CN104435635A - Traditional Chinese medicine composition for treating postmenopausal coronary heart disease - Google Patents

Traditional Chinese medicine composition for treating postmenopausal coronary heart disease Download PDF

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CN104435635A
CN104435635A CN201410713898.7A CN201410713898A CN104435635A CN 104435635 A CN104435635 A CN 104435635A CN 201410713898 A CN201410713898 A CN 201410713898A CN 104435635 A CN104435635 A CN 104435635A
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herba
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刘宁
刘伟伟
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Abstract

The invention discloses a traditional Chinese medicine composition for treating a postmenopausal coronary heart disease. The traditional Chinese medicine composition is prepared from the following medicinal raw materials including flatstem milkvetch seeds, fluoritum, all-grasses of thellung pimpinella, asparagus cochinchinensis, medicinal changium roots, yerbadetajo herbs, gynostemma pentaphylla, vietnamese sophora roots, stems of sargentgloryvine, common St. paulswort herbs, prepared myrrh and ground beetles. The traditional Chinese medicine composition strikes pathological mechanisms of the postmenopausal coronary heart disease and is obvious in effect of treating the postmenopausal coronary heart disease without inducing complications including venous thrombosis and breast cancer. With the adoption of the traditional Chinese medicine composition, 60 patients are treated by adopting water decoctions of the traditional Chinese medicine composition for treating the postmenopausal coronary heart disease, after 6-month treatment, 30 patients are cured, 24 patients mend, 6 patients are not cured, and the total effective rate is 90 percent; after 3 months, the estradiol (E2) level of the patients gradually rises and is remarkable in difference (P is smaller than 0.01) compared with that before treatment.

Description

One treats Menopause uterine hemorrhage Chinese medicine composition
Technical field
The present invention relates to Chinese medicine sciemtifec and technical sphere, particularly one treats Menopause uterine hemorrhage Chinese medicine composition.
Background technology
Women's post menopausal body inner estrogen level occurs obviously to change, and causes many biological metabolism system disorders and physiological change, causes various disease, comprising coronary heart disease.Pre-menopausal Women Incidence of CHD is lower than same age level male; its reason is just unique protective factors-estrogen of women's cardiovascular system; large quantity research confirms that estrogen can improve lipid metabolism; coronary artery dilator; directly or indirectly delay Coronary Atherosclerotic Plaque development, thus protection women cardiovascular system.And after menopause, hypo-ovaria and the endogenous estrogen caused thus lack, directly facilitate the generation of coronary heart disease.Controversies in hormone replacement in the elderly can reduce postmenopausal women coronary heart disease clinical events incidence rate and case fatality rate, but causes phlebothrombosis to be maximum additional risk, and breast cancer risk occurs increases along with the prolongation of Applicative time.Chinese medicine has carried out a large amount of basis and clinical research for Female Climacteric Syndrome, but lacks further investigated to Menopause uterine hemorrhage.Therefore, develop good effect, the Chinese medicine composition of few side effects substitutes estrin treatment Menopause uterine hemorrhage and have important clinical significance.
Summary of the invention
The object of the invention is to overcome above-mentioned deficiency existing in prior art, provide one to treat Menopause uterine hemorrhage Chinese medicine composition.
In order to realize foregoing invention object, the invention provides following technical scheme:
One treats Menopause uterine hemorrhage Chinese medicine composition, the medicament be made up of the crude drug of following mass ratio:
Semen Astragali Complanati 10 ~ 20 parts, Fluoritum 9 ~ 15 parts, Herba Pimpinellae thellungianae 12 ~ 18 parts, Radix Asparagi 8 ~ 12 parts, Radix Changii 9 ~ 15 parts, Herba Ecliptae 8 ~ 12 parts, Herb Gynostemmae Pentaphylli 10 ~ 20 parts, Radix Sophorae Tonkinensis 4 ~ 8 parts, Caulis Sargentodoxae 9 ~ 15 Fen, Herba Siegesbeckiae 15 ~ 25 parts, Myrrha (processed) 6 ~ 10 parts, Eupolyphaga Seu Steleophaga 4 ~ 8 parts.
