CN105250394A - Traditional Chinese medicine composition for treating cataract and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for treating cataract and preparation method and application thereof Download PDFInfo
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- CN105250394A CN105250394A CN201510711515.7A CN201510711515A CN105250394A CN 105250394 A CN105250394 A CN 105250394A CN 201510711515 A CN201510711515 A CN 201510711515A CN 105250394 A CN105250394 A CN 105250394A
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Abstract
The invention discloses a traditional Chinese medicine composition for treating cataract and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from, by mass, 6-10 parts of plantain herb, 15-25 parts of caltrop and 9-15 parts of spiny amarauth herb. The raw materials are mixed in proportion, an ethanol solution is added, heating is perform to achieve boiling reflux for 3-5 hours, filtering is performed, a diacolation method is adopted to collect diacolation liquid, reduced pressure concentration is performed to obtain thick paste, and spray drying and smashing are performed to obtain powder; cane sugar powder and dextrin are added into the obtained dried powder, and drying is performed at the temperature of 45-55 DEG C to obtain granules. The traditional Chinese medicine composition has the effects of tonifying the liver and kidney, replenishing qi to invigorate the spleen, soothing liver-qi stagnation, improving eyesight, removing nebula, clearing away heat and toxic materials, dispelling wind-evil and opening orifices. Clinical application verifies that the traditional Chinese medicine composition is remarkable and reliable in treating effect, mild in medicine property, short in treatment course, quick in effect and free of toxic and side effects, and the cataract does not easily relapse after being cured.
Description
Technical field
The present invention relates to technical field of Chinese medicines, specifically one treats cataractous Chinese medicine composition and preparation method thereof and purposes.
Background technology
Cataract is a kind of common ocular disease, it is a kind of disease that can cause blindness, cause cataractous factor a lot, such as: the factor such as aging, hereditary, Developmental and Metabolic Disorder, wound, radiation, poisoning and local malnutrition can cause phacocyst membrane damage or cause crystalline lens metabolism disorder, crystallin generation degeneration and muddy is caused.Cataractous symptom is blurred vision, keeps in dark place, looks more, near-sighted degree increases, sees that object color is comparatively dark or in yellow, even ghost image and see the symptoms such as deformation of body.Show as vision Progressive symmetric erythrokeratodermia to go down, sometimes can see fixing stain under the background of light.Main and the nutrient metabolic of cataractous pathogenic factor, sunlight and ultraviolet, extraneous temperature, anoxia, endocrine regulation, it is relevant to there is the factors such as dehydration in human body.According to investigation, cataract is modal blinding and reason with visual disabilities, and the mankind about 25% suffer from cataract, and the sickness rate of 50 ~ 60 years old senile cataract is 60 ~ 70%, more than 70 years old reach 80%, the old people of more than 80 years old almost reaches 100%.
At present, for cataractous treatment, doctor trained in Western medicine based on operative treatment, curative effect still can, but postoperatively may occur multiple complication, directly affect therapeutic effect, not only during treatment, patient suffers misery, and somewhat expensive.The waiting time of operative treatment is longer, 1 ~ 2 year at least, and many decades can be ripe at most, just can perform the operation when vision only has photosensitive.Postcataract may cause a series of complication, and the patient suffering from hypertension, heart disease or other diseases should not perform the operation.Treat cataractous Western medicine to cure the symptoms, not the disease often, though symptom is alleviated for the moment, drug effect is decorporated, symptom resume combustion, can not tackle the problem at its root; Treat cataractous Chinese medicine also a lot, but due to the particularity of eyes, and the multiformity of pathogenesis of cataract reason, often making Chinese medicine effect when treating cataract remarkable, effectively can not solve sufferer.
