CN104435486A - Use of traditional Chinese medicine preparation in preparation of medicine for treating varicose vein of lower limb - Google Patents

Use of traditional Chinese medicine preparation in preparation of medicine for treating varicose vein of lower limb Download PDF

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Publication number
CN104435486A
CN104435486A CN201410739506.4A CN201410739506A CN104435486A CN 104435486 A CN104435486 A CN 104435486A CN 201410739506 A CN201410739506 A CN 201410739506A CN 104435486 A CN104435486 A CN 104435486A
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parts
chinese medicine
medicine preparation
preparation
radix
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邓凤桂
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GUANGDONG JUZHICHENG TECHNOLOGY Co Ltd
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GUANGDONG JUZHICHENG TECHNOLOGY Co Ltd
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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Abstract

The invention belongs to the field of traditional Chinese medicines and relates to use of a traditional Chinese medicine preparation in preparation of a medicine for treating varicose vein of lower limb. Aiming at the defect in the prior art that existing chemotherapeutic drug for varicose vein of lower limb is relatively great in hepatotoxicity and not excellent in curative effect, the invention provides the traditional Chinese medicine preparation for treating or preventing varicose vein of lower limb. The traditional Chinese medicine preparation comprises the following components in parts by weight: 9-51 parts of pseudo-ginseng, 9-21 parts of fructus forsythiae, 4-21 parts of pinellia ternata, 4-16 parts of cortex moutan, 4-11 parts of mangnolia officinalis, 4-16 parts of corydalis tubers, 4-16 parts of astragalus membranaceus, 1-12 parts of poria cocos, 4-16 parts of mint, 8-16 parts of bighead atractylodes rhizome, 8-16 parts of herb of herba cirsii, 4-16 parts of semen cuscutae, 0.1-10 parts of radix paeoniae alba, 5-16 parts of eucommia ulmoides, 5-10 parts of flos carthami and 9-16 parts of liquorice. The traditional Chinese medicine preparation provided by the invention has a very good treatment effect in treating or preventing varicose vein of lower limb, is low in side effects, and has a remarkable clinical promotional value.

