CN104473169A - Fish glue containing healthcare product and preparation method thereof - Google Patents
Fish glue containing healthcare product and preparation method thereof Download PDFInfo
- Publication number
- CN104473169A CN104473169A CN201410829738.9A CN201410829738A CN104473169A CN 104473169 A CN104473169 A CN 104473169A CN 201410829738 A CN201410829738 A CN 201410829738A CN 104473169 A CN104473169 A CN 104473169A
- Authority
- CN
- China
- Prior art keywords
- fish glue
- preparation
- health products
- ginseng
- extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000004833 fish glue Substances 0.000 title claims abstract description 71
- 238000002360 preparation method Methods 0.000 title claims abstract description 24
- 238000004519 manufacturing process Methods 0.000 title description 3
- 235000008434 ginseng Nutrition 0.000 claims abstract description 28
- 241000208340 Araliaceae Species 0.000 claims abstract description 27
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 27
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 27
- 239000011435 rock Substances 0.000 claims abstract description 26
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 16
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 16
- 238000005336 cracking Methods 0.000 claims abstract description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000008213 purified water Substances 0.000 claims abstract description 10
- 238000010438 heat treatment Methods 0.000 claims abstract description 9
- 235000016709 nutrition Nutrition 0.000 claims abstract description 8
- 238000001914 filtration Methods 0.000 claims abstract description 7
- 239000012528 membrane Substances 0.000 claims abstract description 7
- 229920002521 macromolecule Polymers 0.000 claims abstract description 5
- 238000001223 reverse osmosis Methods 0.000 claims abstract description 5
- 239000000047 product Substances 0.000 claims description 43
- 230000036541 health Effects 0.000 claims description 38
- 241000222336 Ganoderma Species 0.000 claims description 21
- 239000000284 extract Substances 0.000 claims description 13
- 239000007788 liquid Substances 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 10
- 239000012141 concentrate Substances 0.000 claims description 6
- 239000003292 glue Substances 0.000 claims description 4
- 238000002372 labelling Methods 0.000 claims description 4
- 239000000919 ceramic Substances 0.000 claims description 2
- 238000000605 extraction Methods 0.000 claims description 2
- 239000000706 filtrate Substances 0.000 claims description 2
- 239000004615 ingredient Substances 0.000 claims description 2
- 235000020710 ginseng extract Nutrition 0.000 claims 2
- 238000000197 pyrolysis Methods 0.000 claims 2
- 238000010521 absorption reaction Methods 0.000 abstract description 6
- 239000004480 active ingredient Substances 0.000 abstract description 6
- 239000003814 drug Substances 0.000 abstract description 4
- 230000035764 nutrition Effects 0.000 abstract description 4
- 238000002156 mixing Methods 0.000 abstract description 3
- 240000008397 Ganoderma lucidum Species 0.000 abstract 3
- 235000001637 Ganoderma lucidum Nutrition 0.000 abstract 3
- 240000004371 Panax ginseng Species 0.000 abstract 1
- 235000002789 Panax ginseng Nutrition 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 description 15
- 241000699666 Mus <mouse, genus> Species 0.000 description 13
- -1 2000 parts Substances 0.000 description 11
- 238000012360 testing method Methods 0.000 description 11
- 238000002474 experimental method Methods 0.000 description 8
- 102000008186 Collagen Human genes 0.000 description 5
- 108010035532 Collagen Proteins 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 5
- 241000699670 Mus sp. Species 0.000 description 5
- 229920001436 collagen Polymers 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 239000002994 raw material Substances 0.000 description 5
- 230000008901 benefit Effects 0.000 description 4
- 239000013642 negative control Substances 0.000 description 4
- 241000607142 Salmonella Species 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000001185 bone marrow Anatomy 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 230000036039 immunity Effects 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 231100000027 toxicology Toxicity 0.000 description 3
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 238000012449 Kunming mouse Methods 0.000 description 2
- 210000004712 air sac Anatomy 0.000 description 2
- 230000036528 appetite Effects 0.000 description 2
- 235000019789 appetite Nutrition 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000000084 colloidal system Substances 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000003304 gavage Methods 0.000 description 2
- 229940089161 ginsenoside Drugs 0.000 description 2
- 229930182494 ginsenoside Natural products 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 235000004213 low-fat Nutrition 0.000 description 2
- 230000000242 pagocytic effect Effects 0.000 description 2
- 239000013641 positive control Substances 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 230000002110 toxicologic effect Effects 0.000 description 2
- 241000251468 Actinopterygii Species 0.000 description 1
- 241000251730 Chondrichthyes Species 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 244000000626 Daucus carota Species 0.000 description 1
