CN104430302B - For preserving the normal temperature filling system of human organ - Google Patents
For preserving the normal temperature filling system of human organ Download PDFInfo
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- CN104430302B CN104430302B CN201410733749.7A CN201410733749A CN104430302B CN 104430302 B CN104430302 B CN 104430302B CN 201410733749 A CN201410733749 A CN 201410733749A CN 104430302 B CN104430302 B CN 104430302B
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- human organ
- filling system
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- normal temperature
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Abstract
The invention discloses a kind of normal temperature filling system, especially disclose a kind ofly for preserving the normal temperature filling system of human kidney, belong to Design for Medical Device manufacturing technology field. provide a kind of in the preservation process of transplant organ, can obviously reduce to be saved kidney functional lesion for preserving the normal temperature filling system of human organ. described normal temperature filling system comprises charge pump, human organ storage device and perfusion fluid monitoring assembly, the perfusion fluid input of described charge pump and perfusion fluid output penetrate after described human organ storage device, the perfusion body fluid output of the human organ of preserving with needs respectively and perfusion body fluid input are communicated with, described perfusion fluid monitoring assembly is serially connected on the perfusion fluid output of described charge pump, described human organ storage device also comprises thermoregulation mechanism, the environment temperature of described human organ storage device regulates by described thermoregulation mechanism, control.
Description
Technical field
The present invention relates to a kind of normal temperature filling system, especially relate to a kind of for preserving the normal temperature filling system of human organ, belong toIn Design for Medical Device manufacturing technology field.
Background technology
The shortage of donor resource is the topmost obstacle of restriction organ transplant, so, expand organ origin very urgent. Dead taxGive organ and mainly comprise that it is the main channel of Future in China organ origin that died kidney and liver organ damage are given, Ye Shi world organThe main flow of transplanting. Death is at present offered organs for transplant and is mainly divided into two kinds: the first is that DCD is heart death donations; The second is DBDBe brain death donations. Compare for device with DBD, DCD is longer for device experience warm ischemia time, and postoperative delay feature recovers to be called for short DGFDoubly, it is higher that primary nonfunctional is called for short PNF ratio to the high 2.5-4 of incidence, and long-term surviving is relatively poor. This causes transplanting doctorBe unwilling to use DCD for device, especially uncontrollable heart death donor, thus cause the potential loss for device of part.
At present died is damaged to the kidney organ that gives for death for device and the preserving type of liver organ mainly contains two kinds: firstPlant as freezing preservation; The second is continuous hypothermical perfusion. These two kinds of preserving types are all to adopt interpolation ice cube to fall low temperature environment,Reach and reduce for the anabolic passive preserving type of device. Thereby make these two kinds of preserving types all have two unavoidable hugeDefect: the firstth, refrigeration itself is for the damage of internal organs; The secondth, ischemical reperfusion injury. These damages may increase the weight of DCD and supplyThe functional lesion of device, causes the loss of organ, and then causes original source more nervous with regard in great shortage organ resource. Also meanwhile,Can increase the risk of organ transplant.
Summary of the invention
Technical problem to be solved by this invention is: provide a kind of and supply, in the preservation process of kidney, can obviously reduce to be saved in deathThe functional lesion of organ for preserving the normal temperature filling system of human organ.
For solving the problems of the technologies described above adopted technical scheme be: a kind of for preserving the normal temperature filling system of human organ, bagDraw together charge pump, human organ storage device and perfusion fluid monitoring assembly, perfusion fluid input and the perfusion liquid of described charge pumpBody output penetrates after described human organ storage device, the perfusion body fluid output of the human organ of preserving with needs respectively andPerfusion body fluid input is communicated with, and described perfusion fluid monitoring assembly is serially connected on the perfusion fluid output of described charge pump, instituteThe human organ storage device of stating also comprises thermoregulation mechanism, and the environment temperature of described human organ storage device is by describedThermoregulation mechanism regulates, controls.
Further: described normal temperature filling system also comprises human body simulation blood. reservoir, and described human body simulation blood is depositedReservoir is arranged in described human organ storage device, one end of described human body simulation blood. reservoir and the filling of described charge pumpFluid injection body input connects, and the other end is connected with the perfusion body fluid output that needs the human organ of preserving.
