CN107114358B - liver machine perfusion control system, method and device - Google Patents
liver machine perfusion control system, method and device Download PDFInfo
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- CN107114358B CN107114358B CN201710447818.1A CN201710447818A CN107114358B CN 107114358 B CN107114358 B CN 107114358B CN 201710447818 A CN201710447818 A CN 201710447818A CN 107114358 B CN107114358 B CN 107114358B
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- 210000004185 liver Anatomy 0.000 title claims abstract description 138
- 230000010412 perfusion Effects 0.000 title claims abstract description 119
- 238000000034 method Methods 0.000 title claims abstract description 36
- 239000008280 blood Substances 0.000 claims abstract description 157
- 210000004369 blood Anatomy 0.000 claims abstract description 157
- 230000036772 blood pressure Effects 0.000 claims abstract description 149
- 230000036770 blood supply Effects 0.000 claims abstract description 131
- 210000003240 portal vein Anatomy 0.000 claims abstract description 64
- 241000415078 Anemone hepatica Species 0.000 claims abstract description 57
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- 238000012545 processing Methods 0.000 claims abstract description 47
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- 230000002440 hepatic effect Effects 0.000 claims abstract description 16
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0236—Mechanical aspects
- A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
- A01N1/0247—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components for perfusion, i.e. for circulating fluid through organs, blood vessels or other living parts
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Abstract
The present invention relates to a kind of liver machine perfusion control device, method and apparatus, including connection arteria hepatica, the first centrifugal blood pump subsystem and connection portal vein, the second centrifugal blood pump subsystem that constant type blood supply is carried out to portal vein to arteria hepatica progress pulsation type blood supply.The present invention carries out pulsation type blood pressure data processing mode to hepatic arterial infusion pipeline blood pressure, and constant type blood pressure data processing mode is carried out to portal vein perfusion pipeline blood pressure, and using blood pressure as main control parameter, auxiliary monitoring parameter is used as using blood flow.And then the Supply form close with true heart beating blood supply is produced to arteria hepatica respectively, the Supply form for stablizing blood supply in human body close to true portal vein is produced to portal vein.Liver machine perfusion control device of the present invention, method and apparatus help to improve reparation and the preservation effect to edge donor organ such as liver, reduce liver reperfusion injury risk.
Description
Technical field
The present invention relates to machine perfusion technical field, more particularly to a kind of liver machine perfusion control device, method with
And device.
Background technology
Machine perfusion is a kind of mode for preserving organ, transporting, and native blood vessel is connected to organ by organ after being acquired
Machine perfusion system, system preserves and transports the stage by perfusate Continuous Perfusion to isolated organ in organ, while supplies in vitro
Organ oxygen and nutrients etc..
Most liver perfusion system uses extracorporeal membrane oxygenation (ECMO, extracorporeal membrane
Oxygenation) the system reform, is irrigated liver.Traditional ECMO systems are mainly irrigated blood supply using occlusion pump,
Sufficient power can be provided by occlusion pump blood supply to reach the blood flow and blood pressure needed for organ (heart).But liver supplies
There is very big difference in blood, such as blood pressure, blood flow and blood vessel thickness, therefore, the liver based on occlusion pump are filled with heart blood supply
Note mode is improper to apply to liver blood supply.
In practice, inventor has found conventional art, and at least there are the following problems：With stream in traditional ECMO systems
Measure and be adapted to heart blood supply for leading blood pump control method, and liver and heart have architectural difference, there are arteria hepatica and door for liver
Two, vein is into blood vessel, and arteria hepatica and pylic blood parameters are inconsistent.
The content of the invention
Based on this, it is necessary to the problem of being unfavorable for liver blood supply for the machine perfusion in conventional art, there is provided a kind of liver
Dirty machine perfusion control device, method and device.
To achieve these goals, on the one hand, an embodiment of the present invention provides a kind of liver machine perfusion control device, bag
Include connection arteria hepatica, the first centrifugal blood pump subsystem that pulsation type blood supply is carried out to arteria hepatica and connection portal vein, quiet on the door
Arteries and veins carries out the second centrifugal blood pump subsystem of constant type blood supply.
First centrifugal blood pump subsystem includes the first master controller, and be connected respectively with the first main controller circuit
First centrifugal blood pump and the first invasive pressure detector.First master controller is according to the first goal-selling pressure value, generation first
Initial motor rotary speed instruction, the first centrifugal blood pump carry out initial blood supply according to the first initial motor rotary speed instruction to arteria hepatica.The
One invasive pressure detector gathers hepatic arterial first pressure value,.First master controller is chosen in default beat cycles
Some first pressure values, pulsation type blood pressure data processing is carried out to each first pressure value, is obtained first real-time in beat cycles
Pressure value；First master controller generates first turn according to the first goal-selling pressure value, the first real-time pressure value and beat cycles
Speed instruction, the first centrifugal blood pump adjust rotating speed according to the first rotary speed instruction, and blood supply is carried out to arteria hepatica.
Second centrifugal blood pump subsystem includes the second master controller, and connects respectively with second main controller circuit
The second centrifugal blood pump connect and the second invasive pressure detector.Second master controller is obtained according to the second goal-selling blood pressure, raw
Into the second initial motor rotary speed instruction, initial blood supply is carried out to portal vein, the second invasive pressure detector collection pylic the
Two pressure values.Second master controller chooses some second pressure values in predetermined period, each second pressure value is carried out permanent
The processing of fixed pattern blood pressure data, obtains the second actual blood pressure value in predetermined period.Second master controller is according to the second goal-selling
Pressure value and the second real-time pressure value, produce the second rotary speed instruction, and the second centrifugal blood pump adjusts rotating speed according to the second rotary speed instruction,
Blood supply is carried out to portal vein.
On the other hand, the embodiment of the present invention additionally provides a kind of liver machine perfusion control method, including step：
First master controller initially supplies arteria hepatica according to the first goal-selling pressure value, the first centrifugal blood pump of driving
Blood；
First master controller choose the first invasive pressure detector collection, in default beat cycles some first
Pressure value, pulsation type blood pressure data processing is carried out to each first pressure value, obtains the first real-time blood pressure in default beat cycles
Value；
First master controller is according to the first goal-selling pressure value, the first real-time pressure value and default beat cycles, driving
First centrifugal blood pump adjusts rotating speed, and blood supply is carried out to arteria hepatica；
Second master controller initially supplies portal vein according to the second goal-selling pressure value, the second centrifugal blood pump of driving
Blood；
Second main controller chooses some second blood pressures that the second invasive pressure detector gathers, in predetermined period
Value, and constant type blood pressure data processing is carried out to each second pressure value, obtain the second real-time pressure value in predetermined period；
Second master controller drives the second centrifugal blood pump tune according to the second goal-selling pressure value and the second real-time pressure value
Turn over speed, blood supply is carried out to portal vein.