- 206010058314 Dysplasia Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 229920002527 Glycogen Polymers 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 231100000460 acute oral toxicity Toxicity 0.000 description 1
- 238000011047 acute toxicity test Methods 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 235000005770 birds nest Nutrition 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 210000003792 cranial nerve Anatomy 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 230000007674 genetic toxicity Effects 0.000 description 1
- 231100000025 genetic toxicology Toxicity 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 229940096919 glycogen Drugs 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 235000001497 healthy food Nutrition 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 239000012669 liquid formulation Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000001853 liver microsome Anatomy 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 231100000682 maximum tolerated dose Toxicity 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229940099908 multivitamin and calcium Drugs 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000002417 nutraceutical Substances 0.000 description 1
- 235000021436 nutraceutical agent Nutrition 0.000 description 1
- 235000008935 nutritious Nutrition 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 150000003071 polychlorinated biphenyls Chemical class 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 231100000527 sperm abnormality Toxicity 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 235000019605 sweet taste sensations Nutrition 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 235000005765 wild carrot Nutrition 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a fish glue containing healthcare product and a preparation method thereof. The preparation method comprises the following steps: taking panax ginseng and ganoderma lucidum, respectively adding purified water to the ginseng and ganodermalucidum, heating, boiling, extracting, filtering, separating by utilizing a macromolecule reverse osmosis membrane, eluting, decompressing and condensing to obtain ginseng and ganoderma lucidum extracting solutions; adding purified water with the weight which is 2 times of that of the fish glue, digesting the fish glue for 30 min at 70-80 DEG C, adding the purified water, cracking protein for 30 min at 90-100 DEG C, and cracking the protein for 30 min at 100-110 DEG C to obtain cracking extracting solution and residues; cracking the protein in the residues for 30 min at 90-100 DEG C, and cracking the protein for 30 min at 100-110 DEG C to obtain a cracking solution; combining the two cracking solutions, decompressing, concentrating, centrifuging a concentrated solution, and filtering the centrifuged solution to obtain a fish glue extracting solution; mixing all of the solutions with a rock sugar solution. According to the fish glue containing healthcare product and a preparation method thereof, active ingredients in medicines are fully extracted so as to facilitate absorption of human body and improve the nutrition absorption rate.
Description
Technical field
The present invention relates to field of health care products, in particular to a kind of health products containing fish glue and preparation method thereof.
Background technology
The dried product of fish glue and air bladder (assisted respiartion organ), rich colloid, therefore named fish glue, also claims fish maw, flower glue.Fish glue and bird's nest, shark's fin are equally celebrated for their achievements, are one of " eight delicacies ", have the reputation of " ocean ginseng ".Its main component is the various trace elements such as senior collagen, multivitamin and calcium, zinc, iron, selenium.Its protein content is up to 84.2%, and fat is only 0.2%, is desirable high protein and low fat food.Be that human body supplements, the raw material of synthetic protein, and be easy to absorb and utilize.
Fish glue can strengthen the digestion and absorption function of stomach and intestine, improves appetite, is conducive to the illnesss such as control poor appetite, indigestion, constipation; Toughness and the elastic force of musculature can be strengthened, strengthen muscle power, dispelling fatigue; Can cranial nerve function be strengthened, enhancing development, improve thinking and intelligence, maintain body of gland normal secretions; Slow in reacting, dysplasia of children, puerpera's galactosis deficiency, old forgetful insomnia etc. can be prevented and treated.Because fish glue contains a large amount of glue juice, have again invigorate blood circulation, enrich blood, stop blooding, effects such as clearing damp of keeping out the cold, so can immunity be improved, for having a delicate constitution, Kidney-Yin loss, psychentonia personage, more suitable as nourishing.In addition, the optimal selection of fish glue or women's replenishing collagen.Protein in human body skin has 70% to be collagen, and the network structure formed supports skin, and make skin seem smooth full, softness is high resilience again.With advancing age, the speed that collagen in skin histology runs off has exceeded the speed generated gradually, so skin follows the string thinning aging, occurs lax, wrinkle, the phenomenon such as dry and astringent, so in good time replenishing collagen, skin can be made to renew one's youth vigor.
