CN104436075A

CN104436075A - Pharmaceutical composition for treating myocarditis and application of pharmaceutical composition

Info

Publication number: CN104436075A
Application number: CN201410815818.9A
Authority: CN
Inventors: 不公告发明人
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-12-24
Filing date: 2014-12-24
Publication date: 2015-03-25

Abstract

The invention discloses a pharmaceutical composition for treating myocarditis. The pharmaceutical composition is mainly prepared from the following raw materials: pseudo-ginseng, red peony root, semen boitae, fructus forsythiae, astragalus membranaceus, coriander, willow branch, david poplar twig, peach juvenile branchlet, rhizoma phragmitis, rhizoma atractylodis, junci medulla, flowers carthami, ligusticum wallichii, curcuma zedoary, radix ophiopogonis, radix curcumae, allium macrostemon, cassia twig, radix pseudostellariae, trichosanthes kirilowii, lophatherum gracile, rhizoma arisaematis, honey-fried licorice root, cortex albiziae, schisandra chinensis, salviae miltiorrhizae, rhiizoma cimicifugae foetidae, blackend swallowwort root, herba cistanche, suberect spatholobus stem, herba portulacae and seed of feather cockscomb. The pharmaceutical composition has the efficacies of tonifying qi, nourishing vigor, strengthening body resistance to dispel pathogenic factors, nourishing the heart and dredging veins, is capable of regulating the immune function in two ways, is effectively controlling various myocarditis symptoms, protecting the cardiac muscle and promoting myocardial function recovery, and is significant in curative effect.

Description

One treats myocarditic pharmaceutical composition and application thereof

Technical field

The present invention relates to a kind of pharmaceutical composition, be specifically related to one and treat myocarditic pharmaceutical composition and application thereof.

Background technology

Myocarditis refers to have limitation or diffuse acute, subacute or chronic inflammatory lesion in cardiac muscle.The relative incidence rate of viral myocarditis constantly increases in recent years.State of an illness weight is different, and show widely different, how heavier the infant state of an illness is, and adult is how comparatively light, and the lighter can without obvious condition of illness, and severe one can concurrent severe arrhythmia, and cardiac insufficiency is even died suddenly.The prodrome of acute stage or subacute stage myocarditis, patient can have heating, tired, hyperhidrosis, nervous, out of breath, precordial fullness pain etc.Check the arrhythmia such as visible premature beat, conduction block, glutamic oxaloacetic transaminase, GOT, creatine phosphokinase increase, and erythrocyte sedimentation rate speeds.Myocarditis can be primary in cardiac muscle, may also be a part for systemic disease.Myocarditis clinical symptoms: 1. symptom: tired, heating, uncomfortable in chest, cardiopalmus, breathe hard, dizzy, cardiac insufficiency or cardiogenic shock can be there is in severe patient; 2. sign: increased heart rate, raises disproportionate with body temperature, and heart circle expands, and noise changes, arrhythmia.

Myocarditic classification has: viral myocarditis, Children Myocarditis, hypertrophic myocarditis, toxic myocarditis, dilated myocarditis, parasitic myocarditis, bacterial infection myocarditis.

Viral myocarditis: pathogenic factor can be caused by multiple viral infection, wherein the most common with Coxsackie virus B, chickenpox, Epstein-Barr virus also can cause.According to the study, heart generation myocarditis can be involved after about having 5% viral infection person to infect.Can be the cardiac muscle of the direct invasion and attack after viral infection, also can be caused by the autoimmune response after viral infection, the former is common with child, and the latter is common with teenager, and spring is season occurred frequently of viral myocarditis.Its clinical symptoms just has upper respiratory tract infection or intestinal infection symptom for sick, occurs the symptoms such as uncomfortable in chest, cardiopalmus, extremely weak, easy perspiration after 7 ~ 10 days.Now, as having an electro-cardiogram, the arrhythmias such as premature beat and cardiac damage performance may be found that there is.Make erythrocyte sedimentation rate, myocardium enzyme measures and may raise.Look into Coxsackie virus antibody after 2-4 week, antimyocardial antibody can be the positive.

Children Myocarditis: Children Myocarditis patient, often first develops signs of a cold, as fever, cough, pharyngalgia, watery nasal discharge, general malaise, nausea and vomiting, stomachache, diarrhoea, some also has arthralgia, myalgia.These symptoms take a turn for the better gradually or disappear at leisure, and the sign of heart abnormality starts to occur: palpitating speed or obviously slow down, or occur stopping fighting, irregular.The lethargy of baby, green around the gills, unable, hyperhidrosis, inappetence or repeatedly occur nausea and vomiting, epigastrium pain; Or tell headache, dizziness, cardiopalmus, uncomfortable in chest, pareordia is uncomfortable or pain.The performance of the cardiac dysfunctions such as severe patient is also shown in face edema, it is sleeping to put down, tachypnea.Some baby can unexpected heart beating slack-off, per minute only have 20 ~ 30 times, result in acute cerebral ischemia, causes convulsion to show effect or unexpected to occur, directly threatening life.

Hypertrophic myocarditis: myocardial cell has had defect, heart wall can be thicker.In severe cases, the heart wall of enlargement may hinder blood flow to and flow out heart.This disease is just hypertrophic cardiomyopathy.Its symptom is suffer from the patient of hypertrophic myocarditis easily to occur the phenomenons such as tired, chest pain, tachypnea and cardiopalmus.

Toxic myocarditis: refer to the myocardial inflammation caused by toxin or poisonous substance, except the infectious disease extracellular toxins such as diphtheria, typhoid fever, bacillary dysentery, endotoxin on myocardial infringement, some biotoxin is as snake venom, poisonous fungus, Fugu ocellatus, Aconitum carmichjaelii Debx. etc., and some drugs or chemical substance are as quinidine, quinine, emetine, antimony agent, organophosphor, organic mercury, arsenic, carbon monoxide, lead, Ah enzyme's element etc., and cardiac damage all can be caused to produce toxic myocarditis.A part of important behaviour of toxic myocarditis systemic toxicity profiles often, the critical or concurrent severe cardiac functional defect of the state of an illness and arrhythmia person's mortality rate high, in time, effectively rescue and often can save patients ' lives.Its symptom and sign is: 1. the symptom of cardiac insufficiency, as cardiopalmus, breathe hard, body and pulmonary circulation blood stasis sign; 2. ARR performance.

Dilated myocarditis: dilated myocarditis heart often increases, cardiac dilatation is the most obvious with bilateral ventricle, thus claims dilated myocarditis; dilatation of heart is the lighter comparatively, and ventricle wall slightly thickens, pathological development; expansion increases the weight of, and ventricle wall is relatively thinning, and ventricular wall thickness normally or slightly thickens.Due to myocardial fibrosis, amyocardia, ejection fraction declines, and semilunar valve mouth may occur that function is narrow, and left and right ventricles is expanded, AO relative incompetence can be caused, blood flow repeated stock causes chamber valve and slightly thickens, and cardiomyopathy can extend to endocardium, and the rising local blood supply insufficiency of intracardiac local pressure, can cause endocardium plaque-like fibrous thickening, the case of about 60% has mural thrombus to be formed.

Parasitic myocarditis common are following two types: 1. toxoplasma myocarditis.This kind of myocarditis is caused by infection by Toxoplasma gondii.The mankind mainly infect because eating containing not the boiling meat of encapsulation.After toxoplasma enters human body, menses flow to and reach mononuclear phagocyte system and various tissue, and at propagated in cells.Toxoplasma is bred after invading myocardial cell very soon, forms aggregation, also known as pseudocyst.Myocardial cell breaks very soon, and pathogen enters surrounding tissue.Lymphocyte, monocyte infiltration is had around destroyed myocardial cell.Cicatrization is had after more multiple.About half patient because of heart failure lethal; 2.Chagas myocarditis.This kind of myocarditis is caused by protozoon Ku Shi Trypanosoma cruzi infection, is popular in Latin America various countries.Be in a bad way, mortality rate is high.Stove shape or dispersivity myocardial necrosis can be caused, have lymphocyte, monocyte infiltration around.Dilatation of heart, ventricle wall (mainly in apical region of heart) is thinning, often forms ventricular aneurysm, with the included wall thrombosis of the chambers of the heart.