On the other hand, the embodiment of the present invention additionally provides a kind of liver machine perfusion control device, including：
First control unit, for being carried out according to the first goal-selling pressure value, the first centrifugal blood pump of driving to arteria hepatica
Initial blood supply；Some first pressure values that the first invasive pressure detector gathers, in default beat cycles are chosen, to each
First pressure value carries out pulsation type blood pressure data processing, obtains the first real-time pressure value in default beat cycles；According to first
Goal-selling pressure value, the first real-time pressure value and default beat cycles, driving the first centrifugal blood pump root adjustment rotating speed, move liver
Arteries and veins carries out blood supply；
Second control unit, for being carried out according to the second goal-selling pressure value, the second centrifugal blood pump of driving to portal vein
Initial blood supply；Choose the second invasive pressure detector collection, some second pressure values in predetermined period, and to each the
Two pressure values carry out constant type blood pressure data processing, obtain the second real-time pressure value in predetermined period；According to the second default mesh
Pressure value and the second real-time pressure value are marked, driving the second centrifugal blood pump adjustment rotating speed, blood supply is carried out to portal vein.
The invention has the advantages that and beneficial effect：
Liver machine perfusion control device of the present invention, method and device, according to the arteria hepatica of liver and two, portal vein into
The difference of blood vessel, using the arteriopalmus mode of simulation human body, sets up two independent centrifugal blood pump blood supply systems, right respectively
Arteria hepatica carries out pulsation type perfusion blood supply, and constant type perfusion blood supply is carried out to portal vein.Further, the present invention fills arteria hepatica
The blood pressure data noted in pipeline obtains real-time pressure value using pulsation type blood pressure data processing mode, in portal vein perfusion pipeline
Blood pressure data real-time pressure value is obtained using constant type blood pressure data processing mode.In combination with goal-selling pressure value, reality
When pressure value and setting cycle, using the blood supply blood pressure in priming line as main control parameter, adjustment centrifugal blood pump rotating speed is given birth to
Into corresponding blood supply blood pressure, and then the blood supply close with true heart beating is produced to arteria hepatica, portal vein is produced close to true
The blood supply that portal vein is stablized in human body.The liver machine perfusion control device of the present invention, method and device, realize and liver are moved
Low control when high during arteries and veins priming line blood pressure, forms the external blood supply state similar to true heart blood supply, reaches stable
Pulse frequency, systolic pressure, diastolic pressure and pulse pressure difference；Control to portal vein perfusion pipeline, is realized closer to true portal vein in human body
In Supply form.The present invention helps to improve the reparation and preservation effect to edge donor organ such as liver, reduces liver again
Perfusion injury risk.
Brief description of the drawings
Fig. 1 is the system structure diagram of liver machine perfusion control device embodiment 1；
Fig. 2 is that pulsation type blood pressure data processing mode waveform is illustrated in liver machine perfusion control device embodiment 1
Figure；Fig. 3 is constant type blood pressure data processing mode waveform diagram in liver perfusion control device embodiment 1；
Fig. 4 is blood flow parameter auxiliary monitoring flow diagram in liver machine perfusion control device embodiment 1；
Fig. 5 is that the first centrifugal blood pump subsystem pressure of liver machine perfusion control method embodiment 1 is main contral parameter
Idiographic flow schematic diagram；
Fig. 6 is that the second centrifugal blood pump subsystem pressure of liver machine perfusion control method embodiment 1 is main contral parameter
Idiographic flow schematic diagram；
Fig. 7 is the idiographic flow schematic diagram of liver machine perfusion control method embodiment 1；
Fig. 8 is that the blood flow of liver machine perfusion control method embodiment 1 is shown as the idiographic flow of auxiliary monitoring parameter
It is intended to；
Fig. 9 is the idiographic flow schematic diagram of the blood pressure data processing method of liver machine perfusion control method；
Figure 10 is the structure diagram of liver machine perfusion control device embodiment 1.
Embodiment
For the ease of understanding the present invention, the present invention is described more fully below with reference to relevant drawings.In attached drawing
Give the preferred embodiment of the present invention.But the present invention can realize in many different forms, however it is not limited to this paper institutes
The embodiment of description.On the contrary, the purpose for providing these embodiments is made to the disclosure more thorough and comprehensive.
Unless otherwise defined, all of technologies and scientific terms used here by the article is with belonging to technical field of the invention
The normally understood implication of technical staff is identical.Term used in the description of the invention herein is intended merely to description tool
The purpose of the embodiment of body, it is not intended that in the limitation present invention.Term as used herein " and/or " include one or more phases
The arbitrary and all combination of the Listed Items of pass.
It is the system structure diagram of liver machine perfusion control device embodiment 1, as shown in Figure 1, this reality referring to Fig. 1
The liver machine perfusion control device in example is applied, including connects arteria hepatica respectively, for carrying out pulsation type blood supply to arteria hepatica
First centrifugal blood pump subsystem 12 and connection portal vein, carry out portal vein the second centrifugal blood pump subsystem of constant type blood supply
System 10.
First centrifugal blood pump subsystem 12 includes the first master controller 129, and electric with the first master controller 129 respectively
The first centrifugal blood pump 127 and the first invasive pressure detector 121 of road connection；First master controller 129 is according to the first default mesh
Pressure value is marked, generates the first initial motor rotary speed instruction, the first centrifugal blood pump 127 is right according to the first initial motor rotary speed instruction
Arteria hepatica carries out initial blood supply.The first pressure value of arteria hepatica that first invasive pressure detector 121 gathers, the first master controller
129 choose some first pressure values in default beat cycles, and each first pressure value is carried out at pulsation type blood pressure data
Reason, obtains the first real-time pressure value in default beat cycles.First master controller 129 is according to the first goal-selling blood pressure
Value, the first real-time pressure value and beat cycles, generate the first rotary speed instruction, the first centrifugal blood pump 127 is according to the first rotary speed instruction
Rotating speed is adjusted, blood supply is carried out to arteria hepatica.
Specifically, beat cycles are the default time for simulating human body artery tube wall expansion and contraction.In the present embodiment
Liver machine perfusion control device by pulsation type Supply form, according to the first goal-selling pressure value, the first invasive pressure
First real-time pressure value of the first pressure value generation that detector 121 gathers, and beat cycles, are made with the blood pressure of priming line
For main control parameter, and then change the rotating speed of the first centrifugal blood pump 127, produce the blood pressure of beat cycles change, arteria hepatica is supplied
Blood, realizes the pulsatile fashion of simulation human body artery, closer to hepatic arterial human body blood supply state, can keep arteria hepatica blood vessel
The dilatancy and elasticity of ductus arteriosus wall.