At present, the health products containing fish glue are varied, mainly contain two classes: a kind of is the health products only having fish glue single component, a kind of combined health care products being fish glue and other medicinal material and mixing.Wherein, combined health care products is nutritious comprehensively more welcome with it.
The existing combined health care products containing fish glue mainly adopts following two kinds of methods to make: one, obtains pulvis by after all the components abrasive dust after mixing; Two, all the components is dissolved in a certain solvent and forms oral liquid.All there is following problem in these two kinds of methods: fish glue does not fully discharge with the active ingredient in other medicinal material, causes taking rear nutrition absorption rate low.
In view of this, special proposition the present invention.
Summary of the invention
The first object of the present invention is to provide a kind of preparation method of the health products containing fish glue, and the active component in fish glue and ginseng, glossy ganoderma can fully extract by described preparation method, is beneficial to human body and absorbs fast, improve nutrition absorption rate.
The second object of the present invention is to provide a kind of described health products containing fish glue, and these health products have the purposes of enhanced machine body immunity function and alleviating physical fatigue, and which are added rock sugar, and sweet taste improves, more welcome.
In order to realize above-mentioned purpose of the present invention, spy by the following technical solutions:
Containing a preparation method for the health products of fish glue, be made up of following steps:
Steps A: by weight, gets 1500-2500 part ginseng, adds the purified water of 12 times amount, by heating, boil extraction 2 times, to refilter, merging filtrate, then with macromolecule reverse osmosis membrane carry out being separated, wash-out, being evaporated to relative density is again 1.05-1.10, obtains Ginseng extract;
Step B: get 2500-3500 part glossy ganoderma, the process identical with the ginseng in described steps A is carried out to it, obtains lucidum extracting liquid;
Step C: get 2500-3500 part fish glue, after adding the purified water of 2 times amount, changes glue 30min at 70-80 DEG C, add to the purified water of 6 times amount afterwards, crack protein 30min at 90-100 DEG C, afterwards crack protein 30min at 100-110 DEG C, obtain a cracking extract and residue;
Step D: by described residue crack protein 30min at 90-100 DEG C, crack protein 30min at 100-110 DEG C, obtains second pyrolysis extract afterwards;
Step e: merge a described cracking extract and described second pyrolysis extract, then reduced pressure concentration, obtain concentrate;
Step F: described concentrate is centrifugal under 12000rpm, adopt ceramic membrane filter, the effective protein ingredient of Small molecular that molecular cut off is less than 6000, obtains fish glue extract;
Step G: get 1500-2500 part rock sugar, add the water of 4 times amount wherein, rock sugar is dissolved, obtain rock sugar solution;
Step H: described Ginseng extract, described lucidum extracting liquid, described fish glue extract and described rock sugar solution are mixed, filters, obtain product.
In above-mentioned preparation method, by heating, filter and macromolecule reverse osmosis membrane separation, wash-out mode the active component in ginseng and glossy ganoderma is fully extracted out; Also by the mode of crack protein, the active component in fish glue is fully extracted out, thus obtains the high health products of a kind of nutrition absorption rate.Wherein, when preparing fish glue extract, first at 90-100 DEG C crack protein, at 100-110 DEG C, fully by extracts active ingredients out, and protein ingredient could be cracked into the absorbable albumen of human body twice to fish glue cracking again.
Further, in described steps A and B, with macromolecule reverse osmosis membrane carry out being separated, wash-out obtains the nutritional labeling that molecular weight is less than 4000.
Active ingredient in the following ginseng of this molecular weight and glossy ganoderma has all been collected.
Further, in described steps A and B, the time that each heating is extracted is 1.5h.
Found by research, at this time point, recovery rate is to peak.
Further, in described steps A and B, also comprise after concentration: filter with 200 object sieves.Invalid components in solution can be crossed by the filtration of this particle diameter and filter.
