CN104435390A - Effective part composition of traditional Chinese medicines for treating epilepsy and preparation method of effective part composition - Google Patents

Effective part composition of traditional Chinese medicines for treating epilepsy and preparation method of effective part composition Download PDF

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Publication number
CN104435390A
CN104435390A CN201410816801.5A CN201410816801A CN104435390A CN 104435390 A CN104435390 A CN 104435390A CN 201410816801 A CN201410816801 A CN 201410816801A CN 104435390 A CN104435390 A CN 104435390A
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part composition
epilepsy
chinese medicinal
effective part
preparation
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张群
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Individual
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/41—Crassulaceae (Stonecrop family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/62—Nymphaeaceae (Water-lily family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/85—Verbenaceae (Verbena family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses an effective part composition of traditional Chinese medicines for treating epilepsy and a preparation method of the effective part composition. The effective part composition of the traditional Chinese medicines disclosed by the invention is prepared from the following raw materials in certain parts by weight: stringy stonecrop, giant knot weed, Taiwan beautyberry leaves, receptaculum nelumbinis, fructus sophorae and caesalpinia minax hance. The effective part composition of the traditional Chinese medicines disclosed by the invention can be prepared into medicines for treating epilepsy, and has the efficacies of tonifying the liver and kidneys, nourishing yin, extinguishing wind, reinforcing qi, nourishing blood, dispersing blood stasis and relieving dizziness, and has the advantages of significant curative effect on epilepsy, no toxic or side effect and high safety.

Description

A kind of Chinese medicinal effective-part composition being used for the treatment of epilepsy and preparation method thereof
Technical field
The present invention relates to Chinese medicine composition field, be specifically related to a kind of Chinese medicinal effective-part composition being used for the treatment of epilepsy and preparation method thereof.
Background technology
Epilepsy is a kind of nervous system common disease being performance with ictal of short duration brain function imbalance.According to domestic and international investigation, its prevalence is about 0.5%.Whether the definite pathogeny of primary disease is illustrated so far not yet completely, relevant with some factor according to the morbidity of epilepsy at present, is divided into constitutional and Secondary cases two class.Secondary cases is also called symptomatic epilepsy, has referred to the factor person that obviously cures the disease, as cerebrovascular disease, and craniocerebral injury, brain infections etc. can be also some systemic diseases, as cardiovascular disease, anoxia, the result of metabolic disease.Constitutional is also called idiopathy, refers to the person that not yet do not ascertain the reason at present.Inherited genetic factors occupies significant proportion in the not bright person of the cause of disease.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicinal effective-part composition for the preparation for the treatment of epilepsy, this Chinese medicinal effective-part composition can treat epilepsy fast and effectively, has the advantage that therapeutic effect is remarkable, safety is high, have no side effect.
Another object of the present invention is the preparation method providing above-mentioned Chinese medicinal effective-part composition.
Above-mentioned purpose of the present invention is achieved by the following technical programs:
The cause of disease of primary disease can be divided into the congenital day after tomorrow two kinds.The many fingers of congenital factors female pregnant time be subject to terrified, or disease in tire, misapply medicine, or the trouble of the original epilepsy of father and mother.It is unsuccessful that acquired disposition then comprises seven emotions, six climate exopathogens guest who is not a relative, falls to pounce on and beat.
The Chinese medicinal effective-part composition for the treatment of epilepsy of the present invention is made up of the following raw material according to mass fraction meter: Herba Sedi 22, Rhizoma Polygoni Cuspidati 20, Folium Callicarpae Formosanae 20, Receptaculum Nelumbinis 13, the Fructus Sophorae 11 and Semen Caesalpiniae Minacis 14.
The dosage form that the Chinese medicinal effective-part composition that the present invention treats epilepsy is applicable to processing is oral liquid.
The preparation method of the Chinese medicinal effective-part composition for the treatment of epilepsy of the present invention comprises the steps:
(1) each Chinese medicinal components is pulverized, add 18 times of water gagings, decoct 3 times, each decoction 1 hour; Merging filtrate after filtration decocting liquid, is evaporated to the cream that relative concentration is 1.13, adds ethanol, make its alcohol content be 68%, hold over night, reclaims ethanol, concentrated;
(2) by the concentrated solution after concentrated conveniently preparation process add applicable adjuvant, processing oral liquid.
Compared with prior art, the present invention has following beneficial effect:
(1) effect that compositions of the present invention has liver and kidney tonifying, nourishing YIN to subdue liver-wind, benefiting QI and nourishing blood, blood stasis dispelling relieve dizziness, high fever, infantile convulsions, epilepsy, etc., through test, can fast treating epilepsy.
(2) present composition has no side effect.
(3) preparation method of the present composition is simple, and yield is high, effectively maintains the effective ingredient of medicine.
Detailed description of the invention
Explain the present invention further below in conjunction with embodiment, but embodiment does not limit in any form to the present invention.
embodiment 1
Get Herba Sedi 22g, Rhizoma Polygoni Cuspidati 20g, Folium Callicarpae Formosanae 20g, Receptaculum Nelumbinis 13g, Fructus Sophorae 11g and Semen Caesalpiniae Minacis 14g, be crushed to coarse powder, add 18 times of water gagings, decoct 3 times, each decoction 1 hour; Merging filtrate after filtration decocting liquid, is evaporated to the cream that relative concentration is 1.13, adds ethanol, make its alcohol content be 68%, hold over night, reclaim ethanol, obtain concentrated solution 1000ml, get simple syrup, add above-mentioned concentrated solution, and adjust pH to 5 with citric acid, adding distil water is to 5000ml, stir, be distributed into after fine straining in 15ml vial, be packaged to be oral liquid.
This product is brown clear liquid, places in half a year and does not produce muddiness, pH about 5, total solid about 9%.
embodiment 2
Clinical observation patient 500 example, patient all has obvious epilepsy clinical symptoms and makes a definite diagnosis through clinicist.
The oral liquid that oral embodiment 1 is obtained, every day 2 times, each 15ml.Administration time is 30 days.
After 30 days, the patient census of embodiment 1 gained oral liquid is used to the results are shown in Table 1.
Criterion of therapeutical effect: effective refer to medication after, epilepsy control, or attack times in same period comparatively treatment before reduce more than 75%, during outbreak, symptom and persistent period all obviously alleviate and shorten, electroencephalogram improve, through following up a case by regular visits to 3 years, do not occur recur; Invalid is after medication, the number of times of epilepsy, and clinical symptoms etc. are all unchanged, even trend is serious.
Table 1
Number of cases Effective Invalid Obvious effective rate (%)
500 500 0 100
Known by table 1, the oral liquid that embodiment 1 obtains has specially good effect in treatment epilepsy.After oral liquid made by Chinese medicine of the present invention, can in 30 days highly significant healing or alleviate epileptic condition.
embodiment 3
Use the oral liquid administration ICR mice that embodiment 1 is obtained, body weight 20 ~ 25g, male and female half and half, successive administration 90d.
Through prerun, the lotion toxicity that embodiment 1 obtains is very low, does not measure LD50, therefore carries out maximum dosage-feeding mensuration on the one to mice.Maximum dosage-feeding is 150ml/d, observes none example and be poisoned to death after 90 days, and all healthy survival, proves that the oral liquid that compositions of the present invention is made can not cause toxic and side effects to human body thus.

