CN104472495A - Insecticidal composition containing benzenecarbothioamide - Google Patents

Abstract

The invention discloses an insecticidal composition containing benzenecarbothioamide and relates to the technical field of pesticides. The insecticidal composition consists of an insecticidal active compound I and an insecticidal active component II, wherein the insecticidal active compound I is benzenecarbothioamide while the insecticidal active compound II is selected from one of an organophosphorus insecticide, a pyrethroid insecticide, a nereistoxin insecticide, an antibiotic insecticide and the like; the weight ratio of the insecticidal active compound I to the insecticidal active compound II is 1: 30 to 30: 1. The insecticidal composition has an obvious synergistic effect compared with that of a single dosage and can be used for effectively preventing and treating lepidoptera pests and homopteran pests, so that the dosage of the pesticide is reduced and the medicating cost is saved. Meanwhile, the insufficiency of insecticidal activity of benzenecarbothioamide and the tolerance of pests to benzenecarbothioamide are solved, so that the insecticidal activity is improved and the insecticidal spectrum is wide.

Description

Containing the Pesticidal combination of thiobenzamide

Technical field

The present invention relates to technical field of pesticide, especially a kind of Pesticidal combination containing thiobenzamide.

Background technology

Chinese invention patent " thiobenzamide compounds and application thereof ", publication number CN103109816A, the general structure 1 disclosing thiobenzamide compounds is:

Have the thiobenzamide compounds of above-mentioned general formula 1, not only have high activity to lepidoptera pest, and also have beyond thought high activity to sucking pest (as rice fulgorid), this compounds has well double controlling and acts on and comprehensive function.Thiobenzamide compounds enters in invertebral pest body, sulphur atom is oxidized to oxygen atom rapidly, become benzamide compound and play toxic action, but this process is carried out very slow in vertebrate higher mammal body, therefore sulphur atom replaces oxygen atom is conducive to reducing the impact of compound on people and animals and environment, thus safer environmental protection.

Applicant is chlorine according to the preferred R1 of general formula 1, and R2 is methyl, obtains insecticidal active compound I of the present invention with reference to method disclosed in Chinese patent CN103109816A.Although insecticidal active compound I is also the same with thiobenzamide compounds have outstanding insecticidal effect, it can not meet pest resistance and highly active requirement completely.So with other kind pesticide compositionals are the important means compensating its defect and increase the scope of application.Insecticidal active compound I, as at areal Long-Time Service, makes the raising of crop pests to its resistance namely develop immunity to drugs.Therefore in order to delay the service life of insecticidal active compound I, reducing the cost of novel pesticide exploitation, being badly in need of the Pesticidal combination that exploitation is composite with it.

Up to now, such Compound I is not also shown in the report with the patent of other pesticide compositionals.

Summary of the invention

The object of the invention is to: for above-mentioned Problems existing, there is provided containing sulfo-benzamides Pesticidal combination, itself and other insecticide is carried out composite, this Pesticidal combination has obvious synergistic effect relative to single dose, can effectively prevent and treat lepidoptera pest or homoptera pest, reduce the using dosage of agricultural chemicals, save drug cost, solve the deficiency of thiobenzamide class insecticidal activity and insect to its tolerance, improve insecticidal activity, insecticidal spectrum is more extensive simultaneously.

For realizing above-mentioned object, the technical scheme that the present invention takes:

The invention provides containing sulfo-benzamides Pesticidal combination, this Pesticidal combination is made up of insecticidal active compound I and insecticidal active compound II; Wherein, insecticidal active compound I is thiobenzamide, its chemistry bromo-N-of 3-[4-chloro-2-methyl-6-(methylamino thioformyl) benzene]-1-(3-chloropyridine-2-base)-1H-pyrazoles-5-formamide by name; Insecticidal active compound II is selected from any one of compound in following II.1-II.5;

II.1) organophosphorus insecticides;

II.2) pyrethroid insecticides;

II.3) sandworm toxin insecticide;

II.4) antibiotic insecticide;

II.5) other insecticides: be selected from the one in indoxacarb, capillary, ethiprole, Buprofezin, HEXAFLUMURON, diafenthiuron, metaflumizone;

When in Pesticidal combination of the present invention, reactive compound exists with specified weight ratio, syneryistic effect highly significant, preferably, the weight ratio of insecticidal active compound I and insecticidal active compound II is 1:30 ~ 30:1.

Further, the weight ratio of insecticidal active compound I and insecticidal active compound II is 1:10 ~ 10:1.

In the present invention, the structural formula of described thiobenzamide is as follows:

Insecticidal active compound II is known and disclosed pesticide activity component, the insecticidal effect that equal tool is good.Wherein, organophosphorus insecticides is selected from the one in chlopyrifos, phoxim, Profenofos, Hostathion, malathion, quinalphos, diazinon; Pyrethroid insecticides is selected from gamma cyhalothrin, Biphenthrin, decis, ether chrysanthemum ester, beta-cypermethrin, first cyanogen chrysanthemum fat, sumicidin a kind of; Sandworm toxin insecticide is selected from the one in cartap, dimehypo, Cupric sulfate; Antibiotic insecticide is selected from Affirm (Merck Co.), Avermectin, pleocidin, Ivermectin HCL a kind of.

The present invention also provides a kind of agricultural insecticide, comprises acceptable auxiliary material on the Pesticidal combination containing thiobenzamide provided by the invention and agricultural chemicals.Described Pesticidal combination accounts for described agricultural insecticide gross weight 1% ~ 80%.Further preferably, described Pesticidal combination accounts for 20% ~ 60% of described agricultural insecticide gross weight.

Above-mentioned auxiliary material is the mixture of a kind of and auxiliary agent in solid carrier or liquid-carrier.Any carrier and the auxiliary agent that are generally used for composition pesticide all can use.

According to different user demands, agricultural insecticide provided by the invention can be made into multiple formulation.Preferably, can be made in wetting powder, water dispersible granules, missible oil, aqueous emulsion, suspending agent, granule any one.

The formulation of different insecticides, the auxiliary material used is also different.In the Pesticide Science of those skilled in the art's accreditation, acceptable auxiliary material is all within protection scope of the present invention, and the present invention does not limit at this.

Solid carrier is filler, comprise in kaolin, clay, talcum powder, precipitated calcium carbonate, diatomite, white carbon, montmorillonite any one or multiple.

Liquid-carrier be solvent comprise in water, dimethyl formamide, methyl oleate, dimethyl carbonate, trimethylbenzene, methyl-pyrrolidon any one or multiple.

Auxiliary agent is emulsifier, wetting dispersing agent, defoamer, thickener, disintegrant and antifreezing agent, can also comprise the functional aid that the industry is conventional as required.Auxiliary agent comprises fatty alcohol-polyoxyethylene ether, lignosulfonates, naphthalene sulfonate, EO/PO block polyether, lignosulfonates, polymeric polycarboxylic acid salt, dioctyl sodium sulphosuccinate salt, phenolsulfonic acid condensation product sodium salt, fatty alcohol-polyoxyethylene ether, lauryl sodium sulfate, sodium lignin sulfonate, polymeric polycarboxylic acid salt, naphthalene sulfonic acid condensate sodium salt, polymeric polycarboxylic acid salt, methyl naphthalene sulfonate formaldehyde condensate, phenolsulfonic acid condensation product sodium salt, alkylnaphthalene sulfonate, sodium metnylene bis-naphthalene sulfonate, maleic-acrylic acid homopolymers sodium salt, calcium dodecyl benzene sulfonate, polycarboxylate, fat alcohol ethoxyl compound, calcium dodecyl benzene sulfonate, alkylphenol polyoxyethylene, cinnamic alcohol polyoxyethylene ether, in alkyl benzene sulfonate calcium salt any one or multiple.

Binding agent comprise in polyvinyl alcohol, xanthans, soluble starch, carboxymethyl cellulose any one or multiple.

Disintegrant comprise in sodium chloride, ammonium sulfate, sodium carbonate, sodium sulphate, ammonium chloride any one or multiple.

Thickener comprise in xanthans, Magnesiumaluminumsilicate, gum Arabic, polyvinyl alcohol any one or multiple.

Antifreezing agent comprise in glycerine, propane diols, urea, isopropyl alcohol, ethylene glycol any one or multiple.

Defoamer is organosilicon.

In addition, the present invention also provides described Pesticidal combination and the application of agricultural insecticide in agricultural or forest pest control.Application preferably on Lepidoptera and homoptera pest control, especially has special efficacy to rice leaf roller, aphid, snout moth's larva, striped rice borer, diamond-back moth, plant hopper, noctuid, flea beetle, cotton bollworm.