Further, in described step G, also comprise after rock sugar fusing: filter with 120 object sieves.Can by the contaminant filter removing in rock sugar by the filtration of this particle diameter.
Further, in described step H, be filtered into: filter with 180 object sieves.Invalid components in solution can be crossed by the filtration of this particle diameter and filter.
Further, ginseng 2000 parts is got in described steps A; Glossy ganoderma 3000 parts is got in described step B; 3000 parts, fish glue is got in described step C; 2000 parts, rock sugar is got in described step H.
Further, in described steps A and B, the condition of described reduced pressure concentration is: 0.07MPa, 75-85 DEG C.Adopt this condition thickening efficiency high, and can ensure that the active ingredient of stripping is not destroyed.
Further, in described step G, the method that rock sugar is dissolved is: heating.To accelerate rock sugar fusing.
Containing health products for fish glue, it adopts arbitrary preparation method above to obtain.
Compared with prior art, beneficial effect of the present invention is:
(1) active ingredient in fish glue, ginseng and glossy ganoderma is fully extracted.
(2) nutrition absorption rate is high.
(3) mouthfeel of health products is good.
(4) the enhanced machine body immunity function of health products and the effect of alleviating physical fatigue more obvious.
Detailed description of the invention
Below in conjunction with embodiment, embodiment of the present invention are described in detail, but it will be understood to those of skill in the art that the following example only for illustration of the present invention, and should not be considered as limiting the scope of the invention.Unreceipted actual conditions person in embodiment, the condition of conveniently conditioned disjunction manufacturer suggestion is carried out.Agents useful for same or the unreceipted production firm person of instrument, be and can buy by commercially available the conventional products obtained.
Embodiment 1
Containing health products for fish glue, consist of the following composition: ginseng 2000 parts, glossy ganoderma 3000 parts, 3000 parts, fish glue, 2000 parts, rock sugar.
Embodiment 2
Containing health products for fish glue, consist of the following composition: ginseng 1500 parts, glossy ganoderma 2500 parts, 2500 parts, fish glue, 1500 parts, rock sugar.
Embodiment 3
Containing health products for fish glue, consist of the following composition: ginseng 1600 parts, glossy ganoderma 2600 parts, 2600 parts, fish glue, 1600 parts, rock sugar.
Embodiment 4
Containing health products for fish glue, consist of the following composition: ginseng 1700 parts, glossy ganoderma 2700 parts, 2700 parts, fish glue, 1700 parts, rock sugar.
Embodiment 5
Containing health products for fish glue, consist of the following composition: ginseng 1800 parts, glossy ganoderma 2800 parts, 2800 parts, fish glue, 1800 parts, rock sugar.
Embodiment 6
Containing health products for fish glue, consist of the following composition: ginseng 1900 parts, glossy ganoderma 2900 parts, 2900 parts, fish glue, 1900 parts, rock sugar.
Embodiment 7
Containing health products for fish glue, consist of the following composition: ginseng 2100 parts, glossy ganoderma 3100 parts, 3100 parts, fish glue, 2100 parts, rock sugar.
Embodiment 8
Containing health products for fish glue, consist of the following composition: ginseng 2200 parts, glossy ganoderma 3200 parts, 3200 parts, fish glue, 2200 parts, rock sugar.
Embodiment 9
Containing health products for fish glue, consist of the following composition: ginseng 2300 parts, glossy ganoderma 3300 parts, 3300 parts, fish glue, 2300 parts, rock sugar.
Embodiment 10
Containing health products for fish glue, consist of the following composition: ginseng 2400 parts, glossy ganoderma 3400 parts, 3400 parts, fish glue, 2400 parts, rock sugar.
Embodiment 11
Containing health products for fish glue, consist of the following composition: ginseng 2500 parts, glossy ganoderma 3500 parts, 3500 parts, fish glue, 2500 parts, rock sugar.
Above embodiment 1-11 can adopt the method for embodiment 12 or 13 to obtain.
