection.Dead in general 18 ~ 24h after inoculation.Injection site, presents obvious hemorrhagic edema, and muscle cerise infiltrates; Get local edema liquid smear, dyeing, microscopy, the escherichia coli of the blunt circle in two ends can be seen, on the staining section of liver surface contact, the escherichia coli of visible long filament shape.Immuno-fluorescent antibody technique can be used for the quick diagnosis of primary disease.Differential Diagnosis is noted diagnosing with the difference of bowel oedema disease and swine pasteurellosis.
Doctor trained in Western medicine control pig malignant edema is sick: to morbidity pig, will isolate in time, treat as early as possible, topical therapeutic and whole body therapeutic can be taked to combine, propagate in case expand.To sick bowel oedema disease position, can cut, expand wound, remove foreign body and slough, repeatedly rinse with 1% ~ 2% potassium permanganate solution or 3% hydrogen peroxide liquid, sterilization, after cleaning up, spreads penicillin, sulfa powder, sulfanilamide iodoform mixture etc. in wound; Later every day can carry out by methods of surgical routinely.And can around edema portion, the antibacterials such as injection penicillin.According to the concrete condition of ill pig, carry out comprehensive whole body and symptomatic therapy, as with antibiotic or and sulfa drugs fit applications, carry out the treatments such as heart tonifying, fluid infusion, removing toxic substances simultaneously.During treatment, edematous fluid, slough and garbage that sick pig wound is discharged should sterilize and burn.Used treatment tool answers thorough disinfection; The pig house that sick pig pollutes and place, the disinfectant liquid disinfectants such as available 2% sodium hydroxide solution or 1% Eusol; Feces, remaining feedstuff and dead corpse are buried after should burning or add sterilization medicinal liquid.
But western medical treatment pig malignant edema is sick, mainly applies antiviral, antibiotic etc. and other chemosynthesis class antibacterials, life-time service, is easy to pathogenic strains is developed immunity to drugs, and the property of medicine declines, and easily causing pig drug residue to increase, harm animal and human body is healthy.Further, more difficult control large area infects the swinery of this disease, causes huge economic loss to culturist.Therefore, the development and application of the medicine of new type of safe just seems increasingly important.
But Chinese medicine is sick in treatment pig malignant edema, not only can improve the resistance against diseases of pig, strengthen its immunity, in treatment pig malignant edema is sick, pointed strong, drug effect is gone directly focus, and inexpensive, nonhazardous, no drug residue, safe ready, complete function, be applicable to large-area applications.
Summary of the invention
Technical problem to be solved by this invention be to provide a kind of be used for the treatment of pig malignant edema there is clearing away heat and cooling blood, inducing diuresis to remove edema is main, and antibiotic and sterilizing is pharmaceutical composition of auxiliary function and preparation method thereof.The present invention has in treatment pig malignant edema simultaneously sick, can improve the resistance against diseases of pig, strengthen its immunity, in treatment pig malignant edema is sick, pointed strong, drug effect is gone directly focus, inexpensive, nonhazardous, drug residue free, can also ensure the growing nutrient demand of pig.
In order to solve the problems of the technologies described above, the invention provides a kind of pharmaceutical composition being used for the treatment of pig malignant edema, wherein, described pharmaceutical composition comprises following raw medicinal material: the Radix Rehmanniae, Radix Scrophulariae, Cortex Moutan, Radix Arnebiae (Radix Lithospermi), Folium Sennae, Aloe, Semen Pruni, Ramulus Mori, Caulis Trachelospermi, geranium, Poria, Semen Coicis, Stigma Maydis, calabash, Herba Capsellae, Medulla Tetrapanacis, Folium Pyrrosiae, Medulla Junci, Herba Aristolochiae, Pericarpium Arecae, Radix Et Rhizoma Nardostachyos, fevervine, Fructus Oryzae Germinatus, Radix Rhapontici, Herba Rorippae, Herba Hedyotis scabridae, Herba Boenninghauseniae Albiflorae, Rhizoma begoniae pedatifidae, Styrax, Concha Meretricis Seu Cyclinae.
In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix Rehmanniae 10-25 weight portion, Radix Scrophulariae 10-20 weight portion, Cortex Moutan 13-25 weight portion, Radix Arnebiae (Radix Lithospermi) 10-24 weight portion, Folium Sennae 7-12 weight portion, Aloe 10-20 weight portion, Semen Pruni 14-24 weight portion, Ramulus Mori 10-25 weight portion, Caulis Trachelospermi 12-26 weight portion, geranium 12-25 weight portion, Poria 10-23 weight portion, Semen Coicis 13-28 weight portion, Stigma Maydis 15-30 weight portion, calabash 15-25 weight portion, Herba Capsellae 14-28 weight portion, Medulla Tetrapanacis 15-25 weight portion, Folium Pyrrosiae 10-20 weight portion, Medulla Junci 10-20 weight portion, Herba Aristolochiae 12-24 weight portion, Pericarpium Arecae 10-20 weight portion, Radix Et Rhizoma Nardostachyos 10-20 weight portion, fevervine 12-22 weight portion, Fructus Oryzae Germinatus 10-24 weight portion, Radix Rhapontici 10-23 weight portion, Herba Rorippae 10-25 weight portion, Herba Hedyotis scabridae 13-27 weight portion, Herba Boenninghauseniae Albiflorae 14-26 weight portion, Rhizoma begoniae pedatifidae 10-26 weight portion, Styrax 12-26 weight portion and Concha Meretricis Seu Cyclinae 10-20 weight portion.
In described pharmaceutical composition, the parts by weight of each raw medicinal material are: the Radix Rehmanniae 15 weight portion, Radix Scrophulariae 20 weight portion, Cortex Moutan 25 weight portion, Radix Arnebiae (Radix Lithospermi) 18 weight portion, Folium Sennae 7 weight portion, Aloe 19 weight portion, Semen Pruni 18 weight portion, Ramulus Mori 19 weight portion, Caulis Trachelospermi 22 weight portion, geranium 25 weight portion, Poria 23 weight portion, Semen Coicis 28 weight portion, Stigma Maydis 30 weight portion, calabash 25 weight portion, Herba Capsellae 28 weight portion, Medulla Tetrapanacis 25 weight portion, Folium Pyrrosiae 20 weight portion, Medulla Junci 14 weight portion, Herba Aristolochiae 22 weight portion, Pericarpium Arecae 16 weight portion, Radix Et Rhizoma Nardostachyos 12 weight portion, fevervine 20 weight portion, Fructus Oryzae Germinatus 18 weight portion, Radix Rhapontici 18 weight portion, Herba Rorippae 25 weight portion, Herba Hedyotis scabridae 18 weight portion, Herba Boenninghauseniae Albiflorae 19 weight portion, Rhizoma begoniae pedatifidae 16 weight portion, Styrax 22 weight portion and Concha Meretricis Seu Cyclinae 14 weight portion.
Preferably, described pharmaceutical composition also comprises the Radix Aucklandiae, Folium Eucalypti Robustae, Herba Polygoni Perfoliati, Folium et cacumen Breyniae Fruticosae and Herba Houttuyniae.
In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix Rehmanniae 10-25 weight portion, Radix Scrophulariae 10-20 weight portion, Cortex Moutan 13-25 weight portion, Radix Arnebiae (Radix Lithospermi) 10-24 weight portion, Folium Sennae 7-12 weight portion, Aloe 10-20 weight portion, Semen Pruni 14-24 weight portion, Ramulus Mori 10-25 weight portion, Caulis Trachelospermi 12-26 weight portion, geranium 12-25 weight portion, Poria 10-23 weight portion, Semen Coicis 13-28 weight portion, Stigma Maydis 15-30 weight portion, calabash 15-25 weight portion, Herba Capsellae 14-28 weight portion, Medulla Tetrapanacis 15-25 weight portion, Folium Pyrrosiae 10-20 weight portion, Medulla Junci 10-20 weight portion, Herba Aristolochiae 12-24 weight portion, Pericarpium Arecae 10-20 weight portion, Radix Et Rhizoma Nardostachyos 10-20 weight portion, fevervine 12-22 weight portion, Fructus Oryzae Germinatus 10-24 weight portion, Radix Rhapontici 10-23 weight portion, Herba Rorippae 10-25 weight portion, Herba Hedyotis scabridae 13-27 weight portion, Herba Boenninghauseniae Albiflorae 14-26 weight portion, Rhizoma begoniae pedatifidae 10-26 weight portion, Styrax 12-26 weight portion, Concha Meretricis Seu Cyclinae 10-20 weight portion, Radix Aucklandiae 10-20 weight portion, Folium Eucalypti Robustae 12-24 weight portion, Herba Polygoni Perfoliati 12-20 weight portion, Folium et cacumen Breyniae Fruticosae 10-20 weight portion and Herba Houttuyniae 10-18 weight portion.
In described pharmaceutical composition, the parts by weight of each raw medicinal material are: the Radix Rehmanniae 15 weight portion, Radix Scrophulariae 20 weight portion, Cortex Moutan 25 weight portion, Radix Arnebiae (Radix Lithospermi) 18 weight portion, Folium Sennae 7 weight portion, Aloe 19 weight portion, Semen Pruni 18 weight portion, Ramulus Mori 19 weight portion, Caulis Trachelospermi 22 weight portion, geranium 25 weight portion, Poria 23 weight portion, Semen Coicis 28 weight portion, Stigma Maydis 30 weight portion, calabash 25 weight portion, Herba Capsellae 28 weight portion, Medulla Tetrapanacis 25 weight portion, Folium Pyrrosiae 20 weight portion, Medulla Junci 14 weight portion, Herba Aristolochiae 22 weight portion, Pericarpium Arecae 16 weight portion, Radix Et Rhizoma Nardostachyos 12 weight portion, fevervine 20 weight portion, Fructus Oryzae Germinatus 18 weight portion, Radix Rhapontici 18 weight portion, Herba Rorippae 25 weight portion, Herba Hedyotis scabridae 18 weight portion, Herba Boenninghauseniae Albiflorae 19 weight portion, Rhizoma begoniae pedatifidae 16 weight portion, Styrax 22 weight portion, Concha Meretricis Seu Cyclinae 14 weight portion, the Radix Aucklandiae 14 weight portion, Folium Eucalypti Robustae 16 weight portion, Herba Polygoni Perfoliati 20 weight portion, Folium et cacumen Breyniae Fruticosae 15 weight portion and Herba Houttuyniae 16 weight portion.
