CN104411682B - 用于制备立体选择性环氧酮化合物的方法 - Google Patents

用于制备立体选择性环氧酮化合物的方法 Download PDF

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Publication number
CN104411682B
CN104411682B CN201380033893.3A CN201380033893A CN104411682B CN 104411682 B CN104411682 B CN 104411682B CN 201380033893 A CN201380033893 A CN 201380033893A CN 104411682 B CN104411682 B CN 104411682B
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compound
group
minutes
solution
added
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CN201380033893.3A
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English (en)
Chinese (zh)
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CN104411682A (zh
Inventor
西野幸宏
涌井和也
村濑翔太
境芳郁
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Nissan Chemical Corp
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Nissan Chemical Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C07D301/02—Synthesis of the oxirane ring
    • C07D301/03—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds
    • C07D301/19—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds with organic hydroperoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
CN201380033893.3A 2012-06-29 2013-06-27 用于制备立体选择性环氧酮化合物的方法 Expired - Fee Related CN104411682B (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
JP2012-146821 2012-06-29
JP2012146821 2012-06-29
US201261735196P 2012-12-10 2012-12-10
US61/735,196 2012-12-10
JP2013026801 2013-02-14
JP2013-026801 2013-02-14
US201361789996P 2013-03-15 2013-03-15
US61/789,996 2013-03-15
PCT/JP2013/068308 WO2014003203A2 (en) 2012-06-29 2013-06-27 Method for producing stereoselective epoxyketone compound

Publications (2)

Publication Number Publication Date
CN104411682A CN104411682A (zh) 2015-03-11
CN104411682B true CN104411682B (zh) 2016-11-16

Family

ID=49783967

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380033893.3A Expired - Fee Related CN104411682B (zh) 2012-06-29 2013-06-27 用于制备立体选择性环氧酮化合物的方法

Country Status (6)

Country Link
US (1) US9187442B2 (enExample)
EP (1) EP2867202B1 (enExample)
JP (1) JP6176259B2 (enExample)
CN (1) CN104411682B (enExample)
IN (1) IN2014DN10758A (enExample)
WO (1) WO2014003203A2 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104230857A (zh) * 2014-08-19 2014-12-24 上海皓元生物医药科技有限公司 卡非佐米(Carfilzomib)的中间体化合物的制备方法及其中间体化合物
US10364269B2 (en) 2015-05-21 2019-07-30 Laurus Labs Limited Processes for the preparation of carfilzomib or pharmaceutically acceptable salts thereof
CN105017181B (zh) * 2015-07-02 2017-10-10 南京师范大学 卡非佐米关键中间体及其衍生物的制备方法
CN105622458A (zh) * 2015-12-22 2016-06-01 中国药科大学 (s)-4-氨基-2-甲基-5-苯基戊-1-烯-3-酮的制备方法
DK3478670T3 (da) 2016-06-29 2023-05-15 Kezar Life Sciences Krystallinske salte af peptidepoxyketon-immunproteasomhæmmer
JP7065044B2 (ja) 2016-06-29 2022-05-11 ケザール ライフ サイエンシズ ペプチドエポキシケトン免疫プロテアソーム阻害剤、およびその前駆体の調製プロセス
EP3330260A1 (en) * 2016-12-01 2018-06-06 Enantia, S.L. Process for the preparation of an intermediate for the synthesis of i.a. carfilzomib

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG185963A1 (en) * 2004-05-10 2012-12-28 Onyx Therapeutics Inc Compounds for enzyme inhibition
US20050256324A1 (en) 2004-05-10 2005-11-17 Proteolix, Inc. Synthesis of amino acid keto-epoxides
EP1756079A2 (en) * 2004-05-17 2007-02-28 Proteolix, Inc. Synthesis of amino acid keto-epoxides
EP1775296A4 (en) 2004-06-25 2009-06-03 Nissan Chemical Ind Ltd CATALYST FOR THE OXIDATION OF ALCOHOL AND METHOD FOR THEIR SYNTHESIS
EP2484688B1 (en) 2006-06-19 2016-06-08 Onyx Therapeutics, Inc. Peptide epoxyketones for proteasome inhibition
JP4803074B2 (ja) 2007-03-06 2011-10-26 日産化学工業株式会社 アルコール酸化触媒およびその合成方法
US8013189B2 (en) * 2007-09-21 2011-09-06 Basf Se Accelerated amide and ester reductions with amine boranes and additives
MX2010003732A (es) 2007-10-04 2010-08-09 Onyx Therapeutics Inc Inhibidores de peptido cetona epoxi de proteasa cristalina y la sintesis de ceto-epoxidos de aminoacido.
US7902376B2 (en) * 2008-01-23 2011-03-08 Merck Sharp & Dohme Corp. Process for preparing chiral dipeptidyl peptidase-IV inhibitor intermediates
WO2009145323A1 (ja) 2008-05-30 2009-12-03 日産化学工業株式会社 多環式化合物を用いるアルコールの酸化方法

Also Published As

Publication number Publication date
JP2015526384A (ja) 2015-09-10
US20150126755A1 (en) 2015-05-07
CN104411682A (zh) 2015-03-11
US9187442B2 (en) 2015-11-17
WO2014003203A2 (en) 2014-01-03
JP6176259B2 (ja) 2017-08-09
IN2014DN10758A (enExample) 2015-09-04
EP2867202B1 (en) 2017-08-09
WO2014003203A3 (en) 2014-03-20
EP2867202A2 (en) 2015-05-06

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Granted publication date: 20161116

Termination date: 20180627