Bacterial myocarditis: some myocarditis can by antibacterial direct infection, or bacteriogenic toxin is to the effect of cardiac muscle, or allergy caused by bacterial product and causing: 1. abscess,myocardial is often caused by pyogenic baeceria, as staphylococcus, streptococcus, Diplococcus pneumoniae, meningococcus etc.Pyogenic baeceria derives from transitivity bacterial clump during pyaemia septica, or from suppurative Thromboembolus during bacterial endocarditis.Naked eyes are seen, heart surface and the visible multiple yellow microabscess of tangent plane, have congested band around.Under mirror, abscess myocardium necrocytosis liquefies, the bacteria colonies having a large amount of pus cell and quantity not in vomica etc.Abscess surrounding myocardium has degeneration in various degree, necrosis, has neutrophilic granulocyte and monocyte infiltration in interstitial; 2. diphtheria corynebacterium can produce extracellular toxin, on the one hand the protein synthesis of myocardial cell ribosome capable of blocking, and the long-chain fatty acid of carnitine mediation capable of blocking is on the other hand transported into mitochondrion, causes myocardial cell steatosis and necrosis.Under mirror, visible stove shape muscular degeneration of heart is downright bad, and myocardial cell occurs that the cohesion of acidophile degeneration, sarcoplasm, steatosis and sarcoplasm dissolve.The visible lymphocyte of intralesional, mononuclear cell and minority neutrophil infiltration.Focus is more common in right ventricle wall, forms the little cicatrix of fine mesh after more multiple.There is diffusivity myocardial necrosis in some cases, can cause sudden cardiac death; 3. when upper respiratory tract streptococcal infection (acute angina, tonsillitis) and scarlet fever, can the non-rheumatic myocarditis of complicated with acute.Its pathogenesis is not yet clear, may be to be caused by streptococcus toxin.Pathological changes is interstitial myocarditis.Under mirror, have lymphocyte, monocyte infiltration in cardiac interstitium connective tissue and around thin vessels, myocardial cell has degeneration, the necrosis of varying degree.

At present, modern medicine there is no effective Therapeutic Method to viral myocarditis.The clinical manifestation of viral myocarditis is different, and myocarditic symptom may come across symptom phase or the convalescent period of protopathy, and as the symptom phase in protopathy occurs, its performance can be covered by protopathy.Most of patients has the symptoms such as heating, systemic pain, pharyngalgia, diarrhoea at premorbid, and reflection systemic viral infects, but also has some patients protopathy mild symptoms and remarkable, and must carefully be noted the side of questioning closely, myocarditis symptom is then more remarkable.Patients with myocarditis often tells uncomfortable in chest, pareordia dull pain, cardiopalmus, weak, nauseating, dizzy.In the myocarditis diagnosed clinically, about 90% to be chief complaint with arrhythmia or head is shown in symptom, and wherein small number of patients can occur to faint or Adams Stokes syndrome therefrom.Only a few patient plays development after being ill and rapidly, occurs heart failure or cardiogenic shock.About there is the patient of 60% ~ 88% about morbidity the last fortnight, had the pioneer such as sense or diarrhoea in heating, pharyngalgia, general pain etc. current, viral myocarditis has become the commonly encountered diseases of medical science medical field, hazardness is very big, but there is no the Chinese medicine preparation of drug administration by injection safely and effectively so far; Do not have effective experience side clinically, flavour of a drug are more, and all adopt decoct oral, also do not have Chinese medicine injection dosage form, slow to drug absorption for the more not only body of peroral dosage form, and use also inconvenient.Directly have influence on therapeutic effect and the scope of application of the type medicine.Infantile viral myocarditis then more adopts western medicine antibiotics, and such as oral ribavirin, intravenous injection inosine, aspara, vitamin C etc., its general effect is not obvious, and cure rate is low, and toxic and side effects is large.But in the Chinese medicine that China is traditional, the medicine that never curative effect is very definite, most of Chinese patent medicine is all carry out flavour of a drug plus-minus on the basis of Empirical formula, and in conjunction with the remedy measures of doctor trained in Western medicine.Both do not carry out deep research for disease, do not develop the new Chinese medicine with unique curative effect yet.

Summary of the invention

The present invention is directed to weak point of the prior art, provide one to treat myocarditic pharmaceutical composition and application thereof.

Above-mentioned purpose of the present invention is realized by following technical proposals:

One treats myocarditic pharmaceutical composition, raw material composition and the parts by weight of making described pharmaceutical composition are: Radix Notoginseng 7-13 part, Radix Paeoniae Rubra 6-12 part, Semen Platycladi 2-5 part, Fructus Forsythiae 7-13 part, Radix Astragali 13-19 part, Herba Coriandri 20-25 part, Ramulus Salicis Babylonicae 28-36 part, Ramulus Populi Davidianae 10-18 part, Ramulus Persicae 17-30 part, Rhizoma Phragmitis 34-45 part, Rhizoma Atractylodis 10-16 part, Medulla Junci 2-5 part, Flos Carthami 5-8 part, Rhizoma Chuanxiong 30-35 part, Rhizoma Curcumae 30-35 part, Radix Ophiopogonis 11-16 part, Radix Curcumae 11-18 part, Bulbus Allii Macrostemonis 20-25 part, Ramulus Cinnamomi 5-6 part, Radix Pseudostellariae 10-15 part, Fructus Trichosanthis 26-34 part, Herba Lophatheri 12-18 part, Rhizoma Arisaematis 20-25 part, Radix Glycyrrhizae Preparata 3-4 part, Cortex Albiziae 3-9 part, Fructus Schisandrae Chinensis 4-7 part, Radix Salviae Miltiorrhizae 10-12 part, RHIIZOMA CIMICIFUGAE FOETIDAE 11-15 part, Radix Cynanchi Atrati 10-16 part, Herba Cistanches 10-15 part, Caulis Spatholobi 17-44 part, Herba Portulacae 15-40 part, Semen Celosiae 8-32 part.

Further, raw material composition and the parts by weight of making described pharmaceutical composition are: Radix Notoginseng 13 parts, Radix Paeoniae Rubra 10 parts, Semen Platycladi 3 parts, Fructus Forsythiae 7 parts, the Radix Astragali 19 parts, Herba Coriandri 25 parts, Ramulus Salicis Babylonicae 36 parts, Ramulus Populi Davidianae 18 parts, Ramulus Persicae 30 parts, Rhizoma Phragmitis 45 parts, Rhizoma Atractylodis 16 parts, Medulla Junci 2 parts, 7 parts, Flos Carthami, Rhizoma Chuanxiong 35 parts, Rhizoma Curcumae 30 parts, Radix Ophiopogonis 16 parts, Radix Curcumae 13 parts, Bulbus Allii Macrostemonis 25 parts, Ramulus Cinnamomi 5 parts, Radix Pseudostellariae 15 parts, Fructus Trichosanthis 30 parts, Herba Lophatheri 16 parts, Rhizoma Arisaematis 23 parts, Radix Glycyrrhizae Preparata 3 parts, Cortex Albiziae 9 parts, Fructus Schisandrae Chinensis 7 parts, Radix Salviae Miltiorrhizae 12 parts, RHIIZOMA CIMICIFUGAE FOETIDAE 15 parts, Radix Cynanchi Atrati 10 parts, Herba Cistanches 15 parts, Caulis Spatholobi 17 parts, Herba Portulacae 15 parts, Semen Celosiae 8 parts.

Further, raw material composition and the parts by weight of making described pharmaceutical composition are: Radix Notoginseng 11 parts, Radix Paeoniae Rubra 12 parts, Semen Platycladi 3.5 parts, Fructus Forsythiae 8 parts, the Radix Astragali 17 parts, Herba Coriandri 22 parts, Ramulus Salicis Babylonicae 32 parts, Ramulus Populi Davidianae 16 parts, Ramulus Persicae 30 parts, Rhizoma Phragmitis 40 parts, Rhizoma Atractylodis 12 parts, Medulla Junci 3 parts, 5 parts, Flos Carthami, Rhizoma Chuanxiong 35 parts, Rhizoma Curcumae 33 parts, Radix Ophiopogonis 16 parts, Radix Curcumae 13 parts, Bulbus Allii Macrostemonis 20 parts, Ramulus Cinnamomi 5 parts, Radix Pseudostellariae 13 parts, Fructus Trichosanthis 31 parts, Herba Lophatheri 16 parts, Rhizoma Arisaematis 23 parts, Radix Glycyrrhizae Preparata 3 parts, Cortex Albiziae 3 parts, Fructus Schisandrae Chinensis 5 parts, Radix Salviae Miltiorrhizae 10 parts, RHIIZOMA CIMICIFUGAE FOETIDAE 15 parts, Radix Cynanchi Atrati 10 parts, Herba Cistanches 12 parts, Caulis Spatholobi 41 parts, Herba Portulacae 40 parts, Semen Celosiae 32 parts.

