CN102986649B - In vitro continuous filling device used for autologous liver transplantation - Google Patents
In vitro continuous filling device used for autologous liver transplantation Download PDFInfo
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- CN102986649B CN102986649B CN201210550808.8A CN201210550808A CN102986649B CN 102986649 B CN102986649 B CN 102986649B CN 201210550808 A CN201210550808 A CN 201210550808A CN 102986649 B CN102986649 B CN 102986649B
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Abstract
The invention relates to an in vitro continuous filling device used for autologous liver transplantation. The in vitro continuous filling device comprises a liver removing platform (1) used for storing and removing liver, a liquid storage tank (2) and a Y-shaped pipe (3), wherein one end of the Y-shaped pipe (3) comprises a hepatic artery filling pipe (4) and a portal vein filling pipe (5) which are arranged in the liver removing platform (1), and the other end of the Y-shaped pipe (3) is communicated with the liquid storage tank (2); and the Y-shaped pipe (3) is also provided with a constant flow pump (6). The in vitro continuous filling device provided by the invention has the advantages that continuous low temperature filling is carried out on a machine by utilizing the in vitro continuous filling device, basic nutrients required by low temperature metabolism of the liver can be provided, and wastes produced during metabolism of the liver also can be eliminated; and various required medicines can be added into filling solution at any time, adverse factors caused by a pure static low temperature filling method can be corrected, and function of a disabled liver can be obviously improved, so that storage time is prolonged.
Description
Technical field
The present invention relates to technical field of medical instruments, specifically a kind of in vitro continous pouring device for autologous transplantation of liver.
Background technology
Autologous liver transfer operation (Auto liver transplantation, ALT) technology is a kind of surgical technic that current surgery of liver is most advanced, degree-of-difficulty factor is maximum, it is in the time that liver generation conventional method is difficult to the occupying lesion of excision, liver is partly shifted out external in vitro or all, under hypothermia perfusion condition, excise occupancy focus, then finishing retains a kind of surgical technic that liver implants again.It is the combination of complicated hepatectomy technology, organ hypothermia Perfusion preservation technology, external veno venous bypass technology, liver transfer operation vascular anastomosis technology.Compared with corpse liver transfer operation, autologous after liver transplantation does not need immunosuppressant treatment, has reduced medical expense, and reduces the meeting of Malignant Tumor Recurrence transfer, has further improved quality of life of patients, has important society and economic benefit.The residual liver dysfunction of postoperative generation is all relevant to the reperfusion injury after static state low temperature perfusion in art with liver failure, also be the bottleneck of the universal development of this operation of restriction, how preventing and treating severe postoperative ischemical reperfusion injury has become the important topic of the current research of autologous liver transfer operation.
Traditional static state low temperature perfusion is the main method of pouring in current autologous transplantation of liver, but due to a series of reasons such as the excessive generation of oxygen radical in liver cell and Calcium overloads, can cause liver function recovery in vitro liver cold preservation-reperfusion process to postpone, even liver function acute failure.Have no at present in vitro continous pouring device in special autologous transplantation of liver even domestic.
Summary of the invention
The object of this invention is to provide a kind of in vitro continous pouring device for autologous transplantation of liver, this device is exclusively used in isolated liver perfusion and preserves, easy to use, simple in structure, can extend the holding time.
The present invention is for the in vitro continous pouring device of autologous transplantation of liver, comprise: for deposit and hepatectomize cut liver platform 1, fluid reservoir 2 and Y tube 3, described Y tube 3 one end comprise and are positioned at hepatic arterial infusion pipe 4 and the portal vein perfusion pipe 5 of cutting liver platform 1, and described Y tube 3 other ends and fluid reservoir 2 are connected; On described Y tube 3, be also provided with constant flow pump 6.
On described hepatic arterial infusion pipe 4, portal vein perfusion pipe 5, be respectively equipped with unidirectional fluid-delivery valve 7.
On described Y tube 3, be provided with pressure and resistance inductor 8, described pressure and resistance inductor are connected with the control chip being arranged in fluid reservoir 2.
On described fluid reservoir 2, be also provided with temperature inductor, described temperature inductor is connected with the control chip being arranged in fluid reservoir.
The present invention for the advantage of the in vitro continous pouring device of autologous transplantation of liver is: utilize apparatus of the present invention to carry out the perfusion of machine continuous low temperature, can supply with the liver required basic nutrition of metabolism at low temperatures, can remove again refuse that its metabolism produces, and can in perfusion liquid, add various required medicines at any time, can correct the undesirable element that simple static state low temperature perfusion is brought, can obviously improve the function of residual liver, thereby extend the holding time.
Brief description of the drawings
Fig. 1 is the structural representation for the in vitro continous pouring device of autologous transplantation of liver.