Owing to adopting technique scheme, beneficial effect of the present invention is:

1, composition of the present invention has obvious synergistic effect compared with single dose, Toxicity Determination result shows, to Lepidoptera and homoptera pest, there is significant synergistic function, especially to rice leaf roller, striped rice borer, diamond-back moth, rice fulgorid, prodenia litura limit ratio range in, synergy co-toxicity coefficient (CTC) is greater than 120.

2, the present composition is good to the control effects of damage by disease and insect, and preventive effect reaches more than 90%, and the consumption of composition is few relative to single dose consumption, and control mu is originally low, little on the impact of ecotope.

Embodiment:

Below by embodiment, the invention will be further described.It should be noted that, the embodiment of the present invention is only used for the present invention is described, instead of limitation of the present invention.In the following embodiments, insecticidal activity compound thiobenzamide all refers to the material of its chemistry bromo-N-of 3-[4-chloro-2-methyl-6-(methylamino thioformyl) benzene]-1-(3-chloropyridine-2-base)-1H-pyrazoles-5-formamide by name, thiobenzamide is laboratory synthesis, and other medicaments are commercial; Unless otherwise indicated, all percentage is all weight percentage.

Formulation Example:

One, the preparation of water dispersible granules

Method: after agricultural chemicals, dispersant, disintegrant, wetting agent, binding agent etc. are mixed, by air-flow crushing, granulating and forming.

Embodiment 1:20% thiobenzamide ethiprole water dispersible granules (1:1)

20% reactive compound (10% thiobenzamide and 10% composition containing fipronil), fatty alcohol-polyoxyethylene ether 4%, lignosulfonates 2%, sodium chloride 15%, polyvinyl alcohol 2%, kaolin complement to 100%, abundant mixing, pass through air-flow crushing again, granulating and forming must containing the water dispersible granules of 20% reactive compound, and product cut size is 0.8-2mm.

Embodiment 2:60% thiobenzamide chlopyrifos water dispersible granules (1:5)

60% reactive compound (10% thiobenzamide and 50% chlopyrifos composition), lignosulfonates 3%, naphthalene sulfonate 3%, ammonium sulfate 15%, xanthans 1%, talcum powder 1%, kaolin complement to 100%, abundant mixing, pass through air-flow crushing again, granulating and forming must containing the water dispersible granules of 60% reactive compound, and product cut size is 0.8-2mm.

Embodiment 3:33% thiobenzamide Affirm (Merck Co.) water dispersible granules (10:1)

33% reactive compound (30% thiobenzamide and 3% Affirm (Merck Co.) composition), EO/PO block polyether 4%, lignosulfonates 3.5%, soluble starch 5%, precipitated calcium carbonate 3%, diatomite complement to 100%, abundant mixing, pass through air-flow crushing again, granulating and forming must containing the water dispersible granules of 33% reactive compound, and product cut size is 0.8-2mm.

Embodiment 4:6.2% thiobenzamide Affirm (Merck Co.) water dispersible granules (30:1)

6.2% reactive compound (6% thiobenzamide and 0.2% Affirm (Merck Co.) composition), polymeric polycarboxylic acid salt 5%, lignosulfonates 1%, precipitated calcium carbonate 3%, diatomite complement to 100%, abundant mixing, pass through air-flow crushing again, granulating and forming must containing the water dispersible granules of 6.2% reactive compound, and product cut size is 0.8-2mm.

Embodiment 5:15.5% thiobenzamide Affirm (Merck Co.) water dispersible granules (1:30)

15.5% reactive compound (0.5% thiobenzamide and 15% Affirm (Merck Co.) composition), polymeric polycarboxylic acid salt, lignosulfonates 2.5%, soluble starch 5%, precipitated calcium carbonate 3%, diatomite complement to 100%, abundant mixing, pass through air-flow crushing again, granulating and forming must containing the water dispersible granules of 15.5% reactive compound, and product cut size is 0.8-2mm.

Embodiment 6:14% thiobenzamide Affirm (Merck Co.) water dispersible granules (13:1)

14% reactive compound (13% thiobenzamide and 1% Affirm (Merck Co.) composition), EO/PO block polyether 4%, lignosulfonates 3%, polyvinyl alcohol 2%, precipitated calcium carbonate 3%, diatomite complement to 100%, abundant mixing, pass through air-flow crushing again, granulating and forming must containing the water dispersible granules of 14% reactive compound, and product cut size is 0.8-2mm.

Embodiment 7:22% thiobenzamide Affirm (Merck Co.) water dispersible granules (1:10)

22% reactive compound (2% thiobenzamide and 20% Affirm (Merck Co.) composition), EO/PO block polyether 4%, polymeric polycarboxylic acid salt 3%, polyvinyl alcohol 2%, diatomite complement to 100%, abundant mixing, pass through air-flow crushing again, granulating and forming must containing the water dispersible granules of 22% reactive compound, and product cut size is 0.8-2mm.

Embodiment 8:40% thiobenzamide Affirm (Merck Co.) water dispersible granules (1:1)

40% reactive compound (20% thiobenzamide and 20% Affirm (Merck Co.) composition), dioctyl sodium sulphosuccinate salt 4%, lignosulfonates 3%, soluble starch 5%, sodium carbonate 2%, precipitated calcium carbonate 3%, diatomite complement to 100%, abundant mixing, pass through air-flow crushing again, granulating and forming must containing the water dispersible granules of 40% reactive compound, product cut size 0.8-2mm.

Embodiment 9:55% thiobenzamide Biphenthrin composition water dispersible granules (1:10)

55% reactive compound (5% thiobenzamide and 50% Biphenthrin composition), phenolsulfonic acid condensation product sodium salt 7%, fatty alcohol-polyoxyethylene ether 5%, sodium sulphate 6%, xanthans 1%, kaolin are complemented to 100%, abundant mixing, put into high shear homogenized milk agent high speed again and shear corase grind and homogeneous, sand milling in pump to sand mill again, sand milling is to certain particle diameter, granulation obtains the water dispersible granules containing 55% reactive compound again, and product cut size is 0.8-2mm.

Embodiment 10:31% thiobenzamide gamma cyhalothrin water dispersible granules (1:30)

31% reactive compound (1% thiobenzamide and 30% gamma cyhalothrin composition), phenolsulfonic acid condensation product sodium salt 4%, dioctyl sodium sulphosuccinate salt 3%, xanthans 1%, kaolin are complemented to 100%, abundant mixing, put into high shear homogenized milk agent high speed again and shear corase grind and homogeneous, sand milling in pump to sand mill again, sand milling is to certain particle diameter, granulating and forming must containing the water dispersible granules of 31% reactive compound again, and product cut size is 0.8-2mm.

Embodiment 11:60% thiobenzamide metaflumizone water dispersible granules (1:5)

60% reactive compound (10% thiobenzamide and 50% metaflumizone composition), phenolsulfonic acid condensation product sodium salt 4%, fatty alcohol-polyoxyethylene ether 6%, sodium chloride 11%, kaolin are complemented to 100%, abundant mixing, put into high shear homogenized milk agent high speed again and shear corase grind and homogeneous, sand milling in pump to sand mill again, sand milling is to certain particle diameter, granulating and forming must containing the water dispersible granules of 60% reactive compound again, and product cut size is 0.8-2mm.

Embodiment 12:33% thiobenzamide hexaflumuron water dispersible granule (10:1)

33% reactive compound (30% thiobenzamide and 3% HEXAFLUMURON composition), phenolsulfonic acid condensation product sodium salt 4%, fatty alcohol-polyoxyethylene ether 6%, ammonium sulfate 11%, xanthans 2%, diatomite are complemented to 100%, abundant mixing, put into high shear homogenized milk agent high speed again and shear corase grind and homogeneous, sand milling in pump to sand mill again, sand milling is to certain particle diameter, granulating and forming must containing the water dispersible granules of 33% reactive compound again, and product cut size is 0.8-2mm.

Two, the preparation of wetting powder

By recipe requirements, the ratio in formula such as former medicine, various auxiliary agent and filler is fully mixed, can obtain after ultra-fine pulverizer disintegrating.

Embodiment 13:22% thiobenzamide indoxacarb wetting powder (10:1)

22% reactive compound (20% thiobenzamide and 2% indoxacarb composition), lauryl sodium sulfate 4%, sodium lignin sulfonate 5%, white carbon 2%, kaolin are complemented to 100%, abundant mixing, again by ultra-fine grinding extremely certain particle diameter, obtain the wetting powder containing 22% reactive compound.