For solving the problems of the technologies described above, present invention also offers a kind of preparation method being used for the treatment of the pharmaceutical composition of pig malignant edema, wherein, when the dosage form of described pharmaceutical composition is granule, its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 3 ~ 5 times, mixture is the ethanol of 84% ~ 90%, be heated to boiling reflux 2 ~ 4 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 55 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.02 ~ 1.08, spraying dry, the inlet temperature 165 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.1 ~ 0.3 times and 0.1 ~ 0.3 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.
Wherein, when the dosage form of described pharmaceutical composition is tablet, its preparation method comprises the following steps:
The first step, by Ramulus Mori, Caulis Trachelospermi, geranium and Poria mixing, add relative to mixture 3 ~ 5 times amount determining alcohol be 75% ~ 85% alcohol reflux 2 ~ 4 times, each 2 ~ 3 hours, filter, filtrate merges, reclaim ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.20 ~ 1.22, for subsequent use;
Second step, is mixed in proportion described for residue raw medicinal material, adds relative to mixture 2 ~ 4 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.21 ~ 1.24;
3rd step, the mastic mixing that the first step, second step are obtained, 75 DEG C ~ 85 DEG C reduced vacuum dryings, get dry extract powder;
4th step, carries out mixing by described dried cream powder and starch and processes, obtain mastic mixture; Described mastic and the weight ratio of starch are 1: 0.01 ~ 0.02; Described mastic mixture is carried out pelletization treatment, dried, the mastic compound particles obtained;
5th step, described mastic compound particles and the Pulvis Talci of 1 ~ 3 times amount, the magnesium stearate of 0.15 ~ 0.3 times amount are carried out successively mixing processes, tabletting process, Cotton seeds, obtain Chinese medicine preparation tablet finished product.
The invention has the beneficial effects as follows: the present invention treats pig malignant edema disease and has clearing away heat and cooling blood, inducing diuresis to remove edema is main, antibiotic and sterilizing is auxiliary effect, can improve the resistance against diseases of pig, strengthen its immunity, in treatment pig malignant edema is sick, pointed strong, drug effect is gone directly focus, good effect, curative effect is fast, and inexpensive, nonhazardous, drug residue free, can also ensure the growing nutrient demand of pig.
Detailed description of the invention
Chinese veterinarian thinks, the operation of body water liquid, depends on the promotion of gas, and the liter namely depending on temper is transferred, and the Xuan Jiangtong of lung qi adjusts, the promotion of the motive, kidney qi evaporate folding.These functions are normal, then three burnt performances certainly show disrespect on effect, and functioning of bladder passes unimpeded, normal urination, can maintain the metabolism of normal water liquid.Otherwise if because of the damp and hot heresy of affection of exogenous wind-cold, the wet dipping of water, sore is contaminated, and diet, weakness due to chronic disease etc. cause above-mentioned visceral dysfunction, and three Jiao certainly show disrespect on mistake department, and functioning of bladder is unfavorable, and water retention in body, spreads unchecked skin, can send out as edema.
The above-mentioned various cause of disease, has and singlely causes patient, also having and holds concurrently assorted and cause patient, thus making the state of an illness be tending towards complicated.The sick position of primary disease is dirty at lung, spleen, kidney three, has substantial connection with the heart.Basic pathogenesis is the logical tune of impairment of dispersing and descending function of the lung, and spleen loses and transfers, and kidney loses folding, and functioning of bladder is not normal, causes water retention in body, spreads unchecked skin.In pathogeny, lung, spleen, kidney three is dirty connects each other, influences each other, and the suffering from edema as lung spleen swells, for a long time must and kidney, cause suffering from a deficiency of the kidney and edema being increased the weight of; Kidney yang deficiency, the not warm soil of fire, then spleen sun is also empty, the spleen failing to restrict the kidney, then make edema more very; Edema due to deficiency of the kidney, superinverse violates lung, then lung-QI being unable to descend, loses the function that logical tune falls in its a surname, and increases the weight of edema.Because of exopathogen, sore, damp and hot caused edema, sick position is many at lung spleen; Because of the edema caused by internal injury, sick position is many at spleen kidney.Therefore, the dirty morbidity with edema of lung spleen kidney three, is take kidney as this, take lung as mark, and be the dirty of controlling the water circulation with spleen, just as " Jing Yue's complete work swelling " institute cloud: " card such as all edema is the dirty relevant disease of lung spleen kidney three.Lid water is Zhiyin, therefore the fundamental cause of water disease being in the kidney; Aquation is in gas, therefore it is marked on lung; Water only fears soil, therefore it is built in spleen.The modern deficiency of the lung then vital QI failing to transform into essence and change water, insufficiency of the spleen then the spleen failing to restrict the kidney and anti-gram: suffer from a deficiency of the kidney then water without main and absurd row.”
Therefore, the present invention is with clearing away heat and cooling blood, inducing diuresis to remove edema is main, be that auxiliary Therapeutic Principle treats pig malignant edema with antibiotic and sterilizing sick, select prescription: the Radix Rehmanniae, Radix Scrophulariae, Cortex Moutan, Radix Arnebiae (Radix Lithospermi), Folium Sennae, Aloe, Semen Pruni, Ramulus Mori, Caulis Trachelospermi, geranium, Poria, Semen Coicis, Stigma Maydis, calabash, Herba Capsellae, Medulla Tetrapanacis, Folium Pyrrosiae, Medulla Junci, Herba Aristolochiae, Pericarpium Arecae, Radix Et Rhizoma Nardostachyos, fevervine, Fructus Oryzae Germinatus, Radix Rhapontici, Herba Rorippae, Herba Hedyotis scabridae, Herba Boenninghauseniae Albiflorae, Rhizoma begoniae pedatifidae, Styrax, Concha Meretricis Seu Cyclinae.Preferably, the Radix Aucklandiae, Folium Eucalypti Robustae, Herba Polygoni Perfoliati, Folium et cacumen Breyniae Fruticosae and Herba Houttuyniae is also comprised.
Wherein, the Radix Rehmanniae, Radix Scrophulariae, Cortex Moutan, Radix Arnebiae (Radix Lithospermi), Radix Rhapontici, Herba Rorippae, Herba Hedyotis scabridae, the hot removing heat from blood of Herba Boenninghauseniae Albiflorae, nourishing yin and purging fire; Folium Sennae, Semen Pruni, Aloe loosening bowel to relieve constipation, inducing diuresis to remove edema; Ramulus Mori, Caulis Trachelospermi, geranium, Poria, Semen Coicis, Stigma Maydis, calabash, Herba Capsellae, Medulla Tetrapanacis, Folium Pyrrosiae, Medulla Junci, Rhizoma begoniae pedatifidae, Styrax, Concha Meretricis Seu Cyclinae inducing diuresis to remove edema, expel the heat-evil, removing heat from blood; Herba Aristolochiae, Pericarpium Arecae, Radix Et Rhizoma Nardostachyos, fevervine, Fructus Oryzae Germinatus spleen invigorating eliminating dampness by diuresis, inducing diuresis to remove edema.The Radix Aucklandiae, Folium Eucalypti Robustae, Herba Polygoni Perfoliati, Folium et cacumen Breyniae Fruticosae and Herba Houttuyniae antibiotic and sterilizing, auxiliary treatment.Make a general survey of full side, compatibility is rigorous, reasonable, evident in efficacy.
Now each taste medicine is described below:
The Radix Rehmanniae: sweet, cold; GUIXIN, liver, kidney channel.Shennong's Herbal: " sweet in the mouth, cold.Cure mainly folding to fall, exhausted muscle, damaging the spleen and stomach, by arthralgia due to stagnation of blood, fill out bone marrow, longue meat.Make soup except cold and heat and gather, eliminating impediment.Survivor is especially good." heat clearing away, promote the production of body fluid, moisturize, laxation, removing blood stasis with potent drugs, tissue regeneration promoting, pain relieving, regulating menstruation, removing heat from blood, hemostasis invigorate blood circulation.The Radix Rehmanniae is cold in nature, and function is heat clearing and blood cooling, enriching yin and nourishing kidney, promoting the production of body fluid to quench thirst, is usually used in the diseases such as treatment hectic fever due to YIN-deficiency consumptive disease heat, throat pain, sputum mixed with blood.By by the Radix Rehmanniae with Fructus Amomi, wine, Pericarpium Citri Reticulatae for adjuvant, repeatedly steam and shine to color blackening, quality softness is namely in order to Radix Rehmanniae Preparata, and the LIUWEI DIHUANG WAN having Radix Rehmanniae Preparata to make, be exactly famous the kidney invigorating good medicine, the clinical treatment being also usually used in the diseases such as chronic nephritis, hypertension, neurasthenia, pulmonary tuberculosis.
Radix Scrophulariae: sweet in the mouth, hardship, salty, cold nature, returns lung, stomach, kidney channel.Compendium of Material Medica: " kidney water is injured, Kidney-Yin fall, lonely positive unrooted, and send out as fire is sick, method should strengthen water with fire processed, therefore Radix Scrophulariae and the same merit of Radix Rehmanniae.Its scrofula that disappears also is loose fire, and it is that fire is sick that Liu keeps the truth tuberculosis." " Records of Tradition Chinese and Western Medicine in Combination ": " many liquid cool in nature was the medicine of the kidney invigorating warp clearly originally for Radix Scrophulariae, sweet and slightly bitter taste.Can enter again lung with the bright heat of lung heat clearing man, removing toxic substances quench, is suitable for pneumonopathy tuberculosis most, cough due to lung-heat." " Japan hanako materia medica ": " control wind syndrome of head pyretic toxicity urticaria, tonify deficiency strains, and the heart is frightened irritated, and bad weary hectic fever due to YIN-deficiency passes corpse pathogen, only forgetful, detumescence poison." there is clearing away heat and cooling blood, eliminating fire and detoxication, effect of YIN nourishing, cure mainly warm febrile disease and nutrient blood, fever of the body, excessive thirst, crimson tongue, the cards such as constipation, order puckery dim-sighted, throat larynx swells and ache, scrofula sucutaneous nodule, skin sore are not hindered in awake, Tianjin to send out speckle, hectic fever due to YIN-deficiency chronic cough, fidgets due to deficiency.
