CN102217589A - Perfusion preservation device for liver - Google Patents
Perfusion preservation device for liver Download PDFInfo
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- CN102217589A CN102217589A CN2011101154357A CN201110115435A CN102217589A CN 102217589 A CN102217589 A CN 102217589A CN 2011101154357 A CN2011101154357 A CN 2011101154357A CN 201110115435 A CN201110115435 A CN 201110115435A CN 102217589 A CN102217589 A CN 102217589A
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- water bath
- woven hose
- liver
- portal vein
- save set
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Abstract
The invention relates to a, especially a perfusion preservation device for liver. The perfusion preservation device for liver includes a water-bath case perfused with a preserving liquid. The device is characterized in that the inside of the water-bath case is provided with a bile duct perfusion tube connected to a bile duct, a hepatic artery perfusion tube in connection with a hepatic artery and a portal vein perfusion tube connected to a portal vein. The ends of the bile duct perfusion tube, the hepatic artery perfusion tube and the portal vein perfusion tube are all connected to a liquid storage pot through a pipeline. And the other end of the liquid storage pot is in connection with a pressure adjustable hydraulic pump that is connected to the water-bath case by a pipeline directly. Earmarked for liver perfusion preservation, the device of the invention is characterized by simple structure, convenient use, long storage and the like.
Description
Technical field
The present invention relates to a kind ofly, especially relate to a kind of liver perfusion save set.
Background technology
As everyone knows, according to World Health Organization's report, it is hepatitis B hepatitis viruse carrier that the present whole world has 3.5 hundred million people approximately, has every year 4500 ten thousand people to die from cirrhosis approximately, and 6,000 ten thousand people die from primary carcinoma of liver.China is the most serious hepatitis B infected in the world country, and it is the hepatitis carrier that 1.4 hundred million people are arranged approximately, accounts for 1/3rd of the world.Wherein 3,000 ten thousand is chronic hepatitis, cirrhosis, primary carcinoma of liver, die from every year chronic liver disease just up to 300,000 people.Zhejiang Province all is the big province of hepatopathy all the time, and average per 10 philtrums just have a hepatitis B virus infection person.And in vogue spirits culture and overwork promote that the hepatitis rapid progress is explosive liver failure or cirrhosis, liver cancer as the catalyzer.Make our province lose the large quantities of economic elite and the scientific elite, the whole province's labour's average level is greatly descended.Liver transplant has become the most effective methods of treatment of generally acknowledged treatment hepatopathy in whole latter stage, unfortunately Chinese cultural tradition, make the brain death method of China be difficult to pass and corpse is offered organs for transplant and is very difficult to obtain, the most receptors that the donor critical shortage makes is dead in wait.Therefore several at home big liver transplant of live body liver transplant in recent years center has obtained fast development.
Therefore, how to make exsomatize liver from take to clinical practice during this period of time in survival just become the problem of present research.In prior art, Liver Allograft Preservation has several different methods, but recent result of study shows that the ECP method has the better preserve effect, and the liver that exsomatizes can be survived 2-3 days.If make the Liver Allograft Preservation device for casting, can be and obtain humanized's liver at a distance and won the time according to this result of study.But at present, yet there are no the device that is exclusively used in the Liver Allograft Preservation perfusion like this.
Summary of the invention
The present invention mainly is at the above-mentioned technical problem of existing in prior technology, provides a kind of and is exclusively used in that liver perfusion is preserved, simple in structure, easy to use, liver perfusion save set that the resting period is long.
Above-mentioned technical problem of the present invention is mainly solved by following technical proposals: a kind of liver perfusion save set, comprise the water bath that is used to deposit liver, be perfused with preservation liquid in the water bath, it is characterized in that being respectively arranged with in the described water bath bile duct woven hose that is connected with bile duct, arteria hepatica woven hose that is connected with arteria hepatica and the portal vein woven hose that is connected with portal vein, described bile duct woven hose, the arteria hepatica woven hose, portal vein woven hose end all links to each other with fluid reservoir by pipeline, the described fluid reservoir other end is connected with the hydraulic pump of adjustable pressure, and described hydraulic pump directly is connected with water bath by pipeline.Link to each other with bile duct, arteria hepatica, portal vein on the liver respectively and pour into by bile duct woven hose, arteria hepatica woven hose, portal vein woven hose by hydraulic pump, hydraulic pump directly is connected with water bath by another root pipeline, water bath is continued voltage supply, guarantee that the preservation liquid recycle stream in the water bath is moving.