Semen Astragali Complanati: sweet, warm, returns liver, kidney channel.Tonifying the kidney to consolidate the essence, nourishing the liver to improve visual acuity.Cure mainly: lumbago due to renal deficiency, impotence and seminal emission, enuresis frequent micturition, leukorrhagia; Poor vision, dizziness and dim eyesight.Semen Astragali Complanati has antifatigue effect; Can also blood pressure lowering, reduce serum cholesterol, triglyceride, increase the effect of cerebral blood flow, and improve hemorheology index.
Fluoritum: sweet, warm, GUIXIN, lung, kidney channel.Warming the kidney to activate YANG, tranquilizing mind, warming the lung is relievingd asthma.Cure mainly kidney yang virtual loss, cold womb is infertile, bleeding not during menses; Severe palpitation, restlessness of asrhenia type and insomnia; The lung cold leading to abnormal rising of QI, abundant expectoration cough with asthma.Fluoritum has stimulating central nervous system, promotes the effect of ovarian secretion.
Herba Pimpinellae thellungianae: pungent, sweet, warm, GUIXIN, kidney, lung, spleen channel.Warming the kidney to activate YANG, blood circulation promoting and blood stasis dispelling, tranquilizing by nourishing the heart, warming lung for dispelling cold.Cure mainly sexual impotence erectile problem, oligospermia cold sperm; Qi depression to blood stasis, obstruction of qi in the chest and cardialgia; Palpitation and insomnia, sensation of oppression over the chest with shortness of breath; Affection of exogenous wind-cold, cold fluid-retention is coughed.Herba Pimpinellae thellungianae can strengthen the activity of cardiac muscle and cerebral tissue respiratory enzyme; There is obvious hypotensive effect, and there is certain strong effect.
Radix Asparagi: sweet, bitter, cold, returns lung, kidney, stomach warp.Nourishing YIN to relieve dryness, lung heat clearing is promoted the production of body fluid.Cure mainly syndrome of deficiency of lung yin; Syndrome of deficiency of kidney yin; The cards such as the inappetence of consumption of body fluid caused by febrile disease, thirsty and dryness of the intestine constipation.Radix Asparagi can make peripheral blood vessel expansion, blood pressure drops, contractile force enhancing, decreased heart rate and urine volume increase.
Radix Changii: sweet, micro-hardship, to be slightly cold, returns lung, spleen, Liver Channel.Moistening the lung and resolving phlegm, yin nourishing stomach function regulating, suppressing the hyperactive liver.Cure mainly syndrome of deficiency of lung yin; Syndrome of yin deficiency of spleen and stomach; Deficiecny of liver-YIN or liver-heat are attacked the card such as dizzy, headache, conjunctival congestion extremely.Radix Changii can reduce the serum cholesterol of laboratory animal, improves the ratio of high density lipoprotein and cholesterol, increases serum superoxide dismutase, reduces Serum MDA; The activity of mouse spleen lymphocyte NK can be improved, suppress the delayed hypersensitivity reaction caused by dinitrochlorobenzene; Also have anoxia enduring, high temperature resistance, fatigue-resisting function.
Herba Ecliptae: sweet, sour, cold, returns liver, kidney channel.Nourishing the liver and kidney, cooling blood for hemostasis.Cure mainly syndrome of yin deficiency of liver and kidney, the card of losing blood of YinXuXueRe.Herba Ecliptae has the effect improving body non-specific immunity, oxygen-derived free radicals can be eliminated to suppress 5-lipoxygenase, protection chromosome, protect the liver, promote hepatocellular regeneration, increase coronary flow, extend the life of mice under normobaric hypoxia, improve the survival rate of mice in hypobaric hypoxia situation; And have calmness, analgesia, promotion hair growth, make hair blackening, hemostasis, antibacterial, anti-ameba, the effect such as anticancer.