Description

A kind of Chinese medicine preparation is for the preparation of the purposes for the treatment of varicose veins of the lower extremity medicine
Technical field
The invention belongs to field of medicaments, be specifically related to the purposes of a kind of Chinese medicine preparation for the preparation for the treatment of varicose veins of the lower extremity medicine.
Background technology
Varicosis refers to that the vein caused is tortuous, expansion due to factors such as blood stasis, vein tube wall weaknesses.All can there is varicose in the vein at the multiple position of health, such as hemorrhoid are exactly a kind of varicosis in fact, clinical visible esophagus fundus ventricularis varication, varicocele and abdominal wall varicosis etc. in addition.The position that varicosis the most often occurs is at lower limb.It is emphasized that varicosis itself may be the secondary manifestation of other pathological changes, as inaccessible in caval vein etc., answer positive treatment protopathy.
Cause the reason of varicose veins of the lower extremity a lot, the most common is the varicose of pure superficial veins of lower limb, and its Etiological is a burst functional defect for saphena valve.Another Important cause of disease sees Primary Deep Venous Valvular incompetence of Lower Limb (PDVI), and because it often merges great saphenous vein valve insufficiency, multilist reveals the tortuous expansion of Superficial veins.In addition, because Deep venou backflow is not smooth, there is the tortuous expansion of superficial vein compensatory in syndrome after deep venous thrombosis of lower limbs; Lower limb arteriovenous fistula, Klippel-Trenaunay syndrome also can have superficial veins of lower limb varicose to show; Postcava backflow obstruction, as Bgudd-Chiari Syndrome, also can cause varicose veins of the lower extremity.
The Therapeutic Method such as varicose veins of the lower extremity wears stretch socks, injection of sclerosing agent, operation divest, Deep venous valve malfunction, can make communicating branch ligation etc. under valve repair and chamber mirror.Varicose veins of the lower extremity also may point out other diseases to exist, and needs Cure the Primary Disease; If Deep venou backflow is not smooth, then surgical procedure superficial vein more should be careful.The history of Chinese medicine varicose veins of the lower extremity is of long standing and well established, and as an importance of modern diseases Comprehensive Treatment, more and more receives publicity in recent years.But the Chinese medicine of current clinical middle the use then comparatively slow or uncertain therapeutic efficacy of onset is cut, and clinical effectiveness is difficult to continue, and therefore can not obtain the effect of satisfied treatment.Research and develop a kind of effective medicine to varicose veins of the lower extremity to be of great practical significance.The present invention aims to provide a kind for the treatment of determined curative effect for varicose veins of the lower extremity, Chinese medicine preparation that toxic and side effects is little.
Summary of the invention
Large in order to overcome existing varicose veins of the lower extremity chemotherapeutic agent toxic and side effects, the prior art that varicose veins of the lower extremity therapeutic effect is difficult to continue is not enough, one of the object of the invention there is provided a kind of Chinese medicine preparation for the treatment of varicose veins of the lower extremity, this Chinese medicine preparation good effect, side effect is little, described Chinese medicine preparation is obtained by following raw material: Radix Notoginseng 9-51 part, connect and call 9-21 part together, Rhizoma Pinelliae 4-21 part, Cortex Moutan 4-16 part, Cortex Magnoliae Officinalis 4-11 part, Rhizoma Corydalis 4-16 part, Radix Astragali 4-16 part, Poria 1-12 part, Herba Menthae 4-16 part, Rhizoma Atractylodis Macrocephalae 8-16 part, Herba Cirsii 8-16 part, Semen Cuscutae 4-16 part, Radix Paeoniae Alba 0.1-10 part, Cortex Eucommiae 5-16 part, Flos Carthami 5-10 part, Radix Glycyrrhizae 9-16 part.
Chinese medicine preparation of the present invention is to remove long-pending numbness, dispersing wind and cold, wind-damp dispelling, bone and muscle strengthening for main standard on Chinese medicinal components is selected, and Chinese medicine preparation of the present invention has significant analgesia and activating blood circulation to dissipate blood stasis effect.The parts by weight of the present invention to above-mentioned all taste Chinese medicine carry out preferably, preferred condition be after drug matching uses medicine to the enhancing of varicose veins of the lower extremity therapeutic effect.As a preferred embodiment of the present invention, Chinese medicine preparation of the present invention obtains primarily of the raw material of following weight portion: Radix Notoginseng 30 parts, connects and calls 15 parts together, the Rhizoma Pinelliae 15 parts, Cortex Moutan 10 parts, Cortex Magnoliae Officinalis 8 parts, Rhizoma Corydalis 10 parts, the Radix Astragali 10 parts, 6 parts, Poria, Herba Menthae 10 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Herba Cirsii 12 parts, Semen Cuscutae 10 parts, the Radix Paeoniae Alba 5.5 parts, the Cortex Eucommiae 10 parts, 8 parts, Flos Carthami, 12 parts, Radix Glycyrrhizae.
Preferably, Chinese medicine preparation of the present invention also contains Rhizoma et radix valerianae 7 parts further, Herba Asari 4 parts, Radix Dipsaci 9 parts.Described three taste Chinese medicines add the activating blood circulation to dissipate blood stasis effect and analgesic activity that can strengthen Chinese medicine preparation.