Embodiment 14:44% thiobenzamide metaflumizone wetting powder (10:1)

44% reactive compound (40% thiobenzamide and 4% metaflumizone composition), polymeric polycarboxylic acid salt 3%, talcum powder 1%, precipitated calcium carbonate 5%, kaolin are complemented to 100%, abundant mixing, again by ultra-fine grinding extremely certain particle diameter, obtain the wetting powder containing 44% reactive compound.

Embodiment 15:80% thiobenzamide wettable powder with buprofezin (1:29.8)

80% reactive compound (2.6% thiobenzamide and 77.4% buprofezin composition), naphthalene sulfonic acid condensate sodium salt 1%, polymeric polycarboxylic acid salt 2%, talcum powder 2%, precipitated calcium carbonate 5%, diatomite are complemented to 100%, abundant mixing, again by ultra-fine grinding extremely certain particle diameter, obtain the wetting powder containing 80% reactive compound.

Embodiment 16:22% thiobenzamide capillary wetting powder (1:10)

22% reactive compound (2% thiobenzamide and 20% capillary composition), naphthalene sulfonic acid condensate sodium salt 1%, polymeric polycarboxylic acid salt 2%, white carbon 2%, precipitated calcium carbonate 3%, kaolin are complemented to 100%, abundant mixing, again by ultra-fine grinding extremely certain particle diameter, obtain the wetting powder containing 22% reactive compound.

Embodiment 17:21% thiobenzamide Cupric sulfate wetting powder (1:20)

21% reactive compound (1% thiobenzamide and 20% monosultap composition), phenolsulfonic acid condensation product sodium salt 1%, polymeric polycarboxylic acid salt 2%, white carbon 3%, precipitated calcium carbonate 2%, diatomite are complemented to 100%, abundant mixing, again by ultra-fine grinding extremely certain particle diameter, obtain the wetting powder containing 21% reactive compound.

Embodiment 18:14% thiobenzamide pleocidin wetting powder (1:6)

14% reactive compound (2% thiobenzamide and 12% pleocidin composition), methyl naphthalene sulfonate formaldehyde condensate 1%, phenolsulfonic acid condensation product sodium salt 2%, white carbon 2%, precipitated calcium carbonate 3%, diatomite are complemented to 100%, abundant mixing, again by ultra-fine grinding extremely certain particle diameter, obtain the wetting powder containing 14% reactive compound.

Embodiment 19:22% thiobenzamide Avermectin wetting powder (1:10)

22% reactive compound (2% thiobenzamide and 20% abamectin composition), fatty alcohol-polyoxyethylene ether 5%, lignosulfonates 3%, kaolin complement to 100%, abundant mixing, must containing the wetting powder of 22% reactive compound again by ultra-fine grinding extremely certain particle diameter.

Embodiment 20:42% thiobenzamide Avermectin wetting powder (1:20)

42% reactive compound (2% thiobenzamide and 40% abamectin composition), fatty alcohol-polyoxyethylene ether 4%, methyl naphthalene sulfonate formaldehyde condensate 4%, white carbon 10%, kaolin complement to 100%, abundant mixing by ultra-fine grinding extremely certain particle diameter, obtains the wetting powder containing 42% reactive compound again.

Embodiment 21:62% thiobenzamide Avermectin wetting powder (1:30)

62% reactive compound (2% thiobenzamide and 60% abamectin composition), phenolsulfonic acid condensation product sodium salt 4%, lignosulfonates 3%, white carbon 5%, kaolin complement to 100%, abundant mixing by ultra-fine grinding extremely certain particle diameter, obtains the wetting powder containing 62% reactive compound again.

Embodiment 22:31% thiobenzamide Avermectin wetting powder (30:1)

31% reactive compound (30% thiobenzamide and 1% abamectin composition), fatty alcohol-polyoxyethylene ether 4%, lignosulfonates 3%, kaolin complement to 100%, abundant mixing by ultra-fine grinding extremely certain particle diameter, obtains the wetting powder containing 31% reactive compound again.

Embodiment 23:22% thiobenzamide Avermectin wetting powder (10:1)

22% reactive compound (20% thiobenzamide and 2% abamectin composition), methyl naphthalene sulfonate formaldehyde condensate 1%, polymeric polycarboxylic acid salt 2%, white carbon 2%, precipitated calcium carbonate 3%, diatomite are complemented to 100%, abundant mixing, again by ultra-fine grinding extremely certain particle diameter, obtain the wetting powder containing 22% reactive compound.

Embodiment 24:1% thiobenzamide Avermectin wetting powder (1:1)

1% reactive compound (0.5% thiobenzamide and 0.5% abamectin composition), fatty alcohol-polyoxyethylene ether 4%, lignosulfonates 3%, white carbon 6%, kaolin complement to 100%, abundant mixing by ultra-fine grinding extremely certain particle diameter, obtains the wetting powder containing 1% reactive compound again.

Embodiment 25:32% thiobenzamide beta-cypermethrin wetting powder (15:1)

32% reactive compound (30% thiobenzamide and 2% beta-cypermethrin composition), lauryl sodium sulfate 4%, sodium lignin sulfonate 5%, white carbon 2%, kaolin are complemented to 100%, abundant mixing, again by ultra-fine grinding extremely certain particle diameter, obtain the wetting powder containing 32% reactive compound.

Embodiment 26:62% thiobenzamide beta-cypermethrin wetting powder (30:1)

62% reactive compound (60% thiobenzamide and 2% beta-cypermethrin composition), lauryl sodium sulfate 4%, sodium lignin sulfonate 5%, white carbon 2%, kaolin are complemented to 100%, abundant mixing, again by ultra-fine grinding extremely certain particle diameter, obtain the wetting powder containing 62% reactive compound.

Embodiment 27:80% thiobenzamide beta-cypermethrin wetting powder (7:9)

80% reactive compound (35% thiobenzamide and 45% beta-cypermethrin composition) fatty alcohol-polyoxyethylene ether 4%, EO/PO block polyether 2%, naphthalene sulfonic acid condensate sodium salt 2%, kaolin are complemented to 100%, abundant mixing, again by ultra-fine grinding extremely certain particle diameter, obtain the wetting powder containing 80% reactive compound.

Three, the preparation of suspending agent

Embodiment 28:40% thiobenzamide diafenthiuron suspension agent (5:3)

40% reactive compound (25% thiobenzamide and 15% diafenthiuron composition), fatty alcohol-polyoxyethylene ether 2%, alkylnaphthalene sulfonate 3%, sodium metnylene bis-naphthalene sulfonate 1%, maleic-acrylic acid homopolymers sodium salt 3%, xanthans 0.05%, Magnesiumaluminumsilicate 0.6%, glycerine 2%, Phenylsalicylate 0.4%, organosilicon 0.1%, water are mended to 100%, put into high shear homogeneous emulsifying machine high speed and shear 20 minutes, transport to again in sand mill, the suspending agent that namely circulation sand milling obtains containing 40% reactive compound for 1-3 time.

Embodiment 29:7% thiobenzamide Avermectin suspending agent (5:2)

7% reactive compound (5% thiobenzamide and 2% abamectin composition), EO/PO block polyether 2%, sodium metnylene bis-naphthalene sulfonate 2%, polymeric polycarboxylic acid salt 4%, aluminium-magnesium silicate 1%, urea 2%, organosilicon 0.1%, water are mended to 100%, put into high shear homogeneous emulsifying machine high speed and shear 30 minutes, transport to again in sand mill, the suspending agent that namely circulation sand milling obtains containing 7% reactive compound for 1-3 time.

Embodiment 30:6% thiobenzamide dimehypo suspending agent (1:5)

6% reactive compound (1% thiobenzamide and 5% dimehypo composition), cinnamic alcohol polyoxyethylene ether 5%, fat alcohol ethoxyl compound 2%, polyvinyl alcohol 0.5%, ethylene glycol 5%, organosilicon 0.2%, water are mended to 100%, put into high shear homogeneous emulsifying machine high speed and shear 30 minutes, transport to again in sand mill, the suspending agent that namely circulation sand milling obtains containing 6% reactive compound for 1-3 time.

Embodiment 31:3% thiobenzamide Avermectin suspending agent (1:5)

3% reactive compound (0.5% thiobenzamide and 2.5% abamectin composition) sodium metnylene bis-naphthalene sulfonate 2%, alkylphenol polyoxyethylene 4%, xanthans 0.2%, isopropyl alcohol 4%, silicone defoaming agent 0.1%, deionized water are mended to 100%, put into high shear homogeneous emulsifying machine high speed and shear 30 minutes, transport to again in sand mill, the suspending agent that namely circulation sand milling obtains containing 3% reactive compound for 1-3 time.