Herb Gynostemmae Pentaphylli: sweet, bitter, cold, returns spleen, lung meridian.Replenishing QI to invigorate the spleen, preventing phlegm from forming and stopping coughing, heat-clearing and toxic substances removing.Cure mainly syndrome of spleen-deficiency, cough due to deficiency of the lung demonstrate,proves.Herb Gynostemmae Pentaphylli and gypenoside all have resisting fatigue, anti-hypoxia, high temperature resistance, anti-cold service; Obviously can increase the function of nonspecific immunity, cellular immunization, humoral immunization, and tool immunoregulation effect; There is obvious blood fat reducing, hypoglycemic activity, and the synthesis rate of spleen, testis, brain and hematoglobin protein can be improved, and there is calmness, hypnosis, analgesia, increase coronary flow, resist myocardial ischemia, increase cerebral blood flow, inhibition thrombosis, protect the liver, the effect such as antiulcer.
Radix Sophorae Tonkinensis: bitter, cold, poisonous, attaches to the lung and stomach meridians.Heat-clearing and toxic substances removing, relieving sore throat and diminishing swelling.Cure mainly laryngopharynx swelling and pain; Gingival swelling and pain.Radix Sophorae Tonkinensis has rising leukocyte, antiarrhythmic effect, antiinflammatory action and hepatoprotective effect.
Caulis Sargentodoxae: bitter, flat, returns large intestine, Liver Channel.Heat-clearing and toxic substances removing, invigorates blood circulation, and dispels the wind, pain relieving.Cure mainly abdominalgia with intestinal abscess, pathopyretic ulcer; Traumatic injury, amenorrhea dysmenorrhea; Rheumatic arthralgia.Caulis Sargentodoxae has stronger bacteriostasis, can increase coronary flow, inhibition thrombosis.
Herba Siegesbeckiae: cold, pungent, bitter, returns Liver Channel, kidney channel.Wind-damp dispelling, sharp joint, removing toxic substances.Cure mainly that rheumatic arthralgia, muscles and bones are unable, soreness of the waist and knees, quadriplegia, hemiplegia, rubella eczema.Herba Siegesbeckiae has antiinflammatory, blood pressure lowering, vasodilator, immunosuppressant, anticoagulant, the effect such as antibacterial.
Myrrha (processed): pungent, bitter, flat, GUIXIN, liver, spleen channel.Promoting blood circulation and stopping pain, detumescence and promoting granulation.Cure mainly the stagnant pain of the traumatic injury stasis of blood, ulcer sore pain, skin infection does not close up after bursting and the stagnant pain card of all stasis of bloods for a long time.Myrrha (processed) has blood fat reducing, prevents the effect of endarterium atherosclerosis plaque forming.
Eupolyphaga Seu Steleophaga: salty, cold, slightly poisonous, returns Liver Channel.Removing blood stasis, reunion of fractured tendons and bones.Cure mainly traumatic injury, the injury of tendon and muscle is fractured, pain caused by ecchymoma; Blood stasis amenorrhea, the stagnant stomachache of the stasis of blood in puerperal, gathers mass in the abdomen.Eupolyphaga Seu Steleophaga has antithrombus formation and thrombolytic effect; Can anticoagulant and adhesion rate, reduce aggregation number; Cardiac muscle and brain can be improved to the tolerance of ischemia, and reduce the oxygen consumption of the heart, cerebral tissue; There is Regulation serum lipids, atherosclerotic formation can be delayed; And the hepatic injury caused by D-galactose can be suppressed and have hepatoprotective effect.
Coronary heart disease belongs to the category such as the traditional Chinese medical science " thoracic obstruction ", " pained ", and its sick position, at the heart, belongs to the card of deficiency in origin and excess in superficiality.There is the record of " kidney patient ... void is chest pain then " in "Nei Jing", emphasize the critical role of suffering from a deficiency of the kidney in the thoracic obstruction, pained morbidity.Because of essence and blood sharing the same origin, if deficiency of kidney-essence, the raw painstaking effort of being difficult, deficiency of heart-blood declines, and the heart is become homeless foster, " not flourish and pain "; If kidney yang deficiency, can not inspire YANG of five ZANG-organs, flaccidity of the heart-yang, blood vessels lose in warm, then cold in blood and coagulating; In addition the traditional Chinese medical science think feminine menstrual rise with break off with the profit and loss of kidney qi, menses to exhausting, appoint a prosperity and decline of rushing to have direct relation, and kidney qi is in leading position.Therefore Menopause uterine hemorrhage is with kidney asthenia as the principal aspect, and blood stasis is mark.Treatment, based on the kidney warming replenishing essence, takes into account blood circulation promoting and blood stasis dispelling.The present invention adopts Semen Astragali Complanati, Fluoritum, Herba Pimpinellae thellungianae the kidney invigorating warming YANG; Radix Asparagi, Radix Changii, Herba Ecliptae nourishing the liver and kidney; Herb Gynostemmae Pentaphylli replenishing QI to invigorate the spleen, makes QI and blood biochemistry active; Radix Sophorae Tonkinensis, Caulis Sargentodoxae, Herba Siegesbeckiae blood circulation promoting and blood stasis dispelling; Myrrha (processed), the pain relieving of Eupolyphaga Seu Steleophaga removing blood stasis.All medicines share, and hit pathogenesis.