Amaranthus spinosus L., another name Amaranthusspinosus L., Herba amaranthi ascendentis, wild Amaranthusspinosus L., false Amaranthus mangostanus L., pig mother thorn, Cortex Acanthopanacis Radicis Herba Amaranthi tricoloris, be Amaranthaceae Amaranthus Amaranthusspinosus L., be used as medicine with herb or root, stem, leaf, cool in nature, sweet in the mouth, light, has effect of clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, cooling blood for hemostasis.For dysentery, enteritis, taste-blindness rate is hemorrhage, hemorrhoidal hemorrhage; Venom is controlled in external, skin eczema, furuncle and phyma pus infections.
Summary of the invention
The object of the present invention is to provide a kind of evident in efficacy, instant effect, have no side effect and more after the cataractous Chinese medicine composition for the treatment of that not easily recurs and preparation method thereof and purposes.
For achieving the above object, the invention provides following technical scheme:
One treats cataractous Chinese medicine composition, according to mass fraction, is made up of Herba Plantaginis 6 ~ 10 parts, Fructus Tribuli 15 ~ 25 parts and Amaranthus spinosus L. 9 ~ 15 parts.
As the further scheme of the present invention: according to mass fraction, be made up of Herba Plantaginis 7 ~ 8 parts, Fructus Tribuli 20 ~ 24 parts and Amaranthus spinosus L. 10 ~ 13 parts.
As the further scheme of the present invention: according to mass fraction, be made up of Herba Plantaginis 8 parts, Fructus Tribuli 22 parts and Amaranthus spinosus L. 12 parts.
The preparation method of the cataractous Chinese medicine composition of described treatment, comprises the following steps:
(1) above-mentioned raw materials is mixed in proportion obtains mixture, the volumetric concentration adding 8 ~ 10 times amount of its quality in mixture is the alcoholic solution of 85 ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 60 ~ 65 DEG C subsequently under vacuum 0.07 ~ 0.08MPa, relative density is the thick paste of 1.12 ~ 1.13, spray-dried, pulverize and make dry powder;
(2) in the dry powder obtained, add the dextrin of the cane sugar powder of 0.3 ~ 0.35 times of dry powder quality and 0.22 ~ 0.28 times of dry powder quality, make granule, in 45 ~ 55 DEG C of dryings, obtain granule.
The purposes of described Chinese medicine composition in the cataractous medicine of preparation treatment.
Compared with prior art, the invention has the beneficial effects as follows:
The selected medicament composing prescription of the present invention, based on the Fructus Tribuli of suppressing the hyperactive liver resolving depression, promoting blood circulation by removing wind, improving eyesight, with heat-clearing and toxic substances removing, detumescence the Amaranthus spinosus L. of dampness removing and the Herba Plantaginis of heat-clearing and toxic substances removing be auxiliary, this three tastes Chinese medicine scientific compatibility, bring out the best in each other, play effect of the liver and the kidney tonifying, replenishing QI to invigorate the spleen, dispersing the stagnated live-QI to relieve the stagnation of QI, improving acuity of vision and removing nebula, heat-clearing and toxic substances removing, expelling pathogenic wind and restoring the functions of orifices in face altogether, treating both the principal and secondary aspects of a disease is reached to cataractous treatment.
The present invention all adopts natural raw material of Chinese medicine, and its preparation is simple, medicine source is wide, cost is low.Through clinical practice checking, it is reliably evident in efficacy, mild in medicine property and, short treating period, instant effect, has no side effect, and more after not easily recur.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, be clearly and completely described the technical scheme in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
Embodiment 1
In the embodiment of the present invention, one treats cataractous Chinese medicine composition, according to mass fraction, is made up of Herba Plantaginis 6 parts, Fructus Tribuli 25 parts and Amaranthus spinosus L. 9 parts.
The preparation method of the cataractous Chinese medicine composition of described treatment, comprises the following steps:
(1) above-mentioned raw materials is mixed in proportion obtains mixture, the volumetric concentration adding 10 times amount of its quality in mixture is the alcoholic solution of 85%, be heated to boiling reflux 5 hours, filter, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being evaporated to 65 DEG C subsequently under vacuum 0.08MPa, relative density is the thick paste of 1.12, spray-dried, pulverize and make dry powder;
(2) in the dry powder obtained, add the dextrin of the cane sugar powder of 0.35 times of dry powder quality and 0.22 times of dry powder quality, make granule, in 55 DEG C of dryings, obtain granule.