Two of the object of the invention is to provide a kind of preparation method preparing Chinese medicine preparation described above, it mainly comprises following step: get the above-mentioned Chinese crude drug of recipe quantity and be broken into coarse powder, the alcoholic solution that volumetric concentration is 40% ~ 95% is added according to 4 ~ 9 times of coarse powder gross weight, reflux, extract, three times, return time is 2 ~ 5h, filters, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying; In order to express Chinese medicine preparation of the present invention better, Chinese medicine preparation of the present invention can be prepared into dosage form conventional clinically.Such as, the preparation such as powderous preparations, powder, pill, sublimed preparation, unguentum, granule, oral liquid, syrup, tablet, capsule.Preferably, Chinese medicine preparation of the present invention conveniently preparation technology be prepared into powder, water preparation, tablet or capsule.
The purposes of above-mentioned Chinese medicine preparation of the present invention in preparation treatment varicose veins of the lower extremity medicine, Be very effective, side effect is little.Pharmaceutical composition of the present invention, when treating varicose veins of the lower extremity, demonstrates significant analgesic activities and activating blood circulation to dissipate blood stasis activity.Test examples 19 of the present invention shows, and model group compares with normal control, the low cut index of whole blood, erythrocyte aggregation index, Casson viscosity and plasma viscosity all have and significantly increase ( p<0.05).Compare with model group, Chinese medicine preparation of the present invention each dosage group basic, normal, high all significantly or pole significantly reduce the low cut index of whole blood, erythrocyte aggregation index, Casson viscosity and plasma viscosity, reduction amplitude amount effect relationship, wherein high dose there were significant differences ( p<0.05).Under same experiment condition, positive control drug aescine group also reduces whole blood height cut index, the low cut index of whole blood, erythrocyte aggregation index, but its to the improvement effect of hemorheology index all not as good as Chinese medicine preparation of the present invention.Test examples 20 of the present invention shows, mice licks foot response latency time showing, compare with model group, after administration after 1h and 2h, the incubation period that the mice of each administration group of Chinese medicine preparation of the present invention adds foot reaction is all greater than model group, there is dose-dependence, and be significantly greater than the incubation period of high dose group model group ( p< 0.05).What illustrate that this Chinese medicine preparation of the present invention can extend that mice stimulates hot plate adds the sufficient response latency, has certain analgesic activity.Under same experiment condition, positive control drug aescine group ( p< 0.05) and pentoxifylline group (1h, p< 0.05; 2h, p< 0.01) also significant prolongation mice add the incubation period of foot reaction, have certain analgesic activity.And more estimable, containing plurality of active ingredients in Chinese medicine preparation of the present invention, many for target spot during varicose veins of the lower extremity treatment of infection, not easily produce drug resistance, be significantly better than existing clinical in widely used antibiotics.
In a word, Chinese medicine preparation of the present invention, in treatment varicose veins of the lower extremity, compared with prior art has following advantage:
1) compared with positive control drug aescine or pentoxifylline, Chinese medicine preparation composition of the present invention is not only more remarkable at ease pain, and also significantly positive drug is better than in activating blood circulation to dissipate blood stasis, this shows that the present composition has significant synergism in varicose veins of the lower extremity treatment, significantly can not only improve the symptom of varicose veins of the lower extremity, the development of varicose veins of the lower extremity can also be delayed, contribute to the recovery process of varicose veins of the lower extremity patient.
2) compared with the chemotherapeutic agent of Current therapeutic varicose veins of the lower extremity, Chinese medicine preparation of the present invention is natural pure Chinese medicinal preparation, untoward reaction and side effect significantly reduce, particularly it does not produce any destruction for intestinal mucosa, and Chinese medicine preparation effect of the present invention is comprehensive, medication effect is better, significantly improves the compliance of varicose veins of the lower extremity patient, and improves the quality of life of patient.
3) existing chemotherapeutic agent varicose veins of the lower extremity initial therapy effect still can, but all occur obvious drug resistance problem along with the prolongation for the treatment of time, its therapeutic effect for varicose veins of the lower extremity declines.Containing multi-medicament component in Chinese medicine preparation of the present invention, action target spot is numerous, efficiently solves the Commpensation And Adaptation of varicose veins of the lower extremity medicine, and it does not decline because treatment time extends to the therapeutic effect of varicose veins of the lower extremity.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
part I Chinese medicine preparation of the present invention, preparation and using method thereof
the powder of embodiment 1-6 Chinese medicine preparation
the powder prescription of table 1 Chinese medicine preparation of the present invention
Embodiment 1 preparation method: get each medical material in compositions, conveniently technique grinds to form powdery, cross 100 mesh sieves, little fire drying is for subsequent use, obtains powder.During use, directly take after mixing it with water with after water dissolution.Embodiment 2-6 preparation method is with embodiment 1.
the water preparation of embodiment 7-12 Chinese medicine preparation
the water preparation prescription of table 2 Chinese medicine preparation of the present invention
Embodiment 7 preparation method: get each medical material in prescription, conveniently decocting for Chinese herbal medicine technological operation, filtering medicinal residues and get final product.When this water preparation (or claiming decoction) is treated for varicose veins of the lower extremity, daily 2-3 time.Embodiment 8-12 preparation method and using method are with embodiment 7.
the tablets/capsules agent of embodiment 13-18 Chinese medicine preparation of the present invention
the tablets/capsules agent prescription of table 3 Chinese medicine preparation of the present invention
Embodiment 13 preparation technology: each traditional Chinese medicine powder getting recipe quantity is broken into coarse powder, adds according to 5 times of coarse powder gross weight the alcoholic solution that volumetric concentration is 80%, reflux, extract, three times, the each 3h of return time, filters, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying; By Chinese medical concrete drying, pulverize and make dried cream powder, add customary adjuvant components utilising prior art and be prepared into tablet or capsule.
Embodiment 14-18 preparation technology is with embodiment 13.
the pharmacodynamic study of Part II Chinese medicine preparation of the present invention
embodiment 19 Chinese medicine preparation of the present invention is to the improvement result of rat blood stasis models
Get healthy SD rat, body weight 200-220g, 88, male and female half and half, be divided into 8 groups at random by body weight: Normal group, model group, aescine group, pentoxifylline group and basic, normal, high group of Chinese medicine preparation of the present invention (obtaining by Chinese medicine preparation prescription described in embodiment 1 and preparation technology), often organize 11.Gastric infusion, successive administration 14 days, Normal group and model group are to 0.5%CMC, and all the other give corresponding medicine, and dosage is as shown in table 14.Administration the 13rd day, 14 days, except Normal group, all the other treated animals press 1mg/Kg subcutaneous injection adrenalin hydrochloride, 2 times/day, interval 4h, and after first time injection, animal is put into 15min in 4 DEG C of frozen water by 2h.Administration is got 4-5ml blood anticoagulant heparin on the 15th day and is measured blood rheology parameter, gets liver and to weigh conversion organ coefficient.
table 4 Chinese medicine preparation of the present invention on the impact of rat blood stasis models lectin from hemolymph ( ± s)
Note: compare with normal control, # p< 0.05, ## p< 0.01; Compare with model group, * p< 0.05, * p< 0.01
Result shows, and model group compares with normal control, the low cut index of whole blood, erythrocyte aggregation index, Casson viscosity and plasma viscosity all have and significantly increase ( p<0.05).Compare with model group, Chinese medicine preparation of the present invention each dosage group basic, normal, high all significantly or pole significantly reduce the low cut index of whole blood, erythrocyte aggregation index, Casson viscosity and plasma viscosity, reduction amplitude amount effect relationship, wherein high dose there were significant differences ( p<0.05).Under same experiment condition, positive control drug aescine group and pentoxifylline group also reduce whole blood height cut index, the low cut index of whole blood, erythrocyte aggregation index, but its to the improvement effect of hemorheology index all not as good as Chinese medicine preparation of the present invention.
embodiment 20 Chinese medicine preparation of the present invention affects mouse hot-plate analgesic
1 mouse hot-plate pain model makes
About body weight 22g female mice is placed on hot plate dolorimeter, screen qualified ♀ mice 80 (to lick metapedes time < 5 s or > 30 s to throw aside, scald for preventing foot, also deadline should be established, be generally 60s), the incubation period of metapedes reaction is added for threshold of pain index with mice, get 70 jennies, be divided into 7 groups, 10/group, i.e. model group, Tongqiao Biyan capsules, pentoxifylline group, Chinese medicine preparation of the present invention (obtaining by Chinese medicine preparation prescription described in embodiment 1 and preparation technology) low dose group, middle dosage group and high dose group.Each group is gastric infusion, and 1 times/day, dosage is as shown in table 10, and after successive administration 14d, after measuring last medicine, 60 min, 120 min add the time of foot reaction.
chinese medicine preparation of the present invention is on the impact of licking the foot response latency in mouse hot-plate analgesic experiment
table 5 mice lick foot response latency timetable ( ± s )
Note: compare with model group, * p< 0.05, * p< 0.01
Mice licks foot response latency time showing, compare with model group, after administration after 1h and 2h, the incubation period that the mice of each administration group of Chinese medicine preparation of the present invention adds foot reaction is all greater than model group, there is dose-dependence, and be significantly greater than the incubation period of high dose group model group ( p< 0.05).What illustrate that this Chinese medicine preparation of the present invention can extend that mice stimulates hot plate adds the sufficient response latency, has certain analgesic activity.Under same experiment condition, positive control drug aescine group ( p< 0.05) and pentoxifylline group (1h, p< 0.05; 2h, p< 0.01) also significant prolongation mice add the incubation period of foot reaction, have certain analgesic activity.

Claims (5)

1. Chinese medicine preparation is for the preparation of a purposes for treatment varicose veins of the lower extremity medicine, and it is characterized in that, described Chinese medicine preparation is obtained by the raw material of following weight portion:
Radix Notoginseng 9-51 part, connects and calls 9-21 part together, Rhizoma Pinelliae 4-21 part, Cortex Moutan 4-16 part, Cortex Magnoliae Officinalis 4-11 part, Rhizoma Corydalis 4-16 part, Radix Astragali 4-16 part, Poria 1-12 part, Herba Menthae 4-16 part, Rhizoma Atractylodis Macrocephalae 8-16 part, Herba Cirsii 8-16 part, Semen Cuscutae 4-16 part, Radix Paeoniae Alba 0.1-10 part, Cortex Eucommiae 5-16 part, Flos Carthami 5-10 part, Radix Glycyrrhizae 9-16 part.
2. purposes as claimed in claim 1, it is characterized in that, described Chinese medicine preparation is obtained by the raw material of following weight portion:
Radix Notoginseng 30 parts, connects and calls 15 parts together, the Rhizoma Pinelliae 15 parts, Cortex Moutan 10 parts, Cortex Magnoliae Officinalis 8 parts, Rhizoma Corydalis 10 parts, the Radix Astragali 10 parts, 6 parts, Poria, Herba Menthae 10 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Herba Cirsii 12 parts, Semen Cuscutae 10 parts, the Radix Paeoniae Alba 5.5 parts, the Cortex Eucommiae 10 parts, 8 parts, Flos Carthami, 12 parts, Radix Glycyrrhizae.
3. purposes as claimed in claim 2, it is characterized in that, described Chinese medicine preparation is also containing, for example the raw material of lower weight portion: Rhizoma et radix valerianae 7 parts, Herba Asari 4 parts and Radix Dipsaci 9 parts.
4. the purposes as described in as arbitrary in claim 1-3, it is characterized in that, described Chinese medicine preparation is powder, water preparation, tablet or capsule.
5. prepare the method for Chinese medicine preparation as claimed in claim 4 for one kind, it is characterized in that, comprise the following steps: get the above-mentioned Chinese crude drug of recipe quantity and be broken into coarse powder, add according to 4 ~ 9 times of coarse powder gross weight the alcoholic solution that volumetric concentration is 40% ~ 95%, reflux, extract, three times, return time is 2 ~ 5h, filter, filtrate recycling ethanol, cold filtration, wash with water, after drying, namely obtain Chinese medical concrete.
CN201410739506.4A 2014-12-08 2014-12-08 Use of traditional Chinese medicine preparation in preparation of medicine for treating varicose vein of lower limb Pending CN104435486A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1174054A (en) * 1997-05-07 1998-02-25 邓庆元 Medicine for removing thrombus and promoting blood circulation and its preparation
CN1583111A (en) * 2004-06-04 2005-02-23 刘俊清 Chinese medicine for varicose vein
CN101199642A (en) * 2007-12-19 2008-06-18 于殿安 Chinese medicine agent for treating lower limbs vein curves
CN101204543A (en) * 2007-12-17 2008-06-25 周轶 Medicament composite for varixoflowerlimb

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1174054A (en) * 1997-05-07 1998-02-25 邓庆元 Medicine for removing thrombus and promoting blood circulation and its preparation
CN1583111A (en) * 2004-06-04 2005-02-23 刘俊清 Chinese medicine for varicose vein
CN101204543A (en) * 2007-12-17 2008-06-25 周轶 Medicament composite for varixoflowerlimb
CN101199642A (en) * 2007-12-19 2008-06-18 于殿安 Chinese medicine agent for treating lower limbs vein curves

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* Cited by examiner, † Cited by third party
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陈柏楠等: "《周围血管疾病中西医诊疗学》", 30 September 1999 *

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Application publication date: 20150325