Second centrifugal blood pump subsystem 10 includes the second master controller 109, and electric with the second master controller 109 respectively
The second centrifugal blood pump 107 and the second invasive pressure detector 101 of road connection；Second master controller 109, generation second are initial
Motor speed instructs, and carries out initial blood supply to portal vein, the second invasive pressure detector 101 gathers pylic second blood pressure
Value, the second master controller choose some second pressure values in predetermined period, and constant type blood is carried out to each second pressure value
Data processing is pressed, obtains the second real-time pressure value in predetermined period, generates the second rotary speed instruction.Second centrifugal blood pump is according to
Two rotary speed instructions adjust rotating speed, and blood supply is carried out to portal vein.
Specifically, the liver machine perfusion control device in the present embodiment, simulates the Supply form of human vein, by door
The constant progress voltage stabilizing blood supply in the range of specific pressure value of blood pressure in venous perfusion pipeline.
Liver machine perfusion control device in the present embodiment, it is preferable that using centrifugal blood pump, overcome conventional art
Middle ECMO systems use the Supply form of roller pump, have higher erythrocytolysis infringement to blood, are unfavorable for liver and repair
Multiple technical problem, and then lift the control ability to blood pressure.Preferably, independent two groups of centrifugal blood pumps perfusion system is set
System, one group is used for hepatic arterial infusion, is produced with pulsation type Supply form close to human heart and passes through blood supply of the artery to liver
Environment.Another group is used for portal vein perfusion, and the blood supply close to the lasting voltage stabilizing of human vein is produced with constant type Supply form
Environment.The hardware configuration of two systems system can be identical, can there are blood to liver based on two groups of identical hardware configuration systems
The two of parameter differences perform different Supply forms into blood vessel, improve the utilization rate of device systems, further optimize tradition machinery
Single blood supply system in perfusion.The present invention improves the repair ability to Marginal donor liver, and in vitro liver is operated and preserved
Effect, further prevent from causing Reperfu- sion to damage in liver in perfusing course.
To further illustrate the liver machine perfusion control device in above-described embodiment 1, referring to Fig. 2 to Fig. 3, Fig. 2 is liver
Dirty machine perfusion control device embodiment 1 carries out arteria hepatica the waveform diagram of pulsation type blood pressure data processing；Fig. 3 is liver
Machine perfusion control device embodiment 1 carries out portal vein the waveform diagram of constant type blood pressure data processing；
Pulsation type blood pressure data processing mode is used in the present embodiment, since hepatic arterial infusion blood pressure is using pulsation type
Blood supply, therefore the instantaneous blood pressure in hepatic arterial infusion pipeline is changed according to beat cycles, measurement hepatic arterial infusion blood pressure needs
Multiple discrete instantaneous blood pressures of (the similar key player on a team's wave period of as shown in Figure 2 one) are measured in beat cycles, it is filtered
And average treatment, the average irrigation blood pressure in beat cycles is obtained, and then obtain the first real-time pressure value.In the present embodiment, by
Mode in portal vein using constant type blood supply, therefore the blood pressure in portal vein perfusion pipeline is stable, there is no week
Phase change, therefore gather the certain predetermined cycle in (waveform as shown in Figure 3 be steady straight line, gather fixed intervals average time be
Can) multiple discrete instantaneous blood pressures, be filtered processing, obtain portal vein perfusion blood pressure, obtain the second real-time pressure value.
Liver machine perfusion control device in this example, the liver gathered respectively to the first invasive pressure detector 121 move
Arteries and veins priming line pressure value, using pulsation type blood pressure data processing mode, the door gathered to the second invasive pressure detector 101 is quiet
Arteries and veins priming line pressure value, using constant type blood pressure data processing mode, and then obtains the corresponding real-time pressure value of priming line.
Further, by the acquisition of real-time pressure value, the accurate speed governing to centrifugal blood pump rotating speed is improved, is simulated closer to true
Human heart is further lifted liver machinery in the embodiment of the present invention and is filled by the blood supply environment of arteria hepatica and portal vein to liver
Note control ability of the control device to priming line blood pressure.
With reference to Fig. 1, Fig. 4 is participated in, Fig. 4 is the blood flow parameter auxiliary monitoring of liver machine perfusion control device embodiment 1
Flow diagram, as shown in a in Fig. 4.The first blood flow amount detector 125 collection in first centrifugal blood pump subsystem 12 flows into
The blood flow of liver obtains the first real-time blood flow, and the first master controller 129 obtains the first goal-selling blood flow and first in fact
When blood flow；First master controller 129 is more than the first goal-selling blood flow in the numerical value for detecting the first real-time blood flow
During numerical value, send and stop blood supply early warning.As shown in b in Fig. 3, the second blood flow detection in the second centrifugal blood supply subsystem 10
105 course of work of device and realize that effect is identical with the first centrifugal blood pump subsystem, details are not described herein.
Liver machine perfusion control device in the present embodiment is using invasive pressure detector to the blood supply in priming line
Blood pressure is acquired and handles, and using the blood pressure in priming line as main control parameter, is realized by centrifugal blood pump to arteria hepatica
Priming line is regularly beaten, and then carries out pulsation type blood supply, and specific blood pressure model is maintained to portal vein perfusion pipeline blood pressure
Enclose and carry out constant type blood supply.Using blood flow amount detector, the real-time pressure value in priming line is gathered, is supervised by auxiliary of blood flow
Parameter is controlled, real time monitoring pours into the blood flow in liver, and the blood volume entered to prevent fluid stopping is exceeded.Liver machine perfusion in the present embodiment
Control device is using blood pressure as main control parameter, using blood flow as auxiliary monitoring parameter, is supplied with simulating the real heart of human body
Hemal ring border, reaches and blood supply is carried out under conditions of regulation blood pressure.ECMO systems in conventional art are overcome with constant blood flow to make
For main control parameter, blood supply is carried out with constant flow rate, when constant blood pressure is as auxiliary monitoring parameter, liver goes out in filling process
Existing oedema, and because causing the technology that perfusion blood pressure is excessive, causes liver vessel to rupture occur using constant flow rate as main contral parameter
Problem.
With reference to Fig. 1, referring to Fig. 5 to Fig. 6, Fig. 5 is the first centrifugal blood pump of liver machine perfusion control method embodiment 1
Subsystem pressure is the idiographic flow schematic diagram of main contral parameter；Fig. 6 be liver machine perfusion control method embodiment 1 second from
Core type blood pump subsystem pressure is the idiographic flow schematic diagram of main contral parameter；Based on embodiment described above 1, the present embodiment into
One step illustrates the liver machine perfusion control system of the present invention.