Embodiment 2
In the embodiment of the present invention, one treats cataractous Chinese medicine composition, according to mass fraction, is made up of Herba Plantaginis 7 parts, Fructus Tribuli 24 parts and Amaranthus spinosus L. 10 parts.
The preparation method of the cataractous Chinese medicine composition of described treatment, comprises the following steps:
(1) above-mentioned raw materials is mixed in proportion obtains mixture, the volumetric concentration adding 8 times amount of its quality in mixture is the alcoholic solution of 95%, be heated to boiling reflux 3 hours, filter, adopt percolation with the speed of 1ml per minute slowly percolation, collect percolate, when being evaporated to 60 DEG C subsequently under vacuum 0.07MPa, relative density is the thick paste of 1.13, spray-dried, pulverize and make dry powder;
(2) in the dry powder obtained, add the dextrin of the cane sugar powder of 0.3 times of dry powder quality and 0.28 times of dry powder quality, make granule, in 45 DEG C of dryings, obtain granule.
Embodiment 3
In the embodiment of the present invention, one treats cataractous Chinese medicine composition, according to mass fraction, is made up of Herba Plantaginis 8 parts, Fructus Tribuli 22 parts and Amaranthus spinosus L. 12 parts.
The preparation method of the cataractous Chinese medicine composition of described treatment, comprises the following steps:
(1) above-mentioned raw materials is mixed in proportion obtains mixture, the volumetric concentration adding 9 times amount of its quality in mixture is the alcoholic solution of 90%, be heated to boiling reflux 4 hours, filter, adopt percolation with the speed of 1ml per minute slowly percolation, collect percolate, when being evaporated to 65 DEG C subsequently under vacuum 0.07MPa, relative density is the thick paste of 1.13, spray-dried, pulverize and make dry powder;
(2) in the dry powder obtained, add the dextrin of the cane sugar powder of 0.32 times of dry powder quality and 0.25 times of dry powder quality, make granule, in 50 DEG C of dryings, obtain granule.
Embodiment 4
In the embodiment of the present invention, one treats cataractous Chinese medicine composition, according to mass fraction, is made up of Herba Plantaginis 9 parts, Fructus Tribuli 19 parts and Amaranthus spinosus L. 10 parts.
The preparation method of the cataractous Chinese medicine composition of described treatment, comprises the following steps:
(1) above-mentioned raw materials is mixed in proportion obtains mixture, the volumetric concentration adding 8 times amount of its quality in mixture is the alcoholic solution of 95%, be heated to boiling reflux 3 hours, filter, adopt percolation with the speed of 1ml per minute slowly percolation, collect percolate, when being evaporated to 60 DEG C subsequently under vacuum 0.07MPa, relative density is the thick paste of 1.13, spray-dried, pulverize and make dry powder;
(2) in the dry powder obtained, add the dextrin of the cane sugar powder of 0.3 times of dry powder quality and 0.28 times of dry powder quality, make granule, in 45 DEG C of dryings, obtain granule.
Embodiment 5
In the embodiment of the present invention, one treats cataractous Chinese medicine composition, according to mass fraction, is made up of Herba Plantaginis 10 parts, Fructus Tribuli 15 parts and Amaranthus spinosus L. 15 parts.
The preparation method of the cataractous Chinese medicine composition of described treatment, comprises the following steps:
(1) above-mentioned raw materials is mixed in proportion obtains mixture, the volumetric concentration adding 10 times amount of its quality in mixture is the alcoholic solution of 85%, be heated to boiling reflux 5 hours, filter, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being evaporated to 65 DEG C subsequently under vacuum 0.08MPa, relative density is the thick paste of 1.12, spray-dried, pulverize and make dry powder;
(2) in the dry powder obtained, add the dextrin of the cane sugar powder of 0.35 times of dry powder quality and 0.22 times of dry powder quality, make granule, in 55 DEG C of dryings, obtain granule.