As preferably, be respectively arranged with unidirectional arteria hepatica fluid-delivery valve and unilateral gate venous transfusion valve on described arteria hepatica woven hose and the portal vein woven hose.For guaranteeing that arteria hepatica and portal vein are carried out unidirectional perfusion, on arteria hepatica woven hose and portal vein woven hose, be respectively arranged with unidirectional arteria hepatica fluid-delivery valve and unilateral gate venous transfusion valve, the preservation liquid of input is exported from the vena hepatica blood vessel of the other end after entering liver.
As preferably, described water bath links to each other with the oxygen pump by appendix.Can be to continue oxygen supply in the water bath by the oxygen pump, prolong the holding time.
As preferably, described water bath is provided with temperature controller, and described temperature controller links to each other with control chip in being arranged on water bath.Water bath is provided with temperature controller, and the temperature in the controlled water bath reaches optimal preservation effect about 15 °, and it is easy to use, practical.
As preferably, described water bath top offers and is used to pour into the loam cake of preserving liquid.Loam cake is turning opening structure, when needing filling to preserve liquid, loam cake can be opened the preservation liquid of can directly annotating from the top.
As preferably, described water bath bottom offers and is used to change the leakage fluid dram of preserving liquid.Leakage fluid dram uses the more convenient liquid discharge water bath cabinet of will preserving efficiently when being used for changing preservation liquid.
Therefore, the present invention has characteristics such as the liver perfusion of being exclusively used in is preserved, simple in structure, easy to use, resting period length, perfusion effect ideal.
Description of drawings
Accompanying drawing 1 is a kind of structural representation of the present invention.
Embodiment
Below by embodiment, and in conjunction with the accompanying drawings, technical scheme of the present invention is described in further detail.
Embodiment 1:
Shown in Figure of description 1, a kind of liver perfusion save set, comprise the water bath 1 that is used to deposit liver 3, be perfused with in the water bath and preserve liquid 2, the portal vein woven hose 6 that is respectively arranged with the bile duct woven hose 4 that is connected with bile duct, the arteria hepatica woven hose 5 that is connected with arteria hepatica in the water bath and is connected with portal vein, bile duct woven hose, arteria hepatica woven hose, portal vein woven hose end all link to each other with fluid reservoir 7 by pipeline, the fluid reservoir other end is connected with the hydraulic pump 12 of adjustable pressure, and hydraulic pump directly is connected with water bath by pipeline.Be respectively arranged with unidirectional arteria hepatica fluid-delivery valve 8 and unilateral gate venous transfusion valve 9 on arteria hepatica woven hose and the portal vein woven hose.Water bath links to each other with oxygen pump 10 by appendix.Water bath is provided with temperature controller 11, and temperature controller links to each other with control chip in being arranged on water bath.The water bath top offers and is used to pour into the loam cake 13 of preserving liquid.The water bath bottom offers and is used to change the leakage fluid dram 14 of preserving liquid.
When using the present invention to preserve perfusion, open loam cake 13 earlier, inject preservation liquid 2 from the top, liver 3 is put into preservation liquid, link to each other with bile duct, arteria hepatica, portal vein on the liver respectively by bile duct woven hose, arteria hepatica woven hose, portal vein woven hose then and pour into by hydraulic pump, hydraulic pump directly is connected with water bath by another root pipeline, and water bath is continued voltage supply, guarantees that the preservation liquid recycle stream in the water bath is moving.By the temperature controller that is provided with on the water bath, the temperature in the control water bath reaches optimal preservation effect at 15 °.By the oxygen pump is to continue oxygen supply in the water bath, prolongs the holding time.For guaranteeing that arteria hepatica and portal vein are carried out unidirectional perfusion, be respectively arranged with unidirectional arteria hepatica fluid-delivery valve and unilateral gate venous transfusion valve on arteria hepatica woven hose and portal vein woven hose, the preservation liquid of input is exported from the vena hepatica blood vessel 15 of the other end after entering liver.
Should be understood that this embodiment only to be used to the present invention is described and be not used in and limit the scope of the invention.Should be understood that in addition those skilled in the art can make various changes or modifications the present invention after the content of having read the present invention's instruction, these equivalent form of values fall within the application's appended claims institute restricted portion equally.