Further, raw material composition and the parts by weight of making described pharmaceutical composition are: Radix Notoginseng 9 parts, Radix Paeoniae Rubra 10 parts, Semen Platycladi 4.5 parts, Fructus Forsythiae 8.5 parts, the Radix Astragali 15 parts, Herba Coriandri 20 parts, Ramulus Salicis Babylonicae 28 parts, Ramulus Populi Davidianae 11 parts, Ramulus Persicae 30 parts, Rhizoma Phragmitis 40 parts, Rhizoma Atractylodis 11 parts, Medulla Junci 3.5 parts, 5.5 parts, Flos Carthami, Rhizoma Chuanxiong 35 parts, Rhizoma Curcumae 35 parts, Radix Ophiopogonis 12 parts, Radix Curcumae 11 parts, Bulbus Allii Macrostemonis 20 parts, Ramulus Cinnamomi 5 parts, Radix Pseudostellariae 11 parts, Fructus Trichosanthis 34 parts, Herba Lophatheri 18 parts, Rhizoma Arisaematis 23 parts, Radix Glycyrrhizae Preparata 3.5 parts, Cortex Albiziae 3 parts, Fructus Schisandrae Chinensis 5 parts, Radix Salviae Miltiorrhizae 10 parts, RHIIZOMA CIMICIFUGAE FOETIDAE 15 parts, Radix Cynanchi Atrati 10 parts, Herba Cistanches 12 parts, Caulis Spatholobi 25 parts, Herba Portulacae 25 parts, Semen Celosiae 28 parts.

Further, raw material composition and the parts by weight of making described pharmaceutical composition are: Radix Notoginseng 15 parts, Radix Paeoniae Rubra 8 parts, Semen Platycladi 4 parts, Fructus Forsythiae 9 parts, the Radix Astragali 19 parts, Herba Coriandri 25 parts, Ramulus Salicis Babylonicae 30 parts, Ramulus Populi Davidianae 10 parts, Ramulus Persicae 20 parts, Rhizoma Phragmitis 40 parts, Rhizoma Atractylodis 10 parts, Medulla Junci 3 parts, 6 parts, Flos Carthami, Rhizoma Chuanxiong 35 parts, Rhizoma Curcumae 30 parts, Radix Ophiopogonis 11 parts, Radix Curcumae 13 parts, Bulbus Allii Macrostemonis 20 parts, Ramulus Cinnamomi 5 parts, Radix Pseudostellariae 15 parts, Fructus Trichosanthis 30 parts, Herba Lophatheri 12 parts, Rhizoma Arisaematis 20 parts, Radix Glycyrrhizae Preparata 3 parts, Cortex Albiziae 8 parts, Fructus Schisandrae Chinensis 5 parts, Radix Salviae Miltiorrhizae 10 parts, RHIIZOMA CIMICIFUGAE FOETIDAE 15 parts, Radix Cynanchi Atrati 12 parts, Herba Cistanches 10 parts, Caulis Spatholobi 29 parts, Herba Portulacae 35 parts, Semen Celosiae 30 parts.

Further, raw material composition and the parts by weight of making described pharmaceutical composition are: Radix Notoginseng 11 parts, Radix Paeoniae Rubra 9 parts, Semen Platycladi 5 parts, Fructus Forsythiae 10 parts, the Radix Astragali 18 parts, Herba Coriandri 20 parts, Ramulus Salicis Babylonicae 32 parts, Ramulus Populi Davidianae 12 parts, Ramulus Persicae 21 parts, Rhizoma Phragmitis 40 parts, Rhizoma Atractylodis 13 parts, Medulla Junci 3.5 parts, 6 parts, Flos Carthami, Rhizoma Chuanxiong 35 parts, Rhizoma Curcumae 30 parts, Radix Ophiopogonis 11 parts, Radix Curcumae 13 parts, Bulbus Allii Macrostemonis 22 parts, Ramulus Cinnamomi 6 parts, Radix Pseudostellariae 12 parts, Fructus Trichosanthis 30 parts, Herba Lophatheri 12 parts, Rhizoma Arisaematis 20 parts, Radix Glycyrrhizae Preparata 3 parts, Cortex Albiziae 9 parts, Fructus Schisandrae Chinensis 4 parts, Radix Salviae Miltiorrhizae 11 parts, RHIIZOMA CIMICIFUGAE FOETIDAE 11 parts, Radix Cynanchi Atrati 10 parts, Herba Cistanches 10 parts, Caulis Spatholobi 40 parts, Herba Portulacae 20 parts, Semen Celosiae 24 parts.

Further, raw material composition and the parts by weight of making described pharmaceutical composition are: Radix Notoginseng 10 parts, Radix Paeoniae Rubra 6 parts, Semen Platycladi 2 parts, Fructus Forsythiae 13 parts, the Radix Astragali 13 parts, Herba Coriandri 23 parts, Ramulus Salicis Babylonicae 31 parts, Ramulus Populi Davidianae 11 parts, Ramulus Persicae 17 parts, Rhizoma Phragmitis 34 parts, Rhizoma Atractylodis 15 parts, Medulla Junci 5 parts, 8 parts, Flos Carthami, Rhizoma Chuanxiong 30 parts, Rhizoma Curcumae 32 parts, Radix Ophiopogonis 15 parts, Radix Curcumae 18 parts, Bulbus Allii Macrostemonis 22 parts, Ramulus Cinnamomi 5 parts, Radix Pseudostellariae 10 parts, Fructus Trichosanthis 26 parts, Herba Lophatheri 15 parts, Rhizoma Arisaematis 25 parts, Radix Glycyrrhizae Preparata 4 parts, Cortex Albiziae 8 parts, Fructus Schisandrae Chinensis 5 parts, Radix Salviae Miltiorrhizae 12 parts, RHIIZOMA CIMICIFUGAE FOETIDAE 15 parts, Radix Cynanchi Atrati 16 parts, Herba Cistanches 15 parts, Caulis Spatholobi 23 parts, Herba Portulacae 35.5 parts, Semen Celosiae 12 parts.

The invention still further relates to a kind of preparation method for the treatment of myocarditic pharmaceutical composition, be specially following steps:

(1) extract each raw material of Chinese medicine medicine according to the arbitrary described parts by weight proportioning of claim 1-7, be then jointly carefully ground into medicamental pulverata, for subsequent use;

(2) medicamental pulverata getting grinding in step (1) is positioned in marmite and adds water, the water yield is 4 times of medicamental pulverata weight, then with big fire by after water boil 4-6min, change little fire to decoct, stir medicamental pulverata when decocting, stirring number of times is 2-3 time, and decocting time is 30-45min, rear elimination medicinal residues are decocted, taking liquid.

Or described preparation method is specially following steps:

(1) extract each raw material of Chinese medicine medicine according to the arbitrary described parts by weight proportioning of claim 1-7 and decoct with water 2 times, first time 2-2.5 hour, second time 1.5 hours, filtrate merging decocts 1 hour again, leaves standstill 30 hours, again filters, filter, it is 1.05 that filtrate is concentrated into relative density;

(2) step (1) gained filtrate is added ethanol, ethanol consumption is 1.5 times of filtrate quality, abundant mix homogeneously, leaves standstill cold preservation 25-30 hour, and filter, after filtrate recycling ethanol, then continuing to be concentrated into thick paste, is 1.40 to relative density;

(3) get appropriate Icing Sugar and dry 1-2 hour in 60 DEG C, be placed in appropriate vessel, add gained thick paste stirring and evenly mixing in step (2), being modulated into soft durometer is that hands is pinched agglomerating, the soft material that light pressure is then loose, and 14 mesh sieves crossed by soft material, make wet granular;

(4) by the wet granular bake drying that step (3) is made, baking temperature is 80 DEG C, and after cooling, sealing is stand-by.

The invention still further relates to a kind of application of pharmaceutical composition, described pharmaceutical composition makes decoction, pill, powder, unguentum, sublimed preparation, capsule or granule.Although using decoction, granule as embodiment in embodiment below, those skilled in the art can be expected that described pharmaceutical composition is made, pill, powder, unguentum, sublimed preparation, capsule etc., same therapeutic effect can be played.

Wherein, the pharmacological effect of each crude drug is respectively:

Radix Notoginseng: the sweet mildly bitter flavor of Radix Notoginseng property, warm in nature, return liver, stomach through being used as medicine with root, root stock.Rare Chinese medicine, raw with can hemostasia and dissipation blood stasis, reducing swelling and alleviating pain, there is good hemostasia effect, significant hemopoietic function; Can tighten and improve Coronary microcirculation, Radix Notoginseng is used as medicine with a long history, acts on the peculiar treasured be considered as by ancient Chinese medicine doctor in medicine, therefore has the saying of " Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) "." taste is micro-sweet and bitter, quite like the taste of Radix Ginseng for Radix Notoginseng." " all canes flutter trauma, and the dripping person of blood stasis, chew namely stopping of rotten net for catching birds or fish immediately, namely bruise person dissipate.If during by cane, first take one, two money, then the blood not centre of punch, should take it after cane especially, puerperal, clothes were also good.On the whole this medicine temperature, sweet and slightly bitter taste, and sun is bright, the medicine of cloudy blood system of fainting, therefore all disorders of blood can be controlled "." book on Chinese herbal medicine is looked for the truth " is recorded: " Radix Notoginseng, common people only know function hemostasis and pain-relieving.Hardly realize that pain aches work because of blood stasis, because applying loose, blood stops blood.The bitter temperature of Radix Notoginseng abnormal smells from the patient, can in its blood stasis of blood systemization." Radix Notoginseng can increase coronary flow, decreased heart rate, reduces myocardial oxygen consumption, increases myocardium oxygen-resistant ability, improve microcirculation, removes the effect of smooth muscle spasm.