Claims (4)

1. treat a Chinese medicinal effective-part composition for epilepsy, it is characterized in that being made up of the following raw material according to mass fraction meter: Herba Sedi 22, Rhizoma Polygoni Cuspidati 20, Folium Callicarpae Formosanae 20, Receptaculum Nelumbinis 13, the Fructus Sophorae 11 and Semen Caesalpiniae Minacis 14.
2. the Chinese medicinal effective-part composition for the treatment of epilepsy according to claim 1, is characterized in that described Chinese medicinal effective-part composition makes oral liquid.
3. treat the preparation method of the Chinese medicinal effective-part composition of epilepsy described in claim 1 or 2, it is characterized in that comprising the steps:
(1) each Chinese medicinal components is pulverized, add 18 times of water gagings, decoct 3 times, each decoction 1 hour; Merging filtrate after filtration decocting liquid, is evaporated to the cream that relative concentration is 1.13, adds ethanol, make its alcohol content be 68%, hold over night, reclaims ethanol, concentrated;
(2) by the concentrated solution after concentrated conveniently preparation process add applicable adjuvant, processing oral liquid.
4. the application of Chinese medicinal effective-part composition described in claim 1 or 2, is characterized in that the medicine of described Chinese medicinal effective-part composition for the preparation for the treatment of epilepsy.
CN201410816801.5A 2014-12-25 2014-12-25 Effective part composition of traditional Chinese medicines for treating epilepsy and preparation method of effective part composition Pending CN104435390A (en)

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Application Number Priority Date Filing Date Title
CN201410816801.5A CN104435390A (en) 2014-12-25 2014-12-25 Effective part composition of traditional Chinese medicines for treating epilepsy and preparation method of effective part composition

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201410816801.5A CN104435390A (en) 2014-12-25 2014-12-25 Effective part composition of traditional Chinese medicines for treating epilepsy and preparation method of effective part composition

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101732461A (en) * 2008-11-11 2010-06-16 中国嵩山少林禅武医慈善基金会有限公司 Composition for improving brain function and/or treating encephalopathy
CN102688461A (en) * 2011-03-23 2012-09-26 辽宁富东制药有限公司 Medicament treating epilepsy and its preparation method
CN103721170A (en) * 2012-10-11 2014-04-16 丁小燕 Tabasheer health care wine used for treating epilepsy
CN104042809A (en) * 2013-03-13 2014-09-17 刘志发 Traditional Chinese medicine composition for treating epilepsy

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101732461A (en) * 2008-11-11 2010-06-16 中国嵩山少林禅武医慈善基金会有限公司 Composition for improving brain function and/or treating encephalopathy
CN102688461A (en) * 2011-03-23 2012-09-26 辽宁富东制药有限公司 Medicament treating epilepsy and its preparation method
CN103721170A (en) * 2012-10-11 2014-04-16 丁小燕 Tabasheer health care wine used for treating epilepsy
CN104042809A (en) * 2013-03-13 2014-09-17 刘志发 Traditional Chinese medicine composition for treating epilepsy

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Application publication date: 20150325

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