Cortex Moutan: bitter in the mouth, pungent, cold nature, enters the heart, liver, kidney channel." herbal classic ": " main cold and heat, apoplexy Chi Zong, convulsion, infantile convulsion pathogen, except the hard blood stasis of disease stays house the intestines and stomach, settling five organs, treat carbuncle skin ulcer." " Japan hanako materia medica ": " except pathogen, happy color, clearance natural fibre line of meat blood vessels, evacuation of pus, logical menstruation, disappear and flutter damage blood stasis, reuniting the fractured tendons and bones, except migratory arthralgia, fall tire lower eyelid, puerperal all cold and hot vim and vigour."。Compendium of Material Medica: " nourishing YIN to lower pathogenic fire separates speckle poison, throat, diuresis stasis.Descendant specially controls fire mutually with yellow tiller, does not know that the merit of Cortex Moutan more wins also.Red colored person's profit, the person of spending in vain mends, and people also seldom realizes, and should distinguish it." there is the effect of clearing away heat and cooling blood, promoting blood circulation to remove blood stasis, be mainly used in the treatment epidemic febrile disease pathogenic heat attacking blood system in febrile diseases, send out speckle, tell nosebleed, calentura later stage hot Fu Yin divides heating, deficiency of YIN osteopyrexia and fever, amenorrhea due to stagnation of blood, dysmenorrhea, carbuncle sore tumefacting virus, falls and flutter the card such as the pain of injury, beriberoid pyretic arthralgia.Be apt to purify the blood, and invigorate blood circulation, thus have effect of cool the blood dissipate blood stasis, make blood flow freely and not stay the stasis of blood, the absurd clearly and not row of heat in blood.Therefore to diseases such as intense heat in the blood, Liver and kidney hyperactivity of fire and stagnation of blood stasis, all rely on as key medicine.Cortex Moutan can increase coronary flow to the anesthetized dog heart, reduces cardiac output, reduces the effect of left room work done.The mice heating that paeonol oral disposition typhoid fever, paratyphoid vaccine cause has refrigeration function, and reduces normal mouse body temperature.
Radix Arnebiae (Radix Lithospermi): cold in nature, sweet in the mouth, salty, GUIXIN, Liver Channel, Compendium of Material Medica: " Radix Arnebiae (Radix Lithospermi), its merit is longer than removing heat from blood and promoting blood circulation, sharp intestine and small intestine.Therefore varioliform exanthema is for going out out, heat in blood poison is contained, and stool closes puckery person and with it, should go out and the purple melena person of cutting also can use.If go out and red work, and white fall into convenience person, cut compatibility and incompatibility of drugs it." " Bencao Jingshu ": " Radix Arnebiae (Radix Lithospermi) is the key medicine of removing heat from blood, therefore the gas of main trusted subordinate's pathogenic heat." be mainly used in that heat in blood poison is contained, macule purple black, measles without adequate eruption, skin infection, eczema, burn due to hot liquid or fire etc.The ether of Radix Arnebiae (Radix Lithospermi), water, ethanol extraction all have certain antiinflammatory action.Oral refrigeration function rabbit experiment heat pyrexia being had to mitigation of Radix Arnebiae (Radix Lithospermi) decoct, its extract and pigment composition also have slight refrigeration function.
Folium Sennae: sweet, bitter, cold.Return large intestine channel.Cure mainly the row that purges heat stagnant, relieving constipation, diuretic.Stagnate for accumulation of heat, constipation is suffered from abdominal pain, edema distension.These product contain Sennoside A and Sennoside B, and containing Herba Alii fistulosi ketone derivatives: aloe-emodin, chrysophanol, chrysophanic acid etc.Have Folium Sennae and can make medicinal discharge function and antibacterial action, Folium Sennae also has curariform action mask.Under gastroscope, be sprayed on gastrorrhagia place with this product infusion, direct-view has anastalsis at once as seen.
Aloe: bitter in the mouth is cold in nature, removing heat from the liver, relieving constipation, parasite killing; In addition for headache, constipation, pediatric epilepsy scared, infantile malnutrition infections furuncle and phyma, burn and scald, tinea skin ulcer, hemorrhoid, atrophic rhinitis, scrofula, hepatitis, Biliary Calculi, exudative dermatitis etc.Containing more than 200 kinds of compounds in the blade of Aloe, in the middle of include 20 kinds of mineral, 18 seed amino acids, 12 kinds of vitamin and other various different nutrients, comprise multiple mucopolysaccharide, fatty acid, Anthraquinones and flavone compound, sugar, organized enzyme etc.Anthraquinones has another name called Anthraquinone Complex, has effect of disinfection, is mainly present in juice.
Semen Pruni: pungent, bitter, sweet, flat.Return spleen, large intestine, small intestine meridian.Function cures mainly: moisturize laxation, the therapeutic method to keep the adverse QI flowing downwards, diuretic.For intestine-dryness due to consumption of fluid, stagnation of QI due to dyspepsia, abdominal distention constipation, edema, beriberi, dysuria.Contained by Semen Pruni, Semen Pruni glycoside has strong discharge function to laboratory animal.The protein component IR-A raised from Semen Pruni and IR-B intravenously administrable have antiinflammatory and analgesic activity.Semen Pruni has the significant effect promoting small intestinal peristalsis. and strongly fragrant Lee's glucoside has strong discharge function to laboratory animal, also has calmness and diuresis.Strongly fragrant Lee's glucoside and Senna Fructus are both large intestine cathartic, but the former side effect is little compared with the latter.
Ramulus Mori: bitter in the mouth, sweet, cold in nature; Return lung, Liver Channel.Supplement to the Herbal: " main abdominal pain due to acute vomiting and diarrhea is told down, and the eleventh month of the lunar calendar takes it with dense the boiling of dry person.Smooth file, takes as red sugar in large still, removes old wind and stagnated blood." " Japan hanako materia medica ": " sharp the five internal organs, get round by bribery, the therapeutic method to keep the adverse QI flowing downwards, decoction; Except wind pain is perspired, and flutter damage blood stasis, and Zheng Hou An; Scolopendra stings snakeworm, and salt Norway applies." Folium Mori energy dispelling wind and heat pathogens, heat clearing away of inducing sweat, YIN nourishing and the production of body fluid promoting; Fructus Mori energy nourishing YIN and benefiting blood, tonify deficiency is moisturized; The eliminating pathogen from the lung for relieving asthma of Cortex Mori energy, inducing diuresis to remove edema; Ramulus Mori energy dredge the meridian passage, eliminating impediment pain relieving; And the ash that mulberry burns till is Pulvis Lignum Mori, also can be used for the treatment of conjunctival congestion and swelling pain, optic atrohic blindness, body face edema, sitting and lying must not, the disease such as vitiligo, seborrheic dermatitis of the scalp, leprosy.
Caulis Trachelospermi: bitter, is slightly cold.GUIXIN, liver, kidney channel." herbal classic ": " carbuncle does not disappear, and mouthpiece swells for the dead flesh carbuncle wound of main air heat, xerostomia scorching tongue, water slurry not under." Tang Materia Medica: " treat blood agglomeration in puerperal.Agkistrodon halys skin ulcer, strand extracting juice washes it, takes juice and also goes the snake venom heart vexed; The all skin ulcers of injury by sword or axe, Feng Zhi." there is expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, clearing away heat and cooling blood, effect of removing toxic substances and promoting subsidence of swelling, cures mainly dispelling wind and removing obstruction in the collateral, and removing heat from blood is subsided a swelling.For beriberoid pyretic arthralgia, the contracture of muscle arteries and veins, soreness of waist and knee joint, sore throat, carbuncle, injury from falling down.The dull and stereotyped trench method of this product 50% decoct, has inhibitory action to staphylococcus aureus, shigella flexneri and Bacillus typhi.
Geranium: bitter, micro-pungent is flat.Return liver, kidney, large intestine channel." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " control meridian hectic fever, dizzy, be afraid of cold, limbs are aching and tired, poor appetite, the virgin infantile malnutrition of male geranium woman, deficient fever do not move back person with it, diuresis, buffalo meat is for drawing." remove rheumatism, for rheumatic arthralgia.The extract of the wild geranium root of geranium contains flavonoid, catechin, tannin, and wherein the effect of resisiting influenza virus is the most obvious to suppress copy (as influenza, herpes simplex, cowpox, the HIV-I) of multiple virus.Geranium can suppress liver mitochondrion and MC lipid peroxidation, reduces plasma cholesterol and GOT/GPT level, suppresses the mitochondrial lipid peroxidation effect brought out by ADP and ascorbic acid.The sterile water solution of geranium extract all has inhibitory action to shigella flexneri, escherichia coli, staphylococcus aureus, bacillus pyocyaneus in vitro.
Poria: sweet, light is flat.GUIXIN warp, lung meridian, spleen channel, kidney channel.Function: diuretic medicine; Diuretics with the action of eliminating dampness." medication heart method ": " sweet with supporing yang, the panacea of dehumidifying also for Poria, the sharp key of light energy.The flat YANG invigorating of sweet in the mouth, strengthening the spleen is relieved oedema or abdominal distension through diuresis or purgation, inducing QI of promoting the production of body fluid." modern study shows that the effect that Poria has an enhancing immunity can many-sided regulate immunologic function.Poria has significant inhibitory action to staphylococcus aureus, Bacillus proteus.Concoct: be soaked in water, clean, slightly steam after profit, cut skin and block in time or cut sheet, drying.Medication is avoided: the deficiency of YIN and without damp and hot, deficiency and coldness spermatorrhea, the careful clothes of collapse of QI person.Collective Notes to the Canon of Materia medica: " Chinese small iris makes for it.Dislike and hold back in vain.Fear Rhizoma Paridis tetraphyllae, Radix Sanguisorbae, Realgar, Radix Gentianae Macrophyllae, Carapax Et Plastrum Testudinis.”
Semen Coicis: cool in nature, sweet in the mouth, light, return spleen, stomach, lung meridian.The several amino acids of rich in starch and needed by human body, there is the effect such as invigorating spleen to remove dampness, clearing away heat and discharging pus, be applicable to have loose bowels, muscle arteries and veins contracture joint stuffiness, the disease such as edema, beriberi, acute appendicitis, leucorrhea, Semen Coicis can be used as medicine, and is used for treating edema, beriberi, diarrhea due to hypofunction of the spleen etc.Make skin smooth, reduce wrinkle, eliminate effect of pigment spot.Have obvious curative effect to face acne and pachylosis, in addition, it also has absorbability to ultraviolet, and its extractive matter adds in cosmetics also can reach sun-proof and effect that is anti-ultraviolet.Be suitable for various cancer patient, arthritis, acute and chronic nephritis edema, cancer ascites, puffiness of the face and limbs, vitamin B1 deficiency edema person, warty vegetation, beauty treatment person, juvenile verruca plana, common wart, molluscum contagiosum, young acne pimple and the coarse person of other skin malnutrition, be suitable for consumptive lung disease, lung abscess person eats.