Radix Paeoniae Rubra: bitter, is slightly cold.Return Liver Channel.Function cures mainly clearing away heat and cooling blood, eliminating stasis to stop pain.For maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, injury from falling down, carbuncle skin infection.Radix Paeoniae Rubra can purify the blood a point excess-heat, and dissipating blood stasis blood is detained.This product function is close with Cortex Moutan, therefore normal and Cortex Moutan mutual reinforcement between is for use.But the effect of Cortex Moutan clearing away heat and cooling blood is better, can purify the blood a point excess-heat, can control fever due to yin deficiency again; And Radix Paeoniae Rubra can only be used for blood system excess-heat, be good at promoting blood circulation to remove blood stasis.

Semen Platycladi: sweet in the mouth, property is put down.There is tranquilizing by nourishing the heart, hidroschesis, effect of intestine moistening, for fidgets due to deficiency insomnia, severe palpitation, night sweat due to yin deficiency, dryness of the intestine constipation.

Fructus Forsythiae: bitter in the mouth, cold nature.There is heat-clearing and toxic substances removing, effect of dispersing swelling and dissipating binds, for carbuncle, anemopyretic cold.Warmly to join the army, high hot excessive thirst.

The Radix Astragali: sweet in the mouth, slightly warm in nature.Have benefiting QI for strengthening the superficies, arresting sweating takes off admittedly, effect of inducing diuresis to remove edema, weak for the deficiency of vital energy, sinking of QI of middle-JIAO, blood deficiency and yellow complexion.

Herba Coriandri, pungent, warm, attach to the lung and stomach meridians, diaphoresis rash, removing stagnancy of indigested food and making QI downward, be amusing and in.

Ramulus Salicis Babylonicae, bitter, cold, return bright, the JUE YIN meridian of foot sun, dispel the wind, diuresis, pain relieving, detumescence.Dispelling the wind and dampness pathogens arthralgia pain.

Ramulus Populi Davidianae, bitter, cold, return spleen channel, promoting QI to circulate and dispersing the agglomeration of the pathogens.

Ramulus Persicae, bitter, flat, GUIXIN, liver, large intestine channel, diuretic, blood circulation promoting and blood stasis dispelling, dredging collateral, controls cardiac and abdominal pain.

Rhizoma Phragmitis, sweet, cold, attach to the lung and stomach meridians, clearing away heat and promoting production of body fluid, except vexed.

Rhizoma Atractylodis: property is pungent, bitter in the mouth, temperature.Return spleen, stomach, Liver Channel.Function cures mainly drying damp and strengthening spleen, expelling wind and cold, improving eyesight.For distension and fullness in the abdomen, edema of having loose bowels, beriberi flaccidity of feet with lamenness, rheumatic arthralgia, anemofrigid cold, nyctalopia.Show the impact of cardiovascular system, Rhizoma Atractylodis have slight inhibitory action to toad heart, have slight dilating effect to Bufo siccus hind leg blood vessel.The low dose of intravenous injection of Rhizoma Atractylodis extractum, rabbits blood pressure can be made slightly to increase, and heavy dose then makes blood pressure drops.The pharmacological action that effect that Rhizoma Atractylodis are drying damp and strengthening spleen is correlated with is for adjusting gastrointestinal motility function, antiulcer, protecting the liver.Antibacterial etc.The volatile oil that Rhizoma Atractylodis principle active component is is representative with sagittol and hinesol.Rhizoma Atractylodis are on the impact of blood glucose, and anti-hypoxia, CNS inhibition, antitumor, promotion skeleton calcification and on effects such as the impacts of cardiovascular system are then the modern study progress of its pharmacological action.

Medulla Junci: sweet in the mouth, light, cold nature.There is clearing away heart-fire, effect of diuresis, for vexed insomnia.The puckery pain of oliguria, aphtha of the mouth and tongue.

Flos Carthami: acrid in the mouth, warm in nature.Have promoting blood circulation to restore menstrual flow, effect of eliminating stasis to stop pain, for amenorrhea, lochia, skin infection swells and ache.

Rhizoma Chuanxiong: enter liver, spleen, three burnt three warps.Function cures mainly activating QI to alleviate the depression, and method wind-dryness is wet, promoting blood circulation and stopping pain.Controlling air-cooled headache revolves dizzy, and hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.For menoxenia, amenorrhea dysmenorrhea, abdominal mass is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia." detailed outline " carries: " dampness, antidiarrheal dysentery, activating QI to alleviate the depression." ligustrazine removes vascular smooth muscle (aortic article) spasm (epinephrine, potassium chloride cause).Can also coronary vasodilator be expanded, increase coronary flow.The myocardial ischemia-anoxemia that antagonism pituitrin causes.Alleviate the myocardial infarction lesion degree that ligation arteria coronaria causes.

Rhizoma Curcumae: pungent, bitter, temperature.Return liver, spleen channel.Removing blood stasis promoting the circulation of QI to relieve pain: this product effect is similar to Rhizoma Sparganii, but warm concerted effort is comparatively large, can treat amenorrhea due to stagnation of blood stomachache, abdominal mass, gather.Long-pending eliminating stagnation: this product energy circulation of qi promoting removing food stagnancy pain relieving, for eating accumulation, breast abdominal distention is vexed has a pain.Removing blood stasis, women's amenorrhea, or the lump in the abdomen addiction block of phlegm-damp congestion condensation.Promoting the circulation of QI to relieve pain: be suitable for drinking and eating irregularly, the card of gastral cavity abdomen overflow pain.Suitable compatibility, deficient syndrome, the case of a physically strong patient running a high fever.

Radix Ophiopogonis: sweet in the mouth, micro-hardship, cold nature.Have YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire, and for dryness of the lung dry cough, cough due to consumptive disease, vexed insomnia, interior-heat is quenched one's thirst.

Radix Curcumae: acrid in the mouth, hardship, cold in nature.There is regulating qi to disperse stagnation, heart fire-clearing upset-relieving, effect of promoting the function of the gallbladder to alleviate jaundice, for amenorrhea dysmenorrhea, chest and abdomen swelling and pain.

Bulbus Allii Macrostemonis: cure mainly the thorough back of the body of obstruction of qi in the chest and cardialgia; Breast gastral cavity painful abdominal mass is vexed; Cough with asthma abundant expectoration; Epigastric pain; Heavy after letting out dysentery; Leucorrhea; Furuncle carbuncle.Extrasomatic rabbit heart perfusion experiment result shows that Bulbus Allii Macrostemonis can make coronary flow reduce (but no significant difference), then there is the rapid decay of heart contracting power, there is the feature being difficult to recover, therefore this coronary flow reduces like non-caused by heart contracting power suppresses, and may be the result that medicine direct effect arteria coronaria makes it to shrink; But experimental result is not quite identical, in 16 experiments, acts on not obvious or make coronary flow enhancer have 7 times on the contrary.In addition, Bulbus Allii Macrostemonis has inhibitory action to heart rate, but degree little (being less than 10%)." book on Chinese herbal medicine is looked for the truth ": Chinese onion, acrid in the mouth then falls apart, loose then can make cold stagnantly vertically to disappear upper; Bitter in the mouth then falls, and falls, and can make lower stagnant making of trembling with fear; Temperature then falls apart, loose then can make vertical to remove invasion by pathogenic cold is stagnant; Body is sliding then to be led to, and general rule can make chronic cold stagnant vertical solution of a specified duration.Be can remove with dysentery, blood stasis can fall apart, and dyspnea with rapid respiration can stop, and edema can be applied, and thoracic obstruction twinge can be healed, and tire produces and can control, and soup fire and attacked by pestiferous factors soldier extremely can rescue, and real ventilation, sliding key, supporing yang good merchantable brand are also.Function has class in fragrant-flowered garlic, but fragrant-flowered garlic then enters blood gas and kidney-replenishing, this then specially logical cold stagnant and double sliding key be different ear.

Ramulus Cinnamomi acrid, sweet, warm.GUIXIN, lung, urinary bladder channel.Expelling cold and relieving exterior syndrome; Promoting the flow of QI-blood by warming the meridian; Activating YANG and prormoting functioning of QI.Diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.1. antibacterial action: Ramulus Cinnamomi ethanol extract can suppress escherichia coli, bacillus subtilis and staphylococcus aureus in vitro, valid density is 25mg/ml or following; Also inhibitory action (flat board dig a hole method) 2. antivirus action is had: with the primary adhesion tissue culture of human embryo kidney (HEK), Ramulus Cinnamomi decoct (1: 20) has inhibitory action to the section 68-l strain of A type capital, influenza Asia and Orphan virus (ECHO11) to Staphylococcus albus, dysentery bacterium, Typhoid and paratyphoid first bacillus, streptococcus pneumoniae, aerobacteria, Bacillus proteus, anthrax bacillus, Salmonella enteritidis, vibrio cholera etc.On Embryo Gallus domesticus, infected by influenza has inhibitory action, better with 70% alcohol preserved material effect.