Claims (6)
1. liver perfusion save set, comprise the water bath (1) that is used to deposit liver (3), be perfused with in the water bath and preserve liquid (2), it is characterized in that being respectively arranged with in the described water bath bile duct woven hose (4) that is connected with bile duct, arteria hepatica woven hose (5) that is connected with arteria hepatica and the portal vein woven hose (6) that is connected with portal vein, described bile duct woven hose, the arteria hepatica woven hose, portal vein woven hose end all links to each other with fluid reservoir (7) by pipeline, the described fluid reservoir other end is connected with the hydraulic pump (12) of adjustable pressure, and described hydraulic pump directly is connected with water bath by pipeline.
2. liver perfusion save set according to claim 1 is characterized in that being respectively arranged with on described arteria hepatica woven hose and the portal vein woven hose unidirectional arteria hepatica fluid-delivery valve (8) and unilateral gate venous transfusion valve (9).
3. liver perfusion save set according to claim 1 and 2 is characterized in that described water bath links to each other with oxygen pump (10) by appendix.
4. liver perfusion save set according to claim 1 and 2 is characterized in that described water bath is provided with temperature controller (11), and described temperature controller links to each other with control chip in being arranged on water bath.
5. liver perfusion save set according to claim 1 and 2 is characterized in that described water bath top offers the loam cake (13) that is used to pour into preservation liquid.
6. liver perfusion save set according to claim 1 and 2 is characterized in that described water bath bottom offers the leakage fluid dram (14) that is used to change preservation liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101154357A CN102217589A (en) | 2011-05-05 | 2011-05-05 | Perfusion preservation device for liver |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101154357A CN102217589A (en) | 2011-05-05 | 2011-05-05 | Perfusion preservation device for liver |
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| Publication Number | Publication Date |
|---|---|
| CN102217589A true CN102217589A (en) | 2011-10-19 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN2011101154357A Pending CN102217589A (en) | 2011-05-05 | 2011-05-05 | Perfusion preservation device for liver |
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| CN (1) | CN102217589A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102986649A (en) * | 2012-12-18 | 2013-03-27 | 武汉大学 | In vitro continuous filling device used for autologous liver transplantation |
| CN103536989A (en) * | 2013-10-30 | 2014-01-29 | 安徽英特电子有限公司 | Water temperature control structure of water bath |
| CN106983088A (en) * | 2017-04-10 | 2017-07-28 | 青岛大学 | Suitable for the toxic removing animal's liver food and its processing method of infant |
| CN109769797A (en) * | 2017-11-13 | 2019-05-21 | 合肥华琪生物工程有限公司 | A kind of organ preservative fluid |
| CN113142192A (en) * | 2021-05-19 | 2021-07-23 | 北京盖兰德生物科技有限公司 | In-vitro liver perfusion activity maintaining device and using method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1543785A (en) * | 2003-11-20 | 2004-11-10 | 鞠烽炽 | Portable preserving device for liver external perfusing |
-
2011
- 2011-05-05 CN CN2011101154357A patent/CN102217589A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1543785A (en) * | 2003-11-20 | 2004-11-10 | 鞠烽炽 | Portable preserving device for liver external perfusing |
Non-Patent Citations (1)
| Title |
|---|
| 鱼军: "离体肝脏灌注保存的实验研究", 《中国优秀硕士学位论文全文数据库医药卫生科技辑》 * |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102986649A (en) * | 2012-12-18 | 2013-03-27 | 武汉大学 | In vitro continuous filling device used for autologous liver transplantation |
| CN102986649B (en) * | 2012-12-18 | 2014-07-16 | 武汉大学 | In vitro continuous filling device used for autologous liver transplantation |
| CN103536989A (en) * | 2013-10-30 | 2014-01-29 | 安徽英特电子有限公司 | Water temperature control structure of water bath |
| CN106983088A (en) * | 2017-04-10 | 2017-07-28 | 青岛大学 | Suitable for the toxic removing animal's liver food and its processing method of infant |
| CN106983088B (en) * | 2017-04-10 | 2018-07-27 | 青岛大学 | Toxic removing animal's liver food and its processing method suitable for infant |
| JP2019517785A (en) * | 2017-04-10 | 2019-06-27 | 青島大学 | Detoxifying animal liver food suitable for infants and a method for treating the same |
| CN109769797A (en) * | 2017-11-13 | 2019-05-21 | 合肥华琪生物工程有限公司 | A kind of organ preservative fluid |
| CN113142192A (en) * | 2021-05-19 | 2021-07-23 | 北京盖兰德生物科技有限公司 | In-vitro liver perfusion activity maintaining device and using method thereof |
| CN113142192B (en) * | 2021-05-19 | 2024-05-17 | 北京盖兰德生物科技有限公司 | Isolated liver perfusion activity maintaining device and use method thereof |
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Application publication date: 20111019 |