Wherein: 1 for cutting liver platform, and 2 is fluid reservoir, and 3 is Y tube, and 4 is hepatic arterial infusion pipe, and 5 is portal vein perfusion pipe, and 6 is constant flow pump, and 7 is unidirectional fluid-delivery valve, and 8 is pressure and resistance inductor.
Embodiment
Below in conjunction with accompanying drawing, the present invention is further described: as shown in Figure 1, a kind of in vitro continous pouring device for autologous transplantation of liver, comprise: for deposit and hepatectomize cut liver platform 1, fluid reservoir 2 and Y tube 3, described Y tube 3 one end comprise and are positioned at hepatic arterial infusion pipe 4 and the portal vein perfusion pipe 5 of cutting liver platform 1, and described Y tube 3 other ends and fluid reservoir 2 are connected; On described Y tube 3, be also provided with constant flow pump 6.Cut and in liver platform 1 and fluid reservoir 2, be perfused with low temperature Liver Allograft Preservation Solution (as HTK liquid).Be connected with coeliac trunk, portal vein respectively and poured into by constant flow pump 6 by arterial perfusion pipe 4, portal vein perfusion pipe 5, constant flow pump 6 continues voltage supply to fluid reservoir 2, ensures that the perfusion liquid in fluid reservoir 2 continues to flow.
On described Y tube 3, be provided with pressure and resistance inductor 8, described pressure and resistance inductor 8 are connected with the control chip being arranged in fluid reservoir, can be abnormal at injection pressure, resistance provides warning when abnormal, find in time the problem existing.
On described fluid reservoir 2, be provided with temperature inductor, described temperature inductor is connected with the control chip being arranged in fluid reservoir, can in the time that temperature exceedes 4 DEG C, provide warning, reaches optimal preservation effect.
As preferably, on described hepatic arterial infusion pipe 4, portal vein perfusion pipe 5, be respectively equipped with unidirectional fluid-delivery valve 7.Unidirectional fluid-delivery valve 7 can guarantee arteria hepatica and portal vein to carry out unidirectional perfusion, and the perfusion liquid of input enters inferior caval vein output from liver after liver.
Described control chip is conventional in prior art, can temperature sensor, pressure and resistance, and can be at the control chip that exceeds critical value alarm.
Claims (2)
1. the in vitro continous pouring device for autologous transplantation of liver, comprise for deposit and hepatectomize cut liver platform (1) with fluid reservoir (2), it is characterized in that: also comprise that Y tube (3), described Y tube (3) one end comprise be positioned at cut liver platform hepatic arterial infusion pipe (1) (4) with portal vein perfusion pipe (5), (2) the described Y tube (3) other end and fluid reservoir is connected; (3) described Y tube is gone up and is also provided with constant flow pump (6); (8) described Y tube is provided with pressure and resistance inductor on (3), described pressure and resistance inductor (8) be arranged on the control chip of fluid reservoir in (2) and be connected; (2) described fluid reservoir is gone up and is also provided with temperature inductor, and described temperature inductor is connected with the control chip being arranged in fluid reservoir.
2. the in vitro continous pouring device for autologous transplantation of liver as claimed in claim 1, is characterized in that: described hepatic arterial infusion pipe (4), (7) portal vein perfusion pipe be respectively equipped with unidirectional fluid-delivery valve on (5).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210550808.8A CN102986649B (en) | 2012-12-18 | 2012-12-18 | In vitro continuous filling device used for autologous liver transplantation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210550808.8A CN102986649B (en) | 2012-12-18 | 2012-12-18 | In vitro continuous filling device used for autologous liver transplantation |
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| Publication Number | Publication Date |
|---|---|
| CN102986649A CN102986649A (en) | 2013-03-27 |
| CN102986649B true CN102986649B (en) | 2014-07-16 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201210550808.8A Active CN102986649B (en) | 2012-12-18 | 2012-12-18 | In vitro continuous filling device used for autologous liver transplantation |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104430302B (en) * | 2014-12-04 | 2016-05-18 | 宋涂润 | For preserving the normal temperature filling system of human organ |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008100636A2 (en) * | 2007-02-17 | 2008-08-21 | President And Fellows Of Harvard College | Compositions and method for tissue preservation |
| WO2008108996A1 (en) * | 2007-03-01 | 2008-09-12 | Lifeline Scientific, Inc. | Perfusion regulation |
| CN102217589A (en) * | 2011-05-05 | 2011-10-19 | 浙江大学 | Perfusion preservation device for liver |
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2012
- 2012-12-18 CN CN201210550808.8A patent/CN102986649B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008100636A2 (en) * | 2007-02-17 | 2008-08-21 | President And Fellows Of Harvard College | Compositions and method for tissue preservation |
| WO2008108996A1 (en) * | 2007-03-01 | 2008-09-12 | Lifeline Scientific, Inc. | Perfusion regulation |
| CN102217589A (en) * | 2011-05-05 | 2011-10-19 | 浙江大学 | Perfusion preservation device for liver |
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| CN102986649A (en) | 2013-03-27 |
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