Radix Pseudostellariae: sweet in the mouth, micro-hardship, property is put down.There is replenishing QI to invigorate the spleen, effect of promoting the production of body fluid for nourishing the lung, tired for insufficiency of the spleen body, inappetence is weak after being ill.

Fructus Trichosanthis: sweet in the mouth, micro-hardship, cold in nature.There is clearing away heat and eliminating phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens, moisturize effect of laxation, for cough due to lung-heat, obstruction of qi in the chest and cardialgia, lung abscess.

Herba Lophatheri: sweet in the mouth, light, cold in nature.Have clearing heat and relieving fidgetness, effect of diuresis, for calentura excessive thirst, hot urination drenches pain, aphtha of the mouth and tongue.

Rhizoma Arisaematis: bitter in the mouth, pungent, warm in nature.Have drying dampness to eliminate phlegm, expelling wind and relieving convulsion, effect of mass dissipating and swelling eliminating, for pertinacious phlegm cough, paralysis is dizzy, hemiplegia.

Radix Glycyrrhizae Preparata: sweet in the mouth, property are flat.Have spleen reinforcing stomach function regulating, effect of Yiqi and vein recovery, for weakness of the spleen and stomach, tired state is weak, severe palpitation, irregularly intermittent and regularly intermittent pulse.

Cortex Albiziae: sweet in the mouth, property is put down.Have resolving stagnation for tranquilization, effect of promoting blood circulation and detumescence, for irritability, resolving depression is had a sleepless night, and lung abscess skin ulcer swells, and falls and flutters the pain of injury.

Fructus Schisandrae Chinensis: sour in the mouth, sweet, warm in nature.Have convergence astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, effect of kidney calming, coughs for chronic cough void, spontaneous perspiration, night sweat.

Radix Salviae Miltiorrhizae: Radix Salviae Miltiorrhizae is bitter, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen lumps, and skin infection swells and ache, and tumbling down is grieved, menoxenia, amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect.Lid Radix Salviae Miltiorrhizae can break stagnated blood, and mend fresh blood, peaceful tire, fall stillborn fetus, only metrorrhagia dysentery, regulating menstruation arteries and veins.Its chemical composition of Radix Salviae Miltiorrhizae is mainly divided into 2 classes: one is fat-soluble TANSHINONES, and one is water solublity danshensu etc.No matter be clinical or the most scholar of experimentation has affirmed that Radix Salviae Miltiorrhizae has coronary artery dilator, improve myocardium anti-anoxia ability, expansion peripheral blood vessel, improve microcirculation, regulate reparation and the regeneration of tissue, anticoagulant activates fibrinolytic, enhancing immunity, effect such as antibacterial grade.Especially it when core function badness, can improve myocardial contraction when not affecting oxygen consumption, decreased heart rate, and cardiac function is obviously improved, and blood flow can be made to accelerate, and capillary bed is open to be increased.

RHIIZOMA CIMICIFUGAE FOETIDAE: have calentura aphtha, high fever is had a headache, effect of mind agitation.

Radix Cynanchi Atrati: there is clearing away heat and cooling blood, inducing diuresis for treating stranguria syndrome, detoxification sore treatment.For pathogenic warmth wound battalion heating, fever due to yin deficiency, hectic fever due to YIN-deficiency consumptive fever, puerperal fever due to deficiency of blood, pyretic stranguria, stranguria with blood, effect of swollen ulcer drug.

Herba Cistanches: there is kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation.For sexual impotence, infertile, soreness of the waist and knees, muscles and bones is unable, effect of dryness of the intestine constipation.

Caulis Spatholobi: bitter in the mouth, micro-sweet, warm in nature; Return liver, the heart, kidney channel.Relaxing muscles and tendons to promote blood circulation, nourishing blood for regulating menstruation.Cure mainly rheumatic arthralgia, numb hand and foot, quadriplegia, menoxenia, blockage of menstruation, dysmenorrhea, amenorrhea, leukopenia.

Herba Portulacae: cold in nature, sweet in the mouth, acid; Enter the heart, liver, spleen, large intestine channel.Removing dampness is antipruritic, heat-clearing and toxic substances removing, and diuretic dries, loose blood detumescence, dust-collection sterilization, anti-inflammatory analgetic.Modern medicine study confirms, Herba Portulacae has stronger inhibitory action to dysentery bacterium, Bacillus typhi and escherichia coli, can be used for the auxiliary treatment of various inflammation, have the title of " natural antibiotics ".

Semen Celosiae: bitter in the mouth, cold in nature; Return Liver Channel.To dispel people's heat, clearing away liver-fire, improving acuity of vision and removing nebula.Main conjunctival congestion and swelling pain, nebula of looking unfamiliar film, blurring of vision, hypertension, epistaxis, skin wind heat pruritus, skin ulcer tinea." property of medicine opinion " carries: " the dirty pyretic toxicity dotting punch for the treatment of the liver, red barrier, optic atrohic blindness, nebula are swollen.Main malignant boil scabies scabies, controls the inferior portion's worm dew skin ulcer.”

Selected by pharmaceutical composition of the present invention, medical material compatibility is suitable; meet Chinese medicine and modern medicine research theory; and adopt modern advanced medical pharmaceutical technology to make; there is Yiqiyangyuan, strengthening vital QI to eliminate pathogenic factors, nourish heart the effect of promoting blood circulation; can two-ways regulation immunologic function; the various myocarditis symptom of effective control; protection cardiac muscle; promote that myocardial function recovers, evident in efficacy, not only long action time; short treating period; instant effect, safe without toxic side effect, and have prevent the state of an illness from occurring, delay and the effect of prevention of recurrence.

Detailed description of the invention

For making the object of the embodiment of the present invention, technical scheme and advantage clearly, below in conjunction with embodiment, technical scheme of the present invention is clearly and completely described.Obviously, described embodiment is a part of the present invention, instead of whole embodiments.Based on described embodiments of the invention, the every other embodiment that those of ordinary skill in the art obtain under without the need to the prerequisite of creative work, all belongs to the scope of protection of the invention.

Embodiment 1:

One of the present invention treats myocarditic pharmaceutical composition, get following traditional Chinese medicine raw medicine: Radix Notoginseng 13 grams, Radix Paeoniae Rubra 10 grams, Semen Platycladi 3 grams, Fructus Forsythiae 7 grams, the Radix Astragali 19 grams, Herba Coriandri 25 grams, Ramulus Salicis Babylonicae 36 grams, Ramulus Populi Davidianae 18 grams, Ramulus Persicae 30 grams, Rhizoma Phragmitis 45 grams, Rhizoma Atractylodis 16 grams, Medulla Junci 2 grams, 7 grams, Flos Carthami, Rhizoma Chuanxiong 35 grams, Rhizoma Curcumae 30 grams, Radix Ophiopogonis 16 grams, Radix Curcumae 13 grams, Bulbus Allii Macrostemonis 25 grams, Ramulus Cinnamomi 5 grams, Radix Pseudostellariae 15 grams, Fructus Trichosanthis 30 grams, Herba Lophatheri 16 grams, Rhizoma Arisaematis 23 grams, Radix Glycyrrhizae Preparata 3 grams, Cortex Albiziae 9 grams, Fructus Schisandrae Chinensis 7 grams, Radix Salviae Miltiorrhizae 12 grams, RHIIZOMA CIMICIFUGAE FOETIDAE 15 grams, Radix Cynanchi Atrati 10 grams, Herba Cistanches 15 grams, Caulis Spatholobi 17 grams, Herba Portulacae 15 grams, Semen Celosiae 8 grams.

The preparation method of the myocarditic pharmaceutical composition of described treatment is specially following steps:

(1) extract each raw material of Chinese medicine medicine by said ratio, be then jointly carefully ground into medicamental pulverata, for subsequent use;

Clinical data:

Case: in February, 2009, Lu, male, 35 years old, spring, flu caused parotitis, and cardiopalmus, uncomfortable in chest, pareordia is uncomfortable or pain (activity postemphasis), irritated, dizzy, weak, dreaminess, complexion pastiness, out of breath, edema, irregularly intermittent and regularly intermittent pulse, Electrocardioscopy all occurs that ST-T changes, and occurs I ~ II Aminophyline.Adopt the medicinal liquid that above-mentioned formula and preparation method are made, daily three times, within 7 days, take a turn for the better, after 32 days, symptom is clearly better, and after treating 3 months, electrocardiogram S-T section often changes correction, and cardiac ultrasonic shows that Left ventricular systolic function is normal, continue to take consolidation in 50 days, do not recur so far after drug withdrawal.

