CN104474083A - Traditional Chinese medicine compound preparation for treating porcine reproductive and respiratory syndrome - Google Patents
Traditional Chinese medicine compound preparation for treating porcine reproductive and respiratory syndrome Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/185—Magnoliopsida (dicotyledons)
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Abstract
The invention relates to a medicine for treating porcine reproductive and respiratory syndrome and particularly relates to a traditional Chinese medicine compound preparation for treating porcine reproductive and respiratory syndrome. The traditional Chinese medicine compound preparation is prepared from the following medicinal raw materials in a certain proportion: Schizonepeta, divaricate saposhnikovia roots, radix bupleuri, common hogfenneI roots, notopterygium roots, radix angelicae pubescentis, ginseng rootlets, burdocks, fructus aurantii, poria cocos, platycodon grandiflorum, ligusticum wallichii, liquorice, mint, scutellaria baicalensis and radices trichosanthis. The traditional Chinese medicine compound preparation provided by the invention mainly has the effects of clearing heat and expelling damp, reducing lung heat and preventing asthma and invigorating stomach and helping digestion, and not only has an obvious curative effect for treating porcine reproductive and respiratory syndrome, but also further has a good promoting effect on growth performance of piglets.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of pig blue-ear disease, particularly a kind of compound Chinese medicinal preparation for the treatment of pig blue-ear disease.
Background technology
Highly pathogenic PRRS is the acute highly infective epidemic disease of one caused by porcine reproductive and respiratory syndrome virus (PRRSV), due to the easily variation of PRRSV virus, and its virulence can be caused to strengthen and cause new popular and morbidity, the features such as thus performance morbidity is anxious, popular extensively, fatality rate is high, control is difficult, economic loss is large, bring heavy losses to China's pig industry.From highly pathogenic PRRS in 2006 since China breaks out, many pig farms, in order to prevent morbidity, usually use pig blue-ear disease vaccine and veterinary drug and are that people bring comparatively considerable economic benefit.But, cause the instability of vaccine effect due to the variation of virus, bring great risk to pig farm, and use antibiotic effect poor.Along with growth in the living standard, the prescription of people to livestock products is more and more higher, many researcheres are pointed out to limit antibiotic a large amount of use in Animal husbandry production, and the feed additive therefore developing substitute antibiotics and chemical synthetic drug just becomes the focus of research both at home and abroad.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of compound Chinese medicinal preparation for the treatment of pig blue-ear disease, and said preparation not only has significant therapeutic effect to pig blue-ear disease, and also has good facilitation to piglet growth performance.
Technical problem to be solved by this invention is achieved by the following technical programs:
Treat a compound Chinese medicinal preparation for pig blue-ear disease, its crude drug is made up of the component of following parts by weight:
Herba Schizonepetae 4 ~ 8 parts, Radix Saposhnikoviae 8 ~ 12 parts, Radix Bupleuri 4 ~ 8 parts, Radix Peucedani 4 ~ 8 parts, Rhizoma Et Radix Notopterygii 4 ~ 8 parts, Radix Angelicae Pubescentis 4 ~ 8 parts, Leptoradix Ginseng 4 ~ 8 parts, Fructus Arctii 4 ~ 8 parts, Fructus Aurantii 4 ~ 8 parts, 4 ~ 8 parts, Poria, Radix Platycodonis 4 ~ 8 parts, Rhizoma Chuanxiong 4 ~ 8 parts, 4 ~ 8 parts, Radix Glycyrrhizae, Herba Menthae 4 ~ 8 parts, Radix Scutellariae 4 ~ 8 parts, Radix Trichosanthis 4 ~ 8 parts.
Preferably, the crude drug of the compound Chinese medicinal preparation of this treatment pig blue-ear disease is made up of the component of following parts by weight:
Herba Schizonepetae 6 parts, Radix Saposhnikoviae 10 parts, Radix Bupleuri 6 parts, Radix Peucedani 6 parts, Rhizoma Et Radix Notopterygii 6 parts, Radix Angelicae Pubescentis 6 parts, Leptoradix Ginseng 6 parts, Fructus Arctii 6 parts, Fructus Aurantii 6 parts, 6 parts, Poria, Radix Platycodonis 6 parts, Rhizoma Chuanxiong 6 parts, 6 parts, Radix Glycyrrhizae, Herba Menthae 6 parts, Radix Scutellariae 6 parts, Radix Trichosanthis 6 parts.
Further, the dosage form of described compound Chinese medicinal preparation is powder.
Said preparation processing method can be conventional directly grind to form fine powder.Also can be that solvent extracts effective ingredient, concentrated add adjuvant again and obtain fine powder.
Gained preparation is mixed by weight add in daily ration and use to pig feed.
The present invention has following beneficial effect:
Crude drug of the present invention is made up of by a certain percentage Herba Schizonepetae, Radix Saposhnikoviae, Radix Bupleuri, Radix Peucedani, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Leptoradix Ginseng, Fructus Arctii, Fructus Aurantii, Poria, Radix Platycodonis, Rhizoma Chuanxiong, Radix Glycyrrhizae, Herba Menthae, Radix Scutellariae, Radix Trichosanthis, Main Function is clearing heat and expelling damp, fall that lung is relievingd asthma, invigorating the stomach and promoting digestion, not only to pig blue-ear disease, there is significant therapeutic effect, and also have good facilitation to piglet growth performance.
Accompanying drawing explanation
Fig. 1 is that piglet increases day by day multigraph.
Fig. 2 is the effect diagram that Chinese medicinal formulae is searched for food to piglet.
Fig. 3 is the effect diagram of Chinese medicinal formulae to piglet health status.
Fig. 4 is the effect diagram of Chinese medicinal formulae to piglet growth situation.
Detailed description of the invention
Below in conjunction with drawings and Examples, the present invention will be described in detail.
Embodiment 1
Treat a compound Chinese medicinal preparation for pig blue-ear disease, crude drug is made up of the component of following parts by weight:
Herba Schizonepetae 6 parts, Radix Saposhnikoviae 10 parts, Radix Bupleuri 6 parts, Radix Peucedani 6 parts, Rhizoma Et Radix Notopterygii 6 parts, Radix Angelicae Pubescentis 6 parts, Leptoradix Ginseng 6 parts, Fructus Arctii 6 parts, Fructus Aurantii 6 parts, 6 parts, Poria, Radix Platycodonis 6 parts, Rhizoma Chuanxiong 6 parts, 6 parts, Radix Glycyrrhizae, Herba Menthae 6 parts, Radix Scutellariae 6 parts, Radix Trichosanthis 6 parts.
The preparation method of this compound preparation is conventional directly grind to form fine powder, is first cut into the fritter of long 3-5cm, is milled to fine-powdered and crosses 60 mesh sieves by above-mentioned raw materials medicine.
Said preparation eating method adds in daily ration for directly mixing by weight.
Below by test, effect of the present invention is described.
one, the therapeutic effect of pig blue-ear disease is tested
1 materials and methods
1.1 herbal prescriptions: the herbal component of this test adopts embodiment 1 prescription and preparation method.
Contrast medicament: tylosin+herd happy health (sulfanilamide pregnancy+Sulfamonomethoxine (TMP)), wherein tylosin is produced by Huangyan, Zhejiang animal pharmaceutical factory, herds happy health (Compound Sulfachorpyrdazine Sodium Powder+trimethoprim (TMP)): Chinanimal Nanjing Veterinary Drugs Co., Ltd..
1.2 prophylactic tria methods
(1) experimental animal divides group selection 1 to be detected as negative child care pig farm through reproductive and respiratory syndrome antiviral antibody, therefrom selects 30 age in days piglet 204.Principle that is close by body weight, male and female half and half is divided into 4 process at random, each process 3 repetition, each repetition 17 piglets.
(2) prevention treatment the 1st group is not administration group, and 2-4 group is drug test group.Wherein daily ration matched group based on first group, daily ration+western medicine group based on second group, the embodiment 1 compound Chinese herb prescription of daily ration+0.3 % percentage by weight based on 3rd group, the embodiment 1 compound Chinese herb prescription of daily ration+0.6 % percentage by weight based on the 4th group.
(3) observational technique was from Continuous Observation from November 9th, 2012 throws something and feeds 30 days, and every morning, afternoon respectively observe once, and record upgrowth situation, strong young number, morbidity pig number, pathogenic process etc.
(4) all test piglets of feeding environment control all carry out feeding and management in identical condition.Duration of test keep colony house dry, clean, ventilate, feed, to drink water and feeding and management is carried out according to a conventional method, be consistent as far as possible.
1.3 effect criterion
Effectively (survival): after piglet does not fall ill completely or falls ill, symptom is comparatively light, rehabilitation voluntarily within the observation period; Effective (health): live pig does not fall ill completely; Invalid (death): live pig falls ill, and dead or not rehabilitation voluntarily within the observation period.In order to statistical facility, in not administration group piglet depending on its disease a situation arises also with reference to above-mentioned standard carry out statistics sort out.
2 results and analysis
2.1 susceptible process observation
Between 9 days-December November in 2012 feeding period on the 9th, most of piglet robust growth.The 13rd day piglet after feeding occurs susceptible.November 21, piglet occurs that high heat (about 40.5 DEG C), dyspnea (in ventral breathing), spirit are highly depressed, drowsiness, can not lie prostrate, feed intake obviously descends degradation symptom.Continue to feed according to the feeding of Chinese medicine formula processing scheme; 25, piglet spirit slightly took a turn for the better, and former do not have appetitive pig to start energy lack of appetite amount feedstuff.November 26, the state of an illness takes a turn for the better further, and affected pig is energy proper motion in hurdle, and feed intake increases, and take temperature slightly declines, but still maintains between 39.7-40.8 DEG C.Method continues to feed like this, and 27-28 day in November, the symptoms such as cough, dyspnea alleviate, and skin color and defecation are close to normal, and body temperature is still higher.Now on the basis that such scheme is fed, add " drinking-water medication " by 3 times/d.November 29, morbidity piglet substantially recover normal, only have part occur morbidity and dead.Wherein piglet death toll 1-4 group is respectively 15,6,5 and 2.
The preventive effect of 2.2 pairs of piglet survivals
Add the prophylactic tria of Chinese medicine formula to highly pathogenic PRRS in foodstuff and the results are shown in Table 1.As can be seen from Table 1, the sickness rate of Chinese medicine formula test piglet is extremely remarkable in not administration group (sick 2=10.05, P<0.01), mortality rate is also extremely remarkable in not administration group (dead 2=17.71, P<0.01), show that Chinese medicine formula all has good preventive effect to highly pathogenic PRRS.Table 1 also shows simultaneously, Western medicine prevention highly pathogenic PRRS successful.
2.3 impacts on piglet growth situation
Chinese medicine formula to the effect of piglet growth situation in table 1.As shown in Table 1, Chinese medicine formula has good facilitation to piglet growth.Wherein the survival number of 0.6% Chinese herbal medicine group, 0.3% Chinese herbal medicine group, strong pig number, strong pig rate are all extremely significantly better than non-administered group, compared with classical Western medicine, 0.6% Chinese herbal medicine group is also significantly higher than classical Western medicine group, and the strong pig number of classical Western medicine group, strong pig rate also reach significant difference compared with non-administered group.
Table 1 Chinese medicine formula is to the prophylactic tria effect (unit: head, %) of highly pathogenic PRRS
2.4 various dose are to the preventive effect of piglet
In drug treating group, effective percentage and the obvious effective rate of 0.3% Chinese herbal medicine additive prevention highly pathogenic PRRS and classical veterinary drug TMP suitable (effective 2=6.90, P<0.05); And the effective percentage of 0.6% Chinese herbal medicine additive prevention highly pathogenic PRRS and obvious effective rate are all significantly higher than classical veterinary drug TMP (effective 2=6.90, P<0.05; Effective 2=6.09, P<0.05), show that 0.6% Chinese herbal medicine additive is obviously better than classical veterinary drug TMP to the preventive effect of highly pathogenic PRRS.
two, to the test of piglet growth performance
1 materials and methods
1.1 material
1.1.1 experimental animal and feeding and management
This test and Selection is at our company's pig breeding farm.Select the pigsty for brooding of 1 30 ~ 60 age in days, therefrom select the piglet of 204 clinical symptoms performance health as experimental animal.
1.1.2 test material
Chinese medicine formula: embodiment 1 prescription.
Contrast medicament: tylosin+herd happy health (yellow amine pregnancy+Sulfamonomethoxine (TMP)), wherein tylosin is produced by Huangyan, Zhejiang animal pharmaceutical factory, herds happy health (Compound Sulfachorpyrdazine Sodium Powder+trimethoprim (TMP)): Chinanimal Nanjing Veterinary Drugs Co., Ltd..
1.2 method
1.2.1 EXPERIMENTAL DESIGN
From the piglet of 204 clinical symptoms performance health, principle that is close by body weight, male and female half and half is divided into 4 process at random, each process 3 repetition, each repetition 17 pigs.Wherein daily ration matched group based on A group, daily ration+western medicine group based on B group, the compound Chinese herb prescription of daily ration+0.3 % percentage by weight based on C group, the compound Chinese herb prescription of daily ration+0.6 % percentage by weight based on D group.
Feeding and management preliminary trial period (feeding and management condition is identical with experimental period) 5d, during this period, carry out conventional anthelmintic and injection epidemic prevention, overbit is beaten to test pig, enter after preliminary trial period terminates and just try the phase, when piglet enters 15 kg body weight, carry out pig lung plague vaccine immunity.Adopt group feeding method to feed, every day, feeding 3 times, freely drank water.Other management is carried out according to a conventional method.
1.2.2 growth performance measures
Chinese herbal medicine add prescription feed before (November 9) title quality is carried out to all test piglets, record the feed consumption rate of test pig every day, feed after 30d continuously, at the end of (December 9 days) again claim its quality by head, calculate piglet average weight gain, Average weight increasing a day (ADG), feed intake (ADFI) and feed-weight ratio (F/G).
1.2.4 date processing
All test datas represent with average, variance analysis is carried out by the One-Way ANOVA program in SPSS 17.0 software, multiple comparisons is carried out, using P<0.05 (significant difference) as significance of difference criterion by DuncanShi method.
results and analysis
2.1 Chinese medicine formulas are on the impact of nursery pig growth performance
Chinese medicine formula test group to the impact effect of piglet growth performance in table 1.Table 1 is visible, adds the growth performance that Chinese medicine formula improves piglet in daily ration.After using Chinese medicine formula 30d, 0.6% Chinese medicine formula, 0.3% Chinese medicine formula test group average daily gain are respectively 329.10g, 263.49g, the average daily gain of blank group is 182.61g, Chinese herbal medicine test group is than many weightening finishes every day of blank group 146.49g, 80.88g, improve 80.22%, 44.29% respectively, difference extremely significantly (P < 0.01); The average daily feed intake of Chinese herbal medicine test group is respectively 572.33g, 521.24g, and the average daily feed intake of blank group is 373.17g, obvious difference (P < 0.05).
In addition, after adding Chinese medicine formula, also improve the conversion ratio of feedstuff, the feed cost of every kilogram of weightening finish can be reduced.Chinese herbal medicine test group feed-weight ratio is 1.72:1,1.74:1, and matched group is 2.08: 1, and test group reduces 0.36,0.24 than blank group, significantly improves efficiency of feed utilization (P < 0.05).
Table 1 Chinese medicine formula is on the impact of pig growth performance
Note: with column data shoulder mark same letter or non-note word matrix differential different remarkable, the different letter representation significant difference of shoulder mark.
2.2 impacts on piglet Average weight increasing a day
as can be seen from Figure 1, in Piglet Diets, add Chinese medicine formula, the average daily feed intake between 2 variable concentrations processed group, average daily gain, feed-weight ratio difference are not remarkable.But numerically, the average daily feed intake of Xin Pule interpolation group is higher than matched group, and feed-weight ratio comparatively matched group is low, such per gain weight, required cost reduces.
2.3 impacts on the average daily feed intake of piglet
Feedstuff adds the impact of Chinese medicine formula on the average daily feed intake of piglet and sees Fig. 2.Fig. 2 show, in the early stage diet of piglet, add 0.6% Chinese medicine formula, average daily feed intake higher than 0.3% Chinese medicine formula, be significantly higher than Western medicine contrast and blank.Feeding 20 days afterwards average daily feed intake, numerically on the contrary slightly lower than 0.3% Chinese medicine formula group, but does not reach significance impact, but still higher than Western medicine contrast and blank.
2.4 impacts on piglet key health situation
As shown in Figure 3, add Chinese medicine formula and not only the average daily feed intake tool of piglet is had a certain impact, also promote the robust growth of piglet.Wherein the survival number of 0.6% Chinese herbal medicine group, 0.3% Chinese herbal medicine group, strong pig number, strong pig rate are all significantly better than non-administered group, and compared with classical Western medicine, 0.6% Chinese herbal medicine group, 0.3% Chinese herbal medicine group are also significantly higher than classical Western medicine group.And the strong pig number of classical Western medicine group, strong pig rate are on the contrary lower than non-administered group, but do not reach significant difference.
In addition, susceptible piglet clinical symptoms obviously alleviates or disappears, and mortality rate reduces greatly.Wherein 0.6% Chinese herbal medicine group, 0.3% Chinese herbal medicine group piglet death toll are respectively 2,5, and Western medicine contrast with not administration group be respectively reach 6 with 15.
2.5 impacts on piglet growth situation
As shown in Figure 4, add the upgrowth situation of Chinese medicine formula to piglet and have obvious facilitation, growth evenly.The piglet number (being 21) being in 16-25kg is significantly higher than Western medicine contrast and blank group (being 13).Be less than 16kg all less with the piglet being greater than 25kg, only have 4-6 head, and blank group, western medicine group reach 7,11 respectively.
Claims (3)
1. treat a compound Chinese medicinal preparation for pig blue-ear disease, it is characterized in that, crude drug is made up of the component of following parts by weight:
Herba Schizonepetae 4 ~ 8 parts, Radix Saposhnikoviae 8 ~ 12 parts, Radix Bupleuri 4 ~ 8 parts, Radix Peucedani 4 ~ 8 parts, Rhizoma Et Radix Notopterygii 4 ~ 8 parts, Radix Angelicae Pubescentis 4 ~ 8 parts, Leptoradix Ginseng 4 ~ 8 parts, Fructus Arctii 4 ~ 8 parts, Fructus Aurantii 4 ~ 8 parts, 4 ~ 8 parts, Poria, Radix Platycodonis 4 ~ 8 parts, Rhizoma Chuanxiong 4 ~ 8 parts, 4 ~ 8 parts, Radix Glycyrrhizae, Herba Menthae 4 ~ 8 parts, Radix Scutellariae 4 ~ 8 parts, Radix Trichosanthis 4 ~ 8 parts.
2. the compound Chinese medicinal preparation for the treatment of pig blue-ear disease according to claim 1, is characterized in that, crude drug is made up of the component of following parts by weight:
Herba Schizonepetae 6 parts, Radix Saposhnikoviae 10 parts, Radix Bupleuri 6 parts, Radix Peucedani 6 parts, Rhizoma Et Radix Notopterygii 6 parts, Radix Angelicae Pubescentis 6 parts, Leptoradix Ginseng 6 parts, Fructus Arctii 6 parts, Fructus Aurantii 6 parts, 6 parts, Poria, Radix Platycodonis 6 parts, Rhizoma Chuanxiong 6 parts, 6 parts, Radix Glycyrrhizae, Herba Menthae 6 parts, Radix Scutellariae 6 parts, Radix Trichosanthis 6 parts.
3. the compound Chinese medicinal preparation for the treatment of pig blue-ear disease according to claim 1 and 2, is characterized in that: the dosage form of described compound Chinese medicinal preparation is powder.
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| CN111905016A (en) * | 2020-09-16 | 2020-11-10 | 北京农学院 | Traditional Chinese medicine prescription for treating porcine reproductive and respiratory syndrome and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111905016A (en) * | 2020-09-16 | 2020-11-10 | 北京农学院 | Traditional Chinese medicine prescription for treating porcine reproductive and respiratory syndrome and preparation method thereof |
| CN111905016B (en) * | 2020-09-16 | 2021-12-03 | 北京农学院 | Traditional Chinese medicine prescription for treating porcine reproductive and respiratory syndrome and preparation method thereof |
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