Preferably, the medicament be made up of the crude drug of following mass ratio of described treatment Menopause uterine hemorrhage Chinese medicine composition:
Semen Astragali Complanati 13 ~ 17 parts, Fluoritum 11 ~ 13 parts, Herba Pimpinellae thellungianae 14 ~ 16 parts, Radix Asparagi 9 ~ 11 parts, Radix Changii 11 ~ 13 parts, Herba Ecliptae 9 ~ 11 parts, Herb Gynostemmae Pentaphylli 13 ~ 17 parts, Radix Sophorae Tonkinensis 5 ~ 7 parts, Caulis Sargentodoxae 11 ~ 13 Fen, Herba Siegesbeckiae 18 ~ 22 parts, Myrrha (processed) 7 ~ 9 parts, Eupolyphaga Seu Steleophaga 5 ~ 7 parts.
Preferred further, the medicament that described treatment Menopause uterine hemorrhage Chinese medicine composition is made up of the crude drug of following mass ratio:
Semen Astragali Complanati 15 parts, Fluoritum 12 parts, Herba Pimpinellae thellungianae 15 parts, Radix Asparagi 10 parts, Radix Changii 12 parts, Herba Ecliptae 10 parts, Herb Gynostemmae Pentaphylli 15 parts, Radix Sophorae Tonkinensis 6 parts, Caulis Sargentodoxae 12 Fen, Herba Siegesbeckiae 20 parts, Myrrha (processed) 8 parts, Eupolyphaga Seu Steleophaga 6 parts.
Described treatment Menopause uterine hemorrhage Chinese medicine composition can adopt existing Chinese medicine preparation technology to be prepared into any conventional oral preparations, such as can decocting be adopted to obtain water decoction said components, by other existing Chinese medicine preparation technology, described treatment Menopause uterine hemorrhage Chinese medicine composition can also be prepared into tablet, water-honeyed pill, capsule, powder, unguentum, oral liquid, granule.
Compared with prior art, beneficial effect of the present invention
Treatment Menopause uterine hemorrhage Chinese medicine composition provided by the invention, the pathomechanism of the Menopause uterine hemorrhage that hits, treatment Menopause uterine hemorrhage successful, not easily brings out the complication such as phlebothrombosis, breast carcinoma.
One treats Menopause uterine hemorrhage Chinese medicine composition, and clinical efficacy is summed up
1 physical data
60 routine patients, 46 ~ 50 years old age, menopause all more than 2 years, all meet the name of WHO ischemic heart desease in 1979 and diagnostic criteria [International Society of Cardiology and association and World Health Organization's clinical name standard association special topic group. the name of ischemic heart desease and diagnostic criteria. Chinese Journal of Cardiology 1981; 9 (1): 75].
2 Therapeutic Method
Semen Astragali Complanati 10 ~ 20 grams, Fluoritum 9 ~ 15 grams, Herba Pimpinellae thellungianae 12 ~ 18 grams, Radix Asparagi 8 ~ 12 grams, Radix Changii 9 ~ 15 grams, Herba Ecliptae 8 ~ 12 grams, Herb Gynostemmae Pentaphylli 10 ~ 20 grams, Radix Sophorae Tonkinensis 4 ~ 8 grams, Caulis Sargentodoxae 9 ~ 15 Ke, Herba Siegesbeckiae 15 ~ 25 grams, Myrrha (processed) 6 ~ 10 grams, Eupolyphaga Seu Steleophaga 4 ~ 8 grams.Conveniently Chinese medicine preparation technology makes water decoction, everyone potion every day.