Embodiment 2:

One of the present invention treats myocarditic pharmaceutical composition, get following traditional Chinese medicine raw medicine: Radix Notoginseng 11 grams, Radix Paeoniae Rubra 12 grams, Semen Platycladi 3.5 grams, Fructus Forsythiae 8 grams, the Radix Astragali 17 grams, Herba Coriandri 22 grams, Ramulus Salicis Babylonicae 32 grams, Ramulus Populi Davidianae 16 grams, Ramulus Persicae 30 grams, Rhizoma Phragmitis 40 grams, Rhizoma Atractylodis 12 grams, Medulla Junci 3 grams, 5 grams, Flos Carthami, Rhizoma Chuanxiong 35 grams, Rhizoma Curcumae 33 grams, Radix Ophiopogonis 16 grams, Radix Curcumae 13 grams, Bulbus Allii Macrostemonis 20 grams, Ramulus Cinnamomi 5 grams, Radix Pseudostellariae 13 grams, Fructus Trichosanthis 31 grams, Herba Lophatheri 16 grams, Rhizoma Arisaematis 23 grams, Radix Glycyrrhizae Preparata 3 grams, Cortex Albiziae 3 grams, Fructus Schisandrae Chinensis 5 grams, Radix Salviae Miltiorrhizae 10 grams, RHIIZOMA CIMICIFUGAE FOETIDAE 15 grams, Radix Cynanchi Atrati 10 grams, Herba Cistanches 12 grams, Caulis Spatholobi 41 grams, Herba Portulacae 40 grams, Semen Celosiae 32 grams.

(2) medicamental pulverata getting grinding in step (1) is positioned in marmite and adds water, the water yield is 5 times of medicamental pulverata weight, then with big fire by after water boil 6-7min, change little fire to decoct, stir medicamental pulverata when decocting, stirring number of times is 2-3 time, and decocting time is 30-45min, rear elimination medicinal residues are decocted, taking liquid.

Clinical data:

Case: in April, 2012, Zhao, female, 36 years old, hyperpyrexia, giddy, weak, dreaminess, complexion pastiness, out of breath, edema, irregularly intermittent and regularly intermittent pulse, auscultation had arrhythmia, audible and systolic murmur.Adopt the medicinal liquid that above-mentioned formula and preparation method are made, within 12 days, improve, after 23 days, symptom is clearly better, daily three times, after treating 3 months, electrocardiogram S-T section often changes correction, cardiac ultrasonic shows that Left ventricular systolic function is normal, continues to take consolidations in 30 days, does not recur so far to follow up a case by regular visits to that so far there are no recurs after drug withdrawal.

Embodiment 3:

One of the present invention treats myocarditic pharmaceutical composition, get following traditional Chinese medicine raw medicine: Radix Notoginseng 9 grams, Radix Paeoniae Rubra 10 grams, Semen Platycladi 4.5 grams, Fructus Forsythiae 8.5 grams, the Radix Astragali 15 grams, Herba Coriandri 20 grams, Ramulus Salicis Babylonicae 28 grams, Ramulus Populi Davidianae 11 grams, Ramulus Persicae 30 grams, Rhizoma Phragmitis 40 grams, Rhizoma Atractylodis 11 grams, Medulla Junci 3.5 grams, 5.5 grams, Flos Carthami, Rhizoma Chuanxiong 35 grams, Rhizoma Curcumae 35 grams, Radix Ophiopogonis 12 grams, Radix Curcumae 11 grams, Bulbus Allii Macrostemonis 20 grams, Ramulus Cinnamomi 5 grams, Radix Pseudostellariae 11 grams, Fructus Trichosanthis 34 grams, Herba Lophatheri 18 grams, Rhizoma Arisaematis 23 grams, Radix Glycyrrhizae Preparata 3.5 grams, Cortex Albiziae 3 grams, Fructus Schisandrae Chinensis 5 grams, Radix Salviae Miltiorrhizae 10 grams, RHIIZOMA CIMICIFUGAE FOETIDAE 15 grams, Radix Cynanchi Atrati 10 grams, Herba Cistanches 12 grams, Caulis Spatholobi 25 grams, Herba Portulacae 25 grams, Semen Celosiae 28 grams.

(2) medicamental pulverata getting grinding in step (1) is positioned in marmite and adds water, the water yield is 5 times of medicamental pulverata weight, then with big fire by after water boil 4min, change little fire to decoct, stir medicamental pulverata when decocting, stirring number of times is 2-3 time, and decocting time is 30-45min, rear elimination medicinal residues are decocted, taking liquid.

Clinical data:

Case: in April, 2012, money, man, 44 years old, because of influenza hyperpyrexia, cardiopalmus, uncomfortable in chest, pareordia is uncomfortable or pain (activity postemphasis), irritated, dizzy, weak, " viral myocarditis ".Sensation of oppression over the chest with shortness of breath, thirsty weak, pale tongue with white fur, deep-thready pulse.The medicinal liquid that the above-mentioned formula of Fang Caiyong and preparation method are made, through the treatment of month, the state of an illness was stablized with becoming; but have slight cardiac dilatation, cardiac kinetic energy go down, arrhythmia or ECG Change; through the treatment of 6 months, patient fully recovered, and does not leave over any Sx.

Embodiment 4:

One of the present invention treats myocarditic pharmaceutical composition, get following traditional Chinese medicine raw medicine: Radix Notoginseng 15 grams, Radix Paeoniae Rubra 8 grams, Semen Platycladi 4 grams, Fructus Forsythiae 9 grams, the Radix Astragali 19 grams, Herba Coriandri 25 grams, Ramulus Salicis Babylonicae 30 grams, Ramulus Populi Davidianae 10 grams, Ramulus Persicae 20 grams, Rhizoma Phragmitis 40 grams, Rhizoma Atractylodis 10 grams, Medulla Junci 3 grams, 6 grams, Flos Carthami, Rhizoma Chuanxiong 35 grams, Rhizoma Curcumae 30 grams, Radix Ophiopogonis 11 grams, Radix Curcumae 13 grams, Bulbus Allii Macrostemonis 20 grams, Ramulus Cinnamomi 5 grams, Radix Pseudostellariae 15 grams, Fructus Trichosanthis 30 grams, Herba Lophatheri 12 grams, Rhizoma Arisaematis 20 grams, Radix Glycyrrhizae Preparata 3 grams, Cortex Albiziae 8 grams, Fructus Schisandrae Chinensis 5 grams, Radix Salviae Miltiorrhizae 10 grams, RHIIZOMA CIMICIFUGAE FOETIDAE 15 grams, Radix Cynanchi Atrati 12 grams, Herba Cistanches 10 grams, Caulis Spatholobi 29 grams, Herba Portulacae 35 grams, Semen Celosiae 30 grams.

The preparation method of aforementioned pharmaceutical compositions, step is:

(1) extract each raw material of Chinese medicine medicine by said ratio and decoct with water 2 times, 2.5 hours first times, second time 1.5 hours, filtrate merging decocts 1 hour again, leaves standstill 30 hours, again filters, and filter, it is 1.05 that filtrate is concentrated into relative density;

(2) step (1) gained filtrate is added ethanol, ethanol consumption is 1.5 times of filtrate quality, abundant mix homogeneously, leaves standstill cold preservation 25 hours, and filter, after filtrate recycling ethanol, then continuing to be concentrated into thick paste, is 1.40 to relative density;

Clinical data:

Case: grandson, man, 51 years old, symptom: patient has dilated myocarditis frequent sensation of oppression over the chest with shortness of breath for many years, and cardiopalmus is weak, dyspnea, abdominal distention, all can cause these symptoms when excited or some fatigue once in a while.Sick age: 4.5 years.Examine the time: on October 01st, 2013; Take the granule that Chinese medicine composition of the present invention is made, get 10 grams at every turn and brew with boiled water, one day twice, sooner or later within 1 hour after meal, take every day.Take 15 days, sensation of oppression over the chest with shortness of breath remission, take 20 days, sensation of oppression over the chest with shortness of breath symptom disappears completely, and dyspnea takes a turn for the better; Take 1 month, breathe normal, abdominal distention disappears; Take 1 first quarter moon, cardiopalmus remission, weak transference cure; Take 2 months, cardiopalmus transference cure, every ill symptoms disappears completely, takes again Chinese medicine composition granule consolidate curative effect of the present invention 10 days after recovering, and drug withdrawal is so far without recurrence.

Embodiment 5:

One of the present invention treats myocarditic pharmaceutical composition, get following traditional Chinese medicine raw medicine: Radix Notoginseng 11 grams, Radix Paeoniae Rubra 9 grams, Semen Platycladi 5 grams, Fructus Forsythiae 10 grams, the Radix Astragali 18 grams, Herba Coriandri 20 grams, Ramulus Salicis Babylonicae 32 grams, Ramulus Populi Davidianae 12 grams, Ramulus Persicae 21 grams, Rhizoma Phragmitis 40 grams, Rhizoma Atractylodis 13 grams, Medulla Junci 3.5 grams, 6 grams, Flos Carthami, Rhizoma Chuanxiong 35 grams, Rhizoma Curcumae 30 grams, Radix Ophiopogonis 11 grams, Radix Curcumae 13 grams, Bulbus Allii Macrostemonis 22 grams, Ramulus Cinnamomi 6 grams, Radix Pseudostellariae 12 grams, Fructus Trichosanthis 30 grams, Herba Lophatheri 12 grams, Rhizoma Arisaematis 20 grams, Radix Glycyrrhizae Preparata 3 grams, Cortex Albiziae 9 grams, Fructus Schisandrae Chinensis 4 grams, Radix Salviae Miltiorrhizae 11 grams, RHIIZOMA CIMICIFUGAE FOETIDAE 11 grams, Radix Cynanchi Atrati 10 grams, Herba Cistanches 10 grams, Caulis Spatholobi 40 grams, Herba Portulacae 20 grams, Semen Celosiae 24 grams.

The preparation method of aforementioned pharmaceutical compositions, step is:

(1) extract each raw material of Chinese medicine medicine by said ratio and decoct with water 2 times, 2.0 hours first times, second time 1.5 hours, filtrate merging decocts 1 hour again, leaves standstill 30 hours, again filters, and filter, it is 1.05 that filtrate is concentrated into relative density;

(2) step (1) gained filtrate is added ethanol, ethanol consumption is 1.5 times of filtrate quality, abundant mix homogeneously, leaves standstill cold preservation 30 hours, and filter, after filtrate recycling ethanol, then continuing to be concentrated into thick paste, is 1.40 to relative density;

Clinical data:

Case: Lee, man, 43 years old, symptom: patient's last spring is because occurring palpitation and short breath after flu, malaise, the symptom of easy perspiration, and movable rear exacerbation of symptoms, going to hospital is after diagnosing viral myocarditis, hospitalization takes a turn for the better, but nearly one week recurs because of fatigue, symptom is obviously serious than before, have also appeared uncomfortable in chest.Sick age: 2 years half.Examine the time: on February 21st, 2013; Take the granule that Chinese medicine composition of the present invention is made, get 10 grams at every turn and brew with boiled water, one day twice, sooner or later within 1 hour after meal, take every day.Take 10 days, symptom uncomfortable in chest alleviates; Take 20 days, symptom uncomfortable in chest disappears completely, perspiration remission; Take 1 month, perspiration transference cure, palpitation and short breath symptom is obviously improved; Take 1 first quarter moon, palpitation and short breath transference cure, recovers.Have no adverse reaction during taking Chinese medicine composition granule of the present invention, drug withdrawal is so far without recurrence.

Embodiment 6

One treats myocarditic pharmaceutical composition, get following traditional Chinese medicine raw medicine: Radix Notoginseng 10 grams, Radix Paeoniae Rubra 6 grams, Semen Platycladi 2 grams, Fructus Forsythiae 13 grams, the Radix Astragali 13 grams, Herba Coriandri 23 grams, Ramulus Salicis Babylonicae 31 grams, Ramulus Populi Davidianae 11 grams, Ramulus Persicae 17 grams, Rhizoma Phragmitis 34 grams, Rhizoma Atractylodis 15 grams, Medulla Junci 5 grams, 8 grams, Flos Carthami, Rhizoma Chuanxiong 30 grams, Rhizoma Curcumae 32 grams, Radix Ophiopogonis 15 grams, Radix Curcumae 18 grams, Bulbus Allii Macrostemonis 22 grams, Ramulus Cinnamomi 5 grams, Radix Pseudostellariae 10 grams, Fructus Trichosanthis 26 grams, Herba Lophatheri 15 grams, Rhizoma Arisaematis 25 grams, Radix Glycyrrhizae Preparata 4 grams, Cortex Albiziae 8 grams, Fructus Schisandrae Chinensis 5 grams, Radix Salviae Miltiorrhizae 12 grams, RHIIZOMA CIMICIFUGAE FOETIDAE 15 grams, Radix Cynanchi Atrati 16 grams, Herba Cistanches 15 grams, Caulis Spatholobi 23 grams, Herba Portulacae 35.5 grams, Semen Celosiae 12 grams.

This pharmaceutical composition is prepared respectively according to the preparation method of granule in the preparation method of embodiment 1 herb liquid and embodiment 4.

Clinical data:

In order to verify the effect of Chinese medicine composition of the present invention, in March, 2014-July, under the guidance of the several department of cardiac surgery expert of Beijing University of Chinese Medicine, we have randomly drawed 300 patients and have carried out the experiment of said medicine, be equally divided into three groups, often organize 100 people, experimental group 1 (taking medicinal liquid), experimental group 2 (taking granule) and matched group, experimental group 1,2 uses embodiment 6 gained pharmaceutical composition, and matched group is taken other and treated myocarditic Chinese medicine.

Inclusion criteria: through being diagnosed as patients with myocarditis, disease 2-3 in age, has myocarditis clinical symptoms one or more.

Curative effect situation criterion (contrasting with the data taken 3 months): 1, cure.Drug administration 3 months, malaise symptoms disappears completely; 2, effective.Drug administration 3 months, malaise symptoms alleviates or partial disappearance; 3, invalid.Drug administration 3 months, malaise symptoms is unchanged.

We have carried out accurate statistics and mathematical analysis to experimental data.Specific experiment result is as following table:

Table 1: three groups of Clinical efficacy comparisons [example]

Group	Case load	Cure	Effectively	Invalid	Total effective rate
						Matched group	100	11	41	26	52％

Experimental group 1 (taking medicinal liquid)	100	94	3	3	97％
						Experimental group 2 (taking granule)	100	95	3	2	98％

Result: through Clinical efficacy comparison, matched group total effective rate is 52%; Experimental group 1,2 total effective rate is respectively 97%, 98%, and two groups of total effective rates compare and show that experimental group curative effect is better than matched group.

In sum, Chinese medicine composition of the present invention effective percentage compared with other treats myocarditic medicine is high, total effective rate is more than 97%, higher than matched group effective percentage by 45%, successful is better than matched group, the Chinese medicine composition of this invention is cheap, ordinary people life-time service, also can not increase health and pecuniary burden.A routine side effect profile is there is not in clinical experiment, safety is far above the myocarditic similar drugs for the treatment of, and it is evident in efficacy, use Chinese medicine composition of the present invention can rapid recovery the disease cardiopalmus, the vertigo symptoms that bring, due to illness debilitant health can also be nursed one's health, belonging to the prescription of giving consideration to both the incidental and fundamental, is treat the ideal safe Chinese medicine composition of myocarditis at present.

Last it is noted that above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the scope of various embodiments of the present invention technical scheme.

Claims

1. the myocarditic pharmaceutical composition for the treatment of, it is characterized in that, raw material composition and the parts by weight of making described pharmaceutical composition are: Radix Notoginseng 7-13 part, Radix Paeoniae Rubra 6-12 part, Semen Platycladi 2-5 part, Fructus Forsythiae 7-13 part, Radix Astragali 13-19 part, Herba Coriandri 20-25 part, Ramulus Salicis Babylonicae 28-36 part, Ramulus Populi Davidianae 10-18 part, Ramulus Persicae 17-30 part, Rhizoma Phragmitis 34-45 part, Rhizoma Atractylodis 10-16 part, Medulla Junci 2-5 part, Flos Carthami 5-8 part, Rhizoma Chuanxiong 30-35 part, Rhizoma Curcumae 30-35 part, Radix Ophiopogonis 11-16 part, Radix Curcumae 11-18 part, Bulbus Allii Macrostemonis 20-25 part, Ramulus Cinnamomi 5-6 part, Radix Pseudostellariae 10-15 part, Fructus Trichosanthis 26-34 part, Herba Lophatheri 12-18 part, Rhizoma Arisaematis 20-25 part, Radix Glycyrrhizae Preparata 3-4 part, Cortex Albiziae 3-9 part, Fructus Schisandrae Chinensis 4-7 part, Radix Salviae Miltiorrhizae 10-12 part, RHIIZOMA CIMICIFUGAE FOETIDAE 11-15 part, Radix Cynanchi Atrati 10-16 part, Herba Cistanches 10-15 part, Caulis Spatholobi 17-44 part, Herba Portulacae 15-40 part, Semen Celosiae 8-32 part.

2. the myocarditic pharmaceutical composition for the treatment of according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described pharmaceutical composition are: Radix Notoginseng 13 parts, Radix Paeoniae Rubra 10 parts, Semen Platycladi 3 parts, Fructus Forsythiae 7 parts, the Radix Astragali 19 parts, Herba Coriandri 25 parts, Ramulus Salicis Babylonicae 36 parts, Ramulus Populi Davidianae 18 parts, Ramulus Persicae 30 parts, Rhizoma Phragmitis 45 parts, Rhizoma Atractylodis 16 parts, Medulla Junci 2 parts, 7 parts, Flos Carthami, Rhizoma Chuanxiong 35 parts, Rhizoma Curcumae 30 parts, Radix Ophiopogonis 16 parts, Radix Curcumae 13 parts, Bulbus Allii Macrostemonis 25 parts, Ramulus Cinnamomi 5 parts, Radix Pseudostellariae 15 parts, Fructus Trichosanthis 30 parts, Herba Lophatheri 16 parts, Rhizoma Arisaematis 23 parts, Radix Glycyrrhizae Preparata 3 parts, Cortex Albiziae 9 parts, Fructus Schisandrae Chinensis 7 parts, Radix Salviae Miltiorrhizae 12 parts, RHIIZOMA CIMICIFUGAE FOETIDAE 15 parts, Radix Cynanchi Atrati 10 parts, Herba Cistanches 15 parts, Caulis Spatholobi 17 parts, Herba Portulacae 15 parts, Semen Celosiae 8 parts.

3. the myocarditic pharmaceutical composition for the treatment of according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described pharmaceutical composition are: Radix Notoginseng 11 parts, Radix Paeoniae Rubra 12 parts, Semen Platycladi 3.5 parts, Fructus Forsythiae 8 parts, the Radix Astragali 17 parts, Herba Coriandri 22 parts, Ramulus Salicis Babylonicae 32 parts, Ramulus Populi Davidianae 16 parts, Ramulus Persicae 30 parts, Rhizoma Phragmitis 40 parts, Rhizoma Atractylodis 12 parts, Medulla Junci 3 parts, 5 parts, Flos Carthami, Rhizoma Chuanxiong 35 parts, Rhizoma Curcumae 33 parts, Radix Ophiopogonis 16 parts, Radix Curcumae 13 parts, Bulbus Allii Macrostemonis 20 parts, Ramulus Cinnamomi 5 parts, Radix Pseudostellariae 13 parts, Fructus Trichosanthis 31 parts, Herba Lophatheri 16 parts, Rhizoma Arisaematis 23 parts, Radix Glycyrrhizae Preparata 3 parts, Cortex Albiziae 3 parts, Fructus Schisandrae Chinensis 5 parts, Radix Salviae Miltiorrhizae 10 parts, RHIIZOMA CIMICIFUGAE FOETIDAE 15 parts, Radix Cynanchi Atrati 10 parts, Herba Cistanches 12 parts, Caulis Spatholobi 41 parts, Herba Portulacae 40 parts, Semen Celosiae 32 parts.

4. the myocarditic pharmaceutical composition for the treatment of according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described pharmaceutical composition are: Radix Notoginseng 9 parts, Radix Paeoniae Rubra 10 parts, Semen Platycladi 4.5 parts, Fructus Forsythiae 8.5 parts, the Radix Astragali 15 parts, Herba Coriandri 20 parts, Ramulus Salicis Babylonicae 28 parts, Ramulus Populi Davidianae 11 parts, Ramulus Persicae 30 parts, Rhizoma Phragmitis 40 parts, Rhizoma Atractylodis 11 parts, Medulla Junci 3.5 parts, 5.5 parts, Flos Carthami, Rhizoma Chuanxiong 35 parts, Rhizoma Curcumae 35 parts, Radix Ophiopogonis 12 parts, Radix Curcumae 11 parts, Bulbus Allii Macrostemonis 20 parts, Ramulus Cinnamomi 5 parts, Radix Pseudostellariae 11 parts, Fructus Trichosanthis 34 parts, Herba Lophatheri 18 parts, Rhizoma Arisaematis 23 parts, Radix Glycyrrhizae Preparata 3.5 parts, Cortex Albiziae 3 parts, Fructus Schisandrae Chinensis 5 parts, Radix Salviae Miltiorrhizae 10 parts, RHIIZOMA CIMICIFUGAE FOETIDAE 15 parts, Radix Cynanchi Atrati 10 parts, Herba Cistanches 12 parts, Caulis Spatholobi 25 parts, Herba Portulacae 25 parts, Semen Celosiae 28 parts.

5. the myocarditic pharmaceutical composition for the treatment of according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described pharmaceutical composition are: Radix Notoginseng 15 parts, Radix Paeoniae Rubra 8 parts, Semen Platycladi 4 parts, Fructus Forsythiae 9 parts, the Radix Astragali 19 parts, Herba Coriandri 25 parts, Ramulus Salicis Babylonicae 30 parts, Ramulus Populi Davidianae 10 parts, Ramulus Persicae 20 parts, Rhizoma Phragmitis 40 parts, Rhizoma Atractylodis 10 parts, Medulla Junci 3 parts, 6 parts, Flos Carthami, Rhizoma Chuanxiong 35 parts, Rhizoma Curcumae 30 parts, Radix Ophiopogonis 11 parts, Radix Curcumae 13 parts, Bulbus Allii Macrostemonis 20 parts, Ramulus Cinnamomi 5 parts, Radix Pseudostellariae 15 parts, Fructus Trichosanthis 30 parts, Herba Lophatheri 12 parts, Rhizoma Arisaematis 20 parts, Radix Glycyrrhizae Preparata 3 parts, Cortex Albiziae 8 parts, Fructus Schisandrae Chinensis 5 parts, Radix Salviae Miltiorrhizae 10 parts, RHIIZOMA CIMICIFUGAE FOETIDAE 15 parts, Radix Cynanchi Atrati 12 parts, Herba Cistanches 10 parts, Caulis Spatholobi 29 parts, Herba Portulacae 35 parts, Semen Celosiae 30 parts.

6. the myocarditic pharmaceutical composition for the treatment of according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described pharmaceutical composition are: Radix Notoginseng 11 parts, Radix Paeoniae Rubra 9 parts, Semen Platycladi 5 parts, Fructus Forsythiae 10 parts, the Radix Astragali 18 parts, Herba Coriandri 20 parts, Ramulus Salicis Babylonicae 32 parts, Ramulus Populi Davidianae 12 parts, Ramulus Persicae 21 parts, Rhizoma Phragmitis 40 parts, Rhizoma Atractylodis 13 parts, Medulla Junci 3.5 parts, 6 parts, Flos Carthami, Rhizoma Chuanxiong 35 parts, Rhizoma Curcumae 30 parts, Radix Ophiopogonis 11 parts, Radix Curcumae 13 parts, Bulbus Allii Macrostemonis 22 parts, Ramulus Cinnamomi 6 parts, Radix Pseudostellariae 12 parts, Fructus Trichosanthis 30 parts, Herba Lophatheri 12 parts, Rhizoma Arisaematis 20 parts, Radix Glycyrrhizae Preparata 3 parts, Cortex Albiziae 9 parts, Fructus Schisandrae Chinensis 4 parts, Radix Salviae Miltiorrhizae 11 parts, RHIIZOMA CIMICIFUGAE FOETIDAE 11 parts, Radix Cynanchi Atrati 10 parts, Herba Cistanches 10 parts, Caulis Spatholobi 40 parts, Herba Portulacae 20 parts, Semen Celosiae 24 parts.

7. the myocarditic pharmaceutical composition for the treatment of according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described pharmaceutical composition are: Radix Notoginseng 10 parts, Radix Paeoniae Rubra 6 parts, Semen Platycladi 2 parts, Fructus Forsythiae 13 parts, the Radix Astragali 13 parts, Herba Coriandri 23 parts, Ramulus Salicis Babylonicae 31 parts, Ramulus Populi Davidianae 11 parts, Ramulus Persicae 17 parts, Rhizoma Phragmitis 34 parts, Rhizoma Atractylodis 15 parts, Medulla Junci 5 parts, 8 parts, Flos Carthami, Rhizoma Chuanxiong 30 parts, Rhizoma Curcumae 32 parts, Radix Ophiopogonis 15 parts, Radix Curcumae 18 parts, Bulbus Allii Macrostemonis 22 parts, Ramulus Cinnamomi 5 parts, Radix Pseudostellariae 10 parts, Fructus Trichosanthis 26 parts, Herba Lophatheri 15 parts, Rhizoma Arisaematis 25 parts, Radix Glycyrrhizae Preparata 4 parts, Cortex Albiziae 8 parts, Fructus Schisandrae Chinensis 5 parts, Radix Salviae Miltiorrhizae 12 parts, RHIIZOMA CIMICIFUGAE FOETIDAE 15 parts, Radix Cynanchi Atrati 16 parts, Herba Cistanches 15 parts, Caulis Spatholobi 23 parts, Herba Portulacae 35.5 parts, Semen Celosiae 12 parts.

8. treat a preparation method for myocarditic pharmaceutical composition, it is characterized in that, described preparation method is specially following steps:

9. treat a preparation method for myocarditic pharmaceutical composition, it is characterized in that, described preparation method is specially following steps:

10., according to the application of the arbitrary described pharmaceutical composition of claim 1-7, it is characterized in that: described pharmaceutical composition makes decoction, pill, powder, unguentum, sublimed preparation, capsule or granule.