CN104435491A - 一种用于治疗帕金森氏病的中药有效部位组合物及其制备方法 - Google Patents
一种用于治疗帕金森氏病的中药有效部位组合物及其制备方法 Download PDFInfo
- Publication number
- CN104435491A CN104435491A CN201410816789.8A CN201410816789A CN104435491A CN 104435491 A CN104435491 A CN 104435491A CN 201410816789 A CN201410816789 A CN 201410816789A CN 104435491 A CN104435491 A CN 104435491A
- Authority
- CN
- China
- Prior art keywords
- part composition
- chinese medicinal
- effective part
- preparation
- chinese medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8888—Pinellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/44—Ebenaceae (Ebony family), e.g. persimmon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/758—Zanthoxylum, e.g. pricklyash
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种治疗帕金森氏病的中药有效部位组合物及其制备方法。本发明所述中药有效部位组合物由半夏、竹黄、柿霜、黄皮、木通和椒目为原料,按照一定的重量份数制成。本发明所述中药有效部位组合物可以制备成治疗帕金森氏病的药物,具有补益肝肾、滋阴熄风、益气养血、活血化瘀、通络止颤的效果,可以显著治疗帕金森氏病,且具有无毒副作用,安全性高的优点。
Description
技术领域
本发明涉及中药组合物领域,具体涉及一种用于治疗帕金森氏病的中药有效部位组合物及其制备方法。
背景技术
帕金森氏病又称震颤麻痹,好发于中年以上男性。临床以震颤、肌肉强直和运动减少为特征,其确切病因至今不明。西医大多采用左旋多巴或抗胆碱能药物进行治疗,虽有一定疗效,但不少病人因副作用太大而被迫停药。久服的病人药效渐减,且不能控制病情的自然发展,因此,目前治疗难度较大。
发明内容
本发明的目的在于提供一种用于制备治疗帕金森氏病的中药有效部位组合物,该中药有效部位组合物可以快速有效的治疗帕金森氏病,具有治疗效果显著、安全性高、无毒副作用的优点。
本发明另一目的在于提供上述中药有效部位组合物的制备方法。
本发明上述目的通过以下技术方案予以实现:
根据中医经验,本病发生与年老体衰,七情内郁,饮食不当等有关,其病机为肝肾阴亏,气血两虚,痰热动风,气滞血瘀。
本发明所述治疗帕金森氏病的中药有效部位组合物由如下按照质量份数计的原料制成:半夏18、竹黄25、柿霜20、黄皮10、木通20和椒目7。
本发明治疗帕金森氏病的中药有效部位组合物适合加工的剂型为口服液。
本发明所述治疗帕金森氏病的中药有效部位组合物的制备方法包括如下步骤:
(1)将各中药组分粉碎,加入18倍量水,煎煮3次,每次煎煮1小时;过滤煎液后合并滤液,减压浓缩至相对浓度为1.2的膏,加乙醇,使其含醇量为68%,静置过夜,回收乙醇,浓缩;
(2)将浓缩后的浓缩液按照常规制剂工艺加入适合的辅料,加工口服液。
与现有技术相比,本发明具有如下有益效果:
(1)本发明所述组合物具有补益肝肾、滋阴熄风、益气养血、活血化瘀、通络止颤的功效,经试验,可以快速治疗帕金森氏病。
(2)本发明组合物无毒副作用。
(3)本发明组合物的制备方法简单易行,得率高,有效保持了药物的有效成分。
具体实施方式
以下结合实施例来进一步解释本发明,但实施例并不对本发明做任何形式的限定。
实施例1
取半夏18g、竹黄25g、柿霜20g、黄皮10g、木通20g和椒目7g,粉碎至粗粉,加入18倍量水,煎煮3次,每次煎煮1小时;过滤煎液后合并滤液,减压浓缩至相对浓度为1.2的膏,加乙醇,使其含醇量为68%,静置过夜,回收乙醇,得到浓缩液1000ml,取单糖浆,加入上述浓缩液,并用枸橼酸调pH至5,加蒸馏水至5000ml,搅拌均匀,精滤后分装成15ml玻璃瓶中,包装得到口服液。
本品为棕色澄明液体,放置半年内不产生浑浊,pH约5,总固体9%左右。
实施例2
临床观察病人500例,病人均有明显的帕金森氏病临床症状并经临床医师确诊。
口服实施例1制得的口服液,每日2次,每次15ml。用药时间为30天。
30天后,使用实施例1所得口服液的患者统计结果见表1。
疗效标准:显效是指治疗后患者主要症状和体征基本消失,生活可以自理或参加部分工作,随访三年无复发;无效是治疗后症状和体征均无改善。
表1
例数 | 显效 | 无效 | 显效率(%) |
500 | 401 | 99 | 80.2 |
通过表1可知,实施例1得到的口服液在治疗帕金森氏病有特效。本发明中药制成口服液后,可以在30天内非常显著的治愈或缓解帕金森氏病疾病。
实施例3
使用实施例1制得的口服液给药ICR小鼠,体重20~25g,雌雄各半,连续给药90d。
经预试,实施例1制得的洗剂毒性很低,测不出LD50,故对小鼠进行一日最大给药量测定。最大给药量为150ml/d,90天后观察无一例中毒死亡,全部健康存活,由此证明本发明所述组合物制成的口服液对人体不会造成毒副作用。
Claims (4)
1.一种治疗帕金森氏病的中药有效部位组合物,其特征在于由如下按照质量份数计的原料制成:半夏18、竹黄25、柿霜20、黄皮10、木通20和椒目7。
2.根据权利要求1所述的治疗帕金森氏病的中药有效部位组合物,其特征在于所述中药有效部位组合物制成口服液。
3.权利要求1或2所述治疗帕金森氏病的中药有效部位组合物的制备方法,其特征在于包括如下步骤:
(1)将各中药组分粉碎,加入18倍量水,煎煮3次,每次煎煮1小时;过滤煎液后合并滤液,减压浓缩至相对浓度为1.2的膏,加乙醇,使其含醇量为68%,静置过夜,回收乙醇,浓缩;
(2)将浓缩后的浓缩液按照常规制剂工艺加入适合的辅料,加工口服液。