Stigma Maydis: sweet in the mouth is put down, Compendium of Material Medica: " Limonitum, hands, the positive bright blood system heavy prescription of foot are also.Its property is puckery, therefore all diseases before and after the main part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels.The first poem of Li Zhi is said, and the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels has the difficult meeting of patient, must use surplus grain Halloysitum Rubrum." " book on Chinese herbal medicine is looked for the truth ": " Limonitum merit is identical with Halloysitum Rubrum, and the matter of Limonitum, overweight Halloysitum Rubrum, the temperature of Halloysitum Rubrum, too surplus grain, must distinguish." there is the effect such as inducing diuresis to remove edema, blood pressure lowering, hemostasis, function of gallbladder promoting, can various diseases be treated.Stigma Maydis can accelerate Blood Coagulation Process, improves number of platelets, can anti-hemolysis, so can to hold concurrently diuretic as hemorrhage, is applied to bladder and lithangiuria, can also be used for acute hemolytic anemia.Because it has anti-allergic effects, so also may be used for treating urticaria and asthma etc.The function of detoxification of Stigma Maydis can be used for treating mastitis etc.In addition, Stigma Maydis also has appetizing effect.
Calabash: calabash sweet in the mouth, property is smoothly nontoxic, and it is climing, palpus, leaf, flower, son, shell all can be used as medicine, and cures various diseases.Record according to ancient medical book, flower of Herba Eichhorniae sweet in the mouth, property is put down, nontoxic, can do the medicine detoxified, particularly effective to various fistula skin ulcer.Climing, must the property of medicine with spend identical, numb skin ulcer can be controlled.Calabash flesh and son, bitter in the mouth, cold in nature, poisonous, can odontopathy be controlled, gingiva or swollen or dew, odontoseisis.Appearance, edema in the extremities can be controlled again, urinary obstruction, nasal obstruction, and all carbuncle malignant boil.Especially the highest with the medical value of calabash shell, its sweet in the mouth, property is put down, and nontoxic, for heat reliving and toxin-eliminating, lung moistening is convenient.
Herba Capsellae: be slightly cold is sweet, light.Energy cooling blood for hemostasis, promoting urination to remove dampness, liver heat removing and eyesight improving." modern Practical Chinese medicinal ": " hemostasis, controls pneumorrhagia, metrorrhagia, miscarry hemorrhage, menorrhagia, headache, ophthalmalgia or retinal hemorrhage." Herba Capsellae has the effect of similar Ergota.Its extractum is tried out and to be left one's post uterus or intestinal tube in animal, all in significantly shrinking.(containing the oxalic acid) intravenous injection of Herba Capsellae extract or intramuscular injection (each 2-3ml, every 2-4 hour 1 time, every day the most multiplex 15ml) in various hemorrhage, have obvious anastalsis.The alcohol extract of Herba Capsellae, to dog, cat, rabbit, rat intravenous injection, can produce transient blood pressure drops, and this effect is not by 80 μ g/kg atropine institute antagonisms.
Medulla Tetrapanacis: sweet in the mouth, light, cold nature; Enter lung, stomach warp." Japan hanako materia medica ": " improving eyesight, brings down a fever, and expedites the emergence of, lower eyelid, stimulating milk secretion." " Changsha medicine solution ": " stimulate the menstrual flow and close, treat jaundice, eliminating carbuncle cellulitis, sharp nose carbuncle, except vexed." clear snobbish water, lactogenesis.The puckery pain of main stranguria, dysuria, edema, jaundice, damp-warm diseases, oliguria with reddish urine, puerperal, breast was few, amenorrhea, leukorrhagia.For hygropyrexia dark coloured urine, the puckery pain of gonorrhea, edema oliguria, agalactia.This product gas is trembled with fear lightly seasoned and body light, and enter lunar lung meridian, drawing heat declines and diuresis, both treating stranguria, subsides a swelling again.Especially be suitable for the dysuria of pyretic stranguria, drench the puckery pain of drop, Medulla Tetrapanacis has diuresis, and obviously can increase urine potassium output, has effects such as promoting galactopoiesis.Medulla Tetrapanacis polysaccharide has certain immunity moderation and antioxidative effect.
Folium Pyrrosiae: cold nature, sweet in the mouth, hardship.Feeble QI, the micro-puckery hardship of taste.Shennong's Herbal: " Folium Pyrrosiae, bitter in the mouth is put down, main consumptive fever pathogen, and five difficulty in urinations are obstructed, and diuresis water leads to, a stone fasten hide or leather on (sound sugarcane), on the stone of raw mountain valley." " Bencao Congxin ": " and calculogenesis the moon place, pliable and tough as skin.Person in raw GUWA, name Herba Lepisori Thunbergiani, controls pouring also good." " book on Chinese herbal medicine is high former ": " Folium Pyrrosiae cures mainly consumptive fever pathogen person, and consumptive fever is at bone, and pathogen is at skin, and the institute of lung kidney is main also.Five infirmity persons, the five liquid difficulty in urinations, dysuria also.Folium Pyrrosiae helps the vital essence of lung kidney, and upper downcrossings, crystal is moistened, then the outer key of upper orifices is all logical, changes under lung qi, then capable the and normal urination of water channel." function relieving stranguria by diuresis, lung heat clearing expels the heat-evil.Control and drench pain, hematuria, lithangiuria, nephritis, metrorrhagia, dysentery, cough due to lung-heat, chronic tracheitis, incised wound, carbuncle.The cytophagous activate the phagocytic capacity of Folium Pyrrosiae energy enhancing body, and have some antitumaous effect.100% Folium Pyrrosiae decoct flat board burrow method, have inhibitory action to staphylococcus aureus and Bacillus proteus.
Medulla Junci: to be slightly cold, sweet, light; GUIXIN, lung, small intestinal, urinary bladder channel." Bencao Jingshu ": " Medulla Junci, its light weight leads to, and it is cold in nature, slightly sweet flavor, therefore can tonneau small intestinal steam, descendingly goes out from urine, and small intestinal is the internal organs of the heart, therefore also except heart channel heat also." function relieving stranguria by diuresis, clearing heart fire.Cure mainly: gonorrhea, edema, dysuria, the puckery pain of oliguria, jaundice due to damp-heat, dysphoria and insomnia, the nocturnal fretfulness in infants, sore throat, aphtha of the mouth and tongue, wound.Experiment proves that this product has diuresis, anastalsis.Treating acute and chronic pharyngitis, stomatitis.
Herba Aristolochiae: bitter, temperature; Enter liver,spleen,kidney warp." Bencao Tujing ": " Xie Fenglao.Herba Ephedrae then cures the wound cold diaphoresis, with Radix Et Rhizoma Rhei with taking gas." " book on Chinese herbal medicine is new again ": " removing heat from blood and promoting blood circulation, removes wind dampness removing, walks meridians, doublely controls the swollen pain of waist lower limb." circulation of qi promoting removing dampness, promoting blood circulation and stopping pain.Treat for stomachache, colicky, edema during pregnancy, puerperal, vim and vigour were suffered from abdominal pain, rheumatalgia.Promoting flow of QI and blood, pain relieving, diuresis.Edema during pregnancy, breast is suffered from abdominal pain, colic, rheumatalgia.Herba Aristolochiae, gas is invigorated blood circulation, and controls the medicine of all pains also.The gas of the person, suitable then peaceful, the inverse then vexed work of pain.As Young " side of directing at " Herba Aristolochiae controls the brachialgia of expectorant note, gas stays colic, and abdominal mass is gathered, and renal mass is suffered from abdominal pain, and puerperal, vim and vigour were suffered from abdominal pain, and he is as edema during pregnancy, edema over the face tachypnea, man's wind labor, and chronic cough is not healed, and knows and controls it with this medicine, peace of invariably getting into bed.Gai Weiqi is good at popular vim and vigour therefore also.See book discuss and cure mainly, only belong to the diseases such as pregnant edema during pregnancy, stomachache, wind consumptive disease, in his disease then not and here.Its reason controlled i.e., also only because bitter in the mouth master is in catharsis, warm in nature being led to lives, therefore passage of invigorating blood circulation, and makes water without unfavorable, and wind removes invariably, blood work invariably, and pain to be controlled therefore also all invariably with swollen.
Pericarpium Arecae: acrid in the mouth, slightly warm in nature; Return spleen, stomach, large intestine, small intestine meridian." Kaibao Bencao ": " main cold and hot gas is made a psychological attack abdomen, and large intestine stops up poison, expectorant diaphragm, the belching of acid from stomach.And decoct with Jiang Yantong, enter thin gas medicine good." " detailed outline ": " beriberi is stopped up inverse, subtertian malaria feeling of fullness, nausea malignant histocytosis feeling of distension and oppression for lowering the adverse flow of QI, aqueous vapor edema in the skin that disappears." " property of medicine class is bright ": " and Pericarpium Arecae, Dan Xi conventional to control lung qi dyspnea with rapid and short breath, and in edema medicine again multiplex it, lid is also got it and is let out lung, to kill the source of water also." therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, line water detumescence.For retention of damp leading to blockage of QI, breast abdominal distention is vexed, defecates not well, edema, beriberi, dysuria.Rabbits infestines tonicity can be made to raise to the effect Pericarpium Arecae decoct of intestinal smooth muscle, shrinkage amplitude reduces, and its effect can by atropine institute antagonism.
Radix Et Rhizoma Nardostachyos: acrid in the mouth, sweet, warm in nature; Return spleen, stomach warp.Compendium of Material Medica: " Radix Et Rhizoma Nardostachyos, it is strongly fragrant that fragrance can open spleen, adds in taste medicine less, gas of being very amusing "." Japan hanako materia medica ": " control abdominal distnetion, the therapeutic method to keep the adverse QI flowing downwards." to have fragrance row loose for Radix Et Rhizoma Nardostachyos, warming spleen and stomach for dispelling cold, regulating QI to relieve pain, the effect of appetizing of being amusing.Cure mainly coldness and pain in the epigastrium distension, anorexia, chest pain, toothache, tumbling down is grieved, beriberi edema, cramp caused by acute vomiting and diarrhea.Jatamansi volatile oil has faint antibacterial, wind dispelling and spasmolysis, to skin, mucosa without local irritation.Jatamansi is to rabbit hemostasis, and rabbit performance is to the bradykinesia, sleepy, the loss of appetite that stimulate.Radix Et Rhizoma Nardostachyos alcohol extract has blood pressure lowering and antiulcer action.