As shown in Figure 1, the liver machine perfusion control device in the present embodiment, it is preferable that two groups of independence can be included
Centrifugal blood pump subsystem, connects arteria hepatica respectively, to arteria hepatica carry out pulsation type blood supply, connect portal vein, to portal vein into
Row constant type blood supply.Preferably, two groups of centrifugal blood pump system hardware configurations can be identical, at its Supply form and blood pressure data
Reason mode is different.
Further, centrifugal blood pump system of the present invention includes invasive pressure detector, the blood being connected with master controller
Liquid stream amount detector, centrifugal blood pump, air-foam detector.
Invasive pressure detector in the present embodiment, is mainly used for gathering the real-time pressure value in blood perfusion pipeline.Have
Pressure detector is created, includes sequentially connected invasive blood pressure sensor, blood pressure converting transmission line and data acquisition line, preferably
Invasive pressure sensor can be disposable invasive blood pressure sensor, and further, invasive blood pressure sensor includes being connected with each other
Ultrasonic flow sensor and data acquisition board.Invasive blood pressure sensor is responsible for gathering the analog quantity number of priming line blood pressure
According to blood pressure converting transmission line is responsible for analog data being transferred to data acquisition board, and data acquisition board is responsible for analog data
Be converted to digital signal amount and be transmitted to master controller, to obtain real-time pressure data.
Centrifugal blood pump in the present embodiment, including sequentially connected centrifugal blood pump circuit for controlling motor module, centrifugal blood pump
Motor and centrifugal blood pump pump head, centrifugal blood pump circuit for controlling motor module are used to receive the rotating speed that master controller issues and set to refer to
Order, is powered centrifugal blood pump motor and speed control, makes motor high-speed rotation.Centrifugal blood pump pump head butts up against centrifugation blood
Pump motor, drives the blood in pump head to rotate so as to drive blood in a level pressure under the driving of centrifugal blood pump motor high-speed rotation
Flowed under power, carry out liver blood supply.Air-foam detector mainly includes the bubble detecting sensor and signal transmssion line being connected with each other,
For detecting, with the presence or absence of bubble, simultaneously upload information to master controller, prevents that bubble is filled into liver blood during perfusion in priming line
Cause artery blood pressure is excessive to cause to rupture in pipe.
Master controller in the present embodiment, mainly receives including sequentially connected touch display screen, blood pressure and data on flows
Unit and the perfusion motor control unit based on invasive blood pressure.Touch display screen can be with display of blood pressure and data on flows receiving unit
The real-time blood pressure data of upper hair, can down be sent instructions by touch display screen and irrigate motor control unit to based on invasive blood pressure.
Motor control unit is irrigated based on invasive blood pressure, is mainly used for receiving the data of invasive pressure detector collection, and to the data
Handled by pulsation type blood pressure data processing mode and constant pressure type blood pressure data processing mode, it is quiet to obtain arteria hepatica and door
Arteries and veins irrigates real-time blood pressure；Real-time blood pressure and acquisition according to receiving to be reached by the liver perfusion that touch display screen is set
Target blood pressure, the final centrifugal blood pump rotating speed to be reached is generated using blood pressure as main control parameter and is issued to centrifugal blood pump electricity
The rotating speed of machine, driving and adjustment centrifugation motor；Real-time blood pressure information, blood flow information and bubble detection information are received, if any super
Then halt system blood supply is marked, and sends warning information.
Invasive pressure sensor is restarted or replaced to the liver machine perfusion control device of the present embodiment every time, need to be to system
The target blood pressure and target blood flow parameter set returns to zero.
Specifically, the hardware configuration of two systems system can be identical, can be right based on two groups of identical hardware configuration systems
There are the two of blood parameters difference to perform different Supply form into blood vessel for liver, improves the utilization rate of device systems, further
Optimize single blood supply system in tradition machinery perfusion.
As shown in figure 5, the first centrifugal blood pump subsystem of liver machine perfusion control device in the present embodiment, with
Blood pressure is controlled using blood pressure rotating ratio coarse adjustment as main control parameter and combines proportional-integral-differential PID in master controller and controlled
Fuzzy control method for trimming, wherein the PID control unit 503 in real time of unit 503 processed have beat cycles.Root advance first
Blood pump motor speed revolution value table, i.e. blood pressure rotating ratio coarse adjustment table are established according to the pressure value of normal human, when the first master controller 501
When first goal-selling pressure value is set, the corresponding close electricity of goal-selling pressure value is selected according to blood pressure rotating ratio coarse adjustment table
Machine rotating speed, and be issued to the first centrifugal blood pump motor 505 and system is tentatively controlled.Then, it is default according to the first of acquisition
Target blood pressure value and the first real-time pressure value are calculated by PID control unit 503, obtain being turned according to what beat cycles changed
Speed is simultaneously issued to the first centrifugal blood pump motor 505, carries out in real time to 505 adjustment of rotational speed of the first centrifugal blood pump motor, makes arteria hepatica
Priming line close to human body artery pulsatile fashion, close to the hepatic arterial Supply form of human body.
Specifically, pulsation type Supply form combination PID control, changes motor speed by beat cycles and reaches arteria hepatica
Priming line blood pressure when it is high when it is low, form the external blood supply state similar to heart blood supply, keep liver is arterial vascular to move
The dilatancy and elasticity of blood vessel wall.
As shown in fig. 6, the second centrifugal blood pump subsystem of the liver machine perfusion control device in the present embodiment, with blood
Pressure is as main control parameter control principle with basically identical shown in Fig. 5, then this repeats no more.Difference is the PID control
Unit 603 does not possess beat cycles, and the second default pressure value and the second real-time pressure value of the second master controller 601 passes through
PID control unit 603 calculates, and the constant rotational speed not changed with beat cycles is obtained, by the 605 rotating speed control of the second centrifugal blood pump motor
System is in the range of specific rotation speeds so that portal vein perfusion pipeline continues voltage stabilizing blood supply.
Specifically, portal vein combination PID control unit 603 controls motor to obtain stabilized (steady-state) speed, maintains portal vein perfusion
The constant blood pressure blood supply of pipeline, close to the Supply form of portal vein in human body.