4.权利要求1或2所述中药有效部位组合物的应用,其特征在于所述中药有效部位组合物用于制备治疗帕金森氏病的药物。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410816789.8A CN104435491A (zh) | 2014-12-25 | 2014-12-25 | 一种用于治疗帕金森氏病的中药有效部位组合物及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410816789.8A CN104435491A (zh) | 2014-12-25 | 2014-12-25 | 一种用于治疗帕金森氏病的中药有效部位组合物及其制备方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN104435491A true CN104435491A (zh) | 2015-03-25 |
Family
ID=52882752
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410816789.8A Pending CN104435491A (zh) | 2014-12-25 | 2014-12-25 | 一种用于治疗帕金森氏病的中药有效部位组合物及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN104435491A (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10821148B2 (en) | 2016-01-26 | 2020-11-03 | Industrial Technology Research Institute | Pharmaceutical composition for treating or alleviating an autoimmune disease and/or complication thereof and/or nephritis and method for treating or alleviating an autoimmune disease and/or complication thereof and/or nephritis |
-
2014
- 2014-12-25 CN CN201410816789.8A patent/CN104435491A/zh active Pending
Non-Patent Citations (2)
Title |
---|
刘健美等主编: "《中医内科学》", 31 July 2010, 中国中医药出版社 * |
谢阳谷主编: "《北京农村中医临床适宜技术》", 30 November 2005, 新华出版社 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10821148B2 (en) | 2016-01-26 | 2020-11-03 | Industrial Technology Research Institute | Pharmaceutical composition for treating or alleviating an autoimmune disease and/or complication thereof and/or nephritis and method for treating or alleviating an autoimmune disease and/or complication thereof and/or nephritis |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102058673A (zh) | 一种祛风除湿的中药组合物及其制备方法 | |
CN104435491A (zh) | 一种用于治疗帕金森氏病的中药有效部位组合物及其制备方法 | |
CN103239646B (zh) | 一种用于治疗白癜风的中药有效部位组合物及其制备方法 | |
CN103432204B (zh) | 一种用于治疗精神分裂症的中药有效部位组合物及其制备方法 | |
CN102846928A (zh) | 一种治疗冠心病的中药方 | |
CN103610944A (zh) | 一种活血化瘀酒 | |
CN103565986B (zh) | 一种用于治疗雷诺病的中药组合物及其制备方法 | |
CN103239543B (zh) | 一种用于治疗胃下垂的中药有效部位组合物及其制备方法 | |
CN103341100A (zh) | 一种活血止痛抗炎消肿的药酒 | |
CN103239571B (zh) | 一种用于治疗斑秃的中药有效部位组合物及其制备方法 | |
CN102772762B (zh) | 一种治疗皮肤病的中药有效部位组合物及其制备方法 | |
CN103239605B (zh) | 一种用于治疗骨质增生的中药有效部位组合物及其制备方法 | |
CN103432333B (zh) | 一种治疗甲状腺机能减退症的中药有效部位组合物 | |
CN102302583B (zh) | 一种消肿止痛的药物组合物 | |
CN103417900B (zh) | 一种用于治疗神经衰弱的中药有效部位组合物及其制备方法 | |
CN104524382A (zh) | 一种用于治疗高脂血症的中药有效部位组合物及其制备方法 | |
CN103432212A (zh) | 一种用于治疗坐骨神经痛的中药有效部位组合物及其制备方法 | |
CN104435646A (zh) | 一种用于治疗三叉神经痛的中药有效部位组合物及其制备方法 | |
CN105030983A (zh) | 一种治疗湿疹的外用中药 | |
CN103446433A (zh) | 一种用于去除口腔异味的中药有效部位组合物及其制备方法 | |
CN103463170B (zh) | 一种用于治疗骨质增生的中药有效部位组合物及其制备方法 | |
Gerush et al. | Investigation of the hepatoprotective properties of “Phytovenol” capsules on the model of medicamentous hepatitis in rats | |
CN104547540A (zh) | 一种治疗放化疗引起的白细胞减少、免疫功能低下药物组合物及其口服冲剂的制备方法 | |
CN103432397B (zh) | 一种治疗血栓闭塞性脉管炎的中药有效部位组合物 | |
CN103239671B (zh) | 一种用于治疗更年期综合征的中药有效部位组合物及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
WD01 | Invention patent application deemed withdrawn after publication | ||
WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150325 |