Below for Chinese medicine composition of the present invention being applied to the basic document of cataractous clinical treatment:
Clinical data
1, case selection
Select the routine clinical observation of cataract patient 350 of making a definite diagnosis, wherein male 154 example, women 146 example, 46 ~ 78 years old age, 55.2 years old mean age, the course of disease 2 ~ 8 years, average 5 years.All patients all have visual disorder in various degree, get rid of and merge other eye part diseases, as glaucoma, retinopathy, high myopia etc.This 350 routine patient is divided into seven groups at random, is respectively treatment 1 ~ 5 group, contrast 1 ~ 2 group, often organize 50 examples, the sex between each group, age and course of disease length there was no significant difference, have comparability.
2, Therapeutic Method
Treat 1 ~ 5 group and take the obtained Chinese medicine composition of embodiment 1 ~ 5 respectively, every day twice, early, evening is each each serving with the dosage being equivalent to 42g crude drug amount, within 20 days, is once a course for the treatment of, uses 3 courses for the treatment of continuously.
Contrast 1 group of Chinese medicine composition taken only containing Fructus Tribuli and Amaranthus spinosus L., all the other conditions are consistent with embodiment 3.Every day twice, early, evening is each once, each serving with the dosage being equivalent to 42g crude drug amount, within 20 days, is a course for the treatment of, uses 3 courses for the treatment of continuously.
Contrast 3 groups of Chinese medicine compositions taken only containing Herba Plantaginis, all the other conditions are consistent with embodiment 3.Every day twice, early, evening is each once, each serving with the dosage being equivalent to 42g crude drug amount, within 20 days, is a course for the treatment of, uses 3 courses for the treatment of continuously.
Treatments period, does not re-use other Drug therapy.
3, efficacy determination
(1) effective: vision improves significantly or improves more than 5 row, the transference cures such as blurred vision, and examination with slitlamp microscope lenticular opacity obviously alleviates;
(2) effective: vision improves more than 3 row, the large portion of the symptoms such as blurred vision disappears, and examination with slitlamp microscope lenticular opacity alleviates;
(3) improve: the symptoms such as vision improves more than 1 row, blurred vision take a turn for the better, and examination with slitlamp microscope lenticular opacity slightly alleviates;
(4) invalid: vision is without improve, and the symptoms such as blurred vision are without improvement or increase the weight of, and examination with slitlamp microscope lenticular opacity thing increases the weight of without change or muddiness.
4, therapeutic outcome
The efficacy result that table 1 is respectively organized
| Group | Case load | Effective number | Significant figure | Improve number | Invalid number | Obvious effective rate | Effective percentage |
| Treat 1 group | 50 | 24 | 10 | 12 | 4 | 48％ | 92％ |
| Treat 2 groups | 50 | 27 | 8 | 12 | 3 | 54％ | 94％ |
| Treat 3 groups | 50 | 28 | 14 | 6 | 2 | 56％ | 96％ |
| Treat 4 groups | 50 | 26 | 9 | 12 | 3 | 52％ | 94％ |
| Treat 5 groups | 50 | 23 | 10 | 13 | 4 | 46％ | 92％ |
| Contrast 1 group | 50 | 3 | 5 | 2 | 40 | 6％ | 20％ |
| Contrast 2 groups | 50 | 0 | 3 | 1 | 46 | 0％ | 6％ |
After the treatment of 3 courses for the treatment of, the curative effect of each group is as shown in table 1: as can be seen from the table, adopt Chinese medicine composition of the present invention can significantly improve cataractous treatment curative effect.Especially, in clinical observation process, the curative effect of medication of Chinese medicine composition of the present invention is definite, does not find that patient has untoward reaction and anaphylaxis, illustrates that this product is safe and effective.
5, model case
Case 1: Yao, 59 years old, there is the symptom of vision degradation, be diagnosed as cataract through examination in hospital in female, because patient and family members are unwilling to perform an operation, determines to adopt expectant treatment in the recent period; Through taking the obtained water decoction of the embodiment of the present invention 3 after one month, vision is taken a turn for the better, and after continuing to take the embodiment of the present invention 3 obtained two courses for the treatment of of decoction, vision is recovered completely, and through hospital's check, indices all shows normally, fully recovers.Follow up a case by regular visits to half a year, without recurrence.
Case 2: strict certain, man, 68 years old, suffers from cataract more than 3 years, and, distending pain sour and astringent with eyes, and in the recent period, visual deterioration more serious, owing to cannot bear the nurse fees use of operation and later stage, determines to adopt Drug therapy; After taking the embodiment of the present invention 3 obtained course for the treatment of of decoction, vision is obviously recovered, and does not delay daily life, and hold on after taking the embodiment of the present invention 3 obtained two courses for the treatment of of decoction, vision is recovered completely, have seen the world clearly again, recovery from illness.Follow up a case by regular visits to half a year, without recurrence.
To those skilled in the art, obviously the invention is not restricted to the details of above-mentioned one exemplary embodiment, and when not deviating from spirit of the present invention or basic feature, the present invention can be realized in other specific forms.Therefore, no matter from which point, all should embodiment be regarded as exemplary, and be nonrestrictive, scope of the present invention is limited by claims instead of above-mentioned explanation, and all changes be therefore intended in the implication of the equivalency by dropping on claim and scope are included in the present invention.
In addition, be to be understood that, although this description is described according to embodiment, but not each embodiment only comprises an independently technical scheme, this narrating mode of description is only for clarity sake, those skilled in the art should by description integrally, and the technical scheme in each embodiment also through appropriately combined, can form other embodiments that it will be appreciated by those skilled in the art that.
Claims (5)
1. treat a cataractous Chinese medicine composition, it is characterized in that, according to mass fraction, be made up of Herba Plantaginis 6 ~ 10 parts, Fructus Tribuli 15 ~ 25 parts and Amaranthus spinosus L. 9 ~ 15 parts.
2. the cataractous Chinese medicine composition for the treatment of according to claim 1, is characterized in that, according to mass fraction, is made up of Herba Plantaginis 7 ~ 8 parts, Fructus Tribuli 20 ~ 24 parts and Amaranthus spinosus L. 10 ~ 13 parts.
3. the cataractous Chinese medicine composition for the treatment of according to claim 1, is characterized in that, according to mass fraction, is made up of Herba Plantaginis 8 parts, Fructus Tribuli 22 parts and Amaranthus spinosus L. 12 parts.
4. a preparation method for the cataractous Chinese medicine composition for the treatment of as described in as arbitrary in claims 1 to 3, is characterized in that, comprise the following steps:
(1) above-mentioned raw materials is mixed in proportion obtains mixture, the volumetric concentration adding 8 ~ 10 times amount of its quality in mixture is the alcoholic solution of 85 ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 60 ~ 65 DEG C subsequently under vacuum 0.07 ~ 0.08MPa, relative density is the thick paste of 1.12 ~ 1.13, spray-dried, pulverize and make dry powder;
(2) in the dry powder obtained, add the dextrin of the cane sugar powder of 0.3 ~ 0.35 times of dry powder quality and 0.22 ~ 0.28 times of dry powder quality, make granule, in 45 ~ 55 DEG C of dryings, obtain granule.
5. the purposes of the Chinese medicine composition as described in as arbitrary in claims 1 to 3 in the cataractous medicine of preparation treatment.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105998431A (en) * | 2016-06-29 | 2016-10-12 | 曹蕊 | Traditional Chinese medicine composition for treating cataract and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105998431A (en) * | 2016-06-29 | 2016-10-12 | 曹蕊 | Traditional Chinese medicine composition for treating cataract and preparation method thereof |
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