Fevervine: property is put down, sweet in the mouth, micro-hardship." the SHENGCAO property of medicine is standby to be wanted ": " its head controls new internal injury, and pot is carnivorous, and tonify deficiency kidney tonifying, except fire is enriched blood; Wash skin ulcer pain relieving, the loose poison of the heat that disappears.Its leaf beats rice with confectionery, dysentery relieving." " Zhiwu Mingshi Tukao ": " be wash, removing toxic substances, removes wind, heat clearing away, cold expelling.Apply innominate toxic swelling, and mend muscles and bones." expelling wind and activating blood circulation, analgesic antidotal, dyspepsia and intestinal stasis relieving, dehumidifying detumescence.Dispelling the wind and dampness pathogens pain, diarrhoea dysentery, dirty abdomen pain, deficiency of vital energy edema, dizzy lack of appetite, hepatosplenomegaly, scrofula, acute appendicitis, innominate toxic swelling, traumatic injury.Fevervine total alkaloids lumbar injection can suppress mice voluntary activity, extends pentobarbital sodium length of one's sleep, has certain sedation.Fevervine total alkaloids can suppress myenteron to shrink, and the myenteron contracture caused by energy antagonism acetylcholine.Fevervine decoct has inhibitory action to S. aureus in vitro and Fu Shigella flexneri, and extractum also has bacteriostasis to staphylococcus aureus and streptococcus pneumoniae.
Fructus Oryzae Germinatus: nature and flavor are sweet is flat.Return spleen, stomach warp, Liver Channel." Japan hanako materia medica ": " appetizing, only cholera, relieving restlessness, expectorant, broken crux, can expedite the emergence of tire for warming middle-JIAO, the therapeutic method to keep the adverse QI flowing downwards." " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " anti-nausea, disappear dyspepsia, only acid regurgitation acid regurgitation, antidiarrheal, the wide diaphragm of the stomach that disappears, and control married woman's milk breast and do not receive, and milk is more than for alleviating distention in middle-JIAO, the therapeutic method to keep the adverse QI flowing downwards." there is promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite, move back effect of newborn relieving distension.Cure mainly food stagnation not disappear, abdominal distention, insufficiency of the spleen lack of appetite, newborn antiperspirant smoulders, distending pain of the breast, and women weans.
Radix Rhapontici: nature and flavor hardship is salty, cold.1. " herbal classic ": " bitter in the mouth is salty, cold." 2. " not Lu ": " Great Cold, nontoxic.' 3. " book on Chinese herbal medicine is just ": " taste is micro-salty, cold in nature, slightly poisonous." return through entering stomach, large intestine channel.1. Li Gao: " hands, foot sun are bright." 2. " wood grass is from new ": " enters stomach, large intestine, logical lung, small intestinal." 3. " beautiful Chinese catalpa medicine solution ": " enters kidney meridian, liver channel of foot-Jueyin." function cures mainly heat-clearing and toxic substances removing, detumescence and apocenosis, stimulating milk secretion, logical muscle arteries and veins.Control carbuncle carbuncle on the back, breast swell and pain.Galactostasis, scrofula malignant boil, arthralgia chiefly caused by damp pathogen muscle arteries and veins is restrained, arthralgia, toxic-heat and blood stasis, bleeding hemorrhoids.1. " herbal classic ": " main skin heat, malignant boil cellulitis hemorrhoid, arthralgia chiefly caused by damp pathogen, lower milk." 2. " not Lu ": " only incontinence of urine, herpes simplex is itched as numb bean, can do to bathe soup." 3. TAO Hong-Jing: " treats all fistula scabies.Pyretic toxicity malignant boil humorously on " 4. " property of medicine opinion t ": " training the body, musculus cutaneus pruritus urticaria." 5. supplement to the Herbal: " parasite killing, washes skin ulcer scabies and uses it." 6. " Japan hanako materia medica ": " controls children's's high fever, and logical small intestinal, (controlling) lets out essence, hematuria, blepharitis marginalis, acute mastitis, carbuncle on the back, scrofula, hemorrhoidal hamorrhage, and evacuation of pus is enriched blood, and controls and flutters damage, reuniting the fractured tendons and bones, deposit skin ulcer, and hemostasis is put on flesh, qualcomm meridian." 7. " Shanxi Chinese medicinal herbal ": " clearing away heat and cooling blood, controls toxic-heat and blood stasis, epistaxis, internal hemorrhoid with bleeding, the diseases such as pestilence."
Herba Rorippae: nature and flavor are pungent is cool.1. supplement to the Herbal: " acrid in the mouth, temperature, nontoxic." 2. " Kweiyang medicinal herbs among the people ": " is pungent, cool, nontoxic." 3. " Traditional Chinese Medicine in Sichuan will ": " is cool in nature.Bitter in the mouth is pungent, nontoxic." 4. Guangzhou army " conventional Chinese herbal medicine handbook ": " is sweet light, cool." function cures mainly heat clearing away, diuresis, invigorates blood circulation, and stimulates the menstrual flow.Cure cold, heat syndrome cough, pharyngalgia, measles is not easily sent out thoroughly, rheumatic arthritis, jaundice, edema, and furuncle swells, amenorrhea, traumatic injury.1. supplement to the Herbal: " remove cold air, cold for a long time in abdomen, diet does not disappear, and makes us eating." 2. " detailed outline ": " sharp chest and diaphragm, slit cold phlegm, cardiac and abdominal pain." 3. " classifying herbal ": " is controlled cutter and cuts axe wound, and rotten skin ulcer, granulation promoting, chews painting." 4. " south of the Five Ridges gather medicinal herbs record ": " and raw fish are decocted soup and take it, the heat in boning." 5. " Guizhou side among the people medicine collection ": " antipyretic diuresis.Control ascites, drench disease; Burn is controlled in external.Furunculosis is controlled in " 6. " conventional glossary of Herbs and Drugs among the people ": " external; Venting QI-blood for oral administration.Control women's breast sick, and control cough, jaundice." 7. " Kweiyang medicinal herbs among the people ": " heat-clearing and toxic substances removing, relieving cough and resolving phlegm.Dermatitis rhus is controlled in external, furuncle, carbuncle." 8. Guangzhou army " conventional Chinese herbal medicine handbook ": " clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.Cure cold heating, laryngopharynx swelling and pain, aphonia; Cough due to lung-heat, hemoptysis; Acute rheumatic arthritis; Edema." 9. " Fujian Chinese herbal medicine ": " dispelling wind expelling pathogenic factors from the exterior, regulating qi-flowing for harmonizing stomach."
Herba Hedyotis scabridae: nature and flavor are bitter, cool.1. " Nanning City's medicine will ": " sweet, cool, nontoxic." 2. " Yunnan Chinese herbal medicine ": " micro-bitterness, flat." function cures mainly clearing away heat and cooling blood, and spleen invigorating dehumidifies.Control ulcerative gingivitis, infantile malnutrition, rheumatic arthralgia, 1. " Nanning City's medicine will ": " clearing away heat from blood, reason ulcerative gingivitis, gingival abscess.Control infantile malnutrition excessive thirst, treating swelling and pain by traumatic injury." 2. " register planted by Guangxi medicine ": " leaf: removing heat from blood." 3. " Yunnan Chinese herbal medicine ": " wind-damp dispelling, strengthening the spleen and stomach."
Herba Boenninghauseniae Albiflorae: in the raw hillside of habitats distribution, sylvan life and shrubbery.Distribution southwest, south China, East China are to Taiwan and other places.Chemical analysis Boenninghausenia albiflora herb contains aromatic oil 0.25%, stem and leaf oil-containing 0.3%.Aerial parts contains globulariacitrin, bergapton, dictamine.The root of this product Japan mutation S.Suzuki, also containing dictamine, also containing matsukaze lactone in leaf.Nature and flavor " choosing of Yunnan Chinese herbal medicine ": " pungent light, cold.Belly pain is controlled in " 1. function cures mainly " will planted by middle traditional Chinese medicines ": " decoction.Leaf is mashed external application and is controlled scald." 2. " choosing of Yunnan Chinese herbal medicine ": " clearing away heat and cooling blood, relaxing muscles and tendons to promote blood circulation, antiinflammatory.Cure cold, pharyngolaryngitis, hepatitis, spitting of blood, epistaxis, lumbago, traumatic injury, ecchymoma."
Rhizoma begoniae pedatifidae: nature and flavor acid is flat.1. " classify herbal ": " sweet in the mouth is nontoxic." 2. " Traditional Chinese Medicine in Sichuan will ": " property is put down, and sour in the mouth is nontoxic." 3. " Jiangxi medical herbs ": " is cold in nature, sour in the mouth." function cures mainly expelling wind and activating blood circulation, diuretic, removing toxic substances.Dispelling the wind and dampness pathogens arthralgia, edema, hematuria, traumatic injury, snakebite.1. " classify herbal ": " harness the Yellow River swollen." 2. " Traditional Chinese Medicine in Sichuan will ": " can fall apart blood hemostasis.Control nephropathy general edema with yellowish skin, venom and women's scleritis, infantile malnutrition of heat type." 3. " Jiangxi medical herbs ": " expelling wind and activating blood circulation, inducing diuresis to remove edema."
Styrax: nature and flavor are pungent, temperature.1. " not Lu ": " sweet in the mouth, temperature, nontoxic." 2. " book on Chinese herbal medicine just ": " sweet in the mouth is pungent, warm in nature." return through entering lung, Liver Channel.1. " beautiful Chinese catalpa medicine solution ": " start with lunar lung, liver channel of foot-Jueyin." 2. " must join book on Chinese herbal medicine ": " enters meridian of Foot-TAI YIN." 3. " book on Chinese herbal medicine is new again ": " enters spleen, stomach two warp." function cures mainly sensible, wards off dirty, dissipating depression of QI, eliminating phlegm.Control soldier so to faint, expectorant heap soil or fertilizer over and around the roots is lost consciousness, infantile convulsion, pyrexial malaria, the sudden pain of trusted subordinate, scabies, chilblain.1. " not Lu ": " mainly ward off evil, pyrexial malaria ， Xian Chi.Go three worms, evil removing, make us without nightmare." 2. " book on Chinese herbal medicine just ": " parasite killing poison.Treat epilepsy, only QI rising in reverse order pain." 3. essentials of Matea Medica: " is walked to alter, sensible dissipating depression of QI, wards off all not gas just." 4. " beautiful Chinese catalpa medicine solution ": " inducing diuresis to remove edema, controls swollen ， Zhen Rush, QI-mass mass formed by blood stasis, mediation internal organs."