Embodiment 12
Containing a preparation method for the health products of fish glue, be made up of following steps:
Steps A: get ginseng, adds the purified water of 12 times amount, by heating extraction 2 times, refilters, merging filtrate, then with macromolecule reverse osmosis membrane carry out being separated, wash-out, then to be evaporated to relative density be 1.05-1.10, obtains Ginseng extract;
Step B: get glossy ganoderma, carries out the process identical with the ginseng in described steps A to it, obtains lucidum extracting liquid;
Step C: get fish glue, after adding the purified water of 2 times amount, glue 30min is changed at 70-80 DEG C, add to the purified water (referring on the basis of the water yield added in first time) of 6 times amount afterwards, crack protein 30min at 90-100 DEG C, crack protein 30min at 100-110 DEG C afterwards, obtains a cracking extract and residue;
Step D: by described residue crack protein 30min at 90-100 DEG C, crack protein 30min at 100-110 DEG C, obtains second pyrolysis extract afterwards;
Step e: merge a described cracking extract and described second pyrolysis extract, then reduced pressure concentration, obtain concentrate;
Step F: described concentrate is centrifugal under 12000rpm, adopt ceramic membrane filter, the effective protein ingredient of Small molecular that molecular cut off is less than 6000, obtains fish glue extract;
Step G: get rock sugar, adds the water of 4 times amount wherein, and rock sugar is dissolved, and obtains rock sugar solution;
Step H: described Ginseng extract, described lucidum extracting liquid, described fish glue extract and described rock sugar solution are mixed, filters, obtain product.
Embodiment 13
Get ginseng tablet, Investigation of Lingzhi Tablets, after correct amount, add the purified water of 12 times amount, heating, boils, extracts 2 times, 1.5h/ secondary, plate-frame filtering (200 order), merging filtrate, with macromolecule reverse osmosis membrane carry out being separated, wash-out, obtain effective active compositions such as being less than the GL-B of below 4000 dalton and ginsenoside, reduced pressure concentration (0.07MPa, 75-85 DEG C), to relative density 1.05-1.10 (60 DEG C), obtains concentrate, for subsequent use.
The preparation of described fish glue extract: get fish glue, after correct amount, add the purified water of 2 times amount at 70-80 DEG C of carrying out glue 30min, add to the purified water of 6 times amount afterwards, adopt secondary cycle mode cracking 2 times, i.e. crack protein 30min, electrical heating 100-110 DEG C crack protein 30min at 90-100 DEG C, 90-100 DEG C of cracking 30min, and electrical heating 100-110 DEG C of cracking 30min.Merge cracking extract, reduced pressure concentration.Concentrate is centrifugal under 12000rpm, adopts ceramic membrane filter, the effective protein ingredient of Small molecular that molecular cut off is less than 6000, stored refrigerated, prepares the fish glue extract without precipitation, for subsequent use.
By ginseng and lucid ganoderma extract, fish glue extract, rock sugar solution three kinds of solution, mix, stir, add purified water to enough by amount of calculation, place, filter (180 order), obtain preparation liquid, namely obtain oral liquid through canned, sterilizing.
Experimental example 1
According to the progresses and methods that security and the functional trial of " health food inspection and assessment technical specification " (version in 2003) are evaluated, the oral liquid mainly prepared the present invention has carried out significant composition, hygiene, stability, toxicology, function assessment (develop immunitypty function, alleviating physical fatigue function).Experimental technique is as follows, and experimental result refers to table.
Note: oral liquid of the present invention adopts the formula of embodiment 1 and the method for embodiment 13 to obtain.
1, toxicological experiment
1.1 acute oral toxicity tests:
Animal used as test: female, the male mouse of Kunming kind (SPF level).
Experimental technique: adopt maximum tolerated dose method, weighed by Kunming mouse, and random packet, gastric infusion, observes and records animal state.
1.2 3 genetic toxicity tests
1.2.1Ames test:
Experimental strain: salmonella typhimurium histidine deficient TA97 TA98 TA100 TA102.
Experimental technique: adopt the rat liver microsomes enzyme (S-9) of Polychlorinated biphenyls PCB induction as In vitro metabolism active system.Be divided into 5 dosage, if certainly beam back change, solvent control and Positive mutants agent contrast.
1.2.2 mice bone marrow micronucleus:
Animal used as test: adopt Kunming mouse.
Experimental technique: random point 5 groups, male and female half and half.Take endoxan as positive control, distilled water is negative control, if senior middle school's low dose group.