4 therapeutic outcomes
4.1 criterions of therapeutical effect: reference " Chinese medical disease Standardization of diagnosis and curative effect " (State Administration of Traditional Chinese Medicine. Chinese medical disease Standardization of diagnosis and curative effect. Nanjing: Nanjing University goes out society, the criterion of therapeutical effect of obstruction of qi in the chest and cardialgia 1994:20.): 1. cure: transference cure, electrocardiogram and regarding assay room check recovers normal.2. take a turn for the better: symptom alleviates, attack times reduces, and the intermission extends, and lab testing is improved.3. do not heal: cardinal symptom and electrocardiogram are without change.
4.2 observation index: observe serum estradiol (E 2) level (putting the method for exempting from, the operation of the test kit that provides by Tianjin Jiuding Medical Biological Engineering Co., Ltd of Sino-U.S.), respectively at before treatment and treat latter 3 months, 6 the end of month on an empty stomach 12h to phlebotomize detection.
4.3 results: treated through 6 months, cure 30 examples, and take a turn for the better 24 examples, and do not heal 6 examples, total effective rate 90.0%.Estradiol (E 2) level change see attached list.
Subordinate list estradiol (E 2) level change (pmol/L, )
Patient is E after 3 months 2level rises gradually, with the property (P < 0.01) that compares that there were significant differences before treatment.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention is described in further detail.But this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following embodiment, all technology realized based on content of the present invention all belong to scope of the present invention.
Embodiment 1
One treats Menopause uterine hemorrhage Chinese medicine composition, be by Semen Astragali Complanati 20 grams, Fluoritum 15 grams, Herba Pimpinellae thellungianae 18 grams, Radix Asparagi 12 grams, Radix Changii 15 grams, Herba Ecliptae 12 grams, Herb Gynostemmae Pentaphylli 20 grams, Radix Sophorae Tonkinensis 8 grams, Caulis Sargentodoxae 15 Ke, Herba Siegesbeckiae 25 grams, Myrrha (processed) 10 grams, Eupolyphaga Seu Steleophaga 8 grams conveniently Chinese medicine preparation technology make water decoction, everyone potion every day.
Embodiment 2
One treats Menopause uterine hemorrhage Chinese medicine composition, be by Semen Astragali Complanati 17 grams, Fluoritum 13 grams, Herba Pimpinellae thellungianae 16 grams, Radix Asparagi 11 grams, Radix Changii 13 grams, Herba Ecliptae 11 grams, Herb Gynostemmae Pentaphylli 17 grams, Radix Sophorae Tonkinensis 7 grams, Caulis Sargentodoxae 13 Ke, Herba Siegesbeckiae 22 grams, Myrrha (processed) 9 grams, Eupolyphaga Seu Steleophaga 7 grams conveniently Chinese medicine preparation technology make water decoction, everyone potion every day.
Embodiment 3
One treats Menopause uterine hemorrhage Chinese medicine composition, be by Semen Astragali Complanati 15 grams, Fluoritum 12 grams, Herba Pimpinellae thellungianae 15 grams, Radix Asparagi 10 grams, Radix Changii 12 grams, Herba Ecliptae 10 grams, Herb Gynostemmae Pentaphylli 15 grams, Radix Sophorae Tonkinensis 6 grams, Caulis Sargentodoxae 12 Ke, Herba Siegesbeckiae 20 grams, Myrrha (processed) 8 grams, Eupolyphaga Seu Steleophaga 6 grams conveniently Chinese medicine preparation technology make water decoction, everyone potion every day.
Embodiment 4
One treats Menopause uterine hemorrhage Chinese medicine composition, be by Semen Astragali Complanati 13 grams, Fluoritum 11 grams, Herba Pimpinellae thellungianae 14 grams, Radix Asparagi 9 grams, Radix Changii 11 grams, Herba Ecliptae 9 grams, Herb Gynostemmae Pentaphylli 13 grams, Radix Sophorae Tonkinensis 5 grams, Caulis Sargentodoxae 11 Ke, Herba Siegesbeckiae 18 grams, Myrrha (processed) 7 grams, Eupolyphaga Seu Steleophaga 5 grams conveniently Chinese medicine preparation technology make water decoction, everyone potion every day.
Embodiment 5
One treats Menopause uterine hemorrhage Chinese medicine composition, Semen Astragali Complanati 10 grams, Fluoritum 9 grams, Herba Pimpinellae thellungianae 12 grams, Radix Asparagi 8 grams, Radix Changii 9 grams, Herba Ecliptae 8 grams, Herb Gynostemmae Pentaphylli 10 grams, Radix Sophorae Tonkinensis 4 grams, Caulis Sargentodoxae 9 Ke, Herba Siegesbeckiae 15 grams, Myrrha (processed) 6 grams, Eupolyphaga Seu Steleophaga 4 grams conveniently Chinese medicine preparation technology make water decoction, everyone potion every day.

Claims (4)

1. treat a Menopause uterine hemorrhage Chinese medicine composition, it is characterized in that the medicament be made up of the crude drug of following mass ratio:
Semen Astragali Complanati 10 ~ 20 parts, Fluoritum 9 ~ 15 parts, Herba Pimpinellae thellungianae 12 ~ 18 parts, Radix Asparagi 8 ~ 12 parts, Radix Changii 9 ~ 15 parts, Herba Ecliptae 8 ~ 12 parts, Herb Gynostemmae Pentaphylli 10 ~ 20 parts, Radix Sophorae Tonkinensis 4 ~ 8 parts, Caulis Sargentodoxae 9 ~ 15 Fen, Herba Siegesbeckiae 15 ~ 25 parts, Myrrha (processed) 6 ~ 10 parts, Eupolyphaga Seu Steleophaga 4 ~ 8 parts.
2. treatment Menopause uterine hemorrhage Chinese medicine composition as claimed in claim 1, is characterized in that the medicament be made up of the crude drug of following mass ratio:
Semen Astragali Complanati 13 ~ 17 parts, Fluoritum 11 ~ 13 parts, Herba Pimpinellae thellungianae 14 ~ 16 parts, Radix Asparagi 9 ~ 11 parts, Radix Changii 11 ~ 13 parts, Herba Ecliptae 9 ~ 11 parts, Herb Gynostemmae Pentaphylli 13 ~ 17 parts, Radix Sophorae Tonkinensis 5 ~ 7 parts, Caulis Sargentodoxae 11 ~ 13 Fen, Herba Siegesbeckiae 18 ~ 22 parts, Myrrha (processed) 7 ~ 9 parts, Eupolyphaga Seu Steleophaga 5 ~ 7 parts.
3. treatment Menopause uterine hemorrhage Chinese medicine composition as claimed in claim 1, is characterized in that the medicament be made up of the crude drug of following mass ratio:
Semen Astragali Complanati 15 parts, Fluoritum 12 parts, Herba Pimpinellae thellungianae 15 parts, Radix Asparagi 10 parts, Radix Changii 12 parts, Herba Ecliptae 10 parts, Herb Gynostemmae Pentaphylli 15 parts, Radix Sophorae Tonkinensis 6 parts, Caulis Sargentodoxae 12 Fen, Herba Siegesbeckiae 20 parts, Myrrha (processed) 8 parts, Eupolyphaga Seu Steleophaga 6 parts.
4. treat the preparation method of Menopause uterine hemorrhage Chinese medicine composition as claimed in claim 1, it is characterized in that the Chinese medicinal components of described mass ratio to be prepared into water decoction, tablet, water-honeyed pill, capsule, powder, unguentum, oral liquid, granule.
CN201410713898.7A 2014-11-26 2014-11-26 It is a kind of to treat Menopause uterine hemorrhage Chinese medicine composition Expired - Fee Related CN104435635B (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101279075A (en) * 2007-04-05 2008-10-08 辽宁中医药大学附属医院 Medicament for curing coronary heart disease

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101279075A (en) * 2007-04-05 2008-10-08 辽宁中医药大学附属医院 Medicament for curing coronary heart disease

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* Cited by examiner, † Cited by third party
Title
张延武: "中医药防治绝经后冠心病的研究现状与展望", 《江西中医药》 *

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