Concha Meretricis Seu Cyclinae: nature and flavor are salty; Cold nature.Return lung, kidney, stomach warp.Cure mainly removing heat from the lung and dissipating phlegm; Hard masses softening and resolving; Inducing diuresis to remove edema; Relieving gastric hyperacidity to alleviate stomachache; Sore removing dampness.Main phlegm-heat cough; Goiter; Sucutaneous nodule; Hypochondriac pain; Damp and hot edema; Stranguria with turbid discharge leukorrhagia; Stomachache pantothenic acid; Ecthyma eczema.
The Radix Aucklandiae: nature and flavor are worked hard, temperature.1. " herbal classic ": " acrid in the mouth, temperature." 2. Materia Medica of Decoction: " gas heat, acrid in the mouth is bitter, nontoxic." return through entering lung, liver, spleen channel.1. " Amplification on Materia Medica addendum ": " row Liver Channel." 2. " Thunder God concocts property of medicine solution ": " popular feeling, lung, liver, spleen, stomach, bladder the six channels." function cures mainly promoting the circulation of QI to relieve pain, warming middle-JIAO for easing the stomach.Control the invasion by pathogenic cold stagnation of QI, chest and abdomen swelling and pain, vomiting, has loose bowels, dysentery tenesmus, colic of cold type.1. " herbal classic ": " main pathogen, wards off malicious epidemic disease, Qiang Zhi, main pouring dew." 2. " not Lu ": " treats that gas is bad, partially cold in flesh; Main QI-insufficiency, sterilization, (controlling) pyrexial malaria, the essence of row medicine.It is swollen that " 3. Collective Notes to the Canon of Materia medica: " treats poison, and disappear bad odor.It is unbearably painful that " 4. " property of medicine opinion ": " controls woman's vim and vigour thorn heart heart, and end, wine takes it.Control several pained, cold air for many years, Xuan ringworm block, distending pain, unhappy by all heap soil or fertilizer over and around the roots adverses QI rushing upwards.Control cholera to vomit and diarrhoea, trusted subordinate's pestilence is stung." 5. " Japan hanako materia medica ": " controls all gas of trusted subordinate, antidiarrheal, cholera, dysentery, antiabortive, strengthening the spleen to promote digestion.Treat thin bad, bladder cold type of pain, vomiting and regurgitation." 6. Wang Haogu: " controls chong channel for sick, inverse gas pain in the abdomen.Main bladder oozes little constipation." 7. " explaining abstruseness of the canon of materia medica ": " reason hernia."
Folium Eucalypti Robustae: nature and flavor toil is flat.1. " south of the Five Ridges herbal ": " taste is micro-pungent puckery, and property is put down." 2. Guangzhou army " conventional Chinese herbal medicine handbook ": " micro-pungent micro-hardship, flat." function cures mainly heat-clearing and toxic substances removing.Cure cold, acute enteritis, dysentery, pyelonephritis, erysipelas, carbuncle, scalds, traumatic infection, ulcer of the lower limb, suppurative keratitis, atrophic rhinitis.1. " illustrated handbook planted by middle traditional Chinese medicines ": " control suppurative wound, the ulcer etc. that difficulty heals." 2. " south of the Five Ridges herbal ": " dispelling wind is antipyretic, anticorrosion antipruritic." 3. " Guangxi Chinese herbal medicine ": " heat-clearing and toxic substances removing, parasite killing is restrained.Control diarrhoea, dysentery, flu, treat carbuncle furuncle and eczema." 4. " Zhejiang conventional medical herbs among the people ": " cough-relieving, stomach invigorating, anthelmintic."
Herba Polygoni Perfoliati: [nature and flavor] are bitter is flat.1. " Wanbing Huichun, Curative Measures for All Diseases ": " sour in the mouth." 2. " the SHENGCAO property of medicine standby want ": " bitter in the mouth, property and." 3. " Nanning City's medicine will ": " acid, flat, nontoxic." 4. " Kweiyang medicinal herbs among the people ": " is bitter, cold, slightly poisonous." function cures mainly inducing diuresis to remove edema, heat clearing away, invigorates blood circulation, removing toxic substances.Harness the river swollen, jaundice, has loose bowels, malaria, dysentery, pertussis, stranguria with turbid discharge, erysipelas, scrofula, eczema, scabies.1. " the little knowledge of physics ": " control scrofula, also can preventing the attack (or recurrence) of malaria." 2. " the SHENGCAO property of medicine is standby to be wanted ": " antidiarrheal, leaching infantile malnutrition, furuncle, hemorrhoid, can fall apart poison.It is dysphagic that " 3. Wang An minister in ancient times's " will of gathering medicinal herbs ": " controls regurgitation of food from the stomach, malaria, spits blood, have blood in stool, sore throat, and food stagnation is loved, empty full abdominal distention, scrotum enlargement, Na in traumatic injury, carbuncle on the back furuncle, acute mastitis, puerperal edema all over." 4. " detailed outline is picked up any lost article from the road ": " controls tympanites, edema, mass in the abdomen, HUANGBAI(sic) subcutaneous ulcer, and malaria does not heal for a long time, lymphogranuloma inguinale inguinal bubo, traumatic injury, and all poisonous snakes hinder." 5. " Zhiwu Mingshi Tukao ": " promoting the circulation of blood gas, control stranguria with turbid discharge." 6. " Guizhou side's medicine among the people Ju ": " external is harnessed the Yellow River chickenpox." 7. " Nanning City's medicine will ": " convergence sterilization.Control dysentery, incised wound, eczema; Scabies is controlled in external." 8. " Traditional Chinese Medicine in Sichuan will ": " changes pipe granulation promoting.Control deficiency of vital energy giddy, asthma, look unfamiliar nebula, edema." 9. " east, Fujian book on Chinese herbal medicine ", " control dental caries." 10. " Chinese herbal medicine is commonly used in Shanghai ": " controls oedema due to nephritis, wind-fire acute conjunctivitis, leukorrhagia, sting."
Folium et cacumen Breyniae Fruticosae: Euphorbiaceae mountain, source paint stem platymiscium black flour tree Breynia fruticosa (L.) Hook. f., is used as medicine with root, leaf.The whole year can adopt, and clean section is dried.Property mildly bitter flavor is cool.Slightly poisonous.Function cures mainly heat-clearing and toxic substances removing, dissipating blood stasis, and pain relieving is antipruritic.Root: acute gastroenteritis, tonsillitis, bronchitis, lithangiuria, puerperal uterine contraction pain, rheumatic arthritis.Leaf: burn and scald is controlled in external, eczema, allergic dermatitis, skin itching, vaginitis.
Herba Houttuyniae: nature and flavor are pungent, cold.1. " not Lu ": " acrid in the mouth, tepor." 2. 《 Lv Cliff rock book on Chinese herbal medicine ": " cool in nature, nontoxic." 3. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " is cold in nature, and bitter in the mouth is pungent." 4. " detailed outline ": " is pungent, tepor." 5. " medical center bun is wanted ": " is sweet pungent salty." return through 1. " Bencao Jingshu ": " enters meridian of Hand-TAI YIN." 2. " book on Chinese herbal medicine is new again ": " enters liver, lung two warp." function cures mainly heat-clearing and toxic substances removing, inducing diuresis to remove edema.Control pneumonia, lung abscess, hematodiarrhoea, malaria, edema, gonorrhea, leucorrhea, carbuncle, hemorrhoid, proctoptosis, eczema, tinea alba, scabies.1. " not Lu ": " main earwig is drowned skin ulcer.Simmer in " 2. " Japan hanako materia medica ": " phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle cylinder, deposited malignant boil is bald in vain." 3. 《 Lv Cliff rock book on Chinese herbal medicine ": " control greatly the vexed unrest of heatstroke latent heat, syncope." 4. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " controls lung abscess cough band pus and blood, and expectorant has stench, large intestine pyretic toxicity, treats hemorrhoid." 5. " detailed outline ": " dispel the heat malicious carbuncle, skin ulcer hemorrhoid proctoptosis ， Duan Malaria disease, separates Nao poison." 6. " medical center bun is wanted ": " row water, assaults fortified position, goes miasma, expelling summer-heat.Treat snakeworm poison, control beriberi, carbuncle of bursting, blood stasis removing blood." 7. Chen Nian ancestral: " is raw smashes stopping vomiting blood." 8. " classifying herbal ": " controls five types of stranguria, consumer edema, and go food stagnation, tonify deficiency is weak, and disappear expansion." 9. " south of the Five Ridges gather medicinal herbs record ": " leaf: apply vicious large carbuncle(disease), can sterilize; Decoction energy remuval of damp and hot, controls dysentery." 10. " modern Practical Chinese medicinal ": " leave: warm external application, be vesicatory, skin ulcer tinea can be controlled.All scabies swelling, eczema, lumbago etc. can be done to bathe soup stock.Its root is chewed in life, prevents the angina pectoris attacks of coronary heart disease.The emetic that " " illustrated handbook planted by middle traditional Chinese medicines ": " can take poison do first aid." Guangzhou air force " conventional Chinese herbal medicine handbook ": " eliminating inflammation and expelling toxin, inducing diuresis to remove edema.Control upper respiratory tract infection, lung abscess, urinary tract inflammation and other position suppurative inflammation, venom." Guangzhou army " conventional Chinese herbal medicine handbook ": " heat-clearing and toxic substances removing.Control mastitis, cellulitis, otitis media, enteritis."
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 pharmaceutical composition 1
The Radix Rehmanniae 15 weight portion, Radix Scrophulariae 20 weight portion, Cortex Moutan 25 weight portion, Radix Arnebiae (Radix Lithospermi) 18 weight portion, Folium Sennae 7 weight portion, Aloe 19 weight portion, Semen Pruni 18 weight portion, Ramulus Mori 19 weight portion, Caulis Trachelospermi 22 weight portion, geranium 25 weight portion, Poria 23 weight portion, Semen Coicis 28 weight portion, Stigma Maydis 30 weight portion, calabash 25 weight portion, Herba Capsellae 28 weight portion, Medulla Tetrapanacis 25 weight portion, Folium Pyrrosiae 20 weight portion, Medulla Junci 14 weight portion, Herba Aristolochiae 22 weight portion, Pericarpium Arecae 16 weight portion, Radix Et Rhizoma Nardostachyos 12 weight portion, fevervine 20 weight portion, Fructus Oryzae Germinatus 18 weight portion, Radix Rhapontici 18 weight portion, Herba Rorippae 25 weight portion, Herba Hedyotis scabridae 18 weight portion, Herba Boenninghauseniae Albiflorae 19 weight portion, Rhizoma begoniae pedatifidae 16 weight portion, Styrax 22 weight portion and Concha Meretricis Seu Cyclinae 14 weight portion.