1.2.3 mouse inbred strain:
Animal used as test: male mice in kunming;
Experimental technique and step: be divided into 5 groups at random, take endoxan as positive control, distilled water is negative control, if senior middle school's low dose group.
1.330 it feeding trial
Animal used as test: SD rat, male and female half and half.
Experimental technique and step: control group, senior middle school's low dose group, by 6.25 times of oral liquid gavages that the present invention prepares.
Overall toxicological experiment result display, the maximal tolerance dose of 6.25 times of these concentrates to experimental animal is greater than 21.07g/kgbw, belongs to nontoxic level.Salmonella reversion test, mice bone marrow micronucleus, mouse inbred strain result are feminine gender.Feeding trial result display in 30 days has no obvious toxic-side effects to rat.
Above-mentioned experimental result is as following table 1-6
Table 1 sample acute toxicity test in mice result
Table 2 sample Salmonella reversion test result (for the second time)
Table 3 sample Salmonella reversion test result (for the second time)-continuous
Table 4 sample is on the impact of Micronuclei In The Mouse Bone Marrow incidence
Note: * compares with negative control group, P<0.01.
Table 5 sample is on the impact of Sperm Abnormalities of Mice
Note: * compares with negative control group, P<0.01.
Table 6 sample 30 days feeding trial biochemical investigation in latter stage results
2 function assessment tests
2.1 develop immunitypty functions
Per os gavage gives this concentrate 30 days of the high, normal, basic dosage of mouse, compare with control group, middle and high dosage group can significantly improve mouse delayed allergy ability, antibody-producting cell number, NK cytoactive, high dose consummately can improve mouse carbonic clearance phagocytic index, HD50 value (P<0.05), and the ability of each dosage to Mouse Weight growth, thymus gland/body weight ratio, spleen/body weight ratio, lymphocyte transformation ability and macrophage phagocytic chicken red blood cell does not all make significant difference (P>0.05).Result shows, oral liquid of the present invention has develop immunitypty function.
2.2 alleviating physical fatigue function zooperies
Per os gives the oral liquid 30 days of the high, normal, basic dosage of mouse, high dose can obviously extend mouse heavy burden playtime, increase Mouse Liver glycogen storage level, reduce mouse movement after serum urea level, have conspicuousness (P<0.05) with control group comparing difference.Each dosage has no obvious impact (P>0.05) to Mouse Blood lactic acid TG-AUC.Result shows, oral liquid of the present invention has alleviating physical fatigue function.
In summary, compared with prior art, the beneficial effect of a kind of composition containing fish glue provided by the invention is as follows:
1) there is the ginseng of develop immunitypty and alleviating physical fatigue, glossy ganoderma for primary raw material through traditional Chinese medicine and modern pharmacology research theoretical proof, can blood-enrich, kidney tonifying benefit lung, integrally-regulated, strengthening vital QI to eliminate pathogenic factors, reach the health-care efficacy of develop immunitypty and alleviating physical fatigue.And persistent, raw material sources are extensive, the material benefit of reliable in quality, price.
2) fish glue raw material used, there is effect of liver-kidney tonifying, nourishing blood and hemoslasis, eliminating stasis to subdue swelling, containing abundant nutritional labeling, air bladder has colloid, it is the important aquatic food resource being rich in high protein, low fat and mineral matter, have the reputation of " ocean ginseng ", there is tonic effect and medical value.
3) be raw materials usedly safe healthy food material, auxiliary material used is few, without incompatibility, the consumption of formula Raw is all within the scope of safety using amount, and production technology meets food hygiene related request, therefore this product edible safety, without any side effects, can eat for a long time.
4) select ginseng, glossy ganoderma is conventional Chinese medicine, the ginsenoside in ginseng, the polysaccharide component etc. in glossy ganoderma all have good water-soluble.Fish glue is conventional nutraceutical, and among the people taking mainly with stewing greatly is main.Therefore, according to being conducive to the characteristics and advantages keeping and develop Chinese medicine traditional decoction, this product selects oral liquid formulation, has and is convenient to take, absorb soon, and technique is simple, sterilization preparation is easy to reach sanitary standard, steady quality, advantage with low cost etc., be applicable to vastly need crowd.