The liver machine perfusion control device of the present embodiment, using double perfusion control modes, respectively to the arteria hepatica of liver
Handled using pulsation type blood pressure data and pulsation type Supply form, portal vein use the processing of constant type blood pressure data and constant type
Supply form.Pulsation type Supply form combination beat cycles PID control, reaches liver by beat cycles change motor speed and moves
Arteries and veins priming line blood pressure when it is high when it is low, form the external blood supply state similar to heart blood supply, reach stable pulse frequency, contraction
Pressure, diastolic pressure and pulse pressure difference.Portal vein combines non-beat cycles PID control so that motor obtains stabilized (steady-state) speed, maintains door quiet
The constant blood pressure of arteries and veins priming line, close to the Supply form of portal vein in human body.The liver perfusion control of the embodiment of the present invention
System, improves machine perfusion to the control ability of in vitro liver blood pressure, to simulate the real heart blood supply environment of human body, reaches
Blood supply is carried out under the conditions of defined blood pressure, prevent liver transplant and filling process in, because occurring after oedema phenomenon because irrigating blood
Press through big, to cause liver vessel to rupture situation.Realize machine perfusion system to external liver reparation and preservation effect into
One-step optimization, there is provided close to the blood supply environment of real human body liver, reduce infringement of the in vitro liver in perfusing course, raising pair
The utilization rate of Marginal donor liver.
Referring to Fig. 7, Fig. 7 is the idiographic flow schematic diagram of liver machine perfusion control method embodiment 1.
As shown in fig. 7, the liver machine perfusion control method of this example is using pressure as main control parameter, including following step
Suddenly：
Step S710：First master controller is according to the first goal-selling pressure value, and the first centrifugal blood pump of driving is to arteria hepatica
Carry out initial blood supply；
Specifically, which initializes the first centrifugal blood pump subsystem, by hepatic arterial initial blood supply, making
System enters normal blood supply state.
Step S720：First master controller choose the first invasive pressure detector collection, in default beat cycles
Some first pressure values, pulsation type blood pressure data processing is carried out to each first pressure value, obtains the in default beat cycles
One real-time pressure value；
Specifically, since hepatic arterial infusion blood pressure is using pulsation type blood supply, in hepatic arterial infusion pipeline
Instantaneous blood pressure is changed according to beat cycles.By gathering some first pressure values in default beat cycles, and then obtain
Real-time pressure value in beat cycles, is conducive to the control to irrigating blood pressure.
Step S730：First master controller is according to the first goal-selling pressure value, the first real-time pressure value and default beating
In the cycle, driving the first centrifugal blood pump adjustment rotating speed, blood supply is carried out to arteria hepatica；
Specifically, by combining the first goal-selling pressure value, the first real-time pressure value and the control of default beat cycles
Algorithm processed, improves the accuracy to centrifugal blood pump adjustment of rotational speed.
Step S740：Second master controller is according to the second goal-selling pressure value, and the second centrifugal blood pump of driving is to portal vein
Carry out initial blood supply；
Specifically, which initializes the second centrifugal blood pump subsystem, by pylic initial blood supply, making
System enters normal blood supply state.
Step S750：Second main controller is chosen the second invasive pressure detector collection, some in predetermined period
Second pressure value, and constant type blood pressure data processing is carried out to each second pressure value, obtain the second real-time blood in predetermined period
Pressure value；
Specifically, since portal vein perfusion blood pressure is using constant type blood supply, in portal vein perfusion pipeline
Instantaneous blood pressure is continued for constant.By gathering some second pressure values in predetermined period, and then obtain same time interval
Interior real-time pressure value, is conducive to the control to irrigating blood pressure.
Step S760：Second master controller is according to the second goal-selling pressure value and the second real-time pressure value, driving second
Centrifugal blood pump adjusts rotating speed, and blood supply is carried out to portal vein.
Specifically, by combining the control algolithm of the second goal-selling pressure value and the second real-time pressure value, raising pair
The accuracy of centrifugal blood pump adjustment of rotational speed.
Referring to Fig. 8, Fig. 8 is tool of the blood flow of liver machine perfusion control method embodiment 1 as auxiliary monitoring parameter
Body flow diagram, as shown in a in Fig. 8, drive the first centrifugal blood pump adjustment rotating speed, to arteria hepatica carry out blood supply the step of it
It is further comprising the steps of afterwards：
Step S810：First master controller drives the first centrifugal blood pump adjustment rotating speed, and blood supply is carried out to arteria hepatica；
Step S820：Whether the numerical value that the first master controller detects the first actual flow of blood amount is more than the first default mesh
The numerical value of blood flow is marked, is to enter step S830, otherwise enters step S840；
Step S830：First master controller, which is sent, stops blood supply early warning；
Step S840：Continue to irrigate blood supply, return to step S810.
As shown in b in Fig. 8, after the step of driving the second centrifugal blood pump adjustment rotating speed, blood supply is carried out to arteria hepatica also
Comprise the following steps：
Step S860：Second master controller drives the second centrifugal blood pump adjustment rotating speed, and blood supply is carried out to arteria hepatica；
Step S870：Whether the numerical value that the second master controller detects the second actual flow of blood amount is more than the second goal-selling blood flow
The numerical value of amount, is to enter step S880, otherwise enters step S890；
Step S880：Second master controller, which is sent, stops blood supply early warning；
Step S890：Continue to irrigate blood supply, return to step S860.
Specifically, it is real using blood flow as auxiliary monitoring parameter in the liver machine perfusion control method of the present embodiment
When monitoring pour into blood flow in liver, the blood volume entered to prevent fluid stopping is exceeded.
Liver machine perfusion control method in the embodiment of the present invention, uses by being used as master using the blood pressure in priming line
Control parameter, blood flow is as auxiliary monitoring parameter, while the priming line blood pressure data to collecting carries out pulsation type respectively
Blood pressure data processing and the processing of constant type blood pressure data.The liver machine perfusion control method of the present invention, overcomes based on tradition
In the ECMO systems of technology, use using constant blood flow as main control parameter, constant blood pressure is as auxiliary monitoring parameter blood supply
Method, because oedema situation occurs in liver in filling process, and using constant blood flow as main contral parameter during oedema
It is excessive to there is perfusion blood pressure, the technical problem for causing liver vessel to rupture.And then traditional machine perfusion method is made further
Optimization, there is provided close to the blood supply environment of real human body liver, lift the reparation to external liver and preservation effect, reduce Vitro hepatic
The dirty infringement in perfusing course, improves the utilization rate to Marginal donor liver.
Referring to Fig. 9, Fig. 9 is the idiographic flow of the blood pressure data processing method of liver machine perfusion control method embodiment 1
Schematic diagram；As shown in a in Fig. 9, pulsation type blood pressure data processing method in the present embodiment, including step：
Step S910：First master controller chooses some first pressure values in beat cycles；
Step S920：First master controller carries out some first pressure values processing of averaging, and generation first averagely fills
Blood pressure is noted, obtains the first real-time pressure value.
Specifically, since hepatic arterial infusion blood pressure is using pulsation type blood supply, in hepatic arterial infusion pipeline
Instantaneous blood pressure is changed according to beat cycles.By gathering some first pressure values in default beat cycles, carry out asking flat
Average value processing, obtains the average irrigation blood pressure in beat cycles, and then obtains the first real-time pressure value, and it is right in priming line to improve
The control ability of blood pressure.