Its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 times, mixture is the ethanol of 84%, be heated to boiling reflux 2 hours, filter, adopt percolation with the speed of 1ml per minute slowly percolation, collect percolate, when being evaporated to 55 DEG C subsequently under vacuum 0.06Mpa, relative density is the mastic of 1.02, spraying dry, the inlet temperature 165 DEG C of spray dryer, leaving air temp 85 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.1 times and 0.1 times in the dried cream powder obtained, makes granule, in 40 DEG C of dryings, obtains granule.
Embodiment 2 pharmaceutical composition 2
The Radix Rehmanniae 15 weight portion, Radix Scrophulariae 20 weight portion, Cortex Moutan 25 weight portion, Radix Arnebiae (Radix Lithospermi) 18 weight portion, Folium Sennae 7 weight portion, Aloe 19 weight portion, Semen Pruni 18 weight portion, Ramulus Mori 19 weight portion, Caulis Trachelospermi 22 weight portion, geranium 25 weight portion, Poria 23 weight portion, Semen Coicis 28 weight portion, Stigma Maydis 30 weight portion, calabash 25 weight portion, Herba Capsellae 28 weight portion, Medulla Tetrapanacis 25 weight portion, Folium Pyrrosiae 20 weight portion, Medulla Junci 14 weight portion, Herba Aristolochiae 22 weight portion, Pericarpium Arecae 16 weight portion, Radix Et Rhizoma Nardostachyos 12 weight portion, fevervine 20 weight portion, Fructus Oryzae Germinatus 18 weight portion, Radix Rhapontici 18 weight portion, Herba Rorippae 25 weight portion, Herba Hedyotis scabridae 18 weight portion, Herba Boenninghauseniae Albiflorae 19 weight portion, Rhizoma begoniae pedatifidae 16 weight portion, Styrax 22 weight portion, Concha Meretricis Seu Cyclinae 14 weight portion, the Radix Aucklandiae 14 weight portion, Folium Eucalypti Robustae 16 weight portion, Herba Polygoni Perfoliati 20 weight portion, Folium et cacumen Breyniae Fruticosae 15 weight portion and Herba Houttuyniae 16 weight portion.
Its preparation method comprises the following steps:
The first step, by Ramulus Mori, Caulis Trachelospermi, geranium and Poria mixing, add relative to mixture 3 times amount determining alcohol be 75% alcohol reflux 2 times, each 2 hours, filter, filtrate merges, and reclaim ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.20, for subsequent use;
Second step, is mixed in proportion described for residue raw medicinal material, adds relative to mixture 4 times of water gagings, boils 2 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.21;
3rd step, the mastic mixing that the first step, second step are obtained, 75 DEG C of reduced vacuum dryings, get dry extract powder;
4th step, carries out mixing by described dried cream powder and starch and processes, obtain mastic mixture; Described mastic and the weight ratio of starch are 1: 0.01; Described mastic mixture is carried out pelletization treatment, dried, the mastic compound particles obtained;
5th step, described mastic compound particles and the Pulvis Talci of 1 times amount, the magnesium stearate of 0.15 times amount are carried out successively mixing processes, tabletting process, Cotton seeds, obtain Chinese medicine preparation tablet finished product.
The toxicity test of pharmaceutical composition
1, trial drug: by Radix Rehmanniae 15g, Radix Scrophulariae 20g, Cortex Moutan 25g, Radix Arnebiae (Radix Lithospermi) 18g, Folium Sennae 7g, Aloe 19g, Semen Pruni 18g, Ramulus Mori 19g, Caulis Trachelospermi 22g, geranium 25g, Poria 23g, Semen Coicis 28g, Stigma Maydis 30g, calabash 25g, Herba Capsellae 28g, Medulla Tetrapanacis 25g, Folium Pyrrosiae 20g, Medulla Junci 14g, Herba Aristolochiae 22g, Pericarpium Arecae 16g, Radix Et Rhizoma Nardostachyos 12g, fevervine 20g, Fructus Oryzae Germinatus 18g, Radix Rhapontici 18g, Herba Rorippae 25g, Herba Hedyotis scabridae 18g, Herba Boenninghauseniae Albiflorae 19g, Rhizoma begoniae pedatifidae 16g, purple casserole is put in Styrax 22g and Concha Meretricis Seu Cyclinae 14g mixing, add clear water, to clear water dipped medical material upper surface 4cm, soak 8 hours, be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 50 minutes dosage to medicinal liquid be slowly 300ml, filters, obtain filtrate a, for subsequent use, residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 3cm, soaks 10 hours, be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 35 minutes dosage to medicinal liquid be slowly 100ml, filters, obtain filtrate b, and filtrate a and filtrate b mixing can be obtained decoction.
2, test method: select 30 healthy mices, female, each 15 of hero, take trial drug as object, dose design is first phase in every 5 days, each issue dosage is respectively 0.10LD50,0.15LD50,0.25LD50,0.3LD 50,0.35LD50, the LD 50 that is female, male mice of this sample be 6000m part/k part BW (five dosage is 600,900,1500,1800,2100m part/k part BW).Within every 5 days, weigh once, adjustment dosage, by 0.25ml/10 part BW per os gavage.After 20 days, animal occurs without death condition, off-test, and by ascending-dose to tested material after 20 days, female, buck all occurs without death condition.Show, pharmaceutical composition of the present invention is not causing toxicity.
Contrast test
Cultivation pig has 1000 to Heze City one pig farm in 2013, and wherein the symptom of pig malignant edema appears in about 500 pigs: common eyelid, face, sometimes swelling under cervical region and abdomen; The auscultation of swelling position is without crepitation; Cut open inspection thickened stomach wall, mucous layer is separated with muscle layer, and edema layer can reach 1 ~ 2 cm.
Select 210 sick pigs wherein to carry out isolation experiment, be divided into 3 groups at random, embodiment 1 group, embodiment 2 groups and western medicine group, often organize 70, environment of feeding is consistent.
Embodiment 1 group: adopt the granule of the embodiment of the present invention 1 to treat.Granule is mixed in conventional feed according to the ratio of 3:100 and normally feeds, feed and carry out 7 days.
Embodiment 2 groups: adopt the tablet of the embodiment of the present invention 2 to treat.Be mixed in conventional feed according to the ratio of 3:100 after tablet is smashed to pieces and normally feed, feed and carry out 7 days.
Western medicine group: adopt penicillin to treat.Penicillin is carried out intramuscular injection according to 2,400,000 units, normally feeds, feed and carry out 7 days.
Diagnosis: mostly 1. be and distribute, sex, age and kind and this disease have nothing to do; 2. manyly after having wound (bite, wound), castration etc., locally there is inflammatory edema; 3. edematous site, the initial stage by being pressed with depression, after have crepitation; Cut edema, visible reddish yellow or bronzing foam, and there is the smelly liquid of acid; 4., after gastric mucosa infects, there is swelling and thicken, formed so-called " rubber stomach "; 5. as puerperal infection, pelvic cavity serous coat and perivaginal organize hemorrhage and edema; 6. take edematous fluid, slough or liver,spleen,kidney, lung, painstaking effort smear, Gram-positive, thalline is micro-curved in long filament shape, and spore is larger than thalline, in oval, is positioned at thalline central authorities or near-end.Common eyelid, face, sometimes swelling under cervical region and abdomen; The auscultation of swelling position is without crepitation; Cut open inspection thickened stomach wall, mucous layer is separated with muscle layer, and edema layer can reach 1 ~ 2 cm.
Curative effect is passed judgment on: cure: transference cure, recovers normal; Effective: partial symptoms alleviates, basic recovery is normal; Invalid: disease is without disappearance or alleviate, or dead.
Therapeutic outcome
Table 1 is the treatment situation contrast of each group
As can be seen from Table 1, the healing of embodiment 1 group and embodiment 2 groups and be effectively all better than western medicine group, can illustrate, pharmaceutical composition of the present invention, treat in pig malignant edema, good effect, determined curative effect.
Table 2 is the healing of each group and the treatment time contrast of significant figure
As can be seen from Table 2, just there is therapeutic effect in the healing of the pig of embodiment 1 group and embodiment 2 groups and significant figure at short notice, quick western medicine group, can learn, pharmaceutical composition of the present invention, treatment pig malignant edema, and treatment time is short, and treatment fast.
In sum, pharmaceutical composition of the present invention, treatment pig malignant edema, therapeutic effect is good, determined curative effect, and treatment is fast.
Case: in June, 2013, there is the symptom of pig malignant edema in about 300, pig farm, one, Linyi pig: eyelid, face, sometimes swelling under cervical region and abdomen; The auscultation of swelling position is without crepitation; Cut open inspection thickened stomach wall, mucous layer is separated with muscle layer, and edema layer can reach 1 ~ 2 cm.Be diagnosed as pig malignant edema.Select 100 ill pigs, adopt the tablet of embodiments of the invention 2 to treat, 3:100 is mixed in conventional feed and carries out diet, feeds through 7 days, and cure 99, cure rate reaches 99%.Follow-up is not recurred.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (10)

1. one kind is used for the treatment of the pharmaceutical composition of pig malignant edema, it is characterized in that, described pharmaceutical composition comprises following raw medicinal material: the Radix Rehmanniae, Radix Scrophulariae, Cortex Moutan, Radix Arnebiae (Radix Lithospermi), Folium Sennae, Aloe, Semen Pruni, Ramulus Mori, Caulis Trachelospermi, geranium, Poria, Semen Coicis, Stigma Maydis, calabash, Herba Capsellae, Medulla Tetrapanacis, Folium Pyrrosiae, Medulla Junci, Herba Aristolochiae, Pericarpium Arecae, Radix Et Rhizoma Nardostachyos, fevervine, Fructus Oryzae Germinatus, Radix Rhapontici, Herba Rorippae, Herba Hedyotis scabridae, Herba Boenninghauseniae Albiflorae, Rhizoma begoniae pedatifidae, Styrax and Concha Meretricis Seu Cyclinae.