5) adopt unique extraction conditions, both improve the recovery rate of active ingredient, and which in turn improved the molecular weight of nutritional labeling, and made it more easily absorb.
Although illustrate and describe the present invention with specific embodiment, however it will be appreciated that can to make when not deviating from the spirit and scope of the present invention many other change and amendment.Therefore, this means to comprise all such changes and modifications belonged in the scope of the invention in the following claims.
Claims (10)
1., containing a preparation method for the health products of fish glue, it is characterized in that, be made up of following steps:
Steps A: by weight, gets 1500-2500 part ginseng, adds the purified water of 12 times amount, by heating extraction 2 times, to refilter, merging filtrate, then with macromolecule reverse osmosis membrane carry out being separated, wash-out, being evaporated to relative density is again 1.05-1.10, obtains Ginseng extract;
Step B: get 2500-3500 part glossy ganoderma, the process identical with the ginseng in described steps A is carried out to it, obtains lucidum extracting liquid;
Step C: get 2500-3500 part fish glue, after adding the purified water of 2 times amount, changes glue 30min at 70-80 DEG C, add to the purified water of 6 times amount afterwards, crack protein 30min at 90-100 DEG C, afterwards crack protein 30min at 100-110 DEG C, obtain a cracking extract and residue;
Step D: by described residue crack protein 30min at 90-100 DEG C, crack protein 30min at 100-110 DEG C, obtains second pyrolysis extract afterwards;
Step e: merge a described cracking extract and described second pyrolysis extract, then reduced pressure concentration, obtain concentrate;
Step F: described concentrate is centrifugal under 12000rpm, adopt ceramic membrane filter, the effective protein ingredient of Small molecular that molecular cut off is less than 6000, obtains fish glue extract;
Step G: get 1500-2500 part rock sugar, add the water of 4 times amount wherein, rock sugar is dissolved, obtain rock sugar solution;
Step H: described Ginseng extract, described lucidum extracting liquid, described fish glue extract and described rock sugar solution are mixed, filters, obtain product.
2. the preparation method of the health products containing fish glue according to claim 1, is characterized in that, in described steps A and B, with macromolecule reverse osmosis membrane carry out being separated, wash-out obtains the nutritional labeling that molecular weight is less than 4000.
3. the preparation method of the health products containing fish glue according to claim 1, is characterized in that, in described steps A and B, the time that each heating is extracted is 1.5h.
4. the preparation method of the health products containing fish glue according to claim 1, is characterized in that, in described steps A and B, also comprises after concentration: with 200 object sieves filtrations.
5. the preparation method of the health products containing fish glue according to claim 1, is characterized in that, in described step G, also comprises: filter with 120 object sieves after rock sugar fusing.
6. the preparation method of the health products containing fish glue according to claim 1, is characterized in that, in described step H, be filtered into: filter with 180 object sieves.
7. its preparation method of the health products containing fish glue according to claim 1, is characterized in that, get ginseng 2000 parts in described steps A; Glossy ganoderma 3000 parts is got in described step B; 3000 parts, fish glue is got in described step C; 2000 parts, rock sugar is got in described step H.
8. the preparation method of the health products containing fish glue according to claim 1, is characterized in that, in described steps A and B, the condition of described reduced pressure concentration is: 0.07MPa, 75-85 DEG C.
9. the preparation method of the health products containing fish glue according to claim 1, it is characterized in that, in described step G, the method that rock sugar is dissolved is: heating.