Embodiment 32:4% thiobenzamide Ivermectin HCL suspending agent (1:1)

4% reactive compound (2% thiobenzamide and 2% Ivermectin HCL composition) dioctyl sodium sulphosuccinate salt 2%, maleic-acrylic acid homopolymers sodium salt 1%, alkylphenol polyoxyethylene 5%, gum Arabic 0.2%, propane diols 4%, organosilicon 0.2%, deionized water are mended to 100%, put into high shear homogeneous emulsifying machine high speed and shear 30 minutes, transport to again in sand mill, the suspending agent that namely circulation sand milling obtains containing 4% reactive compound for 1-3 time.

Four, the preparation of aqueous emulsion

Embodiment 33:4% thiobenzamide high performance aqueous emulsion of cypermethrin (2:3)

By 4% reactive compound (2% thiobenzamide and 3% beta-cypermethrin composition), 12% dimethyl formamide joins mixing kettle, be added in after stirring and dissolving in mixing kettle and add EO/PO block polyether 2%, polycarboxylate 4%, calcium dodecyl benzene sulfonate 2%, stir, obtain oil phase, stand-by.In high shear still, add glycerine 3% and defoamer 0.1%, running water (supplying 100%), stirs, obtains aqueous phase.In high shear still, add oil phase, start clipper, high shear agitation 30 minutes, obtains milky white liquid, is the aqueous emulsion containing 4% reactive compound.

Five, the preparation of missible oil

Embodiment 34:22% thiobenzamide r (1:10)

By 22% reactive compound (2% thiobenzamide and 20% beta-cypermethrin composition), 8% dimethyl formamide joins mixing kettle, fat alcohol ethoxyl compound 6% is added after stirring and dissolving, calcium dodecyl benzene sulfonate 3%, methyl oleate is supplied and is stirred, and obtains the missible oil containing 22% reactive compound.

Embodiment 35:6.2% thiobenzamide r (1:30)

By 6.2% reactive compound (0.2% thiobenzamide and 6% beta-cypermethrin composition), 5% cyclohexanone joins mixing kettle, fatty alcohol-polyoxyethylene ether 7% is added after stirring and dissolving, calcium dodecyl benzene sulfonate 3%, solvent naphtha is supplied and is stirred, and obtains the missible oil containing 6.2% reactive compound.

Embodiment 36:22% thiobenzamide efficient cyhalothrin emulsifiable concentrate (10:1)

By 22% reactive compound (20% thiobenzamide and 2% gamma cyhalothrin composition), 12% dimethyl formamide joins mixing kettle, emulsifier alkylphenol polyoxyethylene 8% is added after stirring and dissolving, calcium dodecyl benzene sulfonate 3%, trimethylbenzene is supplied and is stirred, and obtains the missible oil containing 22% reactive compound.

Embodiment 37:12% thiobenzamide chlorpyrifos ec (5:1)

By 12% reactive compound (10% thiobenzamide and 2% chlopyrifos composition), 8% dimethyl formamide joins mixing kettle, emulsifier EO/PO block polyether 7% is added after stirring and dissolving, calcium dodecyl benzene sulfonate 3%, dimethyl carbonate is supplied and is stirred, and obtains the missible oil containing 12% reactive compound.

Embodiment 38:22% thiobenzamide quintiofos cream (1:10)

By 22% reactive compound (2% thiobenzamide and 20% quinalphos composition), 10% dimethyl formamide joins mixing kettle, emulsifier alkylphenol polyoxyethylene 7% is added after stirring and dissolving, calcium dodecyl benzene sulfonate 3%, solvent naphtha is supplied and is stirred, and obtains the missible oil containing 22% reactive compound.

Embodiment 39:5% thiobenzamide Profenofos missible oil (2:3)

By 5% reactive compound (2% thiobenzamide and 3% Profenofos composition), 12% cyclohexanone joins mixing kettle, fatty alcohol-polyoxyethylene ether 7% is added after stirring and dissolving, calcium dodecyl benzene sulfonate 3%, trimethylbenzene is supplied and is stirred, and obtains the missible oil containing 5% reactive compound.

Embodiment 40:15% thiobenzamide triazophos emulsifiable solution (2:13)

By 15% reactive compound (2% thiobenzamide and 13% Hostathion composition), 8% dimethyl formamide joins mixing kettle, cinnamic alcohol polyoxyethylene ether 8% is added after stirring and dissolving, alkyl benzene sulfonate calcium salt 3%, methyl oleate is supplied and is stirred, and obtains the missible oil containing 15% reactive compound.

Embodiment 41:2.2% thiobenzamide malathion missible oil (3:8)

By 2.2% reactive compound (0.6% thiobenzamide and 1.6% malathion composition), 4% cyclohexanone joins mixing kettle, emulsifier EO/PO block polyether 5% is added after stirring and dissolving, calcium dodecyl benzene sulfonate 2%, trimethylbenzene is supplied and is stirred, and obtains the missible oil containing 2.2% reactive compound.

Six, the preparation of granule

Embodiment 42:1% thiobenzamide Biphenthrin granule (1:4)

By 1% reactive compound (0.2% thiobenzamide and 0.8% Biphenthrin composition), 4% alkylphenol polyoxyethylene, 3% urea, 5% polyvinyl alcohol, kaolin is supplied 100% and to be stirred pulverizing, then extruder grain, obtains the granule containing 1% reactive compound.

Embodiment 43:7% thiobenzamide chlopyrifos granule (1:6)

7% reactive compound (1% thiobenzamide and 6% chlopyrifos composition) is dissolved in 10% methyl-pyrrolidon, 3% lauryl alcohol polyethylene glycol oxide base ether, 2.5% alkyl benzene sulfonate calcium salt, 2% carboxymethyl cellulose, 1% ammonium sulfate mixes, then add water and adopt the mode of high-pressure fog to be sprayed onto load weighted 74.5% montmorillonite, after abundant stirring and adsorbing drying, obtain the granule containing 7% reactive compound.

Embodiment 44:10% thiobenzamide Affirm (Merck Co.) granule (1:4)

By 10% reactive compound (2% thiobenzamide and 8% Affirm (Merck Co.) composition), 5% polyoxyethylene nonylphenol ether, 3% sodium chloride, 15% soluble starch, diatomite is supplied 100% and to be stirred pulverizing, then extruder grain, obtains the granule containing 10% reactive compound.

Embodiment 45:15% thiobenzamide Abamectin (1:2)

By 15% reactive compound (5% thiobenzamide and 10% abamectin composition), 6% sodium lignin sulfonate, 10% ammonium chloride, 1% carboxymethyl cellulose, clay is supplied 100% and to be stirred pulverizing, then extruder grain, obtains the granule containing 15% reactive compound.

Bioassay test:

Data processing method: control efficiency is converted into probability value (y), liquor strength (μ g/ml) converts logarithm value (x) to, calculate virulence equation and concentration LC50 in suppressing with method of least squares, calculate toxicity index and the co-toxicity coefficient (CTC) of medicament according to the abundant method of Sun Yun.

When CTC≤80, then composition shows as antagonism, and as 80 < CTC < 120, then composition shows as summation action, and when CTC >=120, then composition shows as synergistic effect.

Actual measurement toxicity index (ATI)=(standard agent LC50/ reagent agent LC50) × 100

In theoretical toxicity index (TTI)=A medicament toxicity index × mixture A percentage composition+B medicament toxicity index × mixture in the percentage composition of B

Co-toxicity coefficient (CTC)=[the theoretical toxicity index (TTI) of mixture actual measurement toxicity index (ATI)/mixture] × 100

Biologicall test example 1: Pesticidal combination is tested the Toxicity Determination of diamond-back moth

Test method: adopt leaf dipping method, with reference to " NY/T 1154.14-2008 farm-chemical indoor determination test rule insecticide the 14th part: leaf dipping method ".

Table 1 thiobenzamide and beta-cypermethrin mixture are to the toxicity test of diamond-back moth

Process	LC50(μg/ml)	ATI	TTI	CTC
					Thiobenzamide (A)	0.74	100.00	/	/
Beta-cypermethrin (B)	24.15	3.06	/	/
					A:B＝30:1	0.61	121.31	96.87	125.23
A:B＝20:1	0.60	123.33	95.38	129.30
					A:B＝10:1	0.60	123.33	91.19	135.25
A:B＝2:1	0.76	97.37	67.69	143.85
					A:B＝1:1	0.88	84.09	51.53	163.18
A:B＝1:2	1.32	56.06	35.38	158.47
					A:B＝1:10	4.07	18.18	11.88	153.09
A:B＝1:20	7.22	10.25	7.68	133.45
					A:B＝1:30	9.73	7.61	6.19	122.84

Experimental result shows: thiobenzamide and efficient cypermethrin compounded, has synergistic effect during mixed ratio 1:30 ~ 30:1.

Table 2 thiobenzamide and chlorpyrifos mixture match the toxicity test of diamond-back moth

Process	LC50(μg/ml)	ATI	TTI	CTC
					Thiobenzamide (A)	0.72	100.00	/	/
Chlopyrifos (C)	50.12	1.44	/	/
					A:C＝30:1	0.61	118.03	96.82	121.91
A:C＝20:1	0.56	128.57	95.31	134.90
					A:C＝10:1	0.55	130.91	91.04	143.79
A:C＝5:1	0.58	124.14	83.57	148.54
					A:C＝1:1	0.94	76.60	50.72	151.02
A:C＝1:5	2.63	27.38	17.86	153.25
					A:C＝1:10	4.46	16.14	10.40	155.27
A:C＝1:20	8.32	8.65	6.13	141.17

A:C＝1:30

11.99

6.01

4.62

130.09

Experimental result shows: thiobenzamide and chlorpyrifos mixture, and during mixed ratio 1:30 ~ 30:1, synergistic effect is obvious.

Table 3 thiobenzamide and Biphenthrin mixture are to the toxicity test of diamond-back moth

Process	LC50(μg/ml)	ATI	TTI	CTC
					Thiobenzamide (A)	0.78	100.00	/	/
Biphenthrin (D)	1.89	41.27	/	/
					A:D＝30:1	0.59	132.20	98.11	134.76
A:D＝20:1	0.56	139.29	97.20	143.29
					A:D＝9:1	0.54	144.44	94.13	153.46
A:D＝4:1	0.54	144.44	88.25	163.67
					A:D＝1:1	0.65	120.00	70.63	169.89
A:D＝1:4	0.94	82.98	53.02	156.52
					A:D＝1:10	1.14	68.42	46.61	146.80
A:D＝1:20	1.31	59.54	44.07	135.12
					A:D＝1:30	1.45	53.79	43.16	124.62

Experimental result shows: thiobenzamide and Biphenthrin composite, have synergistic effect during mixed ratio 1:30 ~ 30:1.

Table 4 thiobenzamide and indoxacarb mixture are to the toxicity test of diamond-back moth

Process	LC50(μg/ml)	ATI	TTI	CTC
					Thiobenzamide (A)	0.70	100.00	/	/
Indoxacarb (E)	0.43	162.79	/	/
					A:E＝30:1	0.54	129.63	102.03	127.06
A:E＝20:1	0.5	140.00	102.99	135.94
					A:E＝10:1	0.47	148.94	105.71	140.89
A:E＝3:1	0.4	175.00	115.70	151.26
					A:E＝1:1	0.34	205.88	131.40	156.69
A:E＝1:3	0.3	233.33	147.09	158.63
					A:E＝1:10	0.28	250.00	157.08	159.15
A:E＝1:20	0.28	250.00	159.80	156.44
					A:E＝1:30	0.31	225.81	160.77	140.46

Experimental result shows: thiobenzamide and indoxacarb composite, have synergistic effect during mixed ratio 1:30 ~ 30:1.

Table 5 thiobenzamide and Cupric sulfate mixture are to the toxicity test of diamond-back moth

Process	LC50(μg/ml)	ATI	TTI	CTC
					Thio phenyl formyl (A)	0.78	100.00	/	/
Cupric sulfate (F)	185.21	0.42	/	/
					A:F＝30:1	0.6	130.00	96.79	134.31
A:F＝20:1	0.58	134.48	95.26	141.18
					A:F＝10:1	0.59	132.20	90.95	145.36
A:F＝1:1	0.99	78.79	50.21	156.91
					A:F＝1:10	5.09	15.32	9.47	161.75
A:F＝1:20	10.39	7.51	5.16	145.40
					A:F＝1:30	15.8	4.94	3.63	135.87

Experimental result shows: thiobenzamide and Cupric sulfate composite, have synergistic effect during mixed ratio 1:30 ~ 30:1.

Table 6 thiobenzamide and diafenthiuron mixture are to the toxicity test of diamond-back moth

Process	LC50(μg/ml)	ATI	TTI	CTC
					Thio phenyl formyl (A)	0.75	100.00	/	/
Diafenthiuron (G)	13.58	5.52	/	/
					A:G＝30:1	0.6	125.00	96.95	128.93
A:G＝20:1	0.58	129.31	95.50	135.40
					A:G＝10:1	0.58	129.31	91.41	141.46
A:G＝10:4	0.7	107.14	73.01	146.76
					A:G＝1:1	0.88	85.23	52.76	161.53
A:G＝4:10	1.46	51.37	32.52	157.98
					A:G＝1:10	3.52	21.31	14.11	150.99
A:G＝1:20	5.49	13.66	10.02	136.32
					A:G＝1:30	7.09	10.58	8.57	123.43

Experimental result shows: thiobenzamide and diafenthiuron composite, have synergistic effect during mixed ratio 1:30 ~ 30:1.

Biologicall test example 2 Pesticidal combination is tested the toxicity test of rice leaf roller

Experimental technique: adopt dip method, with reference to " NYT 1154.6-2006 farm-chemical indoor determination test rule insecticide the 6th part: insecticidal activity is tested ".

Table 7 thiobenzamide and Avermectin mixture are to the toxicity test of rice leaf roller

Process	LC50(μg/ml)	ATI	TTI	CTC
					Thiobenzamide (A)	0.86	100.00	/	/
Avermectin (H)	2.24	38.39	/	/
					A:H＝30:1	0.72	119.44	98.01	121.87
A:H＝20:1	0.66	130.30	97.07	134.24
					A:H＝15:1	0.58	148.28	96.15	154.21
A:H＝10:1	0.65	132.31	94.40	140.16
					A:H＝5:1	0.69	124.64	89.73	138.90
A:H＝2:1	0.75	114.67	79.46	144.30
					A:H＝1:1	0.83	103.61	69.20	149.74
A:H＝1:2	1.01	85.15	58.93	144.49
					A:H＝1:5	1.18	72.88	48.66	149.77
A:H＝1:10	1.05	81.90	43.99	186.17
					A:H＝1:15	1.24	69.35	42.24	164.18
A:H＝1:20	1.50	57.33	41.33	138.73
					A:H＝1:30	1.70	50.59	40.38	125.28

Experimental result shows: thiobenzamide and abamectin compounded, has synergistic effect during mixed ratio 1:30 ~ 30:1 to rice leaf roller.

Table 8 thiobenzamide and ethiprole mixture are to the toxicity test of rice leaf roller

Process	LC50(μg/ml)	ATI	TTI	CTC
					Thiobenzamide (A)	0.81	100.00	/	/
Ethiprole (K)	8.01	10.11	/	/
					A:K＝30:1	0.68	119.12	97.10	122.67
A:K＝18:1	0.66	122.73	95.27	128.82
					A:K＝10:1	0.62	130.65	91.83	142.27
A:K＝1:1	1.07	75.70	55.06	137.50
					A:K＝1:10	3.04	26.64	18.28	145.73
A:K＝1:18	3.91	20.72	14.84	139.57
					A:K＝1:30	4.73	17.12	13.01	131.61

Experimental result shows: thiobenzamide and Firponil compounded, all has synergistic effect during mixed ratio 1:30 ~ 30:1 to rice leaf roller.

Table 9 thiobenzamide and Hostathion mixture are to the toxicity test of rice leaf roller

Process	LC50(μg/ml)	ATI	TTI	CTC
					Thiobenzamide (A)	0.90	100.00	/	/
Hostathion (L)	158.15	0.57	/	/
					A:L＝30:1	0.71	126.76	96.79	130.96
A:L＝20:1	0.69	130.43	95.27	136.92
					A:L＝10:1	0.58	155.17	90.96	170.59
A:L＝1:1	1.08	83.33	50.28	165.72
					A:L＝1:10	5.97	15.08	9.61	156.90
A:L＝1:20	11.14	8.08	5.30	152.32
					A:L＝1:30	16.4	5.49	3.78	145.31

Experimental result shows: thiobenzamide and Triazoxide as built-up, has synergistic effect during mixed ratio 1:30 ~ 30:1.

Table 10 thiobenzamide and gamma cyhalothrin mixture are to the toxicity test of rice leaf roller

Process	LC50(μg/ml)	ATI	TTI	CTC
					Thiobenzamide (A)	0.84	100.00	/	/
Gamma cyhalothrin (M)	5.11	16.44	/	/
					A:M＝30:1	0.64	131.25	97.30	134.89
A:M＝20:1	0.67	125.37	96.02	130.57
					A:M＝10:1	0.61	137.70	92.40	149.03
A:M＝2:1	0.70	120.00	72.15	166.33
					A:M＝1:1	0.95	88.42	58.22	151.88
A:M＝1:2	1.33	63.16	44.29	142.59
					A:M＝1:10	2.34	35.90	24.03	149.36
A:M＝1:20	2.86	29.37	20.42	143.85
					A:M＝1:30	3.38	24.85	19.13	129.89

Experimental result shows: thiobenzamide and high-efficient lambda-cyhalothrin compound, has synergistic effect during mixed ratio 1:30 ~ 30:1.

