CN104435763A - Medicine for treating oculopathy - Google Patents

Medicine for treating oculopathy Download PDF

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Publication number
CN104435763A
CN104435763A CN201410739461.0A CN201410739461A CN104435763A CN 104435763 A CN104435763 A CN 104435763A CN 201410739461 A CN201410739461 A CN 201410739461A CN 104435763 A CN104435763 A CN 104435763A
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medicine
parts
oculopathy
crude drug
sterilizing
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CN104435763B (en
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朱本宁
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ANLONG COUNTY DONGFANG WUGUANLING PRODUCTS FACTORY
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ANLONG COUNTY DONGFANG WUGUANLING PRODUCTS FACTORY
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/482—Cassia, e.g. golden shower tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7135—Compounds containing heavy metals
    • A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287—Chrysanthemum, e.g. daisy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
    • A61K36/8984—Dendrobium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention discloses a medicine for treating oculopathy. The medicine comprises the following active pharmaceutical ingredients in parts by weight: 12-17 parts of cassia seed, 12-17 parts of stem of noble dendrobium, 10-15 parts of climbing groundsel herb, 8-13 parts of chrysanthemum, 8-13 parts of feather cockscomb seed and 1-3 parts of borneol. The medicine is obtained by weighing the active pharmaceutical ingredients according to the parts by weight, washing, drying and sterilizing, soaking and decocting the active pharmaceutical ingredients, filtering the decoction, cooling the filtrate and re-sterilizing the filtrate. The medicine provided by the invention has the characteristics of quickness in effect taking, good curative effects and no toxic or side effects. The medicine is clinically used by totally 836 patients and the average cure rate is 91.5%. The medicine is convenient and fast to use.

Description

A kind of medicine for the treatment of oculopathy
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of medicine for the treatment of oculopathy.
 
Background technology
Oculopathy is a kind of common clinical symptoms, and occur oculopathy, causes for pathological has a variety of, probably can be divided into infectivity, non-infectious and traumatic, radioactivity these 4 kinds.Certainly the eye symptom also having other disease to cause, as the diseases such as hypertension just can be reflected on the retina of eyes, causes the change of retinal hemorrhage, retina arteriovenous ratio and amphiblestroidly to ooze out.Occur in the mainly iridocyclitis of iris; Occur in lenticular mainly cataract; Occur in Vitrea mainly vitreous opacity; Occur in choroidal disease more rare, but choroid is the blood bank of eyes, the namely tunica vasculose of eyes; Occur in that amphiblestroid disease mainly contains retinal hemorrhage, oozes out, degeneration of macula, retinitis etc.; Can there is optic neuritis in optic nerve, optic atrophy etc.The common tumor of eye has squamous cell carcinoma of eyelid, occupancy tumor after retinoblastoma and ball.Be exactly ametropia i.e. myopia in addition, hypermetropia, astigmatism and the amblyopia that cannot correct.Color anomalopia chromatopsia can be divided into color weakness, protanopsia, deuteranopsia and achromatopsia again.
When great majority are treated, oculopathy all may relate to operative treatment, brings great misery, also increase Operative risk to patient.
At present, the medicine of market being treated oculopathy is a lot, mostly cures the symptoms, not the disease, and relapse rate is high and patient may be made to produce dependency to medicine.
 
Summary of the invention
The medicine for the treatment of oculopathy the object of the present invention is to provide a kind of rapid-action, good effect, having no side effect.
A kind of medicine for the treatment of oculopathy of the present invention, by weight, comprises following crude drug:
Semen Cassiae 12-17 part, Herba Dendrobii 12-17 part, Herba Senecionis Scandentis 10-15 part, Flos Chrysanthemi 8-13 part, Semen Celosiae 8-13 part, Borneolum Syntheticum 1-3 part.
A kind of medicine for the treatment of oculopathy of the present invention, by weight, also comprises following crude drug:
Vitamin B12 1-3 part.
A kind of medicine for the treatment of oculopathy of the present invention, by weight, comprises following crude drug:
Semen Cassiae 15 parts, Herba Dendrobii 15 parts, Herba Senecionis Scandentis 12 parts, Flos Chrysanthemi 10 parts, Semen Celosiae 10 parts, Borneolum Syntheticum 2 parts.
Treat a medicine for oculopathy as above, by weight, also comprise following crude drug:
Vitamin B12 2 parts.
A kind of medicine for the treatment of oculopathy of the present invention, wherein, described medicine is eye drop.
A kind of preparation method for the treatment of the medicine of oculopathy of the present invention, adopt Conventional eye drop preparation method, comprise the following steps:
(1) screen crude drug, take Semen Cassiae, Herba Dendrobii, Herba Senecionis Scandentis, Flos Chrysanthemi, Semen Celosiae and Borneolum Syntheticum by weight, clean, remove impurity;
(2) by each crude drug mix homogeneously, dry, sterilizing;
(3), after soaking 30-60min with crude drug total amount 10-15 times of water for injection, decoct 20-30min, filter, cool;
(4) sterilizing, subpackage, put in storage after quality inspection.
Wherein, vitamin B12 can be added after filtration, cooling.
The present invention compared with prior art, there is obvious beneficial effect, as can be known from the above technical solutions: the present invention selects Semen Cassiae, Herba Dendrobii, Herba Senecionis Scandentis, Flos Chrysanthemi, Semen Celosiae, Borneolum Syntheticum and vitamin B12 are raw material, by the synergism between each medicine, the inherent function of exciting human, eye is instilled by purification of tcm being become eye drop, plurality of active ingredients is made to arrive eye in the mode of infiltration, to supplement rapidly the nutrition needed for cell, impel ocular circulation, strengthen eye metabolism, make a cellular-restoring activity, thus reach the regeneration of promotion tissue repair, improve visual performance, treat the object of various oculopathy.It is rapid-action, good effect, relapse rate are low, zest is little, have no side effect, and medication is convenient and swift.Clinical 839 examples use, and the average cure rate for the treatment of ophthalmic bloated, glaucoma, trachoma, myopia, early cataract, keratitis, vitreous opacity, retinitis, dim eyesight is 91.5%.
 
Detailed description of the invention
the beneficial effect of medicine of the present invention is set forth further below by way of test example.
test example:the clinical observation of medicine of the present invention
Clinical data:
All cases 836 example.Wherein, male 400 example, women 436 example, max age 70 years old, minimal ages 3 years old.
Diagnostic criteria:
" doctor trained in Western medicine the standard of curative effect evaluation "
Therapeutic Method:
The eye drop instillation eye that medicine of the present invention is made, every day 1 time, each 1, eye drip 15-30 day.
Criterion of therapeutical effect:
Cure: main clinic symptoms disappears;
Effective: main clinic symptoms is alleviated to some extent;
Invalid: main clinic symptoms is not improved.
Therapeutic outcome:
167 routine ophthalmic bloated patients use medicine of the present invention, cure 165 examples, effective 1 example, invalid 1 example, and cure rate is 98.8%, and total effective rate is 99.4%;
75 routine glaucoma patients use medicine of the present invention, cure 72 examples, effective 2 examples, invalid 1 example, and cure rate is 96.0%, and total effective rate is 98.7%;
84 routine patients with trachomas use medicine of the present invention, cure 80 examples, effective 2 examples, invalid 2 examples, and cure rate is 95.2%, and total effective rate is 97.6%;
154 routine myopias use medicine of the present invention, cure 148 examples, effective 4 examples, invalid 2 examples, and cure rate is 96.1%, and total effective rate is 98.7%;
26 routine early cataract patients use medicine of the present invention, cure 17 examples, effective 6 examples, invalid 3 examples, and cure rate is 65.4%, and total effective rate is 88.5%;
95 routine keratitis patients use medicine of the present invention, cure 90 examples, effective 2 examples, invalid 3 examples, and cure rate is 94.7%, and total effective rate is 96.8%;
77 routine vitreous opacity patients use medicine of the present invention, cure 72 examples, effective 3 examples, invalid 2 examples, and cure rate is 93.5%, and total effective rate is 97.4%;
32 routine retinitis patients use medicine of the present invention, cure 28 examples, effective 1 example, invalid 3 examples, and cure rate is 87.5%, and total effective rate is 90.6%;
126 routine dim eyesight patients use medicine of the present invention, cure 121 examples, effective 3 examples, invalid 2 examples, and cure rate is 96.0%, and total effective rate is 98.4%;
Whole 836 routine patients use medicine of the present invention, and average cure rate is 91.5%, and average total effective rate is 96.2%.
embodiment 1
Treat a preparation method for the medicine of oculopathy, comprise the following steps:
(1) screen crude drug, take Semen Cassiae 12g, Herba Dendrobii 17g, Herba Senecionis Scandentis 10g, Flos Chrysanthemi 13g, Semen Celosiae 8g, Borneolum Syntheticum 3g, clean, remove impurity;
(2) by each crude drug mix homogeneously, dry, sterilizing;
(3), after soaking 30min with crude drug total amount 15 times of waters for injection, decoct 20min, filter, cool;
(4) sterilizing, subpackage, put in storage after quality inspection.
embodiment 2
Treat a preparation method for the medicine of oculopathy, comprise the following steps:
(1) screen crude drug, take Semen Cassiae 12g, Herba Dendrobii 17g, Herba Senecionis Scandentis 10g, Flos Chrysanthemi 13g, Semen Celosiae 8g, Borneolum Syntheticum 3g, clean, remove impurity;
(2) by each crude drug mix homogeneously, dry, sterilizing;
(3), after soaking 30min with crude drug total amount 15 times of waters for injection, decoct 20min, filter, cool;
(4) vitamin B12 1g is added;
(5) sterilizing, subpackage, put in storage after quality inspection.
embodiment 3
Treat a preparation method for the medicine of oculopathy, comprise the following steps:
(1) screen crude drug, take Semen Cassiae 17g, Herba Dendrobii 12g, Herba Senecionis Scandentis 15g, Flos Chrysanthemi 8g, Semen Celosiae 13g, Borneolum Syntheticum 1g, clean, remove impurity;
(2) by each crude drug mix homogeneously, dry, sterilizing;
(3), after soaking 60min with crude drug total amount 10 times of waters for injection, decoct 30min, filter, cool;
(4) sterilizing, subpackage, put in storage after quality inspection.
embodiment 4
Treat a preparation method for the medicine of oculopathy, comprise the following steps:
(1) screen crude drug, take Semen Cassiae 17g, Herba Dendrobii 12g, Herba Senecionis Scandentis 15g, Flos Chrysanthemi 8g, Semen Celosiae 13g, Borneolum Syntheticum 1g, clean, remove impurity;
(2) by each crude drug mix homogeneously, dry, sterilizing;
(3), after soaking 60min with crude drug total amount 10 times of waters for injection, decoct 30min, filter, cool;
(4) vitamin B12 3g is added;
(5) sterilizing, subpackage, put in storage after quality inspection.
embodiment 5
Treat a preparation method for the medicine of oculopathy, comprise the following steps:
(1) screen crude drug, take Semen Cassiae 15g, Herba Dendrobii 15g, Herba Senecionis Scandentis 12g, Flos Chrysanthemi 10g, Semen Celosiae 10g, Borneolum Syntheticum 2g, clean, remove impurity;
(2) by each crude drug mix homogeneously, dry, sterilizing;
(3), after soaking 45min with crude drug total amount 12 times of waters for injection, decoct 25min, filter, cool;
(4) sterilizing, subpackage, put in storage after quality inspection.
embodiment 6
Treat a preparation method for the medicine of oculopathy, comprise the following steps:
(1) screen crude drug, take Semen Cassiae 15g, Herba Dendrobii 15g, Herba Senecionis Scandentis 12g, Flos Chrysanthemi 10g, Semen Celosiae 10g, Borneolum Syntheticum 2g, clean, remove impurity;
(2) by each crude drug mix homogeneously, dry, sterilizing;
(3), after soaking 45min with crude drug total amount 12 times of waters for injection, decoct 25min, filter, cool;
(4) vitamin B12 2g is added;
(5) sterilizing, subpackage, put in storage after quality inspection.
 
The above, it is only preferred embodiment of the present invention, not any pro forma restriction is done to the present invention, anyly do not depart from technical solution of the present invention content, the any simple modification done above embodiment according to technical spirit of the present invention, equivalent variations and modification, all still belong in the scope of technical solution of the present invention.

Claims (5)

1. treat a medicine for oculopathy, by weight, comprise following crude drug: Semen Cassiae 12-17 part, Herba Dendrobii 12-17 part, Herba Senecionis Scandentis 10-15 part, Flos Chrysanthemi 8-13 part, Semen Celosiae 8-13 part, Borneolum Syntheticum 1-3 part.
2. a kind of medicine for the treatment of oculopathy as claimed in claim 1, is characterized in that: by weight, also comprises following crude drug: vitamin B12 1-3 part.
3. a kind of medicine for the treatment of oculopathy as claimed in claim 1, is characterized in that: by weight, comprises following crude drug: Semen Cassiae 15 parts, Herba Dendrobii 15 parts, Herba Senecionis Scandentis 12 parts, Flos Chrysanthemi 10 parts, Semen Celosiae 10 parts, Borneolum Syntheticum 2 parts.
4. a kind of medicine for the treatment of oculopathy as claimed in claim 3, is characterized in that: by weight, also comprises following crude drug: vitamin B12 2 parts.
5. a kind of medicine for the treatment of oculopathy as described in one of claim 1,2,3 or 4, is characterized in that: described medicine is eye drop.
CN201410739461.0A 2014-12-08 2014-12-08 A kind of medicine for treating illness in eye Active CN104435763B (en)

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107412317A (en) * 2017-07-17 2017-12-01 李占 The preparation method and element silicon eye drops of a kind of element silicon eye drops
CN108567910A (en) * 2017-03-13 2018-09-25 陕西新视明医药生物科技有限公司 The Chinese medicine composition of eye strain is alleviated in a kind of external application
CN108904709A (en) * 2018-09-18 2018-11-30 李淑华 A kind of pure Chinese medicine eye sticker and the preparation method and application thereof
CN109223856A (en) * 2017-07-04 2019-01-18 重庆沐沐瞳视力保健有限公司 A kind of eyedrops with supplement eye nutrient function
CN109331087A (en) * 2018-12-07 2019-02-15 怀化五零三侗医药科技开发有限公司 Eyeshield composition, eyeshield patch and its preparation method and application
CN110960605A (en) * 2019-12-27 2020-04-07 河南爱视力药业有限公司 Eye-protecting traditional Chinese medicine composition
CN111035676A (en) * 2020-01-13 2020-04-21 孙纯菊 Organic selenium eye drops for preventing and relieving eye diseases of old people and preparation method thereof
CN112190665A (en) * 2020-11-18 2021-01-08 郑州市新视明科技工程有限公司 Eye patch for relieving visual fatigue and preparation method thereof
CN113041321A (en) * 2021-04-23 2021-06-29 黑龙江荣耀方舟生物科技有限公司 External medicinal preparation for treating myopia and device

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JP2007277213A (en) * 2006-04-04 2007-10-25 Kazuaki Sugata Medicine for treating retinal disorder and use thereof
CN1965877A (en) * 2006-11-06 2007-05-23 赵因 Chinese medicinal eye drop for treating bacteria and virus infected conjunctivitis
CN101322743A (en) * 2008-08-01 2008-12-17 李翔 Formulation capable of repairing lesion and damnification of eye and improving asthenopia and preparation thereof

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108567910A (en) * 2017-03-13 2018-09-25 陕西新视明医药生物科技有限公司 The Chinese medicine composition of eye strain is alleviated in a kind of external application
CN109223856A (en) * 2017-07-04 2019-01-18 重庆沐沐瞳视力保健有限公司 A kind of eyedrops with supplement eye nutrient function
CN107412317A (en) * 2017-07-17 2017-12-01 李占 The preparation method and element silicon eye drops of a kind of element silicon eye drops
CN108904709A (en) * 2018-09-18 2018-11-30 李淑华 A kind of pure Chinese medicine eye sticker and the preparation method and application thereof
CN109331087A (en) * 2018-12-07 2019-02-15 怀化五零三侗医药科技开发有限公司 Eyeshield composition, eyeshield patch and its preparation method and application
CN110960605A (en) * 2019-12-27 2020-04-07 河南爱视力药业有限公司 Eye-protecting traditional Chinese medicine composition
CN111035676A (en) * 2020-01-13 2020-04-21 孙纯菊 Organic selenium eye drops for preventing and relieving eye diseases of old people and preparation method thereof
CN112190665A (en) * 2020-11-18 2021-01-08 郑州市新视明科技工程有限公司 Eye patch for relieving visual fatigue and preparation method thereof
CN113041321A (en) * 2021-04-23 2021-06-29 黑龙江荣耀方舟生物科技有限公司 External medicinal preparation for treating myopia and device

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