10. containing health products for fish glue, it is characterized in that, adopt the preparation method of the health products containing fish glue described in any one of claim 1-9 to make.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410829738.9A CN104473169B (en) | 2014-12-25 | 2014-12-25 | A kind of health product containing fish glue and preparation method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410829738.9A CN104473169B (en) | 2014-12-25 | 2014-12-25 | A kind of health product containing fish glue and preparation method thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104473169A true CN104473169A (en) | 2015-04-01 |
CN104473169B CN104473169B (en) | 2016-08-31 |
Family
ID=52747890
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410829738.9A Active CN104473169B (en) | 2014-12-25 | 2014-12-25 | A kind of health product containing fish glue and preparation method thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN104473169B (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107259561A (en) * | 2017-05-12 | 2017-10-20 | 广东利泰大健康产业股份有限公司 | Flower of Panax ginseng glue drink and preparation method thereof |
CN107397208A (en) * | 2016-07-20 | 2017-11-28 | 吴登成 | Using fish glue as functional food of principal component and application thereof |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109045101A (en) * | 2018-09-26 | 2018-12-21 | 北京维特百草健康科技有限公司 | Chinese medicine composition and its application containing Chinese medical extract |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1557207A (en) * | 2004-01-21 | 2004-12-29 | 雨田集团有限公司 | Swimming bladder glue product and its making process |
CN1919077A (en) * | 2006-09-15 | 2007-02-28 | 孙庆海 | Fish maw glue powder and its processing method |
CN101647562A (en) * | 2009-07-23 | 2010-02-17 | 杭州六易科技有限公司 | Preparation method of lady beauty and healthcare beverage |
CN101999582A (en) * | 2010-12-25 | 2011-04-06 | 河南科技大学 | Yam-swimming bladder collagen chewable tabs and preparation method thereof |
-
2014
- 2014-12-25 CN CN201410829738.9A patent/CN104473169B/en active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1557207A (en) * | 2004-01-21 | 2004-12-29 | 雨田集团有限公司 | Swimming bladder glue product and its making process |
CN1919077A (en) * | 2006-09-15 | 2007-02-28 | 孙庆海 | Fish maw glue powder and its processing method |
CN101647562A (en) * | 2009-07-23 | 2010-02-17 | 杭州六易科技有限公司 | Preparation method of lady beauty and healthcare beverage |
CN101999582A (en) * | 2010-12-25 | 2011-04-06 | 河南科技大学 | Yam-swimming bladder collagen chewable tabs and preparation method thereof |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107397208A (en) * | 2016-07-20 | 2017-11-28 | 吴登成 | Using fish glue as functional food of principal component and application thereof |
CN107259561A (en) * | 2017-05-12 | 2017-10-20 | 广东利泰大健康产业股份有限公司 | Flower of Panax ginseng glue drink and preparation method thereof |
Also Published As
Publication number | Publication date |
---|---|
CN104473169B (en) | 2016-08-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102415568B (en) | Health food for improving immunity and preparation method thereof | |
CN106173773A (en) | A kind of ferment probiotic bacteria solid beverage and preparation method thereof | |
CN104000233A (en) | Medicated diet sea cucumber can and processing method of medicated diet sea cucumber can | |
CN103653144A (en) | Healthcare drink capable of improving immunity and preparation method thereof | |
CN104473169B (en) | A kind of health product containing fish glue and preparation method thereof | |
CN111467468A (en) | Concentrated nutrient solution containing ginseng, cordyceps militaris, ginger and wolfberry fruit and preparation method thereof | |
CN103610076A (en) | Preparation method for sea cucumber capsule | |
CN107596112A (en) | A kind of kidney tonifying tea prescription and preparation method thereof | |
CN106472684A (en) | A kind of milk product | |
CN106472680A (en) | A kind of milk product | |
CN106472682A (en) | A kind of milk product | |
CN106035811A (en) | Detoxifying and body-building beverage | |
CN105901147A (en) | A healthcare type modified milk beverage comprising algae oil DHA and a preparing method thereof | |
CN106472681A (en) | A kind of milk product | |
CN103610068A (en) | Preparation method for blood-fat-reducing sea cucumber oral liquid | |
CN103610112A (en) | Immunity-enhancing sea cucumber oral liquid and application method thereof | |
CN103610069A (en) | Blood-sugar-reducing sea cucumber oral liquid | |
CN103355454A (en) | Food health-care tea electuary for preventing osteoporosis | |
CN103610116A (en) | Preparation method for sea cucumber nutritional capsule | |
CN106472683A (en) | A kind of milk product | |
CN105685229A (en) | Banana grape yogurt | |
CN105942069A (en) | Spirulina health-care beverage with immunity enhancing function and preparation method thereof | |
CN106174216A (en) | The neurasthenic ultra micro nutrition prescription of a kind of preventing and treating and preparation processing method | |
KR20130109677A (en) | Stichopus japonicus red essence and preparation method thereof | |
CN103610033A (en) | Immunity-enhancing sea cucumber oral liquid |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant |