CN104435624A - 柴石退热颗粒的提取方法和新用途 - Google Patents

柴石退热颗粒的提取方法和新用途 Download PDF

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CN104435624A
CN104435624A CN201410693654.7A CN201410693654A CN104435624A CN 104435624 A CN104435624 A CN 104435624A CN 201410693654 A CN201410693654 A CN 201410693654A CN 104435624 A CN104435624 A CN 104435624A
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李正梅
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Abstract

本发明提供了柴石退热颗粒的新用途，柴石退热颗粒由如下重量份数的原料制备得到：柴胡315g、黄芩315g、石膏630g、青蒿252g、板蓝根315g、金银花315g、大黄210g、蒲公英315g、知母210g、连翘210g，并公开了其制备方法。

Description

柴石退热颗粒的提取方法和新用途
技术领域
本发明涉及中药技术领域，具体涉及柴石退热颗粒的提取方法和新用途。
背景技术
肝脏是合成血浆蛋白的主要场所，除全部的血清白蛋白外，还有部分球蛋白也在肝脏合成。肝硬化时，肝脏功能的障碍加上营养不良等因素导致白蛋白合成障碍，肾脏损害使白蛋白丢失和消耗增多，从而使血清白蛋白含量下降。因此提高肝脏蛋白质含量的药物尤为重要。
发明内容
发明目的：为了解决上述问题，本发明的目的在于提供柴石退热颗粒的提取方法和新用途。
技术方案：本发明的目的是通过如下的方案实现的：
柴石退热颗粒在制备提高肝脏蛋白质合成药物中的应用。
柴石退热颗粒由如下重量份数的原料制备得到：柴胡315g、黄芩315g、石膏630g、青蒿252g、板蓝根315g、金银花315g、大黄210g、蒲公英315g、知母210g、连翘210g。
柴石退热颗粒的制备方法为：
(1)将大黄热浸三次，热浸温度为85-90℃，每次加8倍水量，每次半小时，合并浸出液，滤液备用；
(2)将生石膏粉碎成粉与柴胡、黄芩、青蒿、板蓝根、金银花、大黄、蒲公英、知母、连翘加水煎煮两次，第一次煎煮加15倍水，煎煮1.5小时，第二次煎煮加12倍水，煎煮1小时，合并煎煮液，滤过备用；
(3)将上述的浸出液和煎煮液合并，采用真空浓缩至相对密度为1.17-1.18/35℃的清膏；
(4)采用转速为23000-25000r/min的高速离心机进行分离将清膏除杂，然后喷雾干燥成干粉，按8g/包进行包装即成。
本发明中原料均符合中国药典标准。
有益效果：柴石退热颗粒能提高肝脏蛋白质合成。
具体实施方式
以下通过实施例形式，对本发明的上述内容再作进一步的详细说明，但不应将此理解为本发明上述主题的范围仅限于以下的实例，凡基于本发明上述内容所实现的技术均属于本发明的范围。
一、制备实施例
实施例1：称取柴胡315g、黄芩315g、石膏630g、青蒿252g、板蓝根315g、金银花315g、大黄210g、蒲公英315g、知母210g、连翘210g，将大黄热浸三次，热浸温度为85-90℃，每次加8倍水量，每次半小时，合并浸出液，滤液备用；将生石膏粉碎成粉与柴胡、黄芩、青蒿、板蓝根、金银花、大黄、蒲公英、知母、连翘加水煎煮两次，第一次煎煮加15倍水，煎煮1.5小时，第二次煎煮加12倍水，煎煮1小时，合并煎煮液，滤过备用；将上述的浸出液和煎煮液合并，采用真空浓缩至相对密度为1.17-1.18/35℃的清膏；采用转速为23000-25000r/min的高速离心机进行分离将清膏除杂，然后喷雾干燥成干粉，按8g/包进行包装即成。
对照实施例1：称取柴胡315g，加水煎煮两次，第一次煎煮加15倍水，煎煮1.5小时，第二次煎煮加12倍水，煎煮1小时，合并煎煮液，滤过备用；采用真空浓缩至相对密度为1.17-1.18/35℃的清膏；采用转速为23000-25000r/min的高速离心机进行分离将清膏除杂，然后喷雾干燥成干粉，按8g/包进行包装即成。
对照实施例2：称取黄芩315g，加水煎煮两次，第一次煎煮加15倍水，煎煮1.5小时，第二次煎煮加12倍水，煎煮1小时，合并煎煮液，滤过备用；采用真空浓缩至相对密度为1.17-1.18/35℃的清膏；采用转速为23000-25000r/min的高速离心机进行分离将清膏除杂，然后喷雾干燥成干粉，按8g/包进行包装即成。
上述喷雾干燥条件均为进风温度为110℃，出风温度为85℃，物料温度为85℃，雾化压力为0.3兆帕，喷雾速度为7.5ml/s。
二、效果实施例：柴石退热颗粒对大鼠肝脏蛋白质合成的研究
2.1实验动物：SD大鼠，南京医科大学实验动物中心，质量150g-180g。
2.2药品与试剂：柴石退热颗粒按上述制备实施例中实施例1方法制备得到，柴胡颗粒、黄芩颗粒分别按照对比实施例1和对比实施例2方法制备得到。总蛋白(TP)、白蛋白(ALB)、球蛋白(GLB)试剂盒购自南京建成生物试剂研究所。
2.3实验方法：
2.3.1分组及处置：50只大鼠适应性喂养1周后，按体重分层，随机分为5组，每组10只：空白组、实施例1高剂量组、实施例1低剂量组，对照实施例1组、对照实施例2组，均饲喂普通饲料，给予各组大鼠相应的药物干预，其中空白组按lmL/100g给予蒸馏水灌胃，按生药量计算，实施例1高剂量组给予20g/kg、实施例1低剂量组给予10g/kg，对照实施例1组给予20g/kg、对照实施例2组给予20g/kg，每日一次，直至10周结束，实验期间动物自由进食和进水，每周称取体重一次并观察动物进食、饮水、行为、精神状态、毛发及二便等情况。到期处死动物(处死前禁食12h)，腹主动脉采血，取动物肝脏，称重。
2.3.2指标检测与观察：实验结束后处死各组大鼠(处死前禁食12h)，腹主动脉采血，采用全自动生化分析仪测定总蛋白(TP)、白蛋白(ALB)、球蛋白(GLB)，各项指标检测结果见表1。
表1  柴石退热颗粒对大鼠肝脏蛋白质的含量影响(g/L)
组别 n TP ALB GLB
空白组 10 48.2±7.5 23.9±4.7 24.3±5.3
实施例1高剂量 10 67.7±9.4**△ 33.3±6.9**△ 33.6±8.1**△
实施例1低剂量 10 64.2±5.9**△ 31.7±7.2**△ 32.8±6.4**△
对比实施例1 10 49.6±3.4 24.2±6.8 25.4±9.4
对比实施例2 10 50.5±8.1 25.8±7.6 24.2±6.7
注:同空白组相比*p<0.05**<0.01；同对比实施例1或对比实施例2相比△<0.05△△<0.01
2.3.3结果表明：本发明实施例1高剂量组、实施例1低剂量组能提高大鼠的血清总蛋白TP(P<0.05)、白蛋白和球蛋白(P<0.01)水平均较空白组明显增高，与对比实施例1和对比实施例2有显著性差异(P<0.05)，说明用柴胡配伍黄芩、石膏、青蒿、板蓝根、金银花、大黄、蒲公英、知母、连翘，或者用黄芩配伍柴胡、石膏、青蒿、板蓝根、金银花、大黄、蒲公英、知母、连翘均取得意想不到的效果。

Claims (2)

1.柴石退热颗粒在提高肝脏蛋白质合成药物中的应用，其特征在于，柴石退热颗粒由如下重量份数的原料制备得到：柴胡315g、黄芩315g、石膏630g、青蒿252g、板蓝根315g、金银花315g、大黄210g、蒲公英315g、知母210g、连翘210g。
2.如权利要求1所述柴石退热颗粒在提高肝脏蛋白质合成药物中的应用，其特征在于，柴石退热颗粒的制备方法为：
(1)将大黄热浸三次，热浸温度为85-90℃，每次加8倍水量，每次半小时，合并浸出液，滤液备用；
(2)将生石膏粉碎成粉与柴胡、黄芩、青蒿、板蓝根、金银花、大黄、蒲公英、知母、连翘加水煎煮两次，第一次煎煮加15倍水，煎煮1.5小时，第二次煎煮加12倍水，煎煮1小时，合并煎煮液，滤过备用；
(3)将上述的浸出液和煎煮液合并，采用真空浓缩至相对密度为1.17-1.18/35℃的清膏；
(4)采用转速为23000-25000r/min的高速离心机进行分离将清膏除杂，然后喷雾干燥成干粉，按8g/包进行包装即成。
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CN105963641A (zh) * 2016-06-23 2016-09-28 李艳 治疗妇产科术后低热的清热颗粒
CN107019739A (zh) * 2016-08-30 2017-08-08 河南牧翔动物药业有限公司 一种鱼腥草芩蓝口服液及其制备方法和产品质量控制方法

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