2. the pharmaceutical composition being used for the treatment of pig malignant edema according to claim 1, is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix Rehmanniae 10-25 weight portion, Radix Scrophulariae 10-20 weight portion, Cortex Moutan 13-25 weight portion, Radix Arnebiae (Radix Lithospermi) 10-24 weight portion, Folium Sennae 7-12 weight portion, Aloe 10-20 weight portion, Semen Pruni 14-24 weight portion, Ramulus Mori 10-25 weight portion, Caulis Trachelospermi 12-26 weight portion, geranium 12-25 weight portion, Poria 10-23 weight portion, Semen Coicis 13-28 weight portion, Stigma Maydis 15-30 weight portion, calabash 15-25 weight portion, Herba Capsellae 14-28 weight portion, Medulla Tetrapanacis 15-25 weight portion, Folium Pyrrosiae 10-20 weight portion, Medulla Junci 10-20 weight portion, Herba Aristolochiae 12-24 weight portion, Pericarpium Arecae 10-20 weight portion, Radix Et Rhizoma Nardostachyos 10-20 weight portion, fevervine 12-22 weight portion, Fructus Oryzae Germinatus 10-24 weight portion, Radix Rhapontici 10-23 weight portion, Herba Rorippae 10-25 weight portion, Herba Hedyotis scabridae 13-27 weight portion, Herba Boenninghauseniae Albiflorae 14-26 weight portion, Rhizoma begoniae pedatifidae 10-26 weight portion, Styrax 12-26 weight portion and Concha Meretricis Seu Cyclinae 10-20 weight portion.
3. the pharmaceutical composition being used for the treatment of pig malignant edema according to claim 1 and 2, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: the Radix Rehmanniae 15 weight portion, Radix Scrophulariae 20 weight portion, Cortex Moutan 25 weight portion, Radix Arnebiae (Radix Lithospermi) 18 weight portion, Folium Sennae 7 weight portion, Aloe 19 weight portion, Semen Pruni 18 weight portion, Ramulus Mori 19 weight portion, Caulis Trachelospermi 22 weight portion, geranium 25 weight portion, Poria 23 weight portion, Semen Coicis 28 weight portion, Stigma Maydis 30 weight portion, calabash 25 weight portion, Herba Capsellae 28 weight portion, Medulla Tetrapanacis 25 weight portion, Folium Pyrrosiae 20 weight portion, Medulla Junci 14 weight portion, Herba Aristolochiae 22 weight portion, Pericarpium Arecae 16 weight portion, Radix Et Rhizoma Nardostachyos 12 weight portion, fevervine 20 weight portion, Fructus Oryzae Germinatus 18 weight portion, Radix Rhapontici 18 weight portion, Herba Rorippae 25 weight portion, Herba Hedyotis scabridae 18 weight portion, Herba Boenninghauseniae Albiflorae 19 weight portion, Rhizoma begoniae pedatifidae 16 weight portion, Styrax 22 weight portion and Concha Meretricis Seu Cyclinae 14 weight portion.
4. the pharmaceutical composition being used for the treatment of pig malignant edema according to any one of claim 1-3, is characterized in that, described pharmaceutical composition also comprises the Radix Aucklandiae, Folium Eucalypti Robustae, Herba Polygoni Perfoliati, Folium et cacumen Breyniae Fruticosae and Herba Houttuyniae.
5. the pharmaceutical composition being used for the treatment of pig malignant edema according to any one of claim 1-4, is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix Rehmanniae 10-25 weight portion, Radix Scrophulariae 10-20 weight portion, Cortex Moutan 13-25 weight portion, Radix Arnebiae (Radix Lithospermi) 10-24 weight portion, Folium Sennae 7-12 weight portion, Aloe 10-20 weight portion, Semen Pruni 14-24 weight portion, Ramulus Mori 10-25 weight portion, Caulis Trachelospermi 12-26 weight portion, geranium 12-25 weight portion, Poria 10-23 weight portion, Semen Coicis 13-28 weight portion, Stigma Maydis 15-30 weight portion, calabash 15-25 weight portion, Herba Capsellae 14-28 weight portion, Medulla Tetrapanacis 15-25 weight portion, Folium Pyrrosiae 10-20 weight portion, Medulla Junci 10-20 weight portion, Herba Aristolochiae 12-24 weight portion, Pericarpium Arecae 10-20 weight portion, Radix Et Rhizoma Nardostachyos 10-20 weight portion, fevervine 12-22 weight portion, Fructus Oryzae Germinatus 10-24 weight portion, Radix Rhapontici 10-23 weight portion, Herba Rorippae 10-25 weight portion, Herba Hedyotis scabridae 13-27 weight portion, Herba Boenninghauseniae Albiflorae 14-26 weight portion, Rhizoma begoniae pedatifidae 10-26 weight portion, Styrax 12-26 weight portion, Concha Meretricis Seu Cyclinae 10-20 weight portion, Radix Aucklandiae 10-20 weight portion, Folium Eucalypti Robustae 12-24 weight portion, Herba Polygoni Perfoliati 12-20 weight portion, Folium et cacumen Breyniae Fruticosae 10-20 weight portion and Herba Houttuyniae 10-18 weight portion.
6. the pharmaceutical composition being used for the treatment of pig malignant edema according to any one of claim 1-5, is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: the Radix Rehmanniae 15 weight portion, Radix Scrophulariae 20 weight portion, Cortex Moutan 25 weight portion, Radix Arnebiae (Radix Lithospermi) 18 weight portion, Folium Sennae 7 weight portion, Aloe 19 weight portion, Semen Pruni 18 weight portion, Ramulus Mori 19 weight portion, Caulis Trachelospermi 22 weight portion, geranium 25 weight portion, Poria 23 weight portion, Semen Coicis 28 weight portion, Stigma Maydis 30 weight portion, calabash 25 weight portion, Herba Capsellae 28 weight portion, Medulla Tetrapanacis 25 weight portion, Folium Pyrrosiae 20 weight portion, Medulla Junci 14 weight portion, Herba Aristolochiae 22 weight portion, Pericarpium Arecae 16 weight portion, Radix Et Rhizoma Nardostachyos 12 weight portion, fevervine 20 weight portion, Fructus Oryzae Germinatus 18 weight portion, Radix Rhapontici 18 weight portion, Herba Rorippae 25 weight portion, Herba Hedyotis scabridae 18 weight portion, Herba Boenninghauseniae Albiflorae 19 weight portion, Rhizoma begoniae pedatifidae 16 weight portion, Styrax 22 weight portion, Concha Meretricis Seu Cyclinae 14 weight portion, the Radix Aucklandiae 14 weight portion, Folium Eucalypti Robustae 16 weight portion, Herba Polygoni Perfoliati 20 weight portion, Folium et cacumen Breyniae Fruticosae 15 weight portion and Herba Houttuyniae 16 weight portion.
7. the pharmaceutical composition being used for the treatment of pig malignant edema according to any one of claim 1-6, is characterized in that, the dosage form of described pharmaceutical composition is granule, and its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 3 ~ 5 times, mixture is the ethanol of 84% ~ 90%, be heated to boiling reflux 2 ~ 4 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 55 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.02 ~ 1.08, spraying dry, the inlet temperature 165 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.1 ~ 0.3 times and 0.1 ~ 0.3 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.
8. the pharmaceutical composition being used for the treatment of pig malignant edema according to any one of claim 1-6, is characterized in that, the dosage form of described pharmaceutical composition is tablet, and its preparation method comprises the following steps:
The first step, by Ramulus Mori, Caulis Trachelospermi, geranium and Poria mixing, add relative to mixture 3 ~ 5 times amount determining alcohol be 75% ~ 85% alcohol reflux 2 ~ 4 times, each 2 ~ 3 hours, filter, filtrate merges, reclaim ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.20 ~ 1.22, for subsequent use;
Second step, is mixed in proportion described for residue raw medicinal material, adds relative to mixture 2 ~ 4 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.21 ~ 1.24;
3rd step, the mastic mixing that the first step, second step are obtained, 75 DEG C ~ 85 DEG C reduced vacuum dryings, get dry extract powder;
4th step, carries out mixing by described dried cream powder and starch and processes, obtain mastic mixture; Described mastic and the weight ratio of starch are 1: 0.01 ~ 0.02; Described mastic mixture is carried out pelletization treatment, dried, the mastic compound particles obtained;
5th step, described mastic compound particles and the Pulvis Talci of 1 ~ 3 times amount, the magnesium stearate of 0.15 ~ 0.3 times amount are carried out successively mixing processes, tabletting process, Cotton seeds, obtain Chinese medicine preparation tablet finished product.
9. the preparation method being used for the treatment of the pharmaceutical composition of pig malignant edema as described in any one of claim 1-6, is characterized in that, the dosage form of described pharmaceutical composition is granule, and its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 3 ~ 5 times, mixture is the ethanol of 84% ~ 90%, be heated to boiling reflux 2 ~ 4 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 55 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.02 ~ 1.08, spraying dry, the inlet temperature 165 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.1 ~ 0.3 times and 0.1 ~ 0.3 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.
10. the preparation method being used for the treatment of the pharmaceutical composition of pig malignant edema as described in any one of claim 1-6, is characterized in that, the dosage form of described pharmaceutical composition is tablet, and its preparation method comprises the following steps:
The first step, by Ramulus Mori, Caulis Trachelospermi, geranium and Poria mixing, add relative to mixture 3 ~ 5 times amount determining alcohol be 75% ~ 85% alcohol reflux 2 ~ 4 times, each 2 ~ 3 hours, filter, filtrate merges, reclaim ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.20 ~ 1.22, for subsequent use;
Second step, is mixed in proportion described for residue raw medicinal material, adds relative to mixture 2 ~ 4 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.21 ~ 1.24;
3rd step, the mastic mixing that the first step, second step are obtained, 75 DEG C ~ 85 DEG C reduced vacuum dryings, get dry extract powder;
4th step, carries out mixing by described dried cream powder and starch and processes, obtain mastic mixture; Described mastic and the weight ratio of starch are 1: 0.01 ~ 0.02; Described mastic mixture is carried out pelletization treatment, dried, the mastic compound particles obtained;
5th step, described mastic compound particles and the Pulvis Talci of 1 ~ 3 times amount, the magnesium stearate of 0.15 ~ 0.3 times amount are carried out successively mixing processes, tabletting process, Cotton seeds, obtain Chinese medicine preparation tablet finished product.
CN201410694470.2A 2014-11-27 2014-11-27 Pharmaceutical composition for treating porcine malignant edema and preparation method thereof Withdrawn CN104474366A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101108241A (en) * 2007-07-13 2008-01-23 徐金山 Medicament for improving pigling survival rate and method of manufacturing the same
CN103656133A (en) * 2012-09-13 2014-03-26 夏文灏 Preparation method of traditional Chinese medicine prescription for treating baby pig edema

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101108241A (en) * 2007-07-13 2008-01-23 徐金山 Medicament for improving pigling survival rate and method of manufacturing the same
CN103656133A (en) * 2012-09-13 2014-03-26 夏文灏 Preparation method of traditional Chinese medicine prescription for treating baby pig edema

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