As shown in b in Fig. 9, constant type blood pressure data processing method in the present embodiment, including step：
Step S930：Second master controller chooses some second pressure values in predetermined period；
Step S940：Second master controller carries out average value processing to some second pressure values, and generation second is average
Blood pressure is irrigated, obtains the second real-time pressure value.
Specifically, since portal vein is using the mode of constant type blood supply, the blood in portal vein perfusion pipeline
Pressure is stable, there is no mechanical periodicity, therefore gathers some second pressure values in the certain predetermined cycle and carries out average value processing,
And then the second real-time pressure value is obtained, improve the control ability to blood pressure.
Liver machine perfusion control method in the embodiment of the present invention, pulsation type blood pressure data processing is carried out to arteria hepatica,
Constant type blood pressure data processing is carried out to portal vein.And then the accurate control to centrifugal blood pump rotating speed is improved, lifted to blood pressure
Control ability, simulates and closer passes through the blood supply environment of arteria hepatica and portal vein to liver with real human body heart.
The concrete technical scheme of corresponding above-mentioned liver machine perfusion control device and each embodiment of method, while in order to solve
Tradition machinery perfusion is unfavorable for liver blood supply and easily causes that perfusion blood pressure is excessive, and the problem of causing angiorrhoxis, the present invention also carries
A kind of liver machine perfusion control device is supplied.As shown in Figure 10, Figure 10 is the knot of liver machine perfusion control device embodiment 1
Structure schematic diagram, including
First control unit 1010, for according to the first goal-selling pressure value, the first centrifugal blood pump of driving to be to arteria hepatica
Carry out initial blood supply；Some first pressure values that the first invasive pressure detector gathers, in default beat cycles are chosen,
Pulsation type blood pressure data processing is carried out to each first pressure value, obtains the first real-time pressure value in default beat cycles；According to
First goal-selling pressure value, the first real-time pressure value and default beat cycles, driving the first centrifugal blood pump root adjustment rotating speed are right
Arteria hepatica carries out blood supply；
Second control unit 1020, for according to the second goal-selling pressure value, the second centrifugal blood pump of driving to be to portal vein
Carry out initial blood supply；Some second pressure values that the second invasive pressure detector gathers, in predetermined period are chosen, and it is right
Each second pressure value carries out constant type blood pressure data processing, obtains the second real-time pressure value in predetermined period；It is pre- according to second
If target blood pressure value and the second real-time pressure value, driving the second centrifugal blood pump adjustment rotating speed, blood supply is carried out to portal vein.
In the liver machine perfusion control device of the embodiment of the present invention, the first control unit 1010 and the second control unit
1020 configuration frame can be identical, based on identical configuration frame, can to liver there are blood parameters difference two into blood
Pipe performs different Supply forms, improves the utilization rate of device systems.The liver machine perfusion control device of the embodiment of the present invention,
When overcoming in conventional art ECMO systems and carrying out hemoperfusion to liver using single blood supply unit, because of arteria hepatica and portal vein
Two have differences into blood vessel, cause reparation to liver and the bad technical problem of preservation effect.Further, the first control is passed through
1010 and second control unit 1020 of unit processed initializes blood supply, further, by obtaining real-time pressure value, to control from
Painstaking effort revolution speed, in real time adjustment carry out liver the blood supply blood pressure of priming line during perfusion so that perfusion blood pressure maintains specific
Blood pressure range in.Further, pulsation type and constant type Supply form is respectively adopted, simulates and is supplied close to the real heart of human body
Hemal ring border.Liver machine perfusion control device in the embodiment of the present invention, realizes and keeps ductus arteriosus wall in hepatic arterial infusion pipeline
Dilatancy and elasticity, while maintain constant blood supply blood pressure in portal vein perfusion pipeline.
Liver transplant is unique effective means of End-stage liver disease caused by treating a variety of causes, in the world many states
Family, due to organ shortage, case fatality rate persistently remains high before transplanting waits list and transplanting.Marginal donor organ (including old age
Donor and steatosis supply liver) transplanting excited wide spread interest again and by clinical practice.Although recent donor amount
It increased, but be adapted to the liver quantity of transplanting to be still limited by cold preservation and ischemia reperfusion injury.Machine perfusion (Machine
Perfusion, MP) it is a kind of new organ preservation, transporting mode, native blood vessel is connected to organ machinery after organ acquisition
Perfusion system, system is preserved in organ and the transhipment stage continues perfusate to perfusion isolated organ, while supplies isolated organ
Oxygen and nutriment etc..Compared to cold preserve (Static the cold storage, SCS) of traditional static, MP can be protected preferably
Isolated organ is deposited, or even saves the outer organ of standard.Following machine perfusion may otherwise be applied to organ and recover, or even make
Optimize organ to transport the carrier of medicine.Pass through room temperature machine perfusion technology (Normothermic machine
Perfusion, NMP) administering medicine carries out the degreasing processing of steatosis liver, immunological regulation is with inducing immune tolerance and gene
Treatment etc..Conveying interstital stem cell can also be targeted in a suitable manner by NMP at the same time to transplant etc..
Liver machine perfusion control device of the present invention, method and device, pass through the arteria hepatica according to liver and portal vein two
A difference into blood vessel, using the arteriopalmus mode of simulation human body, sets up two independent centrifugal blood pump blood supply systems, point
It is other that pulsation type perfusion blood supply is carried out to arteria hepatica, constant type perfusion blood supply is carried out to portal vein.Further, the present invention moves liver
Blood pressure in arteries and veins priming line obtains real-time pressure value using pulsation type blood pressure data processing mode, in portal vein perfusion pipeline
Blood pressure real-time pressure value is obtained using constant type blood pressure data processing mode.In combination with goal-selling pressure value, real-time blood
Pressure value and setting cycle, using the blood supply blood pressure in priming line as main control parameter, the motor speed life of adjustment centrifugal blood pump
Into corresponding blood supply blood pressure, and then the Supply form close with true heart beating blood supply is produced to arteria hepatica respectively, to portal vein
Produce the Supply form for stablizing blood supply in human body close to true portal vein.Further, the present invention is also with priming line
Blood flow flows into the blood flow of liver as auxiliary monitoring parameter, detection, and the blood volume of liver is entered to prevent fluid stopping and exceeded is caused to liver
Dirty infringement.ECMO systems are overcome in conventional art using constant blood flow as main control parameter, using constant blood pressure as auxiliary
When helping monitoring parameter blood supply, because there is oedema in liver in filling process, and using constant flow rate as main contral parameter in oedema process
The middle technical problem for occurring irrigating that blood pressure is excessive, causes liver vessel to rupture.
The liver machine perfusion control device of the present invention, method and device, realize the further excellent of machine perfusion system
Change, there is provided close to the blood supply environment of real human body liver, lift the reparation to external liver and preservation effect, reduce external liver
Infringement in perfusing course, improves the utilization rate to Marginal donor liver.
Each technical characteristic of embodiment described above can be combined arbitrarily, to make description succinct, not to above-mentioned reality
Apply all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, the scope that this specification is recorded all is considered to be.
Embodiment described above only expresses the several embodiments of the present invention, its description is more specific and detailed, but simultaneously
Cannot therefore it be construed as limiting the scope of the patent.It should be pointed out that come for those of ordinary skill in the art
Say, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the protection of the present invention
Scope.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.
Claims (10)
1. a kind of liver machine perfusion control device, it is characterised in that including connection arteria hepatica, pulsation type confession is carried out to arteria hepatica
The the first centrifugal blood pump subsystem and connection portal vein of blood, the second centrifugal blood pump that constant type blood supply is carried out to portal vein
System；
The first centrifugal blood pump subsystem include the first of the first master controller and connection first master controller from
Painstaking effort pump, the first invasive pressure detector；
First master controller generates the first initial motor rotary speed instruction according to the first goal-selling pressure value；Described first
Centrifugal blood pump carries out initial blood supply, the first invasive pressure according to the first initial motor rotary speed instruction to the arteria hepatica
Force detector gathers hepatic arterial first pressure value；If first master controller is chosen in default beat cycles
First pressure value is done, pulsation type blood pressure data processing is carried out to each first pressure value, obtains the default beating week
The first real-time pressure value in phase；First master controller is according to the first goal-selling pressure value, described first real-time
Pressure value and the default beat cycles, generate the first rotary speed instruction；First centrifugal blood pump refers to according to first rotating speed
Order adjustment rotating speed, blood supply is carried out to the arteria hepatica；Wherein, the default beat cycles are each for default human body artery tube wall
The time of expansion and contraction；
The second centrifugal blood pump subsystem includes the of the second master controller and connection second main controller circuit
Two centrifugal blood pumps, the second invasive pressure detector；
Second master controller generates the second initial motor rotary speed instruction according to the second goal-selling pressure value；Described second
Centrifugal blood pump carries out initial blood supply, the second invasive pressure according to the second initial motor rotary speed instruction to the portal vein
Force detector gathers pylic second pressure value；Second master controller chooses some institutes in predetermined period
The second pressure value is stated, constant type blood pressure data processing is carried out to each second pressure value, obtains the in the predetermined period
Two real-time pressure values；Second master controller according to the second goal-selling pressure value and the second real-time pressure value,
Generate the second rotary speed instruction；Second centrifugal blood pump according to second rotary speed instruction adjust rotating speed, to the portal vein into
Row blood supply.
2. liver machine perfusion control device according to claim 1, it is characterised in that
The first centrifugal blood pump subsystem further includes the first blood flow amount detector being connected with first master controller；Institute
State the second centrifugal blood pump subsystem and further include the second blood flow amount detector being connected with second master controller；
First master controller obtains the first goal-selling blood flow and the first reality of the first blood flow amount detector collection
When blood flow, and detecting the described first real-time blood flow numerical value be more than the first goal-selling blood flow numerical value
When, early warning is sent, and sent to first centrifugal blood pump and stop blood supply instruction；
Second master controller obtains the second goal-selling blood flow and the second reality of the second blood flow amount detector collection
When blood flow, and detecting the described second real-time blood flow numerical value be more than the second goal-selling blood flow numerical value
When, early warning is sent, and sent to second centrifugal blood pump and stop blood supply instruction.
3. liver machine perfusion control device according to claim 2, it is characterised in that
First centrifugal blood pump includes sequentially connected first centrifugal blood pump motor circuit control module, the first centrifugal blood pump electricity
Machine and the first centrifugal blood pump pump head；
First master controller sends rotary speed instruction, the first centrifugal blood pump circuit for controlling motor according to the beat cycles
Module receives the rotary speed instruction, drives the first centrifugal blood pump motor to rotate according to the rotary speed instruction；What is rotated is described
First centrifugal blood pump motor drives the first centrifugal blood pump pump head to drive blood to rotate, and generates with beat cycles change
Blood supply blood pressure, blood supply is carried out to the arteria hepatica.
4. the liver machine perfusion control device according to claims 1 to 3 any one, it is characterised in that
Second centrifugal blood pump includes sequentially connected second centrifugal blood pump motor circuit control module, the second centrifugal blood pump electricity
Machine and the first centrifugal blood pump pump head；
Second master controller sends rotary speed instruction, drives the second centrifugal blood pump motor to turn according to the rotary speed instruction
Dynamic, the second centrifugal blood pump motor of rotation drives the second centrifugal blood pump pump head to drive blood to rotate, and generates constant confession
Blood blood pressure, blood supply is carried out to the portal vein.
5. liver machine perfusion control device according to claim 4, it is characterised in that
The first centrifugal blood pump subsystem further includes the first bubble detector being connected with first main controller circuit；
The second centrifugal blood pump subsystem further includes the second air-foam detector being connected with second main controller circuit；
First bubble information in the first bubble detector collection priming line, and the first bubble information is transmitted to
First master controller；First master controller sends early warning when detecting the first bubble information, and to described
First centrifugal blood pump, which is sent, stops blood supply instruction；
The second bubble information in the second air-foam detector collection priming line, and second bubble information is transmitted to
Second master controller；Second master controller sends early warning when detecting second bubble information, and to described
Second centrifugal blood pump, which is sent, stops blood supply instruction.
A kind of 6. liver machine perfusion control of the liver machine perfusion control device based on described in claim 1 to 5 any one
Method processed, it is characterised in that including step：
First master controller carries out initial blood supply according to the first goal-selling pressure value, the first centrifugal blood pump of driving to arteria hepatica；
First master controller choose the first invasive pressure detector collection, in default beat cycles some first
Pressure value, carries out pulsation type blood pressure data processing to each first pressure value, obtains first in the default beat cycles
Real-time pressure value；
First master controller is fought according to the first goal-selling pressure value, the first real-time pressure value and described preset
In the dynamic cycle, drive the first centrifugal blood pump adjustment rotating speed, blood supply carried out to the arteria hepatica；The default beat cycles are pre-
If each expansion and contraction of human body artery tube wall time；
Second master controller carries out initial blood supply according to the second goal-selling pressure value, the second centrifugal blood pump of driving to portal vein；
Second main controller chooses some second blood pressures that the second invasive pressure detector gathers, in predetermined period
Value, and constant type blood pressure data processing is carried out to each second pressure value, obtain the second real-time blood in the predetermined period
Pressure value；
Second master controller is according to the second goal-selling pressure value and the second real-time pressure value, driving described the
Two centrifugal blood pumps adjust rotating speed, and blood supply is carried out to the portal vein.
7. liver machine perfusion control method according to claim 6, it is characterised in that driving the first centrifugation blood
Pump adjustment rotating speed, to further including step after the step of arteria hepatica progress blood supply：
First master controller obtains the first real-time blood of the first goal-selling blood flow and the collection of the first blood flow amount detector
Flow, and when the numerical value for detecting the described first real-time blood flow is more than the numerical value of the first goal-selling blood flow, control
Make first centrifugal blood pump and stop blood supply, and send early warning.
8. liver machine perfusion control method according to claim 6, it is characterised in that driving the second centrifugation blood
Pump adjustment rotating speed, after the step of arteria hepatica progress blood supply, further includes step：
Second master controller obtains the second real-time blood of the second goal-selling blood flow and the collection of the second blood flow amount detector
Flow, and when the numerical value for detecting the described second real-time blood flow is more than the numerical value of the second goal-selling blood flow, control
Make second centrifugal blood pump and stop blood supply, and send early warning.
9. the liver machine perfusion control method according to claim 6 to 8 any one, it is characterised in that
First master controller carries out pulsation type blood pressure data processing to each first pressure value, obtains the default beating
The step of the first real-time pressure value in cycle, includes：
First master controller chooses some first pressure values in beat cycles；
First master controller carries out each first pressure value processing of averaging, and generates the first average irrigation blood pressure,
Obtain the described first real-time pressure value；
Second master controller carries out constant type blood pressure data processing to each second pressure value, obtains the predetermined period
The step of interior second real-time pressure value, includes：
Second master controller chooses some second pressure values in predetermined period；
Second master controller carries out average value processing to each second pressure value, generates the second average irrigation blood pressure, obtains
To the described second real-time pressure value.
A kind of 10. liver machine perfusion control device, it is characterised in that including：
First control unit, for being carried out to arteria hepatica initial according to the first goal-selling pressure value, the first centrifugal blood pump of driving
Blood supply；Some first pressure values that the first invasive pressure detector gathers, in default beat cycles are chosen, to each described
First pressure value carries out pulsation type blood pressure data processing, obtains the first real-time pressure value in the default beat cycles；According to
The first goal-selling pressure value, the first real-time pressure value and the default beat cycles, driving first centrifugation
Blood pump root adjusts rotating speed, and blood supply is carried out to the arteria hepatica；The default beat cycles are each for default human body artery tube wall
The time of expansion and contraction；
Second control unit, for being carried out to portal vein initial according to the second goal-selling pressure value, the second centrifugal blood pump of driving
Blood supply；Choose the second invasive pressure detector collection, some second pressure values in predetermined period, and to each described the
Two pressure values carry out constant type blood pressure data processing, obtain the second real-time pressure value in the predetermined period；According to described
Two goal-selling pressure values and the second real-time pressure value, drive the second centrifugal blood pump adjustment rotating speed, quiet to the door
Arteries and veins carries out blood supply.
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| CN110583621A (en) * | 2019-08-26 | 2019-12-20 | 无锡市人民医院 | In-vitro lung mechanical perfusion control system, method and device |
| CN113412834B (en) | 2021-08-25 | 2021-11-09 | 中山大学附属第一医院 | Multi-organ repairing and transferring device without interrupting blood flow |
| CN116235846B (en) * | 2023-02-27 | 2024-01-30 | 中国科学院苏州生物医学工程技术研究所 | Organ perfusion control method, system and device |
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Inventor after: Huo Feng Inventor after: Guan Yefeng Inventor after: Lin Yanzhi Inventor after: He Lei Inventor after: Xu Xiaoshan Inventor after: Zhang Lin Inventor after: Gao Yingqi Inventor after: Liu Huamin Inventor after: Lu Yan Inventor after: Feng Wenjie Inventor after: Liang Mingju Inventor after: Tan Xiaoyu Inventor after: Zhou Weijin Inventor after: Wang Shaoping Inventor after: Li Jiayu Inventor after: Sheng Hengwei Inventor after: Ren Xiaolong Inventor after: Zheng Yujian Inventor before: Liang Mingju Inventor before: Zhou Weijin |
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Effective date of registration: 20180323 Address after: Guangzhou City, Guangdong province 510010 Liuhua Road No. 111 Applicant after: Guangzhou General Hospital Guangzhou Military Command Applicant after: GUANGDONG SHUNDE INDUSTRIAL DESIGN INSTITUTE (GUANGDONG SHUNDE INNOVATIVE DESIGN INSTITUTE) Address before: 528300 Guangdong City, Shunde Province, Beijiao Town, Guangdong industrial design city design Plaza, B2 District, the two floor of the three floor Applicant before: GUANGDONG SHUNDE INDUSTRIAL DESIGN INSTITUTE (GUANGDONG SHUNDE INNOVATIVE DESIGN INSTITUTE) |
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Application publication date: 20170901 Assignee: Guangdong Ding Watson Medical Equipment Co., Ltd. Assignor: GUANGDONG SHUNDE INDUSTRIAL DESIGN INSTITUTE (GUANGDONG SHUNDE INNOVATIVE DESIGN INSTITUTE) Contract record no.: 2018440000068 Denomination of invention: Liver machine perfusion control system, method and device Granted publication date: 20180515 License type: Common License Record date: 20180522 |
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Effective date of registration: 20181212 Address after: 528300 Design Square Phase II, B2 District, No. 1 Sanle Road, Beijiao Town, Shunde District, Foshan City, Guangdong Province Patentee after: GUANGDONG SHUNDE INDUSTRIAL DESIGN INSTITUTE (GUANGDONG SHUNDE INNOVATIVE DESIGN INSTITUTE) Address before: Guangzhou City, Guangdong province 510010 Liuhua Road No. 111 Co-patentee before: GUANGDONG SHUNDE INDUSTRIAL DESIGN INSTITUTE (GUANGDONG SHUNDE INNOVATIVE DESIGN INSTITUTE) Patentee before: Guangzhou General Hospital Guangzhou Military Command |
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Effective date of registration: 20200512 Address after: 528300 Room 801, 8th Floor, Research Institute Building, Phase II, Sanle Road North 1, Residential Committee, Beijiao Town, Shunde District, Foshan City, Guangdong Province Patentee after: GUANGDONG DINGWOSHENG MEDICAL INSTRUMENT Co.,Ltd. Address before: Beijiao Town, Shunde District of Guangdong city of Foshan province Sanle 528300 northbound, Guangdong Industrial Design City Plaza two B2 District three floor Patentee before: GUANGDONG SHUNDE INDUSTRIAL DESIGN INSTITUTE (GUANGDONG SHUNDE INNOVATIVE DESIGN INSTITUTE) |
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