Further, in described human body simulation blood. reservoir, also store human body simulation blood, described human body simulation bloodElectrolyte concentration, acid-base value and the nutriment of liquid and the blood of people's body-internal-circulation adapt.
The invention has the beneficial effects as follows: by arranging on the human organ storage device described that a thermoregulation mechanism regulatesWith control the environment temperature of described human organ storage device, make in the environment temperature of described human organ storage device and human bodyTemperature adapts, and then on described normal temperature filling system, a human body simulation blood. reservoir is set, and at this human mouldIntend depositing the human body adapting with the blood of electrolyte concentration, acid-base value and nutriment and people's body-internal-circulation in blood. reservoirSimulate blood. Like this, just can make environment facies in whole normal temperature filling system and human body seemingly, thereby make to be poured the people of preservationBody organ, in the process of Perfusion preservation, remains in the environment similar to human body for a long time by the monitoring of perfusion fluid monitoring assembly,Reach and keep to greatest extent organ original function, obviously reduce to be saved the functional lesion object while of organ, right as much as possibleThe active reparation that the part that organ is damaged is organized.
Further, described normal temperature filling system also comprises oxygen supply membrane lung, and described oxygen supply membrane lung is serially connected in described charge pumpPerfusion fluid output and described perfusion fluid monitoring assembly between.
Further, described perfusion fluid monitoring assembly comprises liquid temperature sensor, hydrostatic sensor and flow sensor, instituteThe normal temperature filling system of stating also comprises the central processing unit that contains PLC control module, the perfusion that is serially connected in described charge pump of orderThe information control end of described liquid temperature sensor, hydrostatic sensor and flow sensor on liquid output, respectively with described central authoritiesThe PLC control module of processor connects.
Further, the information that is also provided with on described central processing unit is launched Wifi assembly automatically, passes by described liquid temperatureThe parameter of the perfusion liquid that sensor, hydrostatic sensor and flow sensor monitor, can launch Wifi automatically by described informationWhat assembly was wireless passes to outside corresponding receiving system.
The optimal way of such scheme is on described human organ storage device, to be provided with temperature sensor, described temperature biographyThe information control end of sensor is connected with the PLC control module of described central processing unit.
Further, the information control of described thermoregulation mechanism and the PLC control module of described central processing unit are connected.
Further, described thermoregulation mechanism is that the changes in temperature that are arranged on described human organ storage device madial wall regulate rowPipe.
Further, described charge pump is the pulse charge pump of simulation human heart.
Brief description of the drawings
Fig. 1 is the present invention for preserving the simplified structure schematic diagram of normal temperature filling system of human organ.
In figure, be labeled as: charge pump 1, human organ storage device 2, perfusion fluid monitoring assembly 3, human organ 4, temperatureGovernor motion 5, human body simulation blood. reservoir 6, human body simulation blood 7, oxygen supply membrane lung 8, liquid temperature sensor 9, hydraulic pressure passSensor 10, flow sensor 11, PLC control module 12, information are launched Wifi assembly 13, temperature sensor 14 automatically.
Detailed description of the invention
Be provided by the invention a kind of in the preservation process of transplant organ as shown in Figure 1, can obviously reduce to be saved the merit of organCan infringement for preserving the normal temperature filling system of human organ. Described normal temperature filling system comprises charge pump 1, human organStorage device 2 and perfusion fluid monitoring assembly 3, perfusion fluid input and the perfusion fluid output of described charge pump 1 penetrateAfter described human organ storage device 2, respectively with needs preserve human organ 4 perfusion body fluid output and perfusion body fluidInput is communicated with, and described perfusion fluid monitoring assembly 3 is serially connected on the perfusion fluid output of described charge pump 1, describedHuman organ storage device 2 also comprises thermoregulation mechanism 5, described in the environment temperature of described human organ storage device 2 is passed throughThermoregulation mechanism 5 regulate, control. By arranging a thermoregulation mechanism on the human organ storage device 2 described5 carry out the environment temperature of human organ storage device 2 described in regulation and control, make the environment temperature of described human organ storage device 2Degree adapts with the temperature in human body, and then on described normal temperature filling system, a human body simulation blood. reservoir 6 is set,And in this human body simulation blood. reservoir 6, deposit in and the blood of electrolyte concentration, acid-base value and nutriment and people's body-internal-circulationThe human body simulation blood 7 that liquid phase adapts to. Like this, just can make environment facies in whole normal temperature filling system and human body seemingly, therebyMake the human organ 4 that is poured preservation in the process of Perfusion preservation, keep for a long time by the monitoring of perfusion fluid monitoring assembly 3In the environment similar to human body, reach and keep to greatest extent organ original function, obviously reduce to be saved the function damage of organThe evil object while, the active reparation that the part as much as possible organ being damaged is organized.
In above-mentioned embodiment, in order to simulate to greatest extent the environment in human body, and monitor accurately at any time this simulated environmentSituation, described normal temperature filling system also comprises oxygen supply membrane lung 8, described oxygen supply membrane lung 8 is serially connected in the filling of described charge pump 1Between fluid injection body output and described perfusion fluid monitoring assembly 3; Described perfusion fluid monitoring assembly 3 comprises liquid temperature sensingDevice 9, hydrostatic sensor 10 and flow sensor 11, described normal temperature filling system also comprises and contains PLC control module 12Central processing unit, described liquid temperature sensor 9, hydraulic pressure on the perfusion fluid output that is serially connected in described charge pump 1 of order passThe information control end of sensor 10 and flow sensor 11, is connected with the PLC control module 12 of described central processing unit respectively; InstituteState the information control of thermoregulation mechanism 5 and the PLC control module 12 of described central processing unit is connected, and at the human body describedOn organ storage device 2, be provided with temperature sensor 14, make information control end and the described centre of described temperature sensor 14The PLC control module 12 of reason device connects; The pulse charge pump that described charge pump 1 is simulation human heart. Like this, pulse is filled withHeart in the similar human body of note pump, for filling system provides power; Lung in the similar human body of oxygen supply membrane lung 8 is human body simulation bloodLiquid 7 provides oxygen. Add liquid temperature sensor 9, hydrostatic sensor 10, flow sensor 11 and temperature sensor 14 with enteringCan monitor the environment of this filling system simulation, and central processing unit is adjusted at any time. And for by instant described various informationPass to user, the information that is also provided with on described central processing unit is launched Wifi assembly 13 automatically, by described liquid temperatureThe parameter of the perfusion liquid that sensor 9, hydrostatic sensor 10 and flow sensor 11 monitor, can be by described information certainlyWhat moving transmitting Wifi assembly 13 was wireless passes to outside corresponding receiving system.
And for the each parts that make the filling system described in the application use parts of the prior art to greatest extent, to utilize markStandardization is used and manufactures, and described thermoregulation mechanism 5 is for being arranged in the changes in temperature tune on described human organ storage device 2 madial wallsJoint comb.
Claims (7)
1. for preserving a normal temperature filling system for human organ, comprise charge pump (1), human organ storage device (2)With perfusion fluid monitoring assembly (3), the perfusion fluid input of described charge pump (1) and perfusion fluid output penetrate describedAfter human organ storage device (2), respectively with needs preserve human organ (4) perfusion body fluid output and perfusion body fluidInput is communicated with, and described perfusion fluid monitoring assembly (3) is serially connected on the perfusion fluid output of described charge pump (1),It is characterized in that: described human organ storage device (2) also comprises thermoregulation mechanism (5) described human organ storage dressThe environment temperature of putting (2) is regulated, is controlled by described thermoregulation mechanism (5),
Described normal temperature filling system also comprises human body simulation blood. reservoir (6), described human body simulation blood. reservoir (6)Be arranged in described human organ storage device (2) one end of described human body simulation blood. reservoir (6) and described perfusionThe perfusion fluid input of pump (1) connects, and the other end is connected with the perfusion body fluid output that needs the human organ (4) of preserving,
In described human body simulation blood. reservoir (6), also store human body simulation blood (7), described human body simulation blood(7) electrolyte concentration, acid-base value and nutriment and the blood of people's body-internal-circulation adapt,
Described thermoregulation mechanism (5) is for being arranged in the changes in temperature adjusting comb on described human organ storage device (2) madial wall.
2. according to claim 1 for preserving the normal temperature filling system of human organ, it is characterized in that: described is normalTemperature filling system also comprises oxygen supply membrane lung (8), and described oxygen supply membrane lung (8) is serially connected in the perfusion fluid of described charge pump (1)Between output and described perfusion fluid monitoring assembly (3).
3. according to claim 2 for preserving the normal temperature filling system of human organ, it is characterized in that: described fillingFluid injection body monitoring assembly (3) comprises liquid temperature sensor (9), hydrostatic sensor (10) and flow sensor (11), describedNormal temperature filling system also comprises the central processing unit that contains PLC control module (12), order be serially connected in described charge pump (1)Perfusion fluid output on the information of described liquid temperature sensor (9), hydrostatic sensor (10) and flow sensor (11)Control end, is connected with the PLC control module (12) of described central processing unit respectively.
4. according to claim 3 for preserving the normal temperature filling system of human organ, it is characterized in that: describedThe information that is also provided with on central processing unit is launched Wifi assembly (13) automatically, by described liquid temperature sensor (9), hydraulic sensingThe parameter of the perfusion liquid that device (10) and flow sensor (11) monitor, can launch Wifi group automatically by described informationWhat part (13) was wireless passes to outside corresponding receiving system.
5. according to claim 3 for preserving the normal temperature filling system of human organ, it is characterized in that: describedOn human organ storage device (2), be provided with temperature sensor (14), the information control end of described temperature sensor (14) withThe PLC control module (12) of described central processing unit connects.
6. according to claim 5 for preserving the normal temperature filling system of human organ, it is characterized in that: described temperatureThe information control of governor motion (5) is connected with the PLC control module (12) of described central processing unit.
7. according to claim 1 for preserving the normal temperature filling system of human organ, it is characterized in that: described fillingNote pump (1) is the pulse charge pump of simulation human heart.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410733749.7A CN104430302B (en) | 2014-12-04 | 2014-12-04 | For preserving the normal temperature filling system of human organ |
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| CN201410733749.7A CN104430302B (en) | 2014-12-04 | 2014-12-04 | For preserving the normal temperature filling system of human organ |
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| CN104430302A CN104430302A (en) | 2015-03-25 |
| CN104430302B true CN104430302B (en) | 2016-05-18 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020192511A1 (en) * | 2019-03-22 | 2020-10-01 | 天一阁医疗科技(广州)有限公司 | Organ perfusion teaching and training system |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104739520B (en) * | 2015-04-20 | 2017-06-27 | 匡仁锐 | The control method of medical charging pump and the system using the method |
| CN105165801B (en) * | 2015-08-28 | 2018-08-14 | 天津市第一中心医院 | A kind of portable liver room temperature save set |
| CN109619091B (en) * | 2019-02-01 | 2024-03-22 | 陈建轩 | Kidney perfusion device |
| CN110250157A (en) * | 2019-05-07 | 2019-09-20 | 四川大学华西医院 | Process for robot kidney transplantation operation stores cooling device |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2510080B (en) * | 2011-11-10 | 2017-09-27 | Organox Ltd | Organ perfusion systems |
| CN202999168U (en) * | 2012-12-18 | 2013-06-19 | 武汉大学 | Isolated kidney continuous perfusion preservation device |
| CN102986649B (en) * | 2012-12-18 | 2014-07-16 | 武汉大学 | In vitro continuous filling device used for autologous liver transplantation |
| CN103609551A (en) * | 2013-12-02 | 2014-03-05 | 尚文俊 | Organ transfer device |
| CN103719075B (en) * | 2014-01-14 | 2015-01-28 | 吕凌 | Isolated organ preserving device and preserving method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2020192511A1 (en) * | 2019-03-22 | 2020-10-01 | 天一阁医疗科技(广州)有限公司 | Organ perfusion teaching and training system |
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