Table 11 thiobenzamide and indoxacarb mixture are to the toxicity test of rice leaf roller

Process	LC50(μg/ml)	ATI	TTI	CTC
					Thiobenzamide (A)	0.86	100.00	/	/
Indoxacarb (N)	0.98	87.76	/	/
					A:N＝30:1	0.67	128.36	99.61	128.87
A:N＝20:1	0.64	134.38	99.42	135.16
					A:N＝10:1	0.61	140.98	98.89	142.57
A:N＝1:1	0.59	145.76	93.88	155.27
					A:N＝1:10	0.64	134.38	88.87	151.21
A:N＝1:20	0.68	126.47	88.34	143.17
					A:N＝1:30	0.72	119.44	88.15	135.50

Experimental result shows: thiobenzamide and indoxacarb composite, have synergistic effect during mixed ratio 1:30 ~ 30:1.

Table 12 thiobenzamide and Affirm (Merck Co.) mixture are to rice leaf roller toxicity test

Process	LC50(μg/ml)	ATI	TTI	CTC
					Thiobenzamide (A)	0.78	100.00	/	/
Affirm (Merck Co.) (P)	1.13	69.03	/	/
					A:P＝30:1	0.63	123.81	99.00	125.06
A:P＝20:1	0.59	132.20	98.53	134.18
					A:P＝15:1	0.56	139.29	98.06	142.04
A:P＝10:1	0.57	136.84	97.18	140.81
					A:P＝5:1	0.59	132.20	94.84	139.40
A:P＝3:1	0.58	134.48	92.26	145.77
					A:P＝1:1	0.63	123.81	84.51	146.50
A:P＝1:3	0.64	121.88	76.77	158.75
					A:P＝1:5	0.72	108.33	74.19	146.02
A:P＝1:10	0.69	113.04	71.84	157.35
					A:P＝1:15	0.75	104.00	70.96	146.56
A:P＝1:20	0.79	98.73	70.50	140.05
					A:P＝1:30	0.87	89.66	70.03	128.03

Experimental result shows: thiobenzamide and Affirm (Merck Co.) composite, have synergistic effect to rice leaf roller during mixed ratio 1:30 ~ 30:1.

Table 13 thiobenzamide and metaflumizone mixture are to the toxicity test of rice leaf roller

Process	LC50(μg/ml)	ATI	TTI	CTC
					Thiobenzamide (A)	0.73	100.00	/	/
Metaflumizone (Q)	7.53	9.69	/	/
					A:Q＝30:1	0.57	128.07	97.09	131.91
A:Q＝25:1	0.51	143.14	96.53	148.29
					A:Q＝20:1	0.49	148.98	95.70	155.67
A:Q＝15:1	0.46	158.70	94.36	168.19
					A:Q＝10:1	0.39	187.18	91.79	203.92
A:Q＝4:1	0.48	152.08	81.94	185.61
					A:Q＝1:1	0.76	96.05	54.85	175.13
A:Q＝1:4	1.55	47.10	27.76	169.68
					A:Q＝1:10	2.76	26.45	17.90	147.73
A:Q＝1:15	3.14	23.25	15.34	151.57
					A:Q＝1:20	3.50	20.86	13.99	149.03
A:Q＝1:25	3.88	18.81	13.17	142.88
					A:Q＝1:30	4.32	16.90	12.61	134.03

Experimental result shows: thiobenzamide and metaflumizone composite, have synergistic effect during mixed ratio 1:30 ~ 30:1.

Biologicall test example 3 Pesticidal combination is tested the toxicity test of striped rice borer

With reference to " NYT 1154.6-2006 farm-chemical indoor determination test rule insecticide the 6th part: insecticidal activity test dip method "

Table 14 thiobenzamide and Affirm (Merck Co.) mixture are to striped rice borer toxicity test

Process	LC50(μg/ml)	ATI	TTI	CTC
					Thiobenzamide (A)	4.71	100.00	/	/
Affirm (Merck Co.) (R)	1.08	436.11	/	/
					A:R＝30:1	3.35	140.60	110.84	126.84
A:R＝20:1	3.03	155.45	116.01	134.00
					A:R＝9:1	2.49	189.16	133.61	141.57
A:R＝2:1	1.1	428.18	212.04	201.94

A:R＝1:1	0.92	511.96	268.06	190.99
					A:R＝1:2	0.86	547.67	324.07	169.00
A:R＝1:10	0.75	628.00	405.56	154.85
					A:R＝1:20	0.79	596.20	420.11	141.92
A:R＝1:30	0.83	567.47	425.27	133.44

Experimental result shows: thiobenzamide and Affirm (Merck Co.) composite, have synergistic effect to striped rice borer during mixed ratio 1:30 ~ 30:1.

Table 15 thiobenzamide and Avermectin mixture are to striped rice borer toxicity test

Process	LC50(μg/ml)	ATI	TTI	CTC
					Thiobenzamide (A)	4.56	100.00	/	/
Avermectin (S)	1.97	231.47	/	/
					A:S＝30:1	3.19	142.95	104.24	137.13
A:S＝20:1	3.05	149.51	106.26	140.70
					A:S＝10:1	2.91	156.70	111.95	139.97
A:S＝3:1	2.36	193.22	132.87	145.42
					A:S＝1:1	1.79	254.75	165.74	153.71
A:S＝1:3	1.63	279.75	198.60	140.86
					A:S＝1:10	1.17	389.74	219.52	177.54
A:S＝1:20	1.52	300.00	225.21	133.21
					A:S＝1:30	1.64	278.05	227.23	122.36

Experimental result shows: thiobenzamide and abamectin compounded, has synergistic effect during mixed ratio 1:30 ~ 30:1 to striped rice borer.

Table 16 thiobenzamide and Ivermectin HCL mixture are to striped rice borer toxicity test

Process	LC50(μg/ml)	ATI	TTI	CTC
					Thiobenzamide (A)	4.8	100.00	/	/
Ivermectin HCL (T)	2.15	223.26	/	/
					A:T＝30:1	3.74	128.34	103.98	123.43
A:T＝20:1	3.46	138.73	105.87	131.04
					A:T＝10:1	3.02	158.94	111.21	142.93
A:T＝2:1	2.33	206.01	141.09	146.02

A:T＝1:1	2	240.00	161.63	148.49
					A:T＝1:2	1.63	294.48	182.17	161.65
A:T＝1:10	1.58	303.80	212.05	143.27
					A:T＝1:20	1.64	292.68	217.39	134.64
A:T＝1:30	1.76	272.73	219.28	124.37

Experimental result shows: thiobenzamide and Ivermectin HCL composite, have synergistic effect during mixed ratio 1:30 ~ 30:1.

Table 17 thiobenzamide and ethiprole mixture are to striped rice borer toxicity test

Process	LC50(μg/ml)	ATI	TTI	CTC
					Thiobenzamide (A)	4.79	100.00	/	/
Ethiprole (U)	3.51	136.47	/	/
					A:U＝30:1	3.86	124.09	101.18	122.65
A:U＝20:1	3.69	129.81	101.74	127.59
					A:U＝10:1	2.69	178.07	103.32	172.35
A:U＝1:1	2.94	162.93	118.23	137.80
					A:U＝1:10	2.5	191.60	133.15	143.90
A:U＝1:20	2.68	178.73	134.73	132.66
					A:U＝1:30	2.87	166.90	135.29	123.36

Experimental result shows: thiobenzamide and Firponil compounded, has synergistic effect during mixed ratio 1:30 ~ 30:1.

Table 18 thiobenzamide and pleocidin mixture are to striped rice borer toxicity test

Process	LC50(μg/ml)	ATI	TTI	CTC
					Thiobenzamide (A)	4.91	100.00	/	/
Pleocidin (V)	1.03	476.70	/	/
					A:V＝30:1	3.57	137.54	112.15	122.63
A:V＝20:1	3.21	152.96	117.94	129.69
					A:V＝8:1	2.59	189.58	141.86	133.64
A:V＝1:1	1.17	419.66	288.35	145.54
					A:V＝1:8	0.84	584.52	434.84	134.42
A:V＝1:20	0.8	613.75	458.76	133.78
					A:V＝1:30	0.84	584.52	464.55	125.83

Experimental result shows: thiobenzamide and pleocidin compound, has synergistic effect during mixed ratio 1:30 ~ 30:1.

Table 19 thiobenzamide and chlorpyrifos mixture match striped rice borer toxicity test

Process	LC50(μg/ml)	ATI	TTI	CTC
					Thiobenzamide (A)	4.78	100.00	/	/
Chlopyrifos (W)	44.56	10.73	/	/
					A:W＝30：1	3.95	121.01	97.12	124.60
A:W＝20：1	3.86	123.83	95.75	129.33
					A:W＝10：1	4.02	118.91	87.25	136.29
A:W＝1：1	5.95	80.34	55.36	145.11
					A:W＝1：6	11.49	41.60	23.48	177.18
A:W＝1：20	20.17	23.70	14.98	158.22
					A:W＝1：30	27.92	17.12	13.61	125.82

Experimental result shows: thiobenzamide and chlorpyrifos mixture, has synergistic effect during mixed ratio 1:30 ~ 30:1.

Table 20 thiobenzamide and Profenofos mixture are to striped rice borer toxicity test

Process	LC50(μg/ml)	ATI	TTI	CTC
					Thiobenzamide (A)	4.83	100.00	/	/
Profenofos (X)	208.95	2.31	/	/
					A:X＝30:1	4.04	119.55	96.85	123.44
A:X＝20:1	3.96	121.97	95.35	127.92
					A:X＝10:1	2.97	162.63	91.12	178.48
A:X＝1:1	6.45	74.88	51.16	146.38
					A:X＝1:10	28.42	17.00	11.19	151.85
A:X＝1:20	49.6	9.74	6.96	139.84
					A:X＝1:30	68.38	7.06	5.46	129.30

Experimental result shows: thiobenzamide and Profenofos composite, have synergistic effect during mixed ratio 1:30 ~ 30:1.

Table 21 thiobenzamide and dimehypo mixture are to striped rice borer toxicity test

Process	LC50(μg/ml)	ATI	TTI	CTC
					Thiobenzamide (A)	4.89	100.00	/	/
Dimehypo (Y)	120.25	4.07	/	/
					A:Y＝30:1	3.84	127.34	96.91	131.41
A:Y＝20:1	3.65	133.97	95.43	140.39

A:Y＝10:1	3.39	144.25	91.28	158.03
					A:Y＝1:1	5.69	85.94	52.03	165.16
A:Y＝1:10	25.44	19.22	12.79	150.31
					A:Y＝1:20	39.84	12.27	8.63	142.15
A:Y＝1:30	50.53	9.68	7.16	135.14

Experimental result shows: thiobenzamide and dimehypo composite, have synergistic effect during mixed ratio 1:30 ~ 30:1.

Biologicall test example 4 Pesticidal combination is tested the toxicity test of prodenia litura

Experimental technique: with reference to NYT 1154.14-2008 farm-chemical indoor determination test rule insecticide the 14th part: leaf dipping method.

Table 22 thiobenzamide and capillary mixture are to prodenia litura toxicity test

Process	LC50(μg/ml)	ATI	TTI	CTC
					Thiobenzamide (A)	1.03	100.00	/	/
Capillary (Z)	13.12	7.85	/	/
					A:Z＝30:1	0.83	124.10	97.03	127.90
A:Z＝20:1	0.76	135.53	95.61	141.75
					A:Z＝10:1	0.74	139.19	91.62	151.92
A:Z＝5:1	0.78	132.05	84.64	156.01
					A:Z＝1:1	1.21	85.12	53.93	157.86
A:Z＝1:5	2.92	35.27	23.21	151.99
					A:Z＝1:10	3.35	30.75	16.23	189.47
A:Z＝1:20	5.5	18.73	12.24	153.02
					A:Z＝1:30	6.49	15.87	10.82	146.64

Experimental result shows: thiobenzamide and capillary composite, have synergistic effect during mixed ratio 1:30 ~ 30:1.

Table 23 thiobenzamide and HEXAFLUMURON mixture are to prodenia litura toxicity test

Process	LC50(μg/ml)	ATI	TTI	CTC
					Thiobenzamide (A)	0.95	100.00	/	/
HEXAFLUMURON (XX)	2.25	42.22	/	/
					A:XX＝30:1	0.78	121.79	98.14	124.11
A:XX＝20:1	0.72	131.94	97.25	135.68
					A:XX＝10:1	0.68	139.71	94.75	147.45

A:XX＝4:1	0.62	153.23	88.44	173.25
					A:XX＝1:1	0.95	100.00	71.11	140.63
A:XX＝1:4	1.19	79.83	53.78	148.45
					A:XX＝1:10	1.31	72.52	47.47	152.75
A:XX＝1:20	1.43	66.43	44.97	147.72
					A:XX＝1:30	1.63	58.28	44.09	132.20

Experimental result shows: thiobenzamide and hexaflumuron compounded, has synergistic effect during mixed ratio 1:30 ~ 30:1.

Table 24 thiobenzamide and quinalphos mixture are to prodenia litura toxicity test

Process	LC50(μg/ml)	ATI	TTI	CTC
					Thiobenzamide (A)	0.98	100.00	/	/
Quinalphos (XY)	88.15	1.11	/	/
					A:XY＝30:1	0.77	127.27	96.81	131.47
A:XY＝20:1	0.74	132.43	95.29	138.98
					A:XY＝10:1	0.74	132.43	91.01	145.51
A:XY＝1:1	1.29	75.97	50.56	150.27
					A:XY＝1:10	6.77	14.48	10.10	143.30
A:XY＝1:20	12.42	7.89	5.82	135.56
					A:XY＝1:30	18.14	5.40	4.30	125.60

Experimental result shows: thiobenzamide and quinalphos composite, have synergistic effect during mixed ratio 1:30 ~ 30:1.

Table 25 thiobenzamide and indoxacarb mixture are to prodenia litura toxicity test

Process	LC50(μg/ml)	ATI	TTI	CTC
					Thiobenzamide (A)	0.92	100.00	/	/
Indoxacarb (XZ)	0.75	122.67	/	/
					A:XZ＝30:1	0.73	126.03	100.73	125.11
A:XZ＝20:1	0.69	133.33	101.08	131.91
					A:XZ＝14:1	0.56	164.29	101.51	161.84
A:XZ＝10:1	0.67	137.31	102.06	134.54
					A:XZ＝1:1	0.57	161.40	111.33	144.97
A:XZ＝1:10	0.48	191.67	120.61	158.92
					A:XZ＝1:14	0.5	184.00	121.16	151.87

A:XZ＝1:20	0.53	173.58	121.59	142.77
					A:XZ＝1:30	0.58	158.62	121.94	130.09

Experimental result shows: thiobenzamide and indoxacarb composite, have synergistic effect during mixed ratio 1:30 ~ 30:1.

Biologicall test example 5 Pesticidal combination is to rice fulgorid toxicity test test (rice-stem dipping method)

Experimental technique: with reference to People's Republic of China (PRC) agricultural industry criteria NY/T 1154.11-2008 farm-chemical indoor determination test rule insecticide the 11st part .I rice-stem dipping method.

Table 26 thiobenzamide and Buprofezin mixture are to rice fulgorid toxicity test

Process	LC50(μg/ml)	ATI	TTI	CTC
					Thiobenzamide (A)	38.11	100.00	/	/
Buprofezin (YY)	16.54	230.41	/	/
					A:YY＝30:1	29.24	130.34	104.21	125.07
A:YY＝20:1	26.95	141.41	106.21	133.14
					A:YY＝15:1	23.08	165.12	108.15	152.68
A:YY＝10:1	23.47	162.38	111.86	145.17
					A:YY＝1:1	14.45	263.74	165.21	159.64
A:YY＝1:10	10.56	360.89	218.56	165.13
					A:YY＝1:15	11.23	339.36	222.26	152.69
A:YY＝1:20	11.97	318.38	224.20	142.01
					A:YY＝1:30	12.41	307.09	226.20	135.76

Experimental result shows: thiobenzamide and buprofezin compound, has synergistic effect during mixed ratio 1:30 ~ 30:1.

Table 27 thiobenzamide and malathion mixture are to rice fulgorid toxicity test

Process	LC50(μg/ml)	ATI	TTI	CTC
					Thiobenzamide (A)	38.25	100.00
Malathion (ZZ)	20.12	190.11
					A:ZZ＝30:1	30.40	125.82	102.91	122.27
A:ZZ＝20:1	28.16	135.83	104.29	130.24
					A:ZZ＝10:1	25.34	150.95	108.19	139.52
A:ZZ＝1:1	18.44	207.43	145.05	143.00
					A:ZZ＝1:10	15.74	243.01	181.92	133.58
A:ZZ＝1:20	16.45	232.52	185.82	125.13

A:ZZ＝1:30

16.95

225.66

187.20

120.55

Experimental result shows: thiobenzamide and malathion composite, have synergistic effect during mixed ratio 1:30 ~ 30:1.

Field trial embodiment 1

Experimental subjects: the rice leaf roller of test occurs in abiogenous population in periphery rice field, Village, Xixiangtang District, Nanning in May, 2013.

Test method: in the tillering stage (mid-May) of paddy rice morning, all medicaments are by actual dosage, and the medication of every mu adds the water of 60L, after stirring evenly evenly sprays liquid in rice clump top.With reference to GB/T 17980.2-2000 pesticide field efficacy medicine test criterion (one) insecticide control rice leaf roller.

Test specimen:

Contrast medicament 1:1.8% abamectin emulsifiable concentrate, Guangxi Tianyuan Biochemical Co., Ltd., registration card number: PD20097649

Contrast medicament 2:6% indoxacarb microemulsion, Shanggezhilu Biosciences Co., Ltd., Shaanxi, registration card number: LS20130025

Contrast medicament 3:40% chlorpyrifos ec, Yangtze River, Anhui Chemical Co., Ltd., registration card number: PD20080226

Contrast medicament 4:10% quintiofos cream, Jiangxi crowd and Chemical Co., Ltd., registration card number: PD20085043

Contrast medicament 5:5% Affirm (Merck Co.) missible oil, Jinan City, Shandong Province Shi Bang agrochemical Co., Ltd, registration card number: PD20100833

Contrast medicament 6:50% Profenofos missible oil, Shanghai Vegcides Bio-farm (Nanchang) Co., Ltd., registration card number: PD20110070

Contrast medicament 7:20% triazophos emulsifiable solution, Jiangxi Zheng Bang biochemical industry Co., Ltd, registration card number: PD20040387,

Contrast medicament 8:45% malathion missible oil, Jiangxi Wei Niu crop science Co., Ltd, registration card number: PD20080002

Contrast medicament 9:2.5% efficient cyhalothrin emulsifiable concentrate, Jiangsu Fengdeng Pesticide Co., Ltd., registration card number: PD20080059

Contrast medicament 10:4.5% Biphenthrin emulsion in water, West of Chengdu Ai Di crop science Co., Ltd, registration card number: LS20120011

Contrast medicament 11:5% high performance aqueous emulsion of cypermethrin, Jiangsu Dongbao Pesticide Chemical Co., Ltd., registration card number: PD20040082

Contrast medicament 12:25% dimehypo water solution, Anhui Huaxing Chemical Co., Ltd., registration card number: PD20084448

The solvable pulvis of contrast medicament 13:50% Cupric sulfate, Jiangsu Tianrong Group Co., Ltd., registration card number: PD20050160

Contrast medicament 14:8% pleocidin aqueous emulsion, Beijing Yanhua Yongle Biotechnology Co., Ltd., registration card number: LS20130303

Contrast medicament 15:0.5% Ivermectin HCL missible oil, Zhejiang Hisun Chemical Co., Ltd, registration card number: PD20120411

Contrast medicament 16:5% 5 percent of hexaflumuron emulsifiable concentrate, Dezhou Lv Ba Fine Chemical Co., Ltd, registration card number: PD20090603

Contrast medicament 17:25% diafenthiuron suspension agent, Shandong Zhaofengnian Bio-Technology Co., Ltd., registration card number: LS20120361

Contrast medicament 18:5% thiobenzamide SC (self-control);

Compound method: thiobenzamide 5%, fatty alcohol-polyoxyethylene ether 4.0%, EO/PO block polyether 2.0%, sodium metnylene bis-naphthalene sulfonate 2.0%, polymeric polycarboxylic acid salt 4.0%, polyvinyl alcohol 0.5%, urea 2.0%, silicone defoaming agent 0.1%, deionized water are mended to 100%, put into high shear homogeneous emulsifying machine high speed and shear 30 minutes, transport to again in sand mill, circulation sand milling 1-3 time and get final product.

The test of pesticide effectiveness result of rice leaf roller prevented and treated by table 28

From above field trial, the compound synergic effect of the present composition is obvious.Composite rear preventive effect is apparently higher than each contrast medicament.

Field trial embodiment 2

Subjects: occur in abiogenous population in periphery rice field, Wuming County Li Jian town, Nanning in May, 2013.

Dispenser period: the early tillering stage (mid-May) of paddy rice.

Test method: with reference to GB/T 17980.4-2000 pesticide field efficacy medicine test criterion (one) insecticide control rice fulgorid

Test specimen:

Contrast medicament 19:10% capillary suspending agent, BASF European Co., Ltd, registration card number: PD20080477

Contrast medicament 20:5% ethiprole suspending agent, BASF European Co., Ltd, registration card number: PD20110148

Contrast medicament 21:25% wettable powder with buprofezin, east wind pesticide chemical factory of Taixing City of Jiangsu Province, registration card number: PD20060051

Contrast medicament 22:22% metaflumizone suspending agent, BASF European Co., Ltd, registration card number: PD20101191.

The test of pesticide effectiveness result of rice fulgorid prevented and treated by table 29

From above field efficacy, the compound synergic effect of the present composition is obvious.Composite rear preventive effect is apparently higher than each contrast medicament.

The compound synergic effect of the present composition, is not limited to the activity experiment listed by invention.Verified composition of the present invention, all has good preventive effect to other Lepidopteras and homoptera pest, especially has special efficacy to aphid, snout moth's larva, striped rice borer, diamond-back moth, plant hopper, noctuid, flea beetle, cotton bollworm.It is a kind of insecticide of wide spectrum.

Although the bromo-N-of reactive compound I 3-[4-chloro-2-methyl-6-(methylamino thioformyl) benzene]-1-(3-chloropyridine-2-base)-1H-pyrazoles-5-formamide and elite insecticidal active compound II are known compound in the present invention, above-mentioned reactive compound is composite is then non-obvious with the more outstanding insecticidal effect realized desired by the present invention for those skilled in the art.

Claims (10)

1., containing the Pesticidal combination of thiobenzamide, it is characterized in that: described Pesticidal combination is made up of insecticidal active compound I and insecticidal active compound II; Wherein, insecticidal active compound I is thiobenzamide, its chemistry bromo-N-of 3-[4-chloro-2-methyl-6-(methylamino thioformyl) benzene]-1-(3-chloropyridine-2-base)-1H-pyrazoles-5-formamide by name; Insecticidal active compound II is selected from any one of compound in following II.1-II.5;

II.1) organophosphorus insecticides;

II.2) pyrethroid insecticides;

II.3) sandworm toxin insecticide;

II.4) antibiotic insecticide;

II.5) other insecticides: be selected from the one in indoxacarb, capillary, ethiprole, Buprofezin, HEXAFLUMURON, diafenthiuron, metaflumizone;

The weight ratio of insecticidal active compound I and insecticidal active compound II is 1:30 ~ 30:1.

2. the Pesticidal combination containing thiobenzamide according to claim 1, is characterized in that: described organophosphorus insecticides is the one in chlopyrifos, Profenofos, Hostathion, malathion, quinalphos.

3. the Pesticidal combination containing thiobenzamide according to claim 1, is characterized in that: described pyrethroid insecticides is the one in gamma cyhalothrin, Biphenthrin, beta-cypermethrin.

4. the Pesticidal combination containing thiobenzamide according to claim 1, is characterized in that: described sandworm toxin insecticide is the one in dimehypo, Cupric sulfate.

5. the Pesticidal combination containing thiobenzamide according to claim 1, is characterized in that: described antibiotic insecticide is the one in Affirm (Merck Co.), Avermectin, pleocidin, Ivermectin HCL.

6. the Pesticidal combination containing thiobenzamide according to any one of claim 1-5, is characterized in that: the weight ratio of described insecticidal active compound I and insecticidal active compound II is 1:10 ~ 10:1.

7. an agricultural insecticide, it is characterized in that: described agricultural insecticide forming containing the Pesticidal combination of thiobenzamide and auxiliary material according to any one of claim 1-6, wherein, described Pesticidal combination accounts for 1% ~ 80% of described agricultural insecticide gross weight.

8. a kind of agricultural insecticide according to claim 7, is characterized in that: described Pesticidal combination accounts for 20% ~ 60% of described agricultural insecticide gross weight.

9. a kind of agricultural insecticide according to claim 7 or 8, is characterized in that: the formulation of described agricultural insecticide is wetting powder, water dispersible granules, missible oil, aqueous emulsion, suspending agent or granule.

10. the application of a kind of agricultural insecticide according to any one of claim 7-9